Mus musculus

0 known processes

Tlr8

toll-like receptor 8

Tlr8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 197 0.745
Human Mouse
detection of yeast GO:0001879 2 0.738
innate immune response GO:0045087 157 0.550
Human Mouse
detection of fungus GO:0016046 2 0.535
activation of innate immune response GO:0002218 56 0.473
Mouse
immune response activating signal transduction GO:0002757 116 0.451
Mouse
regulation of innate immune response GO:0045088 91 0.442
Human Mouse
regulation of cell activation GO:0050865 289 0.437
Mouse
cytokine production GO:0001816 319 0.421
Human Mouse
positive regulation of innate immune response GO:0045089 80 0.396
Human Mouse
immune effector process GO:0002252 321 0.388
Human Mouse
activation of immune response GO:0002253 138 0.364
Mouse
inflammatory response GO:0006954 244 0.356
Mouse
regulation of defense response GO:0031347 233 0.301
Human Mouse
regulation of establishment of protein localization GO:0070201 181 0.301
Mouse
detection of external biotic stimulus GO:0098581 9 0.300
regulation of secretion GO:0051046 274 0.298
Mouse
sequestering of metal ion GO:0051238 19 0.289
positive regulation of immune effector process GO:0002699 107 0.275
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.271
Mouse
immune response regulating signaling pathway GO:0002764 125 0.264
Mouse
divalent inorganic cation transport GO:0072511 178 0.263
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.262
Mouse
detection of bacterium GO:0016045 7 0.248
leukocyte activation involved in immune response GO:0002366 126 0.246
Mouse
regulation of secretion by cell GO:1903530 249 0.242
Mouse
cellular amino acid metabolic process GO:0006520 103 0.237
cation transport GO:0006812 399 0.234
positive regulation of defense response GO:0031349 124 0.229
Human Mouse
negative regulation of immune system process GO:0002683 209 0.219
lymphocyte proliferation GO:0046651 164 0.199
Mouse
regulation of cell migration GO:0030334 219 0.198
Mouse
t cell activation GO:0042110 289 0.190
regulation of vesicle mediated transport GO:0060627 139 0.186
regulation of cytokine production GO:0001817 266 0.182
Human Mouse
negative regulation of immune effector process GO:0002698 55 0.175
cellular response to molecule of bacterial origin GO:0071219 83 0.174
Mouse
leukocyte chemotaxis GO:0030595 69 0.174
cellular response to lipopolysaccharide GO:0071222 77 0.172
Mouse
negative regulation of serotonin secretion GO:0014063 2 0.171
detection of other organism GO:0098543 8 0.170
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.169
leukocyte migration GO:0050900 124 0.167
Mouse
sequestering of calcium ion GO:0051208 18 0.161
defense response to bacterium GO:0042742 119 0.152
Mouse
cellular amine metabolic process GO:0044106 44 0.148
regulation of cytokine secretion GO:0050707 61 0.148
Mouse
defense response to gram positive bacterium GO:0050830 50 0.147
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.145
membrane organization GO:0061024 245 0.144
leukocyte mediated immunity GO:0002443 174 0.144
innate immune response activating signal transduction GO:0002758 50 0.142
Mouse
release of sequestered calcium ion into cytosol GO:0051209 42 0.142
detection of biotic stimulus GO:0009595 10 0.140
cellular response to biotic stimulus GO:0071216 92 0.139
Mouse
divalent metal ion transport GO:0070838 172 0.136
regulation of lymphocyte proliferation GO:0050670 117 0.134
Mouse
regulation of t cell proliferation GO:0042129 92 0.132
humoral immune response GO:0006959 57 0.132
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.131
cytokine secretion GO:0050663 72 0.130
Mouse
cell activation involved in immune response GO:0002263 126 0.129
Mouse
negative regulation of leukocyte mediated immunity GO:0002704 29 0.128
regulation of protein secretion GO:0050708 82 0.126
Mouse
cell chemotaxis GO:0060326 81 0.125
chemotaxis GO:0006935 247 0.125
cellular ketone metabolic process GO:0042180 84 0.123
regulation of cell motility GO:2000145 236 0.123
Mouse
positive regulation of phagocytosis GO:0050766 26 0.122
phagocytosis GO:0006909 66 0.120
cellular response to cytokine stimulus GO:0071345 189 0.119
g protein coupled receptor signaling pathway GO:0007186 243 0.117
calcium ion homeostasis GO:0055074 127 0.114
cation homeostasis GO:0055080 212 0.110
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.108
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.107
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.106
regulation of protein localization GO:0032880 231 0.102
Mouse
negative regulation of leukocyte proliferation GO:0070664 46 0.102
positive regulation of toll like receptor 9 signaling pathway GO:0034165 2 0.102
keratinocyte migration GO:0051546 3 0.095
regulation of ion transport GO:0043269 215 0.094
cytokine biosynthetic process GO:0042089 68 0.094
Human Mouse
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.092
Mouse
regulation of cytokine biosynthetic process GO:0042035 59 0.092
Human Mouse
amine metabolic process GO:0009308 45 0.092
positive regulation of cytokine production GO:0001819 174 0.091
Human Mouse
t cell proliferation GO:0042098 120 0.091
regulation of leukocyte proliferation GO:0070663 121 0.090
Mouse
negative regulation of t cell proliferation GO:0042130 38 0.089
protein secretion GO:0009306 111 0.088
Mouse
positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8 0.086
Mouse
blood vessel morphogenesis GO:0048514 285 0.085
neutrophil chemotaxis GO:0030593 36 0.085
endocytosis GO:0006897 168 0.085
immunoglobulin transcytosis in epithelial cells GO:0002414 2 0.085
angiogenesis GO:0001525 201 0.085
positive regulation of cellular amine metabolic process GO:0033240 5 0.085
serotonin secretion by mast cell GO:0002552 1 0.084
regulation of response to wounding GO:1903034 189 0.083
Mouse
regulation of system process GO:0044057 200 0.083
regulation of vasculature development GO:1901342 88 0.082
regulation of angiogenesis GO:0045765 81 0.082
regulation of ion homeostasis GO:2000021 64 0.082
response to molecule of bacterial origin GO:0002237 143 0.079
Mouse
regulation of protein transport GO:0051223 163 0.079
Mouse
calcium mediated signaling GO:0019722 46 0.079
cytokine metabolic process GO:0042107 71 0.078
Human Mouse
regulation of inflammatory response GO:0050727 147 0.077
Mouse
regulation of lymphocyte activation GO:0051249 240 0.077
Mouse
adaptive immune response GO:0002250 155 0.077
regulation of tumor necrosis factor production GO:0032680 49 0.076
Mouse
second messenger mediated signaling GO:0019932 73 0.074
metal ion homeostasis GO:0055065 189 0.072
eosinophil degranulation GO:0043308 1 0.071
cellular homeostasis GO:0019725 240 0.071
positive regulation of monocyte chemotaxis GO:0090026 2 0.071
regulation of cytoplasmic transport GO:1903649 112 0.071
oxidation reduction process GO:0055114 342 0.071
regulation of cellular ketone metabolic process GO:0010565 66 0.070
cellular ion homeostasis GO:0006873 165 0.069
cellular response to organonitrogen compound GO:0071417 145 0.068
Mouse
positive regulation of cell activation GO:0050867 158 0.068
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.068
negative regulation of mast cell degranulation GO:0043305 4 0.067
fat cell differentiation GO:0045444 160 0.065
positive regulation of cytokine biosynthetic process GO:0042108 40 0.064
Human Mouse
interleukin 6 production GO:0032635 58 0.064
Mouse
alpha beta t cell activation GO:0046631 91 0.063
leukocyte differentiation GO:0002521 342 0.062
peptidyl amino acid modification GO:0018193 336 0.061
cytosolic calcium ion transport GO:0060401 48 0.061
myeloid leukocyte migration GO:0097529 57 0.059
negative regulation of molecular function GO:0044092 258 0.059
regulation of calcium ion transport into cytosol GO:0010522 31 0.059
positive regulation of angiogenesis GO:0045766 46 0.059
cellular calcium ion homeostasis GO:0006874 119 0.058
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.058
Mouse
maintenance of location GO:0051235 89 0.057
negative regulation of cellular protein metabolic process GO:0032269 247 0.057
regulation of lymphocyte mediated immunity GO:0002706 84 0.057
regulation of cellular amino acid metabolic process GO:0006521 5 0.057
antigen processing and presentation GO:0019882 47 0.056
positive regulation of homeostatic process GO:0032846 64 0.056
calcium ion transport GO:0006816 159 0.056
myeloid cell differentiation GO:0030099 233 0.055
cellular chemical homeostasis GO:0055082 215 0.055
regulation of calcium ion transport GO:0051924 69 0.055
positive regulation of secretion by cell GO:1903532 114 0.054
Mouse
lymphocyte mediated immunity GO:0002449 139 0.054
regulation of adaptive immune response GO:0002819 90 0.054
toll like receptor 9 signaling pathway GO:0034162 6 0.054
regulation of reactive oxygen species metabolic process GO:2000377 40 0.054
negative regulation of lymphocyte proliferation GO:0050672 45 0.054
regulation of mapk cascade GO:0043408 248 0.054
Mouse
calcium ion transport into cytosol GO:0060402 48 0.053
negative regulation of adaptive immune response GO:0002820 25 0.053
positive regulation of calcium ion transport into cytosol GO:0010524 9 0.053
negative regulation of cell activation GO:0050866 111 0.051
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.051
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.050
regulation of phagocytosis GO:0050764 33 0.050
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.050
circulatory system process GO:0003013 197 0.049
t helper 17 cell chemotaxis GO:0035705 1 0.049
divalent inorganic cation homeostasis GO:0072507 138 0.049
cellular metal ion homeostasis GO:0006875 151 0.048
negative regulation of lymphocyte activation GO:0051250 91 0.048
negative regulation of phosphorus metabolic process GO:0010563 184 0.048
Mouse
regulation of intracellular transport GO:0032386 159 0.047
positive regulation of cell migration GO:0030335 109 0.046
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.046
Human Mouse
negative regulation of intracellular signal transduction GO:1902532 167 0.045
Mouse
blood circulation GO:0008015 195 0.044
regulation of humoral immune response GO:0002920 22 0.044
regulation of metal ion transport GO:0010959 106 0.044
negative regulation of phosphate metabolic process GO:0045936 184 0.044
Mouse
extracellular matrix organization GO:0030198 147 0.043
cytoplasmic transport GO:0016482 234 0.043
negative regulation of secretion by cell GO:1903531 54 0.042
negative regulation of phagocytosis GO:0050765 4 0.042
organic cyclic compound catabolic process GO:1901361 295 0.041
regulation of t cell activation GO:0050863 170 0.041
b cell proliferation GO:0042100 53 0.041
Mouse
granulocyte chemotaxis GO:0071621 39 0.041
reactive oxygen species metabolic process GO:0072593 84 0.041
positive regulation of protein transport GO:0051222 93 0.041
Mouse
purine containing compound metabolic process GO:0072521 311 0.040
purine ribonucleotide metabolic process GO:0009150 290 0.040
organic anion transport GO:0015711 137 0.040
germ cell development GO:0007281 185 0.040
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.039
small gtpase mediated signal transduction GO:0007264 97 0.039
apoptotic signaling pathway GO:0097190 306 0.039
cell growth GO:0016049 130 0.039
nucleotide metabolic process GO:0009117 332 0.039
regulation of transferase activity GO:0051338 263 0.039
Mouse
antigen receptor mediated signaling pathway GO:0050851 64 0.039
serotonin secretion involved in inflammatory response GO:0002442 4 0.038
cellular response to hormone stimulus GO:0032870 150 0.038
detection of molecule of bacterial origin GO:0032490 2 0.038
positive regulation of calcium ion transport GO:0051928 27 0.038
toll like receptor 7 signaling pathway GO:0034154 4 0.038
anion transport GO:0006820 177 0.038
interleukin 12 production GO:0032615 32 0.038
Mouse
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.038
ameboidal type cell migration GO:0001667 128 0.037
regulation of endocytosis GO:0030100 69 0.037
negative regulation of phosphorylation GO:0042326 166 0.037
Mouse
positive regulation of response to wounding GO:1903036 66 0.037
Mouse
regulation of neuron differentiation GO:0045664 281 0.036
negative regulation of t cell activation GO:0050868 65 0.036
tumor necrosis factor biosynthetic process GO:0042533 10 0.036
Mouse
positive regulation of t cell costimulation GO:2000525 2 0.036
t cell differentiation GO:0030217 174 0.036
sensory perception GO:0007600 245 0.036
axonogenesis GO:0007409 274 0.036
negative regulation of synapse assembly GO:0051964 3 0.036
reactive nitrogen species metabolic process GO:2001057 0 0.036
response to organonitrogen compound GO:0010243 246 0.036
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.036
mapk cascade GO:0000165 281 0.036
Mouse
rho protein signal transduction GO:0007266 32 0.035
macromolecule catabolic process GO:0009057 281 0.035
positive regulation of leukocyte mediated immunity GO:0002705 70 0.035
transmission of nerve impulse GO:0019226 76 0.035
cytosolic calcium ion homeostasis GO:0051480 70 0.034
granulocyte migration GO:0097530 43 0.034
negative regulation of t cell mediated immunity GO:0002710 9 0.033
negative regulation of protein metabolic process GO:0051248 282 0.033
antibacterial peptide biosynthetic process GO:0002780 2 0.033
negative regulation of cellular component organization GO:0051129 194 0.033
positive regulation of cytokine secretion GO:0050715 41 0.032
Mouse
t cell mediated immunity GO:0002456 50 0.032
tumor necrosis factor production GO:0032640 50 0.032
Mouse
mature dendritic cell differentiation GO:0097029 3 0.032
ion transmembrane transport GO:0034220 361 0.032
positive regulation of protein modification process GO:0031401 299 0.031
Mouse
positive regulation of ion transport GO:0043270 65 0.031
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.031
positive regulation of tumor necrosis factor production GO:0032760 30 0.031
Mouse
protein kinase b signaling GO:0043491 74 0.031
negative regulation of cytokine production GO:0001818 84 0.031
Mouse
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.031
regulation of exocytosis GO:0017157 61 0.031
regulation of interleukin 12 production GO:0032655 30 0.030
Mouse
regulation of membrane potential GO:0042391 192 0.030
response to growth factor GO:0070848 198 0.030
positive regulation of t cell activation GO:0050870 101 0.030
myeloid cell activation involved in immune response GO:0002275 34 0.030
leukocyte proliferation GO:0070661 172 0.030
Mouse
exocytosis GO:0006887 121 0.030
regulation of fat cell differentiation GO:0045598 81 0.030
heterocycle catabolic process GO:0046700 280 0.030
negative regulation of homeostatic process GO:0032845 71 0.030
regulation of cellular catabolic process GO:0031329 242 0.030
cell type specific apoptotic process GO:0097285 268 0.029
action potential GO:0001508 78 0.029
positive regulation of interleukin 18 production GO:0032741 2 0.029
Mouse
inorganic ion transmembrane transport GO:0098660 234 0.029
single organismal cell cell adhesion GO:0016337 131 0.029
regulation of kinase activity GO:0043549 249 0.029
Mouse
positive regulation of cell motility GO:2000147 116 0.029
Mouse
transmembrane transport GO:0055085 412 0.029
regulation of immunoglobulin mediated immune response GO:0002889 37 0.029
glycoprotein biosynthetic process GO:0009101 89 0.028
nitrogen compound transport GO:0071705 271 0.028
positive regulation of adaptive immune response GO:0002821 61 0.028
negative regulation of secretion GO:0051048 61 0.028
hematopoietic progenitor cell differentiation GO:0002244 143 0.028
response to lipopolysaccharide GO:0032496 128 0.028
Mouse
positive regulation of stress activated mapk cascade GO:0032874 48 0.028
Mouse
negative regulation of cell proliferation GO:0008285 296 0.027
regulation of lipid metabolic process GO:0019216 118 0.027
posttranscriptional regulation of gene expression GO:0010608 155 0.027
protein catabolic process GO:0030163 221 0.027
cell recognition GO:0008037 83 0.027
organophosphate biosynthetic process GO:0090407 122 0.027
regulation of homeostatic process GO:0032844 182 0.027
regulation of organelle organization GO:0033043 289 0.027
antibacterial peptide production GO:0002778 2 0.027
mast cell activation involved in immune response GO:0002279 20 0.026
negative regulation of eosinophil degranulation GO:0043310 1 0.026
lymphocyte differentiation GO:0030098 242 0.026
cell adhesion GO:0007155 329 0.026
response to peptide hormone GO:0043434 127 0.026
pattern recognition receptor signaling pathway GO:0002221 47 0.026
Mouse
positive regulation of vasoconstriction GO:0045907 4 0.026
skeletal system development GO:0001501 356 0.026
regulation of monocyte chemotaxis GO:0090025 3 0.026
cellular response to growth factor stimulus GO:0071363 197 0.026
gliogenesis GO:0042063 141 0.025
detection of stimulus GO:0051606 84 0.025
positive regulation of intracellular transport GO:0032388 70 0.025
positive regulation of endocytosis GO:0045807 42 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.025
positive regulation of lymphocyte proliferation GO:0050671 70 0.025
Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.025
positive regulation of t cell extravasation GO:2000409 2 0.025
activation of mapk activity involved in innate immune response GO:0035419 2 0.025
response to acid chemical GO:0001101 111 0.025
negative regulation of regulated secretory pathway GO:1903306 7 0.025
aromatic compound catabolic process GO:0019439 286 0.025
regulation of cell cycle GO:0051726 281 0.025
nucleoside phosphate metabolic process GO:0006753 338 0.024
protein processing GO:0016485 163 0.024
interferon beta biosynthetic process GO:0045350 4 0.024
Human Mouse
response to organic cyclic compound GO:0014070 198 0.024
regulation of t cell mediated immunity GO:0002709 34 0.024
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.024
regulation of immunological synapse formation GO:2000520 2 0.024
multicellular organismal signaling GO:0035637 91 0.024
peptidyl tyrosine phosphorylation GO:0018108 143 0.024
positive regulation of cell death GO:0010942 224 0.024
positive regulation of map kinase activity GO:0043406 84 0.024
Mouse
carbohydrate metabolic process GO:0005975 230 0.024
ras protein signal transduction GO:0007265 77 0.024
cellular macromolecule catabolic process GO:0044265 206 0.024
regulation of protein kinase b signaling GO:0051896 56 0.024
defense response to virus GO:0051607 68 0.024
Human
helper t cell chemotaxis GO:0035704 1 0.024
mast cell activation GO:0045576 27 0.024
negative regulation of response to wounding GO:1903035 77 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.024
organic hydroxy compound transport GO:0015850 93 0.023
inorganic cation transmembrane transport GO:0098662 207 0.023
monocyte extravasation GO:0035696 2 0.023
response to peptide GO:1901652 136 0.023
regulation of interferon gamma production GO:0032649 57 0.023
Human Mouse
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.023
Mouse
b cell activation GO:0042113 161 0.023
Mouse
glycosyl compound catabolic process GO:1901658 206 0.023
regulation of vascular endothelial growth factor production GO:0010574 13 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.023
regulation of mast cell activation GO:0033003 21 0.023
positive regulation of nervous system development GO:0051962 221 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
positive regulation vascular endothelial growth factor production GO:0010575 10 0.023
protein modification by small protein conjugation or removal GO:0070647 207 0.023
regulation of interleukin 6 production GO:0032675 55 0.023
Mouse
cartilage development GO:0051216 140 0.022
regulation of hormone levels GO:0010817 211 0.022
digestive system development GO:0055123 200 0.022
t cell extravasation GO:0072683 4 0.022
regulation of protein kinase activity GO:0045859 232 0.022
Mouse
digestive tract development GO:0048565 190 0.022
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.022
positive regulation of secretion GO:0051047 130 0.022
Mouse
response to oxidative stress GO:0006979 123 0.022
carboxylic acid transport GO:0046942 100 0.022
positive regulation of gliogenesis GO:0014015 27 0.022
positive regulation of nucleoside metabolic process GO:0045979 91 0.022
neuronal action potential GO:0019228 54 0.022
regulation of apoptotic signaling pathway GO:2001233 197 0.022
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
Mouse
regulation of b cell proliferation GO:0030888 39 0.021
Mouse
regulation of t cell costimulation GO:2000523 2 0.021
stem cell differentiation GO:0048863 268 0.021
microglial cell activation involved in immune response GO:0002282 1 0.021
myeloid leukocyte activation GO:0002274 83 0.021
positive regulation of interleukin 8 production GO:0032757 2 0.021
Human
stress activated protein kinase signaling cascade GO:0031098 81 0.021
Mouse
dna metabolic process GO:0006259 303 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.021
lipid biosynthetic process GO:0008610 179 0.021
regulation of hematopoietic stem cell migration GO:2000471 1 0.021
regulation of leukocyte differentiation GO:1902105 159 0.021
regulation of natural killer cell activation GO:0032814 22 0.021
regulation of protein processing GO:0070613 96 0.020
negative regulation of intracellular transport GO:0032387 38 0.020
regulation of neutrophil chemotaxis GO:0090022 14 0.020
protein maturation GO:0051604 176 0.020
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.020
cellular amide metabolic process GO:0043603 58 0.020
b cell activation involved in immune response GO:0002312 50 0.020
Mouse
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.020
hormone secretion GO:0046879 128 0.020
cellular lipid metabolic process GO:0044255 323 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
interspecies interaction between organisms GO:0044419 83 0.020
Mouse
neutrophil migration GO:1990266 37 0.020
regulation of rho protein signal transduction GO:0035023 71 0.020
eosinophil activation involved in immune response GO:0002278 1 0.020
intracellular protein transport GO:0006886 204 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
myeloid leukocyte mediated immunity GO:0002444 42 0.020
production of molecular mediator of immune response GO:0002440 103 0.020
Mouse
regulation of acute inflammatory response GO:0002673 27 0.020
negative regulation of protein modification process GO:0031400 163 0.020
antimicrobial peptide production GO:0002775 2 0.020
cellular response to oxidative stress GO:0034599 76 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.019
neuron apoptotic process GO:0051402 142 0.019
positive regulation of cytoplasmic transport GO:1903651 40 0.019
negative regulation of defense response GO:0031348 77 0.019
myelination GO:0042552 74 0.019
immune complex clearance GO:0002434 2 0.019
regulation of proteolysis GO:0030162 164 0.019
positive regulation of leukocyte differentiation GO:1902107 86 0.019
extracellular structure organization GO:0043062 148 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
Mouse
cognition GO:0050890 149 0.019
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.019
negative regulation of cellular amine metabolic process GO:0033239 1 0.019
organophosphate catabolic process GO:0046434 232 0.019
gland development GO:0048732 330 0.019
glucan metabolic process GO:0044042 32 0.019
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.019
positive regulation of cell development GO:0010720 237 0.018
toll like receptor signaling pathway GO:0002224 38 0.018
Mouse
interleukin 18 production GO:0032621 4 0.018
Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.018
vasoconstriction GO:0042310 27 0.018
generation of precursor metabolites and energy GO:0006091 103 0.018
negative regulation of leukocyte degranulation GO:0043301 7 0.018
b cell differentiation GO:0030183 78 0.018
regulation of gliogenesis GO:0014013 50 0.018
serotonin production involved in inflammatory response GO:0002351 4 0.018
energy derivation by oxidation of organic compounds GO:0015980 77 0.018
vascular endothelial growth factor production GO:0010573 13 0.018
cellular nitrogen compound catabolic process GO:0044270 280 0.018
positive regulation of monocyte extravasation GO:2000439 1 0.018
heart process GO:0003015 94 0.018
macrophage chemotaxis GO:0048246 14 0.018
anatomical structure homeostasis GO:0060249 145 0.018
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
cellular carbohydrate metabolic process GO:0044262 119 0.018
regulation of neuron death GO:1901214 134 0.018
cellular response to peptide hormone stimulus GO:0071375 92 0.018
connective tissue development GO:0061448 179 0.017
eosinophil mediated immunity GO:0002447 1 0.017
cation transmembrane transport GO:0098655 266 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
Mouse
organic acid transport GO:0015849 101 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
peptide metabolic process GO:0006518 46 0.017
ensheathment of neurons GO:0007272 76 0.017
epithelial cell migration GO:0010631 63 0.017
vascular process in circulatory system GO:0003018 62 0.017
cell substrate adhesion GO:0031589 130 0.017
regulation of map kinase activity GO:0043405 120 0.017
Mouse
purine ribonucleotide catabolic process GO:0009154 208 0.017
detection of peptidoglycan GO:0032499 1 0.017
kidney development GO:0001822 213 0.017
lipopolysaccharide metabolic process GO:0008653 2 0.017
positive regulation of interferon alpha production GO:0032727 4 0.017
Human Mouse
glucose homeostasis GO:0042593 128 0.017
immunoglobulin mediated immune response GO:0016064 69 0.017
epithelium migration GO:0090132 63 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.016
signal transduction in absence of ligand GO:0038034 55 0.016
regulation of b cell mediated immunity GO:0002712 37 0.016
cellular response to peptidoglycan GO:0071224 4 0.016
Mouse
organelle assembly GO:0070925 177 0.016
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
positive regulation of glial cell differentiation GO:0045687 21 0.016
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.016
inositol lipid mediated signaling GO:0048017 41 0.016
body fluid secretion GO:0007589 53 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.016
Mouse
purinergic nucleotide receptor signaling pathway GO:0035590 3 0.016
transepithelial chloride transport GO:0030321 4 0.016
epithelial cell proliferation GO:0050673 174 0.016
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.016
epidermis development GO:0008544 187 0.016
regulation of calcium mediated signaling GO:0050848 19 0.016
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.016
striated muscle tissue development GO:0014706 293 0.016
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.016
Mouse
reactive oxygen species biosynthetic process GO:1903409 8 0.016
response to molecule of fungal origin GO:0002238 4 0.016
Mouse
muscle cell differentiation GO:0042692 261 0.016
cellular response to peptide GO:1901653 92 0.016
positive regulation of immunological synapse formation GO:2000522 1 0.016
cellular response to lipid GO:0071396 145 0.016
Mouse
response to yeast GO:0001878 6 0.016
regulation of monocyte extravasation GO:2000437 2 0.015

Tlr8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
acquired immunodeficiency syndrome DOID:635 0 0.050
disease by infectious agent DOID:0050117 0 0.050
viral infectious disease DOID:934 0 0.050
human immunodeficiency virus infectious disease DOID:526 0 0.050
immune system disease DOID:2914 0 0.030
disease of anatomical entity DOID:7 0 0.030
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
organ system cancer DOID:0050686 0 0.026
nervous system disease DOID:863 0 0.023
disease of metabolism DOID:0014667 0 0.020
sensory system disease DOID:0050155 0 0.018
eye and adnexa disease DOID:1492 0 0.018
eye disease DOID:5614 0 0.018