Mus musculus

26 known processes

Sparc

secreted acidic cysteine rich glycoprotein

(Aliases: BM-40,AA517111)

Sparc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular matrix organization GO:0030198 147 0.896
Fly
extracellular structure organization GO:0043062 148 0.784
Fly
regulation of proteolysis GO:0030162 164 0.496
wound healing GO:0042060 157 0.475
Rat
regulation of cell motility GO:2000145 236 0.356
Human
muscle tissue development GO:0060537 308 0.310
response to acid chemical GO:0001101 111 0.249
Rat
protein hydroxylation GO:0018126 4 0.235
response to organic cyclic compound GO:0014070 198 0.235
Rat
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.226
cell adhesion GO:0007155 329 0.208
cerebral cortex development GO:0021987 86 0.199
cell matrix adhesion GO:0007160 68 0.196
negative regulation of toll signaling pathway GO:0045751 1 0.183
chondrocyte development GO:0002063 24 0.182
cell substrate adhesion GO:0031589 130 0.166
skeletal system development GO:0001501 356 0.160
regulation of cell substrate adhesion GO:0010810 73 0.160
response to amino acid GO:0043200 37 0.152
negative regulation of cell migration GO:0030336 59 0.150
inner ear morphogenesis GO:0042472 101 0.149
Zebrafish
cardiac muscle tissue morphogenesis GO:0055008 44 0.144
retinal blood vessel morphogenesis GO:0061304 3 0.139
embryonic organ morphogenesis GO:0048562 276 0.133
Zebrafish
sensory organ morphogenesis GO:0090596 242 0.127
Zebrafish
transmission of nerve impulse GO:0019226 76 0.122
forebrain development GO:0030900 302 0.121
response to organonitrogen compound GO:0010243 246 0.121
Rat
proteoglycan metabolic process GO:0006029 38 0.121
multicellular organismal signaling GO:0035637 91 0.118
regulation of toll signaling pathway GO:0008592 1 0.108
long chain fatty acid import GO:0044539 2 0.106
apoptotic signaling pathway GO:0097190 306 0.102
regulation of phospholipid biosynthetic process GO:0071071 3 0.099
blood vessel morphogenesis GO:0048514 285 0.098
Human
connective tissue development GO:0061448 179 0.093
Zebrafish
extracellular fibril organization GO:0043206 2 0.090
response to growth factor GO:0070848 198 0.085
rho protein signal transduction GO:0007266 32 0.082
protein trimerization GO:0070206 13 0.082
collagen fibril organization GO:0030199 32 0.081
regulation of apoptotic signaling pathway GO:2001233 197 0.080
small gtpase mediated signal transduction GO:0007264 97 0.076
cellular response to abiotic stimulus GO:0071214 56 0.074
insulin processing GO:0030070 2 0.073
neutrophil apoptotic process GO:0001781 3 0.073
negative regulation of apoptotic signaling pathway GO:2001234 104 0.072
protein maturation GO:0051604 176 0.067
regulation of peptidase activity GO:0052547 96 0.065
chondrocyte differentiation GO:0002062 72 0.065
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.062
extrinsic apoptotic signaling pathway GO:0097191 126 0.062
regulation of neutrophil apoptotic process GO:0033029 1 0.061
glycoprotein metabolic process GO:0009100 116 0.058
notochord development GO:0030903 20 0.056
protein heterooligomerization GO:0051291 14 0.055
regulation of cell adhesion GO:0030155 154 0.054
oviduct development GO:0060066 3 0.053
regulation of system process GO:0044057 200 0.051
limb morphogenesis GO:0035108 149 0.051
positive regulation of cell death GO:0010942 224 0.051
cellular modified amino acid metabolic process GO:0006575 63 0.049
skeletal muscle organ development GO:0060538 163 0.048
sensory perception GO:0007600 245 0.048
regulation of cell migration GO:0030334 219 0.047
Human
cellular response to amino acid stimulus GO:0071230 29 0.047
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.047
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
peptidyl proline hydroxylation GO:0019511 3 0.045
neuron migration GO:0001764 122 0.045
engulfment of apoptotic cell GO:0043652 3 0.044
positive regulation of apoptotic process GO:0043065 217 0.042
cardiac chamber development GO:0003205 108 0.041
regulation of ras protein signal transduction GO:0046578 114 0.041
membrane raft assembly GO:0001765 3 0.040
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.039
cellular response to growth factor stimulus GO:0071363 197 0.039
heart morphogenesis GO:0003007 178 0.039
tissue homeostasis GO:0001894 115 0.039
cellular response to organonitrogen compound GO:0071417 145 0.038
skeletal system morphogenesis GO:0048705 203 0.038
camera type eye development GO:0043010 266 0.038
fibril organization GO:0097435 2 0.037
cellular divalent inorganic cation homeostasis GO:0072503 127 0.036
cellular calcium ion homeostasis GO:0006874 119 0.036
divalent inorganic cation homeostasis GO:0072507 138 0.036
response to extracellular stimulus GO:0009991 127 0.036
Rat
cellular response to acid chemical GO:0071229 68 0.036
muscle cell differentiation GO:0042692 261 0.035
cellular amino acid metabolic process GO:0006520 103 0.035
action potential GO:0001508 78 0.034
protein oligomerization GO:0051259 67 0.034
appendage development GO:0048736 166 0.034
positive regulation of ras protein signal transduction GO:0046579 13 0.033
regulation of hydrolase activity GO:0051336 246 0.033
fibrinolysis GO:0042730 3 0.033
cardiac muscle tissue development GO:0048738 130 0.033
transcription initiation from rna polymerase i promoter GO:0006361 4 0.032
cellular component assembly involved in morphogenesis GO:0010927 139 0.032
actin cytoskeleton organization GO:0030036 220 0.032
cation homeostasis GO:0055080 212 0.032
endothelial cell migration GO:0043542 44 0.031
Human
basement membrane organization GO:0071711 8 0.031
circulatory system process GO:0003013 197 0.031
limb development GO:0060173 166 0.031
cardiac ventricle morphogenesis GO:0003208 50 0.031
ras protein signal transduction GO:0007265 77 0.030
defense response to other organism GO:0098542 197 0.030
limb bud formation GO:0060174 10 0.029
cardiac chamber morphogenesis GO:0003206 93 0.029
positive regulation of cell projection organization GO:0031346 95 0.029
cellular amine metabolic process GO:0044106 44 0.028
pallium development GO:0021543 120 0.028
transmembrane transport GO:0055085 412 0.028
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.028
regulation of endopeptidase activity GO:0052548 89 0.028
termination of rna polymerase i transcription GO:0006363 2 0.027
response to inorganic substance GO:0010035 96 0.027
Rat
cardiac muscle cell differentiation GO:0055007 69 0.027
response to bmp GO:0071772 14 0.027
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.026
establishment of glial blood brain barrier GO:0060857 2 0.026
angiogenesis GO:0001525 201 0.026
Human
retina development in camera type eye GO:0060041 119 0.026
regulation of vesicle mediated transport GO:0060627 139 0.026
negative regulation of molecular function GO:0044092 258 0.025
negative regulation of cell motility GO:2000146 61 0.025
axon ensheathment GO:0008366 76 0.025
protein processing GO:0016485 163 0.025
telencephalon development GO:0021537 186 0.025
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.025
regulation of multi organism process GO:0043900 111 0.025
digestive tract development GO:0048565 190 0.025
Fly
notochord cell differentiation GO:0060034 1 0.024
cellular ketone metabolic process GO:0042180 84 0.024
metal ion homeostasis GO:0055065 189 0.024
plasma membrane organization GO:0007009 90 0.024
signal transduction in absence of ligand GO:0038034 55 0.023
response to peptide hormone GO:0043434 127 0.023
Rat
negative regulation of cell development GO:0010721 169 0.023
response to monoamine GO:0071867 4 0.022
endochondral bone morphogenesis GO:0060350 50 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.022
cellular lipid metabolic process GO:0044255 323 0.022
multicellular organismal aging GO:0010259 24 0.022
g1 s transition of mitotic cell cycle GO:0000082 57 0.022
metanephric glomerular basement membrane development GO:0072274 1 0.021
cellular response to external stimulus GO:0071496 88 0.021
cell junction assembly GO:0034329 52 0.021
response to oxidative stress GO:0006979 123 0.021
protein localization to plasma membrane GO:0072659 57 0.021
bmp signaling pathway GO:0030509 93 0.021
cellular response to bmp stimulus GO:0071773 14 0.021
regulation of cell cycle GO:0051726 281 0.021
striated muscle tissue development GO:0014706 293 0.020
regulation of tooth mineralization GO:0070170 2 0.020
regulation of neuron projection development GO:0010975 169 0.020
peptidyl amino acid modification GO:0018193 336 0.020
defense response to fungus GO:0050832 12 0.020
cardiac cell development GO:0055006 41 0.020
membrane organization GO:0061024 245 0.019
response to insulin GO:0032868 100 0.019
regulation of rho protein signal transduction GO:0035023 71 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
glomerular basement membrane development GO:0032836 8 0.019
positive regulation of cell migration GO:0030335 109 0.018
Human
monocarboxylic acid metabolic process GO:0032787 191 0.018
oxidation reduction process GO:0055114 342 0.018
bone development GO:0060348 120 0.018
collagen metabolic process GO:0032963 17 0.018
modulation by virus of host process GO:0019054 2 0.018
regulation of phosphatidylcholine biosynthetic process GO:2001245 2 0.018
response to transforming growth factor beta GO:0071559 88 0.018
negative regulation of protein metabolic process GO:0051248 282 0.017
muscle tissue morphogenesis GO:0060415 53 0.017
cation transport GO:0006812 399 0.017
integrin biosynthetic process GO:0045112 1 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
calcium ion homeostasis GO:0055074 127 0.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.016
positive regulation of peptide secretion GO:0002793 33 0.016
regulation of angiogenesis GO:0045765 81 0.016
Human
negative regulation of nervous system development GO:0051961 156 0.016
defense response to bacterium GO:0042742 119 0.016
blood circulation GO:0008015 195 0.016
negative regulation of phagocytosis GO:0050765 4 0.016
palate development GO:0060021 76 0.016
regulation of blood circulation GO:1903522 93 0.016
regeneration GO:0031099 38 0.016
digestive tract morphogenesis GO:0048546 147 0.016
Fly
actin polymerization or depolymerization GO:0008154 54 0.016
lamellipodium organization GO:0097581 29 0.016
cardiac ventricle development GO:0003231 83 0.016
cardiac muscle cell development GO:0055013 39 0.016
glycerophospholipid biosynthetic process GO:0046474 32 0.016
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity GO:0031585 2 0.016
head morphogenesis GO:0060323 34 0.015
protein localization to membrane GO:0072657 108 0.015
bone morphogenesis GO:0060349 78 0.015
integrin mediated signaling pathway GO:0007229 27 0.015
negative regulation of protein processing GO:0010955 79 0.015
ossification GO:0001503 216 0.015
Rat
lipid localization GO:0010876 126 0.015
negative regulation of hydrolase activity GO:0051346 71 0.015
cell type specific apoptotic process GO:0097285 268 0.015
digestive system development GO:0055123 200 0.015
Fly
reactive nitrogen species metabolic process GO:2001057 0 0.015
acylglycerol metabolic process GO:0006639 55 0.014
positive regulation of growth GO:0045927 104 0.014
Worm
skin development GO:0043588 220 0.014
cellular response to mechanical stimulus GO:0071260 7 0.014
multicellular organism growth GO:0035264 161 0.014
Worm
gastrulation GO:0007369 116 0.014
response to nutrient levels GO:0031667 109 0.014
Rat
cellular response to thyroid hormone stimulus GO:0097067 1 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
amine metabolic process GO:0009308 45 0.014
negative regulation of protein activation cascade GO:2000258 3 0.014
divalent metal ion transport GO:0070838 172 0.014
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.014
cellular chemical homeostasis GO:0055082 215 0.014
cellular ion homeostasis GO:0006873 165 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
interspecies interaction between organisms GO:0044419 83 0.014
actin filament polymerization GO:0030041 44 0.014
cytoplasmic transport GO:0016482 234 0.014
reactive oxygen species metabolic process GO:0072593 84 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
protein folding GO:0006457 28 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
regulation of cell cycle process GO:0010564 160 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
positive regulation of myeloid cell apoptotic process GO:0033034 4 0.013
regulation of organelle organization GO:0033043 289 0.013
regulation of map kinase activity GO:0043405 120 0.013
cell cell junction organization GO:0045216 72 0.013
carboxylic acid transport GO:0046942 100 0.013
divalent inorganic cation transport GO:0072511 178 0.013
negative regulation of cell adhesion GO:0007162 45 0.013
negative regulation of bmp signaling pathway GO:0030514 35 0.013
negative regulation of blood vessel morphogenesis GO:2000181 25 0.012
Human
protein catabolic process GO:0030163 221 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
substrate adhesion dependent cell spreading GO:0034446 30 0.012
collagen biosynthetic process GO:0032964 7 0.012
regulation of cell projection organization GO:0031344 206 0.012
response to reactive oxygen species GO:0000302 56 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
muscle cell development GO:0055001 133 0.012
response to thyroid hormone GO:0097066 2 0.012
negative regulation of proteolysis GO:0045861 74 0.012
regulation of body fluid levels GO:0050878 162 0.012
regulation of secretion GO:0051046 274 0.012
organelle fission GO:0048285 170 0.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.012
chondroitin sulfate metabolic process GO:0030204 17 0.012
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.012
myosin filament assembly GO:0031034 2 0.012
response to radiation GO:0009314 165 0.012
regulation of transferase activity GO:0051338 263 0.012
negative regulation of tooth mineralization GO:0070171 1 0.011
cell chemotaxis GO:0060326 81 0.011
hair follicle morphogenesis GO:0031069 29 0.011
cartilage development GO:0051216 140 0.011
Zebrafish
regulation of binding GO:0051098 111 0.011
nephron development GO:0072006 109 0.011
single organism cell adhesion GO:0098602 156 0.011
positive regulation of camp metabolic process GO:0030816 19 0.011
negative regulation of peptidase activity GO:0010466 46 0.011
spermatogenesis GO:0007283 284 0.011
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
regulation of endothelial cell apoptotic process GO:2000351 9 0.011
vegf activated neuropilin signaling pathway involved in axon guidance GO:1902378 1 0.011
endoderm formation GO:0001706 20 0.011
negative regulation of neuron migration GO:2001223 6 0.011
mapk cascade GO:0000165 281 0.011
apical constriction GO:0003383 4 0.011
tissue migration GO:0090130 68 0.011
Human
regulation of protein kinase activity GO:0045859 232 0.011
macromolecule catabolic process GO:0009057 281 0.011
striated muscle contraction GO:0006941 45 0.011
nucleotide metabolic process GO:0009117 332 0.011
cellular water homeostasis GO:0009992 2 0.011
cell growth GO:0016049 130 0.011
t cell activation GO:0042110 289 0.010
positive regulation of ion transport GO:0043270 65 0.010
negative regulation of cellular component organization GO:0051129 194 0.010
synaptic transmission GO:0007268 329 0.010
organophosphate biosynthetic process GO:0090407 122 0.010
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 1 0.010
organic acid transport GO:0015849 101 0.010
cellular protein complex assembly GO:0043623 116 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
regulation of neuron migration GO:2001222 22 0.010
regulation of membrane potential GO:0042391 192 0.010
i kappab kinase nf kappab signaling GO:0007249 85 0.010
glucose homeostasis GO:0042593 128 0.010
visual learning GO:0008542 44 0.010
mitochondrion organization GO:0007005 134 0.010
sphingolipid metabolic process GO:0006665 45 0.010
positive regulation of endopeptidase activity GO:0010950 43 0.010

Sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.875
musculoskeletal system disease DOID:17 0 0.875
connective tissue disease DOID:65 0 0.809
bone development disease DOID:0080006 0 0.739
bone disease DOID:0080001 0 0.739
osteochondrodysplasia DOID:2256 0 0.521
osteogenesis imperfecta DOID:12347 0 0.521
nervous system disease DOID:863 0 0.144
neuromuscular disease DOID:440 0 0.130
charcot marie tooth disease DOID:10595 0 0.130
neuropathy DOID:870 0 0.130
myopathy DOID:423 0 0.111
muscular disease DOID:0080000 0 0.111
muscle tissue disease DOID:66 0 0.111
immune system disease DOID:2914 0 0.071
collagen disease DOID:854 0 0.071
osteoporosis DOID:11476 0 0.057
bone remodeling disease DOID:0080005 0 0.057
bone resorption disease DOID:0080011 0 0.057
sensory system disease DOID:0050155 0 0.056
eye and adnexa disease DOID:1492 0 0.056
eye disease DOID:5614 0 0.056
congenital muscular dystrophy DOID:0050557 0 0.050
muscular dystrophy DOID:9884 0 0.050
ehlers danlos syndrome DOID:13359 0 0.032
retinal disease DOID:5679 0 0.022
retinal degeneration DOID:8466 0 0.022
disease of metabolism DOID:0014667 0 0.014
acquired metabolic disease DOID:0060158 0 0.014
hypersensitivity reaction disease DOID:0060056 0 0.011