Mus musculus

240 known processes

Ticam1

toll-like receptor adaptor molecule 1

(Aliases: AW046014,TRIF,TICAM-1,AW547018)

Ticam1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to molecule of fungal origin GO:0002238 4 0.985
i kappab kinase nf kappab signaling GO:0007249 85 0.985
cellular response to peptidoglycan GO:0071224 4 0.978
positive regulation of interferon beta production GO:0032728 8 0.927
detection of molecule of bacterial origin GO:0032490 2 0.868
positive regulation of interferon alpha production GO:0032727 4 0.864
positive regulation of interleukin 18 production GO:0032741 2 0.860
toll like receptor signaling pathway GO:0002224 38 0.850
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.848
defense response to other organism GO:0098542 197 0.838
positive regulation of chemokine production GO:0032722 22 0.835
cytokine biosynthetic process GO:0042089 68 0.834
type i interferon biosynthetic process GO:0045351 9 0.832
activation of innate immune response GO:0002218 56 0.822
interleukin 8 production GO:0032637 4 0.811
immune response regulating signaling pathway GO:0002764 125 0.794
pattern recognition receptor signaling pathway GO:0002221 47 0.793
regulation of innate immune response GO:0045088 91 0.771
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.737
response to immune response of other organism involved in symbiotic interaction GO:0052564 3 0.706
regulation of cell activation GO:0050865 289 0.690
regulation of interleukin 18 production GO:0032661 3 0.684
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.683
positive regulation of type i interferon production GO:0032481 14 0.678
interleukin 23 production GO:0032627 2 0.673
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.667
regulation of lymphocyte proliferation GO:0050670 117 0.663
positive regulation of chemokine biosynthetic process GO:0045080 6 0.656
regulation of interferon beta biosynthetic process GO:0045357 4 0.653
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070434 2 0.602
interferon beta biosynthetic process GO:0045350 4 0.600
cytokine production GO:0001816 319 0.596
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.594
regulation of defense response GO:0031347 233 0.562
type i interferon production GO:0032606 29 0.560
interleukin 18 production GO:0032621 4 0.557
activation of immune response GO:0002253 138 0.556
response to bacterial lipoprotein GO:0032493 4 0.546
negative regulation of t cell activation GO:0050868 65 0.525
regulation of interleukin 23 production GO:0032667 2 0.523
regulation of leukocyte proliferation GO:0070663 121 0.511
interleukin 17 production GO:0032620 11 0.510
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.478
cytokine mediated signaling pathway GO:0019221 115 0.474
Mouse
regulation of lymphocyte activation GO:0051249 240 0.457
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.443
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.438
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.437
positive regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070426 2 0.418
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.413
positive regulation of interleukin 8 production GO:0032757 2 0.399
regulation of cytokine biosynthetic process GO:0042035 59 0.397
cellular response to molecule of bacterial origin GO:0071219 83 0.390
positive regulation of interleukin 6 production GO:0032755 37 0.388
lymphocyte proliferation GO:0046651 164 0.380
interferon beta production GO:0032608 16 0.379
positive regulation of b cell activation GO:0050871 49 0.376
cellular response to lipoteichoic acid GO:0071223 6 0.375
modulation by symbiont of defense related host nitric oxide production GO:0052163 1 0.357
negative regulation of t cell proliferation GO:0042130 38 0.354
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.348
regulation of tumor necrosis factor production GO:0032680 49 0.346
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.339
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.332
carbohydrate metabolic process GO:0005975 230 0.327
negative regulation of leukocyte proliferation GO:0070664 46 0.326
induction by organism of defense response of other organism involved in symbiotic interaction GO:0052251 1 0.326
positive regulation of lymphocyte proliferation GO:0050671 70 0.322
positive regulation by symbiont of host defense response GO:0052509 1 0.316
response to host GO:0075136 3 0.310
positive regulation of cytokine biosynthetic process GO:0042108 40 0.308
positive regulation of lymphocyte activation GO:0051251 140 0.306
regulation of type i interferon production GO:0032479 22 0.306
negative regulation of lymphocyte proliferation GO:0050672 45 0.300
response to host immune response GO:0052572 3 0.291
immune response activating signal transduction GO:0002757 116 0.288
regulation of interleukin 17 production GO:0032660 8 0.284
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.281
positive regulation of cell activation GO:0050867 158 0.274
response to defense related host nitric oxide production GO:0052565 2 0.273
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.271
regulation of response to biotic stimulus GO:0002831 38 0.270
growth involved in symbiotic interaction GO:0044110 23 0.267
positive regulation of antimicrobial peptide production GO:0002225 1 0.266
innate immune response activating signal transduction GO:0002758 50 0.266
t cell activation GO:0042110 289 0.264
regulation of interleukin 8 production GO:0032677 3 0.263
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.253
positive regulation of macrophage cytokine production GO:0060907 7 0.253
regulation of cellular ketone metabolic process GO:0010565 66 0.248
regulation of inflammatory response GO:0050727 147 0.248
response to host defenses GO:0052200 3 0.243
positive regulation by symbiont of host immune response GO:0052556 1 0.241
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052302 1 0.240
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.235
negative regulation of hormone biosynthetic process GO:0032353 4 0.233
production of molecular mediator of immune response GO:0002440 103 0.232
response to lipoteichoic acid GO:0070391 6 0.230
cellular response to bacterial lipopeptide GO:0071221 3 0.230
multicellular organismal homeostasis GO:0048871 164 0.230
positive regulation of defense response GO:0031349 124 0.229
modulation by symbiont of host immune response GO:0052553 1 0.229
antimicrobial peptide production GO:0002775 2 0.225
stress activated protein kinase signaling cascade GO:0031098 81 0.225
regulation of cellular amine metabolic process GO:0033238 20 0.223
negative regulation of lymphocyte activation GO:0051250 91 0.223
cellular response to cytokine stimulus GO:0071345 189 0.216
Mouse
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.214
regulation of cellular amino acid metabolic process GO:0006521 5 0.214
nitric oxide synthase biosynthetic process GO:0051767 7 0.211
antibacterial peptide biosynthetic process GO:0002780 2 0.209
response to lipopolysaccharide GO:0032496 128 0.208
response to defenses of other organism involved in symbiotic interaction GO:0052173 3 0.208
induction by symbiont of host immune response GO:0052559 1 0.205
regulation of establishment of protein localization GO:0070201 181 0.202
positive regulation of cytokine production GO:0001819 174 0.202
regulation of secretion GO:0051046 274 0.199
positive regulation of antimicrobial humoral response GO:0002760 2 0.199
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.199
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.197
cellular amino acid metabolic process GO:0006520 103 0.195
regulation of antimicrobial peptide production GO:0002784 1 0.194
chemokine biosynthetic process GO:0042033 8 0.192
cellular amine metabolic process GO:0044106 44 0.192
cellular ketone metabolic process GO:0042180 84 0.190
positive regulation of protein transport GO:0051222 93 0.185
negative regulation of cytokine production GO:0001818 84 0.183
positive regulation by organism of defense response of other organism involved in symbiotic interaction GO:0052510 1 0.182
type i interferon signaling pathway GO:0060337 10 0.181
regionalization GO:0003002 337 0.180
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.175
regulation of macrophage cytokine production GO:0010935 8 0.171
regulation of chemokine production GO:0032642 30 0.169
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.168
response to molecule of bacterial origin GO:0002237 143 0.168
growth of symbiont in host GO:0044117 23 0.166
modification by symbiont of host morphology or physiology GO:0044003 4 0.163
t cell proliferation GO:0042098 120 0.160
negative regulation of cell proliferation GO:0008285 296 0.160
response to bacterial lipopeptide GO:0070339 3 0.159
negative regulation of interleukin 6 production GO:0032715 17 0.158
stress activated mapk cascade GO:0051403 80 0.158
negative regulation of phosphate metabolic process GO:0045936 184 0.158
regulation of interleukin 10 production GO:0032653 21 0.157
positive regulation of leukocyte proliferation GO:0070665 73 0.156
cellular response to biotic stimulus GO:0071216 92 0.155
chemokine metabolic process GO:0050755 10 0.154
cellular response to bacterial lipoprotein GO:0071220 3 0.150
regulation of interferon beta production GO:0032648 13 0.145
positive regulation of interleukin 6 biosynthetic process GO:0045410 6 0.145
regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070432 3 0.144
protein targeting GO:0006605 143 0.141
regulation of antimicrobial humoral response GO:0002759 3 0.141
regulation of natural killer cell activation GO:0032814 22 0.140
regulation of alpha beta t cell activation GO:0046634 53 0.138
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070430 1 0.137
regulation of growth of symbiont in host GO:0044126 19 0.136
regulation of stress activated mapk cascade GO:0032872 69 0.135
regulation of defense response to bacterium GO:1900424 3 0.135
induction by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052263 1 0.134
regulation of b cell proliferation GO:0030888 39 0.134
intracellular receptor signaling pathway GO:0030522 74 0.130
regulation of b cell activation GO:0050864 81 0.129
leukocyte proliferation GO:0070661 172 0.128
regulation of jnk cascade GO:0046328 62 0.128
alpha beta t cell proliferation GO:0046633 21 0.127
regulation of secretion by cell GO:1903530 249 0.127
immune effector process GO:0002252 321 0.126
cellular response to lipid GO:0071396 145 0.126
negative regulation of cell activation GO:0050866 111 0.125
positive regulation of innate immune response GO:0045089 80 0.125
response to organic cyclic compound GO:0014070 198 0.125
negative regulation of growth of symbiont in host GO:0044130 19 0.124
regulation of response to wounding GO:1903034 189 0.124
defense response to bacterium GO:0042742 119 0.123
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052345 1 0.121
antibiotic transport GO:0042891 1 0.120
response to peptidoglycan GO:0032494 9 0.118
inflammatory response GO:0006954 244 0.117
interspecies interaction between organisms GO:0044419 83 0.117
regulation of protein transport GO:0051223 163 0.117
b cell proliferation GO:0042100 53 0.115
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.113
regulation of production of molecular mediator of immune response GO:0002700 65 0.113
regulation of interleukin 1 production GO:0032652 26 0.111
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.110
macromolecule catabolic process GO:0009057 281 0.110
regulation of carbohydrate metabolic process GO:0006109 75 0.108
positive regulation of t cell anergy GO:0002669 4 0.108
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.108
eye photoreceptor cell differentiation GO:0001754 41 0.108
nitric oxide production involved in inflammatory response GO:0002537 2 0.107
negative regulation of interferon gamma production GO:0032689 18 0.106
t cell anergy GO:0002870 4 0.106
regulation of t cell proliferation GO:0042129 92 0.105
positive regulation of jnk cascade GO:0046330 46 0.104
response to dsrna GO:0043331 30 0.104
negative regulation of hormone metabolic process GO:0032351 4 0.104
intestinal epithelial structure maintenance GO:0060729 4 0.103
reactive oxygen species metabolic process GO:0072593 84 0.103
positive regulation of secretion GO:0051047 130 0.101
positive regulation of lymphocyte anergy GO:0002913 4 0.101
microglial cell activation GO:0001774 3 0.100
growth of symbiont involved in interaction with host GO:0044116 23 0.099
regulation of lymphocyte anergy GO:0002911 4 0.098
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.097
negative regulation of phosphorus metabolic process GO:0010563 184 0.097
regulation of defense response to fungus GO:1900150 1 0.097
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.096
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.096
peptidyl tyrosine phosphorylation GO:0018108 143 0.096
macrophage cytokine production GO:0010934 9 0.095
modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 1 0.095
regulation of t cell anergy GO:0002667 4 0.094
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.091
regulation of cellular response to stress GO:0080135 159 0.091
glycoprotein biosynthetic process GO:0009101 89 0.090
tissue homeostasis GO:0001894 115 0.090
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.089
negative regulation of immune system process GO:0002683 209 0.088
positive regulation of interleukin 10 production GO:0032733 12 0.087
b cell activation GO:0042113 161 0.086
regulation of interferon alpha production GO:0032647 5 0.085
glycoprotein metabolic process GO:0009100 116 0.083
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.083
regulation of cytokine production GO:0001817 266 0.082
mapk cascade GO:0000165 281 0.081
t cell homeostasis GO:0043029 35 0.079
regulation of protein kinase activity GO:0045859 232 0.079
programmed necrotic cell death GO:0097300 28 0.078
interleukin 10 production GO:0032613 23 0.078
regulation of alpha beta t cell proliferation GO:0046640 18 0.077
positive regulation of protein modification process GO:0031401 299 0.077
innate immune response GO:0045087 157 0.077
jnk cascade GO:0007254 72 0.075
protein catabolic process GO:0030163 221 0.074
antibacterial peptide production GO:0002778 2 0.073
antigen receptor mediated signaling pathway GO:0050851 64 0.072
negative regulation of protein modification process GO:0031400 163 0.071
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.071
defense response to virus GO:0051607 68 0.069
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.068
detection of lipopolysaccharide GO:0032497 1 0.068
regulation of protein import into nucleus translocation GO:0033158 2 0.068
anatomical structure homeostasis GO:0060249 145 0.066
lymphocyte mediated immunity GO:0002449 139 0.065
regulation of transferase activity GO:0051338 263 0.064
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.063
chloramphenicol transport GO:0042892 1 0.063
regulation of hormone levels GO:0010817 211 0.062
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.062
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.061
b cell activation involved in immune response GO:0002312 50 0.061
3 utr mediated mrna stabilization GO:0070935 2 0.060
intrinsic apoptotic signaling pathway GO:0097193 132 0.060
adaptive immune response GO:0002250 155 0.060
positive regulation of transcription factor import into nucleus GO:0042993 8 0.060
cellular response to organonitrogen compound GO:0071417 145 0.060
positive regulation of secretion by cell GO:1903532 114 0.060
regulation of body fluid levels GO:0050878 162 0.060
defense response to gram positive bacterium GO:0050830 50 0.060
negative regulation of multi organism process GO:0043901 68 0.059
regulation of intracellular protein transport GO:0033157 82 0.058
positive regulation of protein secretion GO:0050714 52 0.057
peptidyl amino acid modification GO:0018193 336 0.056
induction by symbiont of defense related host nitric oxide production GO:0052063 1 0.055
cellular response to lipopolysaccharide GO:0071222 77 0.055
lymphocyte anergy GO:0002249 4 0.055
defense response to gram negative bacterium GO:0050829 28 0.054
regulation of chemokine biosynthetic process GO:0045073 8 0.053
interferon alpha production GO:0032607 7 0.053
positive regulation of mapk cascade GO:0043410 170 0.053
cellular carbohydrate metabolic process GO:0044262 119 0.053
response to organonitrogen compound GO:0010243 246 0.053
sensory organ morphogenesis GO:0090596 242 0.052
response to interleukin 1 GO:0070555 11 0.052
b cell proliferation involved in immune response GO:0002322 5 0.052
cytokine metabolic process GO:0042107 71 0.052
regulation of cytokine secretion GO:0050707 61 0.051
organic acid transport GO:0015849 101 0.051
positive regulation of multi organism process GO:0043902 26 0.050
interleukin 1 mediated signaling pathway GO:0070498 4 0.049
macrophage activation GO:0042116 27 0.049
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.049
cytoplasmic transport GO:0016482 234 0.049
regulation of protein localization GO:0032880 231 0.049
necroptotic process GO:0070266 21 0.048
cellular response to external stimulus GO:0071496 88 0.048
positive regulation of response to biotic stimulus GO:0002833 15 0.048
amine metabolic process GO:0009308 45 0.048
regulation of cell migration GO:0030334 219 0.047
interleukin 6 biosynthetic process GO:0042226 12 0.047
interleukin 6 production GO:0032635 58 0.047
neuronal action potential GO:0019228 54 0.047
protein maturation GO:0051604 176 0.046
membrane organization GO:0061024 245 0.046
protein ubiquitination GO:0016567 171 0.045
sensory perception of pain GO:0019233 47 0.045
negative regulation of interleukin 23 production GO:0032707 1 0.045
regulation of t cell activation GO:0050863 170 0.044
positive regulation of stress activated mapk cascade GO:0032874 48 0.044
nitrogen compound transport GO:0071705 271 0.044
protein secretion GO:0009306 111 0.044
toxin transport GO:1901998 38 0.044
negative regulation of cellular amine metabolic process GO:0033239 1 0.043
regulation of interleukin 6 production GO:0032675 55 0.043
intracellular protein transport GO:0006886 204 0.043
positive regulation of transferase activity GO:0051347 167 0.043
monocarboxylic acid metabolic process GO:0032787 191 0.042
positive regulation of programmed cell death GO:0043068 218 0.042
germ cell development GO:0007281 185 0.042
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.042
positive regulation of intracellular transport GO:0032388 70 0.042
regulation of interleukin 12 production GO:0032655 30 0.041
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.041
fatty acid metabolic process GO:0006631 121 0.041
positive regulation of tumor necrosis factor production GO:0032760 30 0.041
positive regulation of apoptotic process GO:0043065 217 0.041
glial cell apoptotic process GO:0034349 3 0.041
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.040
negative regulation of intracellular signal transduction GO:1902532 167 0.040
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.040
toll like receptor 4 signaling pathway GO:0034142 9 0.040
positive regulation of cytokine secretion GO:0050715 41 0.040
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.040
positive regulation of interleukin 17 production GO:0032740 3 0.040
nucleoside metabolic process GO:0009116 246 0.039
carbohydrate derivative biosynthetic process GO:1901137 183 0.039
positive regulation of interferon gamma production GO:0032729 39 0.039
Mouse
regulation of cell motility GO:2000145 236 0.039
apoptotic signaling pathway GO:0097190 306 0.039
regulation of platelet activation GO:0010543 17 0.038
negative regulation of kinase activity GO:0033673 81 0.038
positive regulation of b cell proliferation GO:0030890 24 0.038
peptide transport GO:0015833 133 0.038
photoreceptor cell differentiation GO:0046530 52 0.037
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.037
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 9 0.037
response to interleukin 12 GO:0070671 2 0.037
Mouse
protein polyubiquitination GO:0000209 33 0.037
cellularization GO:0007349 1 0.037
regulation of mapk cascade GO:0043408 248 0.037
positive regulation of immune effector process GO:0002699 107 0.036
regulation of defense response to virus by host GO:0050691 8 0.036
defense response to fungus GO:0050832 12 0.036
cellular lipid metabolic process GO:0044255 323 0.036
digestion GO:0007586 40 0.036
positive regulation of protein localization to nucleus GO:1900182 30 0.036
positive regulation of interleukin 1 production GO:0032732 17 0.035
necrotic cell death GO:0070265 30 0.035
regulation of acute inflammatory response GO:0002673 27 0.035
interleukin 1 production GO:0032612 31 0.035
somatic diversification of immune receptors GO:0002200 53 0.034
production of molecular mediator involved in inflammatory response GO:0002532 21 0.034
engulfment of apoptotic cell GO:0043652 3 0.034
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.034
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.034
rig i signaling pathway GO:0039529 4 0.033
regulation of defense response to virus GO:0050688 18 0.033
regulation of hydrolase activity GO:0051336 246 0.033
positive regulation by organism of immune response of other organism involved in symbiotic interaction GO:0052555 1 0.033
regulation of protein serine threonine kinase activity GO:0071900 157 0.033
positive regulation of response to cytokine stimulus GO:0060760 11 0.032
Mouse
compound eye development GO:0048749 1 0.032
monocarboxylic acid transport GO:0015718 44 0.032
carboxylic acid transport GO:0046942 100 0.032
immunoglobulin mediated immune response GO:0016064 69 0.032
regulation of rna stability GO:0043487 26 0.032
positive regulation of endopeptidase activity GO:0010950 43 0.032
angiogenesis GO:0001525 201 0.032
response to type i interferon GO:0034340 12 0.032
b cell mediated immunity GO:0019724 71 0.031
regulation of transcription factor import into nucleus GO:0042990 24 0.031
regulation of intracellular transport GO:0032386 159 0.031
immunoglobulin secretion GO:0048305 17 0.031
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.031
regulation of cytoplasmic transport GO:1903649 112 0.031
epithelial structure maintenance GO:0010669 9 0.031
positive regulation of t cell proliferation GO:0042102 52 0.031
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.030
antimicrobial peptide biosynthetic process GO:0002777 2 0.030
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.030
regulation of apoptotic signaling pathway GO:2001233 197 0.030
lymphocyte apoptotic process GO:0070227 54 0.030
dna recombination GO:0006310 92 0.030
positive regulation of protein import into nucleus GO:0042307 26 0.030
regulation of leukocyte differentiation GO:1902105 159 0.029
regulation of endopeptidase activity GO:0052548 89 0.029
negative regulation of inflammatory response GO:0050728 61 0.029
nucleocytoplasmic transport GO:0006913 139 0.029
cell adhesion GO:0007155 329 0.029
regulation of protein targeting GO:1903533 61 0.029
protein localization to organelle GO:0033365 185 0.029
positive regulation of inflammatory response GO:0050729 47 0.029
alpha amino acid metabolic process GO:1901605 59 0.029
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.029
transcription factor import into nucleus GO:0042991 26 0.028
leukocyte mediated immunity GO:0002443 174 0.028
amide transport GO:0042886 138 0.028
drug transport GO:0015893 7 0.028
positive regulation of cytokine production involved in immune response GO:0002720 19 0.027
cellular response to abiotic stimulus GO:0071214 56 0.027
regulation of kinase activity GO:0043549 249 0.027
chemokine production GO:0032602 34 0.027
interaction with host GO:0051701 22 0.027
regulation of protein secretion GO:0050708 82 0.027
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.027
male gamete generation GO:0048232 285 0.027
positive regulation of leukocyte mediated immunity GO:0002705 70 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
coagulation GO:0050817 78 0.027
lipid localization GO:0010876 126 0.026
negative regulation of growth GO:0045926 99 0.026
type 2 immune response GO:0042092 23 0.026
reactive nitrogen species metabolic process GO:2001057 0 0.026
positive regulation of platelet activation GO:0010572 5 0.026
isotype switching GO:0045190 36 0.026
cellular response to oxidative stress GO:0034599 76 0.026
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.026
transmembrane transport GO:0055085 412 0.026
ion transmembrane transport GO:0034220 361 0.025
sensory perception GO:0007600 245 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
response to exogenous dsrna GO:0043330 22 0.024
positive regulation of t cell activation GO:0050870 101 0.024
regulation of mast cell proliferation GO:0070666 4 0.024
skin development GO:0043588 220 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.024
endocytosis GO:0006897 168 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.024
response to peptide hormone GO:0043434 127 0.024
regulation of nucleocytoplasmic transport GO:0046822 73 0.024
alpha beta t cell activation GO:0046631 91 0.024
regulation of response to cytokine stimulus GO:0060759 23 0.023
Mouse
glycosylation GO:0070085 62 0.023
regulation of cytokine production involved in immune response GO:0002718 26 0.023
negative regulation of interleukin 17 production GO:0032700 5 0.023
positive regulation of autophagy GO:0010508 9 0.023
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.023
negative regulation of protein metabolic process GO:0051248 282 0.023
endomembrane system organization GO:0010256 147 0.023
macromolecule glycosylation GO:0043413 55 0.023
lymphocyte differentiation GO:0030098 242 0.023
heterocycle catabolic process GO:0046700 280 0.023
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.023
hormone biosynthetic process GO:0042446 16 0.023
regulation of membrane potential GO:0042391 192 0.023
mitotic cytokinesis GO:0000281 4 0.023
regulation of receptor activity GO:0010469 41 0.023
icosanoid metabolic process GO:0006690 33 0.022
tumor necrosis factor production GO:0032640 50 0.022
regulation of cell cycle GO:0051726 281 0.022
positive regulation of protein catabolic process GO:0045732 60 0.022
positive regulation of intracellular protein transport GO:0090316 42 0.022
regulation of nitric oxide synthase biosynthetic process GO:0051769 7 0.022
regulation of ion transport GO:0043269 215 0.022
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.022
platelet activation GO:0030168 40 0.022
regulation of coagulation GO:0050818 31 0.022
t cell selection GO:0045058 34 0.022
response to acid chemical GO:0001101 111 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.021
sequestering of calcium ion GO:0051208 18 0.021
i kappab phosphorylation GO:0007252 6 0.021
wnt signaling pathway GO:0016055 188 0.021
maintenance of location GO:0051235 89 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
protein glycosylation GO:0006486 55 0.021
translation GO:0006412 93 0.021
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.021
regulation of multi organism process GO:0043900 111 0.021
cellular ion homeostasis GO:0006873 165 0.021
dna metabolic process GO:0006259 303 0.021
cellular amide metabolic process GO:0043603 58 0.021
mast cell proliferation GO:0070662 4 0.021
aromatic compound catabolic process GO:0019439 286 0.021
cytokine secretion GO:0050663 72 0.021
protein modification by small protein conjugation or removal GO:0070647 207 0.021

Ticam1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.201
disease of cellular proliferation DOID:14566 0 0.201
organ system cancer DOID:0050686 0 0.139
immune system cancer DOID:0060083 0 0.076
disease of anatomical entity DOID:7 0 0.072
nervous system disease DOID:863 0 0.072
hematologic cancer DOID:2531 0 0.067
sensory system disease DOID:0050155 0 0.039
eye and adnexa disease DOID:1492 0 0.039
retinal disease DOID:5679 0 0.036
retinal degeneration DOID:8466 0 0.036
eye disease DOID:5614 0 0.036
macular degeneration DOID:4448 0 0.029
large intestine cancer DOID:5672 0 0.022
colon cancer DOID:219 0 0.022
gastrointestinal system cancer DOID:3119 0 0.022
intestinal cancer DOID:10155 0 0.022
colorectal cancer DOID:9256 0 0.022
disease of metabolism DOID:0014667 0 0.021