Mus musculus

33 known processes

Smc3

structural maintenace of chromosomes 3

(Aliases: HCAP,SMC-3,Mmip1,Bamacan,Cspg6,SmcD)

Smc3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of dna endoreduplication GO:0032875 3 0.995
Human
sister chromatid cohesion GO:0007062 12 0.990
Human Yeast Zebrafish
negative regulation of dna dependent dna replication GO:2000104 1 0.983
Human
dna repair GO:0006281 107 0.971
Yeast
meiotic cell cycle process GO:1903046 77 0.929
Yeast
negative regulation of dna replication GO:0008156 4 0.896
Human
chromosome organization involved in meiosis GO:0070192 39 0.865
Yeast
meiotic cell cycle GO:0051321 122 0.864
meiotic nuclear division GO:0007126 115 0.856
synapsis GO:0007129 34 0.851
Yeast
histone methylation GO:0016571 71 0.846
dna metabolic process GO:0006259 303 0.843
Human Yeast
histone modification GO:0016570 159 0.838
protein methylation GO:0006479 81 0.828
chromatin assembly or disassembly GO:0006333 16 0.815
protein alkylation GO:0008213 81 0.812
heterochromatin organization GO:0070828 4 0.803
regulation of chromatin modification GO:1903308 57 0.739
development of primary sexual characteristics GO:0045137 143 0.731
double strand break repair GO:0006302 48 0.729
Yeast
response to ionizing radiation GO:0010212 42 0.717
mitotic sister chromatid cohesion GO:0007064 1 0.713
Yeast Zebrafish
stem cell maintenance GO:0019827 130 0.709
regulation of cell cycle GO:0051726 281 0.677
Human
dna replication GO:0006260 52 0.650
Human
genetic imprinting GO:0071514 27 0.649
spermatogenesis GO:0007283 284 0.649
chromatin modification GO:0016568 187 0.596
gonad development GO:0008406 141 0.585
organelle fission GO:0048285 170 0.575
dna replication independent nucleosome assembly GO:0006336 1 0.572
dna endoreduplication GO:0042023 4 0.566
Human
peptidyl lysine modification GO:0018205 77 0.551
seminiferous tubule development GO:0072520 14 0.530
regulation of dna replication GO:0006275 17 0.522
Human
covalent chromatin modification GO:0016569 163 0.489
dna conformation change GO:0071103 37 0.487
developmental maturation GO:0021700 193 0.481
negative regulation of gene expression epigenetic GO:0045814 15 0.467
methylation GO:0032259 134 0.458
negative regulation of histone methylation GO:0031061 10 0.458
macromolecule methylation GO:0043414 120 0.457
stem cell differentiation GO:0048863 268 0.452
gene silencing GO:0016458 38 0.446
dendrite development GO:0016358 115 0.417
proprioception GO:0019230 4 0.416
mitotic sister chromatid segregation GO:0000070 14 0.406
Yeast Zebrafish
cellular response to dna damage stimulus GO:0006974 207 0.401
Yeast
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.398
ventricular system development GO:0021591 27 0.384
mitotic cell cycle process GO:1903047 159 0.380
Human Yeast Zebrafish
regulation of cellular amino acid metabolic process GO:0006521 5 0.373
regulation of chromatin organization GO:1902275 57 0.366
neuron maturation GO:0042551 29 0.365
mitotic cell cycle GO:0000278 195 0.361
Human Yeast Zebrafish
nuclear division GO:0000280 158 0.358
response to x ray GO:0010165 11 0.340
cellular ketone metabolic process GO:0042180 84 0.337
meiotic chromosome segregation GO:0045132 19 0.335
Yeast
chromatin organization GO:0006325 206 0.316
regulation of cellular amine metabolic process GO:0033238 20 0.294
negative regulation of cell cycle GO:0045786 123 0.287
Human
male sex differentiation GO:0046661 109 0.282
male gamete generation GO:0048232 285 0.278
cellular amine metabolic process GO:0044106 44 0.278
regulation of nuclear cell cycle dna replication GO:0033262 2 0.245
nucleoside monophosphate metabolic process GO:0009123 85 0.243
response to radiation GO:0009314 165 0.226
regulation of chromosome organization GO:0033044 83 0.224
cell cycle checkpoint GO:0000075 47 0.212
chromatin silencing GO:0006342 15 0.209
dna dependent dna replication GO:0006261 24 0.204
Human
genitalia development GO:0048806 37 0.201
positive regulation of chromosome organization GO:2001252 33 0.198
cellular amino acid metabolic process GO:0006520 103 0.196
regulation of histone modification GO:0031056 56 0.194
regulation of protein acetylation GO:1901983 22 0.193
response to light stimulus GO:0009416 135 0.184
meiosis i GO:0007127 60 0.172
Yeast
regulation of transcription by chromatin organization GO:0034401 0 0.170
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.163
protein dna complex subunit organization GO:0071824 28 0.155
positive regulation of cellular amine metabolic process GO:0033240 5 0.147
chromosome segregation GO:0007059 48 0.146
Human Yeast Zebrafish
regulation of mitotic cell cycle GO:0007346 126 0.142
glycerophospholipid metabolic process GO:0006650 71 0.139
spermatid differentiation GO:0048515 115 0.138
cell maturation GO:0048469 127 0.137
regulation of mitotic cell cycle phase transition GO:1901990 73 0.136
regulation of cellular ketone metabolic process GO:0010565 66 0.136
regulation of peptidyl lysine acetylation GO:2000756 22 0.135
negative regulation of cell cycle process GO:0010948 69 0.131
Human
peptidyl amino acid modification GO:0018193 336 0.129
purine nucleoside triphosphate metabolic process GO:0009144 226 0.126
sister chromatid segregation GO:0000819 20 0.124
Yeast Zebrafish
regulation of cell cycle process GO:0010564 160 0.122
Human
negative regulation of chromosome organization GO:2001251 30 0.119
stem cell development GO:0048864 219 0.117
dna packaging GO:0006323 30 0.115
meiotic sister chromatid cohesion GO:0051177 6 0.111
Yeast
response to uv GO:0009411 44 0.110
protein acylation GO:0043543 64 0.106
endocytosis GO:0006897 168 0.102
membrane depolarization GO:0051899 64 0.100
dna recombination GO:0006310 92 0.095
Yeast
regulation of organelle organization GO:0033043 289 0.094
internal peptidyl lysine acetylation GO:0018393 42 0.093
negative regulation of cellular amine metabolic process GO:0033239 1 0.093
mitotic cell cycle checkpoint GO:0007093 31 0.090
mitotic nuclear division GO:0007067 48 0.088
Yeast Zebrafish
dna methylation involved in gamete generation GO:0043046 15 0.087
ribose phosphate metabolic process GO:0019693 291 0.086
regulation of histone acetylation GO:0035065 19 0.085
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.083
signal transduction by p53 class mediator GO:0072331 51 0.081
nucleotide metabolic process GO:0009117 332 0.080
meiotic sister chromatid segregation GO:0045144 6 0.080
Yeast
amine metabolic process GO:0009308 45 0.080
negative regulation of mitotic cell cycle GO:0045930 58 0.077
ribonucleoside triphosphate metabolic process GO:0009199 220 0.077
histone acetylation GO:0016573 41 0.074
purine nucleotide catabolic process GO:0006195 211 0.073
ribonucleoside monophosphate metabolic process GO:0009161 80 0.071
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.068
peptidyl lysine acetylation GO:0018394 45 0.067
replication fork processing GO:0031297 1 0.065
apoptotic signaling pathway GO:0097190 306 0.065
glycosyl compound metabolic process GO:1901657 246 0.063
regulation of histone methylation GO:0031060 30 0.063
neuron projection guidance GO:0097485 141 0.061
nucleobase containing small molecule metabolic process GO:0055086 352 0.060
protein localization to organelle GO:0033365 185 0.058
development of primary male sexual characteristics GO:0046546 88 0.058
male meiosis GO:0007140 37 0.058
ribonucleotide catabolic process GO:0009261 208 0.058
fertilization GO:0009566 127 0.056
adult behavior GO:0030534 135 0.054
cellular biogenic amine metabolic process GO:0006576 28 0.053
neuron apoptotic process GO:0051402 142 0.052
cellular respiration GO:0045333 38 0.050
alcohol metabolic process GO:0006066 116 0.049
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.049
negative regulation of cell cycle phase transition GO:1901988 48 0.049
negative regulation of cellular component organization GO:0051129 194 0.048
axon guidance GO:0007411 141 0.048
intraspecies interaction between organisms GO:0051703 21 0.047
glial cell migration GO:0008347 7 0.046
regulation of chromatin silencing GO:0031935 2 0.046
axonogenesis GO:0007409 274 0.044
positive regulation of cellular component biogenesis GO:0044089 94 0.044
telomere maintenance GO:0000723 19 0.043
ribonucleoside metabolic process GO:0009119 245 0.043
regulation of neuron death GO:1901214 134 0.042
glutamine metabolic process GO:0006541 8 0.042
nuclear dna replication GO:0033260 3 0.042
internal protein amino acid acetylation GO:0006475 42 0.041
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.041
histone lysine methylation GO:0034968 50 0.041
neuromuscular process controlling posture GO:0050884 14 0.041
receptor mediated endocytosis GO:0006898 51 0.041
positive regulation of histone methylation GO:0031062 16 0.041
blastocyst development GO:0001824 80 0.041
visual learning GO:0008542 44 0.040
negative regulation of chromatin modification GO:1903309 19 0.040
mapk cascade GO:0000165 281 0.040
male gonad development GO:0008584 88 0.040
visual behavior GO:0007632 45 0.039
positive regulation of organelle organization GO:0010638 128 0.038
organophosphate catabolic process GO:0046434 232 0.038
regulation of membrane potential GO:0042391 192 0.036
anatomical structure homeostasis GO:0060249 145 0.035
chemotaxis GO:0006935 247 0.034
epithelial cell development GO:0002064 159 0.034
regulation of gene expression by genetic imprinting GO:0006349 15 0.034
nitrogen compound transport GO:0071705 271 0.034
cell type specific apoptotic process GO:0097285 268 0.033
organelle localization GO:0051640 179 0.033
regulation of cell cycle phase transition GO:1901987 77 0.033
response to oxygen levels GO:0070482 62 0.033
positive regulation of chromatin modification GO:1903310 28 0.031
organic hydroxy compound metabolic process GO:1901615 203 0.031
positive regulation of nuclear cell cycle dna replication GO:0010571 1 0.030
organic cyclic compound catabolic process GO:1901361 295 0.030
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.030
purine nucleoside triphosphate catabolic process GO:0009146 203 0.029
positive regulation of cell cycle process GO:0090068 61 0.029
cerebellum development GO:0021549 77 0.029
purine ribonucleotide metabolic process GO:0009150 290 0.029
glutamine family amino acid metabolic process GO:0009064 15 0.028
chromatin remodeling GO:0006338 32 0.028
learning GO:0007612 98 0.027
positive regulation of histone modification GO:0031058 28 0.027
negative regulation of neuron death GO:1901215 98 0.027
dna alkylation GO:0006305 43 0.027
oxidation reduction process GO:0055114 342 0.026
locomotory behavior GO:0007626 195 0.026
cellular response to organonitrogen compound GO:0071417 145 0.026
response to decreased oxygen levels GO:0036293 59 0.026
forebrain development GO:0030900 302 0.025
negative regulation of protein modification process GO:0031400 163 0.025
aromatic compound catabolic process GO:0019439 286 0.025
signal transduction in response to dna damage GO:0042770 21 0.024
social behavior GO:0035176 21 0.023
heterochromatin assembly GO:0031507 2 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.022
double strand break repair via homologous recombination GO:0000724 21 0.022
Yeast
nucleoside triphosphate catabolic process GO:0009143 205 0.022
regulation of respiratory system process GO:0044065 13 0.021
defense response to other organism GO:0098542 197 0.021
nucleoside phosphate catabolic process GO:1901292 222 0.021
purine containing compound metabolic process GO:0072521 311 0.021
response to hypoxia GO:0001666 58 0.021
glycerolipid metabolic process GO:0046486 122 0.021
microtubule based process GO:0007017 236 0.021
Human
intra s dna damage checkpoint GO:0031573 4 0.021
positive regulation of homeostatic process GO:0032846 64 0.020
nucleoside metabolic process GO:0009116 246 0.020
regulation of respiratory gaseous exchange by neurological system process GO:0002087 12 0.019
ribonucleoside monophosphate catabolic process GO:0009158 57 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.019
phospholipid metabolic process GO:0006644 87 0.019
neuron death GO:0070997 154 0.019
positive regulation of synapse assembly GO:0051965 18 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
establishment of organelle localization GO:0051656 122 0.018
heterochromatin organization involved in chromatin silencing GO:0070868 1 0.018
microtubule nucleation GO:0007020 2 0.018
chromatin assembly GO:0031497 13 0.018
carbohydrate derivative catabolic process GO:1901136 231 0.017
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.017
rna processing GO:0006396 105 0.017
regulation of respiratory gaseous exchange GO:0043576 18 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
ribonucleoside catabolic process GO:0042454 206 0.016
cognition GO:0050890 149 0.016
histone h3 k4 methylation GO:0051568 23 0.016
regulation of binding GO:0051098 111 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
cellular lipid metabolic process GO:0044255 323 0.016
adult locomotory behavior GO:0008344 91 0.016
germ cell development GO:0007281 185 0.016
neuromuscular process GO:0050905 99 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 18 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
multicellular organism growth GO:0035264 161 0.015
histone h3 k9 dimethylation GO:0036123 4 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
regulation of intracellular transport GO:0032386 159 0.015
nucleotide catabolic process GO:0009166 217 0.015
lymphocyte differentiation GO:0030098 242 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
regulation of neuron projection development GO:0010975 169 0.014
spermatid development GO:0007286 108 0.014
heterocycle catabolic process GO:0046700 280 0.014
mitotic chromosome condensation GO:0007076 1 0.014
positive regulation of binding GO:0051099 49 0.014
protein modification by small protein removal GO:0070646 21 0.014
negative regulation of synapse assembly GO:0051964 3 0.014
somatic cell dna recombination GO:0016444 51 0.014
respiratory gaseous exchange GO:0007585 43 0.014
ribonucleotide metabolic process GO:0009259 291 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
leukocyte differentiation GO:0002521 342 0.013
regulation of dna dependent dna replication GO:0090329 8 0.013
Human
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
intracellular mrna localization GO:0008298 4 0.013
chromatin mediated maintenance of transcription GO:0048096 2 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
cellular response to inorganic substance GO:0071241 37 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
positive regulation of nervous system development GO:0051962 221 0.012
phosphatidylcholine metabolic process GO:0046470 13 0.012
generation of precursor metabolites and energy GO:0006091 103 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
cellular response to organic cyclic compound GO:0071407 87 0.012
insulin receptor signaling pathway GO:0008286 49 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.012
negative regulation of neuron apoptotic process GO:0043524 92 0.012
atp metabolic process GO:0046034 75 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
catecholamine secretion GO:0050432 15 0.012
nuclear transport GO:0051169 139 0.011
synapse assembly GO:0007416 56 0.011
negative regulation of histone acetylation GO:0035067 7 0.011
nucleosome assembly GO:0006334 7 0.011
long term synaptic potentiation GO:0060291 25 0.011
peptidyl lysine methylation GO:0018022 29 0.011
protein maturation GO:0051604 176 0.011
associative learning GO:0008306 61 0.011
polyol metabolic process GO:0019751 26 0.011
ncrna processing GO:0034470 26 0.011
regionalization GO:0003002 337 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
cardiolipin metabolic process GO:0032048 3 0.011
regulation of protein targeting GO:1903533 61 0.011
organic hydroxy compound transport GO:0015850 93 0.011
protein targeting GO:0006605 143 0.011
response to inorganic substance GO:0010035 96 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
regulation of cellular response to stress GO:0080135 159 0.011
atp catabolic process GO:0006200 55 0.011
rna interference GO:0016246 2 0.011
sensory perception GO:0007600 245 0.011
mitotic recombination GO:0006312 3 0.011
endomembrane system organization GO:0010256 147 0.010
negative regulation of cellular catabolic process GO:0031330 47 0.010
carbohydrate metabolic process GO:0005975 230 0.010
female gamete generation GO:0007292 74 0.010
regulation of lymphocyte activation GO:0051249 240 0.010
adaptive immune response GO:0002250 155 0.010
erk1 and erk2 cascade GO:0070371 77 0.010

Smc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cornelia de lange syndrome DOID:11725 0 0.910
Human
pervasive developmental disorder DOID:0060040 0 0.058
autism spectrum disorder DOID:0060041 0 0.058
disease of mental health DOID:150 0 0.058
developmental disorder of mental health DOID:0060037 0 0.058
central nervous system disease DOID:331 0 0.038
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038
autistic disorder DOID:12849 0 0.036
neurodegenerative disease DOID:1289 0 0.026
physical disorder DOID:0080015 0 0.011