Mus musculus

83 known processes

Sim2

single-minded homolog 2 (Drosophila)

(Aliases: bHLHe15)

Sim2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ morphogenesis GO:0048562 276 0.604
Mouse
trachea cartilage morphogenesis GO:0060535 4 0.602
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.601
paraxial mesodermal cell differentiation GO:0048342 2 0.587
aortic valve morphogenesis GO:0003180 4 0.576
central nervous system morphogenesis GO:0021551 2 0.569
canonical wnt signaling pathway GO:0060070 130 0.569
paraxial mesodermal cell fate commitment GO:0048343 2 0.551
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.505
cerebellum formation GO:0021588 1 0.503
mammary gland epithelium development GO:0061180 65 0.497
Mouse
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.489
embryonic skeletal system morphogenesis GO:0048704 91 0.488
hindbrain formation GO:0021576 1 0.482
cartilage development GO:0051216 140 0.467
Mouse
embryonic skeletal system development GO:0048706 120 0.460
skeletal muscle organ development GO:0060538 163 0.459
skeletal system morphogenesis GO:0048705 203 0.445
central nervous system neuron differentiation GO:0021953 162 0.443
cell differentiation in spinal cord GO:0021515 53 0.440
regionalization GO:0003002 337 0.438
auditory receptor cell fate determination GO:0042668 3 0.435
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.428
digestive tract development GO:0048565 190 0.420
Mouse
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.418
nephric duct formation GO:0072179 4 0.418
skeletal muscle cell differentiation GO:0035914 66 0.415
ureteric bud morphogenesis GO:0060675 62 0.411
neuron fate specification GO:0048665 30 0.411
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.408
urogenital system development GO:0001655 261 0.397
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.396
cell fate commitment GO:0045165 210 0.392
Mouse Fly
gas homeostasis GO:0033483 3 0.386
Mouse
protein modification by small protein conjugation GO:0032446 187 0.383
forelimb morphogenesis GO:0035136 40 0.378
developmental maturation GO:0021700 193 0.375
Mouse
striated muscle tissue development GO:0014706 293 0.365
bmp signaling pathway GO:0030509 93 0.363
mesonephric duct formation GO:0072181 2 0.362
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.361
skeletal system development GO:0001501 356 0.351
Mouse
neuron projection guidance GO:0097485 141 0.351
Fly
cellular response to growth factor stimulus GO:0071363 197 0.351
Mouse
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.350
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.348
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.348
pancreatic a cell fate commitment GO:0003326 2 0.347
spinal cord development GO:0021510 81 0.347
tube formation GO:0035148 140 0.345
Mouse
mesonephric duct morphogenesis GO:0072180 4 0.344
ear morphogenesis GO:0042471 118 0.340
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.339
axis elongation involved in somitogenesis GO:0090245 4 0.339
central nervous system neuron development GO:0021954 67 0.335
cardiac right atrium morphogenesis GO:0003213 3 0.333
gland development GO:0048732 330 0.333
Mouse
renal tubule development GO:0061326 87 0.332
appendage morphogenesis GO:0035107 149 0.329
neural tube formation GO:0001841 108 0.322
Mouse
epithelial cell morphogenesis GO:0003382 41 0.322
pancreatic pp cell fate commitment GO:0003329 2 0.321
midbrain hindbrain boundary maturation GO:0021732 1 0.321
tendon formation GO:0035992 4 0.319
axon guidance GO:0007411 141 0.307
Fly
mesonephric tubule development GO:0072164 94 0.307
Mouse
auditory receptor cell fate specification GO:0042667 1 0.302
sensory organ morphogenesis GO:0090596 242 0.302
branching morphogenesis of an epithelial tube GO:0048754 159 0.299
axonogenesis GO:0007409 274 0.296
Fly
regulation of body fluid levels GO:0050878 162 0.291
Mouse
forebrain generation of neurons GO:0021872 63 0.287
nephron tubule development GO:0072080 84 0.286
myotube differentiation GO:0014902 105 0.285
telencephalon development GO:0021537 186 0.283
Mouse
morphogenesis of a polarized epithelium GO:0001738 37 0.282
astrocyte fate commitment GO:0060018 4 0.281
somatotropin secreting cell differentiation GO:0060126 4 0.277
inner ear morphogenesis GO:0042472 101 0.276
regulation of anagen GO:0051884 1 0.275
oxygen homeostasis GO:0032364 2 0.275
Mouse
cation transport GO:0006812 399 0.274
camera type eye development GO:0043010 266 0.272
Mouse
regulation of ureteric bud formation GO:0072106 3 0.271
central nervous system vasculogenesis GO:0022009 3 0.271
tongue development GO:0043586 18 0.268
mitral valve morphogenesis GO:0003183 4 0.263
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000081 1 0.262
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.262
positive regulation of cell development GO:0010720 237 0.261
Mouse
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.261
hemangioblast cell differentiation GO:0060217 1 0.260
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.256
heart morphogenesis GO:0003007 178 0.254
Mouse
cervix development GO:0060067 2 0.252
uterus morphogenesis GO:0061038 2 0.251
olfactory lobe development GO:0021988 32 0.250
regulation of canonical wnt signaling pathway GO:0060828 82 0.250
embryonic appendage morphogenesis GO:0035113 126 0.249
cartilage morphogenesis GO:0060536 11 0.249
metanephric loop of henle development GO:0072236 4 0.247
neural tube development GO:0021915 160 0.246
Mouse
intestinal epithelial cell maturation GO:0060574 2 0.246
Mouse
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.246
renal system development GO:0072001 225 0.241
Mouse
renal inner medulla development GO:0072053 3 0.240
ras protein signal transduction GO:0007265 77 0.237
embryonic limb morphogenesis GO:0030326 126 0.231
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.227
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.225
positive regulation of anagen GO:0051885 1 0.222
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.222
Mouse
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.220
embryonic epithelial tube formation GO:0001838 130 0.220
Mouse
limb development GO:0060173 166 0.220
epidermis development GO:0008544 187 0.220
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.219
cerebral cortex development GO:0021987 86 0.219
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.218
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.218
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.217
inner medullary collecting duct development GO:0072061 2 0.215
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.215
gliogenesis GO:0042063 141 0.214
tendon cell differentiation GO:0035990 4 0.214
stem cell differentiation GO:0048863 268 0.213
Mouse
mesenchyme development GO:0060485 152 0.213
Mouse
kidney epithelium development GO:0072073 121 0.210
Mouse
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.210
glial cell differentiation GO:0010001 131 0.207
mesenchymal cell development GO:0014031 93 0.207
Mouse
forebrain neuron fate commitment GO:0021877 13 0.207
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.206
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.206
branching involved in ureteric bud morphogenesis GO:0001658 56 0.205
skin development GO:0043588 220 0.204
mesonephric tubule morphogenesis GO:0072171 63 0.204
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.202
myeloid cell differentiation GO:0030099 233 0.202
Mouse
epithelial tube morphogenesis GO:0060562 303 0.202
Mouse
regulation of system process GO:0044057 200 0.202
Mouse
forebrain development GO:0030900 302 0.201
Mouse
lung induction GO:0060492 3 0.200
establishment of organ orientation GO:0048561 1 0.199
endocrine system development GO:0035270 98 0.197
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.196
somitogenesis GO:0001756 69 0.195
transdifferentiation GO:0060290 1 0.195
cerebellum development GO:0021549 77 0.193
regulation of exit from mitosis GO:0007096 1 0.192
spemann organizer formation GO:0060061 2 0.191
oviduct development GO:0060066 3 0.191
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.191
regulation of organ formation GO:0003156 34 0.191
developmental growth involved in morphogenesis GO:0060560 138 0.190
mitral valve development GO:0003174 4 0.189
morphogenesis of a branching epithelium GO:0061138 193 0.188
outer medullary collecting duct development GO:0072060 1 0.187
ureteric bud development GO:0001657 94 0.187
Mouse
blood circulation GO:0008015 195 0.187
Mouse
diencephalon development GO:0021536 63 0.183
pancreatic pp cell differentiation GO:0003312 2 0.180
cell fate determination GO:0001709 32 0.179
epithelial tube formation GO:0072175 130 0.178
Mouse
midbrain development GO:0030901 35 0.177
regulation of cell cycle GO:0051726 281 0.177
regulation of epithelial cell proliferation GO:0050678 141 0.175
cell fate specification GO:0001708 72 0.175
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.174
negative regulation of testosterone biosynthetic process GO:2000225 1 0.174
nephron epithelium morphogenesis GO:0072088 68 0.174
protein ubiquitination GO:0016567 171 0.173
embryonic heart tube formation GO:0003144 1 0.173
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.173
olfactory bulb development GO:0021772 30 0.173
cardiac muscle tissue morphogenesis GO:0055008 44 0.172
regulation of cellular amino acid metabolic process GO:0006521 5 0.172
renal tubule morphogenesis GO:0061333 72 0.172
renal outer medulla development GO:0072054 2 0.172
kidney morphogenesis GO:0060993 83 0.171
renal vesicle induction GO:0072034 3 0.171
wnt signaling pathway calcium modulating pathway GO:0007223 2 0.171
wnt signaling pathway GO:0016055 188 0.170
stress activated mapk cascade GO:0051403 80 0.170
ventral spinal cord development GO:0021517 48 0.169
nephron epithelium development GO:0072009 92 0.169
cardiac muscle tissue development GO:0048738 130 0.168
regulation of interleukin 8 secretion GO:2000482 2 0.166
regulation of organ morphogenesis GO:2000027 144 0.166
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.165
mesonephric epithelium development GO:0072163 94 0.165
Mouse
cell proliferation involved in heart valve development GO:2000793 2 0.165
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.165
regulation of neuron projection development GO:0010975 169 0.164
regulation of retina development in camera type eye GO:1902866 3 0.163
somite development GO:0061053 81 0.162
odontogenesis GO:0042476 78 0.162
positive regulation of neuron differentiation GO:0045666 141 0.161
kidney development GO:0001822 213 0.161
Mouse
forebrain regionalization GO:0021871 25 0.161
neural fold elevation formation GO:0021502 1 0.160
Mouse
glandular epithelial cell differentiation GO:0002067 38 0.160
visceral serous pericardium development GO:0061032 2 0.160
stem cell maintenance GO:0019827 130 0.159
neural tube closure GO:0001843 90 0.159
auditory receptor cell differentiation GO:0042491 37 0.159
negative regulation of neuron death GO:1901215 98 0.158
Mouse
regulation of auditory receptor cell differentiation GO:0045607 4 0.158
negative regulation of intracellular signal transduction GO:1902532 167 0.158
Mouse
muscle tissue morphogenesis GO:0060415 53 0.158
purine nucleoside triphosphate catabolic process GO:0009146 203 0.157
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.157
cardiac chamber morphogenesis GO:0003206 93 0.156
Mouse
bone development GO:0060348 120 0.156
segmentation GO:0035282 93 0.155
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.154
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.154
mesoderm development GO:0007498 100 0.154
foregut regionalization GO:0060423 3 0.153
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.153
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.153
appendage development GO:0048736 166 0.151
positive regulation of ureteric bud formation GO:0072107 3 0.151
peripheral nervous system neuron axonogenesis GO:0048936 3 0.150
organic cyclic compound catabolic process GO:1901361 295 0.150
morphogenesis of an epithelial fold GO:0060571 28 0.150
Mouse
amine metabolic process GO:0009308 45 0.147
regulation of neural retina development GO:0061074 3 0.145
lung development GO:0030324 164 0.144
kidney rudiment formation GO:0072003 3 0.143
ossification GO:0001503 216 0.143
Mouse
stem cell development GO:0048864 219 0.143
Mouse
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.143
neural retina development GO:0003407 41 0.142
nephron tubule morphogenesis GO:0072078 68 0.141
metanephros development GO:0001656 79 0.141
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.141
dopaminergic neuron differentiation GO:0071542 14 0.139
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.139
chondrocyte differentiation GO:0002062 72 0.139
spinal cord association neuron differentiation GO:0021527 14 0.139
establishment of anatomical structure orientation GO:0048560 1 0.139
ventral spinal cord interneuron fate commitment GO:0060579 14 0.138
positive regulation of growth GO:0045927 104 0.137
cardiac ventricle development GO:0003231 83 0.137
Mouse
epithelial to mesenchymal transition GO:0001837 47 0.137
Mouse
regulation of cell projection organization GO:0031344 206 0.137
cardiac right ventricle formation GO:0003219 3 0.136
protein processing GO:0016485 163 0.136
hindbrain development GO:0030902 128 0.135
regulation of wnt signaling pathway GO:0030111 123 0.135
nucleoside catabolic process GO:0009164 206 0.135
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.135
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.135
ribonucleoside catabolic process GO:0042454 206 0.134
modification dependent macromolecule catabolic process GO:0043632 133 0.134
mesonephros development GO:0001823 97 0.133
Mouse
regulation of testosterone biosynthetic process GO:2000224 2 0.132
cellular amine metabolic process GO:0044106 44 0.131
forebrain neuron differentiation GO:0021879 52 0.130
hair cell differentiation GO:0035315 40 0.130
molting cycle GO:0042303 90 0.129
nephron development GO:0072006 109 0.128
mammary gland morphogenesis GO:0060443 54 0.127
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.127
syncytium formation by plasma membrane fusion GO:0000768 42 0.127
head morphogenesis GO:0060323 34 0.127
regulation of neuron differentiation GO:0045664 281 0.126
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.126
mesonephric tubule formation GO:0072172 11 0.125
ribonucleotide catabolic process GO:0009261 208 0.125
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.125
circulatory system process GO:0003013 197 0.124
Mouse
respiratory system development GO:0060541 190 0.124
neuron fate determination GO:0048664 9 0.123
connective tissue development GO:0061448 179 0.123
Mouse
muscle tissue development GO:0060537 308 0.123
outflow tract morphogenesis GO:0003151 53 0.123
Mouse
columnar cuboidal epithelial cell maturation GO:0002069 4 0.121
Mouse
regulation of purine nucleotide catabolic process GO:0033121 122 0.120
b cell activation GO:0042113 161 0.120
transmembrane transport GO:0055085 412 0.119
ear development GO:0043583 200 0.119
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.119
myeloid leukocyte differentiation GO:0002573 119 0.119
nephron morphogenesis GO:0072028 69 0.118
protein maturation GO:0051604 176 0.116
purine nucleoside triphosphate metabolic process GO:0009144 226 0.116
glycosyl compound metabolic process GO:1901657 246 0.116
hypophysis morphogenesis GO:0048850 3 0.115
regulation of mesonephros development GO:0061217 24 0.115
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.114
mitotic cell cycle GO:0000278 195 0.114
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.113
embryonic forelimb morphogenesis GO:0035115 32 0.112
cell division GO:0051301 120 0.112
regulation of nucleotide metabolic process GO:0006140 169 0.111
non canonical wnt signaling pathway via jnk cascade GO:0038031 3 0.111
negative regulation of molecular function GO:0044092 258 0.110
aromatic compound catabolic process GO:0019439 286 0.110
limbic system development GO:0021761 72 0.109
positive regulation of apoptotic process GO:0043065 217 0.109
definitive hemopoiesis GO:0060216 20 0.109
negative regulation of prostatic bud formation GO:0060686 4 0.109
nucleotide catabolic process GO:0009166 217 0.108
metencephalon development GO:0022037 89 0.108
regulation of bmp signaling pathway GO:0030510 60 0.107
organelle localization GO:0051640 179 0.107
cellular ketone metabolic process GO:0042180 84 0.106
lung field specification GO:0060424 3 0.106
sclerotome development GO:0061056 4 0.105
establishment or maintenance of cell polarity GO:0007163 86 0.105
hormone metabolic process GO:0042445 86 0.105
odontogenesis of dentin containing tooth GO:0042475 66 0.104
neuroblast differentiation GO:0014016 2 0.104
positive regulation of synaptic plasticity GO:0031915 4 0.103
negative regulation of wnt signaling pathway GO:0030178 73 0.103
epithelial cell proliferation GO:0050673 174 0.103
small gtpase mediated signal transduction GO:0007264 97 0.102
cell proliferation in forebrain GO:0021846 30 0.102
regulation of transforming growth factor beta2 production GO:0032909 2 0.102
hematopoietic progenitor cell differentiation GO:0002244 143 0.102
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.100
spleen development GO:0048536 39 0.100
body morphogenesis GO:0010171 45 0.100
neuronal action potential GO:0019228 54 0.100
heart formation GO:0060914 16 0.099
epithelial cell development GO:0002064 159 0.099
Mouse
cardiac ventricle morphogenesis GO:0003208 50 0.099
Mouse
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.099
respiratory tube development GO:0030323 167 0.098
positive regulation of cell cell adhesion mediated by cadherin GO:2000049 2 0.098
neuron apoptotic process GO:0051402 142 0.098
Mouse
pallium development GO:0021543 120 0.097
Mouse
establishment of planar polarity GO:0001736 28 0.097
mechanoreceptor differentiation GO:0042490 67 0.096
mesenchymal cell proliferation GO:0010463 44 0.096
response to growth factor GO:0070848 198 0.096
Mouse
dorsal spinal cord development GO:0021516 20 0.096
morphogenesis of embryonic epithelium GO:0016331 159 0.096
Mouse
establishment of endothelial blood brain barrier GO:0014045 3 0.096
positive regulation of keratinocyte proliferation GO:0010838 4 0.096
glycosyl compound catabolic process GO:1901658 206 0.096
pericardium development GO:0060039 16 0.095
negative regulation of synapse assembly GO:0051964 3 0.095
metanephric renal vesicle morphogenesis GO:0072283 12 0.095
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.095
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.095
cell type specific apoptotic process GO:0097285 268 0.095
Mouse
tube closure GO:0060606 91 0.095
bronchiole development GO:0060435 3 0.095
nuclear division GO:0000280 158 0.093
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.093
mesenchymal to epithelial transition GO:0060231 12 0.093
positive regulation of neuron projection development GO:0010976 79 0.093
chemotaxis GO:0006935 247 0.092
Fly
hindbrain morphogenesis GO:0021575 46 0.092
male gonad development GO:0008584 88 0.092
regulation of nucleotide catabolic process GO:0030811 122 0.092
negative regulation of cellular protein metabolic process GO:0032269 247 0.092
cell proliferation in hindbrain GO:0021534 10 0.091
maintenance of cell number GO:0098727 3 0.090
negative regulation of androgen biosynthetic process GO:2000180 1 0.090
regulation of hydrolase activity GO:0051336 246 0.090
regulation of nucleoside metabolic process GO:0009118 130 0.090
hindlimb morphogenesis GO:0035137 42 0.089
microtubule based process GO:0007017 236 0.089
muscle cell development GO:0055001 133 0.089
limb morphogenesis GO:0035108 149 0.089
purine containing compound catabolic process GO:0072523 213 0.089
neuroblast proliferation GO:0007405 49 0.089
Mouse
regulation of proteolysis GO:0030162 164 0.088
positive regulation of wnt signaling pathway GO:0030177 45 0.088
regulation of mast cell differentiation GO:0060375 3 0.088
regulation of mesenchymal cell proliferation GO:0010464 37 0.088
hair follicle development GO:0001942 85 0.087
cell maturation GO:0048469 127 0.087
Mouse
cerebellum morphogenesis GO:0021587 42 0.087
regulation of axon extension GO:0030516 43 0.087
neuron projection extension GO:1990138 64 0.087
regulation of cell cycle process GO:0010564 160 0.086
regulation of cellular amine metabolic process GO:0033238 20 0.086
male gamete generation GO:0048232 285 0.086
cardiocyte differentiation GO:0035051 87 0.086
mammary gland duct morphogenesis GO:0060603 38 0.085
ubiquitin dependent protein catabolic process GO:0006511 129 0.085
modification dependent protein catabolic process GO:0019941 133 0.085
regulation of fibroblast growth factor production GO:0090270 4 0.085
pharynx development GO:0060465 1 0.084
negative regulation of nervous system development GO:0051961 156 0.084
cranial nerve development GO:0021545 41 0.084
establishment or maintenance of polarity of embryonic epithelium GO:0016332 1 0.083
nucleoside phosphate metabolic process GO:0006753 338 0.083
ribonucleoside triphosphate catabolic process GO:0009203 199 0.083
inorganic ion transmembrane transport GO:0098660 234 0.083
protein targeting GO:0006605 143 0.082
anion transport GO:0006820 177 0.082
negative regulation of myeloid cell differentiation GO:0045638 38 0.082
carbohydrate metabolic process GO:0005975 230 0.082
Mouse
non canonical wnt signaling pathway GO:0035567 33 0.082
androgen biosynthetic process GO:0006702 4 0.081
visceral motor neuron differentiation GO:0021524 3 0.081
non canonical wnt signaling pathway via mapk cascade GO:0038030 3 0.081
retina development in camera type eye GO:0060041 119 0.081
Mouse
nucleocytoplasmic transport GO:0006913 139 0.081
peripheral nervous system neuron development GO:0048935 9 0.081
regulation of ras gtpase activity GO:0032318 88 0.081
gonad development GO:0008406 141 0.080
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.080
regulation of cartilage development GO:0061035 44 0.079
cell cycle arrest GO:0007050 37 0.079
lung epithelium development GO:0060428 37 0.078
negative regulation of cellular amine metabolic process GO:0033239 1 0.077
actin filament organization GO:0007015 113 0.077
muscle cell differentiation GO:0042692 261 0.077
Mouse
pattern specification involved in metanephros development GO:0072268 4 0.076
nucleotide metabolic process GO:0009117 332 0.076
negative regulation of cell cycle GO:0045786 123 0.076
regulation of binding GO:0051098 111 0.075
regulation of axon diameter GO:0031133 6 0.075
cation transmembrane transport GO:0098655 266 0.075
muscle system process GO:0003012 141 0.075
regulation of hormone levels GO:0010817 211 0.075
Mouse
lung epithelial cell differentiation GO:0060487 29 0.074
apoptotic signaling pathway GO:0097190 306 0.074
polarity specification of proximal distal axis GO:0010085 2 0.074
paramesonephric duct development GO:0061205 3 0.073
endocrine pancreas development GO:0031018 29 0.073
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.073
cytokine production GO:0001816 319 0.073
muscle fiber development GO:0048747 76 0.073
cell cell signaling involved in cell fate commitment GO:0045168 35 0.072
transforming growth factor beta2 production GO:0032906 2 0.072
purine ribonucleoside metabolic process GO:0046128 241 0.072
nucleoside phosphate catabolic process GO:1901292 222 0.072
spinal cord motor neuron differentiation GO:0021522 35 0.072
positive regulation of transforming growth factor beta2 production GO:0032915 2 0.072
mammary gland epithelial cell proliferation GO:0033598 24 0.072
motor neuron migration GO:0097475 4 0.071
nerve development GO:0021675 67 0.071
regulation of cellular catabolic process GO:0031329 242 0.071
Mouse
specification of organ identity GO:0010092 30 0.071
establishment of planar polarity of embryonic epithelium GO:0042249 16 0.071
regulation of ketone biosynthetic process GO:0010566 2 0.070
body fluid secretion GO:0007589 53 0.070
Mouse
deltoid tuberosity development GO:0035993 3 0.070
rhythmic process GO:0048511 174 0.070
ectoderm formation GO:0001705 3 0.070
adult locomotory behavior GO:0008344 91 0.070
Fly
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.070
establishment of tissue polarity GO:0007164 28 0.070
regulation of establishment of planar polarity GO:0090175 28 0.070
cellular response to inorganic substance GO:0071241 37 0.070
cellular amino acid metabolic process GO:0006520 103 0.070
positive regulation of smoothened signaling pathway GO:0045880 23 0.070
negative regulation of synapse maturation GO:2000297 2 0.069
regulation of mitotic cell cycle GO:0007346 126 0.069
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.069
cellular response to organonitrogen compound GO:0071417 145 0.069
negative regulation of oxidative phosphorylation uncoupler activity GO:2000276 2 0.069
heterocycle catabolic process GO:0046700 280 0.069
negative regulation of bmp signaling pathway GO:0030514 35 0.069
response to organic cyclic compound GO:0014070 198 0.068
mammary gland lobule development GO:0061377 22 0.068
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.068
Mouse
regulation of neuron apoptotic process GO:0043523 122 0.068
Mouse
extracellular structure organization GO:0043062 148 0.068
cardiac chamber development GO:0003205 108 0.068
Mouse
regulation of kidney development GO:0090183 40 0.068
regulation of myeloid cell differentiation GO:0045637 96 0.068
Mouse
primary neural tube formation GO:0014020 95 0.067
Mouse
lipid localization GO:0010876 126 0.067
endocardial cushion to mesenchymal transition GO:0090500 5 0.067
positive regulation of branching involved in lung morphogenesis GO:0061047 4 0.067
cardiac epithelial to mesenchymal transition GO:0060317 18 0.067
negative regulation of protein modification process GO:0031400 163 0.066
apoptotic process involved in development GO:1902742 28 0.066
organelle fission GO:0048285 170 0.066
cytoplasmic transport GO:0016482 234 0.066
amacrine cell differentiation GO:0035881 5 0.066
collagen metabolic process GO:0032963 17 0.066
Mouse
cerebellar cortex formation GO:0021697 22 0.066
inner ear receptor cell differentiation GO:0060113 61 0.066
mitochondrion distribution GO:0048311 4 0.066
negative regulation of ossification GO:0030279 49 0.065
Mouse
regulation of establishment of planar polarity involved in neural tube closure GO:0090178 15 0.065
positive regulation of cell death GO:0010942 224 0.065
developmental programmed cell death GO:0010623 41 0.065
negative regulation of hormone metabolic process GO:0032351 4 0.065
purine containing compound metabolic process GO:0072521 311 0.065
thymus development GO:0048538 41 0.065
lobar bronchus development GO:0060482 6 0.065
cell differentiation in hindbrain GO:0021533 24 0.065
steroid metabolic process GO:0008202 119 0.065
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.064
blastocyst formation GO:0001825 33 0.064
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.064

Sim2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.109
musculoskeletal system disease DOID:17 0 0.109