Mus musculus

329 known processes

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

(Aliases: Trance,Ly109l,OPG,RANKL,OPGL,ODF)

Tnfsf11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
interleukin 10 secretion GO:0072608 4 0.995
regulation of interleukin 10 secretion GO:2001179 4 0.984
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.977
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.942
Mouse
lymph node development GO:0048535 18 0.935
Mouse
gland development GO:0048732 330 0.916
positive regulation of inflammatory response GO:0050729 47 0.902
regulation of acute inflammatory response GO:0002673 27 0.899
metal ion homeostasis GO:0055065 189 0.898
tissue remodeling GO:0048771 102 0.889
interleukin 5 secretion GO:0072603 2 0.877
positive regulation of translational initiation GO:0045948 4 0.869
Mouse
epithelial cell proliferation GO:0050673 174 0.849
regulation of leukocyte proliferation GO:0070663 121 0.849
myeloid leukocyte differentiation GO:0002573 119 0.847
innate immune response GO:0045087 157 0.842
Fly
chemotaxis GO:0006935 247 0.833
Human Mouse
extracellular structure organization GO:0043062 148 0.831
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.828
Mouse Fly
positive regulation of cell activation GO:0050867 158 0.818
Human Mouse
somatic diversification of immunoglobulins GO:0016445 43 0.807
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.804
Mouse
fever generation GO:0001660 7 0.799
leukocyte differentiation GO:0002521 342 0.796
cellular amino acid metabolic process GO:0006520 103 0.790
negative regulation of interleukin 10 secretion GO:2001180 2 0.789
icosanoid secretion GO:0032309 12 0.788
ossification GO:0001503 216 0.777
dna recombination GO:0006310 92 0.777
Mouse
extracellular matrix organization GO:0030198 147 0.766
Mouse
odontogenesis GO:0042476 78 0.764
positive regulation of lymphocyte proliferation GO:0050671 70 0.757
glial cell differentiation GO:0010001 131 0.751
multicellular organismal homeostasis GO:0048871 164 0.749
mammary gland alveolus development GO:0060749 22 0.743
cellular response to amino acid stimulus GO:0071230 29 0.734
Mouse
positive regulation of lipid transport GO:0032370 22 0.709
osteoclast differentiation GO:0030316 62 0.696
positive regulation of cytokine production GO:0001819 174 0.695
Mouse
regulation of organ morphogenesis GO:2000027 144 0.695
Mouse
corticotropin releasing hormone secretion GO:0043396 2 0.693
myeloid cell differentiation GO:0030099 233 0.685
t cell migration GO:0072678 19 0.682
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.679
Mouse
regulation of fatty acid transport GO:2000191 10 0.677
branching morphogenesis of an epithelial tube GO:0048754 159 0.676
morphogenesis of a branching structure GO:0001763 203 0.673
Mouse
defense response to other organism GO:0098542 197 0.672
Mouse Fly
acid secretion GO:0046717 33 0.669
temperature homeostasis GO:0001659 26 0.667
epithelial tube morphogenesis GO:0060562 303 0.661
positive regulation of leukocyte proliferation GO:0070665 73 0.660
sensory organ morphogenesis GO:0090596 242 0.657
Mouse
positive regulation of interleukin 12 production GO:0032735 21 0.657
lipid localization GO:0010876 126 0.653
monocarboxylic acid transport GO:0015718 44 0.649
regulation of b cell proliferation GO:0030888 39 0.641
dna metabolic process GO:0006259 303 0.629
Mouse
positive regulation of fever generation GO:0031622 6 0.624
regulation of protein localization GO:0032880 231 0.620
Mouse
regulation of protein transport GO:0051223 163 0.616
Mouse
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.610
Mouse
t cell activation GO:0042110 289 0.610
Human Mouse
regulation of jun kinase activity GO:0043506 40 0.607
calcium ion homeostasis GO:0055074 127 0.605
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.599
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.593
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.593
dendritic cell differentiation GO:0097028 26 0.575
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.565
Mouse
positive regulation of organic acid transport GO:0032892 11 0.561
regulation of lymphocyte mediated immunity GO:0002706 84 0.560
Mouse
organic acid transport GO:0015849 101 0.557
inflammatory response GO:0006954 244 0.557
acute inflammatory response GO:0002526 41 0.556
regulation of cytokine production GO:0001817 266 0.549
Mouse
fatty acid transport GO:0015908 28 0.548
response to organonitrogen compound GO:0010243 246 0.546
Mouse
positive regulation of cell motility GO:2000147 116 0.545
Mouse
regulation of organic acid transport GO:0032890 16 0.541
interleukin 13 secretion GO:0072611 2 0.537
b cell mediated immunity GO:0019724 71 0.535
Mouse
carboxylic acid transport GO:0046942 100 0.530
gliogenesis GO:0042063 141 0.519
positive regulation of defense response GO:0031349 124 0.517
positive regulation of icosanoid secretion GO:0032305 7 0.516
positive regulation of innate immune response GO:0045089 80 0.513
cytokine production GO:0001816 319 0.512
Mouse
cellular amine metabolic process GO:0044106 44 0.512
cellular response to biotic stimulus GO:0071216 92 0.510
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.508
regulation of cytokine secretion involved in immune response GO:0002739 4 0.494
positive regulation of chronic inflammatory response GO:0002678 4 0.494
Mouse
cellular calcium ion homeostasis GO:0006874 119 0.491
positive regulation of translational initiation by iron GO:0045994 2 0.485
Mouse
negative regulation of growth GO:0045926 99 0.484
Mouse
somatic diversification of immune receptors GO:0002200 53 0.480
Mouse
organic anion transport GO:0015711 137 0.480
regulation of gliogenesis GO:0014013 50 0.477
negative regulation of interleukin 5 production GO:0032714 4 0.470
cell chemotaxis GO:0060326 81 0.469
Human Mouse
fatty acid derivative transport GO:1901571 14 0.468
cellular homeostasis GO:0019725 240 0.466
Fly
regulation of anion transport GO:0044070 27 0.463
regulation of leukocyte mediated immunity GO:0002703 104 0.458
Mouse
amine metabolic process GO:0009308 45 0.457
leukocyte migration GO:0050900 124 0.451
Human Mouse
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.450
forebrain cell migration GO:0021885 58 0.448
regulation of immunoglobulin production GO:0002637 42 0.443
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.441
cation homeostasis GO:0055080 212 0.441
positive regulation of jun kinase activity GO:0043507 30 0.439
cytokine mediated signaling pathway GO:0019221 115 0.436
regulation of prostaglandin secretion GO:0032306 5 0.434
positive regulation of apoptotic process GO:0043065 217 0.434
Mouse
mammary gland lobule development GO:0061377 22 0.432
regulation of hydrolase activity GO:0051336 246 0.431
Mouse
hair cycle GO:0042633 90 0.424
Mouse
cellular response to tumor necrosis factor GO:0071356 21 0.423
cellular chemical homeostasis GO:0055082 215 0.417
regulation of interleukin 13 secretion GO:2000665 2 0.416
t cell differentiation GO:0030217 174 0.414
positive regulation of fatty acid transport GO:2000193 8 0.413
regulation of jnk cascade GO:0046328 62 0.411
regulation of cytokine secretion GO:0050707 61 0.408
cellular response to organonitrogen compound GO:0071417 145 0.403
Mouse
negative regulation of cell proliferation GO:0008285 296 0.401
calcium ion transport GO:0006816 159 0.400
defense response to gram negative bacterium GO:0050829 28 0.398
Fly
regulation of t cell activation GO:0050863 170 0.396
Human Mouse
humoral immune response GO:0006959 57 0.392
Mouse
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.392
Mouse
telencephalon development GO:0021537 186 0.390
positive regulation of prostaglandin secretion GO:0032308 5 0.390
positive regulation of interferon gamma production GO:0032729 39 0.389
Mouse
cellular response to molecule of bacterial origin GO:0071219 83 0.386
Mouse
circadian rhythm GO:0007623 114 0.386
regulation of cell activation GO:0050865 289 0.385
Human Mouse
protein kinase b signaling GO:0043491 74 0.384
immunoglobulin mediated immune response GO:0016064 69 0.381
Mouse
response to molecule of bacterial origin GO:0002237 143 0.381
Mouse
skeletal system development GO:0001501 356 0.378
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.378
Mouse
lymphocyte proliferation GO:0046651 164 0.377
regulation of myeloid cell differentiation GO:0045637 96 0.375
positive regulation of leukocyte differentiation GO:1902107 86 0.374
odontogenesis of dentin containing tooth GO:0042475 66 0.373
cellular response to lipopolysaccharide GO:0071222 77 0.372
Mouse
negative regulation of interleukin 13 secretion GO:2000666 1 0.369
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.364
regulation of peptide secretion GO:0002791 77 0.363
positive regulation of adaptive immune response GO:0002821 61 0.360
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.357
b cell activation GO:0042113 161 0.356
Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.356
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.355
anion transport GO:0006820 177 0.348
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.347
hair follicle development GO:0001942 85 0.341
Mouse
immunoglobulin secretion GO:0048305 17 0.339
Mouse
lipid transport GO:0006869 98 0.333
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.332
Mouse
t cell proliferation GO:0042098 120 0.330
cellular ion homeostasis GO:0006873 165 0.329
mammary gland epithelium development GO:0061180 65 0.327
regulation of odontogenesis GO:0042481 18 0.326
apoptotic signaling pathway GO:0097190 306 0.322
Mouse Fly
b cell activation involved in immune response GO:0002312 50 0.321
Mouse
positive regulation of osteoclast differentiation GO:0045672 15 0.320
regulation of peptide hormone secretion GO:0090276 75 0.320
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.317
regionalization GO:0003002 337 0.316
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.313
adaptive immune response GO:0002250 155 0.312
Mouse
isotype switching GO:0045190 36 0.312
Mouse
leukocyte mediated immunity GO:0002443 174 0.310
Mouse
positive regulation of heat generation GO:0031652 7 0.309
axon ensheathment GO:0008366 76 0.308
negative regulation of odontogenesis of dentin containing tooth GO:0042489 1 0.307
posttranscriptional regulation of gene expression GO:0010608 155 0.307
Mouse
somatic cell dna recombination GO:0016444 51 0.306
Mouse
regulation of secretion by cell GO:1903530 249 0.305
positive regulation of protein phosphorylation GO:0001934 242 0.303
t cell differentiation in thymus GO:0033077 77 0.301
blood vessel morphogenesis GO:0048514 285 0.300
regulation of morphogenesis of a branching structure GO:0060688 53 0.300
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.299
cytokine production involved in immune response GO:0002367 34 0.295
lymphocyte mediated immunity GO:0002449 139 0.292
Mouse
cellular response to acid chemical GO:0071229 68 0.290
Mouse
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.289
regulation of protein kinase activity GO:0045859 232 0.287
regulation of interleukin 5 secretion GO:2000662 2 0.286
ameboidal type cell migration GO:0001667 128 0.285
regulation of fever generation by regulation of prostaglandin secretion GO:0071810 2 0.284
cellular response to dna damage stimulus GO:0006974 207 0.282
Mouse
inflammatory response to antigenic stimulus GO:0002437 30 0.275
Mouse
regulation of icosanoid secretion GO:0032303 8 0.275
skeletal system morphogenesis GO:0048705 203 0.272
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.272
Mouse
regulation of defense response GO:0031347 233 0.271
regulation of lymphocyte proliferation GO:0050670 117 0.269
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.267
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.266
lymphocyte migration GO:0072676 26 0.265
Mouse
sensory perception GO:0007600 245 0.265
icosanoid transport GO:0071715 14 0.265
stem cell development GO:0048864 219 0.263
cellular divalent inorganic cation homeostasis GO:0072503 127 0.260
defense response to bacterium GO:0042742 119 0.260
Mouse Fly
reactive oxygen species metabolic process GO:0072593 84 0.258
Mouse
cell fate commitment GO:0045165 210 0.255
Fly
cytokine secretion involved in immune response GO:0002374 6 0.255
peptide secretion GO:0002790 114 0.255
regulation of cellular ketone metabolic process GO:0010565 66 0.249
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.247
positive regulation of lymphocyte activation GO:0051251 140 0.247
Human Mouse
pallium development GO:0021543 120 0.246
b cell differentiation GO:0030183 78 0.245
Mouse
peptidyl amino acid modification GO:0018193 336 0.245
regulation of oligodendrocyte differentiation GO:0048713 23 0.245
regulation of cysteine type endopeptidase activity GO:2000116 65 0.244
Mouse
positive regulation of ion transport GO:0043270 65 0.242
muscle tissue development GO:0060537 308 0.242
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.241
reactive nitrogen species metabolic process GO:2001057 0 0.239
regulation of secretion GO:0051046 274 0.238
heat generation GO:0031649 13 0.238
ensheathment of neurons GO:0007272 76 0.238
cellular ketone metabolic process GO:0042180 84 0.237
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.234
Mouse
regulation of t cell proliferation GO:0042129 92 0.232
epidermis development GO:0008544 187 0.231
Mouse
transmission of nerve impulse GO:0019226 76 0.230
intrinsic apoptotic signaling pathway GO:0097193 132 0.229
Mouse
myeloid dendritic cell differentiation GO:0043011 16 0.228
immune effector process GO:0002252 321 0.227
Mouse
antibacterial peptide production GO:0002778 2 0.227
lymphocyte differentiation GO:0030098 242 0.225
Mouse
negative regulation of interleukin 5 secretion GO:2000663 1 0.225
mapk cascade GO:0000165 281 0.224
rhythmic process GO:0048511 174 0.223
regulation of b cell activation GO:0050864 81 0.223
positive regulation of protein transport GO:0051222 93 0.223
Mouse
mesenchyme development GO:0060485 152 0.221
positive regulation of mapk cascade GO:0043410 170 0.221
production of molecular mediator of immune response GO:0002440 103 0.221
Mouse
myeloid dendritic cell activation GO:0001773 25 0.220
positive regulation of myoblast differentiation GO:0045663 8 0.220
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.218
Mouse
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.218
Mouse
anatomical structure homeostasis GO:0060249 145 0.217
divalent inorganic cation transport GO:0072511 178 0.217
positive regulation of b cell proliferation GO:0030890 24 0.216
camera type eye development GO:0043010 266 0.215
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.215
Mouse
response to extracellular stimulus GO:0009991 127 0.214
glial cell apoptotic process GO:0034349 3 0.213
forebrain development GO:0030900 302 0.213
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.211
Mouse
acute phase response GO:0006953 10 0.211
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.210
alpha beta t cell differentiation GO:0046632 69 0.209
defense response to gram positive bacterium GO:0050830 50 0.209
Mouse
molting cycle GO:0042303 90 0.208
Mouse
regulation of establishment of protein localization GO:0070201 181 0.208
Mouse
mesenchymal cell differentiation GO:0048762 107 0.206
regulation of immunoglobulin secretion GO:0051023 12 0.206
Mouse
lung development GO:0030324 164 0.206
hexose metabolic process GO:0019318 98 0.204
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.203
regulation of osteoclast differentiation GO:0045670 36 0.202
regulation of odontogenesis of dentin containing tooth GO:0042487 11 0.201
leukocyte chemotaxis GO:0030595 69 0.201
Human Mouse
protein processing GO:0016485 163 0.201
Mouse
alpha beta t cell proliferation GO:0046633 21 0.200
reactive oxygen species biosynthetic process GO:1903409 8 0.200
positive regulation of hydrolase activity GO:0051345 148 0.200
Mouse
cell type specific apoptotic process GO:0097285 268 0.199
regulation of response to wounding GO:1903034 189 0.198
amide transport GO:0042886 138 0.197
positive regulation of chemotaxis GO:0050921 38 0.196
Mouse
positive regulation of protein kinase b signaling GO:0051897 32 0.195
negative regulation of interleukin 13 production GO:0032696 2 0.195
positive regulation of cytoplasmic transport GO:1903651 40 0.194
Mouse
placenta development GO:0001890 140 0.193
regulation of cell migration GO:0030334 219 0.193
Mouse
liver development GO:0001889 66 0.191
regulation of inflammatory response GO:0050727 147 0.191
t cell receptor signaling pathway GO:0050852 46 0.191
regulation of lymphocyte migration GO:2000401 14 0.190
Mouse
regulation of lipid transport GO:0032368 36 0.188
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.188
positive regulation of glial cell proliferation GO:0060252 4 0.187
lymphocyte activation involved in immune response GO:0002285 93 0.186
Mouse
immune response activating signal transduction GO:0002757 116 0.184
divalent inorganic cation homeostasis GO:0072507 138 0.183
regulation of immunoglobulin mediated immune response GO:0002889 37 0.182
Mouse
respiratory tube development GO:0030323 167 0.182
osteoclast proliferation GO:0002158 4 0.181
response to amino acid GO:0043200 37 0.180
Mouse
positive regulation of programmed cell death GO:0043068 218 0.179
Mouse
antimicrobial peptide production GO:0002775 2 0.179
jnk cascade GO:0007254 72 0.176
prostaglandin secretion GO:0032310 5 0.176
antibacterial peptide biosynthetic process GO:0002780 2 0.175
regulation of protein serine threonine kinase activity GO:0071900 157 0.174
cellular response to abiotic stimulus GO:0071214 56 0.174
immunoglobulin production GO:0002377 73 0.173
Mouse
positive regulation of b cell activation GO:0050871 49 0.173
regulation of protein secretion GO:0050708 82 0.172
Mouse
leukocyte proliferation GO:0070661 172 0.172
negative regulation of ossification GO:0030279 49 0.171
Mouse
mammary gland epithelial cell proliferation GO:0033598 24 0.171
regulation of innate immune response GO:0045088 91 0.171
activation of innate immune response GO:0002218 56 0.170
regulation of cell motility GO:2000145 236 0.169
Mouse
negative regulation of growth of symbiont in host GO:0044130 19 0.168
Mouse
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.168
Mouse
positive regulation of map kinase activity GO:0043406 84 0.167
response to lipopolysaccharide GO:0032496 128 0.167
Mouse
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.167
telencephalon cell migration GO:0022029 55 0.166
regulation of dna recombination GO:0000018 34 0.165
purine ribonucleoside metabolic process GO:0046128 241 0.164
response to acid chemical GO:0001101 111 0.164
Mouse
erk1 and erk2 cascade GO:0070371 77 0.162
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.162
cytokine secretion GO:0050663 72 0.162
protein secretion GO:0009306 111 0.162
Mouse
protein localization to nucleus GO:0034504 121 0.161
Mouse
positive regulation of cell migration GO:0030335 109 0.161
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.159
regulation of monocyte chemotaxis GO:0090025 3 0.159
stress activated mapk cascade GO:0051403 80 0.159
cytosolic calcium ion homeostasis GO:0051480 70 0.158
multicellular organismal signaling GO:0035637 91 0.157
response to nutrient levels GO:0031667 109 0.156
fat cell differentiation GO:0045444 160 0.156
negative regulation of nervous system development GO:0051961 156 0.155
ras protein signal transduction GO:0007265 77 0.155
positive regulation of myeloid cell differentiation GO:0045639 43 0.154
cation transport GO:0006812 399 0.153
regulation of lymphocyte differentiation GO:0045619 107 0.153
spleen development GO:0048536 39 0.153
regulation of membrane potential GO:0042391 192 0.153
digestive tract development GO:0048565 190 0.152
bone remodeling GO:0046849 53 0.152
protein targeting GO:0006605 143 0.151
Mouse
response to decreased oxygen levels GO:0036293 59 0.150
regulation of hormone levels GO:0010817 211 0.149
regulation of intracellular transport GO:0032386 159 0.149
Mouse
regulation of translational initiation GO:0006446 15 0.149
Mouse
cell activation involved in immune response GO:0002263 126 0.148
Mouse
regulation of vasculature development GO:1901342 88 0.148
positive regulation of t cell proliferation GO:0042102 52 0.148
positive regulation of immune effector process GO:0002699 107 0.148
Mouse
neural tube development GO:0021915 160 0.147
cellular protein catabolic process GO:0044257 155 0.147
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.147
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.146
negative regulation of osteoblast differentiation GO:0045668 30 0.146
Mouse
interleukin 12 production GO:0032615 32 0.146
necroptotic process GO:0070266 21 0.146
Mouse
regulation of growth of symbiont in host GO:0044126 19 0.144
Mouse
hepaticobiliary system development GO:0061008 67 0.144
regulation of glial cell differentiation GO:0045685 41 0.144
myeloid leukocyte activation GO:0002274 83 0.143
regulation of ion transport GO:0043269 215 0.143
regulation of translational initiation by iron GO:0006447 2 0.142
Mouse
response to tumor necrosis factor GO:0034612 26 0.140
translation GO:0006412 93 0.139
Mouse
regulation of peptide transport GO:0090087 91 0.138
renal system development GO:0072001 225 0.137
respiratory system development GO:0060541 190 0.136
cellular metal ion homeostasis GO:0006875 151 0.136
positive regulation of acute inflammatory response GO:0002675 16 0.136
oligodendrocyte differentiation GO:0048709 53 0.135
neuronal action potential GO:0019228 54 0.135
macromolecule catabolic process GO:0009057 281 0.134
negative regulation of defense response GO:0031348 77 0.134
positive regulation of cytokine secretion GO:0050715 41 0.132
regulation of branching involved in salivary gland morphogenesis GO:0060693 11 0.132
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.131
bone resorption GO:0045453 38 0.130
protein import GO:0017038 101 0.129
Mouse
digestive tract morphogenesis GO:0048546 147 0.129
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.128
Mouse
antigen processing and presentation GO:0019882 47 0.126
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.126
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.126
Mouse
cytoplasmic transport GO:0016482 234 0.125
Mouse
positive regulation of t cell activation GO:0050870 101 0.124
Human Mouse
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.124
positive regulation of response to wounding GO:1903036 66 0.122
defense response to virus GO:0051607 68 0.122
peptide hormone secretion GO:0030072 109 0.122
regulation of neuron differentiation GO:0045664 281 0.121
circadian temperature homeostasis GO:0060086 2 0.121
regulation of mapk cascade GO:0043408 248 0.121
positive regulation of osteoclast development GO:2001206 3 0.121
regulation of cytoplasmic transport GO:1903649 112 0.121
Mouse
regulation of homeostatic process GO:0032844 182 0.120
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.119
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.118
glucose transport GO:0015758 56 0.118
Mouse
connective tissue development GO:0061448 179 0.117
negative regulation of leukocyte proliferation GO:0070664 46 0.117
negative regulation of b cell proliferation GO:0030889 13 0.116
pattern recognition receptor signaling pathway GO:0002221 47 0.116
epithelial to mesenchymal transition GO:0001837 47 0.115
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.115
positive regulation of oligodendrocyte differentiation GO:0048714 9 0.114
regulation of kinase activity GO:0043549 249 0.114
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.113
response to peptide GO:1901652 136 0.112
developmental growth involved in morphogenesis GO:0060560 138 0.112
positive regulation of cytokine production involved in immune response GO:0002720 19 0.112
developmental programmed cell death GO:0010623 41 0.111
Mouse
central nervous system neuron differentiation GO:0021953 162 0.110
organic hydroxy compound metabolic process GO:1901615 203 0.110
Fly
regulation of leukocyte differentiation GO:1902105 159 0.110
hormone secretion GO:0046879 128 0.109
cellular response to peptide GO:1901653 92 0.108
peptidyl tyrosine modification GO:0018212 145 0.108
peptidyl tyrosine phosphorylation GO:0018108 143 0.106
kidney development GO:0001822 213 0.106
regulation of translation GO:0006417 71 0.105
Mouse
regulation of lymphocyte activation GO:0051249 240 0.104
Human Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.104
cellular response to peptide hormone stimulus GO:0071375 92 0.102
cytokine biosynthetic process GO:0042089 68 0.102
b cell apoptotic process GO:0001783 19 0.101
regulation of cytoskeleton organization GO:0051493 122 0.101
positive regulation of t cell costimulation GO:2000525 2 0.100
steroid metabolic process GO:0008202 119 0.100
purine ribonucleoside catabolic process GO:0046130 205 0.100
mesenchymal cell development GO:0014031 93 0.100
regulation of interleukin 12 production GO:0032655 30 0.099
appendage morphogenesis GO:0035107 149 0.099
digestive system development GO:0055123 200 0.099
positive regulation of cytokine biosynthetic process GO:0042108 40 0.099
eosinophil degranulation GO:0043308 1 0.098
regulation of map kinase activity GO:0043405 120 0.098
mammary gland morphogenesis GO:0060443 54 0.096
positive regulation of protein modification process GO:0031401 299 0.095
negative regulation of apoptotic signaling pathway GO:2001234 104 0.095
skin development GO:0043588 220 0.095
Mouse
myotube differentiation GO:0014902 105 0.095
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.095
membrane organization GO:0061024 245 0.094
Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.094
cellular response to external stimulus GO:0071496 88 0.094
maternal placenta development GO:0001893 20 0.093
regulation of cellular response to stress GO:0080135 159 0.093
stem cell differentiation GO:0048863 268 0.092
single organism cell adhesion GO:0098602 156 0.092
Human
prostaglandin transport GO:0015732 7 0.091
negative regulation of t cell activation GO:0050868 65 0.091
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.090
appendage development GO:0048736 166 0.090
activation of jun kinase activity GO:0007257 15 0.090
t cell extravasation GO:0072683 4 0.090
regulation of fever generation GO:0031620 6 0.089
cerebral cortex development GO:0021987 86 0.089
small molecule biosynthetic process GO:0044283 132 0.089
embryonic organ morphogenesis GO:0048562 276 0.088
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.087
Human
positive regulation of monocyte chemotaxis GO:0090026 2 0.087
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.087
regulation of cell cycle GO:0051726 281 0.087
cellular response to lipid GO:0071396 145 0.086
Mouse
regulation of protein localization to nucleus GO:1900180 60 0.086
Mouse
necroptotic signaling pathway GO:0097527 3 0.086
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.086
guanosine containing compound metabolic process GO:1901068 144 0.086
regulation of interleukin 10 production GO:0032653 21 0.086
negative regulation of cytokine production GO:0001818 84 0.086
canonical wnt signaling pathway GO:0060070 130 0.085
negative regulation of alpha beta t cell activation GO:0046636 18 0.085
single organism nuclear import GO:1902593 95 0.085
Mouse
negative regulation of cell development GO:0010721 169 0.085
regulation of cytokine production involved in immune response GO:0002718 26 0.084
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.084
antimicrobial peptide biosynthetic process GO:0002777 2 0.084
mitotic cell cycle GO:0000278 195 0.083
regulation of myeloid leukocyte differentiation GO:0002761 58 0.083
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.082
Mouse
alpha beta t cell activation involved in immune response GO:0002287 31 0.082
regulation of alpha beta t cell proliferation GO:0046640 18 0.082
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.082
forebrain generation of neurons GO:0021872 63 0.082
epidermis morphogenesis GO:0048730 33 0.081

Tnfsf11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.849
Human
musculoskeletal system disease DOID:17 0 0.849
Human
connective tissue disease DOID:65 0 0.733
Human
bone remodeling disease DOID:0080005 0 0.661
Human
bone disease DOID:0080001 0 0.661
Human