Mus musculus

34 known processes

Tbx4

T-box 4

(Aliases: 3930401C23)

Tbx4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
hypothalamus cell migration GO:0021855 5 0.973
hindlimb morphogenesis GO:0035137 42 0.942
Mouse
limb morphogenesis GO:0035108 149 0.936
limb development GO:0060173 166 0.926
dorsal ventral axon guidance GO:0033563 3 0.900
appendage morphogenesis GO:0035107 149 0.827
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.755
Mouse
sinoatrial node cell differentiation GO:0060921 3 0.725
Mouse
branchiomeric skeletal muscle development GO:0014707 3 0.723
skeletal system development GO:0001501 356 0.697
Mouse
left lung morphogenesis GO:0060460 3 0.669
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.647
Mouse
regulation of tongue muscle cell differentiation GO:2001035 2 0.539
Mouse
skeletal system morphogenesis GO:0048705 203 0.510
Mouse
vagus nerve development GO:0021564 3 0.503
Mouse
regulation of muscle tissue development GO:1901861 97 0.495
Mouse
mammary placode formation GO:0060596 4 0.493
Mouse
muscle tissue development GO:0060537 308 0.475
Mouse
sinoatrial node cell development GO:0060931 3 0.474
Mouse
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.470
Mouse
extraocular skeletal muscle development GO:0002074 2 0.468
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.447
Mouse
vascular smooth muscle cell differentiation GO:0035886 11 0.447
camera type eye development GO:0043010 266 0.443
Mouse
regulation of myotube differentiation GO:0010830 62 0.440
Mouse
epithelial tube morphogenesis GO:0060562 303 0.427
Mouse
muscle cell development GO:0055001 133 0.422
Mouse
embryonic epithelial tube formation GO:0001838 130 0.411
Mouse
sinoatrial node development GO:0003163 4 0.409
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.401
Mouse
atrioventricular bundle cell differentiation GO:0003167 1 0.388
Mouse
endodermal cell fate specification GO:0001714 4 0.373
Mouse
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.368
Mouse
regionalization GO:0003002 337 0.367
Mouse
muscle cell differentiation GO:0042692 261 0.360
Mouse
bundle of his development GO:0003166 4 0.356
Mouse
tube closure GO:0060606 91 0.355
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.354
Mouse
myotube differentiation GO:0014902 105 0.353
Mouse
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.348
Mouse
tongue muscle cell differentiation GO:0035981 2 0.346
Mouse
cell fate commitment GO:0045165 210 0.346
Mouse
central nervous system neuron differentiation GO:0021953 162 0.345
Mouse
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.345
Mouse
left right pattern formation GO:0060972 23 0.338
pulmonary valve formation GO:0003193 1 0.337
Mouse
muscle tissue morphogenesis GO:0060415 53 0.329
Mouse
venous blood vessel morphogenesis GO:0048845 7 0.322
regulation of cardiac chamber morphogenesis GO:1901219 2 0.322
Mouse
tricuspid valve development GO:0003175 3 0.321
Mouse
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.317
Mouse
muscle cell fate specification GO:0042694 1 0.311
artery development GO:0060840 53 0.298
Mouse
endocardial cushion morphogenesis GO:0003203 18 0.289
Mouse
regulation of organ morphogenesis GO:2000027 144 0.282
Mouse
myoblast proliferation GO:0051450 11 0.279
embryonic skeletal system development GO:0048706 120 0.274
Mouse
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.268
bmp signaling pathway GO:0030509 93 0.264
Mouse
somitogenesis GO:0001756 69 0.258
Mouse
cardiac muscle cell development GO:0055013 39 0.246
Mouse
skeletal muscle organ development GO:0060538 163 0.245
Mouse
regulation of cardiac chamber formation GO:1901210 1 0.242
Mouse
canonical wnt signaling pathway GO:0060070 130 0.239
Mouse
his purkinje system development GO:0003164 4 0.237
Mouse
epithelial tube formation GO:0072175 130 0.232
Mouse
kidney development GO:0001822 213 0.229
embryonic heart tube morphogenesis GO:0003143 51 0.222
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.222
Mouse
endodermal digestive tract morphogenesis GO:0061031 4 0.220
chemotaxis GO:0006935 247 0.220
Mouse
morphogenesis of a branching structure GO:0001763 203 0.219
Mouse
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.212
Mouse
telencephalon development GO:0021537 186 0.211
Mouse
striated muscle tissue development GO:0014706 293 0.207
Mouse
mesenchymal cell development GO:0014031 93 0.203
Mouse
embryonic organ morphogenesis GO:0048562 276 0.199
Mouse
atrial cardiac muscle tissue development GO:0003228 5 0.197
forebrain development GO:0030900 302 0.196
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.194
Mouse
syncytium formation GO:0006949 43 0.194
bone development GO:0060348 120 0.192
Mouse
morphogenesis of embryonic epithelium GO:0016331 159 0.191
Mouse
left lung development GO:0060459 4 0.184
axonogenesis GO:0007409 274 0.183
Mouse
muscle fiber development GO:0048747 76 0.182
skeletal muscle fiber development GO:0048741 58 0.178
embryonic appendage morphogenesis GO:0035113 126 0.175
enamel mineralization GO:0070166 7 0.173
Mouse
negative regulation of cardiac chamber formation GO:1901211 1 0.170
Mouse
negative regulation of cell development GO:0010721 169 0.169
Mouse
negative regulation of heart looping GO:1901208 1 0.169
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.166
angiogenesis GO:0001525 201 0.165
ventricular septum development GO:0003281 42 0.164
Mouse
blood vessel morphogenesis GO:0048514 285 0.161
cardiac septum morphogenesis GO:0060411 46 0.161
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.159
Mouse
diencephalon development GO:0021536 63 0.158
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.158
Mouse
cardiocyte differentiation GO:0035051 87 0.156
Mouse
positive regulation of heart growth GO:0060421 18 0.153
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.153
regulation of skeletal muscle fiber development GO:0048742 36 0.152
mesenchyme morphogenesis GO:0072132 32 0.152
Mouse
nephron morphogenesis GO:0072028 69 0.151
wnt signaling pathway GO:0016055 188 0.151
Mouse
regulation of heart looping GO:1901207 1 0.150
Mouse
somite development GO:0061053 81 0.148
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.148
Mouse
neural tube development GO:0021915 160 0.146
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.146
Mouse
embryonic hindlimb morphogenesis GO:0035116 32 0.143
Mouse
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 2 0.143
Mouse
negative regulation of muscle cell differentiation GO:0051148 33 0.139
myoblast differentiation GO:0045445 52 0.139
Mouse
lung development GO:0030324 164 0.138
regulation of binding GO:0051098 111 0.137
mesodermal cell migration GO:0008078 4 0.137
cell proliferation in hindbrain GO:0021534 10 0.136
specification of organ position GO:0010159 3 0.135
Mouse
heart growth GO:0060419 45 0.134
Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.133
mesonephric tubule morphogenesis GO:0072171 63 0.133
neural tube formation GO:0001841 108 0.132
Mouse
mesonephric epithelium development GO:0072163 94 0.131
regulation of cardiac muscle tissue growth GO:0055021 26 0.129
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.129
Mouse
outflow tract septum morphogenesis GO:0003148 11 0.129
Mouse
cartilage development GO:0051216 140 0.127
embryonic heart tube development GO:0035050 65 0.126
Mouse
pulmonary myocardium development GO:0003350 3 0.125
renal tubule development GO:0061326 87 0.125
cardiac chamber morphogenesis GO:0003206 93 0.123
Mouse
closure of optic fissure GO:0061386 2 0.122
endocardial cushion formation GO:0003272 13 0.122
Mouse
spleen development GO:0048536 39 0.122
tube formation GO:0035148 140 0.121
Mouse
cardiac ventricle development GO:0003231 83 0.119
Mouse
cardiac atrium morphogenesis GO:0003209 23 0.118
Mouse
subthalamus development GO:0021539 2 0.118
deltoid tuberosity development GO:0035993 3 0.116
determination of left right symmetry GO:0007368 80 0.115
Mouse
embryonic limb morphogenesis GO:0030326 126 0.113
positive regulation of cell development GO:0010720 237 0.109
heart morphogenesis GO:0003007 178 0.108
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.108
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.108
nephron epithelium morphogenesis GO:0072088 68 0.108
hindbrain development GO:0030902 128 0.108
Mouse
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.107
Mouse
primary neural tube formation GO:0014020 95 0.107
Mouse
forebrain regionalization GO:0021871 25 0.106
Mouse
gland development GO:0048732 330 0.105
Mouse
inflammatory response GO:0006954 244 0.104
respiratory system development GO:0060541 190 0.104
regulation of myoblast differentiation GO:0045661 29 0.103
somatic cell dna recombination GO:0016444 51 0.103
Mouse
mesenchyme development GO:0060485 152 0.103
Mouse
determination of heart left right asymmetry GO:0061371 48 0.102
Mouse
nephron tubule morphogenesis GO:0072078 68 0.100
cardiac muscle tissue development GO:0048738 130 0.100
Mouse
response to acid chemical GO:0001101 111 0.099
Mouse
left right axis specification GO:0070986 13 0.099
embryonic digit morphogenesis GO:0042733 56 0.099
Mouse
negative regulation of cellular component organization GO:0051129 194 0.099
Mouse
cardiac septum development GO:0003279 59 0.098
Mouse
regulation of organ formation GO:0003156 34 0.096
Mouse
negative regulation of cell projection organization GO:0031345 56 0.095
Mouse
limbic system development GO:0021761 72 0.094
Mouse
tongue morphogenesis GO:0043587 8 0.094
Mouse
embryonic heart tube elongation GO:0036306 1 0.094
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.093
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.093
Mouse
negative regulation of neuron projection development GO:0010977 50 0.093
Mouse
cardiac muscle cell proliferation GO:0060038 31 0.092
Mouse
development of primary sexual characteristics GO:0045137 143 0.092
mesoderm development GO:0007498 100 0.092
Mouse
cardiac atrium development GO:0003230 24 0.091
Mouse
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.091
Mouse
single organismal cell cell adhesion GO:0016337 131 0.091
Mouse
heart formation GO:0060914 16 0.090
Mouse
kidney morphogenesis GO:0060993 83 0.089
cardiac cell development GO:0055006 41 0.088
Mouse
alpha beta t cell differentiation GO:0046632 69 0.087
Mouse
regulation of cardiac muscle tissue development GO:0055024 31 0.086
Mouse
regulation of neuron projection development GO:0010975 169 0.085
Mouse
syncytium formation by plasma membrane fusion GO:0000768 42 0.085
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.084
Mouse
cardiac left ventricle morphogenesis GO:0003214 9 0.083
Mouse
positive regulation of b cell activation GO:0050871 49 0.083
Mouse
gonad development GO:0008406 141 0.083
mesenchymal cell differentiation GO:0048762 107 0.082
Mouse
outflow tract morphogenesis GO:0003151 53 0.080
Mouse
regulation of myoblast proliferation GO:2000291 8 0.080
stem cell differentiation GO:0048863 268 0.079
Mouse
ureteric bud development GO:0001657 94 0.079
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.079
cell proliferation involved in heart morphogenesis GO:0061323 15 0.078
Mouse
connective tissue development GO:0061448 179 0.078
palate development GO:0060021 76 0.078
Mouse
aorta morphogenesis GO:0035909 22 0.078
Mouse
neural tube closure GO:0001843 90 0.077
Mouse
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.077
venous blood vessel development GO:0060841 13 0.077
negative regulation of nervous system development GO:0051961 156 0.077
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.077
Mouse
striated muscle cell development GO:0055002 125 0.076
Mouse
vagus nerve morphogenesis GO:0021644 2 0.075
Mouse
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.075
Mouse
locomotory behavior GO:0007626 195 0.075
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.074
Mouse
cerebral cortex development GO:0021987 86 0.074
Mouse
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.073
Mouse
trachea cartilage morphogenesis GO:0060535 4 0.073
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.072
Mouse
fat cell differentiation GO:0045444 160 0.072
ameboidal type cell migration GO:0001667 128 0.072
Mouse
regulation of fat cell differentiation GO:0045598 81 0.071
regulation of cell motility GO:2000145 236 0.071
blood circulation GO:0008015 195 0.071
Mouse
epithelial cell proliferation GO:0050673 174 0.070
Mouse
sensory organ morphogenesis GO:0090596 242 0.070
Mouse
cell proliferation in external granule layer GO:0021924 10 0.069
somite rostral caudal axis specification GO:0032525 13 0.069
Mouse
regulation of organelle organization GO:0033043 289 0.069
endocrine system development GO:0035270 98 0.069
Mouse
intracellular receptor signaling pathway GO:0030522 74 0.068
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.068
Mouse
positive regulation of apoptotic process GO:0043065 217 0.068
regulation of neuron differentiation GO:0045664 281 0.068
Mouse
nephron development GO:0072006 109 0.067
ventricular septum morphogenesis GO:0060412 27 0.067
Mouse
single organism cell adhesion GO:0098602 156 0.067
Mouse
cell type specific apoptotic process GO:0097285 268 0.067
Mouse
regulation of dna binding GO:0051101 39 0.067
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.066
mammary gland duct morphogenesis GO:0060603 38 0.066
Mouse
mesendoderm development GO:0048382 3 0.065
mammary gland epithelium development GO:0061180 65 0.065
Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.064
Mouse
regulation of cell migration GO:0030334 219 0.064
morphogenesis of an epithelial sheet GO:0002011 27 0.064
Mouse
visceral motor neuron differentiation GO:0021524 3 0.064
Mouse
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.062
Mouse
ventricular cardiac muscle cell development GO:0055015 11 0.062
positive regulation of stem cell proliferation GO:2000648 59 0.062
Mouse
lung cell differentiation GO:0060479 30 0.062
positive regulation of protein modification process GO:0031401 299 0.062
Mouse
skin development GO:0043588 220 0.061
regulation of cell cycle GO:0051726 281 0.061
ubiquitin dependent protein catabolic process GO:0006511 129 0.061
axon guidance GO:0007411 141 0.061
Mouse
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.061
apoptotic signaling pathway GO:0097190 306 0.061
response to fibroblast growth factor GO:0071774 47 0.060
Mouse
single fertilization GO:0007338 82 0.060
Mouse
blood vessel remodeling GO:0001974 33 0.060
Mouse
neuron projection guidance GO:0097485 141 0.060
Mouse
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.059
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.059
Mouse
renal tubule morphogenesis GO:0061333 72 0.059
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.059
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.059
Mouse
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.059
Mouse
specification of organ identity GO:0010092 30 0.059
Mouse
pharynx development GO:0060465 1 0.059
Mouse
retina development in camera type eye GO:0060041 119 0.058
positive regulation of binding GO:0051099 49 0.058
cell adhesion GO:0007155 329 0.058
Mouse
cardiac cell fate determination GO:0060913 2 0.056
negative regulation of smad protein complex assembly GO:0010991 1 0.056
Mouse
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.056
striated muscle cell proliferation GO:0014855 39 0.056
Mouse
inner ear morphogenesis GO:0042472 101 0.056
Mouse
lateral inhibition GO:0046331 1 0.056
axis elongation involved in somitogenesis GO:0090245 4 0.056
positive regulation of cell activation GO:0050867 158 0.055
Mouse
branching involved in ureteric bud morphogenesis GO:0001658 56 0.055
odontogenesis GO:0042476 78 0.055
Mouse
regulation of response to wounding GO:1903034 189 0.054
cellular response to retinoic acid GO:0071300 25 0.054
Mouse
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.054
regulation of bmp signaling pathway GO:0030510 60 0.054
neural crest cell development GO:0014032 48 0.054
Mouse
mammary gland morphogenesis GO:0060443 54 0.053
Mouse
cell activation involved in immune response GO:0002263 126 0.053
Mouse
mesonephric tubule development GO:0072164 94 0.053
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.053
wound healing GO:0042060 157 0.053
myeloid cell homeostasis GO:0002262 114 0.053
peptidyl amino acid modification GO:0018193 336 0.052
digestive tract morphogenesis GO:0048546 147 0.052
Mouse
digestive tract development GO:0048565 190 0.052
Mouse
forebrain cell migration GO:0021885 58 0.052
hypothalamus development GO:0021854 16 0.052
positive regulation of cell death GO:0010942 224 0.051
modification dependent macromolecule catabolic process GO:0043632 133 0.051
dendrite development GO:0016358 115 0.051
ureteric bud morphogenesis GO:0060675 62 0.050
heart valve development GO:0003170 23 0.050
Mouse
female sex differentiation GO:0046660 84 0.050
regulation of cellular catabolic process GO:0031329 242 0.050
regulation of stem cell proliferation GO:0072091 78 0.049
Mouse
embryonic eye morphogenesis GO:0048048 29 0.049
Mouse
formation of primary germ layer GO:0001704 77 0.049
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.049
myotube cell development GO:0014904 60 0.049
positive regulation of nervous system development GO:0051962 221 0.049
bone morphogenesis GO:0060349 78 0.048
Mouse
cellular protein complex assembly GO:0043623 116 0.048
Mouse
coronary vasculature development GO:0060976 12 0.048
Mouse
neural plate morphogenesis GO:0001839 9 0.048
Mouse
isotype switching GO:0045190 36 0.047
Mouse
negative regulation of wnt signaling pathway GO:0030178 73 0.047
Mouse
placenta development GO:0001890 140 0.047
Mouse
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060827 1 0.046
Mouse
lung morphogenesis GO:0060425 50 0.046
regulation of adaptive immune response GO:0002819 90 0.046
Mouse
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.046
his purkinje system cell differentiation GO:0060932 2 0.045
Mouse
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.045
regulation of chondrocyte differentiation GO:0032330 33 0.045
determination of digestive tract left right asymmetry GO:0071907 1 0.045
midbrain development GO:0030901 35 0.045
regulation of epithelial cell proliferation GO:0050678 141 0.045
Mouse
cardiac ventricle morphogenesis GO:0003208 50 0.045
Mouse
mapk cascade GO:0000165 281 0.045
Mouse
respiratory tube development GO:0030323 167 0.044
cell aging GO:0007569 35 0.044
Mouse
dna metabolic process GO:0006259 303 0.044
Mouse
blastocyst development GO:0001824 80 0.044
Mouse
pituitary gland development GO:0021983 38 0.044
Mouse
germ cell development GO:0007281 185 0.044
myeloid cell differentiation GO:0030099 233 0.044
histone methylation GO:0016571 71 0.044
embryonic digestive tract morphogenesis GO:0048557 17 0.044
negative regulation of myoblast differentiation GO:0045662 18 0.043
heart valve morphogenesis GO:0003179 21 0.043
Mouse
immunoglobulin production GO:0002377 73 0.043
Mouse
t cell activation GO:0042110 289 0.043
Mouse
gastrulation with mouth forming second GO:0001702 29 0.043
nephric duct formation GO:0072179 4 0.043
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.043
Mouse
negative regulation of cell proliferation GO:0008285 296 0.043
regulation of b cell activation GO:0050864 81 0.043
Mouse
forebrain neuron development GO:0021884 30 0.043
cerebral cortex cell migration GO:0021795 44 0.043
embryonic forelimb morphogenesis GO:0035115 32 0.043
Mouse
negative regulation of organelle organization GO:0010639 90 0.043
odontogenesis of dentin containing tooth GO:0042475 66 0.042
Mouse
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.042
cardiac chamber development GO:0003205 108 0.042
Mouse
atrioventricular canal development GO:0036302 5 0.042
Mouse
appendage development GO:0048736 166 0.042
peripheral nervous system neuron axonogenesis GO:0048936 3 0.041
foregut morphogenesis GO:0007440 12 0.041
lymphocyte activation involved in immune response GO:0002285 93 0.041
Mouse
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.040
Mouse
regulation of angiogenesis GO:0045765 81 0.040
mesenchymal cell apoptotic process GO:0097152 14 0.040
Mouse
male anatomical structure morphogenesis GO:0090598 4 0.040
positive regulation of immune effector process GO:0002699 107 0.040
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.040
neural nucleus development GO:0048857 22 0.040
regulation of cell projection organization GO:0031344 206 0.040
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.040
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.039
atrial septum morphogenesis GO:0060413 11 0.039
Mouse
pulmonary valve development GO:0003177 5 0.039
Mouse
b cell activation GO:0042113 161 0.039
Mouse
urogenital system development GO:0001655 261 0.039
Mouse
neural crest cell differentiation GO:0014033 54 0.039
Mouse
maintenance of apical basal cell polarity GO:0035090 3 0.039
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.039
mesoderm formation GO:0001707 62 0.039
Mouse
genitalia development GO:0048806 37 0.038
cardiac right atrium morphogenesis GO:0003213 3 0.038
membrane organization GO:0061024 245 0.038
muscle system process GO:0003012 141 0.038
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.038
trunk segmentation GO:0035290 4 0.038
male sex differentiation GO:0046661 109 0.038
notch signaling pathway GO:0007219 71 0.037
protein modification by small protein conjugation GO:0032446 187 0.037
fertilization GO:0009566 127 0.037
Mouse
lymphocyte mediated immunity GO:0002449 139 0.037
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.037
ventral spinal cord interneuron differentiation GO:0021514 16 0.037
extracellular structure organization GO:0043062 148 0.037
olfactory bulb development GO:0021772 30 0.037
Mouse
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.037
regulation of neural precursor cell proliferation GO:2000177 70 0.037
nephron epithelium development GO:0072009 92 0.037
t cell activation involved in immune response GO:0002286 43 0.037
Mouse
renal vesicle induction GO:0072034 3 0.036
endocardial cushion development GO:0003197 26 0.036
Mouse
atrioventricular valve development GO:0003171 15 0.036
Mouse
regulation of cardioblast differentiation GO:0051890 3 0.036
nephron tubule formation GO:0072079 20 0.036
gastrulation GO:0007369 116 0.036
Mouse
peptidyl tyrosine modification GO:0018212 145 0.036
asymmetric neuroblast division GO:0055059 1 0.036
regulation of cellular amino acid metabolic process GO:0006521 5 0.035
regulation of mesenchymal cell proliferation GO:0010464 37 0.035
Mouse
smad protein complex assembly GO:0007183 1 0.035
Mouse
stem cell development GO:0048864 219 0.035
Mouse
iris morphogenesis GO:0061072 2 0.035
positive regulation of organ growth GO:0046622 29 0.035
Mouse
gabaergic neuron differentiation GO:0097154 11 0.035
endocardial cell differentiation GO:0060956 4 0.035
forebrain generation of neurons GO:0021872 63 0.035
Mouse
neural precursor cell proliferation GO:0061351 121 0.035
telencephalon cell migration GO:0022029 55 0.034
neuron migration GO:0001764 122 0.034
Mouse
tongue development GO:0043586 18 0.034
Mouse
negative regulation of molecular function GO:0044092 258 0.034
endodermal cell fate commitment GO:0001711 12 0.033
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 220 0.033
muscle adaptation GO:0043500 39 0.033
regulation of cytokine production GO:0001817 266 0.033
regulation of protein catabolic process GO:0042176 108 0.033
somatic diversification of immune receptors GO:0002200 53 0.032
Mouse
cardiac epithelial to mesenchymal transition GO:0060317 18 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.032
lens morphogenesis in camera type eye GO:0002089 24 0.032
regulation of heart morphogenesis GO:2000826 22 0.032
Mouse
cardiac muscle tissue growth GO:0055017 37 0.032
Mouse
regulation of cellular component size GO:0032535 121 0.032
positive regulation of protein phosphorylation GO:0001934 242 0.032
Mouse
regulation of voltage gated calcium channel activity GO:1901385 4 0.031
pancreas development GO:0031016 57 0.031
leukocyte migration GO:0050900 124 0.031
Mouse
exocrine system development GO:0035272 45 0.031
ventricular cardiac muscle tissue development GO:0003229 38 0.031
Mouse
immune effector process GO:0002252 321 0.031
Mouse
hindbrain morphogenesis GO:0021575 46 0.031
cell maturation GO:0048469 127 0.031
Mouse
neuron maturation GO:0042551 29 0.031
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.031
ossification GO:0001503 216 0.031
glycosyl compound catabolic process GO:1901658 206 0.031
macromolecule catabolic process GO:0009057 281 0.031
uterus morphogenesis GO:0061038 2 0.031
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.031
male genitalia morphogenesis GO:0048808 4 0.031
kidney mesenchyme morphogenesis GO:0072131 4 0.030
parasympathetic nervous system development GO:0048486 19 0.030
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.030
Mouse
regulation of protein complex assembly GO:0043254 83 0.030
Mouse
ribose phosphate metabolic process GO:0019693 291 0.030
regulation of vasculature development GO:1901342 88 0.030
telencephalon regionalization GO:0021978 14 0.030
Mouse
positive regulation of myoblast proliferation GO:2000288 5 0.030
kidney epithelium development GO:0072073 121 0.030
regulation of cell adhesion GO:0030155 154 0.030
Mouse
blastocyst formation GO:0001825 33 0.030
Mouse
negative regulation of embryonic development GO:0045992 22 0.030
Mouse
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.030
Mouse
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.030
axis elongation GO:0003401 30 0.029
regulation of inflammatory response GO:0050727 147 0.029
aorta development GO:0035904 23 0.029
Mouse
epithelium migration GO:0090132 63 0.029
amine metabolic process GO:0009308 45 0.029
microtubule based process GO:0007017 236 0.029
homeostasis of number of cells GO:0048872 210 0.029
positive regulation of leukocyte mediated immunity GO:0002705 70 0.029
Mouse
retinal bipolar neuron differentiation GO:0060040 5 0.029
heart valve formation GO:0003188 10 0.029
Mouse
establishment of protein localization to organelle GO:0072594 118 0.029
positive regulation of immunoglobulin production GO:0002639 28 0.028
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.028
cranial nerve morphogenesis GO:0021602 26 0.028
Mouse
regulation of cerebellar granule cell precursor proliferation GO:0021936 12 0.028
epithelial cell development GO:0002064 159 0.028
purine ribonucleotide catabolic process GO:0009154 208 0.028
endothelial cell differentiation GO:0045446 41 0.028
neural plate regionalization GO:0060897 6 0.028
Mouse
regulation of hydrolase activity GO:0051336 246 0.028
mesonephric duct morphogenesis GO:0072180 4 0.028
central nervous system neuron development GO:0021954 67 0.028
paraxial mesodermal cell fate commitment GO:0048343 2 0.028
protein processing GO:0016485 163 0.028
cellular ketone metabolic process GO:0042180 84 0.028
cellular macromolecule catabolic process GO:0044265 206 0.027
ear morphogenesis GO:0042471 118 0.027
Mouse
protein ubiquitination GO:0016567 171 0.027
regulation of protein processing GO:0070613 96 0.027
regulation of action potential GO:0098900 4 0.027

Tbx4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.254
musculoskeletal system disease DOID:17 0 0.254
connective tissue disease DOID:65 0 0.254
bone disease DOID:0080001 0 0.048
cardiovascular system disease DOID:1287 0 0.032