Mus musculus

58 known processes

Sirt3

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

(Aliases: 2310003L23Rik,AI848213,Sir2l3)

Sirt3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
coenzyme metabolic process GO:0006732 52 0.553
acetate metabolic process GO:0006083 1 0.442
cellular amino acid metabolic process GO:0006520 103 0.374
oxidation reduction process GO:0055114 342 0.355
Human
monocarboxylic acid metabolic process GO:0032787 191 0.254
coenzyme biosynthetic process GO:0009108 23 0.206
cofactor metabolic process GO:0051186 80 0.197
nucleobase containing small molecule metabolic process GO:0055086 352 0.196
cellular aldehyde metabolic process GO:0006081 12 0.187
small molecule biosynthetic process GO:0044283 132 0.184
carboxylic acid biosynthetic process GO:0046394 86 0.145
amine metabolic process GO:0009308 45 0.123
cellular lipid metabolic process GO:0044255 323 0.120
Mouse
cellular amine metabolic process GO:0044106 44 0.112
ketone catabolic process GO:0042182 3 0.111
cellular amino acid biosynthetic process GO:0008652 22 0.091
9 cis retinoic acid metabolic process GO:0042905 5 0.086
lipid biosynthetic process GO:0008610 179 0.084
organonitrogen compound biosynthetic process GO:1901566 192 0.083
regulation of cellular ketone metabolic process GO:0010565 66 0.078
nadh metabolic process GO:0006734 1 0.076
organic acid biosynthetic process GO:0016053 86 0.076
cellular ketone metabolic process GO:0042180 84 0.074
sulfur compound biosynthetic process GO:0044272 37 0.071
response to organonitrogen compound GO:0010243 246 0.070
Mouse
response to testosterone GO:0033574 3 0.067
diterpenoid metabolic process GO:0016101 24 0.067
renal system development GO:0072001 225 0.064
energy derivation by oxidation of organic compounds GO:0015980 77 0.063
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.061
cellular modified amino acid metabolic process GO:0006575 63 0.058
polyamine catabolic process GO:0006598 2 0.056
sulfur compound metabolic process GO:0006790 100 0.053
iron sulfur cluster assembly GO:0016226 3 0.052
cofactor biosynthetic process GO:0051188 41 0.051
apoptotic signaling pathway GO:0097190 306 0.048
muscle tissue development GO:0060537 308 0.047
striated muscle tissue development GO:0014706 293 0.046
retinoid metabolic process GO:0001523 24 0.046
regulation of response to drug GO:2001023 2 0.046
nucleoside phosphate metabolic process GO:0006753 338 0.045
oxidoreduction coenzyme metabolic process GO:0006733 16 0.045
glutathione metabolic process GO:0006749 16 0.044
organic hydroxy compound metabolic process GO:1901615 203 0.043
generation of precursor metabolites and energy GO:0006091 103 0.042
Human
morphogenesis of embryonic epithelium GO:0016331 159 0.041
gland development GO:0048732 330 0.039
nucleotide metabolic process GO:0009117 332 0.037
embryonic organ morphogenesis GO:0048562 276 0.036
positive regulation of cellular amine metabolic process GO:0033240 5 0.036
response to oxygen levels GO:0070482 62 0.036
small molecule catabolic process GO:0044282 71 0.036
isoprenoid metabolic process GO:0006720 29 0.036
camera type eye development GO:0043010 266 0.035
fat cell differentiation GO:0045444 160 0.034
Mouse
diterpenoid biosynthetic process GO:0016102 7 0.034
carbohydrate metabolic process GO:0005975 230 0.034
sensory organ morphogenesis GO:0090596 242 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
regulation of hormone levels GO:0010817 211 0.032
Rat
cardiac muscle tissue development GO:0048738 130 0.032
maintenance of location GO:0051235 89 0.031
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.031
developmental maturation GO:0021700 193 0.031
Mouse
heart morphogenesis GO:0003007 178 0.030
urogenital system development GO:0001655 261 0.029
digestive tract development GO:0048565 190 0.028
response to organic cyclic compound GO:0014070 198 0.028
Mouse
digestive system development GO:0055123 200 0.028
regulation of cellular amine metabolic process GO:0033238 20 0.028
nonribosomal peptide biosynthetic process GO:0019184 5 0.028
branched chain amino acid catabolic process GO:0009083 2 0.027
response to hyperoxia GO:0055093 2 0.026
regulation of protein kinase activity GO:0045859 232 0.026
response to molecule of bacterial origin GO:0002237 143 0.025
ethanol metabolic process GO:0006067 3 0.025
multicellular organismal homeostasis GO:0048871 164 0.024
hormone metabolic process GO:0042445 86 0.024
microtubule cytoskeleton organization GO:0000226 157 0.023
Mouse
terpenoid metabolic process GO:0006721 25 0.023
rhythmic process GO:0048511 174 0.023
alcohol metabolic process GO:0006066 116 0.023
ribonucleoside metabolic process GO:0009119 245 0.022
appendage development GO:0048736 166 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
microtubule based process GO:0007017 236 0.022
Mouse
regulation of organelle organization GO:0033043 289 0.022
Mouse
limb development GO:0060173 166 0.022
regulation of membrane potential GO:0042391 192 0.022
Mouse
transmembrane transport GO:0055085 412 0.021
liver development GO:0001889 66 0.021
cellular response to acid chemical GO:0071229 68 0.021
monocarboxylic acid biosynthetic process GO:0072330 61 0.021
peptide metabolic process GO:0006518 46 0.021
ribonucleotide metabolic process GO:0009259 291 0.021
response to lipopolysaccharide GO:0032496 128 0.021
ear morphogenesis GO:0042471 118 0.020
thioester metabolic process GO:0035383 19 0.020
quinone metabolic process GO:1901661 7 0.020
nadph regeneration GO:0006740 2 0.020
pyruvate metabolic process GO:0006090 28 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
development of primary female sexual characteristics GO:0046545 73 0.019
limb morphogenesis GO:0035108 149 0.019
positive regulation of protein modification process GO:0031401 299 0.019
purine ribonucleotide metabolic process GO:0009150 290 0.019
forebrain development GO:0030900 302 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.019
negative regulation of cellular component organization GO:0051129 194 0.019
Mouse
hepaticobiliary system development GO:0061008 67 0.018
response to extracellular stimulus GO:0009991 127 0.018
Mouse
metallo sulfur cluster assembly GO:0031163 3 0.018
macromolecule catabolic process GO:0009057 281 0.018
Mouse
muscle cell differentiation GO:0042692 261 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
myeloid leukocyte migration GO:0097529 57 0.017
response to growth factor GO:0070848 198 0.017
response to nutrient levels GO:0031667 109 0.017
Mouse
kidney development GO:0001822 213 0.017
primary alcohol metabolic process GO:0034308 11 0.017
locomotory behavior GO:0007626 195 0.017
response to steroid hormone GO:0048545 56 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.017
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
Mouse
positive regulation of programmed cell death GO:0043068 218 0.017
Mouse
lung development GO:0030324 164 0.017
response to acid chemical GO:0001101 111 0.017
ear development GO:0043583 200 0.017
response to increased oxygen levels GO:0036296 2 0.016
nicotinamide nucleotide metabolic process GO:0046496 12 0.016
leukocyte migration GO:0050900 124 0.016
negative regulation of protein modification process GO:0031400 163 0.016
neural nucleus development GO:0048857 22 0.016
homeostasis of number of cells GO:0048872 210 0.016
cellular macromolecule catabolic process GO:0044265 206 0.016
Mouse
protein localization to organelle GO:0033365 185 0.016
nucleoside metabolic process GO:0009116 246 0.016
tissue homeostasis GO:0001894 115 0.016
pyridine nucleotide metabolic process GO:0019362 12 0.016
positive regulation of cell death GO:0010942 224 0.016
Mouse
purine containing compound metabolic process GO:0072521 311 0.015
retinoic acid metabolic process GO:0042573 12 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
transmission of nerve impulse GO:0019226 76 0.015
Mouse
nucleoside triphosphate metabolic process GO:0009141 230 0.015
inner ear morphogenesis GO:0042472 101 0.015
female sex differentiation GO:0046660 84 0.015
substantia nigra development GO:0021762 2 0.015
epithelial cell proliferation GO:0050673 174 0.015
neuromuscular process GO:0050905 99 0.015
regulation of transferase activity GO:0051338 263 0.015
cytokine production GO:0001816 319 0.015
nitrogen compound transport GO:0071705 271 0.015
Rat
aldehyde catabolic process GO:0046185 4 0.015
skin development GO:0043588 220 0.015
respiratory system development GO:0060541 190 0.015
myeloid cell differentiation GO:0030099 233 0.014
olfactory pit development GO:0060166 3 0.014
regionalization GO:0003002 337 0.014
embryonic appendage morphogenesis GO:0035113 126 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
aromatic compound catabolic process GO:0019439 286 0.014
steroid metabolic process GO:0008202 119 0.014
9 cis retinoic acid biosynthetic process GO:0042904 5 0.014
regulation of cytokine production GO:0001817 266 0.014
cellular protein complex assembly GO:0043623 116 0.014
Mouse
terpenoid biosynthetic process GO:0016114 7 0.014
protein maturation GO:0051604 176 0.013
neuromuscular process controlling balance GO:0050885 59 0.013
embryonic limb morphogenesis GO:0030326 126 0.013
cellular response to lipid GO:0071396 145 0.013
sensory perception GO:0007600 245 0.013
retinoic acid biosynthetic process GO:0002138 7 0.013
asymmetric stem cell division GO:0098722 3 0.013
stem cell development GO:0048864 219 0.013
mesenchyme development GO:0060485 152 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
regulation of interleukin 8 production GO:0032677 3 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
cellular amide metabolic process GO:0043603 58 0.013
respiratory tube development GO:0030323 167 0.013
neuronal action potential GO:0019228 54 0.013
Mouse
mapk cascade GO:0000165 281 0.013
Rat
stem cell differentiation GO:0048863 268 0.013
asymmetric neuroblast division GO:0055059 1 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
Mouse Rat
regulation of kinase activity GO:0043549 249 0.012
cellular carbohydrate metabolic process GO:0044262 119 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
Mouse Rat
purine ribonucleoside metabolic process GO:0046128 241 0.012
chemotaxis GO:0006935 247 0.012
organic cyclic compound catabolic process GO:1901361 295 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.012
limbic system development GO:0021761 72 0.012
cell type specific apoptotic process GO:0097285 268 0.012
epithelial cell development GO:0002064 159 0.012
nucleus accumbens development GO:0021768 1 0.012
anatomical structure homeostasis GO:0060249 145 0.012
regulation of anatomical structure size GO:0090066 178 0.012
multicellular organismal signaling GO:0035637 91 0.012
Mouse
lateral inhibition GO:0046331 1 0.012
striatum development GO:0021756 14 0.012
bone development GO:0060348 120 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
cellular modified amino acid biosynthetic process GO:0042398 12 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
Rat
pancreas development GO:0031016 57 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
mitochondrion degradation GO:0000422 3 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
Mouse Rat
male gamete generation GO:0048232 285 0.011
female gonad development GO:0008585 71 0.011
response to light stimulus GO:0009416 135 0.011
peptidyl amino acid modification GO:0018193 336 0.011
ensheathment of neurons GO:0007272 76 0.011
Mouse
nucleotide catabolic process GO:0009166 217 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
Mouse Rat
lipid storage GO:0019915 36 0.011
telencephalon development GO:0021537 186 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
skeletal system development GO:0001501 356 0.011
pyruvate transport GO:0006848 2 0.011
ovulation cycle GO:0042698 59 0.011
action potential GO:0001508 78 0.011
Mouse
connective tissue development GO:0061448 179 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
Mouse
circulatory system process GO:0003013 197 0.010
response to retinoic acid GO:0032526 56 0.010
negative regulation of phosphate metabolic process GO:0045936 184 0.010
Mouse Rat
protein catabolic process GO:0030163 221 0.010
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.010
Mouse
cation transmembrane transport GO:0098655 266 0.010
muscle system process GO:0003012 141 0.010
glycosyl compound catabolic process GO:1901658 206 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
Mouse
embryonic epithelial tube formation GO:0001838 130 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
anatomical structure maturation GO:0071695 49 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
retinal metabolic process GO:0042574 5 0.010
response to alcohol GO:0097305 48 0.010
neuron apoptotic process GO:0051402 142 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
small gtpase mediated signal transduction GO:0007264 97 0.010
purine nucleoside triphosphate metabolic process GO:0009144 226 0.010
pyridine containing compound metabolic process GO:0072524 14 0.010
intracellular receptor signaling pathway GO:0030522 74 0.010
nephron development GO:0072006 109 0.010
carbohydrate derivative catabolic process GO:1901136 231 0.010

Sirt3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.030
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
inherited metabolic disorder DOID:655 0 0.018
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010