Mus musculus

66 known processes

Tardbp

TAR DNA binding protein

(Aliases: C85084,Tdp43,TDP-43,1190002A23Rik)

Tardbp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna splicing GO:0008380 54 0.972
Human
mrna splicing via spliceosome GO:0000398 43 0.942
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.910
rna splicing via transesterification reactions GO:0000375 43 0.820
regulation of mrna splicing via spliceosome GO:0048024 32 0.818
mrna metabolic process GO:0016071 84 0.801
rna processing GO:0006396 105 0.772
Human
germ cell development GO:0007281 185 0.714
spermatid differentiation GO:0048515 115 0.673
nucleic acid transport GO:0050657 18 0.586
mrna processing GO:0006397 63 0.564
regulation of rna splicing GO:0043484 37 0.534
mrna export from nucleus GO:0006406 11 0.413
regulation of mrna metabolic process GO:1903311 43 0.409
male gamete generation GO:0048232 285 0.403
negative regulation of mrna splicing via spliceosome GO:0048025 12 0.390
oocyte construction GO:0007308 2 0.357
spliceosomal complex assembly GO:0000245 6 0.350
nucleobase containing compound transport GO:0015931 27 0.321
posttranscriptional gene silencing by rna GO:0035194 10 0.298
regulation of mrna processing GO:0050684 41 0.297
regulation of organelle organization GO:0033043 289 0.295
mitotic nuclear division GO:0007067 48 0.280
alternative mrna splicing via spliceosome GO:0000380 12 0.278
regulation of translation GO:0006417 71 0.276
development of primary sexual characteristics GO:0045137 143 0.267
negative regulation of cellular protein metabolic process GO:0032269 247 0.263
translation GO:0006412 93 0.256
mitotic cell cycle GO:0000278 195 0.253
spermatogenesis GO:0007283 284 0.251
negative regulation of rna splicing GO:0033119 12 0.244
rna transport GO:0050658 18 0.234
gene silencing by rna GO:0031047 19 0.222
regulation of cell cycle GO:0051726 281 0.216
posttranscriptional regulation of gene expression GO:0010608 155 0.213
Human
regulation of dna templated transcription termination GO:0031554 1 0.199
mrna transport GO:0051028 13 0.192
negative regulation of mrna metabolic process GO:1903312 13 0.180
spermatid development GO:0007286 108 0.178
rna interference GO:0016246 2 0.159
cell division GO:0051301 120 0.156
cytoplasmic transport GO:0016482 234 0.152
negative regulation of mrna processing GO:0050686 12 0.151
gonad development GO:0008406 141 0.141
regulation of mrna stability GO:0043488 23 0.141
Human
3 utr mediated mrna stabilization GO:0070935 2 0.132
Human
response to heat GO:0009408 27 0.125
regulation of cell cycle process GO:0010564 160 0.122
protein complex disassembly GO:0043241 40 0.120
cellular nitrogen compound catabolic process GO:0044270 280 0.117
ribonucleoprotein complex subunit organization GO:0071826 28 0.113
establishment of rna localization GO:0051236 18 0.113
negative regulation of protein metabolic process GO:0051248 282 0.111
organic cyclic compound catabolic process GO:1901361 295 0.106
genitalia development GO:0048806 37 0.102
nuclear division GO:0000280 158 0.101
oocyte axis specification GO:0007309 2 0.101
ras protein signal transduction GO:0007265 77 0.100
response to molecule of bacterial origin GO:0002237 143 0.098
nitrogen compound transport GO:0071705 271 0.093
regulation of protein complex disassembly GO:0043244 28 0.093
regulation of neuron projection development GO:0010975 169 0.093
dendrite development GO:0016358 115 0.092
stem cell development GO:0048864 219 0.085
mitotic cell cycle process GO:1903047 159 0.084
microtubule cytoskeleton organization GO:0000226 157 0.081
rna localization GO:0006403 23 0.074
inflammatory response GO:0006954 244 0.074
dna templated transcription termination GO:0006353 4 0.072
heterocycle catabolic process GO:0046700 280 0.071
regionalization GO:0003002 337 0.070
rna stabilization GO:0043489 9 0.069
Human
regulation of alternative mrna splicing via spliceosome GO:0000381 8 0.069
female gamete generation GO:0007292 74 0.068
regulation of rna stability GO:0043487 26 0.063
Human
organelle fission GO:0048285 170 0.061
organelle localization GO:0051640 179 0.060
nuclear transport GO:0051169 139 0.058
regulation of cytoskeleton organization GO:0051493 122 0.057
oocyte anterior posterior axis specification GO:0007314 2 0.057
oogenesis GO:0048477 56 0.055
rna 3 end processing GO:0031123 20 0.054
meiotic cell cycle GO:0051321 122 0.054
oocyte development GO:0048599 33 0.053
developmental maturation GO:0021700 193 0.051
regulation of mitotic cell cycle GO:0007346 126 0.051
nucleocytoplasmic transport GO:0006913 139 0.050
striated muscle contraction GO:0006941 45 0.049
adult locomotory behavior GO:0008344 91 0.048
Fly
amine metabolic process GO:0009308 45 0.047
mrna splice site selection GO:0006376 5 0.047
stem cell differentiation GO:0048863 268 0.046
mrna catabolic process GO:0006402 22 0.046
cellular amine metabolic process GO:0044106 44 0.045
aromatic compound catabolic process GO:0019439 286 0.045
muscle contraction GO:0006936 101 0.045
rna catabolic process GO:0006401 29 0.044
establishment of organelle localization GO:0051656 122 0.044
nuclear export GO:0051168 34 0.043
skin development GO:0043588 220 0.041
response to lipopolysaccharide GO:0032496 128 0.041
ribonucleotide metabolic process GO:0009259 291 0.040
ribonucleoside triphosphate metabolic process GO:0009199 220 0.039
circulatory system process GO:0003013 197 0.039
ribonucleoprotein complex localization GO:0071166 1 0.037
intracellular protein transport GO:0006886 204 0.037
negative regulation of dna templated transcription termination GO:0060567 1 0.037
response to temperature stimulus GO:0009266 55 0.036
regulation of protein localization GO:0032880 231 0.036
multi multicellular organism process GO:0044706 109 0.036
macromolecular complex disassembly GO:0032984 43 0.034
maternal determination of anterior posterior axis embryo GO:0008358 2 0.033
positive regulation of organelle organization GO:0010638 128 0.033
cellular macromolecule catabolic process GO:0044265 206 0.032
regulation of nuclear division GO:0051783 56 0.032
meiotic nuclear division GO:0007126 115 0.032
positive regulation of chromosome organization GO:2001252 33 0.032
termination of rna polymerase ii transcription GO:0006369 1 0.032
oxidation reduction process GO:0055114 342 0.031
regulation of cellular component biogenesis GO:0044087 181 0.031
Fly
nucleotide catabolic process GO:0009166 217 0.030
regulation of apoptotic signaling pathway GO:2001233 197 0.030
protein localization to nucleus GO:0034504 121 0.030
multicellular organismal aging GO:0010259 24 0.030
nucleoside phosphate catabolic process GO:1901292 222 0.029
multicellular organism growth GO:0035264 161 0.029
negative regulation of cellular component organization GO:0051129 194 0.029
Fly
ossification GO:0001503 216 0.028
hematopoietic progenitor cell differentiation GO:0002244 143 0.027
atp catabolic process GO:0006200 55 0.027
regulation of cellular response to stress GO:0080135 159 0.026
membrane organization GO:0061024 245 0.026
purine nucleoside metabolic process GO:0042278 241 0.025
positive regulation of cell development GO:0010720 237 0.025
stem cell maintenance GO:0019827 130 0.025
regulation of cell division GO:0051302 76 0.025
cell maturation GO:0048469 127 0.025
cell junction organization GO:0034330 77 0.025
macromolecule catabolic process GO:0009057 281 0.024
ribonucleoside metabolic process GO:0009119 245 0.024
cellular response to lipopolysaccharide GO:0071222 77 0.024
microtubule based process GO:0007017 236 0.023
nucleoside monophosphate metabolic process GO:0009123 85 0.023
cellular ketone metabolic process GO:0042180 84 0.023
determination of adult lifespan GO:0008340 11 0.023
pole plasm assembly GO:0007315 2 0.023
nuclear mrna surveillance GO:0071028 1 0.022
protein localization to organelle GO:0033365 185 0.022
epidermis development GO:0008544 187 0.022
protein oligomerization GO:0051259 67 0.022
negative regulation of cell cycle GO:0045786 123 0.022
regulation of cell cycle phase transition GO:1901987 77 0.022
purine containing compound metabolic process GO:0072521 311 0.022
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 1 0.021
actin cytoskeleton organization GO:0030036 220 0.021
development of primary female sexual characteristics GO:0046545 73 0.021
regulation of cellular amine metabolic process GO:0033238 20 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
apoptotic signaling pathway GO:0097190 306 0.020
cellular amino acid metabolic process GO:0006520 103 0.020
adult behavior GO:0030534 135 0.020
Fly
body morphogenesis GO:0010171 45 0.020
protein maturation GO:0051604 176 0.020
regulation of cell projection organization GO:0031344 206 0.020
positive regulation of rna splicing GO:0033120 12 0.019
negative regulation of protein modification process GO:0031400 163 0.019
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 1 0.019
cellular protein complex disassembly GO:0043624 36 0.019
positive regulation of neuron differentiation GO:0045666 141 0.019
positive regulation of proteolysis GO:0045862 85 0.019
regulation of ras protein signal transduction GO:0046578 114 0.019
nucleoside metabolic process GO:0009116 246 0.019
small gtpase mediated signal transduction GO:0007264 97 0.019
epithelial cell proliferation GO:0050673 174 0.019
chemotaxis GO:0006935 247 0.019
purine nucleotide catabolic process GO:0006195 211 0.018
endocytosis GO:0006897 168 0.018
intracellular mrna localization GO:0008298 4 0.018
negative regulation of keratinocyte differentiation GO:0045617 4 0.017
response to organonitrogen compound GO:0010243 246 0.017
posttranscriptional gene silencing GO:0016441 10 0.017
nucleus organization GO:0006997 45 0.017
regulation of system process GO:0044057 200 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
maintenance of location GO:0051235 89 0.016
phospholipid metabolic process GO:0006644 87 0.016
compound eye development GO:0048749 1 0.016
cell growth GO:0016049 130 0.016
Zebrafish
regulation of epidermis development GO:0045682 33 0.016
negative regulation of cell cycle process GO:0010948 69 0.016
heart process GO:0003015 94 0.016
anatomical structure homeostasis GO:0060249 145 0.015
negative regulation of translation GO:0017148 22 0.015
female sex differentiation GO:0046660 84 0.015
circadian rhythm GO:0007623 114 0.015
protein localization to membrane GO:0072657 108 0.015
positive regulation of growth GO:0045927 104 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
cellular response to organonitrogen compound GO:0071417 145 0.015
ribosomal subunit export from nucleus GO:0000054 1 0.015
fertilization GO:0009566 127 0.014
axonogenesis GO:0007409 274 0.014
Zebrafish
cellular protein complex assembly GO:0043623 116 0.014
myosin filament organization GO:0031033 3 0.014
blood circulation GO:0008015 195 0.014
positive regulation of mrna processing GO:0050685 16 0.014
cellularization GO:0007349 1 0.014
neuron projection guidance GO:0097485 141 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
pore complex assembly GO:0046931 3 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
positive regulation of nervous system development GO:0051962 221 0.013
negative regulation of molecular function GO:0044092 258 0.013
positive regulation of mrna metabolic process GO:1903313 17 0.013
female gonad development GO:0008585 71 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
regulation of meiotic cell cycle GO:0051445 34 0.013
lipid localization GO:0010876 126 0.013
positive regulation of dendrite development GO:1900006 21 0.013
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.013
myeloid cell differentiation GO:0030099 233 0.013
gene silencing GO:0016458 38 0.012
positive regulation of cellular amine metabolic process GO:0033240 5 0.012
dna metabolic process GO:0006259 303 0.012
cell type specific apoptotic process GO:0097285 268 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
generation of precursor metabolites and energy GO:0006091 103 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of multi organism process GO:0043900 111 0.012
Human
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
purine nucleoside catabolic process GO:0006152 205 0.012
regulation of actin filament based process GO:0032970 99 0.011
protein import into nucleus GO:0006606 95 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
organophosphate catabolic process GO:0046434 232 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
segmentation GO:0035282 93 0.011
nucleobase containing small molecule metabolic process GO:0055086 352 0.011
poly a mrna export from nucleus GO:0016973 4 0.011
regulation of anatomical structure size GO:0090066 178 0.011
regulation of cellular component size GO:0032535 121 0.011
regulation of protein transport GO:0051223 163 0.011
nucleoside catabolic process GO:0009164 206 0.011
organelle assembly GO:0070925 177 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
regulation of transferase activity GO:0051338 263 0.010
regulation of chromatin modification GO:1903308 57 0.010
positive regulation of mrna splicing via spliceosome GO:0048026 11 0.010
regulation of mitotic cell cycle phase transition GO:1901990 73 0.010
nucleoside monophosphate catabolic process GO:0009125 59 0.010
neuron migration GO:0001764 122 0.010
negative regulation of nervous system development GO:0051961 156 0.010
Fly
ribonucleoside triphosphate catabolic process GO:0009203 199 0.010

Tardbp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.049
Human
disease of anatomical entity DOID:7 0 0.049
Human
nervous system disease DOID:863 0 0.049
Human
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
musculoskeletal system disease DOID:17 0 0.016
muscle tissue disease DOID:66 0 0.016