Mus musculus

16 known processes

Tfam

transcription factor A, mitochondrial

(Aliases: Hmgts,AI661103,tsHMG,mtTFA)

Tfam biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 197 0.462
dna metabolic process GO:0006259 303 0.355
protein processing GO:0016485 163 0.233
apoptotic signaling pathway GO:0097190 306 0.209
cellular response to dna damage stimulus GO:0006974 207 0.175
protein maturation GO:0051604 176 0.162
positive regulation of cell death GO:0010942 224 0.138
cytokine production GO:0001816 319 0.136
cellular ketone metabolic process GO:0042180 84 0.125
macromolecule catabolic process GO:0009057 281 0.117
purine ribonucleotide metabolic process GO:0009150 290 0.115
mitochondrion organization GO:0007005 134 0.104
intrinsic apoptotic signaling pathway GO:0097193 132 0.102
glycosyl compound metabolic process GO:1901657 246 0.101
immune effector process GO:0002252 321 0.095
regulation of cell motility GO:2000145 236 0.094
regulation of cellular amino acid metabolic process GO:0006521 5 0.092
mitochondrial translation GO:0032543 4 0.090
protein catabolic process GO:0030163 221 0.089
cellular amino acid metabolic process GO:0006520 103 0.081
negative regulation of immune system process GO:0002683 209 0.076
cellular nitrogen compound catabolic process GO:0044270 280 0.076
purine nucleotide metabolic process GO:0006163 302 0.071
regulation of protein processing GO:0070613 96 0.070
regulation of defense response GO:0031347 233 0.070
activation of immune response GO:0002253 138 0.070
cellular macromolecule catabolic process GO:0044265 206 0.069
ribose phosphate metabolic process GO:0019693 291 0.065
peptidyl amino acid modification GO:0018193 336 0.065
heterocycle catabolic process GO:0046700 280 0.064
regulation of protein maturation GO:1903317 96 0.062
amine metabolic process GO:0009308 45 0.061
rna processing GO:0006396 105 0.061
ribonucleotide metabolic process GO:0009259 291 0.061
regulation of cellular catabolic process GO:0031329 242 0.061
purine containing compound metabolic process GO:0072521 311 0.059
stem cell differentiation GO:0048863 268 0.058
leukocyte differentiation GO:0002521 342 0.058
histone modification GO:0016570 159 0.058
positive regulation of defense response GO:0031349 124 0.057
positive regulation of innate immune response GO:0045089 80 0.057
aromatic compound catabolic process GO:0019439 286 0.057
oxidation reduction process GO:0055114 342 0.057
regulation of cell migration GO:0030334 219 0.056
multicellular organismal homeostasis GO:0048871 164 0.055
nucleotide metabolic process GO:0009117 332 0.054
striated muscle tissue development GO:0014706 293 0.054
response to oxidative stress GO:0006979 123 0.052
nucleoside metabolic process GO:0009116 246 0.052
dna repair GO:0006281 107 0.051
cell adhesion GO:0007155 329 0.051
organic cyclic compound catabolic process GO:1901361 295 0.051
response to organonitrogen compound GO:0010243 246 0.051
cellular amine metabolic process GO:0044106 44 0.051
cell type specific apoptotic process GO:0097285 268 0.051
gonad development GO:0008406 141 0.050
response to organic cyclic compound GO:0014070 198 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.049
generation of precursor metabolites and energy GO:0006091 103 0.048
chromatin organization GO:0006325 206 0.048
chromatin modification GO:0016568 187 0.048
neuron apoptotic process GO:0051402 142 0.047
cellular chemical homeostasis GO:0055082 215 0.047
purine nucleoside triphosphate metabolic process GO:0009144 226 0.047
stem cell development GO:0048864 219 0.047
regulation of innate immune response GO:0045088 91 0.046
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.046
cellular metal ion homeostasis GO:0006875 151 0.045
regulation of cellular amine metabolic process GO:0033238 20 0.044
positive regulation of cell development GO:0010720 237 0.044
regulation of proteolysis GO:0030162 164 0.044
negative regulation of molecular function GO:0044092 258 0.044
inflammatory response GO:0006954 244 0.044
regulation of cytokine production GO:0001817 266 0.043
purine nucleoside metabolic process GO:0042278 241 0.043
anatomical structure homeostasis GO:0060249 145 0.042
gland development GO:0048732 330 0.042
purine ribonucleoside metabolic process GO:0046128 241 0.041
multi multicellular organism process GO:0044706 109 0.040
regulation of kinase activity GO:0043549 249 0.040
muscle cell differentiation GO:0042692 261 0.040
regulation of protein kinase activity GO:0045859 232 0.040
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.040
negative regulation of phosphate metabolic process GO:0045936 184 0.039
cellular response to lipid GO:0071396 145 0.039
nucleobase containing small molecule metabolic process GO:0055086 352 0.038
positive regulation of programmed cell death GO:0043068 218 0.038
myeloid cell differentiation GO:0030099 233 0.038
regulation of chemotaxis GO:0050920 53 0.038
posttranscriptional regulation of gene expression GO:0010608 155 0.037
multicellular organism growth GO:0035264 161 0.037
leukocyte chemotaxis GO:0030595 69 0.037
cellular homeostasis GO:0019725 240 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.035
positive regulation of apoptotic process GO:0043065 217 0.035
positive regulation of cytokine production GO:0001819 174 0.034
positive regulation of cell motility GO:2000147 116 0.034
negative regulation of cellular component organization GO:0051129 194 0.034
chemotaxis GO:0006935 247 0.034
cation homeostasis GO:0055080 212 0.033
regulation of apoptotic signaling pathway GO:2001233 197 0.033
regulation of cell activation GO:0050865 289 0.033
production of molecular mediator of immune response GO:0002440 103 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.033
atp metabolic process GO:0046034 75 0.032
regulation of t cell activation GO:0050863 170 0.032
regulation of cell cycle GO:0051726 281 0.031
negative regulation of cell proliferation GO:0008285 296 0.031
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.031
regulation of leukocyte differentiation GO:1902105 159 0.030
membrane organization GO:0061024 245 0.030
ribonucleoside triphosphate metabolic process GO:0009199 220 0.030
ribonucleoside monophosphate metabolic process GO:0009161 80 0.030
cell fate commitment GO:0045165 210 0.030
translation GO:0006412 93 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.029
metal ion homeostasis GO:0055065 189 0.029
blood vessel morphogenesis GO:0048514 285 0.029
regulation of organelle organization GO:0033043 289 0.029
cellular respiration GO:0045333 38 0.029
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.028
regulation of mitotic cell cycle GO:0007346 126 0.028
regulation of inflammatory response GO:0050727 147 0.028
gliogenesis GO:0042063 141 0.028
morphogenesis of embryonic epithelium GO:0016331 159 0.028
nucleoside phosphate metabolic process GO:0006753 338 0.028
positive regulation of nervous system development GO:0051962 221 0.027
response to lipopolysaccharide GO:0032496 128 0.027
organelle assembly GO:0070925 177 0.027
regulation of lymphocyte activation GO:0051249 240 0.027
covalent chromatin modification GO:0016569 163 0.027
regulation of secretion by cell GO:1903530 249 0.027
dna catabolic process GO:0006308 19 0.026
organelle fission GO:0048285 170 0.026
defense response to virus GO:0051607 68 0.026
male gamete generation GO:0048232 285 0.026
regulation of transferase activity GO:0051338 263 0.026
epithelial cell proliferation GO:0050673 174 0.026
t cell activation GO:0042110 289 0.026
nitrogen compound transport GO:0071705 271 0.025
myeloid leukocyte differentiation GO:0002573 119 0.025
nucleoside monophosphate metabolic process GO:0009123 85 0.025
lymphocyte mediated immunity GO:0002449 139 0.025
positive regulation of protein modification process GO:0031401 299 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
digestive tract development GO:0048565 190 0.025
nucleoside triphosphate metabolic process GO:0009141 230 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
immune response regulating signaling pathway GO:0002764 125 0.024
neuron death GO:0070997 154 0.024
energy derivation by oxidation of organic compounds GO:0015980 77 0.024
digestive system development GO:0055123 200 0.024
positive regulation of cell migration GO:0030335 109 0.023
innate immune response GO:0045087 157 0.023
dna replication GO:0006260 52 0.023
cellular response to organic cyclic compound GO:0071407 87 0.023
cellular response to extracellular stimulus GO:0031668 81 0.023
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.023
regulation of cell adhesion GO:0030155 154 0.023
cellular response to growth factor stimulus GO:0071363 197 0.023
regulation of response to wounding GO:1903034 189 0.023
circulatory system process GO:0003013 197 0.023
protein targeting GO:0006605 143 0.023
skeletal muscle organ development GO:0060538 163 0.023
engulfment of apoptotic cell GO:0043652 3 0.023
cellular protein complex assembly GO:0043623 116 0.022
stem cell maintenance GO:0019827 130 0.022
regulation of multi organism process GO:0043900 111 0.022
cellular response to molecule of bacterial origin GO:0071219 83 0.022
cellular response to oxidative stress GO:0034599 76 0.022
positive regulation of proteolysis GO:0045862 85 0.022
negative regulation of dna replication GO:0008156 4 0.022
mitotic cell cycle process GO:1903047 159 0.022
ossification GO:0001503 216 0.022
positive regulation of cell activation GO:0050867 158 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
positive regulation of growth GO:0045927 104 0.022
negative regulation of apoptotic signaling pathway GO:2001234 104 0.022
negative regulation of cell cycle GO:0045786 123 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.022
lymphocyte activation involved in immune response GO:0002285 93 0.022
response to growth factor GO:0070848 198 0.021
positive regulation of apoptotic signaling pathway GO:2001235 95 0.021
regulation of body fluid levels GO:0050878 162 0.021
regulation of protein serine threonine kinase activity GO:0071900 157 0.021
response to extracellular stimulus GO:0009991 127 0.021
regulation of cellular response to stress GO:0080135 159 0.021
negative regulation of protein modification process GO:0031400 163 0.021
b cell activation GO:0042113 161 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
regulation of homeostatic process GO:0032844 182 0.020
regulation of hormone levels GO:0010817 211 0.020
regulation of secretion GO:0051046 274 0.020
response to testosterone GO:0033574 3 0.020
maintenance of location GO:0051235 89 0.020
intracellular protein transport GO:0006886 204 0.020
positive regulation of protein phosphorylation GO:0001934 242 0.020
response to endoplasmic reticulum stress GO:0034976 53 0.020
substrate adhesion dependent cell spreading GO:0034446 30 0.020
carbohydrate homeostasis GO:0033500 128 0.019
reactive oxygen species metabolic process GO:0072593 84 0.019
regulation of epithelial cell proliferation GO:0050678 141 0.019
regulation of response to biotic stimulus GO:0002831 38 0.019
skeletal system development GO:0001501 356 0.019
muscle cell development GO:0055001 133 0.019
peptidyl lysine modification GO:0018205 77 0.019
response to reactive oxygen species GO:0000302 56 0.019
action potential GO:0001508 78 0.019
developmental cell growth GO:0048588 84 0.019
positive regulation of kinase activity GO:0033674 155 0.019
methylation GO:0032259 134 0.019
cellular response to external stimulus GO:0071496 88 0.019
leukocyte mediated immunity GO:0002443 174 0.019
protein localization to organelle GO:0033365 185 0.019
ubiquitin dependent protein catabolic process GO:0006511 129 0.019
negative regulation of protein processing GO:0010955 79 0.019
locomotory behavior GO:0007626 195 0.018
negative regulation of protein metabolic process GO:0051248 282 0.018
regulation of lipid metabolic process GO:0019216 118 0.018
muscle tissue development GO:0060537 308 0.018
blood circulation GO:0008015 195 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
lymphocyte differentiation GO:0030098 242 0.018
ribonucleoside metabolic process GO:0009119 245 0.018
regulation of hydrolase activity GO:0051336 246 0.017
homeostasis of number of cells GO:0048872 210 0.017
regulation of cell cycle process GO:0010564 160 0.017
immune response activating signal transduction GO:0002757 116 0.017
protein modification by small protein conjugation or removal GO:0070647 207 0.017
antimicrobial peptide production GO:0002775 2 0.017
urogenital system development GO:0001655 261 0.017
negative regulation of protein maturation GO:1903318 79 0.017
glucose homeostasis GO:0042593 128 0.017
leukocyte activation involved in immune response GO:0002366 126 0.017
regulation of establishment of protein localization GO:0070201 181 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
cellular protein catabolic process GO:0044257 155 0.017
lipid biosynthetic process GO:0008610 179 0.017
negative regulation of hydrolase activity GO:0051346 71 0.017
forebrain development GO:0030900 302 0.017
purine containing compound catabolic process GO:0072523 213 0.017
cell growth GO:0016049 130 0.017
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.017
purine nucleoside monophosphate metabolic process GO:0009126 81 0.017
striated muscle cell development GO:0055002 125 0.017
ras protein signal transduction GO:0007265 77 0.017
intracellular receptor signaling pathway GO:0030522 74 0.017
regulation of vesicle mediated transport GO:0060627 139 0.017
response to peptide GO:1901652 136 0.017
renal system development GO:0072001 225 0.017
humoral immune response GO:0006959 57 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
negative regulation of phosphorus metabolic process GO:0010563 184 0.016
regulation of protein transport GO:0051223 163 0.016
negative regulation of cell cycle phase transition GO:1901988 48 0.016
transmembrane transport GO:0055085 412 0.016
nucleotide excision repair GO:0006289 13 0.016
regulation of mitochondrial translation GO:0070129 3 0.016
cell activation involved in immune response GO:0002263 126 0.016
endocytosis GO:0006897 168 0.016
purine ribonucleotide biosynthetic process GO:0009152 59 0.016
adaptive immune response GO:0002250 155 0.016
positive regulation of cell adhesion GO:0045785 80 0.016
innate immune response activating signal transduction GO:0002758 50 0.016
sensory perception GO:0007600 245 0.016
tissue homeostasis GO:0001894 115 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.016
protein import GO:0017038 101 0.016
myotube differentiation GO:0014902 105 0.016
meiotic cell cycle GO:0051321 122 0.016
regulation of cell cycle phase transition GO:1901987 77 0.016
small gtpase mediated signal transduction GO:0007264 97 0.016
regulation of dendritic cell chemotaxis GO:2000508 1 0.016
synaptic transmission GO:0007268 329 0.015
regulation of striated muscle cell differentiation GO:0051153 81 0.015
negative regulation of cytokine production GO:0001818 84 0.015
protein ubiquitination GO:0016567 171 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
muscle contraction GO:0006936 101 0.015
leukocyte proliferation GO:0070661 172 0.015
muscle fiber development GO:0048747 76 0.015
double strand break repair GO:0006302 48 0.015
mapk cascade GO:0000165 281 0.015
positive regulation of lymphocyte activation GO:0051251 140 0.015
interferon gamma production GO:0032609 67 0.015
neuron migration GO:0001764 122 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
regulation of protein catabolic process GO:0042176 108 0.015
positive regulation of transferase activity GO:0051347 167 0.015
regulation of neuron differentiation GO:0045664 281 0.014
regulation of translation GO:0006417 71 0.014
cytoplasmic transport GO:0016482 234 0.014
single organism cell adhesion GO:0098602 156 0.014
protein localization to membrane GO:0072657 108 0.014
rhythmic process GO:0048511 174 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.014
mitochondrial transport GO:0006839 36 0.014
regulation of membrane potential GO:0042391 192 0.014
execution phase of apoptosis GO:0097194 19 0.014
meiotic cell cycle process GO:1903046 77 0.014
negative regulation of cell cycle process GO:0010948 69 0.014
mitotic cell cycle GO:0000278 195 0.014
regulation of adaptive immune response GO:0002819 90 0.014
nucleoside catabolic process GO:0009164 206 0.014
negative regulation of immune effector process GO:0002698 55 0.014
microtubule cytoskeleton organization GO:0000226 157 0.014
negative regulation of interferon gamma production GO:0032689 18 0.014
protein acylation GO:0043543 64 0.014
chromosome segregation GO:0007059 48 0.014
cell cycle g1 s phase transition GO:0044843 57 0.014
digestive tract morphogenesis GO:0048546 147 0.013
macromolecule methylation GO:0043414 120 0.013
nuclear transport GO:0051169 139 0.013
ribonucleoprotein complex subunit organization GO:0071826 28 0.013
defense response to bacterium GO:0042742 119 0.013
cellular response to lipopolysaccharide GO:0071222 77 0.013
regulation of system process GO:0044057 200 0.013
germ cell development GO:0007281 185 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.013
divalent inorganic cation homeostasis GO:0072507 138 0.013
transmission of nerve impulse GO:0019226 76 0.013
cell chemotaxis GO:0060326 81 0.013
mrna metabolic process GO:0016071 84 0.013
heart process GO:0003015 94 0.013
pattern recognition receptor signaling pathway GO:0002221 47 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
cation transport GO:0006812 399 0.013
response to nutrient levels GO:0031667 109 0.013
immunoglobulin mediated immune response GO:0016064 69 0.013
somatic diversification of immunoglobulins GO:0016445 43 0.013
regulation of lymphocyte differentiation GO:0045619 107 0.013
mitochondrial membrane organization GO:0007006 26 0.013
cell substrate adhesion GO:0031589 130 0.013
monosaccharide metabolic process GO:0005996 106 0.013
cognition GO:0050890 149 0.013
apoptotic nuclear changes GO:0030262 9 0.013
regulation of protein localization GO:0032880 231 0.013
telencephalon development GO:0021537 186 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
negative regulation of organelle organization GO:0010639 90 0.012
positive regulation of organelle organization GO:0010638 128 0.012
response to steroid hormone GO:0048545 56 0.012
histone acetylation GO:0016573 41 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
defecation GO:0030421 1 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
proteasomal protein catabolic process GO:0010498 98 0.012
cofactor biosynthetic process GO:0051188 41 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
histone lysine methylation GO:0034968 50 0.012
immunoglobulin production GO:0002377 73 0.012
neutrophil chemotaxis GO:0030593 36 0.012
regulation of antimicrobial humoral response GO:0002759 3 0.012
regulation of peptidase activity GO:0052547 96 0.012
regulation of mitochondrion organization GO:0010821 27 0.012
phagocytosis GO:0006909 66 0.012
gastrulation GO:0007369 116 0.012
glial cell differentiation GO:0010001 131 0.012
regulation of cysteine type endopeptidase activity GO:2000116 65 0.012
apoptotic dna fragmentation GO:0006309 7 0.012
amide transport GO:0042886 138 0.011
wnt signaling pathway GO:0016055 188 0.011
protein secretion GO:0009306 111 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
male sex differentiation GO:0046661 109 0.011
divalent inorganic cation transport GO:0072511 178 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
organic hydroxy compound transport GO:0015850 93 0.011
meiotic nuclear division GO:0007126 115 0.011
regulation of myeloid cell differentiation GO:0045637 96 0.011
cellular response to peptide GO:1901653 92 0.011
dna recombination GO:0006310 92 0.011
protein import into peroxisome matrix GO:0016558 3 0.011
lateral inhibition GO:0046331 1 0.011
angiogenesis GO:0001525 201 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
positive regulation of lymphocyte proliferation GO:0050671 70 0.011
negative regulation of proteolysis GO:0045861 74 0.011
small molecule biosynthetic process GO:0044283 132 0.011
connective tissue development GO:0061448 179 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
dephosphorylation GO:0016311 129 0.011
positive regulation of behavior GO:0048520 40 0.011
somatic stem cell maintenance GO:0035019 47 0.011
response to acid chemical GO:0001101 111 0.011
regulation of protein kinase b signaling GO:0051896 56 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.010
adult locomotory behavior GO:0008344 91 0.010
ameboidal type cell migration GO:0001667 128 0.010
rig i signaling pathway GO:0039529 4 0.010
regulation of lipid biosynthetic process GO:0046890 54 0.010
regulation of steroid biosynthetic process GO:0050810 26 0.010
developmental maturation GO:0021700 193 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
nucleoside phosphate catabolic process GO:1901292 222 0.010
skeletal muscle cell differentiation GO:0035914 66 0.010
regulation of chromatin modification GO:1903308 57 0.010
regulation of mitotic cell cycle phase transition GO:1901990 73 0.010
cellular response to peptide hormone stimulus GO:0071375 92 0.010
multicellular organismal signaling GO:0035637 91 0.010
divalent metal ion transport GO:0070838 172 0.010
negative regulation of neuron apoptotic process GO:0043524 92 0.010
internal peptidyl lysine acetylation GO:0018393 42 0.010

Tfam disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.014
central nervous system disease DOID:331 0 0.012
neurodegenerative disease DOID:1289 0 0.012