Mus musculus

37 known processes

Sik3

SIK family kinase 3

(Aliases: Qsk,mKIAA0999,MGC90906,AI447252,AI846254,9030204A07Rik,5730525O22Rik,AI849445,MGC91236)

Sik3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
fat cell differentiation GO:0045444 160 0.256
epidermis development GO:0008544 187 0.233
action potential GO:0001508 78 0.219
epithelial tube morphogenesis GO:0060562 303 0.219
regulation of cellular ketone metabolic process GO:0010565 66 0.207
Mouse
regulation of lipid metabolic process GO:0019216 118 0.200
Mouse
cellular lipid metabolic process GO:0044255 323 0.190
Mouse
regulation of kinase activity GO:0043549 249 0.184
negative regulation of phosphorus metabolic process GO:0010563 184 0.182
regulation of transferase activity GO:0051338 263 0.181
digestive system development GO:0055123 200 0.181
developmental maturation GO:0021700 193 0.181
chemotaxis GO:0006935 247 0.173
regulation of apoptotic signaling pathway GO:2001233 197 0.163
regulation of protein kinase activity GO:0045859 232 0.162
cytokine production GO:0001816 319 0.151
negative regulation of molecular function GO:0044092 258 0.146
Mouse
oxidation reduction process GO:0055114 342 0.146
regulation of intracellular transport GO:0032386 159 0.146
organelle assembly GO:0070925 177 0.143
response to organonitrogen compound GO:0010243 246 0.138
Mouse
regulation of protein localization GO:0032880 231 0.136
ras protein signal transduction GO:0007265 77 0.134
regulation of protein serine threonine kinase activity GO:0071900 157 0.131
regulation of secretion by cell GO:1903530 249 0.131
regulation of cellular component biogenesis GO:0044087 181 0.130
connective tissue development GO:0061448 179 0.130
regulation of map kinase activity GO:0043405 120 0.127
negative regulation of protein phosphorylation GO:0001933 126 0.126
regulation of cellular amine metabolic process GO:0033238 20 0.120
monosaccharide metabolic process GO:0005996 106 0.118
Mouse
peptide transport GO:0015833 133 0.118
myeloid cell differentiation GO:0030099 233 0.118
response to insulin GO:0032868 100 0.113
Mouse
nitrogen compound transport GO:0071705 271 0.113
negative regulation of protein modification process GO:0031400 163 0.112
negative regulation of phosphorylation GO:0042326 166 0.112
cytokine mediated signaling pathway GO:0019221 115 0.104
monocarboxylic acid catabolic process GO:0072329 27 0.104
apoptotic signaling pathway GO:0097190 306 0.104
regulation of establishment of protein localization GO:0070201 181 0.103
mitochondrion organization GO:0007005 134 0.102
regulation of cellular amino acid metabolic process GO:0006521 5 0.102
cellular response to insulin stimulus GO:0032869 78 0.100
Mouse
mapk cascade GO:0000165 281 0.100
regulation of secretion GO:0051046 274 0.098
anion transport GO:0006820 177 0.098
cation transport GO:0006812 399 0.097
positive regulation of protein phosphorylation GO:0001934 242 0.096
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.095
positive regulation of cellular amine metabolic process GO:0033240 5 0.095
cellular amino acid metabolic process GO:0006520 103 0.093
regulation of body fluid levels GO:0050878 162 0.092
wound healing GO:0042060 157 0.092
digestive tract development GO:0048565 190 0.092
camera type eye development GO:0043010 266 0.091
cation homeostasis GO:0055080 212 0.091
response to oxidative stress GO:0006979 123 0.090
regulation of membrane potential GO:0042391 192 0.089
cellular response to organonitrogen compound GO:0071417 145 0.088
Mouse
hair follicle development GO:0001942 85 0.088
positive regulation of cell development GO:0010720 237 0.087
cellular response to cytokine stimulus GO:0071345 189 0.087
organic acid catabolic process GO:0016054 51 0.087
myeloid leukocyte differentiation GO:0002573 119 0.086
locomotory behavior GO:0007626 195 0.086
regulation of circadian rhythm GO:0042752 58 0.084
Mouse
regulation of cellular response to stress GO:0080135 159 0.084
hormone secretion GO:0046879 128 0.084
ameboidal type cell migration GO:0001667 128 0.084
response to peptide GO:1901652 136 0.082
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.080
single organism nuclear import GO:1902593 95 0.080
anatomical structure homeostasis GO:0060249 145 0.080
regulation of cellular catabolic process GO:0031329 242 0.080
dna metabolic process GO:0006259 303 0.079
regulation of protein import into nucleus GO:0042306 52 0.079
amine metabolic process GO:0009308 45 0.078
cellular ketone metabolic process GO:0042180 84 0.078
Mouse
regulation of feeding behavior GO:0060259 3 0.078
sensory organ morphogenesis GO:0090596 242 0.078
molting cycle GO:0042303 90 0.078
cell maturation GO:0048469 127 0.078
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.078
Worm
negative regulation of phosphate metabolic process GO:0045936 184 0.077
axon guidance GO:0007411 141 0.077
branching morphogenesis of an epithelial tube GO:0048754 159 0.076
negative regulation of protein metabolic process GO:0051248 282 0.076
epithelial cell development GO:0002064 159 0.075
negative regulation of apoptotic signaling pathway GO:2001234 104 0.075
male gamete generation GO:0048232 285 0.075
skeletal system development GO:0001501 356 0.074
monocarboxylic acid metabolic process GO:0032787 191 0.074
negative regulation of feeding behavior GO:2000252 1 0.073
skin development GO:0043588 220 0.073
regulation of organ morphogenesis GO:2000027 144 0.073
regulation of vacuole organization GO:0044088 4 0.072
regulation of protein targeting GO:1903533 61 0.072
negative regulation of intracellular signal transduction GO:1902532 167 0.071
homeostasis of number of cells GO:0048872 210 0.071
regulation of fat cell differentiation GO:0045598 81 0.071
protein heterotetramerization GO:0051290 4 0.070
peptidyl amino acid modification GO:0018193 336 0.070
establishment of protein localization to organelle GO:0072594 118 0.070
cytoplasmic transport GO:0016482 234 0.069
circadian rhythm GO:0007623 114 0.069
Mouse
glucose homeostasis GO:0042593 128 0.069
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.068
small gtpase mediated signal transduction GO:0007264 97 0.068
cellular amine metabolic process GO:0044106 44 0.068
regulation of cytokine production GO:0001817 266 0.068
hexose metabolic process GO:0019318 98 0.067
Mouse
glucose metabolic process GO:0006006 92 0.067
Mouse
cellular lipid catabolic process GO:0044242 52 0.067
ensheathment of neurons GO:0007272 76 0.066
response to testosterone GO:0033574 3 0.066
amide transport GO:0042886 138 0.066
intracellular protein transport GO:0006886 204 0.065
cellular response to inorganic substance GO:0071241 37 0.064
response to radiation GO:0009314 165 0.064
Mouse
protein targeting GO:0006605 143 0.064
regulation of ion transport GO:0043269 215 0.064
peptide secretion GO:0002790 114 0.064
positive regulation of programmed cell death GO:0043068 218 0.064
regulation of protein transport GO:0051223 163 0.064
positive regulation of transferase activity GO:0051347 167 0.064
cellular response to peptide GO:1901653 92 0.063
Mouse
positive regulation of cellular catabolic process GO:0031331 148 0.062
transmission of nerve impulse GO:0019226 76 0.061
spermatogenesis GO:0007283 284 0.061
fat soluble vitamin biosynthetic process GO:0042362 4 0.060
response to oxygen levels GO:0070482 62 0.060
asymmetric stem cell division GO:0098722 3 0.060
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.060
aromatic compound catabolic process GO:0019439 286 0.060
glucose import GO:0046323 32 0.060
neuron projection guidance GO:0097485 141 0.059
positive regulation of glycolytic process GO:0045821 4 0.059
germ cell development GO:0007281 185 0.058
regulation of peptide hormone secretion GO:0090276 75 0.058
regulation of anatomical structure size GO:0090066 178 0.058
regulation of nucleocytoplasmic transport GO:0046822 73 0.058
regulation of organelle organization GO:0033043 289 0.058
cellular response to hormone stimulus GO:0032870 150 0.058
Mouse
regulation of carbohydrate biosynthetic process GO:0043255 40 0.057
Mouse
purine containing compound metabolic process GO:0072521 311 0.057
multicellular organismal homeostasis GO:0048871 164 0.057
nuclear transport GO:0051169 139 0.056
response to peptide hormone GO:0043434 127 0.056
Mouse
brown fat cell differentiation GO:0050873 36 0.055
carbohydrate metabolic process GO:0005975 230 0.055
Mouse
response to reactive oxygen species GO:0000302 56 0.054
regulation of neuron differentiation GO:0045664 281 0.054
lipid catabolic process GO:0016042 69 0.054
divalent metal ion transport GO:0070838 172 0.054
regulation of cellular component size GO:0032535 121 0.054
negative regulation of transferase activity GO:0051348 85 0.054
positive regulation of cell death GO:0010942 224 0.053
divalent inorganic cation homeostasis GO:0072507 138 0.053
actin cytoskeleton organization GO:0030036 220 0.053
protein import GO:0017038 101 0.053
regulation of epithelial cell proliferation GO:0050678 141 0.053
multicellular organismal signaling GO:0035637 91 0.053
cell adhesion GO:0007155 329 0.052
calcium ion homeostasis GO:0055074 127 0.052
membrane organization GO:0061024 245 0.052
positive regulation of lipid metabolic process GO:0045834 40 0.052
regulation of cell motility GO:2000145 236 0.052
regulation of ras protein signal transduction GO:0046578 114 0.052
rhythmic process GO:0048511 174 0.051
Mouse
organelle fission GO:0048285 170 0.051
purine ribonucleoside metabolic process GO:0046128 241 0.050
alpha amino acid metabolic process GO:1901605 59 0.050
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.049
regulation of intracellular protein transport GO:0033157 82 0.049
cellular response to lipid GO:0071396 145 0.049
metal ion homeostasis GO:0055065 189 0.049
response to decreased oxygen levels GO:0036293 59 0.049
cellular chemical homeostasis GO:0055082 215 0.049
response to inorganic substance GO:0010035 96 0.049
regulation of leukocyte differentiation GO:1902105 159 0.048
hair cycle GO:0042633 90 0.048
positive regulation of glucose metabolic process GO:0010907 21 0.048
negative regulation of cellular protein metabolic process GO:0032269 247 0.048
organophosphate catabolic process GO:0046434 232 0.048
regulation of autophagic vacuole assembly GO:2000785 4 0.048
glycosyl compound catabolic process GO:1901658 206 0.047
calcium ion transport GO:0006816 159 0.047
cellular metal ion homeostasis GO:0006875 151 0.047
microtubule cytoskeleton organization GO:0000226 157 0.046
mammary gland epithelium development GO:0061180 65 0.046
regulation of peptide secretion GO:0002791 77 0.046
regulation of mapk cascade GO:0043408 248 0.046
odontogenesis GO:0042476 78 0.046
regulation of purine nucleotide catabolic process GO:0033121 122 0.045
positive regulation of apoptotic process GO:0043065 217 0.045
positive regulation of protein kinase activity GO:0045860 144 0.045
regulation of gtp catabolic process GO:0033124 113 0.045
carbohydrate derivative catabolic process GO:1901136 231 0.045
reactive oxygen species metabolic process GO:0072593 84 0.045
heart morphogenesis GO:0003007 178 0.045
regulation of hormone secretion GO:0046883 88 0.045
maintenance of location GO:0051235 89 0.044
male germ line stem cell asymmetric division GO:0048133 2 0.044
carboxylic acid catabolic process GO:0046395 51 0.044
carbohydrate biosynthetic process GO:0016051 74 0.044
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.044
cognition GO:0050890 149 0.043
posttranscriptional regulation of gene expression GO:0010608 155 0.043
protein localization to nucleus GO:0034504 121 0.043
regulation of carbohydrate metabolic process GO:0006109 75 0.043
Mouse
protein localization to organelle GO:0033365 185 0.043
circulatory system process GO:0003013 197 0.043
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.042
microtubule based process GO:0007017 236 0.042
adiponectin activated signaling pathway GO:0033211 4 0.042
lipid modification GO:0030258 65 0.042
g protein coupled receptor signaling pathway GO:0007186 243 0.042
regulation of protein localization to nucleus GO:1900180 60 0.042
regulation of cell cycle process GO:0010564 160 0.042
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.042
positive regulation of protein modification process GO:0031401 299 0.042
cellular response to dna damage stimulus GO:0006974 207 0.042
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.041
nuclear import GO:0051170 95 0.041
transmembrane transport GO:0055085 412 0.040
nucleocytoplasmic transport GO:0006913 139 0.040
nuclear division GO:0000280 158 0.040
negative regulation of secretion by cell GO:1903531 54 0.040
negative regulation of cell proliferation GO:0008285 296 0.040
nucleoside metabolic process GO:0009116 246 0.040
regulation of cell migration GO:0030334 219 0.040
reactive oxygen species biosynthetic process GO:1903409 8 0.040
synaptic transmission GO:0007268 329 0.040
purine nucleotide metabolic process GO:0006163 302 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.039
regulation of response to food GO:0032095 10 0.039
vitamin d biosynthetic process GO:0042368 3 0.039
mammary gland duct morphogenesis GO:0060603 38 0.039
neuronal action potential GO:0019228 54 0.039
hematopoietic progenitor cell differentiation GO:0002244 143 0.039
insulin secretion GO:0030073 89 0.039
regulation of reactive oxygen species metabolic process GO:2000377 40 0.038
glutamine family amino acid metabolic process GO:0009064 15 0.038
nucleotide metabolic process GO:0009117 332 0.038
nucleoside phosphate metabolic process GO:0006753 338 0.038
positive regulation of cell growth GO:0030307 33 0.038
cellular response to peptide hormone stimulus GO:0071375 92 0.038
Mouse
ribonucleotide metabolic process GO:0009259 291 0.038
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.038
urogenital system development GO:0001655 261 0.038
response to lipopolysaccharide GO:0032496 128 0.038
germ line stem cell division GO:0042078 2 0.038
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.037
response to nutrient levels GO:0031667 109 0.037
positive regulation of nervous system development GO:0051962 221 0.037
cell type specific apoptotic process GO:0097285 268 0.037
positive regulation of kinase activity GO:0033674 155 0.037
epithelial cell proliferation GO:0050673 174 0.037
nucleoside phosphate catabolic process GO:1901292 222 0.037
carbohydrate homeostasis GO:0033500 128 0.037
carboxylic acid biosynthetic process GO:0046394 86 0.037
rho protein signal transduction GO:0007266 32 0.036
embryonic organ morphogenesis GO:0048562 276 0.036
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.036
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.036
central nervous system neuron differentiation GO:0021953 162 0.036
cellular response to oxidative stress GO:0034599 76 0.036
appendage development GO:0048736 166 0.036
response to monosaccharide GO:0034284 67 0.036
cell fate commitment GO:0045165 210 0.036
ribonucleoside metabolic process GO:0009119 245 0.036
keratinocyte migration GO:0051546 3 0.036
cellular carbohydrate metabolic process GO:0044262 119 0.036
Mouse
negative regulation of peptide hormone secretion GO:0090278 16 0.036
nucleoside triphosphate metabolic process GO:0009141 230 0.036
regulation of fatty acid metabolic process GO:0019217 28 0.036
protein import into nucleus GO:0006606 95 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
negative regulation of map kinase activity GO:0043407 34 0.035
ribonucleotide catabolic process GO:0009261 208 0.035
heterocycle catabolic process GO:0046700 280 0.035
positive regulation of cell cycle GO:0045787 92 0.034
purine nucleoside metabolic process GO:0042278 241 0.034
cellular calcium ion homeostasis GO:0006874 119 0.034
purine nucleoside triphosphate catabolic process GO:0009146 203 0.034
tissue migration GO:0090130 68 0.034
response to extracellular stimulus GO:0009991 127 0.034
cellular response to organic cyclic compound GO:0071407 87 0.034
positive regulation of hydrolase activity GO:0051345 148 0.033
retina development in camera type eye GO:0060041 119 0.033
stem cell differentiation GO:0048863 268 0.033
blood circulation GO:0008015 195 0.033
cellular response to metal ion GO:0071248 31 0.033
regulation of phosphate transport GO:0010966 1 0.033
gland development GO:0048732 330 0.032
neuron migration GO:0001764 122 0.032
regulation of homeostatic process GO:0032844 182 0.032
peptidyl tyrosine phosphorylation GO:0018108 143 0.032
regulation of cell projection organization GO:0031344 206 0.032
morphogenesis of a branching structure GO:0001763 203 0.032
cellular response to amino acid stimulus GO:0071230 29 0.032
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.032
cellular response to acid chemical GO:0071229 68 0.032
placenta development GO:0001890 140 0.032
epithelial cell migration GO:0010631 63 0.032
regulation of transporter activity GO:0032409 57 0.032
cellular divalent inorganic cation homeostasis GO:0072503 127 0.032
response to acid chemical GO:0001101 111 0.032
peptide hormone secretion GO:0030072 109 0.031
protein maturation GO:0051604 176 0.031
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.031
Worm
negative regulation of cytokine production GO:0001818 84 0.031
hair follicle morphogenesis GO:0031069 29 0.031
organic cyclic compound catabolic process GO:1901361 295 0.031
leukocyte differentiation GO:0002521 342 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.031
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.030
regulation of hormone levels GO:0010817 211 0.030
protein processing GO:0016485 163 0.030
negative regulation of cellular component organization GO:0051129 194 0.030
cellular homeostasis GO:0019725 240 0.030
organonitrogen compound biosynthetic process GO:1901566 192 0.030
adult behavior GO:0030534 135 0.030
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.030
nucleoside catabolic process GO:0009164 206 0.030
regulation of system process GO:0044057 200 0.030
t cell activation GO:0042110 289 0.030
ribonucleoside triphosphate metabolic process GO:0009199 220 0.030
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.030
adipose tissue development GO:0060612 25 0.030
organic anion transport GO:0015711 137 0.030
positive regulation of apoptotic signaling pathway GO:2001235 95 0.030
axon ensheathment GO:0008366 76 0.029
dna replication GO:0006260 52 0.029
axonogenesis GO:0007409 274 0.029
fatty acid oxidation GO:0019395 28 0.029
regulation of steroid biosynthetic process GO:0050810 26 0.029
purine containing compound catabolic process GO:0072523 213 0.029
positive regulation of fat cell differentiation GO:0045600 32 0.029
negative regulation of kinase activity GO:0033673 81 0.028
muscle system process GO:0003012 141 0.028
negative regulation of nervous system development GO:0051961 156 0.028
negative regulation of lipid metabolic process GO:0045833 30 0.028
Mouse
ribonucleoside catabolic process GO:0042454 206 0.028
positive regulation of fatty acid oxidation GO:0046321 4 0.028
autophagic vacuole assembly GO:0000045 13 0.028
protein localization to membrane GO:0072657 108 0.028
cellular macromolecule catabolic process GO:0044265 206 0.027
germline stem cell asymmetric division GO:0098728 2 0.027
peptidyl tyrosine modification GO:0018212 145 0.027
macromolecule catabolic process GO:0009057 281 0.027
intermediate filament cytoskeleton organization GO:0045104 26 0.027
neuromuscular process controlling balance GO:0050885 59 0.027
organic hydroxy compound metabolic process GO:1901615 203 0.027
regulation of cytoskeleton organization GO:0051493 122 0.027
positive regulation of cell cycle process GO:0090068 61 0.027
regulation of cell size GO:0008361 72 0.027
response to organic cyclic compound GO:0014070 198 0.027
fertilization GO:0009566 127 0.027
purine ribonucleotide catabolic process GO:0009154 208 0.027
negative regulation of mapk cascade GO:0043409 65 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
protein oligomerization GO:0051259 67 0.026
neuromuscular process GO:0050905 99 0.026
stem cell development GO:0048864 219 0.026
regulation of neuron death GO:1901214 134 0.026
regulation of proteolysis GO:0030162 164 0.026
cellular response to biotic stimulus GO:0071216 92 0.026
regulation of response to oxidative stress GO:1902882 19 0.026
lipid localization GO:0010876 126 0.026
hormone mediated signaling pathway GO:0009755 23 0.026
i kappab kinase nf kappab signaling GO:0007249 85 0.026
glutamate metabolic process GO:0006536 9 0.026
cellular response to starvation GO:0009267 57 0.026
circadian regulation of gene expression GO:0032922 48 0.026
lactation GO:0007595 25 0.026
response to molecule of bacterial origin GO:0002237 143 0.026
purine ribonucleoside catabolic process GO:0046130 205 0.026
epithelium migration GO:0090132 63 0.025
positive regulation of organelle organization GO:0010638 128 0.025
response to hypoxia GO:0001666 58 0.025
cellular response to external stimulus GO:0071496 88 0.025
divalent inorganic cation transport GO:0072511 178 0.025
forebrain development GO:0030900 302 0.025
muscle tissue development GO:0060537 308 0.025
Mouse
hexose biosynthetic process GO:0019319 39 0.025
Mouse
positive regulation of glial cell proliferation GO:0060252 4 0.025
ear development GO:0043583 200 0.025
tissue remodeling GO:0048771 102 0.025
covalent chromatin modification GO:0016569 163 0.025
modification by symbiont of host morphology or physiology GO:0044003 4 0.025
regulation of monooxygenase activity GO:0032768 7 0.025
regulation of glucose transport GO:0010827 32 0.025
reactive nitrogen species metabolic process GO:2001057 0 0.024
muscle cell differentiation GO:0042692 261 0.024
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.024
regulation of lipid biosynthetic process GO:0046890 54 0.024
Mouse
alcohol metabolic process GO:0006066 116 0.024
regulation of cell cycle GO:0051726 281 0.024
Mouse
nucleotide catabolic process GO:0009166 217 0.024
regulation of chromosome organization GO:0033044 83 0.024
regulation of nucleotide metabolic process GO:0006140 169 0.024
purine nucleotide catabolic process GO:0006195 211 0.024
anagen GO:0042640 13 0.024
positive regulation of mapk cascade GO:0043410 170 0.024
positive regulation of cell motility GO:2000147 116 0.024
chromatin modification GO:0016568 187 0.024
telencephalon development GO:0021537 186 0.024
ribose phosphate metabolic process GO:0019693 291 0.024
translation GO:0006412 93 0.024
regulation of purine nucleotide metabolic process GO:1900542 169 0.024
cell growth GO:0016049 130 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.024
lens development in camera type eye GO:0002088 62 0.023
regulation of nucleotide catabolic process GO:0030811 122 0.023
generation of precursor metabolites and energy GO:0006091 103 0.023
striated muscle tissue development GO:0014706 293 0.023
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.023
regulation of cell activation GO:0050865 289 0.023
protein modification by small protein conjugation GO:0032446 187 0.023
extracellular structure organization GO:0043062 148 0.023
lipid transport GO:0006869 98 0.022
fatty acid beta oxidation GO:0006635 16 0.022
response to temperature stimulus GO:0009266 55 0.022
Worm
body fluid secretion GO:0007589 53 0.022
regulation of neuron projection development GO:0010975 169 0.022
regulation of nuclear division GO:0051783 56 0.022
neuron death GO:0070997 154 0.022
photoreceptor cell development GO:0042461 40 0.022
multi multicellular organism process GO:0044706 109 0.022
multicellular organismal response to stress GO:0033555 62 0.022
multicellular organism growth GO:0035264 161 0.022
response to light stimulus GO:0009416 135 0.022
Mouse
eye photoreceptor cell development GO:0042462 31 0.022
response to ph GO:0009268 14 0.022
regulation of ion transmembrane transport GO:0034765 119 0.022
regulation of myeloid cell differentiation GO:0045637 96 0.022
regulation of ras gtpase activity GO:0032318 88 0.021
lymphocyte proliferation GO:0046651 164 0.021
negative regulation of lipid catabolic process GO:0050995 6 0.021
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.021
regulation of actin filament based process GO:0032970 99 0.021
protein secretion GO:0009306 111 0.021
regulation of gliogenesis GO:0014013 50 0.021
myotube differentiation GO:0014902 105 0.021
Mouse
regulation of steroid metabolic process GO:0019218 39 0.021
dicarboxylic acid metabolic process GO:0043648 18 0.021
lymphocyte differentiation GO:0030098 242 0.021
sensory perception GO:0007600 245 0.021
Worm
positive regulation of gtpase activity GO:0043547 85 0.021
lipid biosynthetic process GO:0008610 179 0.021
Mouse
t cell differentiation GO:0030217 174 0.021
regulation of synaptic plasticity GO:0048167 87 0.021
respiratory tube development GO:0030323 167 0.021
oocyte construction GO:0007308 2 0.021
positive regulation of gtp catabolic process GO:0033126 85 0.021
positive regulation of carbohydrate metabolic process GO:0045913 30 0.021
mitotic cell cycle GO:0000278 195 0.021
Mouse
gene silencing GO:0016458 38 0.021
glycosyl compound metabolic process GO:1901657 246 0.021
stress activated protein kinase signaling cascade GO:0031098 81 0.021
skin morphogenesis GO:0043589 38 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.021
positive regulation of protein localization to nucleus GO:1900182 30 0.020
endomembrane system organization GO:0010256 147 0.020
gluconeogenesis GO:0006094 39 0.020
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.020
regulation of stress activated mapk cascade GO:0032872 69 0.020
meiotic nuclear division GO:0007126 115 0.020
guanosine containing compound catabolic process GO:1901069 144 0.020
cell substrate adhesion GO:0031589 130 0.020
gene silencing by rna GO:0031047 19 0.020
skeletal system morphogenesis GO:0048705 203 0.020
pancreas development GO:0031016 57 0.020
positive regulation of cell projection organization GO:0031346 95 0.020
lipid oxidation GO:0034440 29 0.020
positive regulation of map kinase activity GO:0043406 84 0.020

Sik3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.161
nervous system disease DOID:863 0 0.161
musculoskeletal system disease DOID:17 0 0.067
disease of metabolism DOID:0014667 0 0.065
carbohydrate metabolic disorder DOID:2978 0 0.057
inherited metabolic disorder DOID:655 0 0.057
central nervous system disease DOID:331 0 0.045
connective tissue disease DOID:65 0 0.034
brain disease DOID:936 0 0.026
bone disease DOID:0080001 0 0.022
organ system cancer DOID:0050686 0 0.021
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021