Mus musculus

371 known processes

Smad4

MAD homolog 4 (Drosophila)

(Aliases: AW743858,D18Wsu70e,Madh4,DPC4)

Smad4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell proliferation involved in heart valve morphogenesis GO:0003249 1 1.000
nephrogenic mesenchyme morphogenesis GO:0072134 2 1.000
kidney mesenchyme morphogenesis GO:0072131 4 1.000
metanephric mesenchyme morphogenesis GO:0072133 4 1.000
endothelial cell activation GO:0042118 1 1.000
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 1.000
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 1.000
Mouse
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 1.000
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 1.000
Mouse
germ line stem cell division GO:0042078 2 1.000
Fly
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 1.000
negative regulation of peptidyl serine phosphorylation GO:0033137 10 1.000
Mouse
cell proliferation involved in heart valve development GO:2000793 2 1.000
digestive system development GO:0055123 200 1.000
response to sterol GO:0036314 4 1.000
digestive tract development GO:0048565 190 1.000
brainstem development GO:0003360 3 1.000
digestive tract morphogenesis GO:0048546 147 0.999
osteoblast fate commitment GO:0002051 4 0.999
Mouse
negative regulation of osteoblast proliferation GO:0033689 4 0.999
Mouse
regulation of cell proliferation involved in heart valve morphogenesis GO:0003250 1 0.999
gastrulation GO:0007369 116 0.998
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.998
t cell activation GO:0042110 289 0.998
Mouse
cell cycle switching GO:0060184 1 0.998
positive regulation of smad protein import into nucleus GO:0060391 2 0.998
osteoblast development GO:0002076 17 0.998
Mouse
regulation of cell adhesion GO:0030155 154 0.995
Mouse
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.995
Fly
negative regulation of cell cycle GO:0045786 123 0.995
positive regulation of stem cell differentiation GO:2000738 23 0.994
nephrogenic mesenchyme development GO:0072076 3 0.994
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.993
mesenchyme morphogenesis GO:0072132 32 0.992
myeloid cell homeostasis GO:0002262 114 0.991
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.991
erythrocyte differentiation GO:0030218 88 0.991
Mouse
embryonic skeletal system development GO:0048706 120 0.990
Mouse
regulation of bmp signaling pathway GO:0030510 60 0.989
Human Mouse
stem cell differentiation GO:0048863 268 0.989
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.989
oocyte axis specification GO:0007309 2 0.988
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.987
cell adhesion GO:0007155 329 0.986
Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.985
smad protein complex assembly GO:0007183 1 0.985
Human
regionalization GO:0003002 337 0.984
positive regulation of bmp signaling pathway GO:0030513 23 0.984
Human
axon guidance GO:0007411 141 0.984
regulation of peptidyl threonine phosphorylation GO:0010799 12 0.983
Mouse
lens development in camera type eye GO:0002088 62 0.983
Mouse
homeostasis of number of cells GO:0048872 210 0.982
Mouse
axonogenesis GO:0007409 274 0.982
molting cycle GO:0042303 90 0.982
neuron projection guidance GO:0097485 141 0.981
paraxial mesoderm morphogenesis GO:0048340 10 0.980
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.980
germ cell development GO:0007281 185 0.979
Mouse Fly
response to bmp GO:0071772 14 0.978
Mouse
mesendoderm development GO:0048382 3 0.977
regulation of smad protein import into nucleus GO:0060390 3 0.977
wound healing GO:0042060 157 0.976
Mouse
peptidyl amino acid modification GO:0018193 336 0.975
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.973
pathway restricted smad protein phosphorylation GO:0060389 10 0.971
regulation of cellular amino acid metabolic process GO:0006521 5 0.971
striated muscle tissue development GO:0014706 293 0.971
Mouse
cellular amine metabolic process GO:0044106 44 0.970
camera type eye development GO:0043010 266 0.970
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.970
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.969
Mouse
blood vessel morphogenesis GO:0048514 285 0.968
Mouse
regulation of pathway restricted smad protein phosphorylation GO:0060393 6 0.967
endocardial cushion morphogenesis GO:0003203 18 0.967
response to growth factor GO:0070848 198 0.966
neural tube development GO:0021915 160 0.965
endoderm formation GO:0001706 20 0.964
Mouse
female gamete generation GO:0007292 74 0.964
Fly
endoderm development GO:0007492 45 0.963
regulation of peptidyl serine phosphorylation GO:0033135 39 0.963
Mouse
response to cholesterol GO:0070723 4 0.961
embryonic organ morphogenesis GO:0048562 276 0.960
Mouse
body morphogenesis GO:0010171 45 0.960
Worm
filopodium assembly GO:0046847 19 0.960
gland development GO:0048732 330 0.959
foregut morphogenesis GO:0007440 12 0.959
Mouse
regulation of osteoblast differentiation GO:0045667 67 0.959
Mouse
single organism cell adhesion GO:0098602 156 0.958
Mouse
endothelium development GO:0003158 45 0.957
regulation of cell cycle GO:0051726 281 0.957
lymphocyte differentiation GO:0030098 242 0.957
activin receptor signaling pathway GO:0032924 18 0.955
endocardial cushion formation GO:0003272 13 0.954
artery development GO:0060840 53 0.949
Mouse
t cell differentiation GO:0030217 174 0.949
peptidyl threonine modification GO:0018210 31 0.948
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.946
endocardial cushion development GO:0003197 26 0.945
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.945
oogenesis GO:0048477 56 0.945
Fly
lung development GO:0030324 164 0.945
Mouse
mesenchyme development GO:0060485 152 0.945
bmp signaling pathway GO:0030509 93 0.943
Human Mouse
schwann cell proliferation GO:0014010 2 0.943
respiratory system development GO:0060541 190 0.942
Mouse
regulation of osteoblast proliferation GO:0033688 15 0.941
Mouse
mammary gland morphogenesis GO:0060443 54 0.941
negative regulation of bmp signaling pathway GO:0030514 35 0.941
Mouse
oocyte construction GO:0007308 2 0.940
cardiac chamber development GO:0003205 108 0.939
embryonic hemopoiesis GO:0035162 23 0.939
dna metabolic process GO:0006259 303 0.938
organ growth GO:0035265 117 0.937
Mouse Worm
epidermis development GO:0008544 187 0.936
epithelial tube morphogenesis GO:0060562 303 0.936
skin development GO:0043588 220 0.934
regulation of defense response GO:0031347 233 0.934
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.933
positive regulation of protein modification process GO:0031401 299 0.930
negative regulation of t cell proliferation GO:0042130 38 0.928
regulation of stem cell differentiation GO:2000736 50 0.926
tolerance induction to self antigen GO:0002513 4 0.922
endocardial cell differentiation GO:0060956 4 0.922
regulation of hair follicle development GO:0051797 9 0.920
stem cell development GO:0048864 219 0.919
pole plasm assembly GO:0007315 2 0.919
formation of anatomical boundary GO:0048859 6 0.918
mitotic cell cycle GO:0000278 195 0.916
inflammatory response GO:0006954 244 0.916
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.914
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.911
Mouse
metanephric mesenchyme development GO:0072075 10 0.910
immune response activating signal transduction GO:0002757 116 0.910
oocyte differentiation GO:0009994 35 0.909
protein localization to nucleus GO:0034504 121 0.908
peptidyl threonine phosphorylation GO:0018107 31 0.907
Mouse
myeloid cell differentiation GO:0030099 233 0.904
Mouse
respiratory tube development GO:0030323 167 0.902
Mouse
endodermal cell fate commitment GO:0001711 12 0.901
positive regulation of osteoblast differentiation GO:0045669 34 0.899
Mouse
neural tube closure GO:0001843 90 0.891
negative regulation of cell proliferation GO:0008285 296 0.890
peptidyl serine phosphorylation GO:0018105 74 0.888
Mouse
multicellular organism growth GO:0035264 161 0.886
Worm
cellular response to organic cyclic compound GO:0071407 87 0.885
Mouse
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.881
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.881
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.881
Human Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.881
cardiac endothelial cell differentiation GO:0003348 4 0.881
regulation of mapk cascade GO:0043408 248 0.879
regulation of epithelial cell proliferation GO:0050678 141 0.878
Mouse
atrioventricular valve formation GO:0003190 5 0.878
blastoderm segmentation GO:0007350 13 0.876
cardiac muscle cell proliferation GO:0060038 31 0.875
Mouse
cardiac epithelial to mesenchymal transition GO:0060317 18 0.873
atrioventricular canal development GO:0036302 5 0.872
lymphocyte homeostasis GO:0002260 64 0.872
amine metabolic process GO:0009308 45 0.871
spermatid differentiation GO:0048515 115 0.870
positive regulation of gene silencing by mirna GO:2000637 1 0.870
cellular amino acid metabolic process GO:0006520 103 0.869
mammary gland epithelium development GO:0061180 65 0.863
regulation of binding GO:0051098 111 0.863
regulation of cell cycle phase transition GO:1901987 77 0.863
chemotaxis GO:0006935 247 0.861
mesenchymal cell differentiation GO:0048762 107 0.860
metencephalon development GO:0022037 89 0.860
regulation of muscle contraction GO:0006937 49 0.857
Mouse
gastrulation with mouth forming second GO:0001702 29 0.856
smad protein import into nucleus GO:0007184 6 0.856
leukocyte differentiation GO:0002521 342 0.844
myeloid leukocyte differentiation GO:0002573 119 0.844
regulation of cardiac muscle contraction GO:0055117 21 0.843
Mouse
regulation of protein import into nucleus GO:0042306 52 0.841
cardiac muscle tissue growth GO:0055017 37 0.839
Mouse
actin cytoskeleton organization GO:0030036 220 0.836
single organismal cell cell adhesion GO:0016337 131 0.835
Mouse
alpha beta t cell differentiation GO:0046632 69 0.834
connective tissue development GO:0061448 179 0.832
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.829
Mouse
response to organic cyclic compound GO:0014070 198 0.820
Mouse
response to transforming growth factor beta GO:0071559 88 0.820
mechanoreceptor differentiation GO:0042490 67 0.815
regulation of hair cycle GO:0042634 11 0.814
regulation of muscle system process GO:0090257 80 0.814
Mouse
negative regulation of immune system process GO:0002683 209 0.813
regulation of protein stability GO:0031647 52 0.813
negative regulation of protein metabolic process GO:0051248 282 0.811
Human Mouse
muscle contraction GO:0006936 101 0.811
Mouse
skeletal system morphogenesis GO:0048705 203 0.807
Mouse
negative regulation of osteoblast differentiation GO:0045668 30 0.807
Mouse
mesoderm morphogenesis GO:0048332 64 0.806
Mouse
regulation of blood circulation GO:1903522 93 0.803
Mouse
ventricular septum development GO:0003281 42 0.802
Mouse
nodal signaling pathway GO:0038092 10 0.802
heart valve morphogenesis GO:0003179 21 0.802
muscle system process GO:0003012 141 0.801
Mouse
negative regulation of cell cycle phase transition GO:1901988 48 0.800
sebaceous gland development GO:0048733 7 0.798
cardiac ventricle morphogenesis GO:0003208 50 0.798
Mouse
embryonic heart tube morphogenesis GO:0003143 51 0.796
Mouse
palate development GO:0060021 76 0.793
liver development GO:0001889 66 0.790
Mouse
heart valve formation GO:0003188 10 0.789
placenta development GO:0001890 140 0.788
hair cycle GO:0042633 90 0.788
regulation of neuron differentiation GO:0045664 281 0.787
regulation of t cell activation GO:0050863 170 0.786
chondrocyte differentiation GO:0002062 72 0.785
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.784
mesoderm formation GO:0001707 62 0.783
Mouse
regulation of epithelial to mesenchymal transition GO:0010717 22 0.783
dendrite development GO:0016358 115 0.780
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.775
cellular response to dna damage stimulus GO:0006974 207 0.772
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.771
endothelial cell differentiation GO:0045446 41 0.771
positive regulation of intracellular protein transport GO:0090316 42 0.768
negative regulation of response to wounding GO:1903035 77 0.766
Mouse
muscle tissue development GO:0060537 308 0.764
Mouse
positive regulation of intracellular transport GO:0032388 70 0.754
mesenchymal cell development GO:0014031 93 0.754
hindbrain development GO:0030902 128 0.750
Mouse
fused antrum stage GO:0048165 1 0.748
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.748
protein localization to organelle GO:0033365 185 0.744
ameboidal type cell migration GO:0001667 128 0.743
regulation of t cell differentiation GO:0045580 83 0.743
hair follicle development GO:0001942 85 0.742
oocyte anterior posterior axis specification GO:0007314 2 0.738
embryonic epithelial tube formation GO:0001838 130 0.734
spermatogenesis GO:0007283 284 0.728
embryonic digit morphogenesis GO:0042733 56 0.725
nuclear transport GO:0051169 139 0.722
positive regulation of activin receptor signaling pathway GO:0032927 3 0.719
mesodermal cell differentiation GO:0048333 22 0.719
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.718
cardiocyte differentiation GO:0035051 87 0.717
regulation of organelle organization GO:0033043 289 0.717
nephron tubule morphogenesis GO:0072078 68 0.711
cell fate determination GO:0001709 32 0.709
negative regulation of defense response GO:0031348 77 0.707
Mouse
regulation of epidermis development GO:0045682 33 0.702
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.701
negative regulation of cellular amine metabolic process GO:0033239 1 0.701
positive regulation of meiotic cell cycle GO:0051446 15 0.700
regulation of endothelial cell differentiation GO:0045601 10 0.698
regulation of blood vessel size GO:0050880 56 0.695
regulation of muscle tissue development GO:1901861 97 0.692
Mouse
regulation of alpha beta t cell differentiation GO:0046637 35 0.689
blood circulation GO:0008015 195 0.689
Mouse
somite development GO:0061053 81 0.689
embryonic limb morphogenesis GO:0030326 126 0.687
formation of primary germ layer GO:0001704 77 0.683
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.682
Fly
regulation of cellular response to growth factor stimulus GO:0090287 82 0.681
Human Mouse
regulation of organ morphogenesis GO:2000027 144 0.679
cardiac muscle tissue development GO:0048738 130 0.676
Mouse
positive regulation of immature t cell proliferation GO:0033091 4 0.676
cartilage development GO:0051216 140 0.673
Mouse
antral ovarian follicle growth GO:0001547 5 0.670
cellular response to lipid GO:0071396 145 0.666
transdifferentiation GO:0060290 1 0.666
negative regulation of protein modification process GO:0031400 163 0.664
Mouse
regulation of histone acetylation GO:0035065 19 0.663
cardiac chamber morphogenesis GO:0003206 93 0.660
Mouse
inner ear receptor cell differentiation GO:0060113 61 0.658
lymphocyte proliferation GO:0046651 164 0.658
retinal ganglion cell axon guidance GO:0031290 18 0.657
Fly
cognition GO:0050890 149 0.653
leukocyte proliferation GO:0070661 172 0.650
mapk cascade GO:0000165 281 0.650
Mouse
t cell differentiation in thymus GO:0033077 77 0.650
gene silencing by mirna GO:0035195 10 0.648
somite rostral caudal axis specification GO:0032525 13 0.647
striated muscle cell proliferation GO:0014855 39 0.647
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.644
Mouse
epithelial cell proliferation GO:0050673 174 0.642
Mouse
protein targeting GO:0006605 143 0.640
positive regulation of protein import into nucleus GO:0042307 26 0.640
odontogenesis of dentin containing tooth GO:0042475 66 0.638
stem cell maintenance GO:0019827 130 0.637
Fly
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 5 0.637
mesenchymal cell proliferation GO:0010463 44 0.634
cellular macromolecule catabolic process GO:0044265 206 0.633
odontogenesis GO:0042476 78 0.631
heart morphogenesis GO:0003007 178 0.629
cell migration involved in gastrulation GO:0042074 13 0.625
positive regulation of cytoplasmic transport GO:1903651 40 0.625
cell aging GO:0007569 35 0.624
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.623
Fly
endodermal cell fate specification GO:0001714 4 0.621
tolerance induction GO:0002507 14 0.619
epithelial to mesenchymal transition GO:0001837 47 0.619
endocrine system development GO:0035270 98 0.616
Mouse
activation of immune response GO:0002253 138 0.611
positive regulation of neuron differentiation GO:0045666 141 0.610
trunk segmentation GO:0035290 4 0.609
appendage development GO:0048736 166 0.608
Fly
immune response regulating signaling pathway GO:0002764 125 0.607
bronchus development GO:0060433 10 0.605
regulation of ossification GO:0030278 112 0.598
Mouse
lateral mesodermal cell differentiation GO:0048371 3 0.596
positive regulation of cell development GO:0010720 237 0.595
angiogenesis GO:0001525 201 0.589
hepaticobiliary system development GO:0061008 67 0.589
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.588
muscle cell development GO:0055001 133 0.588
bone development GO:0060348 120 0.585
Mouse
paraxial mesoderm development GO:0048339 18 0.585
Mouse
determination of left right symmetry GO:0007368 80 0.585
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.584
heart field specification GO:0003128 6 0.583
engulfment of apoptotic cell GO:0043652 3 0.581
regulation of protein targeting GO:1903533 61 0.578
urogenital system development GO:0001655 261 0.578
negative regulation of intracellular signal transduction GO:1902532 167 0.576
chondrocyte development GO:0002063 24 0.574
maternal process involved in female pregnancy GO:0060135 32 0.573
cell fate commitment GO:0045165 210 0.572
neural crest cell differentiation GO:0014033 54 0.570
gonad development GO:0008406 141 0.570
positive regulation of apoptotic signaling pathway GO:2001235 95 0.568
regulation of cytokine production GO:0001817 266 0.567
Human
response to monosaccharide GO:0034284 67 0.567
Mouse
male gamete generation GO:0048232 285 0.565
cellular ketone metabolic process GO:0042180 84 0.561
leukocyte homeostasis GO:0001776 79 0.559
regulation of apoptotic signaling pathway GO:2001233 197 0.558
negative regulation of phosphorylation GO:0042326 166 0.556
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.555
Mouse
embryonic axis specification GO:0000578 30 0.554
positive regulation of cytokine production GO:0001819 174 0.550
developmental maturation GO:0021700 193 0.548
blastocyst development GO:0001824 80 0.546
oocyte development GO:0048599 33 0.545
common partner smad protein phosphorylation GO:0007182 2 0.544
regulation of mitotic cell cycle phase transition GO:1901990 73 0.544
negative regulation of organ growth GO:0046621 17 0.542
kidney development GO:0001822 213 0.537
intracellular receptor signaling pathway GO:0030522 74 0.523
embryonic placenta development GO:0001892 98 0.523
maternal placenta development GO:0001893 20 0.521
cytoplasmic transport GO:0016482 234 0.519
regulation of tolerance induction GO:0002643 10 0.519
regulation of intracellular transport GO:0032386 159 0.516
positive regulation of protein localization to nucleus GO:1900182 30 0.516
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.513
endocytosis GO:0006897 168 0.511
regulation of cell migration GO:0030334 219 0.511
regulation of cell division GO:0051302 76 0.510
positive regulation of cellular component biogenesis GO:0044089 94 0.508
Fly
regulation of t cell proliferation GO:0042129 92 0.505
maintenance of location in cell GO:0051651 24 0.504
protein catabolic process GO:0030163 221 0.497
Human Worm
regulation of cardiac cell fate specification GO:2000043 1 0.497
positive regulation of t cell differentiation GO:0045582 52 0.495
canonical wnt signaling pathway involved in positive regulation of apoptotic process GO:0044337 3 0.495
positive regulation of cell migration GO:0030335 109 0.495
nephron tubule development GO:0072080 84 0.494
cellular protein complex assembly GO:0043623 116 0.491
Human
regulation of innate immune response GO:0045088 91 0.490
smooth muscle tissue development GO:0048745 22 0.488
cell fate specification GO:0001708 72 0.488
actin filament organization GO:0007015 113 0.480
signal transduction by p53 class mediator GO:0072331 51 0.478
determination of heart left right asymmetry GO:0061371 48 0.477
Mouse
amide transport GO:0042886 138 0.477
Mouse
positive regulation of t cell activation GO:0050870 101 0.475
embryonic heart tube development GO:0035050 65 0.474
Mouse
regulation of response to wounding GO:1903034 189 0.472
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.469
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.468
covalent chromatin modification GO:0016569 163 0.467
positive regulation of nervous system development GO:0051962 221 0.467
Fly
regulation of body fluid levels GO:0050878 162 0.466
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.462
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.460
skeletal system development GO:0001501 356 0.459
Mouse
coagulation GO:0050817 78 0.457
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.451
regulation of cell cycle process GO:0010564 160 0.450
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.450
primary neural tube formation GO:0014020 95 0.449
peptide hormone secretion GO:0030072 109 0.449
Mouse
gonad morphogenesis GO:0035262 1 0.449
nucleocytoplasmic transport GO:0006913 139 0.447
mesonephric tubule morphogenesis GO:0072171 63 0.447
regulation of heart contraction GO:0008016 77 0.444
Mouse
positive regulation of tolerance induction GO:0002645 8 0.441
negative regulation of cellular protein metabolic process GO:0032269 247 0.440
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.438
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.435
stem cell fate specification GO:0048866 3 0.435
rig i signaling pathway GO:0039529 4 0.435
branching morphogenesis of an epithelial tube GO:0048754 159 0.433
protein autophosphorylation GO:0046777 61 0.433
extrinsic apoptotic signaling pathway GO:0097191 126 0.432
posttranscriptional gene silencing GO:0016441 10 0.432
heart contraction GO:0060047 93 0.431
Mouse
positive regulation of mesoderm development GO:2000382 2 0.431
nuclear import GO:0051170 95 0.427
positive regulation of b cell tolerance induction GO:0002663 2 0.420
cardiac ventricle development GO:0003231 83 0.419
Mouse
defense response to other organism GO:0098542 197 0.417
regulation of leukocyte differentiation GO:1902105 159 0.417
mesoderm development GO:0007498 100 0.416
neuron migration GO:0001764 122 0.415
limb morphogenesis GO:0035108 149 0.414
positive regulation of reproductive process GO:2000243 19 0.414
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.412
positive regulation of ras protein signal transduction GO:0046579 13 0.411
maternal determination of anterior posterior axis embryo GO:0008358 2 0.409
regulation of intracellular protein transport GO:0033157 82 0.408
endocardium development GO:0003157 10 0.408
regulation of protein binding GO:0043393 60 0.408
muscle tissue morphogenesis GO:0060415 53 0.408
Mouse
negative regulation of endothelial cell differentiation GO:0045602 2 0.407
intracellular protein transport GO:0006886 204 0.406
positive regulation of ossification GO:0045778 47 0.405
Mouse
regulation of wound healing GO:0061041 40 0.405
Mouse
segmentation GO:0035282 93 0.403
trachea formation GO:0060440 3 0.402
cytokine production GO:0001816 319 0.402
Human
central nervous system neuron differentiation GO:0021953 162 0.399
muscle cell proliferation GO:0033002 52 0.398
Mouse
macromolecule catabolic process GO:0009057 281 0.396
Human Worm
carbon catabolite activation of transcription GO:0045991 4 0.394
smad protein signal transduction GO:0060395 21 0.393
Human Mouse
negative regulation of wound healing GO:0061045 14 0.390
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.389
cardiac septum morphogenesis GO:0060411 46 0.388
Mouse
meiotic cell cycle GO:0051321 122 0.386
nuclear division GO:0000280 158 0.386
regulation of lymphocyte proliferation GO:0050670 117 0.385
positive regulation of rac protein signal transduction GO:0035022 1 0.385
cardiac septum development GO:0003279 59 0.385
regulation of cell activation GO:0050865 289 0.384
meiotic chromosome segregation GO:0045132 19 0.383
hemostasis GO:0007599 78 0.383
nitrogen compound transport GO:0071705 271 0.382
Mouse
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.381
morphogenesis of a branching structure GO:0001763 203 0.381
response to nutrient levels GO:0031667 109 0.380
retina vasculature development in camera type eye GO:0061298 17 0.380
cell matrix adhesion GO:0007160 68 0.378
regulation of t cell tolerance induction GO:0002664 6 0.375
mitotic cell cycle process GO:1903047 159 0.375
embryonic appendage morphogenesis GO:0035113 126 0.374
bronchus morphogenesis GO:0060434 2 0.373
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.373
regulation of heart morphogenesis GO:2000826 22 0.373
neural plate mediolateral regionalization GO:0021998 1 0.373
cellular response to abiotic stimulus GO:0071214 56 0.371
regulation of establishment of protein localization GO:0070201 181 0.370
positive regulation of growth GO:0045927 104 0.369
Worm Fly
nephron development GO:0072006 109 0.368
positive regulation of protein phosphorylation GO:0001934 242 0.368
outflow tract morphogenesis GO:0003151 53 0.367
protein import into nucleus GO:0006606 95 0.367
positive regulation of endothelial cell differentiation GO:0045603 7 0.366
negative regulation of phosphate metabolic process GO:0045936 184 0.364
Mouse
cellular senescence GO:0090398 11 0.364
regulation of meiotic cell cycle GO:0051445 34 0.362
organelle fission GO:0048285 170 0.358
regulation of reproductive process GO:2000241 66 0.358
proteoglycan biosynthetic process GO:0030166 20 0.356
regulation of cardiac muscle tissue development GO:0055024 31 0.356
b cell homeostasis GO:0001782 34 0.353
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.352
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.352
negative regulation of cell cycle process GO:0010948 69 0.350
intermediate filament based process GO:0045103 27 0.343
bone morphogenesis GO:0060349 78 0.343
heart valve development GO:0003170 23 0.342
regulation of system process GO:0044057 200 0.339
Mouse
regulation of b cell tolerance induction GO:0002661 2 0.338
positive regulation of cell death GO:0010942 224 0.338
renal system development GO:0072001 225 0.333
meiotic cell cycle process GO:1903046 77 0.332
regulation of cell aging GO:0090342 9 0.328
i kappab kinase nf kappab signaling GO:0007249 85 0.328
positive regulation of chemotaxis GO:0050921 38 0.328
regulation of cell motility GO:2000145 236 0.327
regulation of transferase activity GO:0051338 263 0.327
regulation of protein transport GO:0051223 163 0.327

Smad4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.993
Human
cancer DOID:162 0 0.888
Human
organ system cancer DOID:0050686 0 0.888
Human
gastrointestinal system cancer DOID:3119 0 0.501
intestinal cancer DOID:10155 0 0.501
large intestine cancer DOID:5672 0 0.452
colon cancer DOID:219 0 0.452
colorectal cancer DOID:9256 0 0.452