Mus musculus

49 known processes

Sphk2

sphingosine kinase 2

(Aliases: MGC102297,C76851)

Sphk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular ketone metabolic process GO:0010565 66 0.261
cellular ketone metabolic process GO:0042180 84 0.194
lipid biosynthetic process GO:0008610 179 0.190
fatty acid metabolic process GO:0006631 121 0.150
monocarboxylic acid metabolic process GO:0032787 191 0.129
regulation of intracellular transport GO:0032386 159 0.123
cellular amino acid metabolic process GO:0006520 103 0.121
purine ribonucleoside catabolic process GO:0046130 205 0.116
regulation of kinase activity GO:0043549 249 0.111
acetylcholine transport GO:0015870 2 0.108
Worm
positive regulation of protein phosphorylation GO:0001934 242 0.104
regulation of protein transport GO:0051223 163 0.101
purine nucleotide metabolic process GO:0006163 302 0.100
nitrogen compound transport GO:0071705 271 0.099
Worm
immune effector process GO:0002252 321 0.099
carbohydrate metabolic process GO:0005975 230 0.097
nucleoside phosphate metabolic process GO:0006753 338 0.096
organic acid transport GO:0015849 101 0.095
heterocycle catabolic process GO:0046700 280 0.094
response to organonitrogen compound GO:0010243 246 0.092
germ cell development GO:0007281 185 0.092
regulation of cell cycle GO:0051726 281 0.092
ribonucleoside catabolic process GO:0042454 206 0.091
negative regulation of protein metabolic process GO:0051248 282 0.090
regulation of cellular amine metabolic process GO:0033238 20 0.088
cytoplasmic transport GO:0016482 234 0.087
regulation of cellular amino acid metabolic process GO:0006521 5 0.081
regulation of secretion by cell GO:1903530 249 0.081
Worm
purine ribonucleotide catabolic process GO:0009154 208 0.080
regulation of cellular component biogenesis GO:0044087 181 0.080
carboxylic acid transport GO:0046942 100 0.080
nucleobase containing small molecule metabolic process GO:0055086 352 0.080
cellular amine metabolic process GO:0044106 44 0.080
cation transport GO:0006812 399 0.079
Worm
purine ribonucleoside metabolic process GO:0046128 241 0.079
defense response to other organism GO:0098542 197 0.079
regulation of cell projection organization GO:0031344 206 0.077
nucleoside triphosphate catabolic process GO:0009143 205 0.076
purine nucleotide catabolic process GO:0006195 211 0.076
intracellular protein transport GO:0006886 204 0.076
aromatic compound catabolic process GO:0019439 286 0.076
ribonucleotide catabolic process GO:0009261 208 0.076
cytokine production GO:0001816 319 0.074
Mouse
protein catabolic process GO:0030163 221 0.074
nucleoside triphosphate metabolic process GO:0009141 230 0.073
regulation of protein kinase activity GO:0045859 232 0.072
transmembrane transport GO:0055085 412 0.072
cellular macromolecule catabolic process GO:0044265 206 0.072
ribonucleoside triphosphate catabolic process GO:0009203 199 0.071
negative regulation of molecular function GO:0044092 258 0.071
positive regulation of protein modification process GO:0031401 299 0.071
positive regulation of cellular catabolic process GO:0031331 148 0.069
nucleotide metabolic process GO:0009117 332 0.069
purine nucleoside metabolic process GO:0042278 241 0.069
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.068
regulation of secretion GO:0051046 274 0.068
Worm
positive regulation of cellular amine metabolic process GO:0033240 5 0.068
negative regulation of immune system process GO:0002683 209 0.067
protein localization to organelle GO:0033365 185 0.066
response to peptide GO:1901652 136 0.066
regulation of transferase activity GO:0051338 263 0.065
macromolecule catabolic process GO:0009057 281 0.065
ribose phosphate metabolic process GO:0019693 291 0.063
nucleotide catabolic process GO:0009166 217 0.062
organic acid biosynthetic process GO:0016053 86 0.062
cellular lipid metabolic process GO:0044255 323 0.062
leukocyte mediated immunity GO:0002443 174 0.061
protein modification by small protein conjugation or removal GO:0070647 207 0.059
positive regulation of cell motility GO:2000147 116 0.059
ribonucleotide metabolic process GO:0009259 291 0.058
regulation of protein localization GO:0032880 231 0.058
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.058
purine containing compound catabolic process GO:0072523 213 0.058
regulation of cell migration GO:0030334 219 0.058
regulation of peptide transport GO:0090087 91 0.058
protein modification by small protein conjugation GO:0032446 187 0.057
nucleoside catabolic process GO:0009164 206 0.057
regulation of cellular catabolic process GO:0031329 242 0.056
microtubule based process GO:0007017 236 0.055
regulation of intracellular protein transport GO:0033157 82 0.055
ribonucleoside triphosphate metabolic process GO:0009199 220 0.055
purine containing compound metabolic process GO:0072521 311 0.055
regulation of cell motility GO:2000145 236 0.054
small molecule biosynthetic process GO:0044283 132 0.053
mapk cascade GO:0000165 281 0.053
carbohydrate derivative catabolic process GO:1901136 231 0.052
membrane organization GO:0061024 245 0.052
peptidyl amino acid modification GO:0018193 336 0.052
regulation of actin filament based process GO:0032970 99 0.050
purine ribonucleotide metabolic process GO:0009150 290 0.049
amine metabolic process GO:0009308 45 0.049
membrane lipid metabolic process GO:0006643 53 0.049
regulation of establishment of protein localization GO:0070201 181 0.048
organic cyclic compound catabolic process GO:1901361 295 0.048
locomotory behavior GO:0007626 195 0.048
Fly
regulation of t cell activation GO:0050863 170 0.048
regulation of cytokine production GO:0001817 266 0.047
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 203 0.046
regulation of vesicle mediated transport GO:0060627 139 0.046
ion transmembrane transport GO:0034220 361 0.044
spermatogenesis GO:0007283 284 0.044
t cell activation GO:0042110 289 0.044
positive regulation of transferase activity GO:0051347 167 0.044
negative regulation of phosphorus metabolic process GO:0010563 184 0.044
ras protein signal transduction GO:0007265 77 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
cellular homeostasis GO:0019725 240 0.043
carbohydrate biosynthetic process GO:0016051 74 0.042
positive regulation of intracellular transport GO:0032388 70 0.042
response to insulin GO:0032868 100 0.042
regulation of neuron projection development GO:0010975 169 0.042
protein methylation GO:0006479 81 0.042
regulation of neuron differentiation GO:0045664 281 0.042
nucleoside phosphate catabolic process GO:1901292 222 0.041
establishment of protein localization to organelle GO:0072594 118 0.041
cellular carbohydrate metabolic process GO:0044262 119 0.041
carboxylic acid biosynthetic process GO:0046394 86 0.040
lymphocyte mediated immunity GO:0002449 139 0.040
synaptic transmission GO:0007268 329 0.040
Worm
small gtpase mediated signal transduction GO:0007264 97 0.040
positive regulation of kinase activity GO:0033674 155 0.040
adaptive immune response GO:0002250 155 0.039
response to organic cyclic compound GO:0014070 198 0.039
acetate ester transport GO:1901374 2 0.039
Worm
telencephalon development GO:0021537 186 0.039
glycosyl compound metabolic process GO:1901657 246 0.039
positive regulation of protein transport GO:0051222 93 0.038
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.038
insulin receptor signaling pathway GO:0008286 49 0.038
negative regulation of phosphate metabolic process GO:0045936 184 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.038
protein ubiquitination GO:0016567 171 0.038
maintenance of location GO:0051235 89 0.038
ribonucleoside metabolic process GO:0009119 245 0.038
regulation of mapk cascade GO:0043408 248 0.037
nucleoside metabolic process GO:0009116 246 0.037
leukocyte differentiation GO:0002521 342 0.037
regulation of protein serine threonine kinase activity GO:0071900 157 0.037
endocytosis GO:0006897 168 0.037
organic anion transport GO:0015711 137 0.037
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.036
striated muscle tissue development GO:0014706 293 0.036
cell type specific apoptotic process GO:0097285 268 0.036
monocarboxylic acid biosynthetic process GO:0072330 61 0.036
neuronal action potential GO:0019228 54 0.035
nucleocytoplasmic transport GO:0006913 139 0.035
regulation of cytoplasmic transport GO:1903649 112 0.035
glycosyl compound catabolic process GO:1901658 206 0.035
reactive oxygen species biosynthetic process GO:1903409 8 0.035
positive regulation of cell migration GO:0030335 109 0.035
response to inorganic substance GO:0010035 96 0.034
cation homeostasis GO:0055080 212 0.033
respiratory system development GO:0060541 190 0.033
regulation of lipid metabolic process GO:0019216 118 0.033
purine nucleoside catabolic process GO:0006152 205 0.032
positive regulation of protein kinase activity GO:0045860 144 0.032
energy derivation by oxidation of organic compounds GO:0015980 77 0.032
cellular nitrogen compound catabolic process GO:0044270 280 0.032
adult behavior GO:0030534 135 0.032
Fly
regulation of adaptive immune response GO:0002819 90 0.031
negative regulation of cellular amine metabolic process GO:0033239 1 0.031
regulation of protein targeting GO:1903533 61 0.031
regulation of lymphocyte activation GO:0051249 240 0.031
cellular protein catabolic process GO:0044257 155 0.031
negative regulation of cellular component organization GO:0051129 194 0.031
amide transport GO:0042886 138 0.031
alcohol metabolic process GO:0006066 116 0.031
protein localization to nucleus GO:0034504 121 0.030
apoptotic signaling pathway GO:0097190 306 0.030
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.030
spermatid development GO:0007286 108 0.030
negative regulation of phosphorylation GO:0042326 166 0.030
response to oxidative stress GO:0006979 123 0.030
long chain fatty acid metabolic process GO:0001676 26 0.030
regulation of cell activation GO:0050865 289 0.029
single organismal cell cell adhesion GO:0016337 131 0.029
regulation of lymphocyte differentiation GO:0045619 107 0.029
regulation of nucleotide catabolic process GO:0030811 122 0.029
reactive oxygen species metabolic process GO:0072593 84 0.029
fatty acid derivative metabolic process GO:1901568 33 0.029
peptide transport GO:0015833 133 0.029
regulation of cellular response to stress GO:0080135 159 0.029
regionalization GO:0003002 337 0.028
metal ion homeostasis GO:0055065 189 0.028
lipid catabolic process GO:0016042 69 0.028
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.028
fatty acid biosynthetic process GO:0006633 41 0.028
cellular response to organonitrogen compound GO:0071417 145 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.027
glycerolipid metabolic process GO:0046486 122 0.027
negative regulation of cellular protein metabolic process GO:0032269 247 0.027
negative regulation of protein modification process GO:0031400 163 0.027
regulation of reactive oxygen species metabolic process GO:2000377 40 0.027
cell growth GO:0016049 130 0.027
protein targeting GO:0006605 143 0.027
cellular chemical homeostasis GO:0055082 215 0.027
oxidation reduction process GO:0055114 342 0.027
transmission of nerve impulse GO:0019226 76 0.027
regulation of hydrolase activity GO:0051336 246 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.027
regulation of homeostatic process GO:0032844 182 0.027
protein alkylation GO:0008213 81 0.026
neurotransmitter transport GO:0006836 76 0.026
Worm
regulation of protein complex assembly GO:0043254 83 0.026
protein processing GO:0016485 163 0.026
organonitrogen compound catabolic process GO:1901565 264 0.026
cellular response to peptide GO:1901653 92 0.026
cellular response to cytokine stimulus GO:0071345 189 0.026
positive regulation of intracellular protein transport GO:0090316 42 0.026
glucose metabolic process GO:0006006 92 0.026
regulation of lymphocyte mediated immunity GO:0002706 84 0.026
muscle system process GO:0003012 141 0.026
i kappab kinase nf kappab signaling GO:0007249 85 0.026
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.026
rho protein signal transduction GO:0007266 32 0.025
t cell differentiation GO:0030217 174 0.025
stem cell differentiation GO:0048863 268 0.025
macromolecule glycosylation GO:0043413 55 0.025
positive regulation of lipid metabolic process GO:0045834 40 0.025
energy reserve metabolic process GO:0006112 39 0.025
cellular lipid catabolic process GO:0044242 52 0.025
regulation of neurotransmitter levels GO:0001505 87 0.025
Worm
cellular protein complex assembly GO:0043623 116 0.025
positive regulation of cytokine production GO:0001819 174 0.024
multicellular organismal signaling GO:0035637 91 0.024
peptidyl serine phosphorylation GO:0018105 74 0.024
blood vessel morphogenesis GO:0048514 285 0.024
lipid modification GO:0030258 65 0.024
negative regulation of nervous system development GO:0051961 156 0.024
modification dependent macromolecule catabolic process GO:0043632 133 0.024
positive regulation of cellular component biogenesis GO:0044089 94 0.024
ossification GO:0001503 216 0.024
cellular response to extracellular stimulus GO:0031668 81 0.023
neuron death GO:0070997 154 0.023
proteasomal protein catabolic process GO:0010498 98 0.023
leukocyte proliferation GO:0070661 172 0.023
methylation GO:0032259 134 0.023
phagocytosis GO:0006909 66 0.023
cognition GO:0050890 149 0.023
forebrain development GO:0030900 302 0.023
regulation of organelle organization GO:0033043 289 0.023
gtp catabolic process GO:0006184 143 0.023
skeletal system development GO:0001501 356 0.023
regulation of system process GO:0044057 200 0.023
actin polymerization or depolymerization GO:0008154 54 0.023
generation of precursor metabolites and energy GO:0006091 103 0.023
nuclear import GO:0051170 95 0.023
cell adhesion GO:0007155 329 0.022
regulation of protein ubiquitination GO:0031396 52 0.022
regulation of protein catabolic process GO:0042176 108 0.022
hexose metabolic process GO:0019318 98 0.022
central nervous system neuron differentiation GO:0021953 162 0.022
cellular response to peptide hormone stimulus GO:0071375 92 0.022
anion transport GO:0006820 177 0.022
sensory system development GO:0048880 3 0.022
metencephalon development GO:0022037 89 0.022
microtubule cytoskeleton organization GO:0000226 157 0.022
chromatin modification GO:0016568 187 0.022
macromolecule methylation GO:0043414 120 0.022
polysaccharide metabolic process GO:0005976 39 0.022
spermatid differentiation GO:0048515 115 0.022
response to peptide hormone GO:0043434 127 0.022
neuron apoptotic process GO:0051402 142 0.022
positive regulation of cell activation GO:0050867 158 0.022
actin filament organization GO:0007015 113 0.022
sequestering of metal ion GO:0051238 19 0.022
cytokine mediated signaling pathway GO:0019221 115 0.021
modification dependent protein catabolic process GO:0019941 133 0.021
inflammatory response GO:0006954 244 0.021
Mouse
positive regulation of cellular protein catabolic process GO:1903364 34 0.021
protein maturation GO:0051604 176 0.021
regulation of ras protein signal transduction GO:0046578 114 0.021
regulation of muscle system process GO:0090257 80 0.021
regulation of actin cytoskeleton organization GO:0032956 84 0.020
response to monosaccharide GO:0034284 67 0.020
cell substrate adhesion GO:0031589 130 0.020
organophosphate catabolic process GO:0046434 232 0.020
protein import GO:0017038 101 0.020
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.020
multi multicellular organism process GO:0044706 109 0.020
Fly
single organism cell adhesion GO:0098602 156 0.020
lipid transport GO:0006869 98 0.020
regulation of cytoskeleton organization GO:0051493 122 0.020
response to temperature stimulus GO:0009266 55 0.020
regulation of leukocyte mediated immunity GO:0002703 104 0.020
response to extracellular stimulus GO:0009991 127 0.020
regulation of cellular protein catabolic process GO:1903362 61 0.019
muscle tissue development GO:0060537 308 0.019
regulation of nucleocytoplasmic transport GO:0046822 73 0.019
positive regulation of nucleotide catabolic process GO:0030813 88 0.019
peptidyl tyrosine phosphorylation GO:0018108 143 0.019
protein glycosylation GO:0006486 55 0.019
fat soluble vitamin biosynthetic process GO:0042362 4 0.019
carbohydrate derivative biosynthetic process GO:1901137 183 0.019
regulation of t cell differentiation GO:0045580 83 0.019
positive regulation of nervous system development GO:0051962 221 0.019
glycosylation GO:0070085 62 0.019
response to reactive oxygen species GO:0000302 56 0.019
sequestering of calcium ion GO:0051208 18 0.019
engulfment of apoptotic cell GO:0043652 3 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
regulation of carbohydrate metabolic process GO:0006109 75 0.018
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.018
mitotic cell cycle GO:0000278 195 0.018
regulation of cell cycle process GO:0010564 160 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
icosanoid metabolic process GO:0006690 33 0.018
response to acid chemical GO:0001101 111 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
regulation of carbohydrate biosynthetic process GO:0043255 40 0.018
positive regulation of secretion GO:0051047 130 0.018
Worm
organelle fission GO:0048285 170 0.018
response to molecule of bacterial origin GO:0002237 143 0.018
regulation of innate immune response GO:0045088 91 0.018
cation transmembrane transport GO:0098655 266 0.018
regulation of lipid biosynthetic process GO:0046890 54 0.018
protein localization to membrane GO:0072657 108 0.018
glial cell differentiation GO:0010001 131 0.018
angiogenesis GO:0001525 201 0.018
establishment of protein localization to membrane GO:0090150 54 0.018
positive regulation of cytoplasmic transport GO:1903651 40 0.018
unsaturated fatty acid metabolic process GO:0033559 31 0.017
carbohydrate homeostasis GO:0033500 128 0.017
defense response to bacterium GO:0042742 119 0.017
glycogen metabolic process GO:0005977 32 0.017
lipid localization GO:0010876 126 0.017
negative regulation of synapse assembly GO:0051964 3 0.017
myeloid cell differentiation GO:0030099 233 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
regulation of protein import into nucleus GO:0042306 52 0.017
regulation of ras gtpase activity GO:0032318 88 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.017
cellular ion homeostasis GO:0006873 165 0.017
regulation of ion transport GO:0043269 215 0.017
Worm
cellular polysaccharide metabolic process GO:0044264 38 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
positive regulation of secretion by cell GO:1903532 114 0.017
Worm
positive regulation of gtpase activity GO:0043547 85 0.017
positive regulation of nucleoside metabolic process GO:0045979 91 0.017
actin cytoskeleton organization GO:0030036 220 0.017
regulation of leukocyte proliferation GO:0070663 121 0.017
innate immune response GO:0045087 157 0.017
inorganic ion transmembrane transport GO:0098660 234 0.017
actin filament polymerization GO:0030041 44 0.017
sodium ion transport GO:0006814 73 0.017
regulation of cell growth GO:0001558 91 0.017
regulation of mitotic cell cycle GO:0007346 126 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.016
regulation of proteolysis GO:0030162 164 0.016
acylglycerol metabolic process GO:0006639 55 0.016
muscle cell differentiation GO:0042692 261 0.016
monocarboxylic acid transport GO:0015718 44 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
response to lipopolysaccharide GO:0032496 128 0.016
bone development GO:0060348 120 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
negative regulation of cell projection organization GO:0031345 56 0.016
anion transmembrane transport GO:0098656 71 0.016
oocyte development GO:0048599 33 0.016
positive regulation of neuron differentiation GO:0045666 141 0.016
regulation of stress activated mapk cascade GO:0032872 69 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
single organism nuclear import GO:1902593 95 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
b cell mediated immunity GO:0019724 71 0.016
camera type eye development GO:0043010 266 0.016
monosaccharide metabolic process GO:0005996 106 0.016
cellular response to lipid GO:0071396 145 0.016
negative regulation of cell motility GO:2000146 61 0.016
positive regulation of lymphocyte activation GO:0051251 140 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
positive regulation of cell projection organization GO:0031346 95 0.016
sensory organ morphogenesis GO:0090596 242 0.016
stress activated protein kinase signaling cascade GO:0031098 81 0.016
nuclear transport GO:0051169 139 0.016
ameboidal type cell migration GO:0001667 128 0.016
neuron migration GO:0001764 122 0.016
developmental maturation GO:0021700 193 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
negative regulation of cell development GO:0010721 169 0.015
glucose homeostasis GO:0042593 128 0.015
translation GO:0006412 93 0.015
regulation of leukocyte differentiation GO:1902105 159 0.015
gliogenesis GO:0042063 141 0.015
regulation of cellular component size GO:0032535 121 0.015
establishment or maintenance of cell polarity GO:0007163 86 0.015
epidermis development GO:0008544 187 0.015
acetylcholine secretion neurotransmission GO:0014055 2 0.015
Worm
pallium development GO:0021543 120 0.015
circadian rhythm GO:0007623 114 0.015
regulation of anatomical structure size GO:0090066 178 0.015
positive regulation of cytoskeleton organization GO:0051495 49 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.015
cerebellum development GO:0021549 77 0.015
positive regulation of defense response GO:0031349 124 0.015
regulation of membrane potential GO:0042391 192 0.015
cellular response to starvation GO:0009267 57 0.015
regulation of endocytosis GO:0030100 69 0.015
t cell proliferation GO:0042098 120 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
fatty acid transmembrane transport GO:1902001 1 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
establishment of organelle localization GO:0051656 122 0.015
protein localization to plasma membrane GO:0072659 57 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
positive regulation of gtp catabolic process GO:0033126 85 0.015
negative regulation of cell proliferation GO:0008285 296 0.014
small molecule catabolic process GO:0044282 71 0.014
cytokine biosynthetic process GO:0042089 68 0.014
hormone secretion GO:0046879 128 0.014
peptide hormone secretion GO:0030072 109 0.014
peptidyl serine modification GO:0018209 83 0.014
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.014
peptidyl tyrosine modification GO:0018212 145 0.014
monovalent inorganic cation homeostasis GO:0055067 33 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
regulation of translation GO:0006417 71 0.014
positive regulation of protein catabolic process GO:0045732 60 0.014
regulation of exocytosis GO:0017157 61 0.014
negative regulation of leukocyte differentiation GO:1902106 51 0.014
lymphocyte differentiation GO:0030098 242 0.014
peptidyl threonine phosphorylation GO:0018107 31 0.014
positive regulation of rho gtpase activity GO:0032321 41 0.014
skin development GO:0043588 220 0.014
ubiquitin dependent protein catabolic process GO:0006511 129 0.014
cell division GO:0051301 120 0.014
regulation of glucose metabolic process GO:0010906 60 0.014
regulation of protein localization to nucleus GO:1900180 60 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
negative regulation of proteolysis GO:0045861 74 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.014
female gamete generation GO:0007292 74 0.014
positive regulation of immune effector process GO:0002699 107 0.014
hindbrain development GO:0030902 128 0.014
action potential GO:0001508 78 0.014
positive regulation of ion transport GO:0043270 65 0.013
Worm
multicellular organismal homeostasis GO:0048871 164 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
blood circulation GO:0008015 195 0.013
positive regulation of leukocyte mediated immunity GO:0002705 70 0.013
very long chain fatty acid catabolic process GO:0042760 2 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
learning or memory GO:0007611 148 0.013
respiratory tube development GO:0030323 167 0.013
immunoglobulin mediated immune response GO:0016064 69 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
nucleoside monophosphate catabolic process GO:0009125 59 0.013
cellular glucan metabolic process GO:0006073 32 0.013
negative regulation of t cell activation GO:0050868 65 0.013
learning GO:0007612 98 0.013
plasma membrane organization GO:0007009 90 0.013
positive regulation of t cell activation GO:0050870 101 0.013
endomembrane system organization GO:0010256 147 0.013
triglyceride metabolic process GO:0006641 51 0.013
chromatin organization GO:0006325 206 0.013
positive regulation of organelle organization GO:0010638 128 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.013
defecation GO:0030421 1 0.013
cerebellar cortex development GO:0021695 48 0.013
cellular response to insulin stimulus GO:0032869 78 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
lymphocyte proliferation GO:0046651 164 0.013
hexose biosynthetic process GO:0019319 39 0.013
hexose transport GO:0008645 56 0.013
response to growth factor GO:0070848 198 0.013
negative regulation of cell migration GO:0030336 59 0.013
positive regulation of protein ubiquitination GO:0031398 27 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
protein polymerization GO:0051258 57 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
male gamete generation GO:0048232 285 0.013
neutral lipid metabolic process GO:0006638 57 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
exocytosis GO:0006887 121 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
atp catabolic process GO:0006200 55 0.012
monosaccharide transport GO:0015749 58 0.012
dendrite development GO:0016358 115 0.012
activation of immune response GO:0002253 138 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
regulation of metal ion transport GO:0010959 106 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
epithelial cell proliferation GO:0050673 174 0.012
regulation of feeding behavior GO:0060259 3 0.012
oocyte construction GO:0007308 2 0.012
regulation of protein maturation GO:1903317 96 0.012
embryonic placenta development GO:0001892 98 0.012

Sphk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.097
nervous system disease DOID:863 0 0.097
central nervous system disease DOID:331 0 0.076
musculoskeletal system disease DOID:17 0 0.032
neurodegenerative disease DOID:1289 0 0.021
brain disease DOID:936 0 0.015
sensory system disease DOID:0050155 0 0.012