Mus musculus

2 known processes

Smpd2

sphingomyelin phosphodiesterase 2, neutral

(Aliases: AW108287,nSMase,nSMase1)

Smpd2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 323 0.320
monocarboxylic acid metabolic process GO:0032787 191 0.166
regulation of cellular ketone metabolic process GO:0010565 66 0.150
cellular ketone metabolic process GO:0042180 84 0.124
regulation of cellular amino acid metabolic process GO:0006521 5 0.108
oxidation reduction process GO:0055114 342 0.089
cellular amino acid metabolic process GO:0006520 103 0.088
cellular lipid catabolic process GO:0044242 52 0.085
amine metabolic process GO:0009308 45 0.079
cytoplasmic transport GO:0016482 234 0.075
vacuole organization GO:0007033 38 0.068
regulation of cellular amine metabolic process GO:0033238 20 0.064
cation transport GO:0006812 399 0.064
steroid metabolic process GO:0008202 119 0.061
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.055
membrane organization GO:0061024 245 0.052
mapk cascade GO:0000165 281 0.052
glycerolipid metabolic process GO:0046486 122 0.051
cellular response to extracellular stimulus GO:0031668 81 0.050
peptidyl amino acid modification GO:0018193 336 0.050
carboxylic acid catabolic process GO:0046395 51 0.049
negative regulation of cell proliferation GO:0008285 296 0.049
nitrogen compound transport GO:0071705 271 0.048
skin development GO:0043588 220 0.047
response to extracellular stimulus GO:0009991 127 0.047
regulation of vacuole organization GO:0044088 4 0.047
endocytosis GO:0006897 168 0.046
regulation of hormone levels GO:0010817 211 0.046
transmembrane transport GO:0055085 412 0.046
regulation of mapk cascade GO:0043408 248 0.046
maintenance of location GO:0051235 89 0.046
nucleoside phosphate metabolic process GO:0006753 338 0.044
nucleotide metabolic process GO:0009117 332 0.043
organic acid catabolic process GO:0016054 51 0.041
cytokine production GO:0001816 319 0.041
cellular response to starvation GO:0009267 57 0.041
regulation of organelle organization GO:0033043 289 0.041
purine nucleotide metabolic process GO:0006163 302 0.041
regulation of cellular catabolic process GO:0031329 242 0.039
lipid localization GO:0010876 126 0.038
lipid biosynthetic process GO:0008610 179 0.038
small molecule catabolic process GO:0044282 71 0.038
monocarboxylic acid catabolic process GO:0072329 27 0.037
cellular amine metabolic process GO:0044106 44 0.036
protein targeting GO:0006605 143 0.036
response to nutrient levels GO:0031667 109 0.036
nucleobase containing small molecule metabolic process GO:0055086 352 0.035
response to light stimulus GO:0009416 135 0.035
regulation of cholesterol metabolic process GO:0090181 14 0.035
organic hydroxy compound metabolic process GO:1901615 203 0.034
peptide hormone secretion GO:0030072 109 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
protein maturation GO:0051604 176 0.032
macroautophagy GO:0016236 21 0.032
response to starvation GO:0042594 65 0.032
regulation of cytokine production GO:0001817 266 0.032
organonitrogen compound catabolic process GO:1901565 264 0.032
ribonucleotide metabolic process GO:0009259 291 0.032
skeletal system development GO:0001501 356 0.031
purine containing compound metabolic process GO:0072521 311 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.030
fatty acid oxidation GO:0019395 28 0.030
positive regulation of protein modification process GO:0031401 299 0.029
transmission of nerve impulse GO:0019226 76 0.029
ubiquitin dependent protein catabolic process GO:0006511 129 0.028
protein localization to peroxisome GO:0072662 4 0.028
protein localization to organelle GO:0033365 185 0.027
negative regulation of protein metabolic process GO:0051248 282 0.027
regulation of membrane potential GO:0042391 192 0.027
nucleoside metabolic process GO:0009116 246 0.026
regulation of cellular component biogenesis GO:0044087 181 0.026
organonitrogen compound biosynthetic process GO:1901566 192 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.026
cellular component assembly involved in morphogenesis GO:0010927 139 0.026
organophosphate biosynthetic process GO:0090407 122 0.025
protein processing GO:0016485 163 0.025
cellular response to nutrient levels GO:0031669 64 0.025
multicellular organism growth GO:0035264 161 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
lateral inhibition GO:0046331 1 0.025
covalent chromatin modification GO:0016569 163 0.025
histone modification GO:0016570 159 0.024
glycosyl compound metabolic process GO:1901657 246 0.024
germ cell development GO:0007281 185 0.024
intracellular protein transport GO:0006886 204 0.024
negative regulation of nervous system development GO:0051961 156 0.024
aromatic compound catabolic process GO:0019439 286 0.024
lipid modification GO:0030258 65 0.024
muscle cell differentiation GO:0042692 261 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
fatty acid metabolic process GO:0006631 121 0.024
regulation of t cell proliferation GO:0042129 92 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
protein import GO:0017038 101 0.024
regulation of cell activation GO:0050865 289 0.023
negative regulation of phosphorylation GO:0042326 166 0.023
regulation of neuron differentiation GO:0045664 281 0.023
myeloid leukocyte differentiation GO:0002573 119 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
hematopoietic progenitor cell differentiation GO:0002244 143 0.023
regulation of secretion GO:0051046 274 0.023
nucleoside triphosphate metabolic process GO:0009141 230 0.023
regulation of lipid metabolic process GO:0019216 118 0.023
response to growth factor GO:0070848 198 0.023
nucleotide catabolic process GO:0009166 217 0.023
cofactor metabolic process GO:0051186 80 0.022
microtubule based process GO:0007017 236 0.022
t cell activation GO:0042110 289 0.022
regulation of cellular response to stress GO:0080135 159 0.022
negative regulation of phosphate metabolic process GO:0045936 184 0.022
blood vessel morphogenesis GO:0048514 285 0.022
response to radiation GO:0009314 165 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
rhythmic process GO:0048511 174 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
neutral lipid metabolic process GO:0006638 57 0.021
metal ion homeostasis GO:0055065 189 0.021
locomotory behavior GO:0007626 195 0.021
cellular response to external stimulus GO:0071496 88 0.021
epidermis development GO:0008544 187 0.021
smoothened signaling pathway GO:0007224 105 0.021
chromatin modification GO:0016568 187 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.020
organelle assembly GO:0070925 177 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.020
regulation of transferase activity GO:0051338 263 0.020
sulfur compound metabolic process GO:0006790 100 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
positive regulation of programmed cell death GO:0043068 218 0.020
negative regulation of cytokine production GO:0001818 84 0.020
protein catabolic process GO:0030163 221 0.020
negative regulation of cell development GO:0010721 169 0.020
lipid catabolic process GO:0016042 69 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
cell adhesion GO:0007155 329 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
regulation of cell motility GO:2000145 236 0.020
modification dependent protein catabolic process GO:0019941 133 0.019
regulation of secretion by cell GO:1903530 249 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
negative regulation of synapse assembly GO:0051964 3 0.019
peroxisomal transport GO:0043574 4 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
nuclear transport GO:0051169 139 0.019
proteasomal protein catabolic process GO:0010498 98 0.019
central nervous system neuron differentiation GO:0021953 162 0.019
chemotaxis GO:0006935 247 0.019
purine containing compound catabolic process GO:0072523 213 0.019
regulation of vesicle mediated transport GO:0060627 139 0.019
protein import into peroxisome matrix GO:0016558 3 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
neuronal action potential GO:0019228 54 0.018
response to organonitrogen compound GO:0010243 246 0.018
regulation of binding GO:0051098 111 0.018
cytokine biosynthetic process GO:0042089 68 0.018
leukocyte differentiation GO:0002521 342 0.018
endomembrane system organization GO:0010256 147 0.018
cation transmembrane transport GO:0098655 266 0.018
innate immune response GO:0045087 157 0.018
peptide secretion GO:0002790 114 0.018
regulation of protein serine threonine kinase activity GO:0071900 157 0.018
striated muscle tissue development GO:0014706 293 0.018
inorganic cation transmembrane transport GO:0098662 207 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.017
organic acid biosynthetic process GO:0016053 86 0.017
sensory perception GO:0007600 245 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
forebrain development GO:0030900 302 0.017
small molecule biosynthetic process GO:0044283 132 0.017
heterocycle catabolic process GO:0046700 280 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
urogenital system development GO:0001655 261 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
ameboidal type cell migration GO:0001667 128 0.017
ribonucleotide catabolic process GO:0009261 208 0.017
regulation of lymphocyte proliferation GO:0050670 117 0.017
alpha amino acid metabolic process GO:1901605 59 0.017
regulation of kinase activity GO:0043549 249 0.017
embryonic organ morphogenesis GO:0048562 276 0.016
nucleoside catabolic process GO:0009164 206 0.016
negative regulation of cellular amine metabolic process GO:0033239 1 0.016
protein ubiquitination GO:0016567 171 0.016
methylation GO:0032259 134 0.016
response to drug GO:0042493 75 0.016
response to organic cyclic compound GO:0014070 198 0.016
inorganic ion transmembrane transport GO:0098660 234 0.016
ossification GO:0001503 216 0.016
stem cell development GO:0048864 219 0.016
spermatogenesis GO:0007283 284 0.016
positive regulation of cell activation GO:0050867 158 0.016
positive regulation of kinase activity GO:0033674 155 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
positive regulation of cell development GO:0010720 237 0.016
telencephalon development GO:0021537 186 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
very long chain fatty acid catabolic process GO:0042760 2 0.016
regulation of hydrolase activity GO:0051336 246 0.016
regulation of t cell activation GO:0050863 170 0.016
regulation of endocytosis GO:0030100 69 0.016
regulation of protein kinase activity GO:0045859 232 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
carbohydrate homeostasis GO:0033500 128 0.016
cardiac chamber morphogenesis GO:0003206 93 0.016
regulation of hormone secretion GO:0046883 88 0.015
multicellular organismal signaling GO:0035637 91 0.015
fatty acid beta oxidation GO:0006635 16 0.015
negative regulation of neuron projection development GO:0010977 50 0.015
very long chain fatty acid metabolic process GO:0000038 8 0.015
kidney development GO:0001822 213 0.015
regulation of map kinase activity GO:0043405 120 0.015
regulation of protein maturation GO:1903317 96 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
regulation of cell cycle GO:0051726 281 0.015
amide transport GO:0042886 138 0.015
anion transport GO:0006820 177 0.015
organophosphate catabolic process GO:0046434 232 0.015
cognition GO:0050890 149 0.015
inflammatory response GO:0006954 244 0.015
cation homeostasis GO:0055080 212 0.015
neuron migration GO:0001764 122 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.015
muscle tissue development GO:0060537 308 0.015
cellular response to lipid GO:0071396 145 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
positive regulation of lymphocyte activation GO:0051251 140 0.015
cellular homeostasis GO:0019725 240 0.015
regulation of intracellular transport GO:0032386 159 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
macromolecule catabolic process GO:0009057 281 0.015
regulation of osteoblast differentiation GO:0045667 67 0.015
gland development GO:0048732 330 0.014
compound eye development GO:0048749 1 0.014
protein localization to nucleus GO:0034504 121 0.014
regulation of cellular component size GO:0032535 121 0.014
camera type eye development GO:0043010 266 0.014
protein targeting to peroxisome GO:0006625 4 0.014
positive regulation of t cell activation GO:0050870 101 0.014
cellular ion homeostasis GO:0006873 165 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
cellular chemical homeostasis GO:0055082 215 0.014
neural tube development GO:0021915 160 0.014
circulatory system process GO:0003013 197 0.014
epithelial cell proliferation GO:0050673 174 0.014
polysaccharide metabolic process GO:0005976 39 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
synapse organization GO:0050808 125 0.014
tube formation GO:0035148 140 0.014
embryonic epithelial tube formation GO:0001838 130 0.014
cytokine metabolic process GO:0042107 71 0.014
sphingosine 1 phosphate signaling pathway GO:0003376 3 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.013
regulation of leukocyte proliferation GO:0070663 121 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
ribose phosphate metabolic process GO:0019693 291 0.013
immune effector process GO:0002252 321 0.013
sterol metabolic process GO:0016125 58 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
action potential GO:0001508 78 0.013
myeloid cell differentiation GO:0030099 233 0.013
negative regulation of cellular catabolic process GO:0031330 47 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
regulation of cell projection organization GO:0031344 206 0.013
organelle fission GO:0048285 170 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.013
lymphocyte proliferation GO:0046651 164 0.013
peptidyl lysine modification GO:0018205 77 0.013
plasma membrane organization GO:0007009 90 0.013
autophagic vacuole assembly GO:0000045 13 0.013
regulation of ion transport GO:0043269 215 0.013
chromatin organization GO:0006325 206 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
t cell proliferation GO:0042098 120 0.013
regulation of response to biotic stimulus GO:0002831 38 0.013
alcohol metabolic process GO:0006066 116 0.013
connective tissue development GO:0061448 179 0.013
angiogenesis GO:0001525 201 0.013
ras protein signal transduction GO:0007265 77 0.013
bone development GO:0060348 120 0.013
regulation of cytokine biosynthetic process GO:0042035 59 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
nuclear division GO:0000280 158 0.013
regulation of autophagic vacuole assembly GO:2000785 4 0.013
single organism cell adhesion GO:0098602 156 0.013
ion transmembrane transport GO:0034220 361 0.013
glial cell differentiation GO:0010001 131 0.013
regulation of protein localization GO:0032880 231 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
apoptotic signaling pathway GO:0097190 306 0.012
positive regulation of organelle organization GO:0010638 128 0.012
ear development GO:0043583 200 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
defense response to other organism GO:0098542 197 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.012
gtp metabolic process GO:0046039 144 0.012
membrane fusion GO:0061025 38 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
regulation of defense response GO:0031347 233 0.012
dna metabolic process GO:0006259 303 0.012
organelle localization GO:0051640 179 0.012
heart morphogenesis GO:0003007 178 0.012
myelination GO:0042552 74 0.012
renal system development GO:0072001 225 0.012
lymphocyte differentiation GO:0030098 242 0.012
peptide transport GO:0015833 133 0.012
macromolecule methylation GO:0043414 120 0.012
actin filament organization GO:0007015 113 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
cellular protein catabolic process GO:0044257 155 0.012
learning or memory GO:0007611 148 0.012
hormone secretion GO:0046879 128 0.012
synaptic transmission GO:0007268 329 0.012
skeletal muscle organ development GO:0060538 163 0.012
negative regulation of neuron differentiation GO:0045665 101 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
negative regulation of organelle organization GO:0010639 90 0.011
negative regulation of secretion GO:0051048 61 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
lipid homeostasis GO:0055088 63 0.011
neuromuscular process GO:0050905 99 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
negative regulation of molecular function GO:0044092 258 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
positive regulation of cytokine production GO:0001819 174 0.011
glycerophospholipid metabolic process GO:0006650 71 0.011
leukocyte migration GO:0050900 124 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
actin cytoskeleton organization GO:0030036 220 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
mitochondrion organization GO:0007005 134 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
calcium ion homeostasis GO:0055074 127 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
negative regulation of growth GO:0045926 99 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
protein localization to membrane GO:0072657 108 0.011
cellular response to acid chemical GO:0071229 68 0.011
hormone metabolic process GO:0042445 86 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
gastrulation GO:0007369 116 0.011
epithelial tube formation GO:0072175 130 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.011
establishment of protein localization to peroxisome GO:0072663 4 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.011
divalent inorganic cation transport GO:0072511 178 0.011
response to acid chemical GO:0001101 111 0.011
nuclear import GO:0051170 95 0.011
regulation of multi organism process GO:0043900 111 0.011
leukocyte proliferation GO:0070661 172 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
lipid oxidation GO:0034440 29 0.011
positive regulation of transferase activity GO:0051347 167 0.010
regulation of cell adhesion GO:0030155 154 0.010
organic hydroxy compound biosynthetic process GO:1901617 77 0.010
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.010
male gamete generation GO:0048232 285 0.010
development of primary sexual characteristics GO:0045137 143 0.010
nucleotide biosynthetic process GO:0009165 78 0.010
negative regulation of chemokine production GO:0032682 4 0.010
positive regulation of cell death GO:0010942 224 0.010
homeostasis of number of cells GO:0048872 210 0.010
negative regulation of apoptotic signaling pathway GO:2001234 104 0.010
tissue homeostasis GO:0001894 115 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
cardiac chamber development GO:0003205 108 0.010
spermatid development GO:0007286 108 0.010
regulation of reproductive process GO:2000241 66 0.010

Smpd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.033
inherited metabolic disorder DOID:655 0 0.033
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
central nervous system disease DOID:331 0 0.012
immune system disease DOID:2914 0 0.010