Mus musculus

263 known processes

Shank3

SH3/ankyrin domain gene 3

(Aliases: Shank3b,AI841104)

Shank3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small gtpase mediated signal transduction GO:0007264 97 0.678
axonogenesis GO:0007409 274 0.605
neuron projection guidance GO:0097485 141 0.479
gtp metabolic process GO:0046039 144 0.373
organonitrogen compound catabolic process GO:1901565 264 0.347
chemotaxis GO:0006935 247 0.307
regulation of nucleoside metabolic process GO:0009118 130 0.299
long term synaptic potentiation GO:0060291 25 0.298
erythrocyte differentiation GO:0030218 88 0.271
regulation of synaptic plasticity GO:0048167 87 0.263
regulation of cellular amine metabolic process GO:0033238 20 0.257
regulation of ras gtpase activity GO:0032318 88 0.257
nucleoside triphosphate metabolic process GO:0009141 230 0.253
regulation of hydrolase activity GO:0051336 246 0.251
purine ribonucleotide metabolic process GO:0009150 290 0.228
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.226
regulation of cellular ketone metabolic process GO:0010565 66 0.214
purine nucleoside catabolic process GO:0006152 205 0.211
rho protein signal transduction GO:0007266 32 0.204
ion transmembrane transport GO:0034220 361 0.200
cell recognition GO:0008037 83 0.198
regionalization GO:0003002 337 0.196
homeostasis of number of cells GO:0048872 210 0.195
cellular response to organonitrogen compound GO:0071417 145 0.195
positive regulation of ras gtpase activity GO:0032320 65 0.192
cellular amine metabolic process GO:0044106 44 0.192
forebrain generation of neurons GO:0021872 63 0.191
negative regulation of neuron differentiation GO:0045665 101 0.190
purine containing compound catabolic process GO:0072523 213 0.188
ribonucleoside triphosphate catabolic process GO:0009203 199 0.188
positive regulation of neuron differentiation GO:0045666 141 0.188
locomotory behavior GO:0007626 195 0.187
ribonucleotide metabolic process GO:0009259 291 0.184
purine ribonucleoside metabolic process GO:0046128 241 0.181
sensory perception GO:0007600 245 0.177
purine ribonucleoside catabolic process GO:0046130 205 0.176
regulation of neuron projection development GO:0010975 169 0.175
cellular amino acid metabolic process GO:0006520 103 0.168
developmental growth involved in morphogenesis GO:0060560 138 0.167
negative regulation of immune system process GO:0002683 209 0.163
dendrite development GO:0016358 115 0.160
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.157
glycosyl compound catabolic process GO:1901658 206 0.154
regulation of gtp catabolic process GO:0033124 113 0.154
ras protein signal transduction GO:0007265 77 0.151
positive regulation of cell development GO:0010720 237 0.151
developmental maturation GO:0021700 193 0.150
amine metabolic process GO:0009308 45 0.146
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.146
myeloid cell homeostasis GO:0002262 114 0.143
aromatic compound catabolic process GO:0019439 286 0.142
regulation of cellular amino acid metabolic process GO:0006521 5 0.142
ribonucleoside metabolic process GO:0009119 245 0.140
regulation of neuron differentiation GO:0045664 281 0.140
organophosphate catabolic process GO:0046434 232 0.138
neuromuscular process GO:0050905 99 0.138
negative regulation of cell proliferation GO:0008285 296 0.136
cellular response to cytokine stimulus GO:0071345 189 0.131
purine nucleoside triphosphate catabolic process GO:0009146 203 0.130
nucleobase containing small molecule metabolic process GO:0055086 352 0.129
actin cytoskeleton organization GO:0030036 220 0.125
regulation of cell projection organization GO:0031344 206 0.121
regulation of membrane potential GO:0042391 192 0.120
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.118
regulation of neuron death GO:1901214 134 0.118
regulation of system process GO:0044057 200 0.115
rhythmic process GO:0048511 174 0.115
Worm
anatomical structure homeostasis GO:0060249 145 0.114
nucleotide catabolic process GO:0009166 217 0.114
neuron recognition GO:0008038 25 0.113
positive regulation of nervous system development GO:0051962 221 0.113
neuron migration GO:0001764 122 0.112
negative regulation of cellular protein metabolic process GO:0032269 247 0.111
regulation of cell activation GO:0050865 289 0.110
cardiac cell fate specification GO:0060912 2 0.108
nucleoside phosphate metabolic process GO:0006753 338 0.108
purine ribonucleotide catabolic process GO:0009154 208 0.108
axon guidance GO:0007411 141 0.108
ribonucleoside catabolic process GO:0042454 206 0.108
circulatory system process GO:0003013 197 0.107
positive regulation of gtpase activity GO:0043547 85 0.107
cellular ketone metabolic process GO:0042180 84 0.106
purine nucleoside metabolic process GO:0042278 241 0.105
purine containing compound metabolic process GO:0072521 311 0.104
g protein coupled receptor signaling pathway GO:0007186 243 0.101
myeloid cell differentiation GO:0030099 233 0.101
negative regulation of cell development GO:0010721 169 0.101
carbohydrate derivative catabolic process GO:1901136 231 0.101
nucleoside catabolic process GO:0009164 206 0.100
neuron apoptotic process GO:0051402 142 0.098
male gamete generation GO:0048232 285 0.097
positive regulation of cellular amine metabolic process GO:0033240 5 0.097
synaptic transmission GO:0007268 329 0.096
regulation of circadian rhythm GO:0042752 58 0.095
cell type specific apoptotic process GO:0097285 268 0.095
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.093
regulation of cellular catabolic process GO:0031329 242 0.093
rac protein signal transduction GO:0016601 13 0.093
regulation of organelle organization GO:0033043 289 0.092
negative regulation of dendrite development GO:2000171 9 0.090
regulation of cellular component size GO:0032535 121 0.090
response to organonitrogen compound GO:0010243 246 0.090
cell maturation GO:0048469 127 0.088
peripheral nervous system neuron axonogenesis GO:0048936 3 0.087
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.086
negative regulation of nervous system development GO:0051961 156 0.084
protein autophosphorylation GO:0046777 61 0.084
organic cyclic compound catabolic process GO:1901361 295 0.083
ventricular system development GO:0021591 27 0.082
regulation of epidermal cell differentiation GO:0045604 21 0.082
negative regulation of leukocyte differentiation GO:1902106 51 0.082
regulation of rho gtpase activity GO:0032319 58 0.082
peptidyl amino acid modification GO:0018193 336 0.081
purine nucleotide catabolic process GO:0006195 211 0.081
single organism cell adhesion GO:0098602 156 0.080
negative regulation of protein metabolic process GO:0051248 282 0.080
regulation of secretion GO:0051046 274 0.079
muscle system process GO:0003012 141 0.079
regulation of nucleotide catabolic process GO:0030811 122 0.078
positive regulation of gtp catabolic process GO:0033126 85 0.078
regulation of cell motility GO:2000145 236 0.077
olfactory learning GO:0008355 2 0.076
peptide transport GO:0015833 133 0.076
single organismal cell cell adhesion GO:0016337 131 0.075
microtubule based process GO:0007017 236 0.075
guanosine containing compound catabolic process GO:1901069 144 0.075
regulation of neurotransmitter levels GO:0001505 87 0.074
regulation of purine nucleotide catabolic process GO:0033121 122 0.074
neuromuscular process controlling balance GO:0050885 59 0.073
hypothalamus gonadotrophin releasing hormone neuron development GO:0021888 4 0.073
regulation of response to wounding GO:1903034 189 0.072
nucleoside triphosphate catabolic process GO:0009143 205 0.072
regulation of vasculogenesis GO:2001212 9 0.071
cardiocyte differentiation GO:0035051 87 0.071
dorsal ventral axon guidance GO:0033563 3 0.071
ureteric bud development GO:0001657 94 0.071
regulation of ras protein signal transduction GO:0046578 114 0.071
negative regulation of molecular function GO:0044092 258 0.070
synapse organization GO:0050808 125 0.069
transmembrane transport GO:0055085 412 0.068
negative regulation of cell migration GO:0030336 59 0.068
telencephalon development GO:0021537 186 0.067
regulation of cardiac cell fate specification GO:2000043 1 0.067
regulation of rho protein signal transduction GO:0035023 71 0.067
angiogenesis GO:0001525 201 0.066
positive regulation of rho gtpase activity GO:0032321 41 0.066
positive regulation of nucleoside metabolic process GO:0045979 91 0.066
neuron neuron synaptic transmission GO:0007270 69 0.066
establishment of vesicle localization GO:0051650 81 0.065
cellular nitrogen compound catabolic process GO:0044270 280 0.065
epithelial cell proliferation GO:0050673 174 0.064
cellular response to lipid GO:0071396 145 0.063
lateral inhibition GO:0046331 1 0.063
positive regulation of cell projection organization GO:0031346 95 0.061
positive regulation of organelle organization GO:0010638 128 0.061
ribonucleotide catabolic process GO:0009261 208 0.061
regulation of ion transport GO:0043269 215 0.061
phospholipid metabolic process GO:0006644 87 0.060
cellular response to amino acid stimulus GO:0071230 29 0.060
blood circulation GO:0008015 195 0.060
gtp catabolic process GO:0006184 143 0.060
cell fate commitment GO:0045165 210 0.060
protein processing GO:0016485 163 0.059
regulation of vasculature development GO:1901342 88 0.059
nucleoside phosphate catabolic process GO:1901292 222 0.058
positive regulation of hydrolase activity GO:0051345 148 0.058
guanosine containing compound metabolic process GO:1901068 144 0.058
central nervous system neuron differentiation GO:0021953 162 0.058
smooth muscle cell chemotaxis GO:0071670 2 0.058
long term memory GO:0007616 15 0.057
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.057
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.057
t cell activation GO:0042110 289 0.057
regulation of cell migration GO:0030334 219 0.057
heterocycle catabolic process GO:0046700 280 0.055
germ cell development GO:0007281 185 0.055
detection of stimulus GO:0051606 84 0.055
positive regulation of nucleotide catabolic process GO:0030813 88 0.055
digestive system development GO:0055123 200 0.054
fertilization GO:0009566 127 0.054
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.054
cell matrix adhesion GO:0007160 68 0.054
platelet activation GO:0030168 40 0.053
dephosphorylation GO:0016311 129 0.053
cell migration involved in endocardial cushion formation GO:0003273 3 0.053
negative regulation of cell projection organization GO:0031345 56 0.053
organelle assembly GO:0070925 177 0.053
mesonephric tubule development GO:0072164 94 0.052
negative regulation of myeloid cell differentiation GO:0045638 38 0.052
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.052
muscle cell proliferation GO:0033002 52 0.052
regulation of cell cycle GO:0051726 281 0.051
oocyte development GO:0048599 33 0.051
morphogenesis of a branching structure GO:0001763 203 0.051
positive regulation of neuron projection development GO:0010976 79 0.051
regulation of glutamate receptor signaling pathway GO:1900449 16 0.051
neurotransmitter transport GO:0006836 76 0.051
regulation of gliogenesis GO:0014013 50 0.051
ribose phosphate metabolic process GO:0019693 291 0.050
respiratory tube development GO:0030323 167 0.050
positive regulation of axon extension GO:0045773 20 0.050
embryonic organ morphogenesis GO:0048562 276 0.050
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.050
tissue migration GO:0090130 68 0.049
positive regulation of nucleotide metabolic process GO:0045981 114 0.049
cell adhesion GO:0007155 329 0.049
detection of external stimulus GO:0009581 61 0.048
sensory perception of mechanical stimulus GO:0050954 107 0.048
transmission of nerve impulse GO:0019226 76 0.048
negative regulation of lymphocyte activation GO:0051250 91 0.047
gliogenesis GO:0042063 141 0.047
av node cell to bundle of his cell communication GO:0086067 2 0.047
ribonucleoside triphosphate metabolic process GO:0009199 220 0.046
nucleoside metabolic process GO:0009116 246 0.046
cell growth GO:0016049 130 0.046
wound healing GO:0042060 157 0.046
nucleotide metabolic process GO:0009117 332 0.046
glycosyl compound metabolic process GO:1901657 246 0.046
neurotransmitter secretion GO:0007269 62 0.045
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.045
positive regulation of rac protein signal transduction GO:0035022 1 0.045
positive regulation of membrane potential GO:0045838 15 0.045
purine nucleotide metabolic process GO:0006163 302 0.045
cardiac cell development GO:0055006 41 0.045
second messenger mediated signaling GO:0019932 73 0.043
positive regulation of cellular catabolic process GO:0031331 148 0.043
glial cell differentiation GO:0010001 131 0.043
multicellular organismal homeostasis GO:0048871 164 0.043
regulation of neuron apoptotic process GO:0043523 122 0.042
cyclic purine nucleotide metabolic process GO:0052652 43 0.042
cellular response to growth factor stimulus GO:0071363 197 0.041
epithelial cell proliferation involved in prostatic bud elongation GO:0060517 1 0.041
metanephros development GO:0001656 79 0.040
anion transport GO:0006820 177 0.040
mesonephros development GO:0001823 97 0.040
establishment of endothelial blood brain barrier GO:0014045 3 0.039
multicellular organismal response to stress GO:0033555 62 0.039
negative regulation of cell activation GO:0050866 111 0.039
response to light stimulus GO:0009416 135 0.039
apoptotic signaling pathway GO:0097190 306 0.039
epithelial cell development GO:0002064 159 0.038
notch signaling pathway GO:0007219 71 0.038
hematopoietic progenitor cell differentiation GO:0002244 143 0.038
negative regulation of cellular component organization GO:0051129 194 0.038
regulation of kinase activity GO:0043549 249 0.038
cognition GO:0050890 149 0.038
inner cell mass cellular morphogenesis GO:0001828 1 0.038
positive regulation of insulin secretion GO:0032024 26 0.038
nitrogen compound transport GO:0071705 271 0.037
positive regulation of lipid kinase activity GO:0090218 11 0.037
regulation of insulin receptor signaling pathway GO:0046626 21 0.037
cellular lipid metabolic process GO:0044255 323 0.037
cell chemotaxis GO:0060326 81 0.037
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.036
skeletal muscle organ development GO:0060538 163 0.036
multicellular organismal signaling GO:0035637 91 0.036
negative regulation of neuron projection development GO:0010977 50 0.036
regulation of long term synaptic depression GO:1900452 3 0.036
layer formation in cerebral cortex GO:0021819 13 0.035
regulation of notch signaling pathway GO:0008593 35 0.035
cation transmembrane transport GO:0098655 266 0.035
spermatid differentiation GO:0048515 115 0.035
action potential GO:0001508 78 0.035
female gamete generation GO:0007292 74 0.035
protein maturation GO:0051604 176 0.035
endothelial cell migration GO:0043542 44 0.035
regulation of dendritic spine morphogenesis GO:0061001 17 0.035
regulation of intracellular transport GO:0032386 159 0.035
positive regulation of cytokine production GO:0001819 174 0.035
response to heat GO:0009408 27 0.034
regulation of leukocyte differentiation GO:1902105 159 0.034
positive regulation of mapk cascade GO:0043410 170 0.034
nuclear division GO:0000280 158 0.034
associative learning GO:0008306 61 0.034
Mouse
habituation GO:0046959 3 0.034
Mouse
cellular response to interleukin 4 GO:0071353 21 0.034
photoreceptor cell differentiation GO:0046530 52 0.033
retina development in camera type eye GO:0060041 119 0.033
production of molecular mediator of immune response GO:0002440 103 0.033
pro t cell differentiation GO:0002572 3 0.033
t cell differentiation GO:0030217 174 0.033
cation transport GO:0006812 399 0.033
lymphocyte differentiation GO:0030098 242 0.033
response to amino acid GO:0043200 37 0.033
regulation of cell cycle process GO:0010564 160 0.032
nucleotide biosynthetic process GO:0009165 78 0.032
extracellular matrix organization GO:0030198 147 0.032
exocytosis GO:0006887 121 0.032
regulation of purine nucleotide metabolic process GO:1900542 169 0.032
respiratory system development GO:0060541 190 0.032
oocyte differentiation GO:0009994 35 0.032
muscle contraction GO:0006936 101 0.032
positive regulation of cell motility GO:2000147 116 0.032
cell cell recognition GO:0009988 44 0.032
response to radiation GO:0009314 165 0.032
muscle tissue development GO:0060537 308 0.032
lamellipodium organization GO:0097581 29 0.031
motor neuron axon guidance GO:0008045 26 0.031
insulin receptor signaling pathway GO:0008286 49 0.031
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.031
compartment pattern specification GO:0007386 4 0.031
organ growth GO:0035265 117 0.031
regulation of t cell activation GO:0050863 170 0.031
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.031
dendritic spine development GO:0060996 30 0.031
regulation of neurotransmitter transport GO:0051588 35 0.030
positive regulation of cell cycle GO:0045787 92 0.030
positive regulation of podosome assembly GO:0071803 3 0.030
stem cell differentiation GO:0048863 268 0.030
positive regulation of glutamate secretion GO:0014049 2 0.030
stem cell proliferation GO:0072089 117 0.030
lung development GO:0030324 164 0.030
regulation of transferase activity GO:0051338 263 0.030
skeletal system development GO:0001501 356 0.030
peptidyl tyrosine phosphorylation GO:0018108 143 0.030
regulation of heart contraction GO:0008016 77 0.029
purine nucleoside triphosphate metabolic process GO:0009144 226 0.029
erythropoietin mediated signaling pathway GO:0038162 1 0.029
cell cell adhesion GO:0098609 41 0.029
regulation of neural precursor cell proliferation GO:2000177 70 0.029
inositol lipid mediated signaling GO:0048017 41 0.029
lymphocyte proliferation GO:0046651 164 0.029
morphogenesis of embryonic epithelium GO:0016331 159 0.029
regulation of receptor activity GO:0010469 41 0.029
response to oxidative stress GO:0006979 123 0.029
developmental cell growth GO:0048588 84 0.029
regulation of synaptic transmission glutamatergic GO:0051966 19 0.028
camera type eye development GO:0043010 266 0.028
development of primary sexual characteristics GO:0045137 143 0.028
cellular response to peptide hormone stimulus GO:0071375 92 0.028
inflammatory response GO:0006954 244 0.028
peptidyl serine phosphorylation GO:0018105 74 0.028
multi multicellular organism process GO:0044706 109 0.028
response to acid chemical GO:0001101 111 0.028
regulation of inflammatory response GO:0050727 147 0.028
membrane depolarization GO:0051899 64 0.028
positive regulation of vasculogenesis GO:2001214 7 0.028
response to drug GO:0042493 75 0.028
regulation of anatomical structure size GO:0090066 178 0.027
regulation of long term synaptic potentiation GO:1900271 4 0.027
actomyosin structure organization GO:0031032 56 0.027
peripheral nervous system axon regeneration GO:0014012 2 0.027
regulation of transmembrane transport GO:0034762 128 0.027
multicellular organism growth GO:0035264 161 0.027
regulation of protein kinase activity GO:0045859 232 0.027
circadian rhythm GO:0007623 114 0.027
regulation of canonical wnt signaling pathway GO:0060828 82 0.026
regulation of muscle system process GO:0090257 80 0.026
response to organic cyclic compound GO:0014070 198 0.026
renal system development GO:0072001 225 0.026
negative regulation of endothelial cell migration GO:0010596 4 0.026
leukocyte migration GO:0050900 124 0.026
metanephric mesenchymal cell migration GO:0035789 2 0.026
regulation of postsynaptic membrane potential GO:0060078 48 0.026
negative regulation of neuron projection regeneration GO:0070571 3 0.026
cellular response to organic cyclic compound GO:0071407 87 0.026
response to temperature stimulus GO:0009266 55 0.025
urogenital system development GO:0001655 261 0.025
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 20 0.025
ribonucleotide biosynthetic process GO:0009260 59 0.025
regulation of metanephric mesenchymal cell migration GO:2000589 2 0.025
cellular response to insulin stimulus GO:0032869 78 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
regulation of lipid kinase activity GO:0043550 14 0.025
positive regulation of smooth muscle cell migration GO:0014911 4 0.025
response to insulin GO:0032868 100 0.025
protein targeting to membrane GO:0006612 20 0.025
kidney development GO:0001822 213 0.025
cellular protein complex assembly GO:0043623 116 0.024
divalent inorganic cation transport GO:0072511 178 0.024
insulin secretion GO:0030073 89 0.024
nephron development GO:0072006 109 0.024
positive regulation of peptide hormone secretion GO:0090277 31 0.024
sensory organ morphogenesis GO:0090596 242 0.024
regulation of ovulation GO:0060278 3 0.024
mitochondrion organization GO:0007005 134 0.024
learning or memory GO:0007611 148 0.024
synaptic transmission gabaergic GO:0051932 19 0.024
ameboidal type cell migration GO:0001667 128 0.024
negative regulation of synapse assembly GO:0051964 3 0.024
tripeptide transport GO:0042939 1 0.024
endodermal cell fate determination GO:0007493 2 0.024
ascending aorta morphogenesis GO:0035910 3 0.024
regulation of axon extension GO:0030516 43 0.024
cellular response to peptide GO:1901653 92 0.024
adherens junction organization GO:0034332 28 0.024
microtubule cytoskeleton organization GO:0000226 157 0.024
blood vessel morphogenesis GO:0048514 285 0.024
cyclic nucleotide metabolic process GO:0009187 59 0.024
binding of sperm to zona pellucida GO:0007339 34 0.024
regulation of secretion by cell GO:1903530 249 0.024
negative regulation of t cell activation GO:0050868 65 0.023
actin filament organization GO:0007015 113 0.023
cerebral cortex tangential migration using cell axon interactions GO:0021824 3 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.023
leukocyte mediated immunity GO:0002443 174 0.023
chromatin organization GO:0006325 206 0.023
negative regulation of neuron apoptotic process GO:0043524 92 0.023
primitive erythrocyte differentiation GO:0060319 3 0.023
regulation of lymphocyte activation GO:0051249 240 0.023
cellular response to thyroid hormone stimulus GO:0097067 1 0.023
mitral valve morphogenesis GO:0003183 4 0.023
hormone secretion GO:0046879 128 0.023
intracellular protein transport GO:0006886 204 0.023
endothelial cell differentiation GO:0045446 41 0.023
regulation of binding GO:0051098 111 0.023
negative regulation of apoptotic signaling pathway GO:2001234 104 0.023
negative regulation of protein phosphorylation GO:0001933 126 0.023
axon ensheathment GO:0008366 76 0.023
mapk cascade GO:0000165 281 0.023
cytokine production GO:0001816 319 0.023
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 1 0.023
response to peptide GO:1901652 136 0.023
anion transmembrane transport GO:0098656 71 0.023
positive regulation of cell migration GO:0030335 109 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
positive regulation of cellular component biogenesis GO:0044089 94 0.022
embryonic epithelial tube formation GO:0001838 130 0.022
response to erythropoietin GO:0036017 1 0.022
negative regulation of neuron death GO:1901215 98 0.022
maintenance of location GO:0051235 89 0.022
epithelial cell migration GO:0010631 63 0.022
ventral spinal cord development GO:0021517 48 0.022
nucleoside phosphate biosynthetic process GO:1901293 79 0.022
regulation of water loss via skin GO:0033561 16 0.022
regulation of blood coagulation GO:0030193 28 0.022
leukocyte chemotaxis GO:0030595 69 0.022
negative regulation of kinase activity GO:0033673 81 0.022
cell cell junction organization GO:0045216 72 0.022
protein oligomerization GO:0051259 67 0.022
Rat
phosphatidylinositol metabolic process GO:0046488 45 0.021
heart contraction GO:0060047 93 0.021
regulation of synapse structural plasticity GO:0051823 4 0.021
regulation of ion transmembrane transporter activity GO:0032412 54 0.021
regulation of cellular response to growth factor stimulus GO:0090287 82 0.021
cardiac muscle cell contraction GO:0086003 7 0.021
calcium ion transport GO:0006816 159 0.021
adult behavior GO:0030534 135 0.021
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.021
midgut development GO:0007494 4 0.021
purine ribonucleotide biosynthetic process GO:0009152 59 0.021
regulation of map kinase activity GO:0043405 120 0.021
regulation of cell adhesion GO:0030155 154 0.021
calcium ion dependent exocytosis GO:0017156 35 0.021
positive regulation of protein phosphorylation GO:0001934 242 0.021
cellular response to hormone stimulus GO:0032870 150 0.021
cartilage development GO:0051216 140 0.021
response to growth factor GO:0070848 198 0.021
cellular response to biotic stimulus GO:0071216 92 0.021
regulation of angiogenesis GO:0045765 81 0.020
regulation of nucleotide metabolic process GO:0006140 169 0.020
cell migration involved in coronary angiogenesis GO:0060981 1 0.020
carbohydrate derivative biosynthetic process GO:1901137 183 0.020
platelet derived growth factor receptor beta signaling pathway GO:0035791 4 0.020
mating GO:0007618 27 0.020
heart growth GO:0060419 45 0.020
formation of organ boundary GO:0010160 1 0.020
forebrain development GO:0030900 302 0.020
metanephric glomerulus morphogenesis GO:0072275 3 0.020
positive regulation of protein modification process GO:0031401 299 0.020
myeloid leukocyte migration GO:0097529 57 0.020
regulation of myeloid leukocyte differentiation GO:0002761 58 0.020
atrial septum primum morphogenesis GO:0003289 3 0.020
peptide secretion GO:0002790 114 0.020
muscle cell differentiation GO:0042692 261 0.020
oocyte construction GO:0007308 2 0.020
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.020
cytokine production involved in immune response GO:0002367 34 0.020
motor neuron migration GO:0097475 4 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.020
cell migration involved in kidney development GO:0035787 3 0.020
neuroblast division in subventricular zone GO:0021849 2 0.020
cellular response to lipopolysaccharide GO:0071222 77 0.020
regulation of ion transmembrane transport GO:0034765 119 0.020
regulation of myeloid cell differentiation GO:0045637 96 0.020
forebrain neuron differentiation GO:0021879 52 0.020
homotypic cell cell adhesion GO:0034109 28 0.020
positive regulation of macrophage differentiation GO:0045651 5 0.019
actin filament based movement GO:0030048 23 0.019
regulation of vesicle mediated transport GO:0060627 139 0.019
regulation of cytoskeleton organization GO:0051493 122 0.019
compound eye development GO:0048749 1 0.019
fat cell differentiation GO:0045444 160 0.019
sequestering of calcium ion GO:0051208 18 0.019
neural precursor cell proliferation GO:0061351 121 0.019
muscle fiber development GO:0048747 76 0.019
central nervous system projection neuron axonogenesis GO:0021952 21 0.019
positive regulation of transferase activity GO:0051347 167 0.019
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.019
regulation of jak stat cascade GO:0046425 34 0.019
cardiac conduction GO:0061337 17 0.019

Shank3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.243
nervous system disease DOID:863 0 0.243
disease of anatomical entity DOID:7 0 0.243
brain disease DOID:936 0 0.059
neurodegenerative disease DOID:1289 0 0.030