Mus musculus

97 known processes

Tbk1

TANK-binding kinase 1

(Aliases: AW048562,MGC150302,1200008B05Rik,MGC150301,AI462036)

Tbk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dendritic cell proliferation GO:0044565 2 0.823
i kappab kinase nf kappab signaling GO:0007249 85 0.732
Human Mouse
leukocyte proliferation GO:0070661 172 0.535
purine nucleoside triphosphate catabolic process GO:0009146 203 0.461
cytokine production GO:0001816 319 0.389
nucleoside phosphate metabolic process GO:0006753 338 0.379
inflammatory response GO:0006954 244 0.335
positive regulation of cytokine production GO:0001819 174 0.324
activation of immune response GO:0002253 138 0.321
nucleoside triphosphate metabolic process GO:0009141 230 0.296
epithelial tube formation GO:0072175 130 0.264
organic cyclic compound catabolic process GO:1901361 295 0.259
t cell activation GO:0042110 289 0.256
response to organonitrogen compound GO:0010243 246 0.246
regulation of neuron differentiation GO:0045664 281 0.243
neutrophil degranulation GO:0043312 6 0.231
regulation of innate immune response GO:0045088 91 0.230
regulation of lymphocyte activation GO:0051249 240 0.226
nucleoside triphosphate catabolic process GO:0009143 205 0.216
antibacterial peptide production GO:0002778 2 0.212
purine nucleoside metabolic process GO:0042278 241 0.210
immune response activating signal transduction GO:0002757 116 0.208
vesicle organization GO:0016050 60 0.203
neuron apoptotic process GO:0051402 142 0.201
ribonucleoside triphosphate metabolic process GO:0009199 220 0.191
cell type specific apoptotic process GO:0097285 268 0.189
morphogenesis of embryonic epithelium GO:0016331 159 0.182
purine nucleotide catabolic process GO:0006195 211 0.181
protein modification by small protein conjugation GO:0032446 187 0.171
positive regulation of secretion GO:0051047 130 0.171
purine containing compound metabolic process GO:0072521 311 0.157
embryonic epithelial tube formation GO:0001838 130 0.154
axonogenesis GO:0007409 274 0.150
nucleobase containing small molecule metabolic process GO:0055086 352 0.143
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.137
positive regulation of cell death GO:0010942 224 0.135
Fly
negative regulation of t cell activation GO:0050868 65 0.134
immune response regulating signaling pathway GO:0002764 125 0.133
peptidyl amino acid modification GO:0018193 336 0.132
Fly
regulation of cytokine production GO:0001817 266 0.132
leukocyte differentiation GO:0002521 342 0.128
Mouse
single organismal cell cell adhesion GO:0016337 131 0.128
heart morphogenesis GO:0003007 178 0.127
positive regulation of innate immune response GO:0045089 80 0.123
pigmentation GO:0043473 71 0.117
immune response in mucosal associated lymphoid tissue GO:0002386 2 0.117
response to organic cyclic compound GO:0014070 198 0.116
lymphocyte proliferation GO:0046651 164 0.116
response to peptide GO:1901652 136 0.116
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.113
nucleoside monophosphate metabolic process GO:0009123 85 0.113
nucleoside metabolic process GO:0009116 246 0.107
regulation of inflammatory response GO:0050727 147 0.107
regulation of t cell activation GO:0050863 170 0.105
neural tube development GO:0021915 160 0.103
regulation of neuron apoptotic process GO:0043523 122 0.101
nucleoside phosphate catabolic process GO:1901292 222 0.101
activation of innate immune response GO:0002218 56 0.101
tumor necrosis factor production GO:0032640 50 0.101
ribonucleoside monophosphate metabolic process GO:0009161 80 0.099
epidermis development GO:0008544 187 0.095
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.095
regulation of protein processing GO:0070613 96 0.095
response to peptide hormone GO:0043434 127 0.094
glycosyl compound metabolic process GO:1901657 246 0.093
cellular response to cytokine stimulus GO:0071345 189 0.093
regulation of cell activation GO:0050865 289 0.092
negative regulation of neuron apoptotic process GO:0043524 92 0.092
regulation of secretion GO:0051046 274 0.092
purine nucleoside triphosphate metabolic process GO:0009144 226 0.092
wound healing GO:0042060 157 0.092
nucleotide metabolic process GO:0009117 332 0.091
heterocycle catabolic process GO:0046700 280 0.090
positive regulation of apoptotic process GO:0043065 217 0.089
Fly
negative regulation of cellular amine metabolic process GO:0033239 1 0.088
carbohydrate derivative catabolic process GO:1901136 231 0.086
regulation of secretion by cell GO:1903530 249 0.086
negative regulation of cell proliferation GO:0008285 296 0.085
ribonucleoside metabolic process GO:0009119 245 0.085
positive regulation of hydrolase activity GO:0051345 148 0.083
Fly
hormone secretion GO:0046879 128 0.083
angiogenesis GO:0001525 201 0.083
cellular lipid metabolic process GO:0044255 323 0.083
ribonucleoside catabolic process GO:0042454 206 0.082
response to insulin GO:0032868 100 0.082
cell adhesion GO:0007155 329 0.080
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.079
positive regulation of growth GO:0045927 104 0.079
aromatic compound catabolic process GO:0019439 286 0.079
regulation of cellular component size GO:0032535 121 0.078
neurotransmitter secretion GO:0007269 62 0.078
regulation of cell migration GO:0030334 219 0.076
neuron death GO:0070997 154 0.076
regulation of leukocyte differentiation GO:1902105 159 0.076
carbohydrate homeostasis GO:0033500 128 0.076
regulation of endopeptidase activity GO:0052548 89 0.074
Fly
cation transport GO:0006812 399 0.073
Mouse
interleukin 6 production GO:0032635 58 0.073
myeloid leukocyte activation GO:0002274 83 0.073
positive regulation of cell development GO:0010720 237 0.072
regulation of purine nucleotide metabolic process GO:1900542 169 0.069
positive regulation of smooth muscle cell migration GO:0014911 4 0.069
somite specification GO:0001757 4 0.068
regulation of endocytosis GO:0030100 69 0.068
innate immune response activating signal transduction GO:0002758 50 0.066
regulation of nucleoside metabolic process GO:0009118 130 0.066
rho protein signal transduction GO:0007266 32 0.066
positive regulation of defense response GO:0031349 124 0.065
regulation of insulin receptor signaling pathway GO:0046626 21 0.065
regulation of t cell differentiation GO:0045580 83 0.065
regionalization GO:0003002 337 0.063
regulation of cellular ketone metabolic process GO:0010565 66 0.062
protein ubiquitination GO:0016567 171 0.062
ribose phosphate metabolic process GO:0019693 291 0.062
regulation of ion transmembrane transporter activity GO:0032412 54 0.062
Mouse
regulation of synaptic vesicle transport GO:1902803 13 0.062
regulation of t cell proliferation GO:0042129 92 0.061
cellular nitrogen compound catabolic process GO:0044270 280 0.061
regulation of exocytosis GO:0017157 61 0.060
negative regulation of neuron death GO:1901215 98 0.059
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.059
tube formation GO:0035148 140 0.058
stem cell differentiation GO:0048863 268 0.058
regulation of protein maturation GO:1903317 96 0.058
exocytosis GO:0006887 121 0.058
regulation of response to wounding GO:1903034 189 0.056
methylation GO:0032259 134 0.056
positive regulation of protein modification process GO:0031401 299 0.056
regulation of nucleotide metabolic process GO:0006140 169 0.055
purine ribonucleoside metabolic process GO:0046128 241 0.055
negative regulation of cellular component organization GO:0051129 194 0.055
protein processing GO:0016485 163 0.054
regulation of neuron projection development GO:0010975 169 0.054
epithelial tube morphogenesis GO:0060562 303 0.054
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.053
regulation of organ morphogenesis GO:2000027 144 0.053
peptidyl serine modification GO:0018209 83 0.053
Fly
cellular amino acid metabolic process GO:0006520 103 0.053
maintenance of location GO:0051235 89 0.052
regulation of cellular amino acid metabolic process GO:0006521 5 0.052
purine nucleotide metabolic process GO:0006163 302 0.052
positive regulation of antimicrobial humoral response GO:0002760 2 0.051
lipid storage GO:0019915 36 0.051
purine ribonucleotide catabolic process GO:0009154 208 0.051
regulation of anatomical structure size GO:0090066 178 0.051
cellular amine metabolic process GO:0044106 44 0.050
regulation of defense response GO:0031347 233 0.050
purine ribonucleoside catabolic process GO:0046130 205 0.050
regulation of reactive oxygen species metabolic process GO:2000377 40 0.050
developmental maturation GO:0021700 193 0.050
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.049
regulation of cellular component biogenesis GO:0044087 181 0.049
synaptic vesicle localization GO:0097479 59 0.049
regulation of cytokine biosynthetic process GO:0042035 59 0.049
regulation of nucleotide catabolic process GO:0030811 122 0.048
striated muscle tissue development GO:0014706 293 0.048
cell aging GO:0007569 35 0.048
regulation of body fluid levels GO:0050878 162 0.048
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.048
protein maturation GO:0051604 176 0.047
cellular response to lipopolysaccharide GO:0071222 77 0.047
amine metabolic process GO:0009308 45 0.047
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
purine ribonucleotide metabolic process GO:0009150 290 0.046
purine nucleoside catabolic process GO:0006152 205 0.045
negative regulation of molecular function GO:0044092 258 0.045
regulation of hydrolase activity GO:0051336 246 0.045
Fly
neural tube formation GO:0001841 108 0.044
regulation of ion transport GO:0043269 215 0.044
Mouse
negative regulation of growth GO:0045926 99 0.043
regulation of cell motility GO:2000145 236 0.043
response to lipopolysaccharide GO:0032496 128 0.043
establishment or maintenance of cell polarity GO:0007163 86 0.043
reactive oxygen species metabolic process GO:0072593 84 0.042
positive regulation of interferon beta production GO:0032728 8 0.042
synaptic transmission GO:0007268 329 0.042
fat cell differentiation GO:0045444 160 0.042
cytokine metabolic process GO:0042107 71 0.041
nuclear division GO:0000280 158 0.040
nucleoside monophosphate catabolic process GO:0009125 59 0.040
male gamete generation GO:0048232 285 0.040
protein localization to organelle GO:0033365 185 0.040
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.040
Fly
nucleoside catabolic process GO:0009164 206 0.040
positive regulation of nervous system development GO:0051962 221 0.040
neurotransmitter transport GO:0006836 76 0.040
negative regulation of hydrolase activity GO:0051346 71 0.039
positive regulation of programmed cell death GO:0043068 218 0.039
Fly
regulation of interferon beta biosynthetic process GO:0045357 4 0.039
hormone mediated signaling pathway GO:0009755 23 0.038
positive regulation of leukocyte differentiation GO:1902107 86 0.038
single organism cell adhesion GO:0098602 156 0.038
cellular macromolecule catabolic process GO:0044265 206 0.038
cellular response to organonitrogen compound GO:0071417 145 0.038
respiratory tube development GO:0030323 167 0.038
blood vessel morphogenesis GO:0048514 285 0.038
respiratory system development GO:0060541 190 0.038
Fly
pigment granule localization GO:0051875 13 0.037
lipid localization GO:0010876 126 0.037
positive regulation of cellular catabolic process GO:0031331 148 0.037
peptidyl tyrosine phosphorylation GO:0018108 143 0.037
regulation of production of molecular mediator of immune response GO:0002700 65 0.037
regulation of cell growth GO:0001558 91 0.036
positive regulation of cytokine biosynthetic process GO:0042108 40 0.036
organophosphate catabolic process GO:0046434 232 0.035
neuronal action potential GO:0019228 54 0.035
nitrogen compound transport GO:0071705 271 0.035
ribonucleotide catabolic process GO:0009261 208 0.035
positive regulation of lymphocyte activation GO:0051251 140 0.035
regulation of cytoskeleton organization GO:0051493 122 0.035
Fly
cellular ketone metabolic process GO:0042180 84 0.035
cellular response to biotic stimulus GO:0071216 92 0.035
mammary gland epithelium development GO:0061180 65 0.034
Mouse
regulation of cellular response to insulin stimulus GO:1900076 30 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.034
regulation of cell projection organization GO:0031344 206 0.034
immunoglobulin transcytosis in epithelial cells GO:0002414 2 0.034
synaptic vesicle maturation GO:0016188 7 0.033
membrane organization GO:0061024 245 0.033
positive regulation of toll like receptor 4 signaling pathway GO:0034145 1 0.032
negative regulation of immune system process GO:0002683 209 0.032
covalent chromatin modification GO:0016569 163 0.032
vesicle docking involved in exocytosis GO:0006904 7 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.032
regulation of protein localization GO:0032880 231 0.032
morphogenesis of a polarized epithelium GO:0001738 37 0.032
cellular response to molecule of bacterial origin GO:0071219 83 0.032
positive regulation of sequestering of triglyceride GO:0010890 4 0.032
glycosyl compound catabolic process GO:1901658 206 0.031
spermatogenesis GO:0007283 284 0.031
somitogenesis GO:0001756 69 0.031
interspecies interaction between organisms GO:0044419 83 0.031
homeostasis of number of cells GO:0048872 210 0.031
Mouse
dna metabolic process GO:0006259 303 0.031
positive regulation of protein phosphorylation GO:0001934 242 0.030
ribonucleotide metabolic process GO:0009259 291 0.030
cellular response to arsenic containing substance GO:0071243 4 0.030
mammary gland epithelial cell proliferation GO:0033598 24 0.030
Mouse
negative regulation of protein maturation GO:1903318 79 0.030
purine nucleoside monophosphate metabolic process GO:0009126 81 0.030
t cell differentiation GO:0030217 174 0.030
small gtpase mediated signal transduction GO:0007264 97 0.029
calcium ion dependent exocytosis GO:0017156 35 0.029
modification dependent macromolecule catabolic process GO:0043632 133 0.029
protein kinase b signaling GO:0043491 74 0.029
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.028
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.028
Fly
regulation of t cell differentiation in thymus GO:0033081 24 0.028
metal ion homeostasis GO:0055065 189 0.028
synaptic vesicle recycling GO:0036465 19 0.028
nucleotide catabolic process GO:0009166 217 0.028
protein polymerization GO:0051258 57 0.028
multi multicellular organism process GO:0044706 109 0.028
regulation of ossification GO:0030278 112 0.028
mapk cascade GO:0000165 281 0.028
organelle fusion GO:0048284 28 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
cellular protein catabolic process GO:0044257 155 0.028
cytokine biosynthetic process GO:0042089 68 0.027
antigen receptor mediated signaling pathway GO:0050851 64 0.027
regulation of platelet derived growth factor receptor beta signaling pathway GO:2000586 2 0.027
regulation of lymphocyte differentiation GO:0045619 107 0.027
action potential GO:0001508 78 0.027
negative regulation of intracellular signal transduction GO:1902532 167 0.027
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.027
regulation of protein transport GO:0051223 163 0.027
organophosphate biosynthetic process GO:0090407 122 0.027
regulated secretory pathway GO:0045055 32 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
immune effector process GO:0002252 321 0.027
meiotic cell cycle GO:0051321 122 0.026
regulation of neuron death GO:1901214 134 0.026
regulation of cellular amine metabolic process GO:0033238 20 0.026
endocytosis GO:0006897 168 0.026
extrinsic apoptotic signaling pathway GO:0097191 126 0.026
regulation of antibacterial peptide production GO:0002786 1 0.026
spermatid differentiation GO:0048515 115 0.026
t cell proliferation GO:0042098 120 0.026
ribonucleoside triphosphate catabolic process GO:0009203 199 0.026
regulation of protein kinase b signaling GO:0051896 56 0.026
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.026
rhythmic process GO:0048511 174 0.026
embryonic organ morphogenesis GO:0048562 276 0.026
negative regulation of lymphocyte activation GO:0051250 91 0.026
negative regulation of cytokine production GO:0001818 84 0.026
microtubule based process GO:0007017 236 0.025
Fly
modification dependent protein catabolic process GO:0019941 133 0.025
response to nutrient levels GO:0031667 109 0.025
negative regulation of cell activation GO:0050866 111 0.025
response to oxidative stress GO:0006979 123 0.025
pattern recognition receptor signaling pathway GO:0002221 47 0.025
epithelial cell development GO:0002064 159 0.025
organelle localization GO:0051640 179 0.025
positive regulation of gtpase activity GO:0043547 85 0.025
establishment of protein localization to organelle GO:0072594 118 0.025
amide transport GO:0042886 138 0.025
organonitrogen compound catabolic process GO:1901565 264 0.024
primary neural tube formation GO:0014020 95 0.024
muscle tissue development GO:0060537 308 0.024
negative regulation of proteolysis GO:0045861 74 0.024
non canonical wnt signaling pathway GO:0035567 33 0.023
peptide secretion GO:0002790 114 0.023
intracellular cholesterol transport GO:0032367 3 0.023
regulation of neurotransmitter secretion GO:0046928 29 0.023
muscle cell differentiation GO:0042692 261 0.023
regulation of androgen receptor signaling pathway GO:0060765 3 0.023
notch signaling pathway GO:0007219 71 0.023
regulation of cell cycle GO:0051726 281 0.023
positive regulation of engulfment of apoptotic cell GO:1901076 1 0.023
neural tube closure GO:0001843 90 0.023
cellular response to peptide hormone stimulus GO:0071375 92 0.023
cellular homeostasis GO:0019725 240 0.023
response to molecule of bacterial origin GO:0002237 143 0.023
apoptotic signaling pathway GO:0097190 306 0.022
embryonic appendage morphogenesis GO:0035113 126 0.022
ribonucleoside monophosphate catabolic process GO:0009158 57 0.022
circadian rhythm GO:0007623 114 0.022
negative regulation of protein processing GO:0010955 79 0.022
regulation of cell size GO:0008361 72 0.022
organelle fission GO:0048285 170 0.022
skin development GO:0043588 220 0.022
regulation of synaptic transmission gabaergic GO:0032228 17 0.022
regulation of hormone levels GO:0010817 211 0.022
mitotic cell cycle GO:0000278 195 0.022
negative regulation of endopeptidase activity GO:0010951 44 0.022
digestive system development GO:0055123 200 0.022
interferon beta biosynthetic process GO:0045350 4 0.021
positive regulation of interleukin 6 production GO:0032755 37 0.021
neuromuscular synaptic transmission GO:0007274 16 0.021
regulation of ion transmembrane transport GO:0034765 119 0.021
Mouse
establishment of pigment granule localization GO:0051905 12 0.021
peptidyl tyrosine modification GO:0018212 145 0.021
somite development GO:0061053 81 0.021
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.021
developmental growth involved in morphogenesis GO:0060560 138 0.021
granulocyte activation GO:0036230 10 0.021
t cell differentiation in thymus GO:0033077 77 0.021
cellular response to insulin stimulus GO:0032869 78 0.021
myeloid leukocyte differentiation GO:0002573 119 0.021
Mouse
positive regulation of proteolysis GO:0045862 85 0.021
Fly
macromolecule methylation GO:0043414 120 0.021
regulation of lymphocyte proliferation GO:0050670 117 0.021
cell substrate adhesion GO:0031589 130 0.021
positive regulation of apoptotic signaling pathway GO:2001235 95 0.021
humoral immune response GO:0006959 57 0.021
negative regulation of tor signaling GO:0032007 13 0.021
synaptic transmission gabaergic GO:0051932 19 0.021
regulation of intracellular protein transport GO:0033157 82 0.021
cardiac ventricle development GO:0003231 83 0.021
phospholipid metabolic process GO:0006644 87 0.020
regulation of purine nucleotide catabolic process GO:0033121 122 0.020
epithelial cell proliferation GO:0050673 174 0.020
Mouse
b cell activation GO:0042113 161 0.020
actin cytoskeleton organization GO:0030036 220 0.020
Fly
negative regulation of cell development GO:0010721 169 0.020
regulation of transferase activity GO:0051338 263 0.020
macromolecule catabolic process GO:0009057 281 0.020
defense response to virus GO:0051607 68 0.020
establishment of protein localization to vacuole GO:0072666 4 0.020
positive regulation of peptidase activity GO:0010952 49 0.020
Fly
negative regulation of inflammatory response GO:0050728 61 0.020
negative regulation of neuron differentiation GO:0045665 101 0.020
necrotic cell death GO:0070265 30 0.020
forebrain neuron differentiation GO:0021879 52 0.020
cellular response to hormone stimulus GO:0032870 150 0.020
atp metabolic process GO:0046034 75 0.020
leukocyte mediated immunity GO:0002443 174 0.020
regulation of membrane potential GO:0042391 192 0.020
establishment of synaptic vesicle localization GO:0097480 57 0.020
regulation of synaptic vesicle exocytosis GO:2000300 11 0.020
regulation of carbohydrate biosynthetic process GO:0043255 40 0.020
toll like receptor 3 signaling pathway GO:0034138 4 0.020
cellular response to interleukin 15 GO:0071350 2 0.020
regulation of mapk cascade GO:0043408 248 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
interferon gamma mediated signaling pathway GO:0060333 5 0.019
positive regulation of cell adhesion GO:0045785 80 0.019
cellular response to peptide GO:1901653 92 0.019
insulin secretion GO:0030073 89 0.019
protein localization to endosome GO:0036010 2 0.019
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
cell maturation GO:0048469 127 0.019
Fly
protein localization to vacuole GO:0072665 4 0.019
syncytium formation by plasma membrane fusion GO:0000768 42 0.019
lymphocyte differentiation GO:0030098 242 0.019
molting cycle GO:0042303 90 0.019
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.018
cell fate commitment GO:0045165 210 0.018
development of primary sexual characteristics GO:0045137 143 0.018
negative regulation of peptidase activity GO:0010466 46 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.018
chromatin organization GO:0006325 206 0.018
regulation of metal ion transport GO:0010959 106 0.018
Mouse
cellular response to lipid GO:0071396 145 0.018
locomotory behavior GO:0007626 195 0.018
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.018
embryonic heart tube development GO:0035050 65 0.018
positive regulation of protein kinase b signaling GO:0051897 32 0.018
positive regulation of kinase activity GO:0033674 155 0.018
positive regulation of nucleoside metabolic process GO:0045979 91 0.018
neutrophil mediated immunity GO:0002446 19 0.018
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.018
gland development GO:0048732 330 0.018
Mouse
multicellular organismal signaling GO:0035637 91 0.017
interferon gamma production GO:0032609 67 0.017
gtp catabolic process GO:0006184 143 0.017
cell growth GO:0016049 130 0.017
glucose homeostasis GO:0042593 128 0.017
intracellular sterol transport GO:0032366 3 0.017
axon target recognition GO:0007412 4 0.017
regulation of vasculature development GO:1901342 88 0.017
antimicrobial peptide production GO:0002775 2 0.017
cardiac chamber development GO:0003205 108 0.017
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.017
hepatocyte growth factor receptor signaling pathway GO:0048012 3 0.017
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.017
guanosine containing compound catabolic process GO:1901069 144 0.017
monoubiquitinated histone h2a deubiquitination GO:0035522 1 0.017
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.017
peptidyl serine phosphorylation GO:0018105 74 0.016
Fly
establishment of tissue polarity GO:0007164 28 0.016
protein catabolic process GO:0030163 221 0.016
regulation of vesicle mediated transport GO:0060627 139 0.016
regulation of cysteine type endopeptidase activity GO:2000116 65 0.016
Fly
atp catabolic process GO:0006200 55 0.016
regulation of interleukin 6 production GO:0032675 55 0.016
response to tumor necrosis factor GO:0034612 26 0.016
diencephalon development GO:0021536 63 0.016
regulation of homeostatic process GO:0032844 182 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
cell division GO:0051301 120 0.016
Fly
apical constriction GO:0003383 4 0.016
protein retention in golgi apparatus GO:0045053 1 0.016
regulation of antimicrobial peptide production GO:0002784 1 0.016
regulation of tor signaling GO:0032006 17 0.016
response to acid chemical GO:0001101 111 0.016
establishment or maintenance of apical basal cell polarity GO:0035088 21 0.015
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.015
regulation of erk1 and erk2 cascade GO:0070372 71 0.015
b cell homeostasis GO:0001782 34 0.015
Mouse
protein targeting GO:0006605 143 0.015
actin filament based movement GO:0030048 23 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.015
cellular metal ion homeostasis GO:0006875 151 0.015
cellular protein complex assembly GO:0043623 116 0.015
wnt signaling pathway GO:0016055 188 0.015
tissue homeostasis GO:0001894 115 0.015
Fly
positive regulation of nucleotide catabolic process GO:0030813 88 0.015
spermatid development GO:0007286 108 0.015
negative regulation of protein metabolic process GO:0051248 282 0.015
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 1 0.015
canonical wnt signaling pathway GO:0060070 130 0.015
hematopoietic progenitor cell differentiation GO:0002244 143 0.015
regulation of multi organism process GO:0043900 111 0.014
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
organic hydroxy compound transport GO:0015850 93 0.014
positive regulation of exocytosis GO:0045921 20 0.014
positive regulation of neuron projection development GO:0010976 79 0.014
positive t cell selection GO:0043368 23 0.014
skeletal system development GO:0001501 356 0.014
regulation of organelle organization GO:0033043 289 0.014
Fly
positive regulation of lipid storage GO:0010884 10 0.014
response to steroid hormone GO:0048545 56 0.014
interleukin 2 mediated signaling pathway GO:0038110 2 0.014
positive regulation of defense response to virus by host GO:0002230 6 0.014
negative regulation of fatty acid transport GO:2000192 1 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.014
regulation of mitotic cell cycle phase transition GO:1901990 73 0.014
regulation of proteolysis GO:0030162 164 0.014
Fly
muscle atrophy GO:0014889 3 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
antimicrobial peptide biosynthetic process GO:0002777 2 0.014
purine containing compound catabolic process GO:0072523 213 0.014
regulation of leukocyte proliferation GO:0070663 121 0.014
regulation of protein complex assembly GO:0043254 83 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
establishment of planar polarity GO:0001736 28 0.014
regulation of gluconeogenesis GO:0006111 30 0.014
determination of heart left right asymmetry GO:0061371 48 0.013
regulation of antimicrobial humoral response GO:0002759 3 0.013
cellular response to oxidative stress GO:0034599 76 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
negative regulation of cell motility GO:2000146 61 0.013
lymphocyte homeostasis GO:0002260 64 0.013
Mouse

Tbk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.073
disease of cellular proliferation DOID:14566 0 0.073
organ system cancer DOID:0050686 0 0.036
bone disease DOID:0080001 0 0.019
disease of anatomical entity DOID:7 0 0.019
musculoskeletal system disease DOID:17 0 0.019
connective tissue disease DOID:65 0 0.019
large intestine cancer DOID:5672 0 0.015
colon cancer DOID:219 0 0.015
gastrointestinal system cancer DOID:3119 0 0.015
intestinal cancer DOID:10155 0 0.015
colorectal cancer DOID:9256 0 0.015