Mus musculus

138 known processes

Sh2d1b1

SH2 domain protein 1B1

(Aliases: Sh2d1b,Eat2a,EAT-2,Eat2,EAT-2A)

Sh2d1b1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of natural killer cell activation GO:0032814 22 0.910
Mouse
natural killer cell activation GO:0030101 44 0.761
Mouse
organelle fusion GO:0048284 28 0.572
membrane fusion GO:0061025 38 0.428
immune effector process GO:0002252 321 0.398
vesicle fusion GO:0006906 16 0.380
regulation of vesicle fusion GO:0031338 6 0.275
natural killer cell inhibitory signaling pathway GO:0002769 2 0.251
regulation of vesicle mediated transport GO:0060627 139 0.214
leukocyte mediated cytotoxicity GO:0001909 62 0.189
vesicle organization GO:0016050 60 0.167
leukocyte activation involved in immune response GO:0002366 126 0.161
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.160
membrane organization GO:0061024 245 0.157
innate immune response GO:0045087 157 0.149
cell killing GO:0001906 67 0.129
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.128
regulation of cell activation GO:0050865 289 0.127
Mouse
regulation of defense response GO:0031347 233 0.121
cellular amine metabolic process GO:0044106 44 0.119
cytokine production GO:0001816 319 0.117
regulation of organelle organization GO:0033043 289 0.109
positive regulation of cell killing GO:0031343 33 0.102
regulation of leukocyte mediated immunity GO:0002703 104 0.101
leukocyte mediated immunity GO:0002443 174 0.099
positive regulation of defense response GO:0031349 124 0.089
cell activation involved in immune response GO:0002263 126 0.084
immune response regulating signaling pathway GO:0002764 125 0.077
regulation of reactive oxygen species metabolic process GO:2000377 40 0.076
t cell activation GO:0042110 289 0.074
g protein coupled receptor signaling pathway GO:0007186 243 0.073
regulation of innate immune response GO:0045088 91 0.072
negative regulation of intracellular signal transduction GO:1902532 167 0.072
cation homeostasis GO:0055080 212 0.070
defense response to bacterium GO:0042742 119 0.067
immune response inhibiting signal transduction GO:0002765 4 0.067
reactive oxygen species metabolic process GO:0072593 84 0.066
regulation of cytokine production GO:0001817 266 0.065
immune response activating signal transduction GO:0002757 116 0.065
cellular response to biotic stimulus GO:0071216 92 0.062
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.060
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.060
positive regulation of cytokine production GO:0001819 174 0.060
chemotaxis GO:0006935 247 0.059
amine metabolic process GO:0009308 45 0.059
leukocyte chemotaxis GO:0030595 69 0.058
regulation of cellular amine metabolic process GO:0033238 20 0.057
regulation of ion transport GO:0043269 215 0.055
regulation of cellular ketone metabolic process GO:0010565 66 0.054
blood circulation GO:0008015 195 0.054
regulation of lymphocyte activation GO:0051249 240 0.053
Mouse
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.052
natural killer cell mediated cytotoxicity GO:0042267 29 0.051
negative regulation of cellular protein metabolic process GO:0032269 247 0.051
negative regulation of phosphorylation GO:0042326 166 0.050
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.049
regulation of natural killer cell mediated immunity GO:0002715 19 0.049
defense response to other organism GO:0098542 197 0.047
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.047
positive regulation of immune effector process GO:0002699 107 0.047
reactive nitrogen species metabolic process GO:2001057 0 0.046
placenta development GO:0001890 140 0.046
myeloid cell differentiation GO:0030099 233 0.046
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.046
leukocyte migration GO:0050900 124 0.046
regulation of system process GO:0044057 200 0.046
reactive oxygen species biosynthetic process GO:1903409 8 0.045
cellular lipid metabolic process GO:0044255 323 0.045
cell chemotaxis GO:0060326 81 0.044
negative regulation of protein phosphorylation GO:0001933 126 0.043
regulation of phospholipase c activity GO:1900274 3 0.043
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
positive regulation of innate immune response GO:0045089 80 0.042
transmembrane transport GO:0055085 412 0.040
negative regulation of phosphate metabolic process GO:0045936 184 0.039
response to molecule of bacterial origin GO:0002237 143 0.039
cellular response to molecule of bacterial origin GO:0071219 83 0.039
apoptotic signaling pathway GO:0097190 306 0.037
metal ion homeostasis GO:0055065 189 0.037
negative regulation of protein metabolic process GO:0051248 282 0.036
cellular calcium ion homeostasis GO:0006874 119 0.036
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.036
inflammatory response GO:0006954 244 0.036
osteoclast differentiation GO:0030316 62 0.035
homeostasis of number of cells GO:0048872 210 0.035
response to molecule of fungal origin GO:0002238 4 0.035
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.035
regulation of erk1 and erk2 cascade GO:0070372 71 0.035
myeloid leukocyte mediated immunity GO:0002444 42 0.035
extrinsic apoptotic signaling pathway GO:0097191 126 0.034
calcium mediated signaling GO:0019722 46 0.034
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.033
cellular metal ion homeostasis GO:0006875 151 0.033
sequestering of calcium ion GO:0051208 18 0.033
signal transduction in absence of ligand GO:0038034 55 0.033
lymphocyte differentiation GO:0030098 242 0.033
branching morphogenesis of an epithelial tube GO:0048754 159 0.032
positive regulation of secretion by cell GO:1903532 114 0.031
carbohydrate metabolic process GO:0005975 230 0.031
cellular response to acid chemical GO:0071229 68 0.031
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.031
mapk cascade GO:0000165 281 0.031
macromolecule catabolic process GO:0009057 281 0.030
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
myeloid leukocyte differentiation GO:0002573 119 0.030
positive regulation of protein modification process GO:0031401 299 0.030
regulation of mapk cascade GO:0043408 248 0.030
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.029
purine containing compound metabolic process GO:0072521 311 0.029
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.029
male gamete generation GO:0048232 285 0.029
acute inflammatory response GO:0002526 41 0.028
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.028
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.028
positive regulation of response to wounding GO:1903036 66 0.028
multi multicellular organism process GO:0044706 109 0.027
antigen receptor mediated signaling pathway GO:0050851 64 0.027
regulation of mast cell activation GO:0033003 21 0.027
response to drug GO:0042493 75 0.027
peptidyl amino acid modification GO:0018193 336 0.026
tissue homeostasis GO:0001894 115 0.026
cellular response to lipid GO:0071396 145 0.026
b cell activation GO:0042113 161 0.026
positive regulation of cell development GO:0010720 237 0.026
regulation of cell migration GO:0030334 219 0.026
chromatin organization GO:0006325 206 0.026
oxidation reduction process GO:0055114 342 0.026
negative regulation of immune effector process GO:0002698 55 0.025
phagocytosis GO:0006909 66 0.025
natural killer cell mediated immunity GO:0002228 29 0.025
regulation of apoptotic signaling pathway GO:2001233 197 0.025
interferon gamma production GO:0032609 67 0.025
leukocyte proliferation GO:0070661 172 0.024
positive regulation of angiogenesis GO:0045766 46 0.024
divalent inorganic cation transport GO:0072511 178 0.024
pattern recognition receptor signaling pathway GO:0002221 47 0.024
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.024
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.024
response to lipopolysaccharide GO:0032496 128 0.024
cellular response to lipopolysaccharide GO:0071222 77 0.023
purine ribonucleotide metabolic process GO:0009150 290 0.023
circulatory system process GO:0003013 197 0.023
multicellular organismal homeostasis GO:0048871 164 0.023
sensory perception GO:0007600 245 0.023
germ cell development GO:0007281 185 0.023
positive regulation of cell activation GO:0050867 158 0.023
negative regulation of cellular amine metabolic process GO:0033239 1 0.023
tissue remodeling GO:0048771 102 0.023
regulation of calcium mediated signaling GO:0050848 19 0.022
sequestering of metal ion GO:0051238 19 0.022
morphogenesis of a branching structure GO:0001763 203 0.022
humoral immune response GO:0006959 57 0.022
Mouse
cellular ketone metabolic process GO:0042180 84 0.022
nitrogen compound transport GO:0071705 271 0.022
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.022
cytosolic calcium ion homeostasis GO:0051480 70 0.022
glycoprotein metabolic process GO:0009100 116 0.022
erk1 and erk2 cascade GO:0070371 77 0.022
positive regulation of phospholipase c activity GO:0010863 2 0.022
regulation of homeostatic process GO:0032844 182 0.022
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.021
regulation of intracellular transport GO:0032386 159 0.021
b cell differentiation GO:0030183 78 0.021
negative regulation of cell activation GO:0050866 111 0.021
regulation of secretion GO:0051046 274 0.021
positive regulation of tumor necrosis factor production GO:0032760 30 0.021
monocyte extravasation GO:0035696 2 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
response to acid chemical GO:0001101 111 0.020
muscle tissue development GO:0060537 308 0.020
ameboidal type cell migration GO:0001667 128 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
neutrophil mediated immunity GO:0002446 19 0.020
regulation of body fluid levels GO:0050878 162 0.020
regulation of cell killing GO:0031341 40 0.020
negative regulation of apoptotic signaling pathway GO:2001234 104 0.020
skeletal muscle organ development GO:0060538 163 0.020
anion transport GO:0006820 177 0.020
peptidyl tyrosine phosphorylation GO:0018108 143 0.020
urogenital system development GO:0001655 261 0.019
compound eye development GO:0048749 1 0.019
regulation of b cell activation GO:0050864 81 0.019
regulation of angiotensin metabolic process GO:0060177 4 0.019
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.019
neutrophil migration GO:1990266 37 0.019
ossification GO:0001503 216 0.019
fat cell differentiation GO:0045444 160 0.019
spermatogenesis GO:0007283 284 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
regulation of protein transport GO:0051223 163 0.019
vascular process in circulatory system GO:0003018 62 0.019
cellular chemical homeostasis GO:0055082 215 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.018
regulation of leukocyte differentiation GO:1902105 159 0.018
regulation of hydrolase activity GO:0051336 246 0.018
positive regulation of neuron differentiation GO:0045666 141 0.018
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
cellular response to molecule of fungal origin GO:0071226 2 0.018
ion transmembrane transport GO:0034220 361 0.018
innate immune response activating signal transduction GO:0002758 50 0.018
regulation of osteoclast differentiation GO:0045670 36 0.018
regulation of metal ion transport GO:0010959 106 0.018
forebrain development GO:0030900 302 0.018
regulation of peptidase activity GO:0052547 96 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.017
cytoplasmic transport GO:0016482 234 0.017
nucleoside metabolic process GO:0009116 246 0.017
cytokine mediated signaling pathway GO:0019221 115 0.017
positive regulation of chemotaxis GO:0050921 38 0.017
transmission of nerve impulse GO:0019226 76 0.017
axonogenesis GO:0007409 274 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.017
t cell receptor signaling pathway GO:0050852 46 0.017
regulation of tissue remodeling GO:0034103 38 0.017
regulation of vasculature development GO:1901342 88 0.017
positive regulation of phospholipase activity GO:0010518 3 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
positive regulation of acute inflammatory response GO:0002675 16 0.016
regulation of t cell activation GO:0050863 170 0.016
antigen processing and presentation GO:0019882 47 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
tumor necrosis factor production GO:0032640 50 0.016
myeloid leukocyte activation GO:0002274 83 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
regulation of cytokine secretion GO:0050707 61 0.016
divalent metal ion transport GO:0070838 172 0.016
camera type eye development GO:0043010 266 0.016
regulation of hormone levels GO:0010817 211 0.016
response to oxygen levels GO:0070482 62 0.016
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.016
regulation of blood pressure GO:0008217 93 0.016
regulation of t cell extravasation GO:2000407 3 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
detection of yeast GO:0001879 2 0.016
cell recognition GO:0008037 83 0.016
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.016
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.016
synaptic transmission GO:0007268 329 0.016
cellular response to dna damage stimulus GO:0006974 207 0.016
protein glycosylation GO:0006486 55 0.016
positive regulation of leukocyte differentiation GO:1902107 86 0.015
response to decreased oxygen levels GO:0036293 59 0.015
striated muscle tissue development GO:0014706 293 0.015
positive regulation of nervous system development GO:0051962 221 0.015
protein secretion GO:0009306 111 0.015
cell growth GO:0016049 130 0.015
positive regulation of inflammatory response GO:0050729 47 0.015
positive regulation of lymphocyte activation GO:0051251 140 0.015
regulation of epithelial cell proliferation GO:0050678 141 0.015
fatty acid metabolic process GO:0006631 121 0.015
positive regulation of mapk cascade GO:0043410 170 0.015
regulation of proteolysis GO:0030162 164 0.015
negative regulation of leukocyte mediated immunity GO:0002704 29 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
t helper 17 cell chemotaxis GO:0035705 1 0.015
regulation of ossification GO:0030278 112 0.015
protein catabolic process GO:0030163 221 0.015
regulation of secretion by cell GO:1903530 249 0.015
regulation of hematopoietic stem cell migration GO:2000471 1 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
ribonucleoside metabolic process GO:0009119 245 0.014
maintenance of location GO:0051235 89 0.014
macromolecule glycosylation GO:0043413 55 0.014
regulation of leukocyte apoptotic process GO:2000106 56 0.014
regulation of cell motility GO:2000145 236 0.014
second messenger mediated signaling GO:0019932 73 0.014
regulation of protein secretion GO:0050708 82 0.014
cellular response to external stimulus GO:0071496 88 0.014
eosinophil activation GO:0043307 1 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
b cell mediated immunity GO:0019724 71 0.014
ras protein signal transduction GO:0007265 77 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
lipid biosynthetic process GO:0008610 179 0.014
sphingolipid metabolic process GO:0006665 45 0.014
dna metabolic process GO:0006259 303 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.014
blood vessel morphogenesis GO:0048514 285 0.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
regulation of tube size GO:0035150 57 0.014
neutrophil chemotaxis GO:0030593 36 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
t cell differentiation GO:0030217 174 0.014
positive regulation of t cell extravasation GO:2000409 2 0.014
stem cell development GO:0048864 219 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.013
regulation of lipase activity GO:0060191 15 0.013
gland development GO:0048732 330 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
response to inorganic substance GO:0010035 96 0.013
regulation of transmembrane transport GO:0034762 128 0.013
purine ribonucleoside metabolic process GO:0046128 241 0.013
ear development GO:0043583 200 0.013
morphogenesis of an epithelial sheet GO:0002011 27 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
regulation of kinase activity GO:0043549 249 0.013
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.013
regulation of anatomical structure size GO:0090066 178 0.013
regulation of cellular response to oxidative stress GO:1900407 19 0.013
ribonucleotide metabolic process GO:0009259 291 0.013
nuclear division GO:0000280 158 0.013
microglia development GO:0014005 2 0.013
regulation of interferon gamma production GO:0032649 57 0.013
negative regulation of growth GO:0045926 99 0.013
positive regulation of cell motility GO:2000147 116 0.013
neuron apoptotic process GO:0051402 142 0.013
defense response to gram positive bacterium GO:0050830 50 0.013
cell junction organization GO:0034330 77 0.013
epithelial cell migration GO:0010631 63 0.013
wound healing GO:0042060 157 0.013
methylation GO:0032259 134 0.013
microglia differentiation GO:0014004 2 0.013
regulation of transferase activity GO:0051338 263 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
cellular extravasation GO:0045123 17 0.012
positive regulation of ion transport GO:0043270 65 0.012
calcium ion homeostasis GO:0055074 127 0.012
organic anion transport GO:0015711 137 0.012
cd4 positive alpha beta t cell activation GO:0035710 45 0.012
anatomical structure homeostasis GO:0060249 145 0.012
neuron migration GO:0001764 122 0.012
glycoprotein biosynthetic process GO:0009101 89 0.012
regulation of exocytosis GO:0017157 61 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
granulocyte migration GO:0097530 43 0.012
protein processing GO:0016485 163 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
regulation of calcium ion transport GO:0051924 69 0.012
nucleotide metabolic process GO:0009117 332 0.012
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.012
negative regulation of synapse assembly GO:0051964 3 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
platelet morphogenesis GO:0036344 13 0.012
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.012
detection of stimulus GO:0051606 84 0.012
disruption by host of symbiont cells GO:0051852 11 0.012
response to oxidative stress GO:0006979 123 0.012
positive regulation of lymphocyte proliferation GO:0050671 70 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
negative regulation of molecular function GO:0044092 258 0.012
tissue migration GO:0090130 68 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
organelle localization GO:0051640 179 0.012
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.012
multicellular organismal signaling GO:0035637 91 0.011
cellular response to oxidative stress GO:0034599 76 0.011
cellular nitrogen compound catabolic process GO:0044270 280 0.011
response to organonitrogen compound GO:0010243 246 0.011
activation of innate immune response GO:0002218 56 0.011
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.011
negative regulation of secretion GO:0051048 61 0.011
regulation of interleukin 10 secretion GO:2001179 4 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
regulation of neuron differentiation GO:0045664 281 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
muscle cell differentiation GO:0042692 261 0.011
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.011
regulation of lymphocyte mediated immunity GO:0002706 84 0.011
camp metabolic process GO:0046058 40 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
positive regulation of glutamate secretion GO:0014049 2 0.011
defense response to gram negative bacterium GO:0050829 28 0.011
myeloid leukocyte migration GO:0097529 57 0.011
regulation of chemokine production GO:0032642 30 0.011
response to nutrient levels GO:0031667 109 0.011
regulation of angiotensin levels in blood GO:0002002 4 0.011
regulation of phagocytosis GO:0050764 33 0.011
cellular homeostasis GO:0019725 240 0.011
positive regulation of t cell activation GO:0050870 101 0.011
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.011
multi organism behavior GO:0051705 62 0.011
organ regeneration GO:0031100 2 0.011
exocytosis GO:0006887 121 0.011
positive regulation of phagocytosis GO:0050766 26 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
positive regulation of immunological synapse formation GO:2000522 1 0.011
response to transforming growth factor beta GO:0071559 88 0.011
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.011
dephosphorylation GO:0016311 129 0.011
response to peptide hormone GO:0043434 127 0.010
b cell proliferation GO:0042100 53 0.010
regulation of action potential GO:0098900 4 0.010
regulation of systemic arterial blood pressure GO:0003073 61 0.010
regulation of b cell proliferation GO:0030888 39 0.010
regulated secretory pathway GO:0045055 32 0.010
keratinocyte migration GO:0051546 3 0.010
regulation of t cell costimulation GO:2000523 2 0.010
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.010
glycerolipid metabolic process GO:0046486 122 0.010
lymphocyte activation involved in immune response GO:0002285 93 0.010
positive regulation of cytokine biosynthetic process GO:0042108 40 0.010
epithelial cell proliferation GO:0050673 174 0.010
negative regulation of cell migration GO:0030336 59 0.010
bone mineralization GO:0030282 54 0.010
steroid metabolic process GO:0008202 119 0.010
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.010
regulation of cell cycle GO:0051726 281 0.010
chloride transport GO:0006821 32 0.010
positive regulation of cell death GO:0010942 224 0.010
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.010
dna repair GO:0006281 107 0.010

Sh2d1b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.075
musculoskeletal system disease DOID:17 0 0.075
connective tissue disease DOID:65 0 0.075
bone disease DOID:0080001 0 0.072
disease of metabolism DOID:0014667 0 0.022
nervous system disease DOID:863 0 0.020
central nervous system disease DOID:331 0 0.015
sensory system disease DOID:0050155 0 0.011
organ system cancer DOID:0050686 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
cancer DOID:162 0 0.011