Mus musculus

6 known processes

Spast

spastin

(Aliases: mKIAA1083,Spg4)

Spast biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 187 0.199
cellular macromolecule catabolic process GO:0044265 206 0.153
macromolecule catabolic process GO:0009057 281 0.124
modification dependent protein catabolic process GO:0019941 133 0.117
protein modification by small protein conjugation or removal GO:0070647 207 0.106
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.095
organic cyclic compound catabolic process GO:1901361 295 0.087
Human Fly
covalent chromatin modification GO:0016569 163 0.079
small gtpase mediated signal transduction GO:0007264 97 0.079
cellular protein catabolic process GO:0044257 155 0.075
gene silencing GO:0016458 38 0.073
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.073
protein ubiquitination GO:0016567 171 0.072
protein localization to organelle GO:0033365 185 0.071
regulation of protein transport GO:0051223 163 0.066
proteasomal protein catabolic process GO:0010498 98 0.065
male gamete generation GO:0048232 285 0.061
ras protein signal transduction GO:0007265 77 0.061
protein catabolic process GO:0030163 221 0.061
organelle assembly GO:0070925 177 0.059
establishment of protein localization to organelle GO:0072594 118 0.058
ubiquitin dependent protein catabolic process GO:0006511 129 0.058
positive regulation of nfat protein import into nucleus GO:0051533 1 0.057
regulation of cellular catabolic process GO:0031329 242 0.056
regulation of protein localization GO:0032880 231 0.056
nuclear transport GO:0051169 139 0.056
regulation of cellular component biogenesis GO:0044087 181 0.054
Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.053
Fly
chromatin modification GO:0016568 187 0.053
membrane organization GO:0061024 245 0.052
forebrain development GO:0030900 302 0.051
regulation of organelle organization GO:0033043 289 0.049
Zebrafish Fly
mapk cascade GO:0000165 281 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
response to growth factor GO:0070848 198 0.048
cellular response to growth factor stimulus GO:0071363 197 0.048
nucleoside phosphate catabolic process GO:1901292 222 0.047
Human Fly
posttranscriptional regulation of gene expression GO:0010608 155 0.047
purine nucleoside catabolic process GO:0006152 205 0.046
Human Fly
axonogenesis GO:0007409 274 0.045
Zebrafish
regulation of cellular amine metabolic process GO:0033238 20 0.045
chromatin organization GO:0006325 206 0.044
nucleocytoplasmic transport GO:0006913 139 0.044
chemotaxis GO:0006935 247 0.044
regulation of establishment of protein localization GO:0070201 181 0.044
purine nucleoside triphosphate catabolic process GO:0009146 203 0.044
Human Fly
regulation of cell motility GO:2000145 236 0.043
negative regulation of cellular protein metabolic process GO:0032269 247 0.042
dna metabolic process GO:0006259 303 0.041
protein targeting GO:0006605 143 0.041
striated muscle tissue development GO:0014706 293 0.041
cellular response to dna damage stimulus GO:0006974 207 0.041
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.040
compound eye development GO:0048749 1 0.040
ribonucleotide metabolic process GO:0009259 291 0.039
Human Fly
carbohydrate derivative catabolic process GO:1901136 231 0.039
Human Fly
histone modification GO:0016570 159 0.039
nuclear import GO:0051170 95 0.038
negative regulation of mitotic cell cycle GO:0045930 58 0.037
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.037
protein import GO:0017038 101 0.037
intracellular protein transport GO:0006886 204 0.037
cellular amine metabolic process GO:0044106 44 0.037
multicellular organism growth GO:0035264 161 0.035
negative regulation of synapse assembly GO:0051964 3 0.035
Fly
negative regulation of cell cycle GO:0045786 123 0.035
nucleotide metabolic process GO:0009117 332 0.034
Human Fly
single organism nuclear import GO:1902593 95 0.033
negative regulation of protein modification process GO:0031400 163 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.033
homeostasis of number of cells GO:0048872 210 0.032
peptidyl amino acid modification GO:0018193 336 0.032
immune effector process GO:0002252 321 0.032
g1 s transition of mitotic cell cycle GO:0000082 57 0.032
ribonucleoside triphosphate metabolic process GO:0009199 220 0.032
Human Fly
response to transforming growth factor beta GO:0071559 88 0.032
amine metabolic process GO:0009308 45 0.031
negative regulation of protein metabolic process GO:0051248 282 0.031
regulation of intracellular transport GO:0032386 159 0.030
purine containing compound metabolic process GO:0072521 311 0.030
Human Fly
cellular amino acid metabolic process GO:0006520 103 0.030
microtubule severing GO:0051013 5 0.030
organophosphate catabolic process GO:0046434 232 0.030
Human Fly
cellular ketone metabolic process GO:0042180 84 0.030
regulation of cell migration GO:0030334 219 0.030
cell division GO:0051301 120 0.029
Human
protein polyubiquitination GO:0000209 33 0.029
positive regulation of cell migration GO:0030335 109 0.029
regulation of mitotic cell cycle GO:0007346 126 0.029
heterocycle catabolic process GO:0046700 280 0.028
Human Fly
purine ribonucleoside catabolic process GO:0046130 205 0.028
Human Fly
amide transport GO:0042886 138 0.028
aromatic compound catabolic process GO:0019439 286 0.028
Human Fly
nucleoside phosphate metabolic process GO:0006753 338 0.028
Human Fly
purine ribonucleoside metabolic process GO:0046128 241 0.028
Human Fly
positive regulation of cellular catabolic process GO:0031331 148 0.028
maintenance of location GO:0051235 89 0.028
negative regulation of protein phosphorylation GO:0001933 126 0.028
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.027
Human Fly
purine nucleotide catabolic process GO:0006195 211 0.027
Human Fly
purine nucleoside metabolic process GO:0042278 241 0.027
Human Fly
regulation of cytoplasmic transport GO:1903649 112 0.027
purine nucleoside triphosphate metabolic process GO:0009144 226 0.027
Human Fly
regulation of cellular response to growth factor stimulus GO:0090287 82 0.027
muscle cell differentiation GO:0042692 261 0.027
protein localization to nucleus GO:0034504 121 0.027
regulation of cellular ketone metabolic process GO:0010565 66 0.027
spermatogenesis GO:0007283 284 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.027
ribonucleoside triphosphate catabolic process GO:0009203 199 0.026
Human Fly
organelle localization GO:0051640 179 0.026
synapse organization GO:0050808 125 0.026
Fly
endomembrane system organization GO:0010256 147 0.026
Zebrafish
pallium development GO:0021543 120 0.026
muscle tissue development GO:0060537 308 0.025
leukocyte differentiation GO:0002521 342 0.025
telencephalon development GO:0021537 186 0.025
protein import into nucleus GO:0006606 95 0.025
response to radiation GO:0009314 165 0.025
negative regulation of phosphorylation GO:0042326 166 0.025
positive regulation of nucleotide metabolic process GO:0045981 114 0.025
regulation of protein catabolic process GO:0042176 108 0.025
negative regulation of cell cycle phase transition GO:1901988 48 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
negative regulation of phosphate metabolic process GO:0045936 184 0.024
regionalization GO:0003002 337 0.024
gtp metabolic process GO:0046039 144 0.024
regulation of protein import into nucleus GO:0042306 52 0.024
response to light stimulus GO:0009416 135 0.024
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.024
regulation of defense response GO:0031347 233 0.024
stem cell differentiation GO:0048863 268 0.024
nitrogen compound transport GO:0071705 271 0.024
carbon catabolite regulation of transcription GO:0045990 4 0.024
stem cell maintenance GO:0019827 130 0.024
synaptic transmission GO:0007268 329 0.024
Fly
regulation of mapk cascade GO:0043408 248 0.024
protein localization to membrane GO:0072657 108 0.023
negative regulation of immune system process GO:0002683 209 0.023
microtubule based process GO:0007017 236 0.023
defense response to other organism GO:0098542 197 0.023
hindbrain development GO:0030902 128 0.023
ribonucleotide catabolic process GO:0009261 208 0.023
Human Fly
regulation of cell cycle process GO:0010564 160 0.022
cell type specific apoptotic process GO:0097285 268 0.022
nucleotide catabolic process GO:0009166 217 0.022
Human Fly
modification dependent macromolecule catabolic process GO:0043632 133 0.022
regulation of ras protein signal transduction GO:0046578 114 0.022
negative regulation of phosphorus metabolic process GO:0010563 184 0.022
skeletal muscle organ development GO:0060538 163 0.022
nucleobase containing small molecule metabolic process GO:0055086 352 0.021
Human Fly
regulation of nucleotide catabolic process GO:0030811 122 0.021
regulation of cellular component size GO:0032535 121 0.021
Zebrafish
germ cell development GO:0007281 185 0.021
learning or memory GO:0007611 148 0.021
actin cytoskeleton organization GO:0030036 220 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
Human Fly
spermatid development GO:0007286 108 0.021
negative regulation of cell development GO:0010721 169 0.020
rna processing GO:0006396 105 0.020
regulation of cell cycle GO:0051726 281 0.020
regulation of nucleocytoplasmic transport GO:0046822 73 0.019
positive regulation of protein modification process GO:0031401 299 0.019
endocytosis GO:0006897 168 0.019
nucleoside metabolic process GO:0009116 246 0.019
Human Fly
t cell differentiation GO:0030217 174 0.019
regulation of cytokine production GO:0001817 266 0.019
regulation of secretion GO:0051046 274 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
Human Fly
cerebellum development GO:0021549 77 0.019
regulation of multi organism process GO:0043900 111 0.018
developmental growth involved in morphogenesis GO:0060560 138 0.018
Zebrafish
regulation of transcription factor import into nucleus GO:0042990 24 0.018
metencephalon development GO:0022037 89 0.018
transmission of nerve impulse GO:0019226 76 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
Human Fly
methylation GO:0032259 134 0.018
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.018
dna repair GO:0006281 107 0.018
gene silencing by rna GO:0031047 19 0.018
olfactory learning GO:0008355 2 0.018
epithelial cell migration GO:0010631 63 0.017
ribonucleoside metabolic process GO:0009119 245 0.017
Human Fly
positive regulation of protein catabolic process GO:0045732 60 0.017
negative regulation of cell cycle process GO:0010948 69 0.017
regulation of kinase activity GO:0043549 249 0.017
adaptive immune response GO:0002250 155 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
cellular nitrogen compound catabolic process GO:0044270 280 0.017
Human Fly
purine ribonucleotide metabolic process GO:0009150 290 0.017
Human Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.017
cytokine production GO:0001816 319 0.017
positive regulation of growth GO:0045927 104 0.017
Zebrafish Fly
t cell activation GO:0042110 289 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
Human Fly
nucleoside triphosphate metabolic process GO:0009141 230 0.016
Human Fly
regulation of translation GO:0006417 71 0.016
cellular component assembly involved in morphogenesis GO:0010927 139 0.016
carbon catabolite activation of transcription GO:0045991 4 0.016
digestive system development GO:0055123 200 0.016
axon guidance GO:0007411 141 0.016
cellular homeostasis GO:0019725 240 0.016
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.016
lateral inhibition GO:0046331 1 0.015
neuron migration GO:0001764 122 0.015
stem cell development GO:0048864 219 0.015
protein autophosphorylation GO:0046777 61 0.015
transmembrane transport GO:0055085 412 0.015
macromolecule methylation GO:0043414 120 0.015
posttranscriptional gene silencing GO:0016441 10 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
nucleoside catabolic process GO:0009164 206 0.015
Human Fly
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.015
rna interference GO:0016246 2 0.015
regulation of muscle system process GO:0090257 80 0.015
mitotic cell cycle GO:0000278 195 0.015
Fly
oocyte axis specification GO:0007309 2 0.015
regulation of protein localization to nucleus GO:1900180 60 0.015
locomotory behavior GO:0007626 195 0.015
Fly
lung development GO:0030324 164 0.015
regulation of hormone levels GO:0010817 211 0.015
tissue migration GO:0090130 68 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
Human Fly
cell growth GO:0016049 130 0.015
Zebrafish
regulation of ras gtpase activity GO:0032318 88 0.015
negative regulation of gene expression epigenetic GO:0045814 15 0.015
lymphocyte mediated immunity GO:0002449 139 0.015
positive regulation of cytoplasmic transport GO:1903651 40 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
ameboidal type cell migration GO:0001667 128 0.014
spermatid differentiation GO:0048515 115 0.014
negative regulation of molecular function GO:0044092 258 0.014
peptide transport GO:0015833 133 0.014
regulation of secretion by cell GO:1903530 249 0.014
neuron projection guidance GO:0097485 141 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
Human Fly
mitotic cell cycle checkpoint GO:0007093 31 0.014
regulation of anatomical structure size GO:0090066 178 0.014
Zebrafish
development of primary sexual characteristics GO:0045137 143 0.014
learning GO:0007612 98 0.014
myeloid cell homeostasis GO:0002262 114 0.014
positive regulation of hydrolase activity GO:0051345 148 0.014
protein k48 linked ubiquitination GO:0070936 7 0.014
positive regulation of nucleotide catabolic process GO:0030813 88 0.014
cellularization GO:0007349 1 0.014
lipid localization GO:0010876 126 0.014
digestive tract development GO:0048565 190 0.014
regulation of protein targeting GO:1903533 61 0.014
negative regulation of nervous system development GO:0051961 156 0.014
Fly
chromatin silencing GO:0006342 15 0.014
response to inorganic substance GO:0010035 96 0.013
hormone secretion GO:0046879 128 0.013
divalent metal ion transport GO:0070838 172 0.013
regulation of actin filament based process GO:0032970 99 0.013
regulation of cellular response to stress GO:0080135 159 0.013
exocytosis GO:0006887 121 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
Human Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.013
respiratory system development GO:0060541 190 0.013
anatomical structure homeostasis GO:0060249 145 0.013
actin filament organization GO:0007015 113 0.013
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.013
gtp catabolic process GO:0006184 143 0.013
regulation of cell size GO:0008361 72 0.013
Zebrafish
cognition GO:0050890 149 0.013
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.013
mitotic cell cycle process GO:1903047 159 0.013
Fly
regulation of mitotic cell cycle phase transition GO:1901990 73 0.013
cation transport GO:0006812 399 0.013
lymphocyte differentiation GO:0030098 242 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
regulation of cell activation GO:0050865 289 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
Zebrafish Fly
regulation of system process GO:0044057 200 0.013
adult behavior GO:0030534 135 0.012
peptide hormone secretion GO:0030072 109 0.012
skeletal system development GO:0001501 356 0.012
positive regulation of nucleoside metabolic process GO:0045979 91 0.012
jnk cascade GO:0007254 72 0.012
negative regulation of mapk cascade GO:0043409 65 0.012
regulation of membrane potential GO:0042391 192 0.012
regulation of t cell activation GO:0050863 170 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
regulation of hydrolase activity GO:0051336 246 0.012
nuclear division GO:0000280 158 0.012
Fly
digestive tract morphogenesis GO:0048546 147 0.012
response to insulin GO:0032868 100 0.012
regulation of cell cycle phase transition GO:1901987 77 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
positive regulation of cellular component biogenesis GO:0044089 94 0.012
Fly
regulation of chromosome organization GO:0033044 83 0.012
cell adhesion GO:0007155 329 0.012
positive regulation of cell motility GO:2000147 116 0.012
cell fate commitment GO:0045165 210 0.012
mrna metabolic process GO:0016071 84 0.012
respiratory tube development GO:0030323 167 0.011
stress activated protein kinase signaling cascade GO:0031098 81 0.011
plasma membrane organization GO:0007009 90 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
response to peptide GO:1901652 136 0.011
protein modification by small protein removal GO:0070646 21 0.011
cerebral cortex development GO:0021987 86 0.011
blood vessel morphogenesis GO:0048514 285 0.011
meiotic nuclear division GO:0007126 115 0.011
response to temperature stimulus GO:0009266 55 0.011
neuron apoptotic process GO:0051402 142 0.011
response to extracellular stimulus GO:0009991 127 0.011
wnt signaling pathway GO:0016055 188 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
Human Fly
developmental cell growth GO:0048588 84 0.011
Zebrafish
cell cycle g1 s phase transition GO:0044843 57 0.011
cation transmembrane transport GO:0098655 266 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
meiotic cell cycle GO:0051321 122 0.011
divalent inorganic cation transport GO:0072511 178 0.011
regulation of cell projection organization GO:0031344 206 0.011
Zebrafish Fly
developmental maturation GO:0021700 193 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
cellular response to external stimulus GO:0071496 88 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
regulation of histone modification GO:0031056 56 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
epithelium migration GO:0090132 63 0.011
bmp signaling pathway GO:0030509 93 0.011
purine containing compound catabolic process GO:0072523 213 0.011
Human Fly
innate immune response GO:0045087 157 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
positive regulation of neuron differentiation GO:0045666 141 0.011
Zebrafish Fly
cellular response to nutrient levels GO:0031669 64 0.011
gland development GO:0048732 330 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.010
neuronal action potential GO:0019228 54 0.010
hyperosmotic response GO:0006972 4 0.010
regulation of innate immune response GO:0045088 91 0.010
regulation of chromatin modification GO:1903308 57 0.010
oocyte construction GO:0007308 2 0.010
leukocyte mediated immunity GO:0002443 174 0.010
gonad development GO:0008406 141 0.010
positive regulation of mapk cascade GO:0043410 170 0.010
regulation of dna recombination GO:0000018 34 0.010
guanosine containing compound metabolic process GO:1901068 144 0.010
negative regulation of neuron death GO:1901215 98 0.010
positive regulation of protein transport GO:0051222 93 0.010
regulation of neuron differentiation GO:0045664 281 0.010
Zebrafish Fly
regulation of lymphocyte mediated immunity GO:0002706 84 0.010
regulation of muscle tissue development GO:1901861 97 0.010
regulation of epithelial cell migration GO:0010632 35 0.010
cellular chemical homeostasis GO:0055082 215 0.010
positive regulation of innate immune response GO:0045089 80 0.010

Spast disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.075
Human
nervous system disease DOID:863 0 0.075
Human
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
central nervous system disease DOID:331 0 0.010
Human
neurodegenerative disease DOID:1289 0 0.010