|
|
regulation of protein deacetylation
|
GO:0090311 |
17 |
0.990
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.972
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.951
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.948
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.929
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
83 |
0.927
|
Mouse |
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
19 |
0.925
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
35 |
0.923
|
|
|
|
protein deacetylation
|
GO:0006476 |
32 |
0.921
|
Mouse |
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.915
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.911
|
Mouse |
|
|
macromolecule deacylation
|
GO:0098732 |
37 |
0.911
|
Mouse |
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.893
|
Mouse |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.893
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.883
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.853
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.851
|
Mouse |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.841
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.839
|
Mouse |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.827
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.826
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.819
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.817
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
49 |
0.815
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.804
|
Human |
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.804
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.801
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.793
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.793
|
|
|
|
regulation of histone deacetylation
|
GO:0031063 |
12 |
0.778
|
Mouse |
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
51 |
0.773
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.770
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
57 |
0.768
|
Mouse |
|
|
response to growth factor
|
GO:0070848 |
198 |
0.767
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.765
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.758
|
|
|
|
negative regulation of dna replication
|
GO:0008156 |
4 |
0.758
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.756
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.746
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.746
|
|
|
|
cellular senescence
|
GO:0090398 |
11 |
0.740
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.735
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.733
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.729
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.728
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.725
|
Mouse |
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
4 |
0.716
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.716
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
42 |
0.711
|
|
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.710
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.707
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
36 |
0.700
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.696
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.694
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.690
|
|
|
|
cellular response to gamma radiation
|
GO:0071480 |
4 |
0.682
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.679
|
|
|
|
dna repair
|
GO:0006281 |
107 |
0.679
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.674
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.672
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.670
|
|
|
|
response to uv
|
GO:0009411 |
44 |
0.667
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.666
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.665
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.659
|
|
|
|
circadian regulation of gene expression
|
GO:0032922 |
48 |
0.657
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.656
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.655
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.649
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.649
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.648
|
|
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
3 |
0.643
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
74 |
0.643
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.623
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.620
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.619
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
39 |
0.617
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.615
|
|
|
|
chromatin modification
|
GO:0016568 |
187 |
0.614
|
Mouse |
|
|
angiogenesis
|
GO:0001525 |
201 |
0.614
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
47 |
0.613
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.607
|
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.607
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.603
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.601
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.599
|
|
|
|
regulation of histone modification
|
GO:0031056 |
56 |
0.597
|
Mouse |
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.593
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.593
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.592
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.591
|
|
|
|
mammary gland morphogenesis
|
GO:0060443 |
54 |
0.576
|
|
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
3 |
0.573
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.572
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.564
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.563
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.563
|
|
|
|
zymogen activation
|
GO:0031638 |
41 |
0.562
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.561
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
57 |
0.553
|
|
|
|
positive regulation of mammary gland involution
|
GO:1903521 |
4 |
0.553
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.553
|
Mouse |
|
|
positive regulation of chromatin modification
|
GO:1903310 |
28 |
0.547
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.544
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
73 |
0.543
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.540
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
43 |
0.538
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.535
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
77 |
0.525
|
|
|
|
histone modification
|
GO:0016570 |
159 |
0.523
|
Mouse |
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.519
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.519
|
Mouse |
|
|
protein maturation
|
GO:0051604 |
176 |
0.518
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.511
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.508
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.508
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.491
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.487
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.480
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.479
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.474
|
|
|
|
regulation of chromatin organization
|
GO:1902275 |
57 |
0.473
|
Mouse |
|
|
regulation of protein maturation
|
GO:1903317 |
96 |
0.472
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.472
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.471
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.465
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
59 |
0.463
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.462
|
|
|
|
dna replication
|
GO:0006260 |
52 |
0.454
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.447
|
|
|
|
cell aging
|
GO:0007569 |
35 |
0.445
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.445
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.437
|
|
|
|
protein deacylation
|
GO:0035601 |
36 |
0.434
|
Mouse |
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.426
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.419
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.417
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
88 |
0.415
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
90 |
0.414
|
Mouse |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.411
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.411
|
|
|
|
regulation of dna replication
|
GO:0006275 |
17 |
0.406
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.404
|
|
|
|
branching morphogenesis of an epithelial tube
|
GO:0048754 |
159 |
0.401
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.401
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
19 |
0.401
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.400
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
27 |
0.399
|
|
|
|
regulation of protein stability
|
GO:0031647 |
52 |
0.399
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.397
|
Mouse |
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.393
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
28 |
0.388
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.387
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.387
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.377
|
|
|
|
negative regulation of translation
|
GO:0017148 |
22 |
0.377
|
|
|
|
regulation of fibroblast proliferation
|
GO:0048145 |
34 |
0.375
|
Mouse |
|
|
negative regulation of protein maturation
|
GO:1903318 |
79 |
0.371
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.370
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.369
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.368
|
|
|
|
regulation of circadian rhythm
|
GO:0042752 |
58 |
0.368
|
|
|
|
response to hypoxia
|
GO:0001666 |
58 |
0.367
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.364
|
|
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.363
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.362
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.359
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
23 |
0.358
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.357
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.355
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
81 |
0.350
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.350
|
|
|
|
regulation of mammary gland involution
|
GO:1903519 |
4 |
0.348
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.345
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
58 |
0.344
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.338
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
3 |
0.336
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.336
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.334
|
Mouse |
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.331
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
127 |
0.331
|
|
|
|
response to gamma radiation
|
GO:0010332 |
22 |
0.328
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.326
|
|
|
|
histone deacetylation
|
GO:0016575 |
26 |
0.324
|
Mouse |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.322
|
|
|
|
positive regulation of apoptotic process involved in morphogenesis
|
GO:1902339 |
4 |
0.315
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.312
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.312
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.311
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.311
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.304
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.303
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.303
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.302
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.301
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.301
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.298
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.298
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
26 |
0.297
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
35 |
0.296
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.293
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.289
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.284
|
|
|
|
mammary gland involution
|
GO:0060056 |
9 |
0.282
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
79 |
0.281
|
|
|
|
endoplasmic reticulum calcium ion homeostasis
|
GO:0032469 |
11 |
0.279
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.278
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
69 |
0.278
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.274
|
|
|
|
cellular response to radiation
|
GO:0071478 |
28 |
0.274
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.274
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.273
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.271
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.266
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
31 |
0.265
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
28 |
0.264
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
24 |
0.264
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.262
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.261
|
|
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.253
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.252
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.250
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
27 |
0.249
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.244
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
44 |
0.240
|
|
|
|
signal transduction involved in cell cycle checkpoint
|
GO:0072395 |
3 |
0.239
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.236
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.236
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.234
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.232
|
|
|
|
negative regulation of vasculature development
|
GO:1901343 |
26 |
0.230
|
|
|
|
fibroblast proliferation
|
GO:0048144 |
35 |
0.225
|
Mouse |
|
|
cytokine production
|
GO:0001816 |
319 |
0.224
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
28 |
0.223
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.223
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.221
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.218
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.218
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
25 |
0.217
|
|
|
|
cellular response to interleukin 4
|
GO:0071353 |
21 |
0.216
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
48 |
0.215
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.215
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
47 |
0.215
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.214
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.214
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.207
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.207
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.203
|
|
|
|
positive regulation of protein deacetylation
|
GO:0090312 |
9 |
0.202
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.199
|
|
|
|
regulation of protein processing
|
GO:0070613 |
96 |
0.198
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
31 |
0.198
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
68 |
0.196
|
|
|
|
regulation of cell growth
|
GO:0001558 |
91 |
0.195
|
|
|
|
negative regulation of blood vessel morphogenesis
|
GO:2000181 |
25 |
0.195
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.194
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.194
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.194
|
|
|
|
negative regulation of angiogenesis
|
GO:0016525 |
25 |
0.193
|
|
|
|
cellular response to light stimulus
|
GO:0071482 |
19 |
0.193
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
69 |
0.191
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.190
|
Human |
|
|
digestive tract development
|
GO:0048565 |
190 |
0.188
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.184
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.184
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
0.182
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.180
|
Mouse |
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.176
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.175
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.175
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.175
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.173
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.172
|
|
|
|
wound healing
|
GO:0042060 |
157 |
0.170
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
74 |
0.170
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.170
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.169
|
Mouse |
|
|
regulation of ion homeostasis
|
GO:2000021 |
64 |
0.168
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.166
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
20 |
0.165
|
|
|
|
signal transduction involved in mitotic cell cycle checkpoint
|
GO:0072413 |
3 |
0.164
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
70 |
0.164
|
|
|
|
maintenance of protein location in nucleus
|
GO:0051457 |
2 |
0.163
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.162
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
3 |
0.162
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.161
|
|
|
|
response to interleukin 4
|
GO:0070670 |
23 |
0.158
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
15 |
0.157
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
48 |
0.157
|
|
|
|
oocyte differentiation
|
GO:0009994 |
35 |
0.156
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.156
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.155
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.154
|
|
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
22 |
0.153
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.150
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.150
|
Human |
|
|
gliogenesis
|
GO:0042063 |
141 |
0.149
|
Mouse |
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.148
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
122 |
0.146
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.145
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
22 |
0.145
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.145
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
25 |
0.144
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.143
|
|
|
|
cell death in response to oxidative stress
|
GO:0036473 |
24 |
0.142
|
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.141
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.141
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.139
|
|
|
|
negative regulation of synaptic vesicle transport
|
GO:1902804 |
3 |
0.139
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.138
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.138
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.138
|
Human |
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.137
|
|
|
|
regulation of fat cell differentiation
|
GO:0045598 |
81 |
0.135
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.134
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.134
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.134
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.133
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.133
|
|
|
|
signal transduction involved in mitotic dna integrity checkpoint
|
GO:1902403 |
3 |
0.133
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
40 |
0.132
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.131
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.130
|
|
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
3 |
0.130
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.129
|
|
|
|
positive regulation of histone deacetylation
|
GO:0031065 |
7 |
0.129
|
|
|
|
muscle cell development
|
GO:0055001 |
133 |
0.129
|
Mouse |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.128
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.128
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
37 |
0.127
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.125
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.125
|
|
|
|
mammary gland duct morphogenesis
|
GO:0060603 |
38 |
0.125
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.125
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.125
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.123
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.122
|
|
|
|
regulation of b cell apoptotic process
|
GO:0002902 |
13 |
0.121
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.121
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.119
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.119
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.119
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.119
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.119
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.118
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.118
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.116
|
Mouse |
|
|
rap protein signal transduction
|
GO:0032486 |
3 |
0.114
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.113
|
|
|
|
striated muscle cell development
|
GO:0055002 |
125 |
0.113
|
Mouse |
|
|
regulation of hormone levels
|
GO:0010817 |
211 |
0.113
|
|
|
|
dna biosynthetic process
|
GO:0071897 |
22 |
0.113
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.112
|
|
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
0.111
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
14 |
0.111
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.111
|
Human |
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
9 |
0.111
|
|
|
|
telencephalon development
|
GO:0021537 |
186 |
0.110
|
Mouse |
|
|
regulation of dna templated transcription in response to stress
|
GO:0043620 |
9 |
0.110
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.109
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.109
|
|
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.108
|
|
|
|
oocyte development
|
GO:0048599 |
33 |
0.107
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
31 |
0.106
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.104
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.104
|
|
|
|
telomere maintenance via telomerase
|
GO:0007004 |
1 |
0.104
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.104
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
41 |
0.103
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.103
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.103
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
15 |
0.101
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.100
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
36 |
0.100
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.100
|
|
|
|
apoptotic process involved in development
|
GO:1902742 |
28 |
0.099
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
95 |
0.099
|
Human |
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.099
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
83 |
0.098
|
|
|
|
appendage morphogenesis
|
GO:0035107 |
149 |
0.098
|
Mouse |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.097
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.097
|
|
|
|
cellular response to drug
|
GO:0035690 |
15 |
0.097
|
|
|
|
regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0043618 |
8 |
0.097
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
45 |
0.096
|
|
|
|
respiratory tube development
|
GO:0030323 |
167 |
0.096
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.096
|
|
|
|
negative regulation of synaptic vesicle exocytosis
|
GO:2000301 |
3 |
0.095
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.095
|
|
|
|
negative regulation of ossification
|
GO:0030279 |
49 |
0.094
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
83 |
0.093
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.093
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.093
|
|
|
|
regulation of ovulation
|
GO:0060278 |
3 |
0.093
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.092
|
|
|
|
viral process
|
GO:0016032 |
41 |
0.092
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.092
|
|
|
|
response to osmotic stress
|
GO:0006970 |
21 |
0.092
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
71 |
0.091
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.091
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
56 |
0.090
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.089
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.089
|
|
|
|
rna dependent dna replication
|
GO:0006278 |
3 |
0.089
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.088
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.088
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.088
|
|
|
|
oocyte construction
|
GO:0007308 |
2 |
0.087
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.086
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.086
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
34 |
0.086
|
|
|
|
regulation of cell cycle arrest
|
GO:0071156 |
12 |
0.086
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.085
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.085
|
|
|
|
nucleus organization
|
GO:0006997 |
45 |
0.084
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.084
|
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.083
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.083
|
Mouse |
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.083
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.083
|
Human |
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
34 |
0.083
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.083
|
|
|
|
branching involved in mammary gland duct morphogenesis
|
GO:0060444 |
27 |
0.082
|
|
|
|
organelle fission
|
GO:0048285 |
170 |
0.082
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.082
|
|
|
|
translation
|
GO:0006412 |
93 |
0.082
|
|
|
|
positive regulation of leukocyte apoptotic process
|
GO:2000108 |
21 |
0.082
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.082
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.082
|
|
|
|
positive regulation of lymphocyte apoptotic process
|
GO:0070230 |
13 |
0.081
|
|
|
|
meiotic cell cycle process
|
GO:1903046 |
77 |
0.081
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.081
|
|
|
|
viral life cycle
|
GO:0019058 |
36 |
0.081
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
77 |
0.080
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.080
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.080
|
Mouse |
|
|
hindbrain development
|
GO:0030902 |
128 |
0.080
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.080
|
Mouse |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.080
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.079
|
Human |
|
|
regulation of clathrin mediated endocytosis
|
GO:2000369 |
4 |
0.079
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
0.079
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.079
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.078
|
|
|
|
telomere maintenance
|
GO:0000723 |
19 |
0.078
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.078
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.078
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.077
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.077
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
45 |
0.076
|
|
|
|
mitochondrial membrane organization
|
GO:0007006 |
26 |
0.076
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.076
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
115 |
0.076
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.076
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.075
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.075
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.075
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.075
|
|
|
|
regulation of translation
|
GO:0006417 |
71 |
0.075
|
|
|
|
pallium development
|
GO:0021543 |
120 |
0.075
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
143 |
0.074
|
|
|
|
regulation of ossification
|
GO:0030278 |
112 |
0.073
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.073
|
|
|
|
sphingolipid metabolic process
|
GO:0006665 |
45 |
0.073
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.073
|
|
|
|
regulation of tissue remodeling
|
GO:0034103 |
38 |
0.073
|
|
|
|
skeletal muscle organ development
|
GO:0060538 |
163 |
0.073
|
Human Mouse |
|
|
thymus development
|
GO:0048538 |
41 |
0.073
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.073
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.073
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
93 |
0.072
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.072
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.072
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.071
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.071
|
Mouse |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.070
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
138 |
0.069
|
|
|
|
apoptotic process involved in mammary gland involution
|
GO:0060057 |
4 |
0.069
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.068
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.068
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.068
|
Human Mouse |
|
|
oocyte axis specification
|
GO:0007309 |
2 |
0.068
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
24 |
0.067
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.067
|
|
|
|
oxidation reduction process
|
GO:0055114 |
342 |
0.066
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.066
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.066
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.066
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.066
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.066
|
|
