Mus musculus

410 known processes

Tcf7l2

transcription factor 7-like 2, T-cell specific, HMG-box

(Aliases: Tcf4,mTcf-4E,mTcf-4B,Tcf-4,TCF4B,TCF4E)

Tcf7l2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic signaling pathway GO:0097190 306 0.854
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.818
Human
regionalization GO:0003002 337 0.815
Mouse Worm
positive regulation of cell development GO:0010720 237 0.708
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.580
digestive tract development GO:0048565 190 0.569
morphogenesis of a branching structure GO:0001763 203 0.516
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.511
axon guidance GO:0007411 141 0.489
regulation of wnt signaling pathway GO:0030111 123 0.478
Human Mouse Fly
epithelial cell proliferation GO:0050673 174 0.452
cell adhesion GO:0007155 329 0.451
Mouse
embryonic organ morphogenesis GO:0048562 276 0.432
digestive tract morphogenesis GO:0048546 147 0.431
wnt signaling pathway GO:0016055 188 0.422
rhythmic process GO:0048511 174 0.419
Worm
regulation of kinase activity GO:0043549 249 0.403
myeloid cell differentiation GO:0030099 233 0.402
regulation of secretion by cell GO:1903530 249 0.394
ossification GO:0001503 216 0.393
cellular amine metabolic process GO:0044106 44 0.386
extrinsic apoptotic signaling pathway GO:0097191 126 0.379
Human
regulation of transferase activity GO:0051338 263 0.368
skeletal system development GO:0001501 356 0.365
regulation of establishment of protein localization GO:0070201 181 0.360
Human
cellular ketone metabolic process GO:0042180 84 0.355
negative regulation of cellular protein metabolic process GO:0032269 247 0.348
gland development GO:0048732 330 0.341
cellular response to dna damage stimulus GO:0006974 207 0.336
positive regulation of programmed cell death GO:0043068 218 0.334
regulation of hydrolase activity GO:0051336 246 0.332
regulation of cellular amine metabolic process GO:0033238 20 0.324
digestive system development GO:0055123 200 0.312
male gamete generation GO:0048232 285 0.306
stem cell development GO:0048864 219 0.297
myeloid leukocyte differentiation GO:0002573 119 0.295
nitrogen compound transport GO:0071705 271 0.289
regulation of protein serine threonine kinase activity GO:0071900 157 0.289
bmp signaling pathway GO:0030509 93 0.282
ear development GO:0043583 200 0.273
morphogenesis of a branching epithelium GO:0061138 193 0.271
Mouse
regulation of stress activated mapk cascade GO:0032872 69 0.270
leukocyte differentiation GO:0002521 342 0.269
Mouse
neuron projection guidance GO:0097485 141 0.260
camera type eye development GO:0043010 266 0.252
stem cell maintenance GO:0019827 130 0.250
regulation of cellular response to stress GO:0080135 159 0.246
regulation of protein kinase activity GO:0045859 232 0.245
regulation of secretion GO:0051046 274 0.240
kidney development GO:0001822 213 0.235
epithelial cell development GO:0002064 159 0.234
neural tube formation GO:0001841 108 0.232
cerebellum development GO:0021549 77 0.231
regulation of bmp signaling pathway GO:0030510 60 0.230
regulation of body fluid levels GO:0050878 162 0.229
stem cell differentiation GO:0048863 268 0.229
protein localization to nucleus GO:0034504 121 0.227
regulation of neuron differentiation GO:0045664 281 0.226
blood vessel morphogenesis GO:0048514 285 0.225
Mouse
muscle tissue development GO:0060537 308 0.223
regulation of protein localization GO:0032880 231 0.221
Human
sensory perception GO:0007600 245 0.218
Mouse
response to organonitrogen compound GO:0010243 246 0.215
urogenital system development GO:0001655 261 0.214
negative regulation of cell proliferation GO:0008285 296 0.214
forebrain development GO:0030900 302 0.206
regulation of neuron projection development GO:0010975 169 0.205
rho protein signal transduction GO:0007266 32 0.205
negative regulation of hepatocyte differentiation GO:0070367 1 0.205
regulation of nucleotide catabolic process GO:0030811 122 0.203
positive regulation of mapk cascade GO:0043410 170 0.202
neuroblast proliferation GO:0007405 49 0.201
Mouse
mapk cascade GO:0000165 281 0.201
positive regulation of protein modification process GO:0031401 299 0.201
osteoclast differentiation GO:0030316 62 0.201
skeletal system morphogenesis GO:0048705 203 0.197
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.197
Human
negative regulation of molecular function GO:0044092 258 0.196
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.194
pallium development GO:0021543 120 0.193
Mouse
homeostasis of number of cells GO:0048872 210 0.191
regulation of cytoplasmic transport GO:1903649 112 0.188
Human
regulation of map kinase activity GO:0043405 120 0.187
gliogenesis GO:0042063 141 0.187
nuclear import GO:0051170 95 0.182
stress activated mapk cascade GO:0051403 80 0.182
gonad development GO:0008406 141 0.180
Worm
positive regulation of kinase activity GO:0033674 155 0.180
ras protein signal transduction GO:0007265 77 0.175
cellular amino acid metabolic process GO:0006520 103 0.174
telencephalon development GO:0021537 186 0.170
Mouse
cell division GO:0051301 120 0.169
Mouse Worm
positive regulation of nervous system development GO:0051962 221 0.168
regulation of stem cell proliferation GO:0072091 78 0.168
Fly
positive regulation of cell migration GO:0030335 109 0.168
regulation of mapk cascade GO:0043408 248 0.167
cell maturation GO:0048469 127 0.166
positive regulation of neuron differentiation GO:0045666 141 0.166
limb development GO:0060173 166 0.166
Mouse
spermatogenesis GO:0007283 284 0.163
stem cell proliferation GO:0072089 117 0.162
Mouse Fly
fat cell differentiation GO:0045444 160 0.162
regulation of response to wounding GO:1903034 189 0.160
sensory perception of sound GO:0007605 97 0.160
epithelial tube morphogenesis GO:0060562 303 0.155
Mouse
regulation of protein import into nucleus GO:0042306 52 0.153
regulation of cell projection organization GO:0031344 206 0.153
striated muscle tissue development GO:0014706 293 0.149
cytoplasmic transport GO:0016482 234 0.146
synapse assembly GO:0007416 56 0.146
positive regulation of transferase activity GO:0051347 167 0.144
amine metabolic process GO:0009308 45 0.144
regulation of protein transport GO:0051223 163 0.143
Human
regulation of homeostatic process GO:0032844 182 0.142
negative regulation of phosphorus metabolic process GO:0010563 184 0.141
central nervous system neuron development GO:0021954 67 0.141
bone remodeling GO:0046849 53 0.140
establishment of tissue polarity GO:0007164 28 0.140
germ cell development GO:0007281 185 0.140
cell growth GO:0016049 130 0.139
ear morphogenesis GO:0042471 118 0.138
nucleocytoplasmic transport GO:0006913 139 0.135
embryonic skeletal system development GO:0048706 120 0.135
angiogenesis GO:0001525 201 0.134
Mouse
neuron projection extension GO:1990138 64 0.134
maintenance of cell number GO:0098727 3 0.133
regulation of hormone secretion GO:0046883 88 0.133
regulation of cell motility GO:2000145 236 0.133
hair cycle GO:0042633 90 0.132
sensory organ morphogenesis GO:0090596 242 0.132
protein import GO:0017038 101 0.128
regulation of cell migration GO:0030334 219 0.126
negative regulation of epithelial cell proliferation GO:0050680 64 0.126
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.126
regulation of jnk cascade GO:0046328 62 0.125
single organism nuclear import GO:1902593 95 0.125
lymphocyte differentiation GO:0030098 242 0.124
Mouse
hexose metabolic process GO:0019318 98 0.123
non canonical wnt signaling pathway GO:0035567 33 0.123
regulation of feeding behavior GO:0060259 3 0.122
regulation of intracellular protein transport GO:0033157 82 0.121
Human
neural precursor cell proliferation GO:0061351 121 0.119
Mouse
multi multicellular organism process GO:0044706 109 0.119
negative regulation of growth GO:0045926 99 0.119
cellular carbohydrate metabolic process GO:0044262 119 0.119
cerebellum vasculature development GO:0061300 1 0.119
regulation of cytokine production GO:0001817 266 0.118
protein localization to organelle GO:0033365 185 0.118
appendage development GO:0048736 166 0.118
Mouse Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.118
maintenance of location GO:0051235 89 0.118
negative regulation of protein modification process GO:0031400 163 0.117
regulation of lymphocyte proliferation GO:0050670 117 0.117
regulation of ras protein signal transduction GO:0046578 114 0.117
protein import into nucleus GO:0006606 95 0.116
small gtpase mediated signal transduction GO:0007264 97 0.115
bone development GO:0060348 120 0.114
nephron development GO:0072006 109 0.114
gastrulation GO:0007369 116 0.114
Mouse Worm
hormone secretion GO:0046879 128 0.113
regulation of neural precursor cell proliferation GO:2000177 70 0.112
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.112
commissural neuron axon guidance GO:0071679 8 0.111
peptide transport GO:0015833 133 0.111
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.110
positive regulation of jnk cascade GO:0046330 46 0.110
negative regulation of mitotic cell cycle embryonic GO:0045976 2 0.108
embryonic epithelial tube formation GO:0001838 130 0.107
negative regulation of apoptotic signaling pathway GO:2001234 104 0.106
Human
regulation of hormone levels GO:0010817 211 0.106
pole plasm assembly GO:0007315 2 0.106
negative regulation of blood pressure GO:0045776 22 0.105
negative regulation of protein metabolic process GO:0051248 282 0.105
inner ear morphogenesis GO:0042472 101 0.105
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.104
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.104
forebrain generation of neurons GO:0021872 63 0.103
Mouse
positive regulation of apoptotic process GO:0043065 217 0.103
intrinsic apoptotic signaling pathway GO:0097193 132 0.102
regulation of peptidase activity GO:0052547 96 0.102
developmental maturation GO:0021700 193 0.101
carbohydrate derivative biosynthetic process GO:1901137 183 0.101
Human
circulatory system process GO:0003013 197 0.101
skeletal muscle organ development GO:0060538 163 0.101
smooth muscle tissue development GO:0048745 22 0.100
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.100
nuclear transport GO:0051169 139 0.100
positive regulation of apoptotic signaling pathway GO:2001235 95 0.100
oxidation reduction process GO:0055114 342 0.100
negative regulation of protein phosphorylation GO:0001933 126 0.099
respiratory system development GO:0060541 190 0.098
Mouse Fly
positive regulation of fat cell differentiation GO:0045600 32 0.098
mammary gland epithelium development GO:0061180 65 0.098
central nervous system neuron differentiation GO:0021953 162 0.097
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.097
Human
progesterone secretion GO:0042701 1 0.097
synapse organization GO:0050808 125 0.097
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.096
lung development GO:0030324 164 0.095
positive regulation of stress activated mapk cascade GO:0032874 48 0.095
endocytosis GO:0006897 168 0.094
organ growth GO:0035265 117 0.094
negative regulation of wnt signaling pathway GO:0030178 73 0.093
Human
respiratory tube development GO:0030323 167 0.093
cartilage development GO:0051216 140 0.093
morphogenesis of embryonic epithelium GO:0016331 159 0.092
placenta development GO:0001890 140 0.092
Mouse
negative regulation of neuron projection development GO:0010977 50 0.091
gtp metabolic process GO:0046039 144 0.091
cellular chemical homeostasis GO:0055082 215 0.090
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.090
Human
locomotory behavior GO:0007626 195 0.090
regulation of epithelial cell proliferation GO:0050678 141 0.090
protein maturation GO:0051604 176 0.090
intracellular protein transport GO:0006886 204 0.089
response to oxidative stress GO:0006979 123 0.089
regulation of peptide secretion GO:0002791 77 0.088
response to monosaccharide GO:0034284 67 0.088
anatomical structure homeostasis GO:0060249 145 0.088
Zebrafish
axonogenesis GO:0007409 274 0.087
cellular homeostasis GO:0019725 240 0.087
positive regulation of neuron projection development GO:0010976 79 0.087
positive regulation of map kinase activity GO:0043406 84 0.087
blastocyst development GO:0001824 80 0.086
organic hydroxy compound metabolic process GO:1901615 203 0.086
neural tube closure GO:0001843 90 0.086
posttranscriptional regulation of gene expression GO:0010608 155 0.086
Worm
cell fate commitment GO:0045165 210 0.085
organic acid transport GO:0015849 101 0.085
t cell differentiation in thymus GO:0033077 77 0.085
energy derivation by oxidation of organic compounds GO:0015980 77 0.084
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.084
molting cycle GO:0042303 90 0.084
establishment of planar polarity GO:0001736 28 0.083
regulation of cellular response to growth factor stimulus GO:0090287 82 0.082
cell cell junction organization GO:0045216 72 0.082
cerebellum vasculature morphogenesis GO:0061301 1 0.082
cardiac ventricle development GO:0003231 83 0.081
limb morphogenesis GO:0035108 149 0.081
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.081
jnk cascade GO:0007254 72 0.080
cell substrate adhesion GO:0031589 130 0.080
positive regulation of protein phosphorylation GO:0001934 242 0.080
receptor mediated endocytosis GO:0006898 51 0.080
morphogenesis of a polarized epithelium GO:0001738 37 0.080
positive regulation of protein kinase activity GO:0045860 144 0.080
multicellular organismal signaling GO:0035637 91 0.079
peptidyl tyrosine phosphorylation GO:0018108 143 0.079
neuroblast differentiation GO:0014016 2 0.079
somatic stem cell maintenance GO:0035019 47 0.078
regulation of endopeptidase activity GO:0052548 89 0.078
synaptic transmission GO:0007268 329 0.078
development of primary sexual characteristics GO:0045137 143 0.078
Worm
forebrain neuron differentiation GO:0021879 52 0.077
syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 2 0.077
cell recognition GO:0008037 83 0.077
multicellular organism growth GO:0035264 161 0.077
purine nucleoside metabolic process GO:0042278 241 0.076
cell type specific apoptotic process GO:0097285 268 0.075
Human
epithelial tube formation GO:0072175 130 0.075
clara cell differentiation GO:0060486 4 0.074
protein processing GO:0016485 163 0.074
peptide secretion GO:0002790 114 0.074
establishment of planar polarity of embryonic epithelium GO:0042249 16 0.074
negative regulation of cell cycle GO:0045786 123 0.073
Human
regulation of cell adhesion GO:0030155 154 0.073
Mouse
hair follicle development GO:0001942 85 0.073
regulation of tight junction assembly GO:2000810 2 0.073
germ line stem cell division GO:0042078 2 0.073
regulation of cysteine type endopeptidase activity GO:2000116 65 0.073
regulation of muscle tissue development GO:1901861 97 0.073
peptide hormone secretion GO:0030072 109 0.072
regulation of rho protein signal transduction GO:0035023 71 0.072
protein targeting GO:0006605 143 0.071
regulation of cell activation GO:0050865 289 0.071
inner ear receptor cell differentiation GO:0060113 61 0.071
glucose metabolic process GO:0006006 92 0.071
developmental cell growth GO:0048588 84 0.071
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.071
glial cell differentiation GO:0010001 131 0.071
cellular response to lipid GO:0071396 145 0.071
metencephalon development GO:0022037 89 0.071
regulation of cell size GO:0008361 72 0.070
cytokine production GO:0001816 319 0.070
purine ribonucleoside metabolic process GO:0046128 241 0.070
branching morphogenesis of an epithelial tube GO:0048754 159 0.070
Mouse
negative regulation of cell development GO:0010721 169 0.070
establishment or maintenance of cell polarity GO:0007163 86 0.069
oocyte axis specification GO:0007309 2 0.069
t cell activation GO:0042110 289 0.069
Mouse
neuron apoptotic process GO:0051402 142 0.068
male sex differentiation GO:0046661 109 0.068
somite development GO:0061053 81 0.068
Mouse
epidermis development GO:0008544 187 0.068
humoral immune response GO:0006959 57 0.068
negative regulation of phosphate metabolic process GO:0045936 184 0.068
positive regulation of cell activation GO:0050867 158 0.068
regulation of peptide hormone secretion GO:0090276 75 0.068
regulation of systemic arterial blood pressure GO:0003073 61 0.067
regulation of apoptotic signaling pathway GO:2001233 197 0.067
Human
tube formation GO:0035148 140 0.066
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.066
Human
regulation of t cell activation GO:0050863 170 0.066
positive regulation of jun kinase activity GO:0043507 30 0.066
positive regulation of cellular catabolic process GO:0031331 148 0.066
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.066
cell junction organization GO:0034330 77 0.065
appendage morphogenesis GO:0035107 149 0.065
Mouse Fly
dendrite development GO:0016358 115 0.065
extracellular structure organization GO:0043062 148 0.065
g protein coupled receptor internalization GO:0002031 3 0.065
carboxylic acid transport GO:0046942 100 0.065
regulation of canonical wnt signaling pathway GO:0060828 82 0.065
Human
prostate gland development GO:0030850 48 0.065
membrane organization GO:0061024 245 0.064
negative regulation of cytokine production GO:0001818 84 0.064
peptidyl amino acid modification GO:0018193 336 0.064
positive regulation of cell motility GO:2000147 116 0.064
regulation of cell growth GO:0001558 91 0.064
regulation of microtubule based process GO:0032886 52 0.063
organic cyclic compound catabolic process GO:1901361 295 0.063
g protein coupled receptor signaling pathway GO:0007186 243 0.062
regulation of blood pressure GO:0008217 93 0.062
negative regulation of synapse assembly GO:0051964 3 0.062
muscle cell differentiation GO:0042692 261 0.062
mitotic cell cycle GO:0000278 195 0.062
Worm
regulation of mitotic cell cycle GO:0007346 126 0.062
positive regulation of cell death GO:0010942 224 0.061
mesonephric tubule morphogenesis GO:0072171 63 0.061
regulation of rho gtpase activity GO:0032319 58 0.061
organic anion transport GO:0015711 137 0.061
cellular amide metabolic process GO:0043603 58 0.061
chemotaxis GO:0006935 247 0.061
regulation of chemotaxis GO:0050920 53 0.060
ion transmembrane transport GO:0034220 361 0.060
regulation of cell cycle process GO:0010564 160 0.060
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.060
negative regulation of cell adhesion GO:0007162 45 0.060
organonitrogen compound biosynthetic process GO:1901566 192 0.059
female gamete generation GO:0007292 74 0.059
ribonucleotide metabolic process GO:0009259 291 0.059
erythrocyte differentiation GO:0030218 88 0.059
cation homeostasis GO:0055080 212 0.059
negative regulation of nervous system development GO:0051961 156 0.058
regulation of embryonic development GO:0045995 71 0.058
substrate adhesion dependent cell spreading GO:0034446 30 0.058
nephron morphogenesis GO:0072028 69 0.058
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.058
endothelial cell differentiation GO:0045446 41 0.058
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.058
Human
negative regulation of neuron differentiation GO:0045665 101 0.058
immune effector process GO:0002252 321 0.058
Mouse
canonical wnt signaling pathway GO:0060070 130 0.057
hindbrain morphogenesis GO:0021575 46 0.057
positive regulation of lymphocyte activation GO:0051251 140 0.057
positive regulation of hydrolase activity GO:0051345 148 0.057
response to inorganic substance GO:0010035 96 0.057
striated muscle cell development GO:0055002 125 0.057
diencephalon development GO:0021536 63 0.057
regulation of cell cycle GO:0051726 281 0.057
Human
regulation of stem cell differentiation GO:2000736 50 0.057
Human Mouse
sympathetic ganglion development GO:0061549 9 0.056
positive regulation of secretion GO:0051047 130 0.056
regulation of axon extension GO:0030516 43 0.056
regulation of intracellular transport GO:0032386 159 0.056
Human
renal sodium excretion GO:0035812 3 0.056
establishment of protein localization to organelle GO:0072594 118 0.056
connective tissue development GO:0061448 179 0.056
regulation of chorionic trophoblast cell proliferation GO:1901382 1 0.056
neuron projection extension involved in neuron projection guidance GO:1902284 14 0.056
positive regulation of cell projection organization GO:0031346 95 0.056
regulation of nucleotide metabolic process GO:0006140 169 0.055
glycoprotein metabolic process GO:0009100 116 0.055
Human
liver development GO:0001889 66 0.055
negative regulation of mitotic cell cycle GO:0045930 58 0.055
carbon catabolite activation of transcription GO:0045991 4 0.055
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.055
glucose homeostasis GO:0042593 128 0.054
segmentation GO:0035282 93 0.054
Mouse
regulation of glial cell differentiation GO:0045685 41 0.054
blood circulation GO:0008015 195 0.054
regulation of binding GO:0051098 111 0.054
Human
cellular response to molecule of bacterial origin GO:0071219 83 0.054
positive regulation of stem cell proliferation GO:2000648 59 0.054
response to peptide hormone GO:0043434 127 0.053
mechanoreceptor differentiation GO:0042490 67 0.053
lens development in camera type eye GO:0002088 62 0.053
cytosolic calcium ion homeostasis GO:0051480 70 0.053
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.053
mesoderm development GO:0007498 100 0.053
Mouse Worm
regeneration GO:0031099 38 0.053
multicellular organismal homeostasis GO:0048871 164 0.053
Zebrafish
signal transduction by p53 class mediator GO:0072331 51 0.053
sensory perception of mechanical stimulus GO:0050954 107 0.053
inner ear receptor cell development GO:0060119 39 0.052
wound healing GO:0042060 157 0.052
neuron migration GO:0001764 122 0.052
negative regulation of cellular amine metabolic process GO:0033239 1 0.052
regulation of epithelial to mesenchymal transition GO:0010717 22 0.052
Human
regulation of lymphocyte activation GO:0051249 240 0.052
muscle cell development GO:0055001 133 0.052
ureteric bud development GO:0001657 94 0.052
forebrain neuron development GO:0021884 30 0.052
regulation of leukocyte proliferation GO:0070663 121 0.052
regulation of b cell proliferation GO:0030888 39 0.052
positive regulation of glial cell proliferation GO:0060252 4 0.051
leukocyte proliferation GO:0070661 172 0.051
Mouse
regulation of fat cell differentiation GO:0045598 81 0.051
innate immune response GO:0045087 157 0.051
bone morphogenesis GO:0060349 78 0.051
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.051
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.051
somitogenesis GO:0001756 69 0.050
Mouse
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.050
epidermal growth factor receptor signaling pathway GO:0007173 28 0.050
positive regulation of chemotaxis GO:0050921 38 0.050
lipid localization GO:0010876 126 0.049
immune response activating signal transduction GO:0002757 116 0.049
regulation of t cell differentiation GO:0045580 83 0.049
nucleobase containing small molecule metabolic process GO:0055086 352 0.049
motor neuron axon guidance GO:0008045 26 0.049
cerebral cortex cell migration GO:0021795 44 0.049
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.049
regulation of protein localization to nucleus GO:1900180 60 0.048
exocrine system development GO:0035272 45 0.048
Fly
insulin secretion GO:0030073 89 0.048
response to nutrient levels GO:0031667 109 0.048
ureteric bud morphogenesis GO:0060675 62 0.048
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.048
guanosine containing compound catabolic process GO:1901069 144 0.048
neuron death GO:0070997 154 0.048
skin development GO:0043588 220 0.048
body morphogenesis GO:0010171 45 0.047
lateral inhibition GO:0046331 1 0.047
regulation of vesicle mediated transport GO:0060627 139 0.047
tissue homeostasis GO:0001894 115 0.047
Zebrafish
nucleotide biosynthetic process GO:0009165 78 0.047
negative regulation of immune system process GO:0002683 209 0.047
cellular macromolecule catabolic process GO:0044265 206 0.047
odontogenesis GO:0042476 78 0.046
neural tube patterning GO:0021532 43 0.046
kidney morphogenesis GO:0060993 83 0.046
regulation of cellular component size GO:0032535 121 0.046
development of primary female sexual characteristics GO:0046545 73 0.046
regulation of cartilage development GO:0061035 44 0.046
regulation of cellular ketone metabolic process GO:0010565 66 0.046
primary neural tube formation GO:0014020 95 0.046
pituitary gland development GO:0021983 38 0.046
myotube differentiation GO:0014902 105 0.046
signal transduction in absence of ligand GO:0038034 55 0.045
negative chemotaxis GO:0050919 14 0.045
cardiocyte differentiation GO:0035051 87 0.045
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.045
nucleoside metabolic process GO:0009116 246 0.045
lens morphogenesis in camera type eye GO:0002089 24 0.045
phosphatidylinositol mediated signaling GO:0048015 41 0.045
gtp catabolic process GO:0006184 143 0.045
single organism cell adhesion GO:0098602 156 0.045
Mouse
regulation of establishment of planar polarity GO:0090175 28 0.045
circadian regulation of gene expression GO:0032922 48 0.045
immune response regulating signaling pathway GO:0002764 125 0.045
negative regulation of cell growth GO:0030308 44 0.045
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.045
amide transport GO:0042886 138 0.044
positive regulation of cellular amine metabolic process GO:0033240 5 0.044
negative regulation of cellular component organization GO:0051129 194 0.044
myeloid cell homeostasis GO:0002262 114 0.044
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.044
regulation of synaptic plasticity GO:0048167 87 0.044
response to light stimulus GO:0009416 135 0.044
mesenchymal cell development GO:0014031 93 0.044
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.043
regulation of cell substrate adhesion GO:0010810 73 0.043
positive regulation of smooth muscle cell migration GO:0014911 4 0.043
cell activation involved in immune response GO:0002263 126 0.043
Mouse
regulation of endothelial cell migration GO:0010594 22 0.043
axis elongation involved in somitogenesis GO:0090245 4 0.043
purine ribonucleotide biosynthetic process GO:0009152 59 0.043
renal tubule morphogenesis GO:0061333 72 0.043
nephron epithelium development GO:0072009 92 0.043
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.043
regulation of actin filament based process GO:0032970 99 0.042
regulation of nucleocytoplasmic transport GO:0046822 73 0.042
Human
midgut development GO:0007494 4 0.042
cardiac chamber morphogenesis GO:0003206 93 0.042
embryonic appendage morphogenesis GO:0035113 126 0.041
Mouse

Tcf7l2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.245
disease of cellular proliferation DOID:14566 0 0.245
organ system cancer DOID:0050686 0 0.143
disease of metabolism DOID:0014667 0 0.069
Human
disease of anatomical entity DOID:7 0 0.063
musculoskeletal system disease DOID:17 0 0.063
connective tissue disease DOID:65 0 0.063
immune system cancer DOID:0060083 0 0.045
hematologic cancer DOID:2531 0 0.045
bone disease DOID:0080001 0 0.042
male reproductive organ cancer DOID:3856 0 0.041
reproductive organ cancer DOID:193 0 0.041