Mus musculus

68 known processes

Spib

Spi-B transcription factor (Spi-1/PU.1 related)

(Aliases: Spi-B)

Spib biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune response activating signal transduction GO:0002757 116 0.784
lymphocyte differentiation GO:0030098 242 0.779
Mouse
t cell activation GO:0042110 289 0.762
regulation of lymphocyte activation GO:0051249 240 0.727
regulation of cell activation GO:0050865 289 0.688
cytokine production GO:0001816 319 0.678
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.661
inflammatory response GO:0006954 244 0.635
leukocyte proliferation GO:0070661 172 0.624
defense response to other organism GO:0098542 197 0.623
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.598
cellular ion homeostasis GO:0006873 165 0.579
regulation of b cell proliferation GO:0030888 39 0.570
activation of immune response GO:0002253 138 0.554
negative regulation of cell activation GO:0050866 111 0.546
positive regulation of cell activation GO:0050867 158 0.541
response to molecule of bacterial origin GO:0002237 143 0.535
innate immune response GO:0045087 157 0.535
cation homeostasis GO:0055080 212 0.529
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.527
b cell proliferation GO:0042100 53 0.524
myeloid leukocyte activation GO:0002274 83 0.502
Mouse
positive regulation of t cell activation GO:0050870 101 0.470
cytokine secretion GO:0050663 72 0.456
forebrain development GO:0030900 302 0.445
cellular calcium ion homeostasis GO:0006874 119 0.440
negative regulation of synapse assembly GO:0051964 3 0.439
cellular chemical homeostasis GO:0055082 215 0.438
leukocyte differentiation GO:0002521 342 0.436
regulation of homeostatic process GO:0032844 182 0.418
fatty acid biosynthetic process GO:0006633 41 0.410
leukocyte migration GO:0050900 124 0.399
regulation of cell motility GO:2000145 236 0.386
negative regulation of defense response GO:0031348 77 0.385
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.383
t cell differentiation GO:0030217 174 0.383
g protein coupled receptor signaling pathway GO:0007186 243 0.374
regulation of leukocyte proliferation GO:0070663 121 0.373
cell adhesion GO:0007155 329 0.372
positive regulation of cytokine production GO:0001819 174 0.367
dendritic cell differentiation GO:0097028 26 0.362
Mouse
adaptive immune response GO:0002250 155 0.358
positive regulation of cell development GO:0010720 237 0.355
microglial cell activation involved in immune response GO:0002282 1 0.352
negative regulation of cell proliferation GO:0008285 296 0.350
myeloid cell differentiation GO:0030099 233 0.349
cellular homeostasis GO:0019725 240 0.340
axonogenesis GO:0007409 274 0.337
cellular divalent inorganic cation homeostasis GO:0072503 127 0.332
regulation of map kinase activity GO:0043405 120 0.329
neuron projection guidance GO:0097485 141 0.329
regulation of organelle organization GO:0033043 289 0.319
divalent inorganic cation homeostasis GO:0072507 138 0.316
positive regulation of nervous system development GO:0051962 221 0.308
t cell proliferation GO:0042098 120 0.302
regulation of cytokine production GO:0001817 266 0.297
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.296
mast cell degranulation GO:0043303 19 0.295
regulation of t cell activation GO:0050863 170 0.293
regulation of ion homeostasis GO:2000021 64 0.291
ras protein signal transduction GO:0007265 77 0.288
negative regulation of immune system process GO:0002683 209 0.286
regulation of mast cell activation GO:0033003 21 0.281
cerebral cortex development GO:0021987 86 0.281
immune effector process GO:0002252 321 0.280
negative regulation of lymphocyte activation GO:0051250 91 0.277
immune response regulating signaling pathway GO:0002764 125 0.273
maintenance of location GO:0051235 89 0.271
positive regulation of cytokine biosynthetic process GO:0042108 40 0.270
lymphocyte proliferation GO:0046651 164 0.269
regulation of protein serine threonine kinase activity GO:0071900 157 0.269
positive regulation of homeostatic process GO:0032846 64 0.266
regulation of anatomical structure size GO:0090066 178 0.266
positive regulation of secretion GO:0051047 130 0.261
regulation of secretion GO:0051046 274 0.261
chemotaxis GO:0006935 247 0.260
activation of innate immune response GO:0002218 56 0.259
regulation of membrane potential GO:0042391 192 0.253
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.252
multicellular organismal homeostasis GO:0048871 164 0.248
sequestering of calcium ion GO:0051208 18 0.248
cytosolic calcium ion homeostasis GO:0051480 70 0.247
lymphocyte apoptotic process GO:0070227 54 0.237
olfactory learning GO:0008355 2 0.235
activation of mapk activity GO:0000187 59 0.233
regulation of response to wounding GO:1903034 189 0.230
single organismal cell cell adhesion GO:0016337 131 0.229
regulation of neuron projection development GO:0010975 169 0.228
actin filament organization GO:0007015 113 0.225
cellular metal ion homeostasis GO:0006875 151 0.225
regulation of mapk cascade GO:0043408 248 0.224
regulation of secretion by cell GO:1903530 249 0.224
antigen receptor mediated signaling pathway GO:0050851 64 0.224
regulation of lymphocyte proliferation GO:0050670 117 0.223
positive regulation of t cell differentiation GO:0045582 52 0.223
helper t cell chemotaxis GO:0035704 1 0.220
regulation of cellular component size GO:0032535 121 0.220
heart morphogenesis GO:0003007 178 0.219
regulation of eosinophil degranulation GO:0043309 1 0.217
regulation of defense response GO:0031347 233 0.214
b cell homeostasis GO:0001782 34 0.212
alpha beta t cell activation GO:0046631 91 0.211
chemokine mediated signaling pathway GO:0070098 17 0.211
metal ion homeostasis GO:0055065 189 0.210
exocytosis GO:0006887 121 0.209
actin polymerization or depolymerization GO:0008154 54 0.207
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.205
bone resorption GO:0045453 38 0.205
regulation of innate immune response GO:0045088 91 0.203
positive regulation of innate immune response GO:0045089 80 0.203
regulation of cell adhesion GO:0030155 154 0.203
glial cell differentiation GO:0010001 131 0.202
regulation of cellular component biogenesis GO:0044087 181 0.202
leukocyte chemotaxis GO:0030595 69 0.196
granulocyte migration GO:0097530 43 0.195
negative regulation of lymphocyte proliferation GO:0050672 45 0.192
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.191
eosinophil activation GO:0043307 1 0.191
axon guidance GO:0007411 141 0.188
regulation of blood coagulation GO:0030193 28 0.187
regulation of leukocyte differentiation GO:1902105 159 0.187
Zebrafish
platelet activation GO:0030168 40 0.185
negative regulation of eosinophil degranulation GO:0043310 1 0.184
cation transport GO:0006812 399 0.183
positive regulation of protein secretion GO:0050714 52 0.183
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.183
tissue remodeling GO:0048771 102 0.182
nephric duct formation GO:0072179 4 0.178
positive regulation of cell migration GO:0030335 109 0.177
calcium ion transport into cytosol GO:0060402 48 0.176
action potential GO:0001508 78 0.176
positive regulation of secretion by cell GO:1903532 114 0.175
interferon gamma production GO:0032609 67 0.174
membrane organization GO:0061024 245 0.171
positive regulation of lymphocyte activation GO:0051251 140 0.170
tolerance induction to self antigen GO:0002513 4 0.170
t cell differentiation in thymus GO:0033077 77 0.169
calcium ion homeostasis GO:0055074 127 0.167
mast cell activation GO:0045576 27 0.167
positive regulation of cellular component biogenesis GO:0044089 94 0.165
i kappab kinase nf kappab signaling GO:0007249 85 0.164
lipoxin a4 biosynthetic process GO:2001303 1 0.163
optic nerve structural organization GO:0021633 2 0.162
positive regulation of podosome assembly GO:0071803 3 0.159
regulation of protein complex assembly GO:0043254 83 0.156
actin filament bundle assembly GO:0051017 40 0.155
positive regulation of leukocyte degranulation GO:0043302 10 0.155
regulation of kinase activity GO:0043549 249 0.154
associative learning GO:0008306 61 0.154
negative regulation of homeostatic process GO:0032845 71 0.152
mapk cascade GO:0000165 281 0.152
monocyte extravasation GO:0035696 2 0.152
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.152
regulation of vesicle mediated transport GO:0060627 139 0.150
positive regulation of cell motility GO:2000147 116 0.150
b cell activation GO:0042113 161 0.150
cognition GO:0050890 149 0.149
erythrocyte differentiation GO:0030218 88 0.148
Mouse
positive regulation of kinase activity GO:0033674 155 0.148
regulation of lymphocyte apoptotic process GO:0070228 41 0.146
jnk cascade GO:0007254 72 0.146
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.145
negative regulation of growth GO:0045926 99 0.145
peptidyl amino acid modification GO:0018193 336 0.143
positive regulation of cell death GO:0010942 224 0.142
cellular amino acid metabolic process GO:0006520 103 0.142
anatomical structure homeostasis GO:0060249 145 0.142
regulation of stress activated mapk cascade GO:0032872 69 0.142
eosinophil activation involved in immune response GO:0002278 1 0.141
positive regulation of mapk cascade GO:0043410 170 0.141
wound healing GO:0042060 157 0.140
cell substrate adhesion GO:0031589 130 0.140
t cell receptor signaling pathway GO:0050852 46 0.140
sequestering of metal ion GO:0051238 19 0.139
synapse organization GO:0050808 125 0.138
coagulation GO:0050817 78 0.138
regulation of endocytosis GO:0030100 69 0.137
regulation of protein kinase activity GO:0045859 232 0.135
hemostasis GO:0007599 78 0.134
response to lipopolysaccharide GO:0032496 128 0.132
regulation of actin cytoskeleton organization GO:0032956 84 0.130
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.128
lymphocyte homeostasis GO:0002260 64 0.128
actin cytoskeleton organization GO:0030036 220 0.127
cell type specific apoptotic process GO:0097285 268 0.127
positive regulation of t cell costimulation GO:2000525 2 0.127
interferon beta biosynthetic process GO:0045350 4 0.126
gliogenesis GO:0042063 141 0.125
divalent inorganic cation transport GO:0072511 178 0.125
regulation of asymmetric cell division GO:0009786 4 0.125
t cell extravasation GO:0072683 4 0.124
response to transforming growth factor beta GO:0071559 88 0.123
developmental maturation GO:0021700 193 0.123
learning or memory GO:0007611 148 0.123
mast cell activation involved in immune response GO:0002279 20 0.122
negative regulation of nervous system development GO:0051961 156 0.122
positive regulation of leukocyte differentiation GO:1902107 86 0.121
cytokine biosynthetic process GO:0042089 68 0.121
germ cell development GO:0007281 185 0.120
positive regulation of apoptotic process GO:0043065 217 0.119
cytokine mediated signaling pathway GO:0019221 115 0.119
positive regulation of cytokine secretion GO:0050715 41 0.119
antigen processing and presentation GO:0019882 47 0.119
regulation of inflammatory response GO:0050727 147 0.119
angiogenesis GO:0001525 201 0.118
Mouse
sensory perception GO:0007600 245 0.117
regulation of ras protein signal transduction GO:0046578 114 0.117
b cell receptor signaling pathway GO:0050853 20 0.117
leukocyte activation involved in immune response GO:0002366 126 0.116
cytokine metabolic process GO:0042107 71 0.115
lymphocyte mediated immunity GO:0002449 139 0.115
kidney development GO:0001822 213 0.114
single organism cell adhesion GO:0098602 156 0.114
regulation of cellular ketone metabolic process GO:0010565 66 0.114
rho protein signal transduction GO:0007266 32 0.113
regulation of leukocyte apoptotic process GO:2000106 56 0.113
small molecule biosynthetic process GO:0044283 132 0.112
cellular response to lipid GO:0071396 145 0.112
regulation of podosome assembly GO:0071801 3 0.111
organelle localization GO:0051640 179 0.110
regulation of monocyte extravasation GO:2000437 2 0.109
positive regulation of transferase activity GO:0051347 167 0.109
positive regulation of cellular amine metabolic process GO:0033240 5 0.109
stress activated mapk cascade GO:0051403 80 0.108
protein secretion GO:0009306 111 0.108
cellular ketone metabolic process GO:0042180 84 0.108
regulation of cytokine secretion GO:0050707 61 0.108
defense response to bacterium GO:0042742 119 0.106
regulation of acute inflammatory response to antigenic stimulus GO:0002864 10 0.105
regulation of mast cell activation involved in immune response GO:0033006 17 0.105
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.105
positive regulation of immunological synapse formation GO:2000522 1 0.104
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.103
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.103
negative regulation of intracellular signal transduction GO:1902532 167 0.103
regulation of myeloid cell differentiation GO:0045637 96 0.102
Zebrafish
regulation of binding GO:0051098 111 0.102
humoral immune response GO:0006959 57 0.101
regulation of t cell costimulation GO:2000523 2 0.101
tissue homeostasis GO:0001894 115 0.101
hematopoietic stem cell migration GO:0035701 1 0.099
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 14 0.098
regulation of cell projection organization GO:0031344 206 0.098
regulation of acute inflammatory response GO:0002673 27 0.098
response to growth factor GO:0070848 198 0.098
thymic t cell selection GO:0045061 22 0.097
regulation of phospholipase c activity GO:1900274 3 0.097
response to peptide hormone GO:0043434 127 0.097
cell activation involved in immune response GO:0002263 126 0.097
platelet aggregation GO:0070527 20 0.096
positive regulation of interferon alpha production GO:0032727 4 0.096
regulation of canonical wnt signaling pathway GO:0060828 82 0.095
negative regulation of molecular function GO:0044092 258 0.095
regulation of leukocyte degranulation GO:0043300 20 0.095
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.094
muscle tissue development GO:0060537 308 0.094
establishment or maintenance of cell polarity GO:0007163 86 0.093
regulation of t cell receptor signaling pathway GO:0050856 21 0.093
positive regulation of jnk cascade GO:0046330 46 0.093
multicellular organismal signaling GO:0035637 91 0.093
response to testosterone GO:0033574 3 0.093
response to interferon gamma GO:0034341 34 0.092
regulation of t cell differentiation GO:0045580 83 0.092
establishment of organelle localization GO:0051656 122 0.091
regulation of body fluid levels GO:0050878 162 0.091
cell growth GO:0016049 130 0.091
positive regulation of immune effector process GO:0002699 107 0.091
negative regulation of b cell activation GO:0050869 27 0.091
leukocyte apoptotic process GO:0071887 71 0.090
oligodendrocyte differentiation GO:0048709 53 0.089
regulation of interleukin 8 production GO:0032677 3 0.089
gland development GO:0048732 330 0.088
regulation of hormone levels GO:0010817 211 0.088
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.088
negative regulation of protein metabolic process GO:0051248 282 0.088
regulation of cellular amine metabolic process GO:0033238 20 0.087
regulation of calcium ion transport into cytosol GO:0010522 31 0.087
learning GO:0007612 98 0.087
sphingosine 1 phosphate signaling pathway GO:0003376 3 0.087
negative regulation of cell development GO:0010721 169 0.086
cellular response to biotic stimulus GO:0071216 92 0.086
alpha beta t cell differentiation GO:0046632 69 0.086
innate immune response activating signal transduction GO:0002758 50 0.086
circulatory system process GO:0003013 197 0.086
positive regulation of map kinase activity GO:0043406 84 0.086
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.086
regulation of ion transport GO:0043269 215 0.085
regulation of t cell extravasation GO:2000407 3 0.085
cellular lipid metabolic process GO:0044255 323 0.085
developmental cell growth GO:0048588 84 0.084
response to acid chemical GO:0001101 111 0.083
macromolecule catabolic process GO:0009057 281 0.083
cell chemotaxis GO:0060326 81 0.083
regulation of protein secretion GO:0050708 82 0.082
sensory organ morphogenesis GO:0090596 242 0.082
positive regulation of protein phosphorylation GO:0001934 242 0.082
positive regulation of leukocyte apoptotic process GO:2000108 21 0.081
interleukin 1 beta production GO:0032611 30 0.081
negative regulation of response to wounding GO:1903035 77 0.081
negative regulation of leukocyte proliferation GO:0070664 46 0.081
regulation of interferon gamma production GO:0032649 57 0.081
substrate adhesion dependent cell spreading GO:0034446 30 0.081
regulation of actin filament based process GO:0032970 99 0.080
neuron migration GO:0001764 122 0.080
regulation of cytokine biosynthetic process GO:0042035 59 0.080
leukocyte mediated immunity GO:0002443 174 0.080
ensheathment of neurons GO:0007272 76 0.079
myeloid cell activation involved in immune response GO:0002275 34 0.079
regulation of hemostasis GO:1900046 28 0.078
cell fate commitment GO:0045165 210 0.078
regulation of neuron differentiation GO:0045664 281 0.077
regulation of wound healing GO:0061041 40 0.077
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.077
mast cell proliferation GO:0070662 4 0.077
lymphocyte migration GO:0072676 26 0.076
regulation of transferase activity GO:0051338 263 0.076
regulation of cytoskeleton organization GO:0051493 122 0.076
homeostasis of number of cells GO:0048872 210 0.076
Mouse
cellularization GO:0007349 1 0.076
establishment of endothelial blood brain barrier GO:0014045 3 0.075
cellular response to molecule of bacterial origin GO:0071219 83 0.075
positive regulation of neuron differentiation GO:0045666 141 0.075
organelle assembly GO:0070925 177 0.075
organic acid biosynthetic process GO:0016053 86 0.075
t helper 17 cell chemotaxis GO:0035705 1 0.074
neural precursor cell proliferation GO:0061351 121 0.074
regulation of t cell proliferation GO:0042129 92 0.074
divalent metal ion transport GO:0070838 172 0.074
toll like receptor signaling pathway GO:0002224 38 0.074
positive regulation of protein transport GO:0051222 93 0.074
tumor necrosis factor biosynthetic process GO:0042533 10 0.073
telencephalon development GO:0021537 186 0.073
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.073
protein methylation GO:0006479 81 0.073
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.072
regulation of cellular amino acid metabolic process GO:0006521 5 0.072
positive regulation of lymphocyte differentiation GO:0045621 61 0.071
microtubule based process GO:0007017 236 0.071
positive regulation of protein modification process GO:0031401 299 0.071
positive regulation of cardioblast differentiation GO:0051891 3 0.070
motor neuron axon guidance GO:0008045 26 0.070
cellular response to growth factor stimulus GO:0071363 197 0.069
positive regulation of protein kinase activity GO:0045860 144 0.069
negative regulation of t cell proliferation GO:0042130 38 0.069
microtubule cytoskeleton organization GO:0000226 157 0.069
response to extracellular stimulus GO:0009991 127 0.069
immune complex clearance GO:0002434 2 0.069
positive regulation of regulated secretory pathway GO:1903307 10 0.069
small gtpase mediated signal transduction GO:0007264 97 0.067
epidermis development GO:0008544 187 0.067
cardiac muscle tissue development GO:0048738 130 0.067
phagocytosis GO:0006909 66 0.067
ameboidal type cell migration GO:0001667 128 0.067
leukocyte degranulation GO:0043299 27 0.067
regulation of coagulation GO:0050818 31 0.066
regulation of mast cell degranulation GO:0043304 16 0.066
leukocyte homeostasis GO:0001776 79 0.066
immune complex clearance by monocytes and macrophages GO:0002436 2 0.066
positive regulation of cell adhesion GO:0045785 80 0.066
wnt signaling pathway GO:0016055 188 0.066
regulation of interleukin 1 production GO:0032652 26 0.066
endomembrane system organization GO:0010256 147 0.066
negative regulation of kinase activity GO:0033673 81 0.066
intracellular receptor signaling pathway GO:0030522 74 0.066
osteoclast differentiation GO:0030316 62 0.065
microglia differentiation GO:0014004 2 0.065
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.065
negative regulation of t cell activation GO:0050868 65 0.065
carbohydrate homeostasis GO:0033500 128 0.064
mitotic cell cycle process GO:1903047 159 0.064
acute inflammatory response GO:0002526 41 0.064
tumor necrosis factor production GO:0032640 50 0.064
axon ensheathment GO:0008366 76 0.064
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.063
regulation of b cell activation GO:0050864 81 0.063
positive regulation of defense response GO:0031349 124 0.063
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.063
negative regulation of leukocyte differentiation GO:1902106 51 0.062
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.062
regulation of lipid metabolic process GO:0019216 118 0.062
mast cell mediated immunity GO:0002448 20 0.061
regulation of intracellular transport GO:0032386 159 0.061
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.061
immunoglobulin mediated immune response GO:0016064 69 0.061
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.061
positive regulation of wnt signaling pathway GO:0030177 45 0.061
regulation of rho protein signal transduction GO:0035023 71 0.060
negative regulation of cellular component organization GO:0051129 194 0.060
transmission of nerve impulse GO:0019226 76 0.060
positive regulation of neuron projection development GO:0010976 79 0.060
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.060
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.060
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.060
renal system development GO:0072001 225 0.060
synaptic transmission GO:0007268 329 0.059
myeloid leukocyte mediated immunity GO:0002444 42 0.059
protein kinase b signaling GO:0043491 74 0.059
glycoprotein metabolic process GO:0009100 116 0.059
regulation of cell cycle process GO:0010564 160 0.058
ossification GO:0001503 216 0.058
oogenesis GO:0048477 56 0.058
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.058
hormone secretion GO:0046879 128 0.057
regulation of adaptive immune response GO:0002819 90 0.057
carbohydrate transport GO:0008643 62 0.057
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.057
neuronal action potential GO:0019228 54 0.057
epithelial tube morphogenesis GO:0060562 303 0.056
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.056
cell recognition GO:0008037 83 0.056
blood coagulation GO:0007596 76 0.056
neurohypophysis development GO:0021985 2 0.055
negative regulation of inflammatory response GO:0050728 61 0.055
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.055
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.055
positive regulation of exocytosis GO:0045921 20 0.055
immune response inhibiting signal transduction GO:0002765 4 0.055
muscle tissue morphogenesis GO:0060415 53 0.055
regulation of platelet activation GO:0010543 17 0.055
positive regulation of protein complex assembly GO:0031334 45 0.054
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.054
inner ear morphogenesis GO:0042472 101 0.054
positive regulation of phospholipase c activity GO:0010863 2 0.054
eosinophil mediated immunity GO:0002447 1 0.054
negative regulation of phosphate metabolic process GO:0045936 184 0.053
regulated secretory pathway GO:0045055 32 0.053
negative regulation of multi organism process GO:0043901 68 0.053
phospholipid metabolic process GO:0006644 87 0.053
response to ethanol GO:0045471 18 0.053
canonical wnt signaling pathway GO:0060070 130 0.052
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.052
cellular amine metabolic process GO:0044106 44 0.052
mature dendritic cell differentiation GO:0097029 3 0.052
positive regulation of acute inflammatory response GO:0002675 16 0.052
positive regulation of interferon gamma production GO:0032729 39 0.051
organelle fission GO:0048285 170 0.051
regulation of exocytosis GO:0017157 61 0.051
granulocyte chemotaxis GO:0071621 39 0.051
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.051
cell junction organization GO:0034330 77 0.051
positive regulation of antigen receptor mediated signaling pathway GO:0050857 9 0.051
extracellular structure organization GO:0043062 148 0.051
regulation of ossification GO:0030278 112 0.051
skin development GO:0043588 220 0.051
positive regulation of t cell extravasation GO:2000409 2 0.051
regulation of homotypic cell cell adhesion GO:0034110 13 0.051
regulation of actin polymerization or depolymerization GO:0008064 45 0.051
negative regulation of cytokine production GO:0001818 84 0.050
digestive tract development GO:0048565 190 0.050
metanephric loop of henle development GO:0072236 4 0.050
regulation of protein catabolic process GO:0042176 108 0.050
telencephalon cell migration GO:0022029 55 0.050
negative regulation of phosphorylation GO:0042326 166 0.049
regulation of vasculature development GO:1901342 88 0.049
regulation of erythrocyte differentiation GO:0045646 23 0.049
myeloid leukocyte migration GO:0097529 57 0.049
interleukin 4 production GO:0032633 24 0.049
positive regulation of stress activated mapk cascade GO:0032874 48 0.049
oxidation reduction process GO:0055114 342 0.049
positive regulation of organelle organization GO:0010638 128 0.048
cellular extravasation GO:0045123 17 0.048
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.048
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.047
cellular response to extracellular stimulus GO:0031668 81 0.047
protein catabolic process GO:0030163 221 0.046
insulin secretion GO:0030073 89 0.046
regulation of cellular response to growth factor stimulus GO:0090287 82 0.046
digestive tract morphogenesis GO:0048546 147 0.046
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.045
negative regulation of transferase activity GO:0051348 85 0.045
microglia development GO:0014005 2 0.045
release of sequestered calcium ion into cytosol GO:0051209 42 0.045
t cell selection GO:0045058 34 0.045
glial cell development GO:0021782 54 0.045
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.044
negative regulation of mapk cascade GO:0043409 65 0.044
formation of primary germ layer GO:0001704 77 0.044
cell maturation GO:0048469 127 0.044
negative regulation of map kinase activity GO:0043407 34 0.044
nitrogen compound transport GO:0071705 271 0.044
positive regulation of lymphocyte proliferation GO:0050671 70 0.044
regulation of bone resorption GO:0045124 24 0.043
regulation of dendritic cell apoptotic process GO:2000668 3 0.043
regulation of blood pressure GO:0008217 93 0.043
negative regulation of b cell proliferation GO:0030889 13 0.043
regulation of jnk cascade GO:0046328 62 0.043
cardiac muscle tissue growth involved in heart morphogenesis GO:0003245 1 0.043
positive regulation of interleukin 8 secretion GO:2000484 1 0.043
positive regulation of hydrolase activity GO:0051345 148 0.042
regulation of calcium mediated signaling GO:0050848 19 0.042
positive regulation of leukocyte proliferation GO:0070665 73 0.042
regulation of synapse assembly GO:0051963 29 0.042
protein autophosphorylation GO:0046777 61 0.041

Spib disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 0.260
immune system disease DOID:2914 0 0.260
disease of anatomical entity DOID:7 0 0.260
blood protein disease DOID:620 0 0.095
hematopoietic system disease DOID:74 0 0.095
musculoskeletal system disease DOID:17 0 0.042