Mus musculus

0 known processes

Tab3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

(Aliases: 4921526G09Rik,mKIAA4135,Map3k7ip3,KIAA4135)

Tab3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein catabolic process GO:0030163 221 0.664
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.569
modification dependent protein catabolic process GO:0019941 133 0.553
cellular protein catabolic process GO:0044257 155 0.482
ubiquitin dependent protein catabolic process GO:0006511 129 0.474
modification dependent macromolecule catabolic process GO:0043632 133 0.447
macromolecule catabolic process GO:0009057 281 0.424
protein ubiquitination GO:0016567 171 0.343
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.315
protein modification by small protein conjugation or removal GO:0070647 207 0.244
positive regulation of cellular catabolic process GO:0031331 148 0.224
protein modification by small protein conjugation GO:0032446 187 0.170
cellular macromolecule catabolic process GO:0044265 206 0.145
regulation of cellular catabolic process GO:0031329 242 0.116
myeloid cell differentiation GO:0030099 233 0.103
protein polyubiquitination GO:0000209 33 0.103
purine ribonucleoside catabolic process GO:0046130 205 0.101
small gtpase mediated signal transduction GO:0007264 97 0.098
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.095
meiosis i GO:0007127 60 0.091
purine nucleoside metabolic process GO:0042278 241 0.079
spermatogenesis GO:0007283 284 0.076
posttranscriptional regulation of gene expression GO:0010608 155 0.074
wnt signaling pathway GO:0016055 188 0.073
organelle localization GO:0051640 179 0.073
regulation of cellular amine metabolic process GO:0033238 20 0.065
purine nucleoside triphosphate catabolic process GO:0009146 203 0.065
covalent chromatin modification GO:0016569 163 0.063
histone modification GO:0016570 159 0.063
proteasomal protein catabolic process GO:0010498 98 0.063
nucleobase containing small molecule metabolic process GO:0055086 352 0.062
chromatin organization GO:0006325 206 0.058
male gamete generation GO:0048232 285 0.054
glycosyl compound metabolic process GO:1901657 246 0.053
nucleoside metabolic process GO:0009116 246 0.052
negative regulation of cellular component organization GO:0051129 194 0.049
i kappab kinase nf kappab signaling GO:0007249 85 0.047
cellular homeostasis GO:0019725 240 0.045
purine ribonucleotide metabolic process GO:0009150 290 0.044
purine ribonucleoside metabolic process GO:0046128 241 0.044
negative regulation of cellular protein metabolic process GO:0032269 247 0.043
rho protein signal transduction GO:0007266 32 0.043
positive regulation of macroautophagy GO:0016239 3 0.042
t cell activation GO:0042110 289 0.042
response to growth factor GO:0070848 198 0.041
establishment of organelle localization GO:0051656 122 0.041
ribose phosphate metabolic process GO:0019693 291 0.041
heterocycle catabolic process GO:0046700 280 0.039
ribonucleoside triphosphate catabolic process GO:0009203 199 0.038
regulation of chromatin silencing GO:0031935 2 0.038
apoptotic signaling pathway GO:0097190 306 0.038
carbohydrate derivative catabolic process GO:1901136 231 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.036
ribonucleoside triphosphate metabolic process GO:0009199 220 0.036
histone h3 k9 dimethylation GO:0036123 4 0.036
organonitrogen compound catabolic process GO:1901565 264 0.035
purine containing compound catabolic process GO:0072523 213 0.035
ribonucleotide catabolic process GO:0009261 208 0.035
cellular response to nutrient levels GO:0031669 64 0.035
nucleoside phosphate catabolic process GO:1901292 222 0.035
embryonic epithelial tube formation GO:0001838 130 0.033
positive regulation of organelle organization GO:0010638 128 0.033
regulation of hydrolase activity GO:0051336 246 0.033
cellular response to external stimulus GO:0071496 88 0.033
purine nucleotide metabolic process GO:0006163 302 0.032
respiratory system development GO:0060541 190 0.032
organophosphate catabolic process GO:0046434 232 0.032
glycosyl compound catabolic process GO:1901658 206 0.032
regulation of cellular component biogenesis GO:0044087 181 0.031
positive regulation of protein kinase activity GO:0045860 144 0.031
compound eye development GO:0048749 1 0.031
metal ion homeostasis GO:0055065 189 0.031
nucleoside triphosphate catabolic process GO:0009143 205 0.031
regulation of cellular protein catabolic process GO:1903362 61 0.031
organelle fission GO:0048285 170 0.031
gtp catabolic process GO:0006184 143 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.030
guanosine containing compound metabolic process GO:1901068 144 0.030
male meiosis i GO:0007141 16 0.029
regulation of organelle organization GO:0033043 289 0.029
cellular response to growth factor stimulus GO:0071363 197 0.029
microtubule based process GO:0007017 236 0.028
positive regulation of apoptotic signaling pathway GO:2001235 95 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
positive regulation of proteolysis GO:0045862 85 0.028
nucleotide catabolic process GO:0009166 217 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.027
spermatid development GO:0007286 108 0.027
amine metabolic process GO:0009308 45 0.027
exocytosis GO:0006887 121 0.027
germ cell development GO:0007281 185 0.027
erythrocyte differentiation GO:0030218 88 0.027
ras protein signal transduction GO:0007265 77 0.027
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.027
positive regulation of kinase activity GO:0033674 155 0.026
spermatid nucleus elongation GO:0007290 4 0.026
regulation of kinase activity GO:0043549 249 0.026
negative regulation of protein metabolic process GO:0051248 282 0.026
dna metabolic process GO:0006259 303 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
cation homeostasis GO:0055080 212 0.026
microtubule cytoskeleton organization GO:0000226 157 0.026
cellular amine metabolic process GO:0044106 44 0.026
vesicle localization GO:0051648 86 0.026
regulation of histone modification GO:0031056 56 0.026
guanosine containing compound catabolic process GO:1901069 144 0.026
aromatic compound catabolic process GO:0019439 286 0.026
regulation of transferase activity GO:0051338 263 0.026
gtp metabolic process GO:0046039 144 0.026
negative regulation of intracellular signal transduction GO:1902532 167 0.025
cytoplasmic transport GO:0016482 234 0.025
regulation of apoptotic signaling pathway GO:2001233 197 0.025
methylation GO:0032259 134 0.025
defense response to other organism GO:0098542 197 0.025
ribonucleoside catabolic process GO:0042454 206 0.025
negative regulation of molecular function GO:0044092 258 0.025
regulation of wnt signaling pathway GO:0030111 123 0.024
regulation of protein catabolic process GO:0042176 108 0.024
development of primary sexual characteristics GO:0045137 143 0.024
cell adhesion GO:0007155 329 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
myeloid cell homeostasis GO:0002262 114 0.024
cellular chemical homeostasis GO:0055082 215 0.024
regulation of ras gtpase activity GO:0032318 88 0.023
regulation of nucleotide metabolic process GO:0006140 169 0.023
actin cytoskeleton organization GO:0030036 220 0.023
cellular nitrogen compound catabolic process GO:0044270 280 0.023
cellular response to dna damage stimulus GO:0006974 207 0.023
intermediate filament based process GO:0045103 27 0.023
purine nucleotide catabolic process GO:0006195 211 0.022
immune effector process GO:0002252 321 0.022
regulation of defense response GO:0031347 233 0.022
axonogenesis GO:0007409 274 0.022
osteoclast differentiation GO:0030316 62 0.022
purine containing compound metabolic process GO:0072521 311 0.022
cation transport GO:0006812 399 0.022
establishment of protein localization to organelle GO:0072594 118 0.022
histone h2a ubiquitination GO:0033522 3 0.021
nucleotide metabolic process GO:0009117 332 0.021
protein polymerization GO:0051258 57 0.021
synaptic transmission GO:0007268 329 0.021
regulation of cellular response to growth factor stimulus GO:0090287 82 0.021
gonad development GO:0008406 141 0.021
regulation of chromosome organization GO:0033044 83 0.021
regulation of response to wounding GO:1903034 189 0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.021
ribonucleoside metabolic process GO:0009119 245 0.020
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.020
negative regulation of hydrolase activity GO:0051346 71 0.020
positive regulation of hydrolase activity GO:0051345 148 0.020
mitotic cell cycle process GO:1903047 159 0.020
localization within membrane GO:0051668 4 0.020
regulation of peptidase activity GO:0052547 96 0.020
positive regulation of apoptotic process GO:0043065 217 0.020
regulation of cell projection organization GO:0031344 206 0.020
nuclear division GO:0000280 158 0.020
meiotic cell cycle GO:0051321 122 0.020
regionalization GO:0003002 337 0.019
peptidyl amino acid modification GO:0018193 336 0.019
phagocytosis GO:0006909 66 0.019
chromatin modification GO:0016568 187 0.019
mitotic cell cycle GO:0000278 195 0.019
protein maturation GO:0051604 176 0.019
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.019
negative regulation of immune system process GO:0002683 209 0.019
protein autophosphorylation GO:0046777 61 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
macromolecular complex disassembly GO:0032984 43 0.019
endomembrane system organization GO:0010256 147 0.018
gland development GO:0048732 330 0.018
membrane organization GO:0061024 245 0.018
macroautophagy GO:0016236 21 0.018
response to extracellular stimulus GO:0009991 127 0.018
establishment or maintenance of cell polarity GO:0007163 86 0.018
digestive system development GO:0055123 200 0.018
ion transmembrane transport GO:0034220 361 0.018
regulation of cellular component size GO:0032535 121 0.018
respiratory tube development GO:0030323 167 0.018
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
regulation of cell migration GO:0030334 219 0.018
muscle cell fate specification GO:0042694 1 0.018
regulation of proteolysis GO:0030162 164 0.017
negative regulation of protein phosphorylation GO:0001933 126 0.017
copii coated vesicle budding GO:0090114 2 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
single organism cell adhesion GO:0098602 156 0.017
lipid localization GO:0010876 126 0.017
regulation of cellular response to stress GO:0080135 159 0.017
canonical wnt signaling pathway GO:0060070 130 0.017
rna 3 end processing GO:0031123 20 0.017
macromolecule methylation GO:0043414 120 0.017
fat cell differentiation GO:0045444 160 0.017
negative regulation of protein modification process GO:0031400 163 0.017
cell matrix adhesion GO:0007160 68 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
interleukin 6 production GO:0032635 58 0.017
cellular amino acid metabolic process GO:0006520 103 0.017
regulation of protein kinase activity GO:0045859 232 0.017
negative regulation of apoptotic signaling pathway GO:2001234 104 0.017
positive regulation of protein modification process GO:0031401 299 0.017
developmental growth involved in morphogenesis GO:0060560 138 0.016
regulation of autophagy GO:0010506 30 0.016
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.016
regulation of response to dna damage stimulus GO:2001020 34 0.016
placenta development GO:0001890 140 0.016
response to nutrient levels GO:0031667 109 0.016
regulation of chromatin modification GO:1903308 57 0.016
protein deubiquitination GO:0016579 19 0.016
cellular response to lipid GO:0071396 145 0.016
regulation of innate immune response GO:0045088 91 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
transition metal ion homeostasis GO:0055076 54 0.016
response to organic cyclic compound GO:0014070 198 0.016
asymmetric stem cell division GO:0098722 3 0.016
vesicle coating GO:0006901 2 0.016
regulation of body fluid levels GO:0050878 162 0.016
cellular response to extracellular stimulus GO:0031668 81 0.016
cell type specific apoptotic process GO:0097285 268 0.015
activation of innate immune response GO:0002218 56 0.015
bmp signaling pathway GO:0030509 93 0.015
positive regulation of transferase activity GO:0051347 167 0.015
positive regulation of homeostatic process GO:0032846 64 0.015
small molecule biosynthetic process GO:0044283 132 0.015
gpi anchor biosynthetic process GO:0006506 6 0.015
transmembrane transport GO:0055085 412 0.015
regulation of anatomical structure size GO:0090066 178 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
regulation of ion transmembrane transport GO:0034765 119 0.015
regulation of protein complex assembly GO:0043254 83 0.015
protein modification by small protein removal GO:0070646 21 0.015
response to lipopolysaccharide GO:0032496 128 0.015
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.015
regulation of lymphocyte proliferation GO:0050670 117 0.015
cellular response to biotic stimulus GO:0071216 92 0.015
protein localization to organelle GO:0033365 185 0.015
regulation of translation GO:0006417 71 0.015
cellular ion homeostasis GO:0006873 165 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.015
regulation of transmembrane transport GO:0034762 128 0.014
snrna metabolic process GO:0016073 1 0.014
protein localization to vacuole GO:0072665 4 0.014
protein targeting GO:0006605 143 0.014
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.014
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.014
meiotic cell cycle process GO:1903046 77 0.014
positive regulation of ras gtpase activity GO:0032320 65 0.014
asymmetric neuroblast division GO:0055059 1 0.014
cellular protein complex assembly GO:0043623 116 0.014
synapse organization GO:0050808 125 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
activation of nf kappab inducing kinase activity GO:0007250 4 0.014
oocyte axis specification GO:0007309 2 0.014
homeostasis of number of cells GO:0048872 210 0.014
nucleoside monophosphate catabolic process GO:0009125 59 0.014
regulation of proteasomal protein catabolic process GO:0061136 46 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
regulation of interleukin 6 production GO:0032675 55 0.013
regulation of feeding behavior GO:0060259 3 0.013
reactive oxygen species metabolic process GO:0072593 84 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
regulation of rho protein signal transduction GO:0035023 71 0.013
appendage development GO:0048736 166 0.013
regulation of t cell activation GO:0050863 170 0.013
gpi anchor metabolic process GO:0006505 7 0.013
actin filament organization GO:0007015 113 0.013
divalent inorganic cation homeostasis GO:0072507 138 0.013
nucleoside catabolic process GO:0009164 206 0.013
regulation of actin filament polymerization GO:0030833 38 0.013
cellular ketone metabolic process GO:0042180 84 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.013
protein localization to chromosome centromeric region GO:0071459 1 0.013
rab protein signal transduction GO:0032482 1 0.013
stress activated mapk cascade GO:0051403 80 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
negative regulation of growth GO:0045926 99 0.013
regulation of defense response to bacterium GO:1900424 3 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
mitochondrial transport GO:0006839 36 0.012
multicellular organism growth GO:0035264 161 0.012
regulation of endopeptidase activity GO:0052548 89 0.012
divalent inorganic cation transport GO:0072511 178 0.012
regulation of androgen receptor signaling pathway GO:0060765 3 0.012
cellular response to starvation GO:0009267 57 0.012
demethylation GO:0070988 23 0.012
histone lysine demethylation GO:0070076 13 0.012
anion transport GO:0006820 177 0.012
actin filament based movement GO:0030048 23 0.012
rna processing GO:0006396 105 0.012
fertilization GO:0009566 127 0.012
endocytosis GO:0006897 168 0.012
response to transforming growth factor beta GO:0071559 88 0.012
regulation of nucleoside metabolic process GO:0009118 130 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.012
maintenance of location GO:0051235 89 0.011
glucose homeostasis GO:0042593 128 0.011
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.011
blastocyst development GO:0001824 80 0.011
protein acylation GO:0043543 64 0.011
nitrogen compound transport GO:0071705 271 0.011
carbon catabolite regulation of transcription GO:0045990 4 0.011
golgi to endosome transport GO:0006895 3 0.011
sensory perception GO:0007600 245 0.011
protein targeting to vacuole GO:0006623 3 0.011
vesicle organization GO:0016050 60 0.011
leukocyte activation involved in immune response GO:0002366 126 0.011
regulation of cellular ketone metabolic process GO:0010565 66 0.011
negative regulation of kinase activity GO:0033673 81 0.011
sequestering of calcium ion GO:0051208 18 0.011
intermediate filament cytoskeleton organization GO:0045104 26 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
negative regulation of lymphocyte activation GO:0051250 91 0.011
ribonucleotide metabolic process GO:0009259 291 0.011
dna repair GO:0006281 107 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
lung development GO:0030324 164 0.011
convergent extension GO:0060026 14 0.011
cellular transition metal ion homeostasis GO:0046916 32 0.011
regulation of secretion GO:0051046 274 0.011
iron ion homeostasis GO:0055072 36 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
calcium ion homeostasis GO:0055074 127 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
cell division GO:0051301 120 0.011
microtubule based movement GO:0007018 84 0.011
cellularization GO:0007349 1 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.011
negative regulation of cell growth GO:0030308 44 0.011
multi multicellular organism process GO:0044706 109 0.011
regulation of histone h3 k9 methylation GO:0051570 8 0.011
negative regulation of neuron death GO:1901215 98 0.011
lymphocyte differentiation GO:0030098 242 0.010
positive regulation of protein catabolic process GO:0045732 60 0.010
negative regulation of synapse assembly GO:0051964 3 0.010
cellular response to organic cyclic compound GO:0071407 87 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
synapsis GO:0007129 34 0.010
negative regulation of chromatin silencing GO:0031936 1 0.010
divalent metal ion transport GO:0070838 172 0.010
regulation of bmp signaling pathway GO:0030510 60 0.010
positive regulation of intracellular transport GO:0032388 70 0.010
positive regulation of wnt signaling pathway GO:0030177 45 0.010
regulation of axon extension GO:0030516 43 0.010

Tab3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.071
disease of cellular proliferation DOID:14566 0 0.071
organ system cancer DOID:0050686 0 0.071
nervous system disease DOID:863 0 0.023
disease of anatomical entity DOID:7 0 0.023
thoracic cancer DOID:5093 0 0.014
musculoskeletal system disease DOID:17 0 0.013