Mus musculus

21 known processes

Smad6

MAD homolog 6 (Drosophila)

(Aliases: Madh6)

Smad6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
bmp signaling pathway GO:0030509 93 1.000
Human Mouse Fly
mesenchyme development GO:0060485 152 0.999
Mouse
heart morphogenesis GO:0003007 178 0.998
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.996
Human Mouse Fly
regulation of tight junction assembly GO:2000810 2 0.996
renal system development GO:0072001 225 0.995
digestive tract development GO:0048565 190 0.995
Mouse Fly
urogenital system development GO:0001655 261 0.995
blood vessel morphogenesis GO:0048514 285 0.994
Mouse
kidney development GO:0001822 213 0.993
regulation of muscle tissue development GO:1901861 97 0.993
Mouse
digestive tract morphogenesis GO:0048546 147 0.993
Mouse Fly
cardiac septum development GO:0003279 59 0.993
Mouse
outflow tract morphogenesis GO:0003151 53 0.992
cellular response to growth factor stimulus GO:0071363 197 0.992
Human Mouse Fly
response to growth factor GO:0070848 198 0.992
Human Mouse Fly
negative regulation of bmp signaling pathway GO:0030514 35 0.991
Human Mouse
cardiac septum morphogenesis GO:0060411 46 0.990
Mouse
nephron morphogenesis GO:0072028 69 0.990
Mouse
ventricular septum development GO:0003281 42 0.988
Mouse
cardiac muscle tissue development GO:0048738 130 0.988
Mouse
ossification GO:0001503 216 0.988
Mouse
nephron tubule morphogenesis GO:0072078 68 0.987
Mouse
digestive system development GO:0055123 200 0.986
Mouse Fly
endocardial cushion development GO:0003197 26 0.986
Mouse
stem cell proliferation GO:0072089 117 0.985
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.984
Human Mouse Fly
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.984
Human Mouse Fly
cardiac chamber morphogenesis GO:0003206 93 0.983
Mouse
skeletal system morphogenesis GO:0048705 203 0.982
Mouse
cell junction assembly GO:0034329 52 0.982
atrioventricular valve morphogenesis GO:0003181 13 0.982
Mouse
cardiac chamber development GO:0003205 108 0.981
Mouse
camera type eye development GO:0043010 266 0.981
Mouse
stem cell maintenance GO:0019827 130 0.981
Fly
cardiocyte differentiation GO:0035051 87 0.979
Mouse
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.978
Mouse
ventricular septum morphogenesis GO:0060412 27 0.975
Mouse
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.973
Mouse
stem cell differentiation GO:0048863 268 0.971
Mouse Fly
regulation of organ morphogenesis GO:2000027 144 0.968
Mouse
stem cell development GO:0048864 219 0.968
Mouse Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.966
Human Mouse Fly
embryonic heart tube morphogenesis GO:0003143 51 0.966
Mouse
nephron development GO:0072006 109 0.965
Mouse
mapk cascade GO:0000165 281 0.965
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.963
Mouse
regulation of stem cell proliferation GO:0072091 78 0.961
muscle tissue development GO:0060537 308 0.961
Mouse
negative regulation of ossification GO:0030279 49 0.957
Mouse
muscle cell differentiation GO:0042692 261 0.952
regulation of ossification GO:0030278 112 0.949
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.949
cardiac ventricle development GO:0003231 83 0.948
Mouse
embryonic skeletal system development GO:0048706 120 0.947
Mouse
striated muscle tissue development GO:0014706 293 0.946
Mouse
wnt signaling pathway GO:0016055 188 0.944
osteoblast development GO:0002076 17 0.942
Mouse
regulation of cell activation GO:0050865 289 0.939
regulation of bmp signaling pathway GO:0030510 60 0.939
Human Mouse
neuron projection guidance GO:0097485 141 0.935
Mouse Fly
renal tubule morphogenesis GO:0061333 72 0.934
Mouse Fly
embryonic organ morphogenesis GO:0048562 276 0.934
Mouse
regulation of mapk cascade GO:0043408 248 0.933
chondrocyte differentiation GO:0002062 72 0.933
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.932
Mouse
regulation of cartilage development GO:0061035 44 0.932
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.929
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.928
epithelial cell proliferation GO:0050673 174 0.928
Mouse
epithelial tube morphogenesis GO:0060562 303 0.925
Mouse Fly
embryonic placenta development GO:0001892 98 0.922
respiratory system development GO:0060541 190 0.921
Mouse
determination of heart left right asymmetry GO:0061371 48 0.919
Mouse
regionalization GO:0003002 337 0.918
Human Mouse Fly
cardiac muscle tissue morphogenesis GO:0055008 44 0.918
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.917
Human Mouse Fly
ureteric bud development GO:0001657 94 0.917
retinal blood vessel morphogenesis GO:0061304 3 0.917
regulation of neuron differentiation GO:0045664 281 0.915
heart valve formation GO:0003188 10 0.914
Mouse
forebrain development GO:0030900 302 0.914
endocardial cell differentiation GO:0060956 4 0.913
Mouse
lung development GO:0030324 164 0.912
Mouse
mesoderm morphogenesis GO:0048332 64 0.912
Mouse
muscular septum morphogenesis GO:0003150 4 0.911
somite development GO:0061053 81 0.910
Mouse
nephron epithelium development GO:0072009 92 0.910
Mouse
ubiquitin dependent smad protein catabolic process GO:0030579 2 0.908
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.905
positive regulation of cell development GO:0010720 237 0.904
Mouse
positive regulation of nervous system development GO:0051962 221 0.904
hindbrain development GO:0030902 128 0.903
Mouse
axon guidance GO:0007411 141 0.902
Mouse Fly
cytoplasmic transport GO:0016482 234 0.901
Mouse
determination of left right symmetry GO:0007368 80 0.900
Mouse
endocrine system development GO:0035270 98 0.898
Mouse
negative regulation of cell proliferation GO:0008285 296 0.898
Human Mouse
heart valve morphogenesis GO:0003179 21 0.897
Mouse
regulation of vasculature development GO:1901342 88 0.893
epithelial tube formation GO:0072175 130 0.887
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.887
Human Fly
hormone secretion GO:0046879 128 0.886
Mouse
endodermal cell fate commitment GO:0001711 12 0.886
mitral valve development GO:0003174 4 0.886
morphogenesis of embryonic epithelium GO:0016331 159 0.885
hair follicle development GO:0001942 85 0.885
Mouse
axonogenesis GO:0007409 274 0.884
Mouse Fly
pigment accumulation GO:0043476 1 0.883
Worm
muscle cell development GO:0055001 133 0.881
circulatory system process GO:0003013 197 0.880
Mouse
mitral valve morphogenesis GO:0003183 4 0.880
negative regulation of fat cell differentiation GO:0045599 36 0.877
response to transforming growth factor beta GO:0071559 88 0.877
Human Mouse Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.876
respiratory tube development GO:0030323 167 0.874
Mouse
endocardial cushion morphogenesis GO:0003203 18 0.871
Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.871
Human Mouse Fly
canonical wnt signaling pathway GO:0060070 130 0.871
negative regulation of nervous system development GO:0051961 156 0.871
Fly
mesenchymal cell proliferation GO:0010463 44 0.870
angiogenesis GO:0001525 201 0.869
t cell activation GO:0042110 289 0.867
Mouse
nephron tubule development GO:0072080 84 0.866
Mouse
nephron epithelium morphogenesis GO:0072088 68 0.860
Mouse
limb morphogenesis GO:0035108 149 0.858
regulation of wnt signaling pathway GO:0030111 123 0.855
morphogenesis of an epithelial sheet GO:0002011 27 0.854
endodermal cell fate specification GO:0001714 4 0.849
epithelial to mesenchymal transition GO:0001837 47 0.846
Mouse
kidney epithelium development GO:0072073 121 0.842
heart formation GO:0060914 16 0.842
regulation of cell adhesion GO:0030155 154 0.842
Mouse
sensory organ morphogenesis GO:0090596 242 0.838
gland development GO:0048732 330 0.836
Mouse
regulation of cardiac muscle tissue development GO:0055024 31 0.833
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.832
neural tube formation GO:0001841 108 0.831
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.831
autonomic nervous system development GO:0048483 43 0.826
paraxial mesoderm morphogenesis GO:0048340 10 0.825
Mouse
embryonic digit morphogenesis GO:0042733 56 0.825
striated muscle cell development GO:0055002 125 0.824
axial mesoderm formation GO:0048320 3 0.823
blood circulation GO:0008015 195 0.823
Mouse
appendage morphogenesis GO:0035107 149 0.822
Fly
positive regulation of stem cell proliferation GO:2000648 59 0.819
regulation of osteoblast differentiation GO:0045667 67 0.819
Mouse
cell junction organization GO:0034330 77 0.818
mesonephric tubule development GO:0072164 94 0.818
artery development GO:0060840 53 0.816
Mouse
vascular endothelial growth factor receptor signaling pathway GO:0048010 24 0.815
nuclear transport GO:0051169 139 0.814
Mouse
lung morphogenesis GO:0060425 50 0.811
embryonic heart tube development GO:0035050 65 0.805
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.804
Mouse
gastrulation GO:0007369 116 0.803
Mouse
mesonephros development GO:0001823 97 0.803
morphogenesis of a branching structure GO:0001763 203 0.802
Mouse
jnk cascade GO:0007254 72 0.800
ureteric bud morphogenesis GO:0060675 62 0.795
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.792
mesodermal cell fate commitment GO:0001710 17 0.791
Mouse
negative regulation of cell development GO:0010721 169 0.790
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.788
embryonic limb morphogenesis GO:0030326 126 0.786
somatic stem cell maintenance GO:0035019 47 0.786
cardiac muscle cell differentiation GO:0055007 69 0.786
peptidyl amino acid modification GO:0018193 336 0.786
Mouse
regulation of neural precursor cell proliferation GO:2000177 70 0.783
bundle of his development GO:0003166 4 0.776
aorta morphogenesis GO:0035909 22 0.772
mesenchymal cell differentiation GO:0048762 107 0.770
Mouse
bone mineralization GO:0030282 54 0.770
organ growth GO:0035265 117 0.769
Mouse
neural tube closure GO:0001843 90 0.769
intracellular protein transport GO:0006886 204 0.768
Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.768
ventricular cardiac muscle tissue development GO:0003229 38 0.766
Mouse
renal tubule development GO:0061326 87 0.764
Mouse Fly
regulation of chondrocyte differentiation GO:0032330 33 0.763
Mouse
mesonephric tubule morphogenesis GO:0072171 63 0.759
Mouse
paraxial mesoderm development GO:0048339 18 0.748
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.748
Mouse
endothelial cell differentiation GO:0045446 41 0.747
Mouse
central nervous system neuron differentiation GO:0021953 162 0.743
regulation of neuron projection development GO:0010975 169 0.742
regulation of heart morphogenesis GO:2000826 22 0.741
Mouse
embryonic appendage morphogenesis GO:0035113 126 0.737
metanephric mesenchyme morphogenesis GO:0072133 4 0.737
Mouse
odontogenesis GO:0042476 78 0.736
telencephalon development GO:0021537 186 0.731
trachea cartilage morphogenesis GO:0060535 4 0.730
cell cell junction organization GO:0045216 72 0.727
cardiac ventricle morphogenesis GO:0003208 50 0.723
Mouse
heart valve development GO:0003170 23 0.723
Mouse
palate development GO:0060021 76 0.722
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.722
Fly
regulation of embryonic development GO:0045995 71 0.722
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.721
Human Mouse Fly
regulation of hippo signaling GO:0035330 1 0.721
kidney morphogenesis GO:0060993 83 0.720
Mouse
mesoderm formation GO:0001707 62 0.719
Mouse
tube formation GO:0035148 140 0.719
atrioventricular valve development GO:0003171 15 0.717
Mouse
regulation of mesenchymal cell proliferation GO:0010464 37 0.716
mesenchymal cell development GO:0014031 93 0.715
Mouse
metanephros development GO:0001656 79 0.715
Mouse
polarity specification of proximal distal axis GO:0010085 2 0.713
cardiac muscle cell development GO:0055013 39 0.711
cardiac endothelial cell differentiation GO:0003348 4 0.710
Mouse
cell proliferation involved in heart morphogenesis GO:0061323 15 0.709
Mouse
appendage development GO:0048736 166 0.706
Fly
aortic valve morphogenesis GO:0003180 4 0.705
cell cell signaling involved in cell fate commitment GO:0045168 35 0.704
mesenchyme morphogenesis GO:0072132 32 0.703
Mouse
protein localization to nucleus GO:0034504 121 0.703
Mouse
positive regulation of transferase activity GO:0051347 167 0.698
formation of primary germ layer GO:0001704 77 0.697
Mouse
erythrocyte differentiation GO:0030218 88 0.695
Mouse
cardiac atrium development GO:0003230 24 0.694
mesoderm development GO:0007498 100 0.692
Mouse
primary neural tube formation GO:0014020 95 0.688
cell fate specification GO:0001708 72 0.688
foregut morphogenesis GO:0007440 12 0.688
Mouse
neural crest cell differentiation GO:0014033 54 0.687
Mouse
single organismal cell cell adhesion GO:0016337 131 0.686
Mouse
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.686
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.682
single organism cell adhesion GO:0098602 156 0.679
Mouse
neural crest cell migration GO:0001755 32 0.678
segmentation GO:0035282 93 0.678
Mouse
placenta development GO:0001890 140 0.672
endocardial cushion formation GO:0003272 13 0.671
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.671
Mouse
regulation of jnk cascade GO:0046328 62 0.669
regulation of intracellular protein transport GO:0033157 82 0.669
Mouse
neural precursor cell proliferation GO:0061351 121 0.667
positive regulation of neuron differentiation GO:0045666 141 0.665
negative regulation of catenin import into nucleus GO:0035414 2 0.664
notochord development GO:0030903 20 0.663
single organism nuclear import GO:1902593 95 0.657
Mouse
syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 2 0.656
negative regulation of osteoblast differentiation GO:0045668 30 0.654
Mouse
myeloid cell differentiation GO:0030099 233 0.653
Mouse
regulation of lymphocyte activation GO:0051249 240 0.651
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.647
positive regulation of map kinase activity GO:0043406 84 0.645
regulation of epithelial to mesenchymal transition GO:0010717 22 0.644
Mouse
regulation of cell migration GO:0030334 219 0.643
cartilage development GO:0051216 140 0.642
Mouse
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.642
pituitary gland development GO:0021983 38 0.634
regulation of protein kinase activity GO:0045859 232 0.633
embryonic camera type eye development GO:0031076 36 0.633
kidney mesenchyme morphogenesis GO:0072131 4 0.632
Mouse
regulation of catenin import into nucleus GO:0035412 5 0.631
cardiac atrium morphogenesis GO:0003209 23 0.630
cell adhesion GO:0007155 329 0.629
Human Mouse
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.627
fat cell differentiation GO:0045444 160 0.623
Human
labyrinthine layer blood vessel development GO:0060716 21 0.623
retinal ganglion cell axon guidance GO:0031290 18 0.621
Fly
negative regulation of immune system process GO:0002683 209 0.620
notochord formation GO:0014028 5 0.619
positive regulation of stem cell differentiation GO:2000738 23 0.618
Mouse
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.618
myeloid cell homeostasis GO:0002262 114 0.617
Mouse
atrial septum primum morphogenesis GO:0003289 3 0.615
cell differentiation involved in embryonic placenta development GO:0060706 26 0.612
septum primum development GO:0003284 4 0.611
regulation of transferase activity GO:0051338 263 0.610
regulation of protein targeting GO:1903533 61 0.610
Mouse
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.610
regulation of cardiac muscle tissue growth GO:0055021 26 0.608
clara cell differentiation GO:0060486 4 0.606
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.599
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.598
forebrain regionalization GO:0021871 25 0.598
amine metabolic process GO:0009308 45 0.597
negative regulation of molecular function GO:0044092 258 0.595
limb development GO:0060173 166 0.594
negative regulation of wnt signaling pathway GO:0030178 73 0.588
embryonic digestive tract morphogenesis GO:0048557 17 0.588
neural tube development GO:0021915 160 0.586
midbrain development GO:0030901 35 0.586
Mouse
positive regulation of bmp signaling pathway GO:0030513 23 0.585
embryonic epithelial tube formation GO:0001838 130 0.584
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.583
skeletal system development GO:0001501 356 0.578
Mouse
leukocyte differentiation GO:0002521 342 0.574
forebrain neuron differentiation GO:0021879 52 0.573
stress activated mapk cascade GO:0051403 80 0.568
regulation of stress activated mapk cascade GO:0032872 69 0.566
blastocyst development GO:0001824 80 0.566
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.562
lens development in camera type eye GO:0002088 62 0.562
Mouse
cell fate determination GO:0001709 32 0.555
t cell proliferation GO:0042098 120 0.554
tricuspid valve development GO:0003175 3 0.554
cellular amino acid metabolic process GO:0006520 103 0.551
regulation of ureteric bud formation GO:0072106 3 0.551
developmental induction GO:0031128 34 0.550
peptidyl tyrosine phosphorylation GO:0018108 143 0.550
somitogenesis GO:0001756 69 0.549
Mouse
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.547
commissural neuron axon guidance GO:0071679 8 0.544
smad protein signal transduction GO:0060395 21 0.540
Mouse
regulation of map kinase activity GO:0043405 120 0.538
neuroblast proliferation GO:0007405 49 0.537
inner ear morphogenesis GO:0042472 101 0.537
regulation of osteoblast proliferation GO:0033688 15 0.536
Mouse
lymphocyte proliferation GO:0046651 164 0.536
regulation of cell cycle GO:0051726 281 0.532
cardiac muscle tissue growth GO:0055017 37 0.532
Mouse
cardiac epithelial to mesenchymal transition GO:0060317 18 0.531
Mouse
muscle system process GO:0003012 141 0.530
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.530
positive regulation of cardiac muscle tissue development GO:0055025 19 0.529
connective tissue development GO:0061448 179 0.525
Mouse
cardiac muscle cell proliferation GO:0060038 31 0.524
Mouse
nephric duct formation GO:0072179 4 0.524
progesterone secretion GO:0042701 1 0.523
positive regulation of epithelial cell proliferation GO:0050679 68 0.523
paraxial mesodermal cell differentiation GO:0048342 2 0.521
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.519
Mouse
striated muscle cell proliferation GO:0014855 39 0.519
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.518
Human Fly
regulation of cell substrate adhesion GO:0010810 73 0.518
mesonephric epithelium development GO:0072163 94 0.513
pancreas development GO:0031016 57 0.513
Mouse
regulation of t cell proliferation GO:0042129 92 0.510
insulin secretion GO:0030073 89 0.509
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.508
skeletal muscle fiber development GO:0048741 58 0.506
cardiac right atrium morphogenesis GO:0003213 3 0.504
myoblast differentiation GO:0045445 52 0.500
somite rostral caudal axis specification GO:0032525 13 0.498
Mouse
his purkinje system development GO:0003164 4 0.497
positive regulation of heart growth GO:0060421 18 0.495
ear development GO:0043583 200 0.494
regulation of striated muscle cell differentiation GO:0051153 81 0.493
central nervous system vasculogenesis GO:0022009 3 0.493
positive regulation of protein modification process GO:0031401 299 0.492
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.490
chemotaxis GO:0006935 247 0.485
Mouse Fly
positive regulation of ureteric bud formation GO:0072107 3 0.485
positive regulation of striated muscle tissue development GO:0045844 31 0.485
metencephalon development GO:0022037 89 0.484
positive regulation of angiogenesis GO:0045766 46 0.481
apical junction assembly GO:0043297 15 0.480
cell fate commitment GO:0045165 210 0.477
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.476
biomineral tissue development GO:0031214 64 0.476
positive regulation of protein kinase activity GO:0045860 144 0.475
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.474
epithelial cell morphogenesis GO:0003382 41 0.473
retina vasculature development in camera type eye GO:0061298 17 0.471
forebrain neuron fate commitment GO:0021877 13 0.470
negative regulation of prostatic bud formation GO:0060686 4 0.469
positive regulation of cartilage development GO:0061036 18 0.467
Mouse
ear morphogenesis GO:0042471 118 0.466
forebrain morphogenesis GO:0048853 17 0.466
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.465
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.463
Mouse
regulation of gliogenesis GO:0014013 50 0.463
negative regulation of cell fate specification GO:0009996 4 0.460
negative regulation of hepatocyte differentiation GO:0070367 1 0.459
renal vesicle induction GO:0072034 3 0.459
smoothened signaling pathway GO:0007224 105 0.458
mammary gland morphogenesis GO:0060443 54 0.458
gonad development GO:0008406 141 0.452
neural crest cell development GO:0014032 48 0.451
labyrinthine layer development GO:0060711 49 0.451
cell migration involved in gastrulation GO:0042074 13 0.450
specification of organ identity GO:0010092 30 0.449
aorta development GO:0035904 23 0.448
positive regulation of cell adhesion GO:0045785 80 0.447
Mouse
cochlea morphogenesis GO:0090103 22 0.446
positive regulation of protein catabolic process GO:0045732 60 0.441
gastrulation with mouth forming second GO:0001702 29 0.441
Mouse
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.440
lymphocyte differentiation GO:0030098 242 0.440
axial mesoderm morphogenesis GO:0048319 5 0.440
protein modification by small protein conjugation GO:0032446 187 0.439
positive regulation of jun kinase activity GO:0043507 30 0.438
response to monosaccharide GO:0034284 67 0.437
Mouse
cochlea development GO:0090102 35 0.433
regulation of angiogenesis GO:0045765 81 0.432
regulation of fat cell differentiation GO:0045598 81 0.428
ameboidal type cell migration GO:0001667 128 0.428
sympathetic nervous system development GO:0048485 22 0.427
regulation of cardiac cell fate specification GO:2000043 1 0.426
planar cell polarity pathway involved in neural tube closure GO:0090179 14 0.426
regulation of leukocyte proliferation GO:0070663 121 0.425
nephrogenic mesenchyme development GO:0072076 3 0.425
Mouse
epidermis development GO:0008544 187 0.419
Mouse
regulation of t cell activation GO:0050863 170 0.417
mesendoderm development GO:0048382 3 0.417
blastocyst formation GO:0001825 33 0.416
spinal cord development GO:0021510 81 0.416
skeletal muscle organ development GO:0060538 163 0.416
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.413
negative regulation of growth GO:0045926 99 0.412
Fly
regulation of peptide hormone secretion GO:0090276 75 0.412
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.411
regulation of binding GO:0051098 111 0.409
Mouse
epithelial cell development GO:0002064 159 0.408
mammary placode formation GO:0060596 4 0.403
regulation of stem cell differentiation GO:2000736 50 0.402
Mouse
retina development in camera type eye GO:0060041 119 0.400
protein import into nucleus GO:0006606 95 0.399
Mouse
negative regulation of defense response GO:0031348 77 0.398
Mouse
endothelium development GO:0003158 45 0.396
Mouse
positive regulation of chondrocyte differentiation GO:0032332 13 0.396
Mouse
bone development GO:0060348 120 0.396
Mouse
tongue development GO:0043586 18 0.396
tendon formation GO:0035992 4 0.395
regulation of cardiac chamber morphogenesis GO:1901219 2 0.394
peptide transport GO:0015833 133 0.394
Mouse
regulation of kidney development GO:0090183 40 0.390
limbic system development GO:0021761 72 0.389
endoderm formation GO:0001706 20 0.388
Mouse
endochondral bone morphogenesis GO:0060350 50 0.388
regulation of chorionic trophoblast cell proliferation GO:1901382 1 0.386
embryonic eye morphogenesis GO:0048048 29 0.385
regulation of establishment of planar polarity GO:0090175 28 0.385
odontogenesis of dentin containing tooth GO:0042475 66 0.383
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.383
Mouse
cerebellum vasculature development GO:0061300 1 0.382
formation of radial glial scaffolds GO:0021943 4 0.378
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 14 0.375
bone morphogenesis GO:0060349 78 0.373
neural tube patterning GO:0021532 43 0.372
tube closure GO:0060606 91 0.369
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.369
Mouse
negative regulation of phosphorylation GO:0042326 166 0.369
Human Mouse
hepaticobiliary system development GO:0061008 67 0.367
Mouse
cell differentiation involved in kidney development GO:0061005 33 0.366
embryonic nail plate morphogenesis GO:0035880 3 0.365
regulation of cellular amino acid metabolic process GO:0006521 5 0.364
nucleocytoplasmic transport GO:0006913 139 0.363
Mouse
positive regulation of neuroblast proliferation GO:0002052 19 0.363
leukocyte proliferation GO:0070661 172 0.362
myeloid leukocyte differentiation GO:0002573 119 0.362
liver development GO:0001889 66 0.362
Mouse
cerebellum vasculature morphogenesis GO:0061301 1 0.361
regulation of heart growth GO:0060420 31 0.360
forebrain generation of neurons GO:0021872 63 0.360
epithelial cell differentiation involved in kidney development GO:0035850 23 0.359
cerebral cortex development GO:0021987 86 0.359
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.357
Mouse
heart trabecula formation GO:0060347 14 0.357
negative regulation of embryonic development GO:0045992 22 0.356
positive regulation of mapk cascade GO:0043410 170 0.355
establishment of planar polarity of embryonic epithelium GO:0042249 16 0.354
cellular ketone metabolic process GO:0042180 84 0.352
body morphogenesis GO:0010171 45 0.350
regulation of kinase activity GO:0043549 249 0.350
metanephric nephron development GO:0072210 34 0.350
regulation of lymphocyte proliferation GO:0050670 117 0.348
skeletal muscle cell differentiation GO:0035914 66 0.348
regulation of protein catabolic process GO:0042176 108 0.346
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.344
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.344
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.343
oligodendrocyte differentiation GO:0048709 53 0.343
protein import GO:0017038 101 0.341
Mouse
cardiac cell development GO:0055006 41 0.339
organ induction GO:0001759 21 0.337
metanephric nephron epithelium development GO:0072243 19 0.337
coronary vasculature development GO:0060976 12 0.332
chondrocyte development GO:0002063 24 0.331
olfactory lobe development GO:0021988 32 0.330
cell cell junction assembly GO:0007043 27 0.327
renal vesicle development GO:0072087 17 0.327
negative regulation of execution phase of apoptosis GO:1900118 4 0.327
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.326
heart growth GO:0060419 45 0.324
Mouse
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.324
atrioventricular canal development GO:0036302 5 0.323
Mouse
positive regulation of muscle tissue development GO:1901863 32 0.323
peptide hormone secretion GO:0030072 109 0.323
Mouse
immune effector process GO:0002252 321 0.323
axis elongation involved in somitogenesis GO:0090245 4 0.322
metanephric tubule development GO:0072170 18 0.321
regulation of nucleocytoplasmic transport GO:0046822 73 0.321
Mouse
embryonic digestive tract development GO:0048566 27 0.320
skeletal muscle tissue regeneration GO:0043403 20 0.319
epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 4 0.316
maintenance of cell number GO:0098727 3 0.316
atrial septum development GO:0003283 12 0.315
muscle contraction GO:0006936 101 0.313
Mouse
negative regulation of cartilage development GO:0061037 17 0.313
glial cell differentiation GO:0010001 131 0.311
positive regulation of ossification GO:0045778 47 0.310
Mouse

Smad6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.530
cancer DOID:162 0 0.382
organ system cancer DOID:0050686 0 0.382