Mus musculus

234 known processes

Smad2

MAD homolog 2 (Drosophila)

(Aliases: Madh2,Madr2)

Smad2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
metanephric mesenchyme morphogenesis GO:0072133 4 0.991
Mouse
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.975
Mouse
regulation of smad protein import into nucleus GO:0060390 3 0.971
Mouse
gastrulation GO:0007369 116 0.949
regionalization GO:0003002 337 0.947
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.944
Worm
digestive tract development GO:0048565 190 0.911
digestive system development GO:0055123 200 0.907
nephrogenic mesenchyme development GO:0072076 3 0.906
Mouse
germ line stem cell division GO:0042078 2 0.870
response to growth factor GO:0070848 198 0.850
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.846
Mouse
embryonic skeletal system development GO:0048706 120 0.836
regulation of neuron differentiation GO:0045664 281 0.830
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.791
Mouse
erythrocyte differentiation GO:0030218 88 0.786
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.784
cellular response to growth factor stimulus GO:0071363 197 0.783
kidney mesenchyme morphogenesis GO:0072131 4 0.772
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.771
connective tissue development GO:0061448 179 0.750
Mouse
amine metabolic process GO:0009308 45 0.733
digestive tract morphogenesis GO:0048546 147 0.724
skeletal system development GO:0001501 356 0.713
osteoblast fate commitment GO:0002051 4 0.713
Mouse
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.690
positive regulation of protein modification process GO:0031401 299 0.671
Mouse
endothelial cell activation GO:0042118 1 0.665
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.664
Mouse
cell fate commitment GO:0045165 210 0.663
regulation of mapk cascade GO:0043408 248 0.655
central nervous system neuron differentiation GO:0021953 162 0.649
urogenital system development GO:0001655 261 0.637
positive regulation of osteoblast differentiation GO:0045669 34 0.610
Mouse
positive regulation of nervous system development GO:0051962 221 0.582
homeostasis of number of cells GO:0048872 210 0.567
Mouse
brainstem development GO:0003360 3 0.565
Mouse
dendrite development GO:0016358 115 0.560
regulation of osteoblast differentiation GO:0045667 67 0.551
Mouse
cartilage development GO:0051216 140 0.539
Mouse
blood vessel morphogenesis GO:0048514 285 0.534
Mouse
protein localization to nucleus GO:0034504 121 0.521
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.515
pathway restricted smad protein phosphorylation GO:0060389 10 0.514
Mouse
protein import into nucleus GO:0006606 95 0.514
Mouse
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.513
Worm
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.508
Mouse
regulation of cell cycle GO:0051726 281 0.494
Worm
mapk cascade GO:0000165 281 0.478
Mouse
regulation of neuron projection development GO:0010975 169 0.473
epithelial tube morphogenesis GO:0060562 303 0.462
Mouse
germ cell development GO:0007281 185 0.462
Zebrafish Mouse
myeloid cell differentiation GO:0030099 233 0.450
Mouse
negative regulation of cell proliferation GO:0008285 296 0.444
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.439
cell proliferation involved in heart valve development GO:2000793 2 0.429
Mouse
regulation of cell projection organization GO:0031344 206 0.425
oocyte axis specification GO:0007309 2 0.420
positive regulation of cell development GO:0010720 237 0.415
regulation of ossification GO:0030278 112 0.404
Mouse
stem cell differentiation GO:0048863 268 0.399
cell cycle switching GO:0060184 1 0.399
Worm
spermatogenesis GO:0007283 284 0.395
mesendoderm development GO:0048382 3 0.395
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.391
Mouse
cellular amine metabolic process GO:0044106 44 0.390
stem cell division GO:0017145 30 0.385
regulation of transforming growth factor beta2 production GO:0032909 2 0.380
negative regulation of osteoblast proliferation GO:0033689 4 0.380
Mouse
dna metabolic process GO:0006259 303 0.374
negative regulation of phosphorylation GO:0042326 166 0.373
Mouse
regulation of transferase activity GO:0051338 263 0.363
smad protein complex assembly GO:0007183 1 0.361
Human
hindbrain development GO:0030902 128 0.358
Mouse
gastrulation with mouth forming second GO:0001702 29 0.358
Mouse
regulation of cell proliferation involved in heart valve morphogenesis GO:0003250 1 0.358
Mouse
axonogenesis GO:0007409 274 0.357
Mouse
cellular response to dna damage stimulus GO:0006974 207 0.355
epithelial cell proliferation GO:0050673 174 0.353
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.351
positive regulation of cellular protein catabolic process GO:1903364 34 0.349
regulation of protein import into nucleus GO:0042306 52 0.343
Mouse
cellular amino acid metabolic process GO:0006520 103 0.343
camera type eye development GO:0043010 266 0.339
Mouse
smad protein signal transduction GO:0060395 21 0.328
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.325
developmental maturation GO:0021700 193 0.324
oocyte construction GO:0007308 2 0.322
positive regulation of protein ubiquitination GO:0031398 27 0.320
positive regulation of protein localization to nucleus GO:1900182 30 0.320
Mouse
ossification GO:0001503 216 0.317
Mouse
respiratory system development GO:0060541 190 0.316
cell cell junction organization GO:0045216 72 0.308
regulation of myeloid cell differentiation GO:0045637 96 0.307
regulation of protein kinase activity GO:0045859 232 0.303
mesenchymal cell differentiation GO:0048762 107 0.301
developmental cell growth GO:0048588 84 0.298
lens development in camera type eye GO:0002088 62 0.296
Mouse
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.296
Mouse
determination of left right symmetry GO:0007368 80 0.295
Human Mouse
genetic imprinting GO:0071514 27 0.294
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.287
Human Mouse
establishment of protein localization to organelle GO:0072594 118 0.287
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.286
female gamete generation GO:0007292 74 0.285
Zebrafish
skeletal system morphogenesis GO:0048705 203 0.281
mesenchyme development GO:0060485 152 0.279
modification dependent macromolecule catabolic process GO:0043632 133 0.277
formation of radial glial scaffolds GO:0021943 4 0.275
ameboidal type cell migration GO:0001667 128 0.273
single organism nuclear import GO:1902593 95 0.273
Mouse
cell fate specification GO:0001708 72 0.270
nephron tubule morphogenesis GO:0072078 68 0.269
Mouse
tube formation GO:0035148 140 0.268
regulation of cellular response to growth factor stimulus GO:0090287 82 0.268
Human Mouse
positive regulation of kinase activity GO:0033674 155 0.267
morphogenesis of a branching epithelium GO:0061138 193 0.267
Mouse
cell aging GO:0007569 35 0.266
cell fate determination GO:0001709 32 0.264
positive regulation of smad protein import into nucleus GO:0060391 2 0.260
Mouse
embryonic epithelial tube formation GO:0001838 130 0.257
cytoplasmic transport GO:0016482 234 0.257
Mouse
bone development GO:0060348 120 0.250
Mouse
peptidyl amino acid modification GO:0018193 336 0.249
Mouse
respiratory tube development GO:0030323 167 0.249
mesoderm development GO:0007498 100 0.248
wnt signaling pathway GO:0016055 188 0.245
neural tube closure GO:0001843 90 0.241
regulation of peptidyl threonine phosphorylation GO:0010799 12 0.241
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.239
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.239
response to bmp GO:0071772 14 0.236
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.236
Mouse
palate development GO:0060021 76 0.235
asymmetric neuroblast division GO:0055059 1 0.233
positive regulation of apoptotic signaling pathway GO:2001235 95 0.232
developmental growth involved in morphogenesis GO:0060560 138 0.231
molting cycle GO:0042303 90 0.228
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.227
asymmetric stem cell division GO:0098722 3 0.226
synapse organization GO:0050808 125 0.224
gonad development GO:0008406 141 0.223
positive regulation of mapk cascade GO:0043410 170 0.221
organ growth GO:0035265 117 0.221
regulation of pathway restricted smad protein phosphorylation GO:0060393 6 0.221
Mouse
transforming growth factor beta2 production GO:0032906 2 0.220
protein localization to organelle GO:0033365 185 0.218
Mouse
positive regulation of ossification GO:0045778 47 0.214
Mouse
phagocytosis GO:0006909 66 0.212
morphogenesis of embryonic epithelium GO:0016331 159 0.211
pigmentation GO:0043473 71 0.210
establishment or maintenance of cell polarity GO:0007163 86 0.209
carbon catabolite activation of transcription GO:0045991 4 0.209
organonitrogen compound biosynthetic process GO:1901566 192 0.209
establishment or maintenance of apical basal cell polarity GO:0035088 21 0.206
epidermis development GO:0008544 187 0.205
Mouse
pole plasm assembly GO:0007315 2 0.204
regulation of cellular amino acid metabolic process GO:0006521 5 0.204
heart field specification GO:0003128 6 0.204
chemotaxis GO:0006935 247 0.199
Mouse
stem cell development GO:0048864 219 0.198
epithelial tube formation GO:0072175 130 0.196
embryonic organ morphogenesis GO:0048562 276 0.194
negative regulation of neuron differentiation GO:0045665 101 0.194
renal tubule development GO:0061326 87 0.191
Mouse
neural tube formation GO:0001841 108 0.190
peptidyl tyrosine phosphorylation GO:0018108 143 0.190
canonical wnt signaling pathway GO:0060070 130 0.190
appendage development GO:0048736 166 0.189
regulation of protein localization GO:0032880 231 0.185
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.182
Mouse
ribose phosphate biosynthetic process GO:0046390 59 0.181
neuron projection extension GO:1990138 64 0.180
regulation of cytoplasmic transport GO:1903649 112 0.178
Mouse
vesicle localization GO:0051648 86 0.177
negative regulation of intracellular signal transduction GO:1902532 167 0.175
regulation of cellular amine metabolic process GO:0033238 20 0.174
mitotic cell cycle process GO:1903047 159 0.171
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.170
camp biosynthetic process GO:0006171 31 0.169
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.169
Mouse
actin cytoskeleton organization GO:0030036 220 0.168
kidney development GO:0001822 213 0.168
myeloid leukocyte differentiation GO:0002573 119 0.166
protein import GO:0017038 101 0.165
Mouse
regulation of nucleotide biosynthetic process GO:0030808 34 0.164
regulation of protein transport GO:0051223 163 0.164
Mouse
protein autophosphorylation GO:0046777 61 0.163
jnk cascade GO:0007254 72 0.161
regulation of protein serine threonine kinase activity GO:0071900 157 0.161
schwann cell proliferation GO:0014010 2 0.160
angiogenesis GO:0001525 201 0.159
regulation of organelle organization GO:0033043 289 0.159
male gamete generation GO:0048232 285 0.158
regulation of bmp signaling pathway GO:0030510 60 0.157
Human Mouse
positive regulation of cytoplasmic transport GO:1903651 40 0.157
Mouse
positive regulation of protein import into nucleus GO:0042307 26 0.157
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.156
Human Mouse
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.155
cyclic nucleotide biosynthetic process GO:0009190 44 0.154
metencephalon development GO:0022037 89 0.154
response to transforming growth factor beta GO:0071559 88 0.154
activation of adenylate cyclase activity GO:0007190 4 0.153
nephron epithelium morphogenesis GO:0072088 68 0.153
Mouse
endochondral bone morphogenesis GO:0060350 50 0.153
sperm ejaculation GO:0042713 1 0.152
positive regulation of intracellular protein transport GO:0090316 42 0.149
Mouse
cell growth GO:0016049 130 0.149
cellular protein catabolic process GO:0044257 155 0.149
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.149
oocyte anterior posterior axis specification GO:0007314 2 0.149
neural tube development GO:0021915 160 0.148
fat cell differentiation GO:0045444 160 0.148
branching morphogenesis of an epithelial tube GO:0048754 159 0.147
Mouse
positive regulation of glial cell proliferation GO:0060252 4 0.147
segmentation GO:0035282 93 0.145
Mouse
regulation of cell motility GO:2000145 236 0.145
heart valve morphogenesis GO:0003179 21 0.144
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.144
positive regulation of cell motility GO:2000147 116 0.143
hormone secretion GO:0046879 128 0.141
cyclic nucleotide metabolic process GO:0009187 59 0.141
central nervous system neuron development GO:0021954 67 0.140
oogenesis GO:0048477 56 0.140
Zebrafish
ribonucleotide biosynthetic process GO:0009260 59 0.140
myeloid cell homeostasis GO:0002262 114 0.140
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.140
regulation of cell migration GO:0030334 219 0.139
epithelial to mesenchymal transition GO:0001837 47 0.138
protein modification by small protein conjugation or removal GO:0070647 207 0.138
cardiac chamber morphogenesis GO:0003206 93 0.137
Mouse
retina vasculature development in camera type eye GO:0061298 17 0.137
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.136
neural precursor cell proliferation GO:0061351 121 0.135
skin development GO:0043588 220 0.135
Mouse
chondrocyte differentiation GO:0002062 72 0.135
Mouse
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.135
response to monosaccharide GO:0034284 67 0.133
regulation of protein stability GO:0031647 52 0.131
regulation of mitotic cell cycle GO:0007346 126 0.129
Worm
regulation of canonical wnt signaling pathway GO:0060828 82 0.128
negative regulation of bmp signaling pathway GO:0030514 35 0.128
Mouse
neuron apoptotic process GO:0051402 142 0.128
engulfment of apoptotic cell GO:0043652 3 0.128
morphogenesis of a branching structure GO:0001763 203 0.128
Mouse
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.127
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.127
regulation of defense response GO:0031347 233 0.127
Mouse
regulation of secretion GO:0051046 274 0.126
purine ribonucleotide biosynthetic process GO:0009152 59 0.126
nucleocytoplasmic transport GO:0006913 139 0.126
Mouse
regulation of erythrocyte differentiation GO:0045646 23 0.125
negative regulation of apoptotic signaling pathway GO:2001234 104 0.125
regulation of cellular protein catabolic process GO:1903362 61 0.125
positive regulation of apoptotic process GO:0043065 217 0.125
ubiquitin dependent protein catabolic process GO:0006511 129 0.124
carbohydrate derivative biosynthetic process GO:1901137 183 0.123
regulation of system process GO:0044057 200 0.123
Mouse
regulation of actin cytoskeleton organization GO:0032956 84 0.122
foregut morphogenesis GO:0007440 12 0.122
regulation of cellular catabolic process GO:0031329 242 0.121
mesoderm formation GO:0001707 62 0.119
embryonic heart tube morphogenesis GO:0003143 51 0.118
Mouse
regulation of intracellular transport GO:0032386 159 0.118
Mouse
formation of anatomical boundary GO:0048859 6 0.117
Mouse
mesenchymal cell development GO:0014031 93 0.116
mesenchyme morphogenesis GO:0072132 32 0.116
regulation of cellular component size GO:0032535 121 0.114
regulation of cellular component biogenesis GO:0044087 181 0.114
bmp signaling pathway GO:0030509 93 0.113
Human Mouse
regulation of wnt signaling pathway GO:0030111 123 0.113
ribose phosphate metabolic process GO:0019693 291 0.113
regulation of muscle tissue development GO:1901861 97 0.112
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.112
protein processing GO:0016485 163 0.111
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.111
regulation of synapse assembly GO:0051963 29 0.111
nuclear import GO:0051170 95 0.110
Mouse
mesoderm morphogenesis GO:0048332 64 0.110
apoptotic signaling pathway GO:0097190 306 0.110
ventricular septum development GO:0003281 42 0.110
Mouse
positive regulation of transcription by galactose GO:0000411 1 0.108
neuroblast division GO:0055057 10 0.107
formation of primary germ layer GO:0001704 77 0.107
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.107
Human Mouse
wound healing GO:0042060 157 0.107
Mouse
cell cycle arrest GO:0007050 37 0.106
ubiquitin dependent smad protein catabolic process GO:0030579 2 0.106
cell division GO:0051301 120 0.106
positive regulation of transferase activity GO:0051347 167 0.106
protein targeting GO:0006605 143 0.106
Mouse
positive regulation of programmed cell death GO:0043068 218 0.106
regulation of epithelial cell proliferation GO:0050678 141 0.105
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.103
amide transport GO:0042886 138 0.103
odontogenesis GO:0042476 78 0.103
regulation of t cell activation GO:0050863 170 0.103
regulation of cytoskeleton organization GO:0051493 122 0.103
ventricular septum morphogenesis GO:0060412 27 0.102
Mouse
modification dependent protein catabolic process GO:0019941 133 0.101
purine nucleotide biosynthetic process GO:0006164 65 0.101
intracellular protein transport GO:0006886 204 0.101
Mouse
regulation of cell adhesion GO:0030155 154 0.100
Mouse
cardiac endothelial cell differentiation GO:0003348 4 0.100
Mouse
stem cell proliferation GO:0072089 117 0.099
branching involved in ureteric bud morphogenesis GO:0001658 56 0.098
Mouse
methylation GO:0032259 134 0.097
inner ear receptor cell differentiation GO:0060113 61 0.096
response to organic cyclic compound GO:0014070 198 0.095
Human Mouse
ribonucleotide metabolic process GO:0009259 291 0.095
immune response activating signal transduction GO:0002757 116 0.095
regulation of intracellular protein transport GO:0033157 82 0.095
Mouse
neural crest cell differentiation GO:0014033 54 0.095
Mouse
cell maturation GO:0048469 127 0.093
regulation of cellular ketone metabolic process GO:0010565 66 0.093
nitrogen compound transport GO:0071705 271 0.093
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.093
Mouse
mesodermal cell fate commitment GO:0001710 17 0.093
Mouse
regulation of protein catabolic process GO:0042176 108 0.092
dna endoreduplication GO:0042023 4 0.090
cardiac muscle tissue development GO:0048738 130 0.090
Mouse
positive regulation of myeloid cell differentiation GO:0045639 43 0.089
camp metabolic process GO:0046058 40 0.088
spermatid differentiation GO:0048515 115 0.087
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.086
purine containing compound biosynthetic process GO:0072522 70 0.086
negative regulation of growth GO:0045926 99 0.086
regulation of proteasomal protein catabolic process GO:0061136 46 0.086
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.086
positive regulation of cell death GO:0010942 224 0.084
cardiocyte differentiation GO:0035051 87 0.084
Mouse
nucleoside metabolic process GO:0009116 246 0.084
renal system development GO:0072001 225 0.084
biomineral tissue development GO:0031214 64 0.084
regulation of biomineral tissue development GO:0070167 33 0.084
endocytosis GO:0006897 168 0.084
activin receptor signaling pathway GO:0032924 18 0.083
Human
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.083
bone morphogenesis GO:0060349 78 0.082
regulation of actin filament based process GO:0032970 99 0.082
negative regulation of defense response GO:0031348 77 0.082
Mouse
regulation of anatomical structure size GO:0090066 178 0.082
activation of immune response GO:0002253 138 0.082
positive regulation of cellular amine metabolic process GO:0033240 5 0.082
regulation of nucleocytoplasmic transport GO:0046822 73 0.081
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.081
embryonic heart tube development GO:0035050 65 0.081
Mouse
macroautophagy GO:0016236 21 0.080
regulation of cellular response to stress GO:0080135 159 0.080
mesonephric tubule morphogenesis GO:0072171 63 0.079
Mouse
ureteric bud development GO:0001657 94 0.078
cellular ketone metabolic process GO:0042180 84 0.078
negative regulation of nervous system development GO:0051961 156 0.078
hair follicle development GO:0001942 85 0.077
Mouse
regulation of transcription by galactose GO:0000409 1 0.077
organelle localization GO:0051640 179 0.077
rna localization GO:0006403 23 0.077
ras protein signal transduction GO:0007265 77 0.076
regulation of secretion by cell GO:1903530 249 0.076
response to radiation GO:0009314 165 0.076
heart morphogenesis GO:0003007 178 0.076
Mouse
regulation of hydrolase activity GO:0051336 246 0.075
kidney morphogenesis GO:0060993 83 0.075
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.075
Mouse
lens morphogenesis in camera type eye GO:0002089 24 0.074
positive regulation of neuron projection development GO:0010976 79 0.074
fibroblast migration GO:0010761 21 0.074
striated muscle tissue development GO:0014706 293 0.074
Mouse
lipid localization GO:0010876 126 0.073
regulation of vasculature development GO:1901342 88 0.073
cellular response to lipid GO:0071396 145 0.073
peptide hormone secretion GO:0030072 109 0.073
determination of heart left right asymmetry GO:0061371 48 0.073
Mouse
synaptic transmission GO:0007268 329 0.073
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.073
regulation of epithelial to mesenchymal transition GO:0010717 22 0.073
negative regulation of phosphorus metabolic process GO:0010563 184 0.072
Mouse
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.072
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.072
nephron tubule development GO:0072080 84 0.072
Mouse
blastoderm segmentation GO:0007350 13 0.072
protein catabolic process GO:0030163 221 0.072
lymphocyte homeostasis GO:0002260 64 0.071
cellular response to abiotic stimulus GO:0071214 56 0.071
pancreas development GO:0031016 57 0.071
regulation of binding GO:0051098 111 0.071
central nervous system maturation GO:0021626 6 0.071
regulation of neuron apoptotic process GO:0043523 122 0.071
response to drug GO:0042493 75 0.071
ureteric bud morphogenesis GO:0060675 62 0.070
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.069
regulation of kinase activity GO:0043549 249 0.069
gland development GO:0048732 330 0.069
Mouse
negative regulation of wound healing GO:0061045 14 0.068
Mouse
maintenance of location GO:0051235 89 0.068
positive regulation of protein transport GO:0051222 93 0.068
Mouse
mechanoreceptor differentiation GO:0042490 67 0.068
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.068
peptidyl threonine phosphorylation GO:0018107 31 0.068
Mouse
positive regulation of cell migration GO:0030335 109 0.068
circulatory system process GO:0003013 197 0.067
Mouse
embryonic hindlimb morphogenesis GO:0035116 32 0.067
nucleobase containing small molecule metabolic process GO:0055086 352 0.067
negative regulation of protein phosphorylation GO:0001933 126 0.067
Mouse
somitogenesis GO:0001756 69 0.067
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.067
retina development in camera type eye GO:0060041 119 0.065
mammary gland morphogenesis GO:0060443 54 0.065
cyclic purine nucleotide metabolic process GO:0052652 43 0.065
antigen receptor mediated signaling pathway GO:0050851 64 0.065
positive regulation of camp metabolic process GO:0030816 19 0.064
mammary gland epithelium development GO:0061180 65 0.064
negative regulation of cell development GO:0010721 169 0.063
regulation of nucleotide metabolic process GO:0006140 169 0.063
embryonic skeletal joint development GO:0072498 13 0.063
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.063
cytokine biosynthetic process GO:0042089 68 0.063
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.063
negative regulation of cell cycle GO:0045786 123 0.063
Worm
blood circulation GO:0008015 195 0.063
Mouse
regulation of protein localization to nucleus GO:1900180 60 0.062
Mouse
lung morphogenesis GO:0060425 50 0.062
primary neural tube formation GO:0014020 95 0.062
locomotory behavior GO:0007626 195 0.062
regulation of fat cell differentiation GO:0045598 81 0.062
peptide secretion GO:0002790 114 0.062
anatomical structure homeostasis GO:0060249 145 0.061
positive regulation of cell projection organization GO:0031346 95 0.061
mesodermal cell differentiation GO:0048333 22 0.061
Mouse
smad protein import into nucleus GO:0007184 6 0.060
Mouse
negative regulation of protein modification process GO:0031400 163 0.060
Mouse
nephron morphogenesis GO:0072028 69 0.060
Mouse
carbon catabolite regulation of transcription GO:0045990 4 0.060
kidney epithelium development GO:0072073 121 0.060
peptidyl serine phosphorylation GO:0018105 74 0.060
Mouse
nucleoside phosphate biosynthetic process GO:1901293 79 0.060
oocyte differentiation GO:0009994 35 0.060
Zebrafish
endodermal cell fate commitment GO:0001711 12 0.060
regulation of camp biosynthetic process GO:0030817 25 0.059
mesonephric epithelium development GO:0072163 94 0.059
microtubule severing GO:0051013 5 0.059
b cell homeostasis GO:0001782 34 0.059
negative regulation of dna replication GO:0008156 4 0.059
nuclear transport GO:0051169 139 0.059
Mouse
cardiac chamber development GO:0003205 108 0.059
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 73 0.058
synaptic growth at neuromuscular junction GO:0051124 6 0.058
regulation of homeostatic process GO:0032844 182 0.058
regulation of transcription factor import into nucleus GO:0042990 24 0.058
embryonic hemopoiesis GO:0035162 23 0.057
regulation of heart contraction GO:0008016 77 0.057
Mouse
limb development GO:0060173 166 0.057
cardiac ventricle morphogenesis GO:0003208 50 0.057
Mouse
photoreceptor cell morphogenesis GO:0008594 3 0.056
immune response regulating signaling pathway GO:0002764 125 0.056
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.055
ribonucleoside metabolic process GO:0009119 245 0.055
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.055
membrane organization GO:0061024 245 0.055
adult locomotory behavior GO:0008344 91 0.055
trachea formation GO:0060440 3 0.054
cell junction assembly GO:0034329 52 0.054
regulation of tube size GO:0035150 57 0.054
establishment of organelle localization GO:0051656 122 0.054
regulation of body fluid levels GO:0050878 162 0.054
positive regulation of nucleotide metabolic process GO:0045981 114 0.053
positive regulation of intracellular transport GO:0032388 70 0.053
Mouse
positive regulation of erythrocyte differentiation GO:0045648 11 0.053
regulation of map kinase activity GO:0043405 120 0.053
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.053
Mouse
peptidyl threonine modification GO:0018210 31 0.053
Mouse
organophosphate biosynthetic process GO:0090407 122 0.052
trachea development GO:0060438 18 0.052
cardiac muscle cell proliferation GO:0060038 31 0.052
Mouse
negative regulation of cell motility GO:2000146 61 0.052
cell adhesion GO:0007155 329 0.052
Mouse
regulation of cell growth GO:0001558 91 0.052
neuron maturation GO:0042551 29 0.052
regulation of stem cell differentiation GO:2000736 50 0.052
regulation of muscle contraction GO:0006937 49 0.051
Mouse
regulation of hormone levels GO:0010817 211 0.051
regulation of establishment of protein localization GO:0070201 181 0.051
Mouse
microtubule based process GO:0007017 236 0.051
hindlimb morphogenesis GO:0035137 42 0.051
t cell differentiation GO:0030217 174 0.051
embryonic digit morphogenesis GO:0042733 56 0.051
centromeric sister chromatid cohesion GO:0070601 3 0.051

Smad2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.718
cancer DOID:162 0 0.659
large intestine cancer DOID:5672 0 0.160
colon cancer DOID:219 0 0.160
gastrointestinal system cancer DOID:3119 0 0.160
intestinal cancer DOID:10155 0 0.160
organ system cancer DOID:0050686 0 0.160
colorectal cancer DOID:9256 0 0.160