Mus musculus

174 known processes

Thbs1

thrombospondin 1

(Aliases: tbsp1,TSP-1,TSP1,Thbs-1)

Thbs1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cell adhesion GO:0007155 329 0.966
skeletal system development GO:0001501 356 0.948
extracellular structure organization GO:0043062 148 0.948
negative regulation of cell proliferation GO:0008285 296 0.947
regulation of apoptotic signaling pathway GO:2001233 197 0.945
Human
cellular response to growth factor stimulus GO:0071363 197 0.942
regulation of proteolysis GO:0030162 164 0.926
Human
response to growth factor GO:0070848 198 0.915
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.913
negative regulation of epithelial cell proliferation GO:0050680 64 0.910
extrinsic apoptotic signaling pathway GO:0097191 126 0.906
Human
regulation of protein kinase activity GO:0045859 232 0.900
Human
response to transforming growth factor beta GO:0071559 88 0.894
lipid biosynthetic process GO:0008610 179 0.881
regulation of cell migration GO:0030334 219 0.876
regulation of cell cycle GO:0051726 281 0.863
Human
negative regulation of apoptotic signaling pathway GO:2001234 104 0.863
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.859
single organismal cell cell adhesion GO:0016337 131 0.854
connective tissue development GO:0061448 179 0.846
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.839
positive regulation of programmed cell death GO:0043068 218 0.835
Human
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.832
wound healing GO:0042060 157 0.824
Human
cell substrate adhesion GO:0031589 130 0.810
cartilage condensation GO:0001502 18 0.806
single organism cell adhesion GO:0098602 156 0.790
positive regulation of proteolysis GO:0045862 85 0.783
skeletal system morphogenesis GO:0048705 203 0.781
jnk cascade GO:0007254 72 0.775
regulation of cell adhesion GO:0030155 154 0.773
pallium development GO:0021543 120 0.763
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.762
embryonic organ morphogenesis GO:0048562 276 0.758
regulation of cellular response to growth factor stimulus GO:0090287 82 0.739
regulation of cell substrate adhesion GO:0010810 73 0.737
response to decreased oxygen levels GO:0036293 59 0.737
chemotaxis GO:0006935 247 0.730
apoptotic signaling pathway GO:0097190 306 0.726
Human
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.706
digestive tract development GO:0048565 190 0.704
regulation of transferase activity GO:0051338 263 0.689
Human
negative regulation of cell adhesion GO:0007162 45 0.668
Human
response to oxidative stress GO:0006979 123 0.668
protein catabolic process GO:0030163 221 0.662
regulation of cell motility GO:2000145 236 0.655
regulation of mapk cascade GO:0043408 248 0.650
Human
cell adhesion mediated by integrin GO:0033627 18 0.648
Fly
extracellular matrix organization GO:0030198 147 0.634
cartilage development GO:0051216 140 0.630
positive regulation of cell death GO:0010942 224 0.629
Human
regulation of epithelial cell proliferation GO:0050678 141 0.622
regulation of smad protein import into nucleus GO:0060390 3 0.622
chondrocyte differentiation GO:0002062 72 0.620
myeloid leukocyte migration GO:0097529 57 0.617
membrane lipid biosynthetic process GO:0046467 32 0.606
blood vessel morphogenesis GO:0048514 285 0.605
regulation of wnt signaling pathway GO:0030111 123 0.604
epithelial cell proliferation GO:0050673 174 0.594
ossification GO:0001503 216 0.591
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.589
regulation of peptidase activity GO:0052547 96 0.573
Human
regionalization GO:0003002 337 0.563
fatty acid metabolic process GO:0006631 121 0.562
regulation of kinase activity GO:0043549 249 0.551
Human
regulation of stress activated mapk cascade GO:0032872 69 0.549
positive regulation of cell substrate adhesion GO:0010811 47 0.545
protein maturation GO:0051604 176 0.544
Human
mesenchyme development GO:0060485 152 0.541
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.540
mapk cascade GO:0000165 281 0.527
Human
urogenital system development GO:0001655 261 0.522
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.521
cell matrix adhesion GO:0007160 68 0.514
Human
mononuclear cell migration GO:0071674 8 0.513
regulation of neuron projection development GO:0010975 169 0.511
cellular response to oxidative stress GO:0034599 76 0.511
digestive system development GO:0055123 200 0.509
ras protein signal transduction GO:0007265 77 0.503
regulation of cell cycle process GO:0010564 160 0.501
long term synaptic potentiation GO:0060291 25 0.498
response to ionizing radiation GO:0010212 42 0.497
regulation of nucleotide metabolic process GO:0006140 169 0.497
Human
sphingolipid biosynthetic process GO:0030148 26 0.494
placenta development GO:0001890 140 0.481
negative regulation of intracellular signal transduction GO:1902532 167 0.480
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.477
Human
ceramide metabolic process GO:0006672 31 0.474
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.474
macromolecule catabolic process GO:0009057 281 0.469
granulocyte migration GO:0097530 43 0.467
cellular response to inorganic substance GO:0071241 37 0.466
regulation of protein serine threonine kinase activity GO:0071900 157 0.465
Human
pole plasm assembly GO:0007315 2 0.456
muscle tissue development GO:0060537 308 0.447
response to x ray GO:0010165 11 0.446
protein localization to nucleus GO:0034504 121 0.441
regulation of jun kinase activity GO:0043506 40 0.435
positive regulation of protein phosphorylation GO:0001934 242 0.427
Human
regulation of cellular component biogenesis GO:0044087 181 0.424
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.422
multicellular organismal homeostasis GO:0048871 164 0.421
positive regulation of peptidase activity GO:0010952 49 0.419
response to reactive oxygen species GO:0000302 56 0.419
establishment of protein localization to organelle GO:0072594 118 0.407
regulation of cell growth GO:0001558 91 0.404
cell chemotaxis GO:0060326 81 0.400
mesenchymal cell differentiation GO:0048762 107 0.399
regulation of ossification GO:0030278 112 0.389
regulation of neuron differentiation GO:0045664 281 0.388
gastrulation GO:0007369 116 0.384
wound healing involved in inflammatory response GO:0002246 4 0.380
digestive tract morphogenesis GO:0048546 147 0.379
regulation of mitotic cell cycle GO:0007346 126 0.378
inflammatory response to wounding GO:0090594 4 0.376
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.371
regulation of stem cell differentiation GO:2000736 50 0.370
rho protein signal transduction GO:0007266 32 0.368
regulation of jnk cascade GO:0046328 62 0.363
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.359
negative regulation of cellular protein metabolic process GO:0032269 247 0.357
Human
cellular amine metabolic process GO:0044106 44 0.353
negative regulation of protein maturation GO:1903318 79 0.349
Human
glucose homeostasis GO:0042593 128 0.345
signal transduction involved in dna damage checkpoint GO:0072422 3 0.345
sphingolipid metabolic process GO:0006665 45 0.343
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.337
intussusceptive angiogenesis GO:0002041 2 0.336
axonogenesis GO:0007409 274 0.334
labyrinthine layer blood vessel development GO:0060716 21 0.334
negative regulation of cell migration GO:0030336 59 0.333
Human
anatomical structure homeostasis GO:0060249 145 0.332
cell cycle arrest GO:0007050 37 0.328
Human
leukocyte cell cell adhesion GO:0007159 14 0.327
positive regulation of cell motility GO:2000147 116 0.322
response to radiation GO:0009314 165 0.320
stress activated protein kinase signaling cascade GO:0031098 81 0.319
striated muscle tissue development GO:0014706 293 0.319
positive regulation of fibroblast proliferation GO:0048146 20 0.317
mitotic cell cycle process GO:1903047 159 0.317
regulation of map kinase activity GO:0043405 120 0.317
Human
regulation of cytoskeleton organization GO:0051493 122 0.315
positive regulation of neuron differentiation GO:0045666 141 0.315
signal transduction by p53 class mediator GO:0072331 51 0.315
negative regulation of cell cycle GO:0045786 123 0.313
Human
response to oxygen levels GO:0070482 62 0.312
developmental maturation GO:0021700 193 0.311
Mouse
response to organic cyclic compound GO:0014070 198 0.307
inflammatory response GO:0006954 244 0.307
negative regulation of molecular function GO:0044092 258 0.307
Human
branching morphogenesis of an epithelial tube GO:0048754 159 0.305
endodermal cell differentiation GO:0035987 14 0.299
dendrite development GO:0016358 115 0.297
positive regulation of map kinase activity GO:0043406 84 0.290
Human
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.288
axon guidance GO:0007411 141 0.287
response to endoplasmic reticulum stress GO:0034976 53 0.284
regulation of sphingolipid biosynthetic process GO:0090153 1 0.283
negative regulation of cell growth GO:0030308 44 0.281
oocyte construction GO:0007308 2 0.280
chorio allantoic fusion GO:0060710 8 0.279
organic anion transport GO:0015711 137 0.275
Human
regulation of bmp signaling pathway GO:0030510 60 0.273
covalent chromatin modification GO:0016569 163 0.273
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.265
regulation of cellular response to stress GO:0080135 159 0.264
telencephalon development GO:0021537 186 0.262
cellular response to dna damage stimulus GO:0006974 207 0.262
negative regulation of phosphorylation GO:0042326 166 0.260
forebrain development GO:0030900 302 0.259
cellular response to external stimulus GO:0071496 88 0.257
organonitrogen compound biosynthetic process GO:1901566 192 0.254
oocyte axis specification GO:0007309 2 0.252
cellular amino acid metabolic process GO:0006520 103 0.250
mitotic cell cycle GO:0000278 195 0.249
tissue homeostasis GO:0001894 115 0.249
amine metabolic process GO:0009308 45 0.248
oxidation reduction process GO:0055114 342 0.247
reactive oxygen species metabolic process GO:0072593 84 0.247
Human
neuron projection guidance GO:0097485 141 0.246
regulation of vasculature development GO:1901342 88 0.243
regulation of cellular catabolic process GO:0031329 242 0.242
negative regulation of protein metabolic process GO:0051248 282 0.242
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.241
respiratory tube development GO:0030323 167 0.241
endochondral bone morphogenesis GO:0060350 50 0.240
cellular response to cytokine stimulus GO:0071345 189 0.240
cellular response to hypoxia GO:0071456 17 0.239
positive regulation of hydrolase activity GO:0051345 148 0.238
renal system development GO:0072001 225 0.236
glial cell differentiation GO:0010001 131 0.235
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.235
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.234
negative regulation of cell substrate adhesion GO:0010812 16 0.233
Human
lung development GO:0030324 164 0.232
negative regulation of growth GO:0045926 99 0.231
cellular ketone metabolic process GO:0042180 84 0.229
cellular response to organic cyclic compound GO:0071407 87 0.228
monocarboxylic acid metabolic process GO:0032787 191 0.228
gland development GO:0048732 330 0.228
nephron epithelium development GO:0072009 92 0.227
protein localization to organelle GO:0033365 185 0.225
angiogenesis GO:0001525 201 0.223
epithelial to mesenchymal transition GO:0001837 47 0.220
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.220
regulation of tissue remodeling GO:0034103 38 0.220
Mouse
positive regulation of protein modification process GO:0031401 299 0.220
Human
regulation of cell activation GO:0050865 289 0.220
Human
regulation of actin cytoskeleton organization GO:0032956 84 0.219
peptidyl amino acid modification GO:0018193 336 0.218
chondrocyte development GO:0002063 24 0.217
cell growth GO:0016049 130 0.214
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.212
regulation of cellular amine metabolic process GO:0033238 20 0.212
negative regulation of protein phosphorylation GO:0001933 126 0.212
nuclear transport GO:0051169 139 0.211
regulation of cytokine production GO:0001817 266 0.211
Human
stem cell differentiation GO:0048863 268 0.209
purine nucleotide metabolic process GO:0006163 302 0.209
Human
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.209
actin filament organization GO:0007015 113 0.207
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.206
generation of precursor metabolites and energy GO:0006091 103 0.205
response to nutrient levels GO:0031667 109 0.200
cellular protein catabolic process GO:0044257 155 0.199
bone trabecula morphogenesis GO:0061430 12 0.198
Mouse
appendage development GO:0048736 166 0.197
placenta blood vessel development GO:0060674 31 0.197
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.195
regulation of hydrolase activity GO:0051336 246 0.195
Human
positive regulation of macrophage chemotaxis GO:0010759 5 0.194
positive regulation of neuron projection regeneration GO:0070572 2 0.193
regulation of ceramide biosynthetic process GO:2000303 1 0.191
positive regulation of sphingolipid biosynthetic process GO:0090154 1 0.190
negative regulation of endopeptidase activity GO:0010951 44 0.190
Human
membrane lipid metabolic process GO:0006643 53 0.189
stem cell development GO:0048864 219 0.187
positive regulation of nervous system development GO:0051962 221 0.187
nuclear import GO:0051170 95 0.186
regulation of cellular amino acid metabolic process GO:0006521 5 0.185
kidney mesenchyme morphogenesis GO:0072131 4 0.185
regulation of cell projection organization GO:0031344 206 0.185
negative regulation of cellular component organization GO:0051129 194 0.184
smooth muscle tissue development GO:0048745 22 0.184
bmp signaling pathway GO:0030509 93 0.183
regulation of organelle organization GO:0033043 289 0.181
protein processing GO:0016485 163 0.180
Human
cation transport GO:0006812 399 0.180
regulation of protein import into nucleus GO:0042306 52 0.178
regulation of fibrinolysis GO:0051917 1 0.177
Human
collagen fibril organization GO:0030199 32 0.177
intrinsic apoptotic signaling pathway GO:0097193 132 0.177
kidney development GO:0001822 213 0.176
regulation of endopeptidase activity GO:0052548 89 0.175
Human
mitotic g1 dna damage checkpoint GO:0031571 4 0.174
positive regulation of cell adhesion GO:0045785 80 0.174
regulation of ras protein signal transduction GO:0046578 114 0.173
positive regulation of organelle organization GO:0010638 128 0.172
negative regulation of cellular amine metabolic process GO:0033239 1 0.172
positive regulation of smad protein import into nucleus GO:0060391 2 0.171
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.170
leukocyte chemotaxis GO:0030595 69 0.169
t cell activation GO:0042110 289 0.169
respiratory system development GO:0060541 190 0.169
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.169
Human
positive regulation of apoptotic process GO:0043065 217 0.167
Human
ceramide biosynthetic process GO:0046513 20 0.167
phagocytosis GO:0006909 66 0.162
Human
negative regulation of cell motility GO:2000146 61 0.160
Human
intracellular protein transport GO:0006886 204 0.160
oocyte anterior posterior axis specification GO:0007314 2 0.160
positive regulation of cell migration GO:0030335 109 0.158
cellular response to extracellular stimulus GO:0031668 81 0.158
ear development GO:0043583 200 0.156
locomotory behavior GO:0007626 195 0.153
regulation of intracellular protein transport GO:0033157 82 0.152
ribonucleotide metabolic process GO:0009259 291 0.149
Human
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.149
positive regulation of homeostatic process GO:0032846 64 0.148
response to tumor necrosis factor GO:0034612 26 0.146
negative regulation of vasculature development GO:1901343 26 0.146
regulation of protein localization to nucleus GO:1900180 60 0.146
regulation of protein stability GO:0031647 52 0.145
protein import into nucleus GO:0006606 95 0.145
limb development GO:0060173 166 0.144
negative regulation of osteoblast proliferation GO:0033689 4 0.143
transforming growth factor beta2 production GO:0032906 2 0.143
negative regulation of protein catabolic process GO:0042177 36 0.142
response to corticosteroid GO:0031960 20 0.140
protein targeting GO:0006605 143 0.139
establishment or maintenance of cell polarity GO:0007163 86 0.139
regulation of cell size GO:0008361 72 0.138
ubiquitin dependent protein catabolic process GO:0006511 129 0.137
bone development GO:0060348 120 0.137
regeneration GO:0031099 38 0.136
myeloid cell differentiation GO:0030099 233 0.135
response to hypoxia GO:0001666 58 0.135
muscle contraction GO:0006936 101 0.135
cardiac chamber development GO:0003205 108 0.134
response to inorganic substance GO:0010035 96 0.134
regulation of myeloid leukocyte differentiation GO:0002761 58 0.134
nucleoside phosphate metabolic process GO:0006753 338 0.133
Human
epiboly GO:0090504 8 0.132
modification dependent macromolecule catabolic process GO:0043632 133 0.132
positive regulation of phospholipase activity GO:0010518 3 0.131
cytoplasmic transport GO:0016482 234 0.131
negative regulation of kinase activity GO:0033673 81 0.130
g0 to g1 transition GO:0045023 3 0.130
organic acid transport GO:0015849 101 0.129
Human
hindbrain development GO:0030902 128 0.128
cell cycle g1 s phase transition GO:0044843 57 0.128
cellular lipid metabolic process GO:0044255 323 0.127
trabecula morphogenesis GO:0061383 40 0.127
Mouse
regulation of protein localization GO:0032880 231 0.127
g1 s transition of mitotic cell cycle GO:0000082 57 0.127
single organism nuclear import GO:1902593 95 0.127
ameboidal type cell migration GO:0001667 128 0.125
Human
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.124
regulation of epithelial to mesenchymal transition GO:0010717 22 0.124
hair follicle morphogenesis GO:0031069 29 0.124
regulation of transforming growth factor beta2 production GO:0032909 2 0.123
endoderm formation GO:0001706 20 0.122
negative regulation of protein processing GO:0010955 79 0.122
Human
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.121
negative regulation of cell cycle arrest GO:0071157 1 0.120
regulation of fibroblast proliferation GO:0048145 34 0.120
wnt signaling pathway GO:0016055 188 0.120
regulation of leukocyte apoptotic process GO:2000106 56 0.118
homeostasis of number of cells GO:0048872 210 0.117
positive regulation of cell development GO:0010720 237 0.117
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.117
sensory perception of sound GO:0007605 97 0.116
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.116
actin filament bundle assembly GO:0051017 40 0.116
chondroblast differentiation GO:0060591 2 0.114
positive regulation of apoptotic signaling pathway GO:2001235 95 0.114
Human
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.113
skin morphogenesis GO:0043589 38 0.112
regulation of synaptic transmission glutamatergic GO:0051966 19 0.110
heart morphogenesis GO:0003007 178 0.110
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.110
regulation of protein catabolic process GO:0042176 108 0.109
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.108
dna metabolic process GO:0006259 303 0.108
cellular response to abiotic stimulus GO:0071214 56 0.107
leukocyte apoptotic process GO:0071887 71 0.106
protein modification by small protein conjugation or removal GO:0070647 207 0.106
cellular response to decreased oxygen levels GO:0036294 18 0.106
negative regulation of phosphorus metabolic process GO:0010563 184 0.104
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.104
response to epidermal growth factor GO:0070849 4 0.104
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.103
positive regulation of glial cell proliferation GO:0060252 4 0.103
nucleobase containing small molecule metabolic process GO:0055086 352 0.103
Human
regulation of t cell activation GO:0050863 170 0.103
neutrophil chemotaxis GO:0030593 36 0.103
positive regulation of stem cell differentiation GO:2000738 23 0.102
mitotic nuclear division GO:0007067 48 0.102
regulation of endodermal cell differentiation GO:1903224 2 0.102
regulation of angiogenesis GO:0045765 81 0.102
negative regulation of dna damage response signal transduction by p53 class mediator GO:0043518 5 0.100
prostate gland development GO:0030850 48 0.100
positive regulation of cell cycle GO:0045787 92 0.099
macrophage differentiation GO:0030225 20 0.099
germ cell development GO:0007281 185 0.099
microglia development GO:0014005 2 0.098
modification dependent protein catabolic process GO:0019941 133 0.097
regulation of chondrocyte differentiation GO:0032330 33 0.097
photoreceptor cell morphogenesis GO:0008594 3 0.097
cellular response to oxygen levels GO:0071453 20 0.097
neuronal action potential GO:0019228 54 0.097
regulation of inflammatory response GO:0050727 147 0.097
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.097
Human
positive regulation of protein kinase activity GO:0045860 144 0.096
Human
microglia differentiation GO:0014004 2 0.096
regulation of synaptic plasticity GO:0048167 87 0.096
engulfment of apoptotic cell GO:0043652 3 0.095
Human
actomyosin structure organization GO:0031032 56 0.095
regulation of osteoblast differentiation GO:0045667 67 0.095
erythrocyte differentiation GO:0030218 88 0.095
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.095
bone resorption GO:0045453 38 0.094
negative regulation of map kinase activity GO:0043407 34 0.093
response to amino acid GO:0043200 37 0.093
canonical wnt signaling pathway GO:0060070 130 0.093
positive regulation of leukocyte differentiation GO:1902107 86 0.092
positive regulation of cellular catabolic process GO:0031331 148 0.091
positive regulation of kinase activity GO:0033674 155 0.091
Human
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.090
neutrophil migration GO:1990266 37 0.090
regulation of nucleocytoplasmic transport GO:0046822 73 0.090
nuclear division GO:0000280 158 0.090
regulation of leukocyte differentiation GO:1902105 159 0.089
response to acid chemical GO:0001101 111 0.089
regulation of cell division GO:0051302 76 0.089
cerebellum development GO:0021549 77 0.088
embryonic skeletal system development GO:0048706 120 0.088
microtubule cytoskeleton organization GO:0000226 157 0.087
skeletal muscle organ development GO:0060538 163 0.087
Fly
response to alcohol GO:0097305 48 0.087
associative learning GO:0008306 61 0.086
proteasomal protein catabolic process GO:0010498 98 0.085
establishment of planar polarity GO:0001736 28 0.085
t cell differentiation GO:0030217 174 0.085
cellular macromolecule catabolic process GO:0044265 206 0.084
erk1 and erk2 cascade GO:0070371 77 0.084
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.083
regulation of system process GO:0044057 200 0.082
maternal determination of anterior posterior axis embryo GO:0008358 2 0.081
negative regulation of protein modification process GO:0031400 163 0.080
cell junction organization GO:0034330 77 0.080
positive regulation of keratinocyte proliferation GO:0010838 4 0.080
negative regulation of phosphate metabolic process GO:0045936 184 0.080
regulation of eosinophil migration GO:2000416 2 0.080
dendritic spine maintenance GO:0097062 4 0.080
cytokine mediated signaling pathway GO:0019221 115 0.080
negative regulation of cell cycle process GO:0010948 69 0.079
regulation of ion transport GO:0043269 215 0.079
Human
response to light stimulus GO:0009416 135 0.079
negative regulation of ossification GO:0030279 49 0.078
regulation of transcription factor import into nucleus GO:0042990 24 0.077
cellular response to lipid GO:0071396 145 0.077
regulation of protein maturation GO:1903317 96 0.077
Human
epithelial cell migration GO:0010631 63 0.076
Human
t cell differentiation in thymus GO:0033077 77 0.075
keratinocyte migration GO:0051546 3 0.075
regulation of response to wounding GO:1903034 189 0.074
Human
camera type eye development GO:0043010 266 0.074
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.074
nucleocytoplasmic transport GO:0006913 139 0.073
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.072
positive regulation of protein import into nucleus GO:0042307 26 0.072
female gamete generation GO:0007292 74 0.071
negative regulation of proteolysis GO:0045861 74 0.071
Human
fatty acid derivative metabolic process GO:1901568 33 0.071
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.071
lateral line system development GO:0048925 1 0.071
regulation of cytoplasmic transport GO:1903649 112 0.070
face morphogenesis GO:0060325 29 0.070
cellular response to glucocorticoid stimulus GO:0071385 13 0.070
fatty acid biosynthetic process GO:0006633 41 0.070
myeloid cell homeostasis GO:0002262 114 0.070
embryonic placenta development GO:0001892 98 0.069
regulation of astrocyte differentiation GO:0048710 20 0.069
response to fibroblast growth factor GO:0071774 47 0.069
Human
cell aggregation GO:0098743 18 0.068
metanephric mesenchyme morphogenesis GO:0072133 4 0.068
transmission of nerve impulse GO:0019226 76 0.068
cellular protein complex assembly GO:0043623 116 0.068
appendage morphogenesis GO:0035107 149 0.067
peptide metabolic process GO:0006518 46 0.067
guanosine containing compound catabolic process GO:1901069 144 0.066
epithelium migration GO:0090132 63 0.066
Human
nerve development GO:0021675 67 0.066
response to bmp GO:0071772 14 0.065
regulation of lymphocyte activation GO:0051249 240 0.065
cell proliferation involved in heart valve development GO:2000793 2 0.065
response to extracellular stimulus GO:0009991 127 0.065
formation of primary germ layer GO:0001704 77 0.065
microtubule based process GO:0007017 236 0.065
positive regulation of cell cycle process GO:0090068 61 0.065
embryonic skeletal system morphogenesis GO:0048704 91 0.064
regulation of canonical wnt signaling pathway GO:0060828 82 0.064
tissue regeneration GO:0042246 22 0.064
peptidyl threonine phosphorylation GO:0018107 31 0.064
positive regulation of cartilage development GO:0061036 18 0.064
synaptic transmission GO:0007268 329 0.064
regulation of cellular component size GO:0032535 121 0.064
purine ribonucleotide metabolic process GO:0009150 290 0.063
Human
icosanoid metabolic process GO:0006690 33 0.063
negative regulation of organ growth GO:0046621 17 0.063
cell aging GO:0007569 35 0.063
cell division GO:0051301 120 0.063
regulation of response to dna damage stimulus GO:2001020 34 0.063
ribose phosphate metabolic process GO:0019693 291 0.062
Human
nucleoside metabolic process GO:0009116 246 0.062
proteoglycan metabolic process GO:0006029 38 0.062
anion transport GO:0006820 177 0.062
Human

Thbs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.927
cancer DOID:162 0 0.872
organ system cancer DOID:0050686 0 0.487
disease of anatomical entity DOID:7 0 0.085
musculoskeletal system disease DOID:17 0 0.085
connective tissue disease DOID:65 0 0.085
retinal disease DOID:5679 0 0.078
retinal degeneration DOID:8466 0 0.078
sensory system disease DOID:0050155 0 0.078
eye and adnexa disease DOID:1492 0 0.078
nervous system disease DOID:863 0 0.078
eye disease DOID:5614 0 0.078
kidney cancer DOID:263 0 0.074
urinary system cancer DOID:3996 0 0.074
renal cell carcinoma DOID:4450 0 0.074
renal carcinoma DOID:4451 0 0.074
disease of metabolism DOID:0014667 0 0.071
acquired metabolic disease DOID:0060158 0 0.071