Mus musculus

240 known processes

Ticam1

toll-like receptor adaptor molecule 1

(Aliases: AW046014,TRIF,TICAM-1,AW547018)

Ticam1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to molecule of fungal origin GO:0002238 4 0.985
i kappab kinase nf kappab signaling GO:0007249 85 0.985
cellular response to peptidoglycan GO:0071224 4 0.978
positive regulation of interferon beta production GO:0032728 8 0.927
detection of molecule of bacterial origin GO:0032490 2 0.868
positive regulation of interferon alpha production GO:0032727 4 0.864
positive regulation of interleukin 18 production GO:0032741 2 0.860
toll like receptor signaling pathway GO:0002224 38 0.850
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.848
defense response to other organism GO:0098542 197 0.838
positive regulation of chemokine production GO:0032722 22 0.835
cytokine biosynthetic process GO:0042089 68 0.834
type i interferon biosynthetic process GO:0045351 9 0.832
activation of innate immune response GO:0002218 56 0.822
interleukin 8 production GO:0032637 4 0.811
immune response regulating signaling pathway GO:0002764 125 0.794
pattern recognition receptor signaling pathway GO:0002221 47 0.793
regulation of innate immune response GO:0045088 91 0.771
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.737
response to immune response of other organism involved in symbiotic interaction GO:0052564 3 0.706
regulation of cell activation GO:0050865 289 0.690
regulation of interleukin 18 production GO:0032661 3 0.684
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.683
positive regulation of type i interferon production GO:0032481 14 0.678
interleukin 23 production GO:0032627 2 0.673
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.667
regulation of lymphocyte proliferation GO:0050670 117 0.663
positive regulation of chemokine biosynthetic process GO:0045080 6 0.656
regulation of interferon beta biosynthetic process GO:0045357 4 0.653
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070434 2 0.602
interferon beta biosynthetic process GO:0045350 4 0.600
cytokine production GO:0001816 319 0.596
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.594
regulation of defense response GO:0031347 233 0.562
type i interferon production GO:0032606 29 0.560
interleukin 18 production GO:0032621 4 0.557
activation of immune response GO:0002253 138 0.556
response to bacterial lipoprotein GO:0032493 4 0.546
negative regulation of t cell activation GO:0050868 65 0.525
regulation of interleukin 23 production GO:0032667 2 0.523
regulation of leukocyte proliferation GO:0070663 121 0.511
interleukin 17 production GO:0032620 11 0.510
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.478
cytokine mediated signaling pathway GO:0019221 115 0.474
Mouse
regulation of lymphocyte activation GO:0051249 240 0.457
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.443
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.438
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.437
positive regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070426 2 0.418
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.413
positive regulation of interleukin 8 production GO:0032757 2 0.399
regulation of cytokine biosynthetic process GO:0042035 59 0.397
cellular response to molecule of bacterial origin GO:0071219 83 0.390
positive regulation of interleukin 6 production GO:0032755 37 0.388
lymphocyte proliferation GO:0046651 164 0.380
interferon beta production GO:0032608 16 0.379
positive regulation of b cell activation GO:0050871 49 0.376
cellular response to lipoteichoic acid GO:0071223 6 0.375
modulation by symbiont of defense related host nitric oxide production GO:0052163 1 0.357
negative regulation of t cell proliferation GO:0042130 38 0.354
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.348
regulation of tumor necrosis factor production GO:0032680 49 0.346
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.339
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.332
carbohydrate metabolic process GO:0005975 230 0.327
negative regulation of leukocyte proliferation GO:0070664 46 0.326
induction by organism of defense response of other organism involved in symbiotic interaction GO:0052251 1 0.326
positive regulation of lymphocyte proliferation GO:0050671 70 0.322
positive regulation by symbiont of host defense response GO:0052509 1 0.316
response to host GO:0075136 3 0.310
positive regulation of cytokine biosynthetic process GO:0042108 40 0.308
positive regulation of lymphocyte activation GO:0051251 140 0.306
regulation of type i interferon production GO:0032479 22 0.306
negative regulation of lymphocyte proliferation GO:0050672 45 0.300
response to host immune response GO:0052572 3 0.291
immune response activating signal transduction GO:0002757 116 0.288
regulation of interleukin 17 production GO:0032660 8 0.284
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.281
positive regulation of cell activation GO:0050867 158 0.274
response to defense related host nitric oxide production GO:0052565 2 0.273
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.271
regulation of response to biotic stimulus GO:0002831 38 0.270
growth involved in symbiotic interaction GO:0044110 23 0.267
positive regulation of antimicrobial peptide production GO:0002225 1 0.266
innate immune response activating signal transduction GO:0002758 50 0.266
t cell activation GO:0042110 289 0.264
regulation of interleukin 8 production GO:0032677 3 0.263
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.253
positive regulation of macrophage cytokine production GO:0060907 7 0.253
regulation of cellular ketone metabolic process GO:0010565 66 0.248
regulation of inflammatory response GO:0050727 147 0.248
response to host defenses GO:0052200 3 0.243
positive regulation by symbiont of host immune response GO:0052556 1 0.241
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052302 1 0.240
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.235
negative regulation of hormone biosynthetic process GO:0032353 4 0.233
production of molecular mediator of immune response GO:0002440 103 0.232
response to lipoteichoic acid GO:0070391 6 0.230
cellular response to bacterial lipopeptide GO:0071221 3 0.230
multicellular organismal homeostasis GO:0048871 164 0.230
positive regulation of defense response GO:0031349 124 0.229
modulation by symbiont of host immune response GO:0052553 1 0.229
antimicrobial peptide production GO:0002775 2 0.225
stress activated protein kinase signaling cascade GO:0031098 81 0.225
regulation of cellular amine metabolic process GO:0033238 20 0.223
negative regulation of lymphocyte activation GO:0051250 91 0.223
cellular response to cytokine stimulus GO:0071345 189 0.216
Mouse
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.214
regulation of cellular amino acid metabolic process GO:0006521 5 0.214
nitric oxide synthase biosynthetic process GO:0051767 7 0.211
antibacterial peptide biosynthetic process GO:0002780 2 0.209
response to lipopolysaccharide GO:0032496 128 0.208
response to defenses of other organism involved in symbiotic interaction GO:0052173 3 0.208
induction by symbiont of host immune response GO:0052559 1 0.205
regulation of establishment of protein localization GO:0070201 181 0.202
positive regulation of cytokine production GO:0001819 174 0.202
regulation of secretion GO:0051046 274 0.199
positive regulation of antimicrobial humoral response GO:0002760 2 0.199
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.199
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.197
cellular amino acid metabolic process GO:0006520 103 0.195
regulation of antimicrobial peptide production GO:0002784 1 0.194
chemokine biosynthetic process GO:0042033 8 0.192
cellular amine metabolic process GO:0044106 44 0.192
cellular ketone metabolic process GO:0042180 84 0.190
positive regulation of protein transport GO:0051222 93 0.185
negative regulation of cytokine production GO:0001818 84 0.183
positive regulation by organism of defense response of other organism involved in symbiotic interaction GO:0052510 1 0.182
type i interferon signaling pathway GO:0060337 10 0.181
regionalization GO:0003002 337 0.180
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.175
regulation of macrophage cytokine production GO:0010935 8 0.171
regulation of chemokine production GO:0032642 30 0.169
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.168
response to molecule of bacterial origin GO:0002237 143 0.168
growth of symbiont in host GO:0044117 23 0.166
modification by symbiont of host morphology or physiology GO:0044003 4 0.163
t cell proliferation GO:0042098 120 0.160
negative regulation of cell proliferation GO:0008285 296 0.160
response to bacterial lipopeptide GO:0070339 3 0.159
negative regulation of interleukin 6 production GO:0032715 17 0.158
stress activated mapk cascade GO:0051403 80 0.158
negative regulation of phosphate metabolic process GO:0045936 184 0.158
regulation of interleukin 10 production GO:0032653 21 0.157
positive regulation of leukocyte proliferation GO:0070665 73 0.156
cellular response to biotic stimulus GO:0071216 92 0.155
chemokine metabolic process GO:0050755 10 0.154
cellular response to bacterial lipoprotein GO:0071220 3 0.150
regulation of interferon beta production GO:0032648 13 0.145
positive regulation of interleukin 6 biosynthetic process GO:0045410 6 0.145
regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070432 3 0.144
protein targeting GO:0006605 143 0.141
regulation of antimicrobial humoral response GO:0002759 3 0.141
regulation of natural killer cell activation GO:0032814 22 0.140
regulation of alpha beta t cell activation GO:0046634 53 0.138
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070430 1 0.137
regulation of growth of symbiont in host GO:0044126 19 0.136
regulation of stress activated mapk cascade GO:0032872 69 0.135
regulation of defense response to bacterium GO:1900424 3 0.135
induction by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052263 1 0.134
regulation of b cell proliferation GO:0030888 39 0.134
intracellular receptor signaling pathway GO:0030522 74 0.130
regulation of b cell activation GO:0050864 81 0.129
leukocyte proliferation GO:0070661 172 0.128
regulation of jnk cascade GO:0046328 62 0.128
alpha beta t cell proliferation GO:0046633 21 0.127
regulation of secretion by cell GO:1903530 249 0.127
immune effector process GO:0002252 321 0.126
cellular response to lipid GO:0071396 145 0.126
negative regulation of cell activation GO:0050866 111 0.125
positive regulation of innate immune response GO:0045089 80 0.125
response to organic cyclic compound GO:0014070 198 0.125
negative regulation of growth of symbiont in host GO:0044130 19 0.124
regulation of response to wounding GO:1903034 189 0.124
defense response to bacterium GO:0042742 119 0.123
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052345 1 0.121
antibiotic transport GO:0042891 1 0.120
response to peptidoglycan GO:0032494 9 0.118
inflammatory response GO:0006954 244 0.117
interspecies interaction between organisms GO:0044419 83 0.117
regulation of protein transport GO:0051223 163 0.117
b cell proliferation GO:0042100 53 0.115
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.113
regulation of production of molecular mediator of immune response GO:0002700 65 0.113
regulation of interleukin 1 production GO:0032652 26 0.111
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.110
macromolecule catabolic process GO:0009057 281 0.110
regulation of carbohydrate metabolic process GO:0006109 75 0.108
positive regulation of t cell anergy GO:0002669 4 0.108
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.108
eye photoreceptor cell differentiation GO:0001754 41 0.108
nitric oxide production involved in inflammatory response GO:0002537 2 0.107
negative regulation of interferon gamma production GO:0032689 18 0.106
t cell anergy GO:0002870 4 0.106
regulation of t cell proliferation GO:0042129 92 0.105
positive regulation of jnk cascade GO:0046330 46 0.104
response to dsrna GO:0043331 30 0.104
negative regulation of hormone metabolic process GO:0032351 4 0.104
intestinal epithelial structure maintenance GO:0060729 4 0.103
reactive oxygen species metabolic process GO:0072593 84 0.103
positive regulation of secretion GO:0051047 130 0.101
positive regulation of lymphocyte anergy GO:0002913 4 0.101
microglial cell activation GO:0001774 3 0.100
growth of symbiont involved in interaction with host GO:0044116 23 0.099
regulation of lymphocyte anergy GO:0002911 4 0.098
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.097
negative regulation of phosphorus metabolic process GO:0010563 184 0.097
regulation of defense response to fungus GO:1900150 1 0.097
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.096
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.096
peptidyl tyrosine phosphorylation GO:0018108 143 0.096
macrophage cytokine production GO:0010934 9 0.095
modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 1 0.095
regulation of t cell anergy GO:0002667 4 0.094
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.091
regulation of cellular response to stress GO:0080135 159 0.091
glycoprotein biosynthetic process GO:0009101 89 0.090
tissue homeostasis GO:0001894 115 0.090
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.089
negative regulation of immune system process GO:0002683 209 0.088
positive regulation of interleukin 10 production GO:0032733 12 0.087
b cell activation GO:0042113 161 0.086
regulation of interferon alpha production GO:0032647 5 0.085
glycoprotein metabolic process GO:0009100 116 0.083
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.083
regulation of cytokine production GO:0001817 266 0.082
mapk cascade GO:0000165 281 0.081
t cell homeostasis GO:0043029 35 0.079
regulation of protein kinase activity GO:0045859 232 0.079
programmed necrotic cell death GO:0097300 28 0.078
interleukin 10 production GO:0032613 23 0.078
regulation of alpha beta t cell proliferation GO:0046640 18 0.077
positive regulation of protein modification process GO:0031401 299 0.077
innate immune response GO:0045087 157 0.077
jnk cascade GO:0007254 72 0.075
protein catabolic process GO:0030163 221 0.074
antibacterial peptide production GO:0002778 2 0.073
antigen receptor mediated signaling pathway GO:0050851 64 0.072
negative regulation of protein modification process GO:0031400 163 0.071
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.071
defense response to virus GO:0051607 68 0.069
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.068
detection of lipopolysaccharide GO:0032497 1 0.068
regulation of protein import into nucleus translocation GO:0033158 2 0.068
anatomical structure homeostasis GO:0060249 145 0.066
lymphocyte mediated immunity GO:0002449 139 0.065
regulation of transferase activity GO:0051338 263 0.064
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.063
chloramphenicol transport GO:0042892 1 0.063
regulation of hormone levels GO:0010817 211 0.062
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.062
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.061
b cell activation involved in immune response GO:0002312 50 0.061
3 utr mediated mrna stabilization GO:0070935 2 0.060
intrinsic apoptotic signaling pathway GO:0097193 132 0.060
adaptive immune response GO:0002250 155 0.060
positive regulation of transcription factor import into nucleus GO:0042993 8 0.060
cellular response to organonitrogen compound GO:0071417 145 0.060
positive regulation of secretion by cell GO:1903532 114 0.060
regulation of body fluid levels GO:0050878 162 0.060
defense response to gram positive bacterium GO:0050830 50 0.060
negative regulation of multi organism process GO:0043901 68 0.059
regulation of intracellular protein transport GO:0033157 82 0.058
positive regulation of protein secretion GO:0050714 52 0.057
peptidyl amino acid modification GO:0018193 336 0.056
induction by symbiont of defense related host nitric oxide production GO:0052063 1 0.055
cellular response to lipopolysaccharide GO:0071222 77 0.055
lymphocyte anergy GO:0002249 4 0.055
defense response to gram negative bacterium GO:0050829 28 0.054
regulation of chemokine biosynthetic process GO:0045073 8 0.053
interferon alpha production GO:0032607 7 0.053
positive regulation of mapk cascade GO:0043410 170 0.053
cellular carbohydrate metabolic process GO:0044262 119 0.053
response to organonitrogen compound GO:0010243 246 0.053
sensory organ morphogenesis GO:0090596 242 0.052
response to interleukin 1 GO:0070555 11 0.052
b cell proliferation involved in immune response GO:0002322 5 0.052
cytokine metabolic process GO:0042107 71 0.052
regulation of cytokine secretion GO:0050707 61 0.051
organic acid transport GO:0015849 101 0.051
positive regulation of multi organism process GO:0043902 26 0.050
interleukin 1 mediated signaling pathway GO:0070498 4 0.049
macrophage activation GO:0042116 27 0.049
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.049
cytoplasmic transport GO:0016482 234 0.049
regulation of protein localization GO:0032880 231 0.049
necroptotic process GO:0070266 21 0.048
cellular response to external stimulus GO:0071496 88 0.048
positive regulation of response to biotic stimulus GO:0002833 15 0.048
amine metabolic process GO:0009308 45 0.048
regulation of cell migration GO:0030334 219 0.047
interleukin 6 biosynthetic process GO:0042226 12 0.047
interleukin 6 production GO:0032635 58 0.047
neuronal action potential GO:0019228 54 0.047
protein maturation GO:0051604 176 0.046
membrane organization GO:0061024 245 0.046
protein ubiquitination GO:0016567 171 0.045
sensory perception of pain GO:0019233 47 0.045
negative regulation of interleukin 23 production GO:0032707 1 0.045
regulation of t cell activation GO:0050863 170 0.044
positive regulation of stress activated mapk cascade GO:0032874 48 0.044
nitrogen compound transport GO:0071705 271 0.044
protein secretion GO:0009306 111 0.044
toxin transport GO:1901998 38 0.044
negative regulation of cellular amine metabolic process GO:0033239 1 0.043
regulation of interleukin 6 production GO:0032675 55 0.043
intracellular protein transport GO:0006886 204 0.043
positive regulation of transferase activity GO:0051347 167 0.043
monocarboxylic acid metabolic process GO:0032787 191 0.042
positive regulation of programmed cell death GO:0043068 218 0.042
germ cell development GO:0007281 185 0.042
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.042
positive regulation of intracellular transport GO:0032388 70 0.042
regulation of interleukin 12 production GO:0032655 30 0.041
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.041
fatty acid metabolic process GO:0006631 121 0.041
positive regulation of tumor necrosis factor production GO:0032760 30 0.041
positive regulation of apoptotic process GO:0043065 217 0.041
glial cell apoptotic process GO:0034349 3 0.041
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.040
negative regulation of intracellular signal transduction GO:1902532 167 0.040
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.040
toll like receptor 4 signaling pathway GO:0034142 9 0.040
positive regulation of cytokine secretion GO:0050715 41 0.040
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.040
positive regulation of interleukin 17 production GO:0032740 3 0.040
nucleoside metabolic process GO:0009116 246 0.039
carbohydrate derivative biosynthetic process GO:1901137 183 0.039
positive regulation of interferon gamma production GO:0032729 39 0.039
Mouse
regulation of cell motility GO:2000145 236 0.039
apoptotic signaling pathway GO:0097190 306 0.039
regulation of platelet activation GO:0010543 17 0.038
negative regulation of kinase activity GO:0033673 81 0.038
positive regulation of b cell proliferation GO:0030890 24 0.038
peptide transport GO:0015833 133 0.038
photoreceptor cell differentiation GO:0046530 52 0.037
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.037
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 9 0.037
response to interleukin 12 GO:0070671 2 0.037
Mouse
protein polyubiquitination GO:0000209 33 0.037
cellularization GO:0007349 1 0.037
regulation of mapk cascade GO:0043408 248 0.037
positive regulation of immune effector process GO:0002699 107 0.036
regulation of defense response to virus by host GO:0050691 8 0.036
defense response to fungus GO:0050832 12 0.036
cellular lipid metabolic process GO:0044255 323 0.036
digestion GO:0007586 40 0.036
positive regulation of protein localization to nucleus GO:1900182 30 0.036
positive regulation of interleukin 1 production GO:0032732 17 0.035
necrotic cell death GO:0070265 30 0.035
regulation of acute inflammatory response GO:0002673 27 0.035
interleukin 1 production GO:0032612 31 0.035
somatic diversification of immune receptors GO:0002200 53 0.034
production of molecular mediator involved in inflammatory response GO:0002532 21 0.034
engulfment of apoptotic cell GO:0043652 3 0.034
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.034
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.034
rig i signaling pathway GO:0039529 4 0.033
regulation of defense response to virus GO:0050688 18 0.033
regulation of hydrolase activity GO:0051336 246 0.033
positive regulation by organism of immune response of other organism involved in symbiotic interaction GO:0052555 1 0.033
regulation of protein serine threonine kinase activity GO:0071900 157 0.033
positive regulation of response to cytokine stimulus GO:0060760 11 0.032
Mouse
compound eye development GO:0048749 1 0.032
monocarboxylic acid transport GO:0015718 44 0.032
carboxylic acid transport GO:0046942 100 0.032
immunoglobulin mediated immune response GO:0016064 69 0.032
regulation of rna stability GO:0043487 26 0.032
positive regulation of endopeptidase activity GO:0010950 43 0.032
angiogenesis GO:0001525 201 0.032
response to type i interferon GO:0034340 12 0.032
b cell mediated immunity GO:0019724 71 0.031
regulation of transcription factor import into nucleus GO:0042990 24 0.031
regulation of intracellular transport GO:0032386 159 0.031
immunoglobulin secretion GO:0048305 17 0.031
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.031
regulation of cytoplasmic transport GO:1903649 112 0.031
epithelial structure maintenance GO:0010669 9 0.031
positive regulation of t cell proliferation GO:0042102 52 0.031
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.030
antimicrobial peptide biosynthetic process GO:0002777 2 0.030
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.030
regulation of apoptotic signaling pathway GO:2001233 197 0.030
lymphocyte apoptotic process GO:0070227 54 0.030
dna recombination GO:0006310 92 0.030
positive regulation of protein import into nucleus GO:0042307 26 0.030
regulation of leukocyte differentiation GO:1902105 159 0.029
regulation of endopeptidase activity GO:0052548 89 0.029
negative regulation of inflammatory response GO:0050728 61 0.029
nucleocytoplasmic transport GO:0006913 139 0.029
cell adhesion GO:0007155 329 0.029
regulation of protein targeting GO:1903533 61 0.029
protein localization to organelle GO:0033365 185 0.029
positive regulation of inflammatory response GO:0050729 47 0.029
alpha amino acid metabolic process GO:1901605 59 0.029
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.029
transcription factor import into nucleus GO:0042991 26 0.028
leukocyte mediated immunity GO:0002443 174 0.028
amide transport GO:0042886 138 0.028
drug transport GO:0015893 7 0.028
positive regulation of cytokine production involved in immune response GO:0002720 19 0.027
cellular response to abiotic stimulus GO:0071214 56 0.027
regulation of kinase activity GO:0043549 249 0.027
chemokine production GO:0032602 34 0.027
interaction with host GO:0051701 22 0.027
regulation of protein secretion GO:0050708 82 0.027
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.027
male gamete generation GO:0048232 285 0.027
positive regulation of leukocyte mediated immunity GO:0002705 70 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
coagulation GO:0050817 78 0.027
lipid localization GO:0010876 126 0.026
negative regulation of growth GO:0045926 99 0.026
type 2 immune response GO:0042092 23 0.026
reactive nitrogen species metabolic process GO:2001057 0 0.026
positive regulation of platelet activation GO:0010572 5 0.026
isotype switching GO:0045190 36 0.026
cellular response to oxidative stress GO:0034599 76 0.026
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.026
transmembrane transport GO:0055085 412 0.026
ion transmembrane transport GO:0034220 361 0.025
sensory perception GO:0007600 245 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
response to exogenous dsrna GO:0043330 22 0.024
positive regulation of t cell activation GO:0050870 101 0.024
regulation of mast cell proliferation GO:0070666 4 0.024
skin development GO:0043588 220 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.024
endocytosis GO:0006897 168 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.024
response to peptide hormone GO:0043434 127 0.024
regulation of nucleocytoplasmic transport GO:0046822 73 0.024
alpha beta t cell activation GO:0046631 91 0.024
regulation of response to cytokine stimulus GO:0060759 23 0.023
Mouse
glycosylation GO:0070085 62 0.023
regulation of cytokine production involved in immune response GO:0002718 26 0.023
negative regulation of interleukin 17 production GO:0032700 5 0.023
positive regulation of autophagy GO:0010508 9 0.023
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.023
negative regulation of protein metabolic process GO:0051248 282 0.023
endomembrane system organization GO:0010256 147 0.023
macromolecule glycosylation GO:0043413 55 0.023
lymphocyte differentiation GO:0030098 242 0.023
heterocycle catabolic process GO:0046700 280 0.023
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.023
hormone biosynthetic process GO:0042446 16 0.023
regulation of membrane potential GO:0042391 192 0.023
mitotic cytokinesis GO:0000281 4 0.023
regulation of receptor activity GO:0010469 41 0.023
icosanoid metabolic process GO:0006690 33 0.022
tumor necrosis factor production GO:0032640 50 0.022
regulation of cell cycle GO:0051726 281 0.022
positive regulation of protein catabolic process GO:0045732 60 0.022
positive regulation of intracellular protein transport GO:0090316 42 0.022
regulation of nitric oxide synthase biosynthetic process GO:0051769 7 0.022
regulation of ion transport GO:0043269 215 0.022
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.022
platelet activation GO:0030168 40 0.022
regulation of coagulation GO:0050818 31 0.022
t cell selection GO:0045058 34 0.022
response to acid chemical GO:0001101 111 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.021
sequestering of calcium ion GO:0051208 18 0.021
i kappab phosphorylation GO:0007252 6 0.021
wnt signaling pathway GO:0016055 188 0.021
maintenance of location GO:0051235 89 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
protein glycosylation GO:0006486 55 0.021
translation GO:0006412 93 0.021
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.021
regulation of multi organism process GO:0043900 111 0.021
cellular ion homeostasis GO:0006873 165 0.021
dna metabolic process GO:0006259 303 0.021
cellular amide metabolic process GO:0043603 58 0.021
mast cell proliferation GO:0070662 4 0.021
aromatic compound catabolic process GO:0019439 286 0.021
cytokine secretion GO:0050663 72 0.021
protein modification by small protein conjugation or removal GO:0070647 207 0.021

Ticam1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.201
cancer DOID:162 0 0.201
organ system cancer DOID:0050686 0 0.139
immune system cancer DOID:0060083 0 0.076
nervous system disease DOID:863 0 0.072
disease of anatomical entity DOID:7 0 0.072
hematologic cancer DOID:2531 0 0.067
sensory system disease DOID:0050155 0 0.039
eye and adnexa disease DOID:1492 0 0.039
retinal disease DOID:5679 0 0.036
retinal degeneration DOID:8466 0 0.036
eye disease DOID:5614 0 0.036
macular degeneration DOID:4448 0 0.029
gastrointestinal system cancer DOID:3119 0 0.022
intestinal cancer DOID:10155 0 0.022
colorectal cancer DOID:9256 0 0.022
large intestine cancer DOID:5672 0 0.022
colon cancer DOID:219 0 0.022
disease of metabolism DOID:0014667 0 0.021