Mus musculus

235 known processes

Six2

sine oculis-related homeobox 2 homolog (Drosophila)

Six2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
skeletal system development GO:0001501 356 0.933
skeletal system morphogenesis GO:0048705 203 0.883
forebrain development GO:0030900 302 0.883
Mouse
cartilage development GO:0051216 140 0.879
regionalization GO:0003002 337 0.877
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.875
Mouse
diencephalon development GO:0021536 63 0.871
Mouse
mesoderm development GO:0007498 100 0.868
stem cell differentiation GO:0048863 268 0.852
central nervous system neuron differentiation GO:0021953 162 0.808
digestive tract development GO:0048565 190 0.799
kidney epithelium development GO:0072073 121 0.756
embryonic organ morphogenesis GO:0048562 276 0.750
embryonic skeletal system morphogenesis GO:0048704 91 0.722
sensory organ morphogenesis GO:0090596 242 0.713
positive regulation of cell development GO:0010720 237 0.709
connective tissue development GO:0061448 179 0.684
cell differentiation in spinal cord GO:0021515 53 0.684
regulation of organ morphogenesis GO:2000027 144 0.678
lymphocyte differentiation GO:0030098 242 0.675
ventral spinal cord interneuron differentiation GO:0021514 16 0.670
striated muscle tissue development GO:0014706 293 0.659
Mouse
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.652
embryonic skeletal system development GO:0048706 120 0.642
stem cell development GO:0048864 219 0.640
mesenchymal cell differentiation GO:0048762 107 0.617
regulation of neuron differentiation GO:0045664 281 0.608
Mouse
t cell differentiation GO:0030217 174 0.599
spinal cord development GO:0021510 81 0.597
positive regulation of neuron differentiation GO:0045666 141 0.577
negative regulation of cell proliferation GO:0008285 296 0.570
Mouse
neuron fate specification GO:0048665 30 0.567
Mouse
stem cell maintenance GO:0019827 130 0.563
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.559
gland development GO:0048732 330 0.559
Mouse Fly
cell fate commitment GO:0045165 210 0.551
neuron projection guidance GO:0097485 141 0.538
forebrain generation of neurons GO:0021872 63 0.533
mesenchymal cell development GO:0014031 93 0.527
negative regulation of nervous system development GO:0051961 156 0.524
Mouse
epidermis development GO:0008544 187 0.521
nephron tubule morphogenesis GO:0072078 68 0.511
paraxial mesodermal cell fate commitment GO:0048343 2 0.510
subpallium neuron fate commitment GO:0060163 2 0.508
muscle tissue development GO:0060537 308 0.505
Mouse
digestive system development GO:0055123 200 0.491
blood vessel morphogenesis GO:0048514 285 0.484
Mouse
neural tube formation GO:0001841 108 0.467
negative regulation of neuron differentiation GO:0045665 101 0.461
Mouse
limb morphogenesis GO:0035108 149 0.456
mesonephric tubule development GO:0072164 94 0.447
ureteric bud development GO:0001657 94 0.435
pyramidal neuron migration GO:0021852 1 0.429
negative regulation of cell development GO:0010721 169 0.426
Mouse
paraxial mesodermal cell differentiation GO:0048342 2 0.425
nephron epithelium morphogenesis GO:0072088 68 0.424
t cell activation GO:0042110 289 0.414
male gamete generation GO:0048232 285 0.413
Mouse Fly
appendage development GO:0048736 166 0.408
cell fate specification GO:0001708 72 0.405
mesenchyme development GO:0060485 152 0.399
regulation of cell cycle GO:0051726 281 0.391
Mouse
respiratory system development GO:0060541 190 0.390
Mouse
somitogenesis GO:0001756 69 0.374
ureteric bud morphogenesis GO:0060675 62 0.373
appendage morphogenesis GO:0035107 149 0.367
inner ear morphogenesis GO:0042472 101 0.364
Mouse
auditory receptor cell fate determination GO:0042668 3 0.361
dendrite development GO:0016358 115 0.356
neural crest cell differentiation GO:0014033 54 0.355
regulation of ureteric bud formation GO:0072106 3 0.352
Mouse
nephron epithelium development GO:0072009 92 0.349
ear development GO:0043583 200 0.347
positive regulation of glial cell proliferation GO:0060252 4 0.342
cardiac chamber morphogenesis GO:0003206 93 0.342
tube formation GO:0035148 140 0.332
Mouse
axon guidance GO:0007411 141 0.332
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.328
forebrain neuron differentiation GO:0021879 52 0.322
germ cell development GO:0007281 185 0.322
Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.319
camera type eye development GO:0043010 266 0.319
Mouse
neural tube development GO:0021915 160 0.318
mesonephric tubule morphogenesis GO:0072171 63 0.315
lung development GO:0030324 164 0.307
nephron morphogenesis GO:0072028 69 0.307
hindbrain development GO:0030902 128 0.306
cell adhesion GO:0007155 329 0.305
leukocyte differentiation GO:0002521 342 0.300
neuron migration GO:0001764 122 0.298
regulation of retina development in camera type eye GO:1902866 3 0.297
Mouse
muscle cell differentiation GO:0042692 261 0.296
Mouse
regulation of bmp signaling pathway GO:0030510 60 0.293
regulation of cell adhesion GO:0030155 154 0.292
spermatogenesis GO:0007283 284 0.290
Mouse Fly
digestive tract morphogenesis GO:0048546 147 0.289
axonogenesis GO:0007409 274 0.283
central nervous system neuron development GO:0021954 67 0.283
morphogenesis of a branching structure GO:0001763 203 0.281
forebrain neuron fate commitment GO:0021877 13 0.281
skin development GO:0043588 220 0.277
regulation of chondrocyte differentiation GO:0032330 33 0.277
ear morphogenesis GO:0042471 118 0.277
regulation of stem cell differentiation GO:2000736 50 0.276
Mouse
cerebral cortex neuron differentiation GO:0021895 19 0.275
neural crest cell development GO:0014032 48 0.275
myotube differentiation GO:0014902 105 0.274
Mouse
neural tube closure GO:0001843 90 0.273
ventral spinal cord interneuron fate commitment GO:0060579 14 0.260
nephron development GO:0072006 109 0.260
chondrocyte differentiation GO:0002062 72 0.255
telencephalon development GO:0021537 186 0.255
Mouse
mesoderm morphogenesis GO:0048332 64 0.246
regulation of heart morphogenesis GO:2000826 22 0.246
Mouse
pituitary gland development GO:0021983 38 0.245
Mouse
kidney morphogenesis GO:0060993 83 0.240
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.237
gliogenesis GO:0042063 141 0.227
Fly
trachea cartilage morphogenesis GO:0060535 4 0.226
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.225
regulation of stem cell proliferation GO:0072091 78 0.222
Mouse
heart morphogenesis GO:0003007 178 0.221
Mouse
outflow tract morphogenesis GO:0003151 53 0.218
Mouse
somite development GO:0061053 81 0.217
Mouse
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.216
epithelial cell proliferation GO:0050673 174 0.213
Mouse
regulation of neuron projection development GO:0010975 169 0.212
mesodermal cell fate specification GO:0007501 11 0.211
apoptotic signaling pathway GO:0097190 306 0.210
embryonic heart tube morphogenesis GO:0003143 51 0.209
metanephros development GO:0001656 79 0.208
embryonic eye morphogenesis GO:0048048 29 0.208
Mouse
tongue development GO:0043586 18 0.202
Mouse
extracellular structure organization GO:0043062 148 0.201
ectoderm formation GO:0001705 3 0.200
morphogenesis of a branching epithelium GO:0061138 193 0.200
cell fate specification involved in pattern specification GO:0060573 11 0.200
mesodermal cell differentiation GO:0048333 22 0.199
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.196
limb development GO:0060173 166 0.196
positive regulation of nervous system development GO:0051962 221 0.196
cardiac muscle tissue morphogenesis GO:0055008 44 0.190
glial cell differentiation GO:0010001 131 0.189
skeletal muscle cell differentiation GO:0035914 66 0.188
Mouse
oligodendrocyte differentiation GO:0048709 53 0.185
chemotaxis GO:0006935 247 0.184
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.182
regulation of neuroblast proliferation GO:1902692 27 0.181
Mouse
olfactory bulb development GO:0021772 30 0.181
ventral spinal cord development GO:0021517 48 0.181
embryonic epithelial tube formation GO:0001838 130 0.180
Mouse
cranial nerve morphogenesis GO:0021602 26 0.179
Mouse
nephric duct formation GO:0072179 4 0.179
histone modification GO:0016570 159 0.177
astrocyte fate commitment GO:0060018 4 0.176
regulation of myotube differentiation GO:0010830 62 0.175
pharynx development GO:0060465 1 0.174
ventricular cardiac muscle tissue development GO:0003229 38 0.174
developmental maturation GO:0021700 193 0.171
Mouse
cardiac chamber development GO:0003205 108 0.171
limbic system development GO:0021761 72 0.169
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.169
metanephric nephron morphogenesis GO:0072273 19 0.168
ossification GO:0001503 216 0.167
regulation of homeostatic process GO:0032844 182 0.167
spinal cord association neuron differentiation GO:0021527 14 0.165
kidney development GO:0001822 213 0.165
cardiac epithelial to mesenchymal transition GO:0060317 18 0.162
urogenital system development GO:0001655 261 0.161
bmp signaling pathway GO:0030509 93 0.161
multicellular organismal homeostasis GO:0048871 164 0.161
epithelial tube formation GO:0072175 130 0.160
Mouse
endocrine system development GO:0035270 98 0.159
Mouse Fly
hindbrain morphogenesis GO:0021575 46 0.159
bone morphogenesis GO:0060349 78 0.159
lung cell differentiation GO:0060479 30 0.158
regulation of auditory receptor cell differentiation GO:0045607 4 0.157
primary neural tube formation GO:0014020 95 0.155
myeloid cell differentiation GO:0030099 233 0.154
embryonic heart tube development GO:0035050 65 0.154
alpha beta t cell differentiation GO:0046632 69 0.153
trophectodermal cell differentiation GO:0001829 21 0.151
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.149
epithelial tube morphogenesis GO:0060562 303 0.149
myeloid leukocyte differentiation GO:0002573 119 0.147
positive regulation of ureteric bud formation GO:0072107 3 0.145
Mouse
pallium development GO:0021543 120 0.144
cell fate determination GO:0001709 32 0.144
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.143
regulation of cellular amino acid metabolic process GO:0006521 5 0.143
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.143
lung epithelial cell differentiation GO:0060487 29 0.142
alpha beta t cell activation GO:0046631 91 0.142
regulation of leukocyte differentiation GO:1902105 159 0.141
spermatid differentiation GO:0048515 115 0.141
Mouse
peptidyl amino acid modification GO:0018193 336 0.140
midbrain development GO:0030901 35 0.139
notch signaling pathway GO:0007219 71 0.139
regulation of cellular amine metabolic process GO:0033238 20 0.139
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.138
spinal cord dorsal ventral patterning GO:0021513 23 0.138
metanephric capsule specification GO:0072267 1 0.137
aorta development GO:0035904 23 0.137
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.137
notochord development GO:0030903 20 0.136
forebrain morphogenesis GO:0048853 17 0.135
regulation of transferase activity GO:0051338 263 0.135
metanephric nephron tubule formation GO:0072289 4 0.134
epithelial cell development GO:0002064 159 0.133
segmentation GO:0035282 93 0.133
amine metabolic process GO:0009308 45 0.133
muscle cell development GO:0055001 133 0.132
Mouse
mitral valve development GO:0003174 4 0.132
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.132
cell fate commitment involved in pattern specification GO:0060581 14 0.130
sensory perception of sound GO:0007605 97 0.129
Mouse
epithelial cell fate commitment GO:0072148 13 0.128
somatotropin secreting cell differentiation GO:0060126 4 0.128
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.127
Mouse
somatic stem cell maintenance GO:0035019 47 0.127
cardiocyte differentiation GO:0035051 87 0.127
cell maturation GO:0048469 127 0.126
Mouse
somatic sex determination GO:0018993 2 0.126
cytokine production GO:0001816 319 0.125
cerebral cortex development GO:0021987 86 0.124
primitive streak formation GO:0090009 10 0.124
nephron tubule epithelial cell differentiation GO:0072160 11 0.123
visceral motor neuron differentiation GO:0021524 3 0.123
neuroblast differentiation GO:0014016 2 0.123
Mouse
peripheral nervous system neuron axonogenesis GO:0048936 3 0.123
muscle tissue morphogenesis GO:0060415 53 0.123
blastocyst formation GO:0001825 33 0.123
formation of primary germ layer GO:0001704 77 0.122
b cell activation GO:0042113 161 0.122
renal system development GO:0072001 225 0.122
endodermal cell fate specification GO:0001714 4 0.120
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.120
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.119
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.119
regulation of epithelial cell proliferation GO:0050678 141 0.119
Mouse
hindbrain formation GO:0021576 1 0.118
embryonic placenta development GO:0001892 98 0.118
regulation of glial cell differentiation GO:0045685 41 0.117
metanephric nephron tubule epithelial cell differentiation GO:0072257 5 0.117
regulation of cell cycle process GO:0010564 160 0.117
Mouse
kidney rudiment formation GO:0072003 3 0.117
gastrulation GO:0007369 116 0.116
positive regulation of lymphocyte activation GO:0051251 140 0.115
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.115
embryonic camera type eye development GO:0031076 36 0.115
Mouse
lung epithelium development GO:0060428 37 0.115
mesenchymal cell proliferation GO:0010463 44 0.115
Mouse
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.114
cellular homeostasis GO:0019725 240 0.114
carbon catabolite activation of transcription GO:0045991 4 0.113
central nervous system vasculogenesis GO:0022009 3 0.112
regulation of lymphocyte activation GO:0051249 240 0.112
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.112
Mouse
negative regulation of neuron projection development GO:0010977 50 0.111
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.111
positive regulation of cellular amine metabolic process GO:0033240 5 0.110
pericardium development GO:0060039 16 0.110
response to growth factor GO:0070848 198 0.110
skeletal muscle organ development GO:0060538 163 0.109
Mouse
regulation of gliogenesis GO:0014013 50 0.109
epithelial to mesenchymal transition GO:0001837 47 0.108
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.107
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.107
cerebellum formation GO:0021588 1 0.107
prostate gland stromal morphogenesis GO:0060741 2 0.106
mesodermal cell fate commitment GO:0001710 17 0.105
stem cell proliferation GO:0072089 117 0.105
regulation of system process GO:0044057 200 0.105
single organismal cell cell adhesion GO:0016337 131 0.104
cellular response to retinoic acid GO:0071300 25 0.103
regulation of t cell differentiation GO:0045580 83 0.103
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.103
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.103
jak stat cascade GO:0007259 42 0.101
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.101
regulation of cartilage development GO:0061035 44 0.100
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.100
negative regulation of fat cell differentiation GO:0045599 36 0.099
regulation of kidney development GO:0090183 40 0.099
compound eye development GO:0048749 1 0.099
Fly
ameboidal type cell migration GO:0001667 128 0.098
pancreatic pp cell fate commitment GO:0003329 2 0.098
cell proliferation involved in heart morphogenesis GO:0061323 15 0.098
Mouse
positive regulation of gliogenesis GO:0014015 27 0.097
hair cell differentiation GO:0035315 40 0.096
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.096
pattern specification involved in metanephros development GO:0072268 4 0.096
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.096
tendon cell differentiation GO:0035990 4 0.095
brain morphogenesis GO:0048854 32 0.095
cardiac muscle tissue development GO:0048738 130 0.095
blastocyst development GO:0001824 80 0.095
pancreatic a cell fate commitment GO:0003326 2 0.095
specification of organ position GO:0010159 3 0.094
bone development GO:0060348 120 0.093
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.093
mesoderm formation GO:0001707 62 0.093
body morphogenesis GO:0010171 45 0.093
positive regulation of protein phosphorylation GO:0001934 242 0.092
midbrain hindbrain boundary maturation GO:0021732 1 0.092
syncytium formation by plasma membrane fusion GO:0000768 42 0.091
locomotory behavior GO:0007626 195 0.091
forebrain regionalization GO:0021871 25 0.091
Mouse
regulation of t cell activation GO:0050863 170 0.091
mesenchyme morphogenesis GO:0072132 32 0.090
mesonephros development GO:0001823 97 0.090
neuron fate determination GO:0048664 9 0.090
aortic valve morphogenesis GO:0003180 4 0.090
nephrogenic mesenchyme development GO:0072076 3 0.089
negative regulation of intracellular signal transduction GO:1902532 167 0.089
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.088
embryonic digestive tract morphogenesis GO:0048557 17 0.088
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.088
regulation of organ formation GO:0003156 34 0.087
Mouse
cell differentiation involved in kidney development GO:0061005 33 0.087
carbohydrate homeostasis GO:0033500 128 0.087
optic nerve development GO:0021554 8 0.086
trabecula morphogenesis GO:0061383 40 0.085
mitotic cell cycle GO:0000278 195 0.084
respiratory tube development GO:0030323 167 0.084
negative regulation of cell fate specification GO:0009996 4 0.084
rhombomere development GO:0021546 8 0.084
autonomic nervous system development GO:0048483 43 0.084
Mouse
cochlea morphogenesis GO:0090103 22 0.083
Mouse
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.083
palate development GO:0060021 76 0.083
histone acetylation GO:0016573 41 0.082
ras protein signal transduction GO:0007265 77 0.081
regulation of membrane permeability GO:0090559 18 0.080
nephron tubule formation GO:0072079 20 0.080
Mouse
multicellular organism growth GO:0035264 161 0.080
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.080
lung induction GO:0060492 3 0.079
cell proliferation in hindbrain GO:0021534 10 0.079
positive regulation of transcription by glucose GO:0046016 3 0.079
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.079
renal tubule development GO:0061326 87 0.079
regulation of stem cell maintenance GO:2000036 17 0.078
hypothalamus development GO:0021854 16 0.078
positive regulation of keratinocyte proliferation GO:0010838 4 0.078
mammary gland epithelium development GO:0061180 65 0.078
cardiac ventricle morphogenesis GO:0003208 50 0.078
regulation of epithelial cell differentiation involved in kidney development GO:2000696 10 0.078
cardiac septum morphogenesis GO:0060411 46 0.078
regulation of cellular ketone metabolic process GO:0010565 66 0.078
hypophysis morphogenesis GO:0048850 3 0.078
myeloid cell homeostasis GO:0002262 114 0.077
branching involved in ureteric bud morphogenesis GO:0001658 56 0.077
covalent chromatin modification GO:0016569 163 0.076
aorta morphogenesis GO:0035909 22 0.076
Mouse
regulation of fat cell differentiation GO:0045598 81 0.075
positive regulation of cell cycle GO:0045787 92 0.075
regulation of protein kinase activity GO:0045859 232 0.075
metencephalon development GO:0022037 89 0.074
response to acid chemical GO:0001101 111 0.074
regulation of epithelial to mesenchymal transition GO:0010717 22 0.074
organelle fission GO:0048285 170 0.074
mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072038 7 0.073
paramesonephric duct development GO:0061205 3 0.073
positive regulation of cell death GO:0010942 224 0.073
forebrain cell migration GO:0021885 58 0.072
regulation of apoptotic signaling pathway GO:2001233 197 0.072
regulation of cell migration GO:0030334 219 0.072
positive regulation of leukocyte differentiation GO:1902107 86 0.072
renal vesicle induction GO:0072034 3 0.071
cell migration involved in gastrulation GO:0042074 13 0.071
endocardial cushion morphogenesis GO:0003203 18 0.071
somite rostral caudal axis specification GO:0032525 13 0.070
middle ear morphogenesis GO:0042474 23 0.070
tongue morphogenesis GO:0043587 8 0.069
Mouse
detection of monosaccharide stimulus GO:0034287 1 0.069
microtubule cytoskeleton organization GO:0000226 157 0.069
endothelium development GO:0003158 45 0.069
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.068
olfactory lobe development GO:0021988 32 0.068
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.067
osteoclast differentiation GO:0030316 62 0.067
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.067
peptidyl tyrosine phosphorylation GO:0018108 143 0.067
cardiac ventricle development GO:0003231 83 0.067
metanephric tubule development GO:0072170 18 0.066
positive regulation of stem cell proliferation GO:2000648 59 0.066
Mouse
regulation of neuron migration GO:2001222 22 0.066
paraxial mesoderm development GO:0048339 18 0.066
positive regulation of apoptotic process GO:0043065 217 0.066
protein localization to organelle GO:0033365 185 0.066
negative regulation of gliogenesis GO:0014014 23 0.066
cell differentiation in hindbrain GO:0021533 24 0.065
endoderm formation GO:0001706 20 0.065
regulation of neuron death GO:1901214 134 0.065
Mouse
regulation of cell activation GO:0050865 289 0.065
regulation of cardiac muscle tissue growth GO:0055021 26 0.065
cytoplasmic transport GO:0016482 234 0.065
regulation of muscle tissue development GO:1901861 97 0.065
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.065
mesangial cell differentiation GO:0072007 4 0.065
thymus development GO:0048538 41 0.064
Mouse
regulation of histone modification GO:0031056 56 0.064
retina development in camera type eye GO:0060041 119 0.064
Mouse
positive regulation of myeloid cell differentiation GO:0045639 43 0.064
kidney mesenchyme development GO:0072074 14 0.064
dorsal spinal cord development GO:0021516 20 0.064
lateral motor column neuron migration GO:0097477 3 0.064
atrioventricular valve morphogenesis GO:0003181 13 0.064
negative regulation of cell activation GO:0050866 111 0.064
apoptotic process involved in morphogenesis GO:0060561 25 0.064
positive regulation of t cell differentiation GO:0045582 52 0.063
odontogenesis of dentin containing tooth GO:0042475 66 0.063
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.062
Mouse
glossopharyngeal nerve morphogenesis GO:0021615 4 0.062
pattern specification involved in kidney development GO:0061004 8 0.062
tendon formation GO:0035992 4 0.061
intestinal epithelial cell maturation GO:0060574 2 0.061
embryonic viscerocranium morphogenesis GO:0048703 8 0.061
regulation of cardioblast differentiation GO:0051890 3 0.061
morphogenesis of embryonic epithelium GO:0016331 159 0.060
Mouse
establishment of organ orientation GO:0048561 1 0.060
rhombomere morphogenesis GO:0021593 2 0.060
positive regulation of t cell activation GO:0050870 101 0.060
rhombomere 3 morphogenesis GO:0021658 2 0.060
cell division GO:0051301 120 0.060
protein modification by small protein conjugation GO:0032446 187 0.060
polarity specification of proximal distal axis GO:0010085 2 0.060
auditory receptor cell fate specification GO:0042667 1 0.060
cardiac septum development GO:0003279 59 0.060
regulation of binding GO:0051098 111 0.060
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.059
mesenchymal to epithelial transition GO:0060231 12 0.059
cellular chemical homeostasis GO:0055082 215 0.059
lateral line system development GO:0048925 1 0.059
face morphogenesis GO:0060325 29 0.059
divalent inorganic cation homeostasis GO:0072507 138 0.059
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.058
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.058
cellular response to glucose stimulus GO:0071333 45 0.058
positive regulation of mapk cascade GO:0043410 170 0.058
cellular ketone metabolic process GO:0042180 84 0.057
sperm motility GO:0030317 47 0.057
cellular amine metabolic process GO:0044106 44 0.057
axial mesoderm formation GO:0048320 3 0.057
biomineral tissue development GO:0031214 64 0.056
determination of left right symmetry GO:0007368 80 0.056
cell type specific apoptotic process GO:0097285 268 0.056
Mouse
epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 4 0.056
regulation of astrocyte differentiation GO:0048710 20 0.056
rhombomere formation GO:0021594 1 0.056
syncytium formation GO:0006949 43 0.055
head morphogenesis GO:0060323 34 0.055
dentate gyrus development GO:0021542 14 0.054
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.054
segment specification GO:0007379 15 0.054
neural crest cell migration GO:0001755 32 0.054
vagus nerve development GO:0021564 3 0.054
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.054
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.054
Mouse
forelimb morphogenesis GO:0035136 40 0.053
peripheral nervous system development GO:0007422 53 0.053
positive regulation of neuroblast proliferation GO:0002052 19 0.053
artery development GO:0060840 53 0.053
Mouse
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.053
mitral valve morphogenesis GO:0003183 4 0.053
skin morphogenesis GO:0043589 38 0.053
positive regulation of cell activation GO:0050867 158 0.053
forebrain neuron development GO:0021884 30 0.053
respiratory gaseous exchange GO:0007585 43 0.052
regulation of striated muscle cell differentiation GO:0051153 81 0.052
extraocular skeletal muscle development GO:0002074 2 0.052
t cell differentiation in thymus GO:0033077 77 0.052
sclerotome development GO:0061056 4 0.052
epithelial cell differentiation involved in kidney development GO:0035850 23 0.052
dorsal ventral neural tube patterning GO:0021904 28 0.051
otic vesicle development GO:0071599 14 0.051
Mouse
determination of heart left right asymmetry GO:0061371 48 0.051
nephron tubule development GO:0072080 84 0.051
specification of loop of henle identity GO:0072086 4 0.051
regulation of lymphocyte differentiation GO:0045619 107 0.051
b cell differentiation GO:0030183 78 0.051
gonad development GO:0008406 141 0.051
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.050
mammary gland epithelial cell proliferation GO:0033598 24 0.050
cd4 positive alpha beta t cell activation GO:0035710 45 0.050
circadian rhythm GO:0007623 114 0.050
Mouse Fly
regulation of neural retina development GO:0061074 3 0.050
Mouse
glomerular mesangial cell development GO:0072144 3 0.050
positive regulation of skeletal muscle fiber development GO:0048743 3 0.050
regulation of cardiac chamber formation GO:1901210 1 0.050
renal capsule formation GO:0072129 1 0.049
cardioblast proliferation GO:0003263 8 0.049
Mouse
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9 0.049
mesonephric epithelium development GO:0072163 94 0.049
intrinsic apoptotic signaling pathway GO:0097193 132 0.049
negative regulation of molecular function GO:0044092 258 0.049

Six2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.092
musculoskeletal system disease DOID:17 0 0.092