|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.984
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.965
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.965
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.961
|
|
|
|
heart morphogenesis
|
GO:0003007 |
178 |
0.940
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.919
|
Mouse Fly |
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.915
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.911
|
Mouse Fly |
|
|
negative regulation of cellular response to growth factor stimulus
|
GO:0090288 |
46 |
0.908
|
Human Fly |
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.908
|
Human |
|
|
pigment accumulation
|
GO:0043476 |
1 |
0.903
|
Worm |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.898
|
Human |
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.892
|
Mouse |
|
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030512 |
26 |
0.888
|
Human Fly |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.886
|
|
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
35 |
0.853
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.851
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
43 |
0.850
|
Human Mouse Fly |
|
|
stem cell differentiation
|
GO:0048863 |
268 |
0.847
|
Mouse Fly |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.841
|
|
|
|
negative regulation of peptidyl serine phosphorylation
|
GO:0033137 |
10 |
0.835
|
|
|
|
chondrocyte development
|
GO:0002063 |
24 |
0.823
|
|
|
|
negative regulation of osteoblast differentiation
|
GO:0045668 |
30 |
0.820
|
Mouse |
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.817
|
Mouse |
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
60 |
0.804
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.785
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
77 |
0.779
|
Mouse |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.778
|
Human |
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.765
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.765
|
Mouse |
|
|
regulation of chondrocyte differentiation
|
GO:0032330 |
33 |
0.757
|
Mouse |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.755
|
Mouse Fly |
|
|
respiratory system development
|
GO:0060541 |
190 |
0.754
|
Mouse |
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.751
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.734
|
Mouse |
|
|
stem cell development
|
GO:0048864 |
219 |
0.734
|
Mouse Fly |
|
|
mapk cascade
|
GO:0000165 |
281 |
0.726
|
Mouse |
|
|
digestive system development
|
GO:0055123 |
200 |
0.724
|
Mouse Fly |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.716
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.713
|
|
|
|
negative regulation of ossification
|
GO:0030279 |
49 |
0.692
|
Mouse |
|
|
retinal ganglion cell axon guidance
|
GO:0031290 |
18 |
0.691
|
Fly |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.689
|
Human |
|
|
regulation of cartilage development
|
GO:0061035 |
44 |
0.685
|
Mouse |
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.684
|
Mouse |
|
|
stem cell maintenance
|
GO:0019827 |
130 |
0.684
|
Fly |
|
|
chondrocyte differentiation
|
GO:0002062 |
72 |
0.681
|
Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.679
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.671
|
Mouse |
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.668
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.663
|
|
|
|
mesenchyme development
|
GO:0060485 |
152 |
0.654
|
Mouse |
|
|
regulation of ossification
|
GO:0030278 |
112 |
0.646
|
Mouse |
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.645
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.643
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.643
|
Mouse Fly |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.637
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
93 |
0.634
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.631
|
|
|
|
bone development
|
GO:0060348 |
120 |
0.624
|
Mouse |
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
34 |
0.623
|
Human |
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
61 |
0.621
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.618
|
Human |
|
|
muscle cell development
|
GO:0055001 |
133 |
0.614
|
|
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
23 |
0.599
|
Human |
|
|
ossification
|
GO:0001503 |
216 |
0.591
|
Mouse |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.590
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.589
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.587
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.568
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.559
|
Human |
|
|
bone morphogenesis
|
GO:0060349 |
78 |
0.558
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.549
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.546
|
Mouse |
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.542
|
Human Mouse Fly |
|
|
gastrulation
|
GO:0007369 |
116 |
0.530
|
Mouse |
|
|
palate development
|
GO:0060021 |
76 |
0.528
|
Mouse |
|
|
positive regulation of stem cell differentiation
|
GO:2000738 |
23 |
0.526
|
Mouse |
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.525
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.518
|
Mouse |
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
25 |
0.514
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.513
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.510
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
43 |
0.506
|
Mouse |
|
|
endothelial cell differentiation
|
GO:0045446 |
41 |
0.504
|
Mouse |
|
|
mesoderm development
|
GO:0007498 |
100 |
0.501
|
Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.495
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.493
|
Fly |
|
|
negative regulation of fat cell differentiation
|
GO:0045599 |
36 |
0.484
|
|
|
|
stem cell proliferation
|
GO:0072089 |
117 |
0.482
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.480
|
|
|
|
respiratory tube development
|
GO:0030323 |
167 |
0.479
|
Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.477
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.477
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.470
|
Human |
|
|
cartilage development
|
GO:0051216 |
140 |
0.466
|
Mouse |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.466
|
Human |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.458
|
Fly |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.456
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.455
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
47 |
0.454
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.449
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
88 |
0.446
|
Mouse |
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.441
|
Mouse |
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.434
|
Human |
|
|
nephrogenic mesenchyme development
|
GO:0072076 |
3 |
0.433
|
Mouse |
|
|
endocardial cell differentiation
|
GO:0060956 |
4 |
0.431
|
Mouse |
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
138 |
0.426
|
Fly |
|
|
skeletal system morphogenesis
|
GO:0048705 |
203 |
0.426
|
Mouse |
|
|
endochondral bone morphogenesis
|
GO:0060350 |
50 |
0.425
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.424
|
Human |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.423
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
50 |
0.421
|
Mouse |
|
|
smad protein signal transduction
|
GO:0060395 |
21 |
0.421
|
Mouse |
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.416
|
|
|
|
regulation of cardiac cell fate specification
|
GO:2000043 |
1 |
0.415
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.414
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.414
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.414
|
Mouse |
|
|
skin development
|
GO:0043588 |
220 |
0.410
|
Mouse |
|
|
axonogenesis
|
GO:0007409 |
274 |
0.409
|
Mouse Fly |
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.409
|
|
|
|
heart formation
|
GO:0060914 |
16 |
0.408
|
|
|
|
determination of left right symmetry
|
GO:0007368 |
80 |
0.405
|
Mouse |
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.404
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.402
|
Mouse |
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.398
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.397
|
Human |
|
|
gonad development
|
GO:0008406 |
141 |
0.397
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.394
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.393
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.391
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.386
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.385
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.382
|
Mouse Fly |
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.380
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.376
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
143 |
0.373
|
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.372
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.363
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.361
|
Mouse |
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.360
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.355
|
Mouse |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.355
|
|
|
|
renal system development
|
GO:0072001 |
225 |
0.353
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.347
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
31 |
0.346
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.343
|
|
|
|
cartilage development involved in endochondral bone morphogenesis
|
GO:0060351 |
24 |
0.340
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.338
|
|
|
|
cardiac endothelial cell differentiation
|
GO:0003348 |
4 |
0.337
|
Mouse |
|
|
regulation of catenin import into nucleus
|
GO:0035412 |
5 |
0.333
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.332
|
Mouse Fly |
|
|
mesoderm morphogenesis
|
GO:0048332 |
64 |
0.331
|
Mouse |
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.330
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.329
|
|
|
|
regulation of fat cell differentiation
|
GO:0045598 |
81 |
0.328
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.326
|
Mouse |
|
|
endothelium development
|
GO:0003158 |
45 |
0.324
|
Mouse |
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.322
|
Mouse |
|
|
blastocyst development
|
GO:0001824 |
80 |
0.320
|
|
|
|
organ growth
|
GO:0035265 |
117 |
0.320
|
Mouse |
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.315
|
Human |
|
|
heart contraction
|
GO:0060047 |
93 |
0.314
|
|
|
|
negative regulation of cell fate specification
|
GO:0009996 |
4 |
0.314
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.313
|
Mouse Fly |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.313
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.312
|
|
|
|
neural tube formation
|
GO:0001841 |
108 |
0.311
|
|
|
|
bone mineralization
|
GO:0030282 |
54 |
0.311
|
|
|
|
kidney mesenchyme morphogenesis
|
GO:0072131 |
4 |
0.309
|
Mouse |
|
|
wound healing
|
GO:0042060 |
157 |
0.306
|
Mouse |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.304
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.301
|
Human |
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
67 |
0.299
|
Mouse |
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.299
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.298
|
|
|
|
outflow tract morphogenesis
|
GO:0003151 |
53 |
0.298
|
|
|
|
positive regulation of epithelial to mesenchymal transition
|
GO:0010718 |
13 |
0.296
|
Mouse |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.295
|
Human Mouse |
|
|
heart field specification
|
GO:0003128 |
6 |
0.291
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
51 |
0.287
|
Mouse |
|
|
cell cell signaling involved in cell fate commitment
|
GO:0045168 |
35 |
0.285
|
|
|
|
wnt signaling pathway involved in somitogenesis
|
GO:0090244 |
4 |
0.285
|
|
|
|
negative regulation of peptidyl threonine phosphorylation
|
GO:0010801 |
6 |
0.284
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.281
|
|
|
|
osteoblast development
|
GO:0002076 |
17 |
0.278
|
Mouse |
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.277
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.277
|
|
|
|
regulation of cell fate commitment
|
GO:0010453 |
19 |
0.276
|
|
|
|
axial mesoderm formation
|
GO:0048320 |
3 |
0.272
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
72 |
0.270
|
Mouse |
|
|
positive regulation of cell proliferation involved in heart valve morphogenesis
|
GO:0003251 |
1 |
0.270
|
Mouse |
|
|
blood circulation
|
GO:0008015 |
195 |
0.269
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.268
|
Mouse |
|
|
connective tissue development
|
GO:0061448 |
179 |
0.268
|
Mouse |
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.267
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.266
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.264
|
Mouse |
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.264
|
Mouse |
|
|
specification of organ identity
|
GO:0010092 |
30 |
0.264
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.263
|
|
|
|
metanephric mesenchyme morphogenesis
|
GO:0072133 |
4 |
0.261
|
Mouse |
|
|
cell fate specification
|
GO:0001708 |
72 |
0.258
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.257
|
|
|
|
camera type eye development
|
GO:0043010 |
266 |
0.255
|
Mouse |
|
|
cardiac muscle tissue development
|
GO:0048738 |
130 |
0.253
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.253
|
Mouse |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
56 |
0.252
|
Human |
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.252
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.252
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus
|
GO:1901522 |
7 |
0.251
|
Mouse |
|
|
negative regulation of osteoblast proliferation
|
GO:0033689 |
4 |
0.250
|
Mouse |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.247
|
Human |
|
|
biomineral tissue development
|
GO:0031214 |
64 |
0.247
|
|
|
|
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000060 |
8 |
0.246
|
|
|
|
mesenchymal cell proliferation
|
GO:0010463 |
44 |
0.245
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.240
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.238
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
169 |
0.238
|
|
|
|
sensory perception of sound
|
GO:0007605 |
97 |
0.237
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.236
|
Human |
|
|
negative regulation of neuron differentiation
|
GO:0045665 |
101 |
0.233
|
|
|
|
kidney development
|
GO:0001822 |
213 |
0.232
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.231
|
Human |
|
|
regulation of blood circulation
|
GO:1903522 |
93 |
0.230
|
|
|
|
striated muscle cell development
|
GO:0055002 |
125 |
0.227
|
|
|
|
mesoderm formation
|
GO:0001707 |
62 |
0.225
|
Mouse |
|
|
tube formation
|
GO:0035148 |
140 |
0.223
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.222
|
Mouse |
|
|
pallium development
|
GO:0021543 |
120 |
0.220
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.220
|
Fly |
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
107 |
0.219
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.214
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
81 |
0.214
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.212
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.212
|
Mouse |
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.211
|
|
|
|
forebrain cell migration
|
GO:0021885 |
58 |
0.209
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.205
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
95 |
0.202
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.202
|
|
|
|
ubiquitin dependent smad protein catabolic process
|
GO:0030579 |
2 |
0.201
|
|
|
|
hindbrain development
|
GO:0030902 |
128 |
0.201
|
Mouse |
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.201
|
Mouse |
|
|
embryonic heart tube development
|
GO:0035050 |
65 |
0.199
|
Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.199
|
|
|
|
regulation of cardioblast differentiation
|
GO:0051890 |
3 |
0.199
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.198
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
31 |
0.197
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.197
|
|
|
|
negative regulation of dna templated transcription elongation
|
GO:0032785 |
6 |
0.196
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.196
|
Mouse |
|
|
cell proliferation involved in heart valve development
|
GO:2000793 |
2 |
0.195
|
Mouse |
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.194
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.193
|
|
|
|
nephrogenic mesenchyme morphogenesis
|
GO:0072134 |
2 |
0.192
|
Mouse |
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.192
|
|
|
|
regulation of blood pressure
|
GO:0008217 |
93 |
0.191
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
49 |
0.191
|
|
|
|
regulation of cell fate specification
|
GO:0042659 |
10 |
0.188
|
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.187
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.184
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.183
|
|
|
|
activin receptor signaling pathway
|
GO:0032924 |
18 |
0.182
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.180
|
|
|
|
circulatory system process
|
GO:0003013 |
197 |
0.180
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.179
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.178
|
Mouse |
|
|
positive regulation of ubiquitin protein transferase activity
|
GO:0051443 |
4 |
0.178
|
|
|
|
metanephros development
|
GO:0001656 |
79 |
0.178
|
Mouse |
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.176
|
Mouse |
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.176
|
Human |
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
27 |
0.175
|
Human |
|
|
telencephalon development
|
GO:0021537 |
186 |
0.174
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.174
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.174
|
|
|
|
ventricular septum development
|
GO:0003281 |
42 |
0.172
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.171
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
1 |
0.170
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.170
|
Human |
|
|
lens development in camera type eye
|
GO:0002088 |
62 |
0.170
|
Mouse |
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
38 |
0.169
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.169
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.168
|
|
|
|
regulation of muscle tissue development
|
GO:1901861 |
97 |
0.167
|
Mouse |
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.167
|
|
|
|
central nervous system neuron differentiation
|
GO:0021953 |
162 |
0.166
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.166
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
87 |
0.165
|
Mouse |
|
|
negative regulation of pathway restricted smad protein phosphorylation
|
GO:0060394 |
1 |
0.164
|
Human |
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.164
|
|
|
|
appendage development
|
GO:0048736 |
166 |
0.162
|
Fly |
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
10 |
0.160
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
31 |
0.160
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.160
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.159
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.159
|
Mouse |
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.159
|
Fly |
|
|
cardiac cell fate specification
|
GO:0060912 |
2 |
0.158
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.158
|
Mouse |
|
|
cell proliferation involved in heart valve morphogenesis
|
GO:0003249 |
1 |
0.158
|
Mouse |
|
|
endocardial cushion morphogenesis
|
GO:0003203 |
18 |
0.158
|
Mouse |
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.158
|
|
|
|
embryonic skeletal system morphogenesis
|
GO:0048704 |
91 |
0.157
|
Mouse |
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.157
|
|
|
|
positive regulation of transcription elongation from rna polymerase ii promoter
|
GO:0032968 |
2 |
0.157
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.156
|
|
|
|
embryonic limb morphogenesis
|
GO:0030326 |
126 |
0.155
|
|
|
|
mammary gland morphogenesis
|
GO:0060443 |
54 |
0.155
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.153
|
Mouse |
|
|
heart growth
|
GO:0060419 |
45 |
0.153
|
Mouse |
|
|
regulation of muscle system process
|
GO:0090257 |
80 |
0.151
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.151
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
47 |
0.151
|
Mouse |
|
|
regulation of heart contraction
|
GO:0008016 |
77 |
0.150
|
|
|
|
skeletal muscle fiber development
|
GO:0048741 |
58 |
0.150
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.149
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.148
|
Mouse |
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
22 |
0.148
|
Mouse |
|
|
positive regulation of dna templated transcription elongation
|
GO:0032786 |
2 |
0.148
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.148
|
|
|
|
regulation of lymphocyte anergy
|
GO:0002911 |
4 |
0.147
|
|
|
|
cardiac ventricle development
|
GO:0003231 |
83 |
0.147
|
|
|
|
cell recognition
|
GO:0008037 |
83 |
0.147
|
|
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
193 |
0.147
|
Mouse |
|
|
cell cell junction organization
|
GO:0045216 |
72 |
0.146
|
Human |
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.146
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
130 |
0.145
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.145
|
Mouse |
|
|
ear morphogenesis
|
GO:0042471 |
118 |
0.145
|
|
|
|
developmental cell growth
|
GO:0048588 |
84 |
0.144
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
10 |
0.144
|
Human |
|
|
t cell activation
|
GO:0042110 |
289 |
0.143
|
Mouse |
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
40 |
0.143
|
Human |
|
|
positive regulation of t cell anergy
|
GO:0002669 |
4 |
0.143
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.142
|
Fly |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.142
|
|
|
|
metencephalon development
|
GO:0022037 |
89 |
0.142
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.141
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.139
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
88 |
0.138
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.138
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.138
|
|
|
|
embryonic skeletal system development
|
GO:0048706 |
120 |
0.136
|
Mouse |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.135
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
83 |
0.134
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.134
|
Mouse |
|
|
cardiac chamber development
|
GO:0003205 |
108 |
0.133
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.131
|
Mouse |
|
|
cell fate commitment involved in formation of primary germ layer
|
GO:0060795 |
26 |
0.131
|
Mouse |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.131
|
|
|
|
endocrine system development
|
GO:0035270 |
98 |
0.131
|
Mouse |
|
|
female gamete generation
|
GO:0007292 |
74 |
0.129
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.129
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.128
|
|
|
|
regulation of endothelial cell differentiation
|
GO:0045601 |
10 |
0.128
|
|
|
|
epithelial cell migration
|
GO:0010631 |
63 |
0.127
|
|
|
|
macromolecule deacylation
|
GO:0098732 |
37 |
0.127
|
|
|
|
muscle fiber development
|
GO:0048747 |
76 |
0.126
|
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.125
|
Mouse |
|
|
cerebral cortex cell migration
|
GO:0021795 |
44 |
0.124
|
|
|
|
cardiac septum development
|
GO:0003279 |
59 |
0.123
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.123
|
Human |
|
|
somite development
|
GO:0061053 |
81 |
0.123
|
Mouse |
|
|
regulation of t cell anergy
|
GO:0002667 |
4 |
0.123
|
|
|
|
response to fluid shear stress
|
GO:0034405 |
7 |
0.123
|
Human |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.122
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
70 |
0.122
|
|
|
|
neuron migration
|
GO:0001764 |
122 |
0.121
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
68 |
0.120
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.120
|
|
|
|
regulation of mesenchymal cell proliferation
|
GO:0010464 |
37 |
0.120
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
101 |
0.119
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
82 |
0.118
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.118
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
13 |
0.117
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
116 |
0.117
|
|
|
|
cardiac muscle tissue morphogenesis
|
GO:0055008 |
44 |
0.116
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.116
|
Mouse |
|
|
organelle localization
|
GO:0051640 |
179 |
0.116
|
|
|
|
regulation of stem cell proliferation
|
GO:0072091 |
78 |
0.116
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.115
|
|
|
|
cell aging
|
GO:0007569 |
35 |
0.115
|
|
|
|
neural precursor cell proliferation
|
GO:0061351 |
121 |
0.114
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.114
|
|
|
|
secondary heart field specification
|
GO:0003139 |
6 |
0.114
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.113
|
|
|
|
development of primary female sexual characteristics
|
GO:0046545 |
73 |
0.113
|
|
|
|
positive regulation of lymphocyte anergy
|
GO:0002913 |
4 |
0.112
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
12 |
0.111
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.111
|
Mouse |
|
|
ameboidal type cell migration
|
GO:0001667 |
128 |
0.111
|
|
|
|
positive regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030511 |
12 |
0.110
|
|
|
|
genetic imprinting
|
GO:0071514 |
27 |
0.110
|
|
|
|
regulation of cell projection assembly
|
GO:0060491 |
38 |
0.110
|
|
|
|
skeletal muscle organ development
|
GO:0060538 |
163 |
0.110
|
|
|
|
renal tubule development
|
GO:0061326 |
87 |
0.109
|
Mouse Fly |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.109
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.108
|
Human |
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.108
|
|
|
|
cytoplasmic microtubule organization
|
GO:0031122 |
14 |
0.108
|
|
|
|
muscle contraction
|
GO:0006936 |
101 |
0.107
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.106
|
|
|
|
hormone secretion
|
GO:0046879 |
128 |
0.106
|
Mouse |
|
|
extracellular matrix organization
|
GO:0030198 |
147 |
0.105
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.105
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.104
|
|
|
|
negative regulation of systemic arterial blood pressure
|
GO:0003085 |
15 |
0.104
|
|
|
|
cardiac muscle contraction
|
GO:0060048 |
32 |
0.104
|
|
|
|
synapse assembly
|
GO:0007416 |
56 |
0.103
|
Fly |
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.103
|
|
|
|
cell junction assembly
|
GO:0034329 |
52 |
0.103
|
Human |
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.103
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.103
|
Human |
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
119 |
0.103
|
|
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.102
|
Fly |
|
|
tissue homeostasis
|
GO:0001894 |
115 |
0.101
|
|
|
|
cerebral cortex development
|
GO:0021987 |
86 |
0.101
|
|
|
|
female sex differentiation
|
GO:0046660 |
84 |
0.100
|
|
|
|
synaptic growth at neuromuscular junction
|
GO:0051124 |
6 |
0.100
|
Fly |
|
|
regulation of cell growth
|
GO:0001558 |
91 |
0.100
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.100
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
14 |
0.100
|
|
|
|
neuroepithelial cell differentiation
|
GO:0060563 |
37 |
0.100
|
|
|
|
genitalia development
|
GO:0048806 |
37 |
0.100
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.099
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.099
|
|
|
|
mesendoderm development
|
GO:0048382 |
3 |
0.098
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.098
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.097
|
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.096
|
Mouse |
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.096
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.096
|
|
|
|
epithelial to mesenchymal transition involved in endocardial cushion formation
|
GO:0003198 |
10 |
0.096
|
Mouse |
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.096
|
|
|
|
multi multicellular organism process
|
GO:0044706 |
109 |
0.096
|
Worm |
|
|
multi organism behavior
|
GO:0051705 |
62 |
0.095
|
Worm |
|
|
regulation of hormone levels
|
GO:0010817 |
211 |
0.095
|
Mouse |
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.094
|
Mouse |
|
|
sensory perception
|
GO:0007600 |
245 |
0.094
|
|
|
|
positive regulation of stem cell proliferation
|
GO:2000648 |
59 |
0.094
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.093
|
|
|
|
auditory receptor cell differentiation
|
GO:0042491 |
37 |
0.093
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.092
|
Mouse |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.092
|
|
|
|
germ line stem cell division
|
GO:0042078 |
2 |
0.091
|
|
|
|
endocardial cushion development
|
GO:0003197 |
26 |
0.091
|
Mouse |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.091
|
Mouse |
|
|
amide transport
|
GO:0042886 |
138 |
0.091
|
Mouse |
|
|
histone modification
|
GO:0016570 |
159 |
0.089
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.089
|
Human |
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.089
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.089
|
|
|
|
endocardium development
|
GO:0003157 |
10 |
0.089
|
Mouse |
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.089
|
|
|
|
embryonic skeletal joint development
|
GO:0072498 |
13 |
0.089
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.088
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.088
|
Mouse |
|
|
blastocyst formation
|
GO:0001825 |
33 |
0.088
|
|
|
|
positive regulation of bmp signaling pathway
|
GO:0030513 |
23 |
0.088
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.088
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.088
|
|
|
|
regulation of wound healing
|
GO:0061041 |
40 |
0.086
|
Mouse |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.086
|
|
|
|
cardiac septum morphogenesis
|
GO:0060411 |
46 |
0.085
|
|
|
|
cell fate determination
|
GO:0001709 |
32 |
0.085
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.085
|
|
|
|
adult behavior
|
GO:0030534 |
135 |
0.084
|
|
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
81 |
0.084
|
|
|
|
multicellular organismal reproductive behavior
|
GO:0033057 |
23 |
0.084
|
Worm |
|
|
regulation of embryonic development
|
GO:0045995 |
71 |
0.084
|
|
|
|
paraxial mesoderm morphogenesis
|
GO:0048340 |
10 |
0.084
|
Mouse |
|
|
skeletal muscle cell differentiation
|
GO:0035914 |
66 |
0.084
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.084
|
Mouse |
|
|
lymphocyte anergy
|
GO:0002249 |
4 |
0.084
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
3 |
0.084
|
Mouse |
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
46 |
0.084
|
Human |
|
|
somitogenesis
|
GO:0001756 |
69 |
0.083
|
Mouse |
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.083
|
Mouse |
|
|
brainstem development
|
GO:0003360 |
3 |
0.083
|
Mouse |
|
|
placenta development
|
GO:0001890 |
140 |
0.083
|
|
|
|
heart valve morphogenesis
|
GO:0003179 |
21 |
0.083
|
Mouse |
|
|
regulation of ubiquitin protein transferase activity
|
GO:0051438 |
7 |
0.082
|
Human |
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.082
|
|
|
|
tube closure
|
GO:0060606 |
91 |
0.082
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.082
|
Mouse |
|
|
dendritic cell differentiation
|
GO:0097028 |
26 |
0.082
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
81 |
0.082
|
|
