Mus musculus

100 known processes

Tdg

thymine DNA glycosylase

(Aliases: JZA-3,Jza1,E130317C12Rik)

Tdg biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
mrna metabolic process GO:0016071 84 0.141
microtubule cytoskeleton organization GO:0000226 157 0.126
posttranscriptional regulation of gene expression GO:0010608 155 0.122
nitrogen compound transport GO:0071705 271 0.122
nucleobase containing small molecule metabolic process GO:0055086 352 0.121
dna repair GO:0006281 107 0.118
chromatin modification GO:0016568 187 0.116
transcription coupled nucleotide excision repair GO:0006283 2 0.104
glycosyl compound metabolic process GO:1901657 246 0.100
nucleoside triphosphate metabolic process GO:0009141 230 0.098
aromatic compound catabolic process GO:0019439 286 0.092
organophosphate biosynthetic process GO:0090407 122 0.091
cellular macromolecule catabolic process GO:0044265 206 0.087
mrna splicing via spliceosome GO:0000398 43 0.086
dna dealkylation GO:0035510 11 0.084
pyrimidine containing compound metabolic process GO:0072527 11 0.083
cellular amino acid metabolic process GO:0006520 103 0.079
cytoplasmic transport GO:0016482 234 0.079
nucleoside metabolic process GO:0009116 246 0.078
mrna processing GO:0006397 63 0.077
nucleoside phosphate metabolic process GO:0006753 338 0.077
chromatin organization GO:0006325 206 0.068
pyrimidine nucleoside metabolic process GO:0006213 2 0.066
ribonucleoside metabolic process GO:0009119 245 0.065
purine nucleotide metabolic process GO:0006163 302 0.064
negative regulation of molecular function GO:0044092 258 0.064
pyrimidine ribonucleoside metabolic process GO:0046131 2 0.062
negative regulation of protein phosphorylation GO:0001933 126 0.062
cellular nitrogen compound catabolic process GO:0044270 280 0.061
chemotaxis GO:0006935 247 0.061
nucleotide biosynthetic process GO:0009165 78 0.060
ribonucleotide metabolic process GO:0009259 291 0.059
camera type eye development GO:0043010 266 0.057
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.055
mrna transport GO:0051028 13 0.054
regulation of protein kinase activity GO:0045859 232 0.053
methylation GO:0032259 134 0.052
heterocycle catabolic process GO:0046700 280 0.052
amine metabolic process GO:0009308 45 0.051
ribose phosphate metabolic process GO:0019693 291 0.051
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.051
organelle fission GO:0048285 170 0.050
ribose phosphate biosynthetic process GO:0046390 59 0.050
membrane organization GO:0061024 245 0.048
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.047
nucleoside phosphate biosynthetic process GO:1901293 79 0.047
negative regulation of phosphate metabolic process GO:0045936 184 0.044
positive regulation of protein modification process GO:0031401 299 0.044
alternative mrna splicing via spliceosome GO:0000380 12 0.044
hematopoietic progenitor cell differentiation GO:0002244 143 0.044
regionalization GO:0003002 337 0.043
myeloid cell differentiation GO:0030099 233 0.043
mitotic cell cycle process GO:1903047 159 0.042
response to radiation GO:0009314 165 0.041
organonitrogen compound biosynthetic process GO:1901566 192 0.041
nucleotide metabolic process GO:0009117 332 0.040
regulation of kinase activity GO:0043549 249 0.040
localization within membrane GO:0051668 4 0.039
rna catabolic process GO:0006401 29 0.037
covalent chromatin modification GO:0016569 163 0.036
endocytosis GO:0006897 168 0.036
regulation of protein localization GO:0032880 231 0.036
regulation of cellular amino acid metabolic process GO:0006521 5 0.035
epithelial tube morphogenesis GO:0060562 303 0.034
apoptotic signaling pathway GO:0097190 306 0.034
rna processing GO:0006396 105 0.034
macromolecule catabolic process GO:0009057 281 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
negative regulation of cellular component organization GO:0051129 194 0.033
negative regulation of protein metabolic process GO:0051248 282 0.033
development of primary sexual characteristics GO:0045137 143 0.032
cellular amine metabolic process GO:0044106 44 0.032
glycosyl compound catabolic process GO:1901658 206 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.032
ribonucleoside catabolic process GO:0042454 206 0.032
purine nucleotide catabolic process GO:0006195 211 0.032
organic cyclic compound catabolic process GO:1901361 295 0.031
response to organic cyclic compound GO:0014070 198 0.031
rna splicing via transesterification reactions GO:0000375 43 0.030
phagocytosis GO:0006909 66 0.030
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
ribonucleoside triphosphate catabolic process GO:0009203 199 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.029
wnt signaling pathway GO:0016055 188 0.028
negative regulation of protein modification process GO:0031400 163 0.028
establishment of rna localization GO:0051236 18 0.028
nucleoside catabolic process GO:0009164 206 0.028
regulation of organelle organization GO:0033043 289 0.028
sensory organ morphogenesis GO:0090596 242 0.028
positive regulation of apoptotic process GO:0043065 217 0.028
ribonucleotide catabolic process GO:0009261 208 0.028
nuclear division GO:0000280 158 0.027
ras protein signal transduction GO:0007265 77 0.027
mitotic cell cycle GO:0000278 195 0.027
negative regulation of cell proliferation GO:0008285 296 0.027
translation GO:0006412 93 0.027
cardiac muscle contraction GO:0060048 32 0.026
retina development in camera type eye GO:0060041 119 0.026
alpha amino acid metabolic process GO:1901605 59 0.026
oxidation reduction process GO:0055114 342 0.026
canonical wnt signaling pathway GO:0060070 130 0.025
blood circulation GO:0008015 195 0.025
regulation of purine nucleotide metabolic process GO:1900542 169 0.025
histone modification GO:0016570 159 0.025
ribonucleotide biosynthetic process GO:0009260 59 0.025
nucleoside phosphate catabolic process GO:1901292 222 0.025
negative regulation of phosphorylation GO:0042326 166 0.025
epithelial cell proliferation GO:0050673 174 0.025
purine ribonucleoside catabolic process GO:0046130 205 0.024
negative regulation of intracellular signal transduction GO:1902532 167 0.024
actin cytoskeleton organization GO:0030036 220 0.024
regulation of nucleotide catabolic process GO:0030811 122 0.024
small gtpase mediated signal transduction GO:0007264 97 0.024
neural precursor cell proliferation GO:0061351 121 0.024
rna splicing GO:0008380 54 0.023
regulation of cell cycle GO:0051726 281 0.023
nucleic acid transport GO:0050657 18 0.023
regulation of intracellular protein transport GO:0033157 82 0.023
spermatogenesis GO:0007283 284 0.023
purine ribonucleoside metabolic process GO:0046128 241 0.023
regulation of mapk cascade GO:0043408 248 0.023
myeloid leukocyte differentiation GO:0002573 119 0.023
demethylation GO:0070988 23 0.023
regulation of epithelial cell proliferation GO:0050678 141 0.023
organophosphate catabolic process GO:0046434 232 0.023
nucleus organization GO:0006997 45 0.023
respiratory system development GO:0060541 190 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
regulation of purine nucleotide catabolic process GO:0033121 122 0.022
regulation of apoptotic signaling pathway GO:2001233 197 0.021
protein alkylation GO:0008213 81 0.021
purine containing compound metabolic process GO:0072521 311 0.021
organonitrogen compound catabolic process GO:1901565 264 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
regulation of mrna stability GO:0043488 23 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
intracellular protein transport GO:0006886 204 0.021
purine nucleoside catabolic process GO:0006152 205 0.021
purine containing compound catabolic process GO:0072523 213 0.021
t cell activation GO:0042110 289 0.021
multicellular organismal signaling GO:0035637 91 0.020
neuronal action potential GO:0019228 54 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
cellular biogenic amine metabolic process GO:0006576 28 0.020
positive regulation of rna splicing GO:0033120 12 0.020
regulation of wnt signaling pathway GO:0030111 123 0.020
regulation of cell migration GO:0030334 219 0.020
regulation of mrna metabolic process GO:1903311 43 0.020
homeostasis of number of cells GO:0048872 210 0.020
cellular response to lipid GO:0071396 145 0.020
protein targeting GO:0006605 143 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
heart contraction GO:0060047 93 0.019
mesenchymal cell differentiation GO:0048762 107 0.019
rna transport GO:0050658 18 0.019
myosin filament organization GO:0031033 3 0.019
rna localization GO:0006403 23 0.019
regulation of mrna processing GO:0050684 41 0.019
epithelium migration GO:0090132 63 0.019
oocyte construction GO:0007308 2 0.019
circulatory system process GO:0003013 197 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
male gamete generation GO:0048232 285 0.019
regulation of nucleocytoplasmic transport GO:0046822 73 0.018
mapk cascade GO:0000165 281 0.018
leukocyte differentiation GO:0002521 342 0.018
t cell proliferation GO:0042098 120 0.018
dephosphorylation GO:0016311 129 0.018
b cell activation GO:0042113 161 0.018
leukocyte proliferation GO:0070661 172 0.018
multi multicellular organism process GO:0044706 109 0.018
multicellular organismal homeostasis GO:0048871 164 0.018
cell maturation GO:0048469 127 0.018
histone h3 k36 demethylation GO:0070544 2 0.018
maternal determination of anterior posterior axis embryo GO:0008358 2 0.017
mesenchyme development GO:0060485 152 0.017
sequestering of calcium ion GO:0051208 18 0.017
lymphocyte proliferation GO:0046651 164 0.017
mesenchymal cell development GO:0014031 93 0.017
oocyte anterior posterior axis specification GO:0007314 2 0.017
peptidyl amino acid modification GO:0018193 336 0.017
cell adhesion GO:0007155 329 0.017
regulation of gtp catabolic process GO:0033124 113 0.017
stem cell differentiation GO:0048863 268 0.017
transmembrane transport GO:0055085 412 0.017
gene silencing GO:0016458 38 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
regulation of cell projection organization GO:0031344 206 0.017
regulation of nucleotide metabolic process GO:0006140 169 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
gtp metabolic process GO:0046039 144 0.017
regulation of intracellular transport GO:0032386 159 0.017
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
inflammatory response GO:0006954 244 0.016
locomotory behavior GO:0007626 195 0.016
regulation of transferase activity GO:0051338 263 0.016
cellular protein complex assembly GO:0043623 116 0.016
gonad development GO:0008406 141 0.016
ossification GO:0001503 216 0.016
nuclear export GO:0051168 34 0.016
peptidyl lysine modification GO:0018205 77 0.016
lipid biosynthetic process GO:0008610 179 0.016
negative regulation of apoptotic signaling pathway GO:2001234 104 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
cellular ketone metabolic process GO:0042180 84 0.016
mrna export from nucleus GO:0006406 11 0.016
positive regulation of cell death GO:0010942 224 0.016
regulation of chromatin modification GO:1903308 57 0.016
transmission of nerve impulse GO:0019226 76 0.016
response to acid chemical GO:0001101 111 0.015
skeletal system morphogenesis GO:0048705 203 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.015
rhythmic process GO:0048511 174 0.015
regulation of hydrolase activity GO:0051336 246 0.015
positive regulation of mrna processing GO:0050685 16 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.015
small molecule biosynthetic process GO:0044283 132 0.015
muscle contraction GO:0006936 101 0.015
stem cell development GO:0048864 219 0.015
response to light stimulus GO:0009416 135 0.015
positive regulation of kinase activity GO:0033674 155 0.015
negative regulation of cell activation GO:0050866 111 0.015
neuron death GO:0070997 154 0.015
response to extracellular stimulus GO:0009991 127 0.015
response to lipopolysaccharide GO:0032496 128 0.015
regulation of hormone levels GO:0010817 211 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.014
meiotic cell cycle GO:0051321 122 0.014
spermatid differentiation GO:0048515 115 0.014
branching morphogenesis of an epithelial tube GO:0048754 159 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
purine ribonucleotide metabolic process GO:0009150 290 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
genitalia development GO:0048806 37 0.014
ribosomal small subunit biogenesis GO:0042274 4 0.014
cellular homeostasis GO:0019725 240 0.014
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.014
vesicle organization GO:0016050 60 0.014
pole plasm assembly GO:0007315 2 0.014
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.014
connective tissue development GO:0061448 179 0.014
compound eye development GO:0048749 1 0.014
receptor mediated endocytosis GO:0006898 51 0.014
lipoprotein metabolic process GO:0042157 43 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.014
action potential GO:0001508 78 0.014
placenta development GO:0001890 140 0.014
lipid transport GO:0006869 98 0.014
regulation of protein binding GO:0043393 60 0.014
heart process GO:0003015 94 0.014
regulation of rna stability GO:0043487 26 0.013
epithelial to mesenchymal transition GO:0001837 47 0.013
neuron projection guidance GO:0097485 141 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
negative regulation of mrna processing GO:0050686 12 0.013
response to nutrient levels GO:0031667 109 0.013
regulation of cell motility GO:2000145 236 0.013
cell type specific apoptotic process GO:0097285 268 0.013
regulation of canonical wnt signaling pathway GO:0060828 82 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
microtubule based process GO:0007017 236 0.013
glycerolipid biosynthetic process GO:0045017 50 0.013
response to organonitrogen compound GO:0010243 246 0.013
i kappab kinase nf kappab signaling GO:0007249 85 0.013
stem cell proliferation GO:0072089 117 0.013
sensory perception GO:0007600 245 0.013
sulfur compound metabolic process GO:0006790 100 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
regulation of cell activation GO:0050865 289 0.013
protein import into nucleus GO:0006606 95 0.013
morphogenesis of a branching epithelium GO:0061138 193 0.013
cellular response to organonitrogen compound GO:0071417 145 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
circadian rhythm GO:0007623 114 0.012
muscle system process GO:0003012 141 0.012
tissue homeostasis GO:0001894 115 0.012
cation transport GO:0006812 399 0.012
divalent metal ion transport GO:0070838 172 0.012
blood vessel morphogenesis GO:0048514 285 0.012
ion transmembrane transport GO:0034220 361 0.012
respiratory tube development GO:0030323 167 0.012
multicellular organism growth GO:0035264 161 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
macromolecule methylation GO:0043414 120 0.012
digestive system development GO:0055123 200 0.012
regulation of secretion GO:0051046 274 0.012
maintenance of location GO:0051235 89 0.012
negative regulation of synapse assembly GO:0051964 3 0.012
dna modification GO:0006304 50 0.012
myosin filament assembly GO:0031034 2 0.012
positive regulation of chromosome segregation GO:0051984 4 0.012
coenzyme metabolic process GO:0006732 52 0.012
protein import GO:0017038 101 0.012
cellular lipid metabolic process GO:0044255 323 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
regulation of mrna splicing via spliceosome GO:0048024 32 0.012
cellular response to acid chemical GO:0071229 68 0.012
inter male aggressive behavior GO:0002121 3 0.012
regulation of myeloid cell differentiation GO:0045637 96 0.011
regulation of chromosome organization GO:0033044 83 0.011
regulation of neuron projection development GO:0010975 169 0.011
muscle tissue morphogenesis GO:0060415 53 0.011
glucose homeostasis GO:0042593 128 0.011
regulation of binding GO:0051098 111 0.011
mature dendritic cell differentiation GO:0097029 3 0.011
regulation of cellular response to stress GO:0080135 159 0.011
circadian regulation of gene expression GO:0032922 48 0.011
cellular protein catabolic process GO:0044257 155 0.011
negative regulation of nucleotide metabolic process GO:0045980 16 0.011
pharynx development GO:0060465 1 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
response to amino acid GO:0043200 37 0.011
negative regulation of wnt signaling pathway GO:0030178 73 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
lung development GO:0030324 164 0.011
intracellular mrna localization GO:0008298 4 0.011
regulation of protein complex assembly GO:0043254 83 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
cellular chemical homeostasis GO:0055082 215 0.011
negative regulation of rna splicing GO:0033119 12 0.011
cartilage development GO:0051216 140 0.011
heart morphogenesis GO:0003007 178 0.011
nuclear import GO:0051170 95 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
response to inorganic substance GO:0010035 96 0.011
nuclear transcribed mrna catabolic process GO:0000956 16 0.011
positive regulation of dna templated transcription elongation GO:0032786 2 0.011
nuclear transport GO:0051169 139 0.011
gliogenesis GO:0042063 141 0.011
divalent inorganic cation transport GO:0072511 178 0.011
histone acetylation GO:0016573 41 0.010
positive regulation of cellular component biogenesis GO:0044089 94 0.010
regulation of organ morphogenesis GO:2000027 144 0.010
protein acylation GO:0043543 64 0.010
establishment or maintenance of cell polarity GO:0007163 86 0.010
protein modification by small protein conjugation or removal GO:0070647 207 0.010
cellular modified amino acid metabolic process GO:0006575 63 0.010
calcium ion transport GO:0006816 159 0.010
regulation of inflammatory response GO:0050727 147 0.010
cell fate commitment GO:0045165 210 0.010
mitotic nuclear division GO:0007067 48 0.010
atp catabolic process GO:0006200 55 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010

Tdg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.031
central nervous system disease DOID:331 0 0.030
neurodegenerative disease DOID:1289 0 0.025
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
large intestine cancer DOID:5672 0 0.016
colon cancer DOID:219 0 0.016
gastrointestinal system cancer DOID:3119 0 0.016
intestinal cancer DOID:10155 0 0.016
organ system cancer DOID:0050686 0 0.016
colorectal cancer DOID:9256 0 0.016
neuropathy DOID:870 0 0.013