Mus musculus

118 known processes

Slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

(Aliases: DMT1,Nramp2,van,mk,DCT1)

Slc11a2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cofactor metabolic process GO:0051186 80 0.926
erythrocyte differentiation GO:0030218 88 0.879
transition metal ion transport GO:0000041 38 0.797
homeostasis of number of cells GO:0048872 210 0.778
cation homeostasis GO:0055080 212 0.728
folic acid containing compound metabolic process GO:0006760 3 0.694
transition metal ion homeostasis GO:0055076 54 0.685
myeloid cell differentiation GO:0030099 233 0.504
metal ion homeostasis GO:0055065 189 0.502
iron ion homeostasis GO:0055072 36 0.438
cellular ion homeostasis GO:0006873 165 0.433
Mouse
cellular amino acid metabolic process GO:0006520 103 0.404
myeloid cell homeostasis GO:0002262 114 0.373
inorganic ion transmembrane transport GO:0098660 234 0.357
tetrapyrrole biosynthetic process GO:0033014 16 0.344
cofactor biosynthetic process GO:0051188 41 0.295
porphyrin containing compound metabolic process GO:0006778 22 0.258
tetrapyrrole metabolic process GO:0033013 22 0.254
cellular transition metal ion homeostasis GO:0046916 32 0.219
Mouse
regulation of translational initiation in response to stress GO:0043558 5 0.209
porphyrin containing compound biosynthetic process GO:0006779 16 0.204
cellular metal ion homeostasis GO:0006875 151 0.198
Mouse
cation transport GO:0006812 399 0.197
myeloid leukocyte differentiation GO:0002573 119 0.182
pteridine containing compound metabolic process GO:0042558 5 0.179
cellular iron ion homeostasis GO:0006879 16 0.177
Mouse
glutathione metabolic process GO:0006749 16 0.150
embryonic hemopoiesis GO:0035162 23 0.150
protein localization to plasma membrane GO:0072659 57 0.144
response to iron ion GO:0010039 4 0.143
Human
transmembrane transport GO:0055085 412 0.141
cellular homeostasis GO:0019725 240 0.137
Mouse
oxidation reduction process GO:0055114 342 0.133
lymphocyte proliferation GO:0046651 164 0.129
Mouse
iron ion transport GO:0006826 17 0.128
response to starvation GO:0042594 65 0.126
erythrocyte maturation GO:0043249 6 0.114
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.113
amine metabolic process GO:0009308 45 0.104
organonitrogen compound biosynthetic process GO:1901566 192 0.097
regulation of cellular ketone metabolic process GO:0010565 66 0.095
regulation of transcription from rna polymerase ii promoter in response to iron GO:0034395 3 0.087
positive regulation of potassium ion transmembrane transporter activity GO:1901018 1 0.084
regulation of cellular amino acid metabolic process GO:0006521 5 0.083
protein localization to membrane GO:0072657 108 0.082
cellular modified amino acid metabolic process GO:0006575 63 0.081
membrane organization GO:0061024 245 0.078
multicellular organism growth GO:0035264 161 0.078
cellular ketone metabolic process GO:0042180 84 0.075
t cell activation GO:0042110 289 0.074
Mouse
response to extracellular stimulus GO:0009991 127 0.074
fertilization GO:0009566 127 0.073
ion transmembrane transport GO:0034220 361 0.072
t cell proliferation GO:0042098 120 0.069
Mouse
circulatory system process GO:0003013 197 0.067
lipid homeostasis GO:0055088 63 0.067
polysaccharide metabolic process GO:0005976 39 0.067
alpha amino acid metabolic process GO:1901605 59 0.066
copper ion transport GO:0006825 10 0.065
Human
carbohydrate transport GO:0008643 62 0.063
trivalent inorganic cation transport GO:0072512 5 0.063
endomembrane system organization GO:0010256 147 0.061
cell maturation GO:0048469 127 0.061
immune effector process GO:0002252 321 0.060
Mouse
wound healing GO:0042060 157 0.060
Mouse
cellular response to nutrient levels GO:0031669 64 0.058
protein localization to organelle GO:0033365 185 0.058
Mouse
leukocyte differentiation GO:0002521 342 0.058
coenzyme metabolic process GO:0006732 52 0.057
osteoclast differentiation GO:0030316 62 0.056
hindbrain development GO:0030902 128 0.055
reactive oxygen species biosynthetic process GO:1903409 8 0.055
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.055
axon guidance GO:0007411 141 0.053
protein targeting to membrane GO:0006612 20 0.053
body morphogenesis GO:0010171 45 0.052
cerebellar purkinje cell layer development GO:0021680 26 0.051
multicellular organismal homeostasis GO:0048871 164 0.051
nitrogen compound transport GO:0071705 271 0.050
Mouse
multicellular organismal signaling GO:0035637 91 0.049
cell activation involved in immune response GO:0002263 126 0.047
Mouse
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 12 0.047
small gtpase mediated signal transduction GO:0007264 97 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
regulation of tissue remodeling GO:0034103 38 0.045
regulation of intracellular ph GO:0051453 11 0.044
Mouse
neuron projection guidance GO:0097485 141 0.044
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.043
negative regulation of heart rate GO:0010459 4 0.043
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.043
hemoglobin metabolic process GO:0020027 13 0.042
regulation of protein binding GO:0043393 60 0.042
sensory perception GO:0007600 245 0.042
transmission of nerve impulse GO:0019226 76 0.041
lymphocyte homeostasis GO:0002260 64 0.041
peptidyl amino acid modification GO:0018193 336 0.041
positive regulation of bone resorption GO:0045780 13 0.040
cellular chemical homeostasis GO:0055082 215 0.040
Mouse
male gamete generation GO:0048232 285 0.039
cellular response to dna damage stimulus GO:0006974 207 0.039
trabecula formation GO:0060343 24 0.039
cellular carbohydrate metabolic process GO:0044262 119 0.038
sensory perception of mechanical stimulus GO:0050954 107 0.038
regulation of lymphocyte activation GO:0051249 240 0.037
cellular amine metabolic process GO:0044106 44 0.037
bone remodeling GO:0046849 53 0.037
heart process GO:0003015 94 0.037
spermatogenesis GO:0007283 284 0.037
monosaccharide metabolic process GO:0005996 106 0.036
developmental maturation GO:0021700 193 0.036
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.036
action potential GO:0001508 78 0.036
reactive nitrogen species metabolic process GO:2001057 0 0.035
urogenital system development GO:0001655 261 0.035
trabecula morphogenesis GO:0061383 40 0.034
t cell mediated immunity GO:0002456 50 0.034
Mouse
fibrinolysis GO:0042730 3 0.034
axon ensheathment GO:0008366 76 0.034
tissue remodeling GO:0048771 102 0.034
protein localization to juxtaparanode region of axon GO:0071205 4 0.033
response to light stimulus GO:0009416 135 0.033
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.033
regulation of carbohydrate biosynthetic process GO:0043255 40 0.033
peroxisome organization GO:0007031 7 0.033
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.033
Mouse
positive regulation of potassium ion transport GO:0043268 3 0.033
inflammatory response GO:0006954 244 0.032
Mouse
sequestering of metal ion GO:0051238 19 0.032
positive regulation of bone remodeling GO:0046852 13 0.032
regulation of cellular amine metabolic process GO:0033238 20 0.032
cellular response to lipopolysaccharide GO:0071222 77 0.032
leukocyte activation involved in immune response GO:0002366 126 0.031
Mouse
cellular polysaccharide metabolic process GO:0044264 38 0.031
regulation of ion transport GO:0043269 215 0.031
regulation of response to dna damage stimulus GO:2001020 34 0.030
sterol homeostasis GO:0055092 45 0.030
regulation of sodium ion transport GO:0002028 29 0.030
protein heterooligomerization GO:0051291 14 0.030
chemotaxis GO:0006935 247 0.029
establishment of glial blood brain barrier GO:0060857 2 0.029
nucleocytoplasmic transport GO:0006913 139 0.029
Mouse
tissue homeostasis GO:0001894 115 0.028
anatomical structure homeostasis GO:0060249 145 0.028
positive regulation of homeostatic process GO:0032846 64 0.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.028
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.028
regulation of cytokine production GO:0001817 266 0.026
Mouse
translation GO:0006412 93 0.026
glucose 6 phosphate metabolic process GO:0051156 8 0.026
adaptive immune response GO:0002250 155 0.026
Mouse
multicellular organismal iron ion homeostasis GO:0060586 8 0.025
regulation of homeostatic process GO:0032844 182 0.025
common partner smad protein phosphorylation GO:0007182 2 0.025
cellular lipid metabolic process GO:0044255 323 0.025
cellular divalent inorganic cation homeostasis GO:0072503 127 0.025
nuclear division GO:0000280 158 0.025
primary neural tube formation GO:0014020 95 0.024
plasma membrane organization GO:0007009 90 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
Mouse
cellular response to extracellular stimulus GO:0031668 81 0.024
regulation of reactive oxygen species metabolic process GO:2000377 40 0.024
cellular response to erythropoietin GO:0036018 1 0.024
regulation of leukocyte mediated immunity GO:0002703 104 0.023
dephosphorylation GO:0016311 129 0.023
bone resorption GO:0045453 38 0.023
protein import GO:0017038 101 0.023
Mouse
cellular amide metabolic process GO:0043603 58 0.023
bmp signaling pathway GO:0030509 93 0.023
digestive tract development GO:0048565 190 0.022
axonogenesis GO:0007409 274 0.022
cytokine mediated signaling pathway GO:0019221 115 0.022
regulation of membrane potential GO:0042391 192 0.022
alcohol metabolic process GO:0006066 116 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.022
intrinsic apoptotic signaling pathway GO:0097193 132 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
heart contraction GO:0060047 93 0.021
iron ion import into cell GO:0097459 4 0.021
spleen development GO:0048536 39 0.020
translational initiation GO:0006413 24 0.020
neural tube closure GO:0001843 90 0.020
cholesterol homeostasis GO:0042632 44 0.020
leukocyte proliferation GO:0070661 172 0.020
Mouse
regulation of hormone levels GO:0010817 211 0.020
ras protein signal transduction GO:0007265 77 0.020
coagulation GO:0050817 78 0.020
regulation of cell activation GO:0050865 289 0.020
hemostasis GO:0007599 78 0.020
regulation of bmp signaling pathway GO:0030510 60 0.020
positive regulation of immune effector process GO:0002699 107 0.020
cell fate commitment GO:0045165 210 0.020
visual perception GO:0007601 52 0.020
erythropoietin mediated signaling pathway GO:0038162 1 0.019
photoreceptor cell differentiation GO:0046530 52 0.019
cation transmembrane transport GO:0098655 266 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
production of molecular mediator of immune response GO:0002440 103 0.019
Mouse
regulation of cellular response to stress GO:0080135 159 0.019
b cell differentiation GO:0030183 78 0.019
regulation of t cell activation GO:0050863 170 0.019
hormone metabolic process GO:0042445 86 0.019
eye photoreceptor cell differentiation GO:0001754 41 0.019
cell cell junction assembly GO:0007043 27 0.019
glucan metabolic process GO:0044042 32 0.018
positive regulation of potassium ion transmembrane transport GO:1901381 3 0.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.018
amino acid transport GO:0006865 61 0.018
Mouse
sensory perception of sound GO:0007605 97 0.018
regulation of protein stability GO:0031647 52 0.018
cellular response to inorganic substance GO:0071241 37 0.018
regulation of leukocyte differentiation GO:1902105 159 0.017
cellular component assembly involved in morphogenesis GO:0010927 139 0.017
response to erythropoietin GO:0036017 1 0.017
actin mediated cell contraction GO:0070252 15 0.017
establishment of protein localization to plasma membrane GO:0090002 34 0.017
glucose transport GO:0015758 56 0.017
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.017
regulation of metal ion transport GO:0010959 106 0.017
divalent inorganic cation transport GO:0072511 178 0.017
nuclear transport GO:0051169 139 0.017
Mouse
metencephalon development GO:0022037 89 0.016
tube formation GO:0035148 140 0.016
lipid storage GO:0019915 36 0.016
release of sequestered calcium ion into cytosol GO:0051209 42 0.016
positive regulation of insulin secretion GO:0032024 26 0.016
sodium ion transport GO:0006814 73 0.016
positive regulation of calcium ion transport GO:0051928 27 0.016
protein modification by small protein conjugation or removal GO:0070647 207 0.016
positive regulation of leukocyte proliferation GO:0070665 73 0.016
positive regulation of cell killing GO:0031343 33 0.015
protein localization to nucleus GO:0034504 121 0.015
Mouse
apoptotic signaling pathway GO:0097190 306 0.015
calcium ion transport GO:0006816 159 0.015
hexose transport GO:0008645 56 0.015
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.015
regulation of vesicle mediated transport GO:0060627 139 0.015
Mouse
iron ion import GO:0097286 5 0.015
zymogen activation GO:0031638 41 0.015
Human
cellular response to thyroid hormone stimulus GO:0097067 1 0.015
cell cell junction organization GO:0045216 72 0.015
compound eye development GO:0048749 1 0.015
positive regulation of protein binding GO:0032092 29 0.015
regulation of bone remodeling GO:0046850 28 0.015
regulation of cell killing GO:0031341 40 0.015
organic anion transport GO:0015711 137 0.015
Mouse
protein modification by small protein conjugation GO:0032446 187 0.014
epithelial cell development GO:0002064 159 0.014
gland development GO:0048732 330 0.014
learning or memory GO:0007611 148 0.014
cytosolic calcium ion homeostasis GO:0051480 70 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
mitotic cell cycle process GO:1903047 159 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
positive regulation of cell activation GO:0050867 158 0.014
rho protein signal transduction GO:0007266 32 0.014
response to copper ion GO:0046688 3 0.014
central nervous system neuron differentiation GO:0021953 162 0.014
response to radiation GO:0009314 165 0.014
cytoplasmic transport GO:0016482 234 0.014
Mouse
hexose metabolic process GO:0019318 98 0.014
sequestering of calcium ion GO:0051208 18 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.014
sulfur compound metabolic process GO:0006790 100 0.014
hydrogen ion transmembrane transport GO:1902600 25 0.014
regulation of peptide transport GO:0090087 91 0.014
protein targeting GO:0006605 143 0.014
Mouse
respiratory system development GO:0060541 190 0.013
cytokine production GO:0001816 319 0.013
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.013
intracellular protein transport GO:0006886 204 0.013
Mouse
digestive system development GO:0055123 200 0.013
neural tube formation GO:0001841 108 0.013
glucan biosynthetic process GO:0009250 14 0.013
neuronal action potential GO:0019228 54 0.013
regulation of ph GO:0006885 26 0.013
Mouse
cellular response to external stimulus GO:0071496 88 0.013
organic acid transport GO:0015849 101 0.013
Mouse
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.013
potassium ion transmembrane transport GO:0071805 43 0.013
oxidoreduction coenzyme metabolic process GO:0006733 16 0.013
nuclear import GO:0051170 95 0.013
Mouse
regulation of t cell mediated immunity GO:0002709 34 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
lymphocyte differentiation GO:0030098 242 0.013
regulation of transmembrane transport GO:0034762 128 0.013
regulation of cardiac muscle cell membrane potential GO:0086036 3 0.013
lung development GO:0030324 164 0.013
response to nutrient levels GO:0031667 109 0.013
positive regulation of defense response GO:0031349 124 0.013
regulation of antimicrobial humoral response GO:0002759 3 0.013
blood circulation GO:0008015 195 0.013
antigen processing and presentation of exogenous antigen GO:0019884 26 0.013
cellular polysaccharide biosynthetic process GO:0033692 19 0.013
endothelium development GO:0003158 45 0.012
lymphocyte activation involved in immune response GO:0002285 93 0.012
Mouse
vitamin transmembrane transport GO:0035461 4 0.012
striated muscle adaptation GO:0014888 26 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
Mouse
purine containing compound metabolic process GO:0072521 311 0.012
regulation of defense response GO:0031347 233 0.012
myelination GO:0042552 74 0.012
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.012
positive regulation of hormone secretion GO:0046887 38 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
cell adhesion GO:0007155 329 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.012
glucose metabolic process GO:0006006 92 0.012
progesterone metabolic process GO:0042448 4 0.012
positive regulation of growth GO:0045927 104 0.012
metanephric glomerular mesangium development GO:0072223 3 0.012
cellular response to starvation GO:0009267 57 0.012
divalent metal ion transport GO:0070838 172 0.012
hormone secretion GO:0046879 128 0.012
leukocyte mediated cytotoxicity GO:0001909 62 0.012
hemoglobin biosynthetic process GO:0042541 7 0.012
regulation of bone resorption GO:0045124 24 0.012
macromolecule catabolic process GO:0009057 281 0.012
stem cell differentiation GO:0048863 268 0.012
regulation of translational initiation GO:0006446 15 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
Mouse
regulation of cell cycle GO:0051726 281 0.012
response to glycoside GO:1903416 2 0.011
endocytosis GO:0006897 168 0.011
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.011
positive regulation of cell cycle GO:0045787 92 0.011
glycerolipid metabolic process GO:0046486 122 0.011
oocyte axis specification GO:0007309 2 0.011
protein processing GO:0016485 163 0.011
Human
response to interleukin 15 GO:0070672 3 0.011
cellular protein complex assembly GO:0043623 116 0.011
myosin filament organization GO:0031033 3 0.011
regulation of peptide hormone secretion GO:0090276 75 0.011
carbohydrate biosynthetic process GO:0016051 74 0.011
cellular response to lipid GO:0071396 145 0.011
organophosphate catabolic process GO:0046434 232 0.011
potassium ion transport GO:0006813 52 0.011
regulation of binding GO:0051098 111 0.011
inorganic cation import into cell GO:0098659 4 0.011
monosaccharide biosynthetic process GO:0046364 44 0.011
regulation of apoptotic signaling pathway GO:2001233 197 0.011
mitotic cell cycle GO:0000278 195 0.011
anion transmembrane transport GO:0098656 71 0.011
positive regulation of t cell activation GO:0050870 101 0.011
central nervous system neuron development GO:0021954 67 0.011
regulation of innate immune response GO:0045088 91 0.011
mitotic nuclear division GO:0007067 48 0.011
membrane lipid metabolic process GO:0006643 53 0.011
exocytosis GO:0006887 121 0.011
peptide hormone secretion GO:0030072 109 0.011
cellular response to x ray GO:0071481 2 0.011
protein catabolic process GO:0030163 221 0.011
kit signaling pathway GO:0038109 3 0.011
regulation of heart contraction GO:0008016 77 0.011
metanephric glomerular capillary formation GO:0072277 3 0.011
regulation of b cell differentiation GO:0045577 23 0.011
cellularization GO:0007349 1 0.011
erk1 and erk2 cascade GO:0070371 77 0.011
regulation of cell shape GO:0008360 39 0.011
monosaccharide transport GO:0015749 58 0.010
synapse organization GO:0050808 125 0.010
gastrulation GO:0007369 116 0.010
regulation of t cell differentiation GO:0045580 83 0.010
leukocyte mediated immunity GO:0002443 174 0.010
Mouse
apical constriction GO:0003383 4 0.010
polysaccharide biosynthetic process GO:0000271 20 0.010
pyridine containing compound metabolic process GO:0072524 14 0.010
oocyte construction GO:0007308 2 0.010
membrane lipid biosynthetic process GO:0046467 32 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
natural killer cell mediated cytotoxicity GO:0042267 29 0.010
insulin secretion GO:0030073 89 0.010
nucleotide metabolic process GO:0009117 332 0.010
regulation of secretion GO:0051046 274 0.010
muscle cell differentiation GO:0042692 261 0.010
extracellular matrix organization GO:0030198 147 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
striated muscle myosin thick filament assembly GO:0071688 1 0.010

Slc11a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.765
Human
disease of anatomical entity DOID:7 0 0.765
Human
anemia DOID:2355 0 0.765
Human
hematopoietic system disease DOID:74 0 0.765
Human
disease of metabolism DOID:0014667 0 0.146
inherited metabolic disorder DOID:655 0 0.146
metal metabolism disorder DOID:896 0 0.146
hemolytic anemia DOID:583 0 0.122
normocytic anemia DOID:720 0 0.122
nervous system disease DOID:863 0 0.027
central nervous system disease DOID:331 0 0.024
immune system cancer DOID:0060083 0 0.017
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
hematologic cancer DOID:2531 0 0.012