Mus musculus

457 known processes

Sykb

spleen tyrosine kinase

(Aliases: Syk)

Sykb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune response activating signal transduction GO:0002757 116 0.998
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.978
innate immune response activating signal transduction GO:0002758 50 0.968
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.965
immune response regulating signaling pathway GO:0002764 125 0.956
b cell activation GO:0042113 161 0.955
immune effector process GO:0002252 321 0.933
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.926
leukocyte proliferation GO:0070661 172 0.897
amine metabolic process GO:0009308 45 0.892
defense response to bacterium GO:0042742 119 0.887
activation of innate immune response GO:0002218 56 0.845
interferon beta biosynthetic process GO:0045350 4 0.782
toll like receptor signaling pathway GO:0002224 38 0.762
lymphocyte homeostasis GO:0002260 64 0.745
lymphocyte differentiation GO:0030098 242 0.743
regulation of kinase activity GO:0043549 249 0.742
cellular response to biotic stimulus GO:0071216 92 0.739
cellular response to lipopolysaccharide GO:0071222 77 0.737
cellular lipid metabolic process GO:0044255 323 0.727
leukocyte mediated immunity GO:0002443 174 0.700
cellular response to lipid GO:0071396 145 0.676
regulation of leukocyte differentiation GO:1902105 159 0.656
leukocyte differentiation GO:0002521 342 0.635
peptidyl amino acid modification GO:0018193 336 0.631
regulation of leukocyte proliferation GO:0070663 121 0.631
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.626
myeloid cell differentiation GO:0030099 233 0.615
positive regulation of lymphocyte proliferation GO:0050671 70 0.602
regulation of cell adhesion GO:0030155 154 0.597
reactive oxygen species metabolic process GO:0072593 84 0.595
positive regulation of leukocyte proliferation GO:0070665 73 0.551
positive regulation of b cell activation GO:0050871 49 0.547
activation of immune response GO:0002253 138 0.530
myeloid dendritic cell differentiation GO:0043011 16 0.495
pattern recognition receptor signaling pathway GO:0002221 47 0.492
positive regulation of protein kinase activity GO:0045860 144 0.490
positive regulation of protein modification process GO:0031401 299 0.463
positive regulation of kinase activity GO:0033674 155 0.456
b cell receptor signaling pathway GO:0050853 20 0.453
regulation of b cell proliferation GO:0030888 39 0.451
positive regulation of interleukin 12 production GO:0032735 21 0.430
defense response to other organism GO:0098542 197 0.426
cytokine production GO:0001816 319 0.425
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.425
muscle cell differentiation GO:0042692 261 0.421
positive regulation of cell activation GO:0050867 158 0.410
b cell proliferation GO:0042100 53 0.410
cellular ketone metabolic process GO:0042180 84 0.401
positive regulation of innate immune response GO:0045089 80 0.381
interferon gamma production GO:0032609 67 0.377
defense response to gram positive bacterium GO:0050830 50 0.369
regulation of lymphocyte activation GO:0051249 240 0.362
b cell differentiation GO:0030183 78 0.352
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.348
dna metabolic process GO:0006259 303 0.344
activation of mapk activity GO:0000187 59 0.343
microtubule based process GO:0007017 236 0.343
cellular response to molecule of bacterial origin GO:0071219 83 0.330
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.328
adaptive immune response GO:0002250 155 0.326
immunoglobulin mediated immune response GO:0016064 69 0.325
cell fate commitment GO:0045165 210 0.324
positive regulation of phospholipase c activity GO:0010863 2 0.316
leukocyte activation involved in immune response GO:0002366 126 0.310
regulation of cellular amino acid metabolic process GO:0006521 5 0.309
regulation of cytokine biosynthetic process GO:0042035 59 0.306
regulation of mapk cascade GO:0043408 248 0.303
natural killer cell activation GO:0030101 44 0.286
negative regulation of cellular component organization GO:0051129 194 0.280
regulation of blood coagulation GO:0030193 28 0.277
antigen receptor mediated signaling pathway GO:0050851 64 0.272
i kappab kinase nf kappab signaling GO:0007249 85 0.261
regulation of endocytosis GO:0030100 69 0.259
regulation of cell activation GO:0050865 289 0.259
bone remodeling GO:0046849 53 0.258
regulation of protein serine threonine kinase activity GO:0071900 157 0.254
detection of stimulus GO:0051606 84 0.252
positive regulation of map kinase activity GO:0043406 84 0.246
positive regulation of cytokine production GO:0001819 174 0.246
positive regulation of b cell proliferation GO:0030890 24 0.243
myeloid cell homeostasis GO:0002262 114 0.241
regulation of innate immune response GO:0045088 91 0.239
innate immune response GO:0045087 157 0.239
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.237
dendrite development GO:0016358 115 0.237
regulation of stress activated mapk cascade GO:0032872 69 0.231
negative regulation of cell proliferation GO:0008285 296 0.230
negative regulation of antigen receptor mediated signaling pathway GO:0050858 16 0.229
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.228
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.227
t cell differentiation GO:0030217 174 0.227
regulation of protein kinase activity GO:0045859 232 0.227
reactive oxygen species biosynthetic process GO:1903409 8 0.227
production of molecular mediator of immune response GO:0002440 103 0.225
positive regulation of protein phosphorylation GO:0001934 242 0.223
membrane organization GO:0061024 245 0.221
regulation of hemostasis GO:1900046 28 0.219
negative regulation of cellular protein metabolic process GO:0032269 247 0.216
regulation of cell migration GO:0030334 219 0.212
Zebrafish
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.210
erk1 and erk2 cascade GO:0070371 77 0.207
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.204
endodermal cell fate specification GO:0001714 4 0.203
coagulation GO:0050817 78 0.201
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.200
platelet morphogenesis GO:0036344 13 0.198
negative regulation of protein metabolic process GO:0051248 282 0.192
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.188
regulation of phospholipase c activity GO:1900274 3 0.188
stress activated mapk cascade GO:0051403 80 0.187
b cell homeostasis GO:0001782 34 0.181
defense response to virus GO:0051607 68 0.180
response to lipopolysaccharide GO:0032496 128 0.180
regulation of lymphocyte proliferation GO:0050670 117 0.178
protein autophosphorylation GO:0046777 61 0.177
response to molecule of bacterial origin GO:0002237 143 0.177
lateral inhibition GO:0046331 1 0.177
positive regulation of lymphocyte activation GO:0051251 140 0.175
positive regulation of leukocyte apoptotic process GO:2000108 21 0.174
regulation of neuron projection development GO:0010975 169 0.174
t cell activation GO:0042110 289 0.174
intracellular receptor signaling pathway GO:0030522 74 0.169
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.168
epithelial tube morphogenesis GO:0060562 303 0.167
tumor necrosis factor production GO:0032640 50 0.166
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.166
glycosyl compound metabolic process GO:1901657 246 0.166
positive regulation of cell development GO:0010720 237 0.165
regulation of t cell activation GO:0050863 170 0.165
phospholipid metabolic process GO:0006644 87 0.162
skin development GO:0043588 220 0.162
regulation of cellular response to stress GO:0080135 159 0.162
oogenesis GO:0048477 56 0.158
Fly
germ cell development GO:0007281 185 0.156
Fly
negative regulation of synapse assembly GO:0051964 3 0.155
positive regulation of immune effector process GO:0002699 107 0.153
platelet degranulation GO:0002576 6 0.151
positive regulation of hemostasis GO:1900048 10 0.148
positive regulation of leukocyte mediated immunity GO:0002705 70 0.145
regulation of b cell activation GO:0050864 81 0.145
osteoclast differentiation GO:0030316 62 0.144
establishment or maintenance of cell polarity GO:0007163 86 0.143
Fly
reactive nitrogen species metabolic process GO:2001057 0 0.143
regulation of reactive oxygen species metabolic process GO:2000377 40 0.141
regulation of actin polymerization or depolymerization GO:0008064 45 0.141
regulation of calcium ion transport GO:0051924 69 0.140
negative regulation of endothelial cell migration GO:0010596 4 0.139
response to inorganic substance GO:0010035 96 0.138
regulation of platelet activation GO:0010543 17 0.138
negative regulation of kinase activity GO:0033673 81 0.137
megakaryocyte differentiation GO:0030219 26 0.135
negative regulation of immune system process GO:0002683 209 0.134
protein ubiquitination GO:0016567 171 0.134
response to peptide GO:1901652 136 0.132
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.132
positive regulation of transferase activity GO:0051347 167 0.129
lipid localization GO:0010876 126 0.129
myeloid dendritic cell activation GO:0001773 25 0.129
response to retinoic acid GO:0032526 56 0.128
oocyte anterior posterior axis specification GO:0007314 2 0.124
digestive tract development GO:0048565 190 0.123
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.121
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.119
filtration diaphragm assembly GO:0036058 1 0.119
negative regulation of molecular function GO:0044092 258 0.119
protein secretion GO:0009306 111 0.118
regulation of defense response GO:0031347 233 0.116
regulation of erythrocyte differentiation GO:0045646 23 0.115
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.114
renal system development GO:0072001 225 0.114
regulation of podosome assembly GO:0071801 3 0.114
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.113
regulation of interferon beta biosynthetic process GO:0045357 4 0.113
microtubule cytoskeleton organization GO:0000226 157 0.112
negative regulation of map kinase activity GO:0043407 34 0.112
regulation of homeostatic process GO:0032844 182 0.110
negative regulation of phosphorus metabolic process GO:0010563 184 0.109
regulation of jnk cascade GO:0046328 62 0.107
regulation of homotypic cell cell adhesion GO:0034110 13 0.107
regulation of cellular ketone metabolic process GO:0010565 66 0.104
regulation of mast cell degranulation GO:0043304 16 0.103
response to molecule of fungal origin GO:0002238 4 0.103
t cell proliferation GO:0042098 120 0.102
regulation of organelle organization GO:0033043 289 0.101
platelet activation GO:0030168 40 0.100
inflammatory response GO:0006954 244 0.100
striated muscle tissue development GO:0014706 293 0.100
intracellular mrna localization GO:0008298 4 0.100
b cell mediated immunity GO:0019724 71 0.099
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.099
positive regulation of neuron differentiation GO:0045666 141 0.099
positive regulation of cellular amine metabolic process GO:0033240 5 0.098
b cell activation involved in immune response GO:0002312 50 0.098
gland development GO:0048732 330 0.097
ras protein signal transduction GO:0007265 77 0.097
interspecies interaction between organisms GO:0044419 83 0.097
negative regulation of cell migration GO:0030336 59 0.097
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.097
Human
organelle assembly GO:0070925 177 0.096
regulation of transferase activity GO:0051338 263 0.096
response to organonitrogen compound GO:0010243 246 0.096
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.096
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 6 0.094
response to transforming growth factor beta GO:0071559 88 0.094
developmental maturation GO:0021700 193 0.093
positive regulation of interferon beta production GO:0032728 8 0.093
regulation of actin cytoskeleton organization GO:0032956 84 0.093
response to endoplasmic reticulum stress GO:0034976 53 0.092
actin cytoskeleton reorganization GO:0031532 21 0.092
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.091
pole plasm assembly GO:0007315 2 0.091
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.090
mapk cascade GO:0000165 281 0.089
cell activation involved in immune response GO:0002263 126 0.089
antimicrobial peptide biosynthetic process GO:0002777 2 0.088
morphogenesis of embryonic epithelium GO:0016331 159 0.088
Fly
negative regulation of phosphorylation GO:0042326 166 0.087
oocyte construction GO:0007308 2 0.087
blood coagulation GO:0007596 76 0.087
regulation of interleukin 6 production GO:0032675 55 0.087
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.087
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.086
negative regulation of protein modification process GO:0031400 163 0.086
regulation of map kinase activity GO:0043405 120 0.086
cellular amine metabolic process GO:0044106 44 0.085
somatic cell dna recombination GO:0016444 51 0.085
regulation of erk1 and erk2 cascade GO:0070372 71 0.083
cell maturation GO:0048469 127 0.083
type i interferon production GO:0032606 29 0.082
positive regulation of t cell activation GO:0050870 101 0.082
interferon beta production GO:0032608 16 0.082
cellular amino acid metabolic process GO:0006520 103 0.082
cation transport GO:0006812 399 0.082
platelet aggregation GO:0070527 20 0.081
alpha beta t cell differentiation GO:0046632 69 0.080
axon guidance GO:0007411 141 0.080
neutrophil differentiation GO:0030223 3 0.079
regulation of lymphocyte differentiation GO:0045619 107 0.078
sequestering of calcium ion GO:0051208 18 0.078
syncytium formation GO:0006949 43 0.078
skeletal muscle organ development GO:0060538 163 0.078
endocytosis GO:0006897 168 0.078
posttranscriptional regulation of gene expression GO:0010608 155 0.078
positive regulation of podosome assembly GO:0071803 3 0.078
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.078
b cell apoptotic process GO:0001783 19 0.077
nucleoside catabolic process GO:0009164 206 0.077
single organismal cell cell adhesion GO:0016337 131 0.077
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.077
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.076
regulation of cell cycle GO:0051726 281 0.076
actin polymerization or depolymerization GO:0008154 54 0.075
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.075
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.075
regulation of lipid transport GO:0032368 36 0.074
pyrimidine containing compound metabolic process GO:0072527 11 0.074
regulation of interferon gamma production GO:0032649 57 0.074
positive regulation of cell death GO:0010942 224 0.074
organophosphate catabolic process GO:0046434 232 0.073
regulation of coagulation GO:0050818 31 0.073
interleukin 6 production GO:0032635 58 0.072
macrophage derived foam cell differentiation GO:0010742 6 0.072
positive regulation of jnk cascade GO:0046330 46 0.072
hair cell differentiation GO:0035315 40 0.071
positive regulation of interferon alpha production GO:0032727 4 0.070
regulation of dendritic cell apoptotic process GO:2000668 3 0.070
establishment of organelle localization GO:0051656 122 0.070
lymphocyte apoptotic process GO:0070227 54 0.069
leukocyte migration GO:0050900 124 0.069
Human
regionalization GO:0003002 337 0.069
protein oligomerization GO:0051259 67 0.069
peptidyl tyrosine modification GO:0018212 145 0.069
negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 3 0.069
purine ribonucleotide catabolic process GO:0009154 208 0.069
negative regulation of cellular amine metabolic process GO:0033239 1 0.069
purine ribonucleotide metabolic process GO:0009150 290 0.069
regulation of wound healing GO:0061041 40 0.068
lipid biosynthetic process GO:0008610 179 0.068
mast cell proliferation GO:0070662 4 0.068
neural tube development GO:0021915 160 0.068
regulation of chemokine production GO:0032642 30 0.067
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.067
cell killing GO:0001906 67 0.067
actin filament organization GO:0007015 113 0.066
tissue remodeling GO:0048771 102 0.066
aromatic compound catabolic process GO:0019439 286 0.066
histone modification GO:0016570 159 0.066
maintenance of location GO:0051235 89 0.065
hypermethylation of cpg island GO:0044027 3 0.065
negative regulation of transferase activity GO:0051348 85 0.065
neural tube formation GO:0001841 108 0.065
macrophage differentiation GO:0030225 20 0.065
response to oxidative stress GO:0006979 123 0.065
cellular response to retinoic acid GO:0071300 25 0.065
extrinsic apoptotic signaling pathway GO:0097191 126 0.065
regulation of binding GO:0051098 111 0.064
antigen processing and presentation GO:0019882 47 0.064
cell cell junction organization GO:0045216 72 0.063
glycerolipid metabolic process GO:0046486 122 0.062
organic hydroxy compound metabolic process GO:1901615 203 0.062
axonogenesis GO:0007409 274 0.061
divalent inorganic cation transport GO:0072511 178 0.060
regulation of natural killer cell activation GO:0032814 22 0.060
regulation of organ morphogenesis GO:2000027 144 0.060
positive regulation of blood coagulation GO:0030194 10 0.060
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.059
chemotaxis GO:0006935 247 0.059
Human
single organism cell adhesion GO:0098602 156 0.059
negative regulation of lymphocyte proliferation GO:0050672 45 0.059
regulation of hydrolase activity GO:0051336 246 0.058
regulation of lipid kinase activity GO:0043550 14 0.058
antibacterial peptide production GO:0002778 2 0.058
regulation of establishment of protein localization GO:0070201 181 0.058
primary neural tube formation GO:0014020 95 0.058
cell recognition GO:0008037 83 0.058
placenta development GO:0001890 140 0.057
regulation of cytokine production GO:0001817 266 0.057
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.057
negative regulation of protein phosphorylation GO:0001933 126 0.057
regulation of response to wounding GO:1903034 189 0.057
positive regulation of chemokine production GO:0032722 22 0.057
extracellular matrix organization GO:0030198 147 0.056
negative regulation of mast cell proliferation GO:0070667 1 0.056
female gamete generation GO:0007292 74 0.056
Fly
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.056
regulation of removal of superoxide radicals GO:2000121 4 0.055
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.055
wound healing GO:0042060 157 0.055
cell type specific apoptotic process GO:0097285 268 0.055
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.055
positive regulation of apoptotic process GO:0043065 217 0.054
negative regulation of phosphate metabolic process GO:0045936 184 0.054
spindle localization GO:0051653 22 0.054
peptidyl lysine modification GO:0018205 77 0.054
positive regulation of antimicrobial peptide production GO:0002225 1 0.054
natural killer cell mediated immunity GO:0002228 29 0.054
gamma delta t cell differentiation GO:0042492 11 0.054
cell adhesion GO:0007155 329 0.053
regulation of retina development in camera type eye GO:1902866 3 0.053
regulation of interferon beta production GO:0032648 13 0.053
regulation of lymphocyte mediated immunity GO:0002706 84 0.053
regulation of mast cell proliferation GO:0070666 4 0.053
glial cell development GO:0021782 54 0.052
regulation of cell motility GO:2000145 236 0.052
Zebrafish
regulation of actin filament based process GO:0032970 99 0.052
macromolecule catabolic process GO:0009057 281 0.052
negative regulation of myeloid cell differentiation GO:0045638 38 0.052
chromatin organization GO:0006325 206 0.052
cell division GO:0051301 120 0.051
odontogenesis GO:0042476 78 0.051
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.050
mast cell mediated immunity GO:0002448 20 0.050
cell junction organization GO:0034330 77 0.050
cell cycle g1 s phase transition GO:0044843 57 0.050
cellular response to acid chemical GO:0071229 68 0.050
morphogenesis of a branching structure GO:0001763 203 0.049
regulation of t cell receptor signaling pathway GO:0050856 21 0.049
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.049
regulation of cellular component biogenesis GO:0044087 181 0.049
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.049
natural killer cell mediated cytotoxicity GO:0042267 29 0.049
monocarboxylic acid biosynthetic process GO:0072330 61 0.048
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.048
forebrain development GO:0030900 302 0.048
peptidyl tyrosine dephosphorylation GO:0035335 23 0.048
release of sequestered calcium ion into cytosol GO:0051209 42 0.048
intracellular protein transport GO:0006886 204 0.048
Human
negative regulation of cell activation GO:0050866 111 0.048
negative regulation of intracellular signal transduction GO:1902532 167 0.048
substrate adhesion dependent cell spreading GO:0034446 30 0.048
endodermal cell fate commitment GO:0001711 12 0.048
apoptotic signaling pathway GO:0097190 306 0.048
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.047
epidermis development GO:0008544 187 0.047
labyrinthine layer development GO:0060711 49 0.047
positive regulation of programmed cell death GO:0043068 218 0.047
activation of rac gtpase activity GO:0032863 2 0.047
sequestering of metal ion GO:0051238 19 0.047
purine ribonucleoside catabolic process GO:0046130 205 0.047
negative regulation of interleukin 13 secretion GO:2000666 1 0.046
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.046
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.046
glycosyl compound catabolic process GO:1901658 206 0.046
regulation of cd8 positive alpha beta t cell activation GO:2001185 3 0.046
positive regulation of stress activated mapk cascade GO:0032874 48 0.046
digestive system development GO:0055123 200 0.046
integrin mediated signaling pathway GO:0007229 27 0.046
regulation of cytoskeleton organization GO:0051493 122 0.046
gastrulation GO:0007369 116 0.046
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.046
cellular nitrogen compound catabolic process GO:0044270 280 0.045
regulation of protein localization GO:0032880 231 0.045
kidney development GO:0001822 213 0.045
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.044
embryonic placenta development GO:0001892 98 0.044
nucleoside triphosphate catabolic process GO:0009143 205 0.044
leukocyte mediated cytotoxicity GO:0001909 62 0.044
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.044
Fly
positive regulation of macrophage chemotaxis GO:0010759 5 0.044
negative regulation of t cell activation GO:0050868 65 0.043
regulation of cell shape GO:0008360 39 0.043
Fly
cellular response to oxidative stress GO:0034599 76 0.042
regulation of b cell apoptotic process GO:0002902 13 0.042
small gtpase mediated signal transduction GO:0007264 97 0.042
response to platelet derived growth factor GO:0036119 6 0.042
establishment of spindle localization GO:0051293 19 0.042
homotypic cell cell adhesion GO:0034109 28 0.042
regulation of protein binding GO:0043393 60 0.042
immune response inhibiting signal transduction GO:0002765 4 0.042
regulation of ion transport GO:0043269 215 0.042
substrate dependent cell migration GO:0006929 18 0.042
positive regulation of type i interferon production GO:0032481 14 0.041
lymphocyte proliferation GO:0046651 164 0.041
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.041
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.041
homeostasis of number of cells GO:0048872 210 0.041
regulation of response to biotic stimulus GO:0002831 38 0.041
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.040
cytokine mediated signaling pathway GO:0019221 115 0.040
regulation of bone resorption GO:0045124 24 0.040
positive regulation of osteoclast differentiation GO:0045672 15 0.040
ribonucleoside triphosphate metabolic process GO:0009199 220 0.040
regulation of notch signaling pathway GO:0008593 35 0.040
digestive tract morphogenesis GO:0048546 147 0.040
endoderm development GO:0007492 45 0.040
labyrinthine layer blood vessel development GO:0060716 21 0.040
regulation of ras protein signal transduction GO:0046578 114 0.039
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.039
muscle cell proliferation GO:0033002 52 0.039
cellularization GO:0007349 1 0.039
maternal determination of anterior posterior axis embryo GO:0008358 2 0.039
blood vessel morphogenesis GO:0048514 285 0.039
response to dsrna GO:0043331 30 0.039
somatic diversification of immunoglobulins GO:0016445 43 0.039
peptidyl tyrosine phosphorylation GO:0018108 143 0.039
cellular response to growth factor stimulus GO:0071363 197 0.039
extracellular structure organization GO:0043062 148 0.039
positive regulation of interferon gamma production GO:0032729 39 0.038
t cell receptor signaling pathway GO:0050852 46 0.038
Mouse
heterocycle catabolic process GO:0046700 280 0.038
negative regulation of notch signaling pathway GO:0045746 14 0.038
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.038
regulation of cell cycle process GO:0010564 160 0.038
organelle localization GO:0051640 179 0.038
stem cell differentiation GO:0048863 268 0.038
negative regulation of interleukin 6 production GO:0032715 17 0.037
bone mineralization GO:0030282 54 0.037
positive regulation of antimicrobial humoral response GO:0002760 2 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.037
small molecule biosynthetic process GO:0044283 132 0.037
erythrocyte differentiation GO:0030218 88 0.037
pharynx development GO:0060465 1 0.037
gtp catabolic process GO:0006184 143 0.037
monocarboxylic acid metabolic process GO:0032787 191 0.036
toll like receptor 4 signaling pathway GO:0034142 9 0.036
glial cell differentiation GO:0010001 131 0.036
response to reactive oxygen species GO:0000302 56 0.036
regulation of type i interferon production GO:0032479 22 0.036
positive regulation of cell migration GO:0030335 109 0.036
Zebrafish
positive regulation of leukocyte differentiation GO:1902107 86 0.036
dna recombination GO:0006310 92 0.036
muscle tissue development GO:0060537 308 0.036
purine nucleoside triphosphate catabolic process GO:0009146 203 0.036
positive regulation of interleukin 18 production GO:0032741 2 0.036
microglia differentiation GO:0014004 2 0.036
canonical wnt signaling pathway GO:0060070 130 0.036
positive regulation of hydrolase activity GO:0051345 148 0.035
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.035
positive regulation of cell cycle GO:0045787 92 0.035
lymphocyte mediated immunity GO:0002449 139 0.035
myeloid cell activation involved in immune response GO:0002275 34 0.035
cellular response to peptidoglycan GO:0071224 4 0.035
regulation of cellular component size GO:0032535 121 0.035
regulation of cellular response to oxidative stress GO:1900407 19 0.035
organic cyclic compound catabolic process GO:1901361 295 0.034
regulation of defense response to fungus GO:1900150 1 0.034
i kappab phosphorylation GO:0007252 6 0.034
mammary gland epithelium development GO:0061180 65 0.034

Sykb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone inflammation disease DOID:3342 0 0.187
bone disease DOID:0080001 0 0.187
rheumatoid arthritis DOID:7148 0 0.187
disease of anatomical entity DOID:7 0 0.187
musculoskeletal system disease DOID:17 0 0.187
connective tissue disease DOID:65 0 0.187
arthritis DOID:848 0 0.187
immune system disease DOID:2914 0 0.164
primary immunodeficiency disease DOID:612 0 0.143
b cell deficiency DOID:2115 0 0.143
blood protein disease DOID:620 0 0.068
agammaglobulinemia DOID:2583 0 0.068
common variable immunodeficiency DOID:12177 0 0.068
hematopoietic system disease DOID:74 0 0.068
disease of metabolism DOID:0014667 0 0.066
acquired metabolic disease DOID:0060158 0 0.066
carbohydrate metabolism disease DOID:0050013 0 0.044
glucose metabolism disease DOID:4194 0 0.044
cancer DOID:162 0 0.037
disease of cellular proliferation DOID:14566 0 0.037