Mus musculus

186 known processes

Tbx5

T-box 5

Tbx5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
bundle of his development GO:0003166 4 1.000
av node cell to bundle of his cell communication GO:0086067 2 1.000
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.999
Mouse
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.998
ventricular cardiac muscle cell action potential GO:0086005 4 0.998
his purkinje system cell differentiation GO:0060932 2 0.997
Mouse
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.997
cardiac muscle cell contraction GO:0086003 7 0.997
regulation of membrane depolarization GO:0003254 11 0.996
regulation of renin secretion into blood stream GO:1900133 4 0.996
sinoatrial node cell differentiation GO:0060921 3 0.995
Mouse
regulation of action potential GO:0098900 4 0.992
heart contraction GO:0060047 93 0.992
cell communication involved in cardiac conduction GO:0086065 9 0.991
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.990
regulation of heart contraction GO:0008016 77 0.988
his purkinje system development GO:0003164 4 0.987
foramen ovale closure GO:0035922 1 0.987
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.987
Mouse
heart process GO:0003015 94 0.986
regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 5 0.983
cell communication by chemical coupling GO:0010643 2 0.982
regulation of cardiac chamber formation GO:1901210 1 0.981
Mouse
cardiac muscle cell proliferation GO:0060038 31 0.980
milk ejection GO:0060156 1 0.980
vagus nerve development GO:0021564 3 0.980
Mouse
retinal cone cell development GO:0046549 8 0.969
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.967
Mouse
striated muscle tissue development GO:0014706 293 0.965
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.965
Mouse
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.960
Mouse
atrioventricular bundle cell differentiation GO:0003167 1 0.957
Mouse
sa node cell action potential GO:0086015 4 0.955
regulation of cardiac muscle cell proliferation GO:0060043 23 0.954
regulation of cardiac muscle contraction GO:0055117 21 0.952
clara cell differentiation GO:0060486 4 0.950
vagus nerve morphogenesis GO:0021644 2 0.949
Mouse
mammary placode formation GO:0060596 4 0.948
Mouse
sensory organ morphogenesis GO:0090596 242 0.948
Zebrafish Mouse
ventricular cardiac myofibril assembly GO:0055005 3 0.943
muscle tissue development GO:0060537 308 0.943
regulation of cardiac muscle tissue development GO:0055024 31 0.940
regulation of heart growth GO:0060420 31 0.935
regulation of cardiac muscle tissue growth GO:0055021 26 0.934
embryonic organ morphogenesis GO:0048562 276 0.932
Zebrafish Mouse
regulation of blood circulation GO:1903522 93 0.931
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.920
Mouse
sinoatrial node cell development GO:0060931 3 0.919
Mouse
positive regulation of transcription via serum response element binding GO:0010735 1 0.917
cardiac conduction GO:0061337 17 0.915
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060827 1 0.906
Mouse
ventricular septum development GO:0003281 42 0.905
regulation of striated muscle contraction GO:0006942 25 0.903
circulatory system process GO:0003013 197 0.900
Mouse
blood circulation GO:0008015 195 0.892
Mouse
atrial cardiac muscle cell development GO:0055014 2 0.891
enamel mineralization GO:0070166 7 0.890
Mouse
cardiac muscle tissue development GO:0048738 130 0.883
limb development GO:0060173 166 0.877
negative regulation of cardiac chamber formation GO:1901211 1 0.876
Mouse
camera type eye development GO:0043010 266 0.869
Zebrafish Mouse
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.869
Mouse
cardiac septum development GO:0003279 59 0.865
cell differentiation involved in embryonic placenta development GO:0060706 26 0.864
Mouse
regulation of tongue muscle cell differentiation GO:2001035 2 0.863
Mouse
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.858
Mouse
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.854
embryonic digit morphogenesis GO:0042733 56 0.848
Mouse
visceral motor neuron differentiation GO:0021524 3 0.844
Mouse
regulation of muscle contraction GO:0006937 49 0.842
regulation of membrane depolarization during action potential GO:0098902 1 0.840
regulation of heart rate GO:0002027 36 0.833
eye photoreceptor cell development GO:0042462 31 0.832
positive regulation of cardioblast differentiation GO:0051891 3 0.829
Human
positive regulation of heart contraction GO:0045823 14 0.828
cardiac muscle contraction GO:0060048 32 0.822
determination of heart left right asymmetry GO:0061371 48 0.813
Zebrafish Mouse
muscle cell differentiation GO:0042692 261 0.812
regulation of cardiac muscle cell contraction GO:0086004 11 0.808
atrioventricular node cell development GO:0060928 2 0.799
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.799
Mouse
embryonic placenta development GO:0001892 98 0.792
Mouse
atrial cardiac muscle cell differentiation GO:0055011 2 0.788
retina morphogenesis in camera type eye GO:0060042 45 0.781
Zebrafish
cardiac pacemaker cell fate commitment GO:0060927 1 0.780
muscle cell fate specification GO:0042694 1 0.777
sa node cell to atrial cardiac muscle cell communication GO:0086070 5 0.774
regulation of cardiac muscle cell action potential GO:0098901 1 0.772
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.768
heart morphogenesis GO:0003007 178 0.755
membrane depolarization during sa node cell action potential GO:0086046 2 0.751
sinoatrial node development GO:0003163 4 0.750
Mouse
sodium ion transmembrane transport GO:0035725 49 0.744
cardiac pacemaker cell differentiation GO:0060920 5 0.742
Mouse
cardiac muscle cell action potential involved in contraction GO:0086002 6 0.731
neuronal action potential propagation GO:0019227 8 0.725
positive regulation of heart rate GO:0010460 10 0.717
forelimb morphogenesis GO:0035136 40 0.716
regulation of striated muscle cell differentiation GO:0051153 81 0.715
Mouse
ear morphogenesis GO:0042471 118 0.710
Mouse
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 2 0.710
Mouse
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.707
cardiac muscle tissue morphogenesis GO:0055008 44 0.699
Mouse
muscle system process GO:0003012 141 0.696
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.695
embryonic heart tube morphogenesis GO:0003143 51 0.693
Zebrafish Mouse
actin mediated cell contraction GO:0070252 15 0.691
ossification GO:0001503 216 0.683
skeletal muscle fiber development GO:0048741 58 0.682
cardiac atrium development GO:0003230 24 0.681
stem cell development GO:0048864 219 0.671
Mouse
pancreatic pp cell fate commitment GO:0003329 2 0.670
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.670
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.666
regulation of organ growth GO:0046620 61 0.662
cardiac pacemaker cell development GO:0060926 5 0.661
Mouse
ventricular septum morphogenesis GO:0060412 27 0.659
Mouse
ion transmembrane transport GO:0034220 361 0.654
sensory perception of smell GO:0007608 26 0.648
tongue muscle cell differentiation GO:0035981 2 0.641
Mouse
cardiac left ventricle morphogenesis GO:0003214 9 0.634
placenta development GO:0001890 140 0.630
Mouse
ventral spinal cord interneuron fate determination GO:0060580 1 0.628
transmembrane transport GO:0055085 412 0.619
canonical wnt signaling pathway GO:0060070 130 0.609
Mouse
cell communication by electrical coupling GO:0010644 4 0.606
regulation of ion transmembrane transport GO:0034765 119 0.600
negative regulation of cell proliferation GO:0008285 296 0.599
Human
cardiac left ventricle formation GO:0003218 1 0.599
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.599
response to muscle inactivity GO:0014870 4 0.594
cardiac ventricle development GO:0003231 83 0.594
pancreatic a cell fate commitment GO:0003326 2 0.594
neural plate morphogenesis GO:0001839 9 0.593
Mouse
regulation of muscle system process GO:0090257 80 0.590
skeletal system development GO:0001501 356 0.590
Mouse
regulation of membrane potential GO:0042391 192 0.588
pancreatic pp cell differentiation GO:0003312 2 0.580
regulation of voltage gated calcium channel activity GO:1901385 4 0.573
epithelial tube formation GO:0072175 130 0.573
Mouse
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.573
smad protein complex assembly GO:0007183 1 0.566
Mouse
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.566
septum primum development GO:0003284 4 0.565
atrioventricular node cell fate commitment GO:0060929 1 0.563
epithelial tube morphogenesis GO:0060562 303 0.558
Zebrafish Mouse
respiratory system development GO:0060541 190 0.555
purkinje myocyte differentiation GO:0003168 1 0.554
inorganic cation transmembrane transport GO:0098662 207 0.552
inorganic ion transmembrane transport GO:0098660 234 0.548
sensory perception of chemical stimulus GO:0007606 51 0.542
cardiac conduction system development GO:0003161 12 0.542
forebrain development GO:0030900 302 0.535
Mouse
gland development GO:0048732 330 0.531
Mouse
muscle cell proliferation GO:0033002 52 0.520
regulation of ion transport GO:0043269 215 0.520
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.517
muscle contraction GO:0006936 101 0.511
Mouse
dna metabolic process GO:0006259 303 0.505
Mouse
odontogenesis GO:0042476 78 0.498
Mouse
cardiac muscle cell action potential GO:0086001 11 0.495
negative regulation of cardiac muscle tissue development GO:0055026 8 0.493
Human
positive regulation of cardiac muscle tissue development GO:0055025 19 0.491
skeletal muscle organ development GO:0060538 163 0.488
Mouse
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.486
Mouse
leukocyte differentiation GO:0002521 342 0.486
Mouse
response to muscle inactivity involved in regulation of muscle adaptation GO:0014877 4 0.484
retinal cone cell differentiation GO:0042670 8 0.479
cardiac muscle tissue growth GO:0055017 37 0.477
regionalization GO:0003002 337 0.476
Mouse
aortic valve morphogenesis GO:0003180 4 0.475
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.474
Mouse
atrial ventricular junction remodeling GO:0003294 2 0.474
Zebrafish
atrial septum morphogenesis GO:0060413 11 0.471
regulation of smad protein complex assembly GO:0010990 1 0.469
Mouse
neuron migration GO:0001764 122 0.463
Mouse
cation transmembrane transport GO:0098655 266 0.460
proepicardium development GO:0003342 2 0.457
Zebrafish
cardiocyte differentiation GO:0035051 87 0.451
negative regulation of heart looping GO:1901208 1 0.448
Mouse
actin filament based movement GO:0030048 23 0.446
tricuspid valve development GO:0003175 3 0.444
Mouse
odontogenesis of dentin containing tooth GO:0042475 66 0.444
Mouse
neuron maturation GO:0042551 29 0.444
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.442
forebrain neuron fate commitment GO:0021877 13 0.441
Mouse
ameboidal type cell migration GO:0001667 128 0.436
Mouse
cardiac cell development GO:0055006 41 0.434
Mouse
regulation of cell activation GO:0050865 289 0.432
Mouse
heart growth GO:0060419 45 0.431
myotube differentiation GO:0014902 105 0.431
Mouse
pericardium development GO:0060039 16 0.430
Human Zebrafish Mouse
atrioventricular node cell differentiation GO:0060922 2 0.423
cardiac myofibril assembly GO:0055003 12 0.423
globus pallidus development GO:0021759 2 0.419
cation transport GO:0006812 399 0.417
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.415
Mouse
negative regulation of cell development GO:0010721 169 0.412
Mouse
sensory perception of light stimulus GO:0050953 54 0.404
regulation of neuron projection development GO:0010975 169 0.402
Mouse
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.399
sensory perception of mechanical stimulus GO:0050954 107 0.398
Mouse
cell cell signaling involved in cardiac conduction GO:0086019 6 0.397
eye photoreceptor cell differentiation GO:0001754 41 0.393
negative regulation of nervous system development GO:0051961 156 0.386
Mouse
atrioventricular node development GO:0003162 3 0.382
regulation of cation channel activity GO:2001257 22 0.381
embryonic appendage morphogenesis GO:0035113 126 0.380
regulation of system process GO:0044057 200 0.380
regulation of cardiac chamber morphogenesis GO:1901219 2 0.370
Mouse
striated muscle cell proliferation GO:0014855 39 0.370
regulation of neuron differentiation GO:0045664 281 0.368
Mouse
embryonic epithelial tube formation GO:0001838 130 0.362
Mouse
embryonic limb morphogenesis GO:0030326 126 0.362
regulation of adaptive immune response GO:0002819 90 0.354
Mouse
regulation of calcium ion transmembrane transport GO:1903169 20 0.353
sensory perception of sound GO:0007605 97 0.351
Mouse
response to denervation involved in regulation of muscle adaptation GO:0014894 4 0.350
embryonic heart tube elongation GO:0036306 1 0.349
Mouse
photoreceptor cell development GO:0042461 40 0.346
septum transversum development GO:0003343 2 0.345
Zebrafish
striated muscle contraction GO:0006941 45 0.345
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.345
Mouse
olfactory bulb development GO:0021772 30 0.341
Mouse
axon guidance GO:0007411 141 0.336
Mouse
central nervous system neuron differentiation GO:0021953 162 0.334
Mouse
muscle fiber development GO:0048747 76 0.333
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.330
Mouse
cardiac chamber development GO:0003205 108 0.330
regulation of muscle cell apoptotic process GO:0010660 17 0.326
membrane depolarization during action potential GO:0086010 5 0.321
retinal bipolar neuron differentiation GO:0060040 5 0.321
muscle cell development GO:0055001 133 0.318
Mouse
menarche GO:0042696 1 0.317
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.317
Mouse
negative regulation of neuron projection development GO:0010977 50 0.317
Mouse
regulation of ion homeostasis GO:2000021 64 0.314
regulation of muscle tissue development GO:1901861 97 0.307
positive regulation of striated muscle tissue development GO:0045844 31 0.306
sodium ion transport GO:0006814 73 0.304
regulation of heart rate by cardiac conduction GO:0086091 6 0.302
multicellular organismal signaling GO:0035637 91 0.299
retina development in camera type eye GO:0060041 119 0.298
Zebrafish
regulation of osteoblast differentiation GO:0045667 67 0.293
endodermal cell fate specification GO:0001714 4 0.284
Mouse
immune effector process GO:0002252 321 0.284
Mouse
sensory perception GO:0007600 245 0.281
Mouse
cell differentiation in spinal cord GO:0021515 53 0.281
Mouse
stem cell maintenance GO:0019827 130 0.278
Mouse
embryonic skeletal system development GO:0048706 120 0.277
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.276
Mouse
leukocyte mediated immunity GO:0002443 174 0.274
Mouse
mesenchyme development GO:0060485 152 0.273
camera type eye photoreceptor cell differentiation GO:0060219 15 0.273
digestive system development GO:0055123 200 0.273
Mouse
embryonic heart tube development GO:0035050 65 0.271
Zebrafish Mouse
myeloid cell homeostasis GO:0002262 114 0.264
regulation of leukocyte mediated immunity GO:0002703 104 0.260
Mouse
cardiac muscle cell development GO:0055013 39 0.260
Mouse
regulation of transmembrane transport GO:0034762 128 0.255
urogenital system development GO:0001655 261 0.252
Mouse
production of molecular mediator of immune response GO:0002440 103 0.252
Mouse
ventricular cardiac muscle cell differentiation GO:0055012 17 0.252
reflex GO:0060004 22 0.251
positive regulation of osteoblast differentiation GO:0045669 34 0.251
atrial septum development GO:0003283 12 0.251
tissue remodeling GO:0048771 102 0.251
Zebrafish Mouse
tendon formation GO:0035992 4 0.248
atrioventricular valve development GO:0003171 15 0.246
tendon cell differentiation GO:0035990 4 0.246
ventricular cardiac muscle cell development GO:0055015 11 0.244
striated muscle cell development GO:0055002 125 0.244
Mouse
endocytosis GO:0006897 168 0.240
response to organic cyclic compound GO:0014070 198 0.238
cell activation involved in immune response GO:0002263 126 0.237
Mouse
lung development GO:0030324 164 0.236
b cell activation involved in immune response GO:0002312 50 0.235
Mouse
pulmonary myocardium development GO:0003350 3 0.234
cardiac ventricle morphogenesis GO:0003208 50 0.234
pulmonary valve morphogenesis GO:0003184 5 0.228
Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.224
embryonic forelimb morphogenesis GO:0035115 32 0.222
hindlimb morphogenesis GO:0035137 42 0.220
Mouse
endocardial cushion formation GO:0003272 13 0.219
Mouse
tube formation GO:0035148 140 0.217
Mouse
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.215
Mouse
pulmonary valve formation GO:0003193 1 0.213
Mouse
membrane depolarization GO:0051899 64 0.211
somatic diversification of immunoglobulins GO:0016445 43 0.208
Mouse
skeletal system morphogenesis GO:0048705 203 0.205
Mouse
pharynx development GO:0060465 1 0.205
Mouse
organ growth GO:0035265 117 0.203
muscle tissue morphogenesis GO:0060415 53 0.201
Mouse
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.200
positive regulation of calcium ion transmembrane transporter activity GO:1901021 8 0.199
muscle cell fate commitment GO:0042693 11 0.199
Mouse
outflow tract morphogenesis GO:0003151 53 0.195
Mouse
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.195
Mouse
alpha beta t cell activation GO:0046631 91 0.193
Mouse
neural retina development GO:0003407 41 0.193
embryonic heart tube left right pattern formation GO:0060971 5 0.192
regulation of actin filament based process GO:0032970 99 0.190
trophectodermal cell differentiation GO:0001829 21 0.189
Mouse
detection of light stimulus GO:0009583 25 0.188
biomineral tissue development GO:0031214 64 0.188
Mouse
regulation of lymphocyte activation GO:0051249 240 0.187
Mouse
cerebral cortex development GO:0021987 86 0.187
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.185
Mouse
heart valve development GO:0003170 23 0.185
type ii pneumocyte differentiation GO:0060510 7 0.185
labyrinthine layer development GO:0060711 49 0.184
axon ensheathment GO:0008366 76 0.184
positive regulation of blood circulation GO:1903524 22 0.182
muscle adaptation GO:0043500 39 0.181
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 6 0.181
pituitary gland development GO:0021983 38 0.180
Mouse
lymphocyte migration GO:0072676 26 0.178
Mouse
lymphocyte mediated immunity GO:0002449 139 0.178
Mouse
epithelial cell proliferation GO:0050673 174 0.176
Mouse
regulation of myotube differentiation GO:0010830 62 0.176
Mouse
amine metabolic process GO:0009308 45 0.175
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.175
Mouse
heart formation GO:0060914 16 0.174
endocrine system development GO:0035270 98 0.174
Mouse
regulation of heart looping GO:1901207 1 0.174
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.174
Mouse
telencephalon development GO:0021537 186 0.173
Mouse
positive regulation of cell adhesion GO:0045785 80 0.172
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.172
Mouse
regulation of myoblast differentiation GO:0045661 29 0.172
regulation of homeostatic process GO:0032844 182 0.170
neuromuscular process GO:0050905 99 0.170
photoreceptor cell differentiation GO:0046530 52 0.169
response to stimulus involved in regulation of muscle adaptation GO:0014874 6 0.168
spongiotrophoblast layer development GO:0060712 15 0.166
sarcomere organization GO:0045214 24 0.164
regulation of cellular amino acid metabolic process GO:0006521 5 0.162
action potential GO:0001508 78 0.160
bone morphogenesis GO:0060349 78 0.159
Mouse
cellular response to organic cyclic compound GO:0071407 87 0.157
cellular response to camp GO:0071320 11 0.156
cell proliferation involved in heart valve development GO:2000793 2 0.156
lymphocyte differentiation GO:0030098 242 0.156
Mouse
regulation of cartilage development GO:0061035 44 0.156
axonogenesis GO:0007409 274 0.152
Mouse
plasma cell differentiation GO:0002317 3 0.152
regulation of lymphocyte mediated immunity GO:0002706 84 0.152
Mouse
negative regulation of myoblast differentiation GO:0045662 18 0.151
cell adhesion GO:0007155 329 0.150
Mouse
regulation of production of molecular mediator of immune response GO:0002700 65 0.148
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.148
Mouse
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.146
Mouse
regulation of organ morphogenesis GO:2000027 144 0.146
cardiac chamber formation GO:0003207 10 0.145
endocardial cushion development GO:0003197 26 0.142
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.141
positive regulation of b cell mediated immunity GO:0002714 26 0.140
Mouse
detection of external stimulus GO:0009581 61 0.140
positive regulation of immunoglobulin production GO:0002639 28 0.139
Mouse
t cell activation involved in immune response GO:0002286 43 0.138
Mouse
cell type specific apoptotic process GO:0097285 268 0.135
Mouse
pharyngeal system development GO:0060037 17 0.135
Mouse
wound healing GO:0042060 157 0.134
response to fibroblast growth factor GO:0071774 47 0.133
Mouse
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.132
Mouse
negative regulation of cell projection organization GO:0031345 56 0.131
Mouse
apoptotic signaling pathway GO:0097190 306 0.131
palate development GO:0060021 76 0.130
Mouse
calcium ion transport GO:0006816 159 0.130
regulation of stem cell differentiation GO:2000736 50 0.130
Human
forebrain generation of neurons GO:0021872 63 0.129
Mouse
ensheathment of neurons GO:0007272 76 0.129
regulation of ossification GO:0030278 112 0.129
potassium ion transmembrane transport GO:0071805 43 0.127
bone development GO:0060348 120 0.127
Mouse
negative regulation of muscle cell apoptotic process GO:0010656 9 0.125
specification of nephron tubule identity GO:0072081 5 0.125
cytosolic calcium ion transport GO:0060401 48 0.125
coronary artery morphogenesis GO:0060982 6 0.125
Mouse
embryonic heart tube formation GO:0003144 1 0.124
nucleobase containing small molecule metabolic process GO:0055086 352 0.124
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.124
Mouse
tooth mineralization GO:0034505 9 0.124
Mouse
positive regulation of immune effector process GO:0002699 107 0.124
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.123
myelination GO:0042552 74 0.122
response to purine containing compound GO:0014074 28 0.122
nephron morphogenesis GO:0072028 69 0.120
cardiac right ventricle formation GO:0003219 3 0.120
skeletal muscle fiber differentiation GO:0098528 5 0.120
Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.120
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.119
embryonic hindlimb morphogenesis GO:0035116 32 0.119
Mouse
blood vessel morphogenesis GO:0048514 285 0.119
Mouse
locomotory behavior GO:0007626 195 0.119
histone methylation GO:0016571 71 0.118
negative regulation of striated muscle cell apoptotic process GO:0010664 8 0.118
neural tube closure GO:0001843 90 0.118
Mouse
regulation of skeletal muscle cell differentiation GO:2001014 11 0.118
Mouse
response to inactivity GO:0014854 4 0.117
negative regulation of interleukin 2 production GO:0032703 8 0.116
response to organonitrogen compound GO:0010243 246 0.114
cardiac muscle cell fate commitment GO:0060923 6 0.113
Mouse
hemangioblast cell differentiation GO:0060217 1 0.113
telencephalon cell migration GO:0022029 55 0.112
positive regulation of muscle cell differentiation GO:0051149 39 0.112
Mouse
mesodermal cell migration GO:0008078 4 0.112
renal system process GO:0003014 48 0.111
regulation of protein localization GO:0032880 231 0.111
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.111
digestive tract development GO:0048565 190 0.111
Mouse
neural crest cell migration GO:0001755 32 0.110
Mouse
glial cell fate specification GO:0021780 5 0.110
response to acid chemical GO:0001101 111 0.110
Mouse
mammary gland duct morphogenesis GO:0060603 38 0.109
Mouse
spinal cord development GO:0021510 81 0.109
Mouse
stem cell differentiation GO:0048863 268 0.109
Human Mouse
immunoglobulin mediated immune response GO:0016064 69 0.109
Mouse
cell maturation GO:0048469 127 0.108
Mouse
response to light stimulus GO:0009416 135 0.107
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.107
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.106
regulation of mapk cascade GO:0043408 248 0.106
Mouse
atrioventricular canal development GO:0036302 5 0.106
Mouse
multicellular organismal response to stress GO:0033555 62 0.105
neural crest cell differentiation GO:0014033 54 0.105
Mouse
lens development in camera type eye GO:0002088 62 0.105
positive regulation of cation channel activity GO:2001259 8 0.104
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.104
positive regulation of keratinocyte proliferation GO:0010838 4 0.104
labyrinthine layer morphogenesis GO:0060713 21 0.103
regulation of cell projection organization GO:0031344 206 0.103
Mouse
diencephalon development GO:0021536 63 0.102
Mouse
endodermal cell fate commitment GO:0001711 12 0.102
Mouse
bmp signaling pathway GO:0030509 93 0.101
Mouse
specification of organ identity GO:0010092 30 0.101
Mouse
regulation of establishment of protein localization GO:0070201 181 0.100
bone mineralization GO:0030282 54 0.100
regulation of actin filament based movement GO:1903115 12 0.100
specification of organ position GO:0010159 3 0.100
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.100
megakaryocyte differentiation GO:0030219 26 0.100
left right pattern formation GO:0060972 23 0.100
t cell activation GO:0042110 289 0.099
Mouse
pattern specification involved in metanephros development GO:0072268 4 0.099
regulation of skeletal muscle fiber development GO:0048742 36 0.099
heart trabecula formation GO:0060347 14 0.099
regulation of myeloid cell differentiation GO:0045637 96 0.098
renal tubule morphogenesis GO:0061333 72 0.098
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.098
Mouse
cellular potassium ion transport GO:0071804 43 0.097
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.097
retinoic acid receptor signaling pathway GO:0048384 17 0.097
Mouse
heart valve formation GO:0003188 10 0.096
Zebrafish Mouse
cellular amine metabolic process GO:0044106 44 0.096
positive regulation of epithelial cell proliferation GO:0050679 68 0.096
Mouse
somatic cell dna recombination GO:0016444 51 0.096
Mouse
somatic diversification of immune receptors GO:0002200 53 0.095
Mouse
heart valve morphogenesis GO:0003179 21 0.095
fat cell differentiation GO:0045444 160 0.095
regulation of protein transport GO:0051223 163 0.095
mitral valve morphogenesis GO:0003183 4 0.094
blastocyst formation GO:0001825 33 0.094
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.093
Mouse
homeostasis of number of cells GO:0048872 210 0.093
regulation of binding GO:0051098 111 0.093
chromatin modification GO:0016568 187 0.093
somite development GO:0061053 81 0.092
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.092
biological phase GO:0044848 20 0.092
cardiac ventricle formation GO:0003211 8 0.092
smad protein signal transduction GO:0060395 21 0.092
Mouse
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.092
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.091
Mouse
positive regulation of calcium ion transport GO:0051928 27 0.090
bone remodeling GO:0046849 53 0.090
detection of stimulus GO:0051606 84 0.090
forebrain neuron differentiation GO:0021879 52 0.089
Mouse
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.089
Mouse
head morphogenesis GO:0060323 34 0.088
Mouse
epithelial to mesenchymal transition GO:0001837 47 0.087
Mouse
brainstem development GO:0003360 3 0.087
primary neural tube formation GO:0014020 95 0.086
Mouse
negative regulation of smad protein complex assembly GO:0010991 1 0.086
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.086
positive regulation of lymphocyte activation GO:0051251 140 0.085
Mouse
regulation of vasodilation GO:0042312 5 0.085
somitogenesis GO:0001756 69 0.085
Mouse
regulation of neuron maturation GO:0014041 5 0.085
Mouse
appendage morphogenesis GO:0035107 149 0.085
cardiac epithelial to mesenchymal transition GO:0060317 18 0.085
regulation of stem cell proliferation GO:0072091 78 0.084
Mouse
central nervous system morphogenesis GO:0021551 2 0.084

Tbx5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.977
cardiovascular system disease DOID:1287 0 0.977
musculoskeletal system disease DOID:17 0 0.135
connective tissue disease DOID:65 0 0.135
heart disease DOID:114 0 0.088
heart conduction disease DOID:10273 0 0.085