Mus musculus

206 known processes

Tgfbr1

transforming growth factor, beta receptor I

(Aliases: TbetaR-I,ALK5,AU017191,TbetaRI,Alk-5)

Tgfbr1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
fused antrum stage GO:0048165 1 0.993
Mouse
regulation of lung blood pressure GO:0014916 2 0.979
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.971
Mouse
regulation of cellular senescence GO:2000772 6 0.970
Mouse
mesoderm structural organization GO:0048338 1 0.963
Mouse
regulation of tolerance induction to self antigen GO:0002649 1 0.957
Mouse
response to growth factor GO:0070848 198 0.949
positive regulation of b cell tolerance induction GO:0002663 2 0.947
Mouse
negative regulation of anti mullerian hormone signaling pathway GO:1902613 1 0.934
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.927
neuron apoptotic process GO:0051402 142 0.927
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.898
lens fiber cell apoptotic process GO:1990086 4 0.885
Mouse
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.865
Mouse
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.859
b cell tolerance induction GO:0002514 2 0.849
Mouse
response to oxidative stress GO:0006979 123 0.847
negative regulation of neuron apoptotic process GO:0043524 92 0.846
positive regulation of tolerance induction to self antigen GO:0002651 1 0.840
Mouse
mullerian duct regression GO:0001880 1 0.837
Mouse
regulation of protein kinase activity GO:0045859 232 0.833
Human Mouse
lateral mesoderm formation GO:0048370 3 0.823
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.815
positive regulation of apoptotic signaling pathway GO:2001235 95 0.813
Human Mouse
paraxial mesoderm structural organization GO:0048352 1 0.810
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.804
peptidyl serine phosphorylation GO:0018105 74 0.800
Human
positive regulation of cell activation GO:0050867 158 0.793
Mouse
positive regulation of apoptotic process GO:0043065 217 0.792
Human Mouse
respiratory tube development GO:0030323 167 0.783
Mouse Rat
response to cholesterol GO:0070723 4 0.774
positive regulation of proteolysis GO:0045862 85 0.764
myeloid cell differentiation GO:0030099 233 0.761
Mouse
t cell tolerance induction GO:0002517 6 0.743
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.742
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.735
Human Mouse
positive regulation of tolerance induction GO:0002645 8 0.733
Mouse
filopodium assembly GO:0046847 19 0.727
regulation of cell projection assembly GO:0060491 38 0.726
leukocyte differentiation GO:0002521 342 0.726
Mouse
peptidyl serine modification GO:0018209 83 0.716
Human
positive regulation of leukocyte differentiation GO:1902107 86 0.691
Mouse
response to sterol GO:0036314 4 0.689
positive regulation of t cell tolerance induction GO:0002666 6 0.664
Mouse
positive regulation of kinase activity GO:0033674 155 0.658
Human Mouse
negative regulation of vasoconstriction GO:0045906 2 0.652
Mouse
regulation of neuron apoptotic process GO:0043523 122 0.650
cell type specific apoptotic process GO:0097285 268 0.644
Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.641
regulation of kinase activity GO:0043549 249 0.641
Human Mouse
regulation of bmp signaling pathway GO:0030510 60 0.641
Mouse Fly
t cell activation GO:0042110 289 0.637
Mouse
negative regulation of neuron death GO:1901215 98 0.635
lung alveolus development GO:0048286 45 0.634
Mouse
growth plate cartilage chondrocyte development GO:0003431 3 0.626
Mouse
epidermis development GO:0008544 187 0.625
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.624
Human Mouse Fly
bmp signaling pathway GO:0030509 93 0.623
Mouse Fly
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.619
Mouse
cellular response to oxidative stress GO:0034599 76 0.611
trachea formation GO:0060440 3 0.607
Mouse
amine metabolic process GO:0009308 45 0.598
positive regulation of axon guidance GO:1902669 5 0.590
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.583
Mouse
homeostasis of number of cells GO:0048872 210 0.581
regulation of neuron death GO:1901214 134 0.575
lateral mesodermal cell fate commitment GO:0048372 2 0.572
Mouse
apoptotic signaling pathway GO:0097190 306 0.572
Human Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.572
Human Mouse Fly
bronchus morphogenesis GO:0060434 2 0.571
Mouse
regulation of neuron projection development GO:0010975 169 0.567
Mouse
placenta development GO:0001890 140 0.553
Mouse
positive regulation of protein modification process GO:0031401 299 0.547
Human Mouse Fly
tolerance induction to self antigen GO:0002513 4 0.546
Mouse
alpha beta t cell activation GO:0046631 91 0.545
Mouse
ovarian cumulus expansion GO:0001550 1 0.544
Mouse
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.541
positive regulation of lymphocyte differentiation GO:0045621 61 0.539
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.538
Mouse
response to transforming growth factor beta GO:0071559 88 0.525
negative regulation of phosphorylation GO:0042326 166 0.519
blood circulation GO:0008015 195 0.519
Mouse
pathway restricted smad protein phosphorylation GO:0060389 10 0.507
Human Fly
regulation of b cell tolerance induction GO:0002661 2 0.506
Mouse
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.503
negative regulation of cartilage development GO:0061037 17 0.494
regulation of cell size GO:0008361 72 0.488
Mouse
regulation of cellular catabolic process GO:0031329 242 0.481
Fly
t cell differentiation GO:0030217 174 0.479
Mouse
blood vessel remodeling GO:0001974 33 0.478
Mouse
neuron death GO:0070997 154 0.477
neural plate mediolateral regionalization GO:0021998 1 0.473
Mouse
purine ribonucleoside catabolic process GO:0046130 205 0.472
regulation of system process GO:0044057 200 0.471
Mouse
lymphocyte differentiation GO:0030098 242 0.471
Mouse
positive regulation of cell death GO:0010942 224 0.470
Human Mouse
female gamete generation GO:0007292 74 0.463
Mouse
peptidyl amino acid modification GO:0018193 336 0.462
Human Mouse
positive regulation of nervous system development GO:0051962 221 0.462
Mouse
response to nutrient levels GO:0031667 109 0.461
Mouse
circulatory system process GO:0003013 197 0.451
Mouse
regulation of cell projection organization GO:0031344 206 0.450
regulation of secretion by cell GO:1903530 249 0.450
Mouse
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.448
Mouse
lateral mesoderm morphogenesis GO:0048369 3 0.442
Mouse
skeletal system morphogenesis GO:0048705 203 0.441
anti mullerian hormone signaling pathway GO:1990262 1 0.440
Mouse
purine nucleotide metabolic process GO:0006163 302 0.439
regulation of cellular ketone metabolic process GO:0010565 66 0.438
positive regulation of phagocytosis engulfment GO:0060100 3 0.437
cartilage development GO:0051216 140 0.433
regulation of neuron differentiation GO:0045664 281 0.433
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.430
Human
positive regulation of hydrolase activity GO:0051345 148 0.427
regulation of cell activation GO:0050865 289 0.422
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.420
regulation of zinc ion transport GO:0071579 2 0.414
purine nucleotide catabolic process GO:0006195 211 0.412
embryonic hemopoiesis GO:0035162 23 0.411
Mouse
ribose phosphate metabolic process GO:0019693 291 0.409
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.403
Mouse
vasoconstriction GO:0042310 27 0.402
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.399
anatomical structure arrangement GO:0048532 20 0.396
Mouse
axon extension involved in axon guidance GO:0048846 14 0.395
Mouse
regulation of cellular response to stress GO:0080135 159 0.393
Mouse
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.392
negative regulation of blood circulation GO:1903523 15 0.389
Mouse
cellular response to oxygen radical GO:0071450 14 0.386
stress activated protein kinase signaling cascade GO:0031098 81 0.377
lung development GO:0030324 164 0.371
Mouse Rat
negative regulation of cell proliferation GO:0008285 296 0.369
lateral mesodermal cell differentiation GO:0048371 3 0.369
Mouse
cellular response to dna damage stimulus GO:0006974 207 0.366
erythrocyte differentiation GO:0030218 88 0.366
regulation of reactive oxygen species metabolic process GO:2000377 40 0.365
response to oxygen radical GO:0000305 16 0.361
negative regulation of immune system process GO:0002683 209 0.361
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.358
Mouse
ion transmembrane transport GO:0034220 361 0.358
positive regulation of neuron projection development GO:0010976 79 0.357
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.357
regulation of cartilage development GO:0061035 44 0.352
tolerance induction GO:0002507 14 0.349
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.348
intrinsic apoptotic signaling pathway GO:0097193 132 0.347
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.341
Mouse
response to metal ion GO:0010038 47 0.341
peptidyl threonine phosphorylation GO:0018107 31 0.340
Human Mouse
positive regulation of endothelial cell differentiation GO:0045603 7 0.340
Mouse
phenol containing compound metabolic process GO:0018958 60 0.339
positive regulation of cytokine production GO:0001819 174 0.338
regulation of blood circulation GO:1903522 93 0.337
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.336
Mouse
response to superoxide GO:0000303 16 0.331
regulation of myeloid cell differentiation GO:0045637 96 0.325
dopamine metabolic process GO:0042417 23 0.323
ribonucleoside metabolic process GO:0009119 245 0.323
hormone secretion GO:0046879 128 0.321
Mouse
lipid storage GO:0019915 36 0.320
Mouse
peptide secretion GO:0002790 114 0.319
Mouse
regulation of engulfment of apoptotic cell GO:1901074 2 0.319
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.318
Mouse
maternal placenta development GO:0001893 20 0.318
Mouse
respiratory system development GO:0060541 190 0.315
Mouse Rat
positive regulation of cell projection organization GO:0031346 95 0.314
organ growth GO:0035265 117 0.314
Mouse
paraxial mesoderm morphogenesis GO:0048340 10 0.309
Mouse
coagulation GO:0050817 78 0.306
heterocycle catabolic process GO:0046700 280 0.305
negative regulation of endothelial cell proliferation GO:0001937 8 0.305
cellular response to peptide GO:1901653 92 0.302
nucleoside phosphate metabolic process GO:0006753 338 0.297
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.297
ras protein signal transduction GO:0007265 77 0.296
skeletal system development GO:0001501 356 0.294
myeloid leukocyte activation GO:0002274 83 0.294
Mouse
negative regulation of growth GO:0045926 99 0.292
response to peptide hormone GO:0043434 127 0.292
Mouse
skin development GO:0043588 220 0.288
Mouse
nucleotide metabolic process GO:0009117 332 0.288
lymphocyte homeostasis GO:0002260 64 0.288
collagen fibril organization GO:0030199 32 0.282
activin receptor signaling pathway GO:0032924 18 0.282
Mouse Fly
actin cytoskeleton organization GO:0030036 220 0.282
ribonucleotide metabolic process GO:0009259 291 0.275
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.274
cell chemotaxis GO:0060326 81 0.274
regulation of t cell activation GO:0050863 170 0.273
Mouse
endocrine system development GO:0035270 98 0.272
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.271
regulation of t cell tolerance induction GO:0002664 6 0.269
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.268
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.267
Human Mouse Fly
synaptic transmission GO:0007268 329 0.264
response to dietary excess GO:0002021 18 0.262
Mouse
regulation of membrane potential GO:0042391 192 0.262
lung lobe morphogenesis GO:0060463 9 0.262
Mouse
nucleoside triphosphate metabolic process GO:0009141 230 0.262
endoderm development GO:0007492 45 0.261
Mouse
digestive tract development GO:0048565 190 0.256
Mouse Rat
endochondral bone growth GO:0003416 19 0.254
Mouse
regulation of blood pressure GO:0008217 93 0.254
Mouse
chondrocyte differentiation GO:0002062 72 0.253
response to monosaccharide GO:0034284 67 0.252
Mouse
response to alcohol GO:0097305 48 0.251
positive regulation of t cell activation GO:0050870 101 0.250
Mouse
positive regulation of ossification GO:0045778 47 0.249
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.249
aromatic compound catabolic process GO:0019439 286 0.249
regulation of lymphocyte activation GO:0051249 240 0.248
Mouse
mitochondrion organization GO:0007005 134 0.242
extracellular matrix organization GO:0030198 147 0.241
negative regulation of cardiac muscle cell proliferation GO:0060044 5 0.236
purine nucleoside metabolic process GO:0042278 241 0.236
development of primary female sexual characteristics GO:0046545 73 0.234
Mouse
cellular amino acid metabolic process GO:0006520 103 0.233
positive regulation of protein kinase activity GO:0045860 144 0.232
Human Mouse
actomyosin structure organization GO:0031032 56 0.232
chondrocyte development GO:0002063 24 0.230
Mouse
action potential GO:0001508 78 0.227
mesendoderm development GO:0048382 3 0.227
Mouse
purine containing compound metabolic process GO:0072521 311 0.226
nucleotide catabolic process GO:0009166 217 0.226
retina vasculature development in camera type eye GO:0061298 17 0.226
Mouse
regulation of cellular component size GO:0032535 121 0.225
Mouse
parathyroid gland development GO:0060017 5 0.224
nucleoside metabolic process GO:0009116 246 0.224
positive regulation of cellular amine metabolic process GO:0033240 5 0.224
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.221
autophagy GO:0006914 45 0.220
Fly
wound healing GO:0042060 157 0.220
antral ovarian follicle growth GO:0001547 5 0.220
Mouse
female gonad development GO:0008585 71 0.219
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.219
glycerophospholipid metabolic process GO:0006650 71 0.216
regulation of anatomical structure size GO:0090066 178 0.216
Mouse
regulation of axon guidance GO:1902667 13 0.215
Mouse
cellular amine metabolic process GO:0044106 44 0.214
regulation of alpha beta t cell differentiation GO:0046637 35 0.214
Mouse
negative regulation of organ growth GO:0046621 17 0.213
germ line stem cell division GO:0042078 2 0.213
purine nucleoside triphosphate catabolic process GO:0009146 203 0.213
organophosphate catabolic process GO:0046434 232 0.211
common partner smad protein phosphorylation GO:0007182 2 0.210
cytokine production GO:0001816 319 0.207
regulation of hormone levels GO:0010817 211 0.207
Mouse
lipid localization GO:0010876 126 0.205
Mouse
insulin secretion GO:0030073 89 0.205
Mouse
regulation of embryonic development GO:0045995 71 0.204
Mouse
axonogenesis GO:0007409 274 0.204
Mouse Fly
maintenance of location GO:0051235 89 0.202
Mouse Worm
regulation of mesoderm development GO:2000380 12 0.199
Mouse
growth plate cartilage development GO:0003417 14 0.198
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.197
negative regulation of zinc ion transmembrane transport GO:0071583 2 0.196
removal of superoxide radicals GO:0019430 12 0.193
endocardial cushion morphogenesis GO:0003203 18 0.190
Mouse
smoothened signaling pathway GO:0007224 105 0.189
Mouse
lateral mesodermal cell fate specification GO:0048377 2 0.188
Mouse
stem cell differentiation GO:0048863 268 0.188
Human Mouse
cation transport GO:0006812 399 0.186
regulation of cell migration GO:0030334 219 0.186
Mouse
cellular response to insulin stimulus GO:0032869 78 0.185
protein processing GO:0016485 163 0.185
regulation of map kinase activity GO:0043405 120 0.184
Human
leukocyte mediated immunity GO:0002443 174 0.182
purine ribonucleoside metabolic process GO:0046128 241 0.182
organic cyclic compound catabolic process GO:1901361 295 0.181
purine ribonucleotide metabolic process GO:0009150 290 0.181
regulation of cellular amine metabolic process GO:0033238 20 0.180
branching morphogenesis of an epithelial tube GO:0048754 159 0.180
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.180
regulation of hydrolase activity GO:0051336 246 0.179
positive regulation of mapk cascade GO:0043410 170 0.178
Human
ovarian follicle development GO:0001541 40 0.177
Mouse
cellular response to hormone stimulus GO:0032870 150 0.177
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.176
cell growth GO:0016049 130 0.176
Human Mouse
nucleoside monophosphate metabolic process GO:0009123 85 0.176
chemotaxis GO:0006935 247 0.174
Mouse Fly
inflammatory response GO:0006954 244 0.173
Mouse
organelle assembly GO:0070925 177 0.173
hair cycle GO:0042633 90 0.173
Mouse
sodium ion transport GO:0006814 73 0.173
glycosyl compound metabolic process GO:1901657 246 0.173
negative regulation of cellular component organization GO:0051129 194 0.173
positive regulation of protein secretion GO:0050714 52 0.172
myeloid leukocyte differentiation GO:0002573 119 0.171
Mouse
calcium ion homeostasis GO:0055074 127 0.170
response to peptide GO:1901652 136 0.170
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.169
t cell activation involved in immune response GO:0002286 43 0.168
regulation of tube size GO:0035150 57 0.168
Mouse
development of primary male sexual characteristics GO:0046546 88 0.166
regulation of cell adhesion GO:0030155 154 0.166
Worm
response to decreased oxygen levels GO:0036293 59 0.166
Rat
regulation of secretion GO:0051046 274 0.165
Mouse
oocyte construction GO:0007308 2 0.165
connective tissue development GO:0061448 179 0.165
response to organonitrogen compound GO:0010243 246 0.164
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.162
male sex differentiation GO:0046661 109 0.161
negative regulation of synaptic vesicle transport GO:1902804 3 0.158
ribonucleoside triphosphate catabolic process GO:0009203 199 0.157
gonad development GO:0008406 141 0.156
protein modification by small protein conjugation GO:0032446 187 0.154
Human
regulation of body fluid levels GO:0050878 162 0.154
regulation of nucleoside metabolic process GO:0009118 130 0.153
acute inflammatory response GO:0002526 41 0.152
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.152
Mouse
retina development in camera type eye GO:0060041 119 0.151
Mouse
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.151
vascular process in circulatory system GO:0003018 62 0.150
Mouse
response to hypoxia GO:0001666 58 0.150
Rat
regulation of lymphocyte differentiation GO:0045619 107 0.148
Mouse
blood vessel morphogenesis GO:0048514 285 0.148
cellular nitrogen compound catabolic process GO:0044270 280 0.148
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.147
definitive hemopoiesis GO:0060216 20 0.146
ribonucleotide catabolic process GO:0009261 208 0.146
inorganic ion transmembrane transport GO:0098660 234 0.145
rhythmic process GO:0048511 174 0.145
Mouse
transmembrane transport GO:0055085 412 0.144
organophosphate biosynthetic process GO:0090407 122 0.144
peptidyl threonine modification GO:0018210 31 0.143
Human Mouse
muscle cell differentiation GO:0042692 261 0.143
Mouse
cellular component assembly involved in morphogenesis GO:0010927 139 0.143
blastocyst development GO:0001824 80 0.142
cardiac muscle cell proliferation GO:0060038 31 0.142
limb development GO:0060173 166 0.141
Mouse
transition metal ion transport GO:0000041 38 0.141
regulation of neurotransmitter levels GO:0001505 87 0.140
cellular copper ion homeostasis GO:0006878 8 0.139
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.139
purine containing compound catabolic process GO:0072523 213 0.138
negative regulation of peptide secretion GO:0002792 16 0.138
Mouse
b cell differentiation GO:0030183 78 0.137
peptide transport GO:0015833 133 0.137
Mouse
membrane organization GO:0061024 245 0.137
regulation of proteolysis GO:0030162 164 0.137
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.137
cerebellum development GO:0021549 77 0.136
negative regulation of endothelial cell differentiation GO:0045602 2 0.136
Mouse Rat
muscle tissue development GO:0060537 308 0.135
regulation of vesicle mediated transport GO:0060627 139 0.135
ribonucleoside monophosphate catabolic process GO:0009158 57 0.135
erbb signaling pathway GO:0038127 32 0.134
phospholipid transport GO:0015914 21 0.134
regulation of muscle tissue development GO:1901861 97 0.131
positive regulation of cellular component biogenesis GO:0044089 94 0.131
positive regulation of alpha beta t cell activation GO:0046635 39 0.130
Mouse
oocyte axis specification GO:0007309 2 0.130
oogenesis stage GO:0022605 3 0.130
Mouse
platelet activation GO:0030168 40 0.129
regulation of leukocyte proliferation GO:0070663 121 0.128
negative regulation of peptide hormone secretion GO:0090278 16 0.128
Mouse
regulation of t cell differentiation GO:0045580 83 0.128
Mouse
leukocyte proliferation GO:0070661 172 0.127
cd4 positive alpha beta t cell activation GO:0035710 45 0.127
adaptive immune response GO:0002250 155 0.126
learning or memory GO:0007611 148 0.126
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.125
cellular response to nutrient levels GO:0031669 64 0.125
regulation of organ morphogenesis GO:2000027 144 0.124
Mouse
cellular response to lipid GO:0071396 145 0.123
female sex differentiation GO:0046660 84 0.122
Mouse
negative regulation of molecular function GO:0044092 258 0.122
ribonucleoside triphosphate metabolic process GO:0009199 220 0.121
cell aging GO:0007569 35 0.121
Mouse
renal system development GO:0072001 225 0.120
defense response to other organism GO:0098542 197 0.119
Worm
immune effector process GO:0002252 321 0.119
organic hydroxy compound metabolic process GO:1901615 203 0.119
regulation of ion transport GO:0043269 215 0.118
positive regulation of behavior GO:0048520 40 0.117
Mouse
positive regulation of transcription by galactose GO:0000411 1 0.117
cellular response to superoxide GO:0071451 14 0.117
negative regulation of secretion by cell GO:1903531 54 0.117
Mouse
nitrogen compound transport GO:0071705 271 0.116
Mouse
positive regulation of programmed cell death GO:0043068 218 0.116
Human Mouse
regulation of protein import into nucleus GO:0042306 52 0.116
Human
release of cytochrome c from mitochondria GO:0001836 23 0.116
regulation of stem cell differentiation GO:2000736 50 0.116
catecholamine metabolic process GO:0006584 30 0.115
negative regulation of protein metabolic process GO:0051248 282 0.115
bone morphogenesis GO:0060349 78 0.114
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.113
glycosyl compound catabolic process GO:1901658 206 0.112
regulation of protein serine threonine kinase activity GO:0071900 157 0.111
Human
regulation of cellular component biogenesis GO:0044087 181 0.111
neurotransmitter secretion GO:0007269 62 0.111
regionalization GO:0003002 337 0.111
ribonucleoside monophosphate metabolic process GO:0009161 80 0.111
regulation of chemotaxis GO:0050920 53 0.110
Mouse
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.110
bone development GO:0060348 120 0.109
Mouse
atp metabolic process GO:0046034 75 0.109
nk t cell differentiation GO:0001865 8 0.108
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.108
phosphatidylinositol metabolic process GO:0046488 45 0.108
regulation of hormone secretion GO:0046883 88 0.108
Mouse
appendage development GO:0048736 166 0.108
Mouse Fly
neurotransmitter transport GO:0006836 76 0.107
negative regulation of phosphorus metabolic process GO:0010563 184 0.107
cognition GO:0050890 149 0.107
lipid modification GO:0030258 65 0.107
negative regulation of bmp signaling pathway GO:0030514 35 0.107
forebrain development GO:0030900 302 0.106
Mouse
hair follicle development GO:0001942 85 0.105
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.105
Mouse
insulin receptor signaling pathway GO:0008286 49 0.105
regulation of blood vessel size GO:0050880 56 0.105
Mouse
phosphatidylinositol phosphorylation GO:0046854 23 0.105
regulation of mapk cascade GO:0043408 248 0.104
Human
negative regulation of phosphate metabolic process GO:0045936 184 0.104
regulation of oxidoreductase activity GO:0051341 15 0.104
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.103
Human Mouse
layer formation in cerebral cortex GO:0021819 13 0.103
molting cycle GO:0042303 90 0.102
Mouse
negative regulation of lymphocyte activation GO:0051250 91 0.102
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.101
regulation of ras protein signal transduction GO:0046578 114 0.101
mesodermal cell differentiation GO:0048333 22 0.101
Mouse
ovulation cycle GO:0042698 59 0.100
Mouse
regulation of smad protein import into nucleus GO:0060390 3 0.100
Human
cell activation involved in immune response GO:0002263 126 0.098
negative regulation of cellular protein metabolic process GO:0032269 247 0.098
zinc ion homeostasis GO:0055069 10 0.097
heart growth GO:0060419 45 0.097
cellular response to steroid hormone stimulus GO:0071383 33 0.097
ensheathment of neurons GO:0007272 76 0.097
wnt signaling pathway GO:0016055 188 0.096
development of primary sexual characteristics GO:0045137 143 0.095
lung lobe development GO:0060462 9 0.095
Mouse
response to organic cyclic compound GO:0014070 198 0.095
cellular lipid metabolic process GO:0044255 323 0.095
cation transmembrane transport GO:0098655 266 0.095
kidney development GO:0001822 213 0.095
endocardial cushion formation GO:0003272 13 0.094
Mouse
cellular calcium ion homeostasis GO:0006874 119 0.094
negative regulation of heart growth GO:0061117 7 0.093
organonitrogen compound biosynthetic process GO:1901566 192 0.092
compound eye development GO:0048749 1 0.092
response to extracellular stimulus GO:0009991 127 0.092
Mouse
exocytosis GO:0006887 121 0.092
negative regulation of intracellular signal transduction GO:1902532 167 0.091
cell aggregation GO:0098743 18 0.090
Mouse
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.090
epithelial cell proliferation GO:0050673 174 0.090
positive regulation of dendrite development GO:1900006 21 0.089
cellular macromolecule catabolic process GO:0044265 206 0.089
male gonad development GO:0008584 88 0.089
morphogenesis of a branching structure GO:0001763 203 0.089
Mouse
protein maturation GO:0051604 176 0.089
regulation of cell motility GO:2000145 236 0.089
Mouse
purine nucleoside monophosphate metabolic process GO:0009126 81 0.089
lipid biosynthetic process GO:0008610 179 0.088
regulation of removal of superoxide radicals GO:2000121 4 0.088
apoptotic mitochondrial changes GO:0008637 48 0.088
cation homeostasis GO:0055080 212 0.087
cellular response to organic cyclic compound GO:0071407 87 0.086
multicellular organism growth GO:0035264 161 0.086
Worm
photoreceptor cell development GO:0042461 40 0.086
cytokine production involved in immune response GO:0002367 34 0.086
stress activated mapk cascade GO:0051403 80 0.086
cellular divalent inorganic cation homeostasis GO:0072503 127 0.085
nucleobase containing small molecule metabolic process GO:0055086 352 0.085
regulation of dendritic spine development GO:0060998 22 0.085
endocardial cushion development GO:0003197 26 0.085
Mouse
response to steroid hormone GO:0048545 56 0.085
Rat
cardiac muscle tissue development GO:0048738 130 0.085
positive regulation of protein localization to nucleus GO:1900182 30 0.084
Human
regulation of chondrocyte differentiation GO:0032330 33 0.084
metal ion homeostasis GO:0055065 189 0.084
regulation of epithelial cell proliferation GO:0050678 141 0.083
peptide metabolic process GO:0006518 46 0.083
intracellular protein transport GO:0006886 204 0.083
Human
regulation of osteoblast differentiation GO:0045667 67 0.083
leukocyte chemotaxis GO:0030595 69 0.082
glycoprotein metabolic process GO:0009100 116 0.082
regulation of genetic imprinting GO:2000653 5 0.082
t helper cell differentiation GO:0042093 28 0.081
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.081
cellular ion homeostasis GO:0006873 165 0.081
cellular homeostasis GO:0019725 240 0.081
oogenesis GO:0048477 56 0.080
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.080
actin filament organization GO:0007015 113 0.080

Tgfbr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.549
disease of cellular proliferation DOID:14566 0 0.440
cancer DOID:162 0 0.294
organ system cancer DOID:0050686 0 0.294
gastrointestinal system cancer DOID:3119 0 0.123