|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
1.000
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
1.000
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.999
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.998
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.997
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.995
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.994
|
|
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
0.993
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.991
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.989
|
|
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.985
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.985
|
Human |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.984
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.982
|
Human |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.980
|
Human |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.978
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.978
|
Human |
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.974
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.973
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.973
|
|
|
|
positive regulation of t helper 1 cell differentiation
|
GO:0045627 |
4 |
0.969
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.967
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.967
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.967
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.967
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.967
|
Human |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.966
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.966
|
|
|
|
alpha beta t cell activation involved in immune response
|
GO:0002287 |
31 |
0.965
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.961
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.958
|
|
|
|
regulation of cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:2000452 |
2 |
0.957
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.956
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.953
|
Human |
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.951
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.950
|
|
|
|
t helper cell differentiation
|
GO:0042093 |
28 |
0.949
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.949
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.946
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.943
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.941
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.940
|
|
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.939
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.938
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.933
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.931
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.930
|
Human |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.929
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.929
|
|
|
|
response to interleukin 12
|
GO:0070671 |
2 |
0.929
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.926
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.924
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.923
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.922
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.921
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.914
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.912
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.911
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.911
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.911
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
0.910
|
|
|
|
nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070427 |
5 |
0.906
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.906
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.903
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.902
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.901
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.901
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.900
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.900
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.895
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.894
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.893
|
Human |
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
4 |
0.893
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.893
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.891
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.883
|
|
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.882
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.876
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.875
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.873
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.873
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.872
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.871
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.871
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.871
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.869
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.868
|
|
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.866
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.854
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.852
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.851
|
Human |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.849
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.849
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.848
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
34 |
0.845
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.841
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.838
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
28 |
0.834
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
55 |
0.833
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.831
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.829
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.827
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.827
|
Human |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.825
|
Human |
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.819
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.818
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.815
|
Human |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.813
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.813
|
|
|
|
toll like receptor 4 signaling pathway
|
GO:0034142 |
9 |
0.812
|
|
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
16 |
0.809
|
|
|
|
regulation of cd4 positive alpha beta t cell activation
|
GO:2000514 |
24 |
0.799
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.793
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.791
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.777
|
Human |
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.773
|
|
|
|
t cell differentiation involved in immune response
|
GO:0002292 |
30 |
0.768
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.766
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.764
|
Human |
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.760
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.756
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.750
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.750
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.749
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.748
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.747
|
|
|
|
regulation of t helper cell differentiation
|
GO:0045622 |
14 |
0.744
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.733
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.730
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.729
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.728
|
Human |
|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.728
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.724
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.715
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.709
|
|
|
|
cellular response to nitric oxide
|
GO:0071732 |
4 |
0.707
|
|
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.706
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.705
|
|
|
|
cd4 positive alpha beta t cell cytokine production
|
GO:0035743 |
4 |
0.702
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.699
|
|
|
|
regulation of interleukin 5 secretion
|
GO:2000662 |
2 |
0.698
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.693
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.691
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.687
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.684
|
|
|
|
t cell apoptotic process
|
GO:0070231 |
39 |
0.679
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.667
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
5 |
0.663
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.663
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.658
|
|
|
|
type i interferon production
|
GO:0032606 |
29 |
0.657
|
|
|
|
regulation of interleukin 13 secretion
|
GO:2000665 |
2 |
0.655
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.655
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.653
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.653
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.648
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.648
|
|
|
|
spleen development
|
GO:0048536 |
39 |
0.648
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.648
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.644
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.643
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.642
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.631
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.631
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.628
|
Human |
|
|
positive regulation of interleukin 12 production
|
GO:0032735 |
21 |
0.627
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.623
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.619
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.617
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.609
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.604
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
17 |
0.601
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.599
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.596
|
Human |
|
|
myd88 independent toll like receptor signaling pathway
|
GO:0002756 |
3 |
0.594
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.588
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.585
|
|
|
|
interleukin 12 production
|
GO:0032615 |
32 |
0.581
|
|
|
|
regulation of t helper 1 cell differentiation
|
GO:0045625 |
7 |
0.574
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.570
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.562
|
|
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
11 |
0.559
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.558
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.545
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.544
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.540
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.536
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.533
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.532
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.528
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
1 |
0.527
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.520
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.508
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.508
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.508
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.508
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.505
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.500
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.496
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.490
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.488
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.486
|
|
|
|
positive regulation of cd4 positive alpha beta t cell activation
|
GO:2000516 |
16 |
0.484
|
|
|
|
t helper 2 cell cytokine production
|
GO:0035745 |
4 |
0.481
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
83 |
0.477
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
19 |
0.472
|
|
|
|
positive regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031666 |
5 |
0.469
|
|
|
|
positive regulation of t helper cell differentiation
|
GO:0045624 |
9 |
0.468
|
|
|
|
cd4 positive or cd8 positive alpha beta t cell lineage commitment
|
GO:0043369 |
8 |
0.467
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.467
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
3 |
0.466
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.465
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.458
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.456
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.454
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.447
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.440
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.437
|
|
|
|
t helper 1 type immune response
|
GO:0042088 |
25 |
0.433
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
25 |
0.431
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.429
|
Human |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.427
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.413
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.413
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.410
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.406
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.404
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.403
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.401
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.399
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
81 |
0.397
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.397
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.396
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.394
|
|
|
|
t cell homeostasis
|
GO:0043029 |
35 |
0.392
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.386
|
Human |
|
|
myd88 dependent toll like receptor signaling pathway
|
GO:0002755 |
7 |
0.383
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
57 |
0.382
|
|
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
39 |
0.381
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
48 |
0.381
|
|
|
|
response to dsrna
|
GO:0043331 |
30 |
0.376
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.373
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
11 |
0.372
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
37 |
0.371
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.366
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.366
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.363
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
61 |
0.359
|
|
|
|
macrophage differentiation
|
GO:0030225 |
20 |
0.356
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.356
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.353
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.353
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
23 |
0.347
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.347
|
|
|
|
antigen processing and presentation of peptide antigen via mhc class ii
|
GO:0002495 |
17 |
0.344
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.341
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
41 |
0.337
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
24 |
0.337
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.336
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.336
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.335
|
|
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.334
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.331
|
|
|
|
interleukin 13 secretion
|
GO:0072611 |
2 |
0.331
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.330
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.329
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.328
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.328
|
|
|
|
regulation of cell killing
|
GO:0031341 |
40 |
0.327
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.326
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.325
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.323
|
|
|
|
regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043370 |
21 |
0.323
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.322
|
|
|
|
b cell proliferation
|
GO:0042100 |
53 |
0.320
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.319
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.318
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.318
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.315
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.315
|
|
|
|
interleukin 12 biosynthetic process
|
GO:0042090 |
8 |
0.313
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.312
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.308
|
|
|
|
histone modification
|
GO:0016570 |
159 |
0.308
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.307
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.303
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.297
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.296
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.296
|
|
|
|
interferon gamma production
|
GO:0032609 |
67 |
0.294
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.292
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.291
|
|
|
|
cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:0035698 |
2 |
0.291
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.291
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.289
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.288
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.288
|
|
|
|
regulation of t cell extravasation
|
GO:2000407 |
3 |
0.276
|
|
|
|
positive regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902110 |
11 |
0.275
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
83 |
0.274
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.269
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.269
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.268
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
21 |
0.265
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
56 |
0.265
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.259
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.258
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.258
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
13 |
0.250
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.250
|
|
|
|
wound healing
|
GO:0042060 |
157 |
0.248
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.245
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.242
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.241
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.239
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.238
|
|
|
|
mitochondrial outer membrane permeabilization involved in programmed cell death
|
GO:1902686 |
11 |
0.237
|
|
|
|
regulation of interleukin 12 biosynthetic process
|
GO:0045075 |
8 |
0.237
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.236
|
|
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
39 |
0.235
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.235
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.234
|
Human |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.232
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.232
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.226
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.226
|
|
|
|
modification of morphology or physiology of other organism involved in symbiotic interaction
|
GO:0051817 |
16 |
0.226
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.224
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.224
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
26 |
0.222
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.221
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.221
|
|
|
|
regulation of antimicrobial peptide production
|
GO:0002784 |
1 |
0.220
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
74 |
0.219
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.217
|
|
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
2 |
0.217
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.217
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.216
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.216
|
|
|
|
regulation of myd88 independent toll like receptor signaling pathway
|
GO:0034127 |
1 |
0.216
|
|
|
|
odontogenesis of dentin containing tooth
|
GO:0042475 |
66 |
0.215
|
|
|
|
response to amino acid
|
GO:0043200 |
37 |
0.215
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.213
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
30 |
0.212
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
49 |
0.209
|
|
|
|
regulation of t cell mediated cytotoxicity
|
GO:0001914 |
18 |
0.209
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.206
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
26 |
0.205
|
|
|
|
t cell extravasation
|
GO:0072683 |
4 |
0.203
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
22 |
0.202
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.202
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.202
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
46 |
0.202
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
6 |
0.202
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.200
|
|
|
|
tube formation
|
GO:0035148 |
140 |
0.195
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.194
|
|
|
|
bone resorption
|
GO:0045453 |
38 |
0.193
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.192
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
96 |
0.192
|
|
|
|
regulation of protein deacetylation
|
GO:0090311 |
17 |
0.190
|
|
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.189
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.189
|
|
|
|
negative regulation of t helper 2 cell differentiation
|
GO:0045629 |
4 |
0.187
|
|
|
|
negative regulation of regulatory t cell differentiation
|
GO:0045590 |
2 |
0.185
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.185
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.185
|
|
|
|
t helper 2 cell differentiation
|
GO:0045064 |
12 |
0.184
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.184
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.182
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.182
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.179
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.178
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.178
|
|
|
|
t cell migration
|
GO:0072678 |
19 |
0.177
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.175
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.174
|
|
|
|
tube closure
|
GO:0060606 |
91 |
0.173
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
15 |
0.172
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.165
|
|
|
|
protein homooligomerization
|
GO:0051260 |
43 |
0.165
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.165
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
1 |
0.164
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.163
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.162
|
|
|
|
lymphocyte migration
|
GO:0072676 |
26 |
0.162
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
27 |
0.160
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
2 |
0.160
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
6 |
0.160
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.159
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.159
|
|
|
|
positive regulation of interleukin 6 biosynthetic process
|
GO:0045410 |
6 |
0.159
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.159
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
50 |
0.158
|
|
|
|
dephosphorylation
|
GO:0016311 |
129 |
0.155
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.155
|
|
|
|
protein homotrimerization
|
GO:0070207 |
4 |
0.155
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
33 |
0.154
|
Human |
|
|
positive regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043372 |
14 |
0.154
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.153
|
|
|
|
modification by symbiont of host morphology or physiology
|
GO:0044003 |
4 |
0.153
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.152
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:0097296 |
2 |
0.151
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.149
|
|
|
|
t helper 17 cell lineage commitment
|
GO:0072540 |
4 |
0.149
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.148
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.147
|
|
|
|
negative regulation of t cell differentiation
|
GO:0045581 |
23 |
0.144
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.143
|
|
|
|
regulation of immunoglobulin secretion
|
GO:0051023 |
12 |
0.143
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.142
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.141
|
Human |
|
|
regulation of t helper 2 cell cytokine production
|
GO:2000551 |
3 |
0.141
|
|
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
28 |
0.141
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.140
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.140
|
|
|
|
regulation of activated t cell proliferation
|
GO:0046006 |
16 |
0.140
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.140
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.138
|
|
|
|
interleukin 8 production
|
GO:0032637 |
4 |
0.137
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.136
|
|
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.136
|
|
|
|
regulation of anion transport
|
GO:0044070 |
27 |
0.135
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.135
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.135
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.135
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.134
|
Human |
|
|
response to drug
|
GO:0042493 |
75 |
0.133
|
|
|
|
leukocyte cell cell adhesion
|
GO:0007159 |
14 |
0.132
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.132
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.131
|
|
|
|
dendritic cell differentiation
|
GO:0097028 |
26 |
0.131
|
|
|
|
interferon beta production
|
GO:0032608 |
16 |
0.130
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.129
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.129
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.128
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.128
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.127
|
|
|
|
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii
|
GO:0002504 |
17 |
0.127
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.125
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
52 |
0.125
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.124
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.122
|
|
|
|
modification of morphology or physiology of other organism
|
GO:0035821 |
18 |
0.122
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.121
|
|
|
|
protein deacylation
|
GO:0035601 |
36 |
0.121
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
81 |
0.120
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.120
|
|
|
|
positive t cell selection
|
GO:0043368 |
23 |
0.120
|
|
|
|
regulation of protein homodimerization activity
|
GO:0043496 |
4 |
0.119
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.119
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
116 |
0.118
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.118
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.117
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.116
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
71 |
0.116
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.114
|
|
|
|
t cell cytokine production
|
GO:0002369 |
10 |
0.114
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.114
|
|
|
|
extracellular matrix organization
|
GO:0030198 |
147 |
0.114
|
|
|
|
regulation of homotypic cell cell adhesion
|
GO:0034110 |
13 |
0.113
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
4 |
0.113
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
57 |
0.111
|
|
|
|
regulation of chemokine production
|
GO:0032642 |
30 |
0.111
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
79 |
0.111
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.111
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.110
|
|
|
|
thymus development
|
GO:0048538 |
41 |
0.110
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
3 |
0.110
|
|
|
|
organic acid transport
|
GO:0015849 |
101 |
0.110
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.110
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.109
|
|
|
|
labyrinthine layer development
|
GO:0060711 |
49 |
0.109
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.109
|
|
|
|
immature t cell proliferation
|
GO:0033079 |
8 |
0.109
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.108
|
|
|
|
defense response to protozoan
|
GO:0042832 |
25 |
0.108
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
82 |
0.108
|
|
|
|
negative regulation of interleukin 5 secretion
|
GO:2000663 |
1 |
0.108
|
|
|
|
positive regulation of b cell activation
|
GO:0050871 |
49 |
0.106
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.106
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
77 |
0.106
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
56 |
0.106
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.104
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.104
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.103
|
|
|
|
rna 3 end processing
|
GO:0031123 |
20 |
0.103
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
64 |
0.103
|
|
|
|
eye photoreceptor cell differentiation
|
GO:0001754 |
41 |
0.103
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
35 |
0.102
|
|
|
|
germinal center formation
|
GO:0002467 |
16 |
0.102
|
|
|
|
response to protozoan
|
GO:0001562 |
28 |
0.101
|
|
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
4 |
0.101
|
|
