Mus musculus

158 known processes

Top2a

topoisomerase (DNA) II alpha

(Aliases: Top-2)

Top2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spindle assembly involved in mitosis GO:0090307 4 0.813
organelle assembly GO:0070925 177 0.695
meiosis i GO:0007127 60 0.680
Yeast
mitotic cell cycle GO:0000278 195 0.602
Yeast
microtubule cytoskeleton organization GO:0000226 157 0.570
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.548
mitotic cytokinesis GO:0000281 4 0.529
mitotic cell cycle process GO:1903047 159 0.528
Yeast
protein depolymerization GO:0051261 34 0.460
female meiosis chromosome segregation GO:0016321 1 0.455
dna metabolic process GO:0006259 303 0.448
meiotic cell cycle process GO:1903046 77 0.447
Yeast
establishment of organelle localization GO:0051656 122 0.438
chromatin organization GO:0006325 206 0.424
Yeast
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.418
meiotic nuclear division GO:0007126 115 0.402
Yeast
microtubule based process GO:0007017 236 0.375
regulation of spindle organization GO:0090224 2 0.335
cytokinetic process GO:0032506 2 0.334
protein complex disassembly GO:0043241 40 0.324
regulation of microtubule depolymerization GO:0031114 13 0.322
microtubule depolymerization GO:0007019 15 0.317
negative regulation of protein depolymerization GO:1901880 21 0.302
modification dependent protein catabolic process GO:0019941 133 0.298
negative regulation of microtubule depolymerization GO:0007026 13 0.291
mitotic nuclear division GO:0007067 48 0.288
negative regulation of mitotic cell cycle GO:0045930 58 0.277
Yeast
centrosome cycle GO:0007098 23 0.272
mitotic chromosome condensation GO:0007076 1 0.271
synapsis GO:0007129 34 0.270
spindle assembly involved in meiosis GO:0090306 4 0.268
microtubule polymerization or depolymerization GO:0031109 26 0.264
regulation of mitotic spindle organization GO:0060236 2 0.252
meiotic cell cycle GO:0051321 122 0.242
Yeast
male meiosis GO:0007140 37 0.231
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.225
microtubule based movement GO:0007018 84 0.222
regulation of protein complex disassembly GO:0043244 28 0.205
gonad development GO:0008406 141 0.204
cellular nitrogen compound catabolic process GO:0044270 280 0.199
negative regulation of cellular component organization GO:0051129 194 0.198
organelle fission GO:0048285 170 0.198
Yeast
chromosome segregation GO:0007059 48 0.197
negative regulation of cell cycle phase transition GO:1901988 48 0.194
Yeast
spindle assembly involved in female meiosis GO:0007056 3 0.175
regulation of mitotic cell cycle GO:0007346 126 0.175
Yeast
cellular protein catabolic process GO:0044257 155 0.175
mitotic sister chromatid segregation GO:0000070 14 0.160
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.160
negative regulation of cell cycle GO:0045786 123 0.159
Yeast
mitotic cell cycle checkpoint GO:0007093 31 0.158
Yeast
regulation of protein depolymerization GO:1901879 26 0.157
regulation of protein localization GO:0032880 231 0.150
attachment of spindle microtubules to kinetochore GO:0008608 4 0.149
development of primary sexual characteristics GO:0045137 143 0.146
female meiotic division GO:0007143 21 0.137
positive regulation of nfat protein import into nucleus GO:0051533 1 0.135
regulation of chromosome organization GO:0033044 83 0.134
macromolecular complex disassembly GO:0032984 43 0.130
cleavage furrow formation GO:0036089 2 0.128
spindle midzone assembly GO:0051255 1 0.123
organelle localization GO:0051640 179 0.122
mitotic centrosome separation GO:0007100 4 0.121
dna repair GO:0006281 107 0.118
dna conformation change GO:0071103 37 0.117
female meiosis i GO:0007144 7 0.116
aromatic compound catabolic process GO:0019439 286 0.116
nuclear dna replication GO:0033260 3 0.113
synaptonemal complex assembly GO:0007130 13 0.113
posttranscriptional regulation of gene expression GO:0010608 155 0.111
Worm
centrosome separation GO:0051299 4 0.111
nuclear division GO:0000280 158 0.109
Yeast
regulation of exit from mitosis GO:0007096 1 0.109
regulation of cell division GO:0051302 76 0.107
cell cycle checkpoint GO:0000075 47 0.107
Yeast
regulation of dna replication GO:0006275 17 0.102
Yeast
astral microtubule organization GO:0030953 3 0.102
macromolecule catabolic process GO:0009057 281 0.102
spindle organization GO:0007051 28 0.101
oocyte maturation GO:0001556 18 0.100
negative regulation of protein metabolic process GO:0051248 282 0.099
cellular protein complex disassembly GO:0043624 36 0.099
mitotic spindle organization GO:0007052 10 0.098
protein catabolic process GO:0030163 221 0.098
ubiquitin dependent protein catabolic process GO:0006511 129 0.096
genitalia development GO:0048806 37 0.096
centrosome duplication GO:0051298 16 0.095
meiotic cytokinesis GO:0033206 5 0.090
endocytosis GO:0006897 168 0.089
peptidyl amino acid modification GO:0018193 336 0.089
spermatogenesis GO:0007283 284 0.085
positive regulation of intracellular transport GO:0032388 70 0.084
maintenance of location GO:0051235 89 0.084
regulation of organelle organization GO:0033043 289 0.082
regulation of microtubule based process GO:0032886 52 0.081
metaphase plate congression GO:0051310 2 0.076
negative regulation of proteolysis GO:0045861 74 0.076
gene silencing GO:0016458 38 0.076
Worm
regulation of protein maturation GO:1903317 96 0.075
male gamete generation GO:0048232 285 0.074
single organism nuclear import GO:1902593 95 0.074
ribonucleoside metabolic process GO:0009119 245 0.073
positive regulation of cell cycle GO:0045787 92 0.073
negative regulation of cellular protein metabolic process GO:0032269 247 0.073
regulation of cytoskeleton organization GO:0051493 122 0.072
translesion synthesis GO:0019985 1 0.070
organic cyclic compound catabolic process GO:1901361 295 0.070
regulation of mitotic sister chromatid segregation GO:0033047 12 0.070
fertilization GO:0009566 127 0.068
protein localization to organelle GO:0033365 185 0.065
cell division GO:0051301 120 0.064
spindle assembly GO:0051225 13 0.064
cellular protein complex assembly GO:0043623 116 0.063
heterocycle catabolic process GO:0046700 280 0.062
regulation of cell cycle phase transition GO:1901987 77 0.061
Yeast
spindle checkpoint GO:0031577 12 0.061
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.061
negative regulation of organelle organization GO:0010639 90 0.060
regulation of intracellular protein transport GO:0033157 82 0.059
regulation of nuclear cell cycle dna replication GO:0033262 2 0.059
negative regulation of meiotic cell cycle GO:0051447 14 0.058
regulation of cytoplasmic transport GO:1903649 112 0.058
cellular macromolecule catabolic process GO:0044265 206 0.057
single fertilization GO:0007338 82 0.057
covalent chromatin modification GO:0016569 163 0.056
positive regulation of protein transport GO:0051222 93 0.056
purine nucleotide catabolic process GO:0006195 211 0.056
purine ribonucleotide metabolic process GO:0009150 290 0.055
regulation of protein localization to nucleus GO:1900180 60 0.055
negative regulation of cytoskeleton organization GO:0051494 36 0.055
positive regulation of cellular amine metabolic process GO:0033240 5 0.055
meiotic chromosome segregation GO:0045132 19 0.055
dna recombination GO:0006310 92 0.055
Yeast
histone serine phosphorylation GO:0035404 5 0.055
regulation of cell cycle GO:0051726 281 0.053
Yeast
ribonucleoside catabolic process GO:0042454 206 0.053
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.053
regulation of transferase activity GO:0051338 263 0.053
double strand break repair GO:0006302 48 0.052
dna packaging GO:0006323 30 0.052
spindle assembly involved in female meiosis i GO:0007057 2 0.052
cellular amino acid metabolic process GO:0006520 103 0.051
peptidyl serine phosphorylation GO:0018105 74 0.051
regulation of protein transport GO:0051223 163 0.050
protein modification by small protein conjugation GO:0032446 187 0.050
germ cell development GO:0007281 185 0.050
microtubule organizing center organization GO:0031023 28 0.050
negative regulation of protein complex disassembly GO:0043242 22 0.049
regulation of cellular amine metabolic process GO:0033238 20 0.049
regulation of cellular catabolic process GO:0031329 242 0.049
regulation of protein targeting GO:1903533 61 0.049
histone modification GO:0016570 159 0.049
regulation of meiosis i GO:0060631 7 0.048
regulation of cellular amino acid metabolic process GO:0006521 5 0.048
ribonucleoside triphosphate catabolic process GO:0009203 199 0.047
regulation of cell cycle process GO:0010564 160 0.047
Yeast
establishment of protein localization to organelle GO:0072594 118 0.046
regulation of nucleocytoplasmic transport GO:0046822 73 0.046
positive regulation of cytoplasmic transport GO:1903651 40 0.046
cellular ketone metabolic process GO:0042180 84 0.045
regulation of mitotic cell cycle phase transition GO:1901990 73 0.045
Yeast
regulation of establishment of protein localization GO:0070201 181 0.045
positive regulation of protein modification process GO:0031401 299 0.044
intracellular protein transport GO:0006886 204 0.044
regulation of cellular ketone metabolic process GO:0010565 66 0.043
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.043
cytokinesis GO:0000910 17 0.043
amine metabolic process GO:0009308 45 0.043
cellular response to dna damage stimulus GO:0006974 207 0.043
Human
protein localization to nucleus GO:0034504 121 0.042
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.042
protein modification by small protein conjugation or removal GO:0070647 207 0.042
chromatin modification GO:0016568 187 0.042
Yeast
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.041
Yeast
negative regulation of cell cycle process GO:0010948 69 0.041
Yeast
developmental maturation GO:0021700 193 0.041
cellular amine metabolic process GO:0044106 44 0.041
protein processing GO:0016485 163 0.040
dendrite development GO:0016358 115 0.040
spindle localization GO:0051653 22 0.040
rho protein signal transduction GO:0007266 32 0.040
histone phosphorylation GO:0016572 9 0.039
wnt signaling pathway GO:0016055 188 0.038
purine nucleoside metabolic process GO:0042278 241 0.038
regulation of protein import into nucleus GO:0042306 52 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.037
protein maturation GO:0051604 176 0.037
regulation of intracellular transport GO:0032386 159 0.036
protein import GO:0017038 101 0.036
proteasomal protein catabolic process GO:0010498 98 0.036
positive regulation of nervous system development GO:0051962 221 0.036
ribonucleoside triphosphate metabolic process GO:0009199 220 0.035
negative regulation of phosphorus metabolic process GO:0010563 184 0.035
protein targeting GO:0006605 143 0.035
cell type specific apoptotic process GO:0097285 268 0.035
regulation of proteasomal protein catabolic process GO:0061136 46 0.035
dna endoreduplication GO:0042023 4 0.035
chromosome organization involved in meiosis GO:0070192 39 0.035
protein import into nucleus GO:0006606 95 0.035
muscle cell differentiation GO:0042692 261 0.035
regulation of cellular response to stress GO:0080135 159 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
neural tube development GO:0021915 160 0.034
nuclear transport GO:0051169 139 0.034
microtubule nucleation GO:0007020 2 0.034
regulation of kinase activity GO:0043549 249 0.034
regulation of chromatin silencing GO:0031935 2 0.034
purine ribonucleoside metabolic process GO:0046128 241 0.033
purine nucleoside catabolic process GO:0006152 205 0.033
regulation of microtubule cytoskeleton organization GO:0070507 37 0.033
ribonucleotide catabolic process GO:0009261 208 0.033
maintenance of location in cell GO:0051651 24 0.032
glycosyl compound catabolic process GO:1901658 206 0.032
peptidyl threonine phosphorylation GO:0018107 31 0.032
purine nucleotide metabolic process GO:0006163 302 0.032
peptidyl serine modification GO:0018209 83 0.032
positive regulation of dna replication GO:0045740 9 0.031
positive regulation of intracellular protein transport GO:0090316 42 0.031
dna catabolic process exonucleolytic GO:0000738 3 0.031
nucleoside phosphate catabolic process GO:1901292 222 0.031
cell aging GO:0007569 35 0.031
purine nucleoside triphosphate metabolic process GO:0009144 226 0.030
mitotic spindle assembly checkpoint GO:0007094 7 0.030
negative regulation of cellular protein catabolic process GO:1903363 22 0.030
neuron migration GO:0001764 122 0.030
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.030
protein ubiquitination GO:0016567 171 0.029
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.029
negative regulation of sister chromatid segregation GO:0033046 7 0.028
cation transport GO:0006812 399 0.028
nucleoside phosphate metabolic process GO:0006753 338 0.028
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.028
sister chromatid segregation GO:0000819 20 0.027
multi multicellular organism process GO:0044706 109 0.027
muscle tissue development GO:0060537 308 0.026
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.026
kinetochore organization GO:0051383 2 0.026
negative regulation of protein maturation GO:1903318 79 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
modification dependent macromolecule catabolic process GO:0043632 133 0.025
peptidyl threonine modification GO:0018210 31 0.025
regulation of cell motility GO:2000145 236 0.025
regulation of protein processing GO:0070613 96 0.025
rna processing GO:0006396 105 0.025
ribonucleotide metabolic process GO:0009259 291 0.025
negative regulation of mitosis GO:0045839 10 0.024
dna replication GO:0006260 52 0.024
Yeast
positive regulation of protein phosphorylation GO:0001934 242 0.024
regulation of cellular protein catabolic process GO:1903362 61 0.024
neural tube closure GO:0001843 90 0.024
recombinational repair GO:0000725 21 0.024
negative regulation of chromosome organization GO:2001251 30 0.024
regulation of chromosome segregation GO:0051983 21 0.023
positive regulation of hydrolase activity GO:0051345 148 0.023
positive regulation of protein import into nucleus GO:0042307 26 0.023
nuclear import GO:0051170 95 0.023
nucleoside catabolic process GO:0009164 206 0.023
regulation of proteolysis GO:0030162 164 0.023
cytoplasmic transport GO:0016482 234 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
positive regulation of protein localization to nucleus GO:1900182 30 0.023
nuclear migration GO:0007097 6 0.023
regulation of protein serine threonine kinase activity GO:0071900 157 0.022
positive regulation of nucleotide metabolic process GO:0045981 114 0.022
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.022
positive regulation of meiotic cell cycle GO:0051446 15 0.022
dna integrity checkpoint GO:0031570 28 0.022
Yeast
neural tube formation GO:0001841 108 0.022
meiotic spindle organization GO:0000212 9 0.022
asymmetric neuroblast division GO:0055059 1 0.022
endomembrane system organization GO:0010256 147 0.022
establishment or maintenance of cell polarity GO:0007163 86 0.022
purine nucleoside triphosphate catabolic process GO:0009146 203 0.022
wound healing GO:0042060 157 0.022
positive regulation of organelle organization GO:0010638 128 0.022
purine containing compound catabolic process GO:0072523 213 0.022
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.022
nucleoside metabolic process GO:0009116 246 0.022
negative regulation of phosphate metabolic process GO:0045936 184 0.022
positive regulation of cellular catabolic process GO:0031331 148 0.021
mrna processing GO:0006397 63 0.021
ras protein signal transduction GO:0007265 77 0.021
centrosome organization GO:0051297 26 0.021
cellularization GO:0007349 1 0.021
negative regulation of apoptotic signaling pathway GO:2001234 104 0.021
chromosome movement towards spindle pole GO:0051305 3 0.021
negative regulation of cellular catabolic process GO:0031330 47 0.021
nucleotide catabolic process GO:0009166 217 0.021
female gamete generation GO:0007292 74 0.020
regulation of cytokinesis GO:0032465 5 0.020
positive regulation of protein kinase activity GO:0045860 144 0.020
microtubule anchoring GO:0034453 9 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
response to organonitrogen compound GO:0010243 246 0.020
regulation of apoptotic signaling pathway GO:2001233 197 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
asymmetric stem cell division GO:0098722 3 0.020
dephosphorylation GO:0016311 129 0.020
digestive system development GO:0055123 200 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
cellular chemical homeostasis GO:0055082 215 0.019
regulation of cell projection organization GO:0031344 206 0.019
cell maturation GO:0048469 127 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
cellular response to lipid GO:0071396 145 0.019
striated muscle tissue development GO:0014706 293 0.019
nucleotide metabolic process GO:0009117 332 0.018
apoptotic signaling pathway GO:0097190 306 0.018
establishment of spindle orientation GO:0051294 15 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.018
establishment of meiotic spindle orientation GO:0051296 1 0.018
regulation of meiotic cell cycle GO:0051445 34 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.018
regulation of protein kinase activity GO:0045859 232 0.018
positive regulation of cell development GO:0010720 237 0.018
cdc42 protein signal transduction GO:0032488 0 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.017
regulation of hydrolase activity GO:0051336 246 0.017
centromere complex assembly GO:0034508 3 0.017
protein dna complex subunit organization GO:0071824 28 0.017
regulation of neuron projection development GO:0010975 169 0.017
regulation of chromatin binding GO:0035561 7 0.017
cellular homeostasis GO:0019725 240 0.017
receptor mediated endocytosis GO:0006898 51 0.017
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.017
microtubule sliding GO:0051012 1 0.017
chromosome separation GO:0051304 14 0.017
regulation of neuron differentiation GO:0045664 281 0.017
leukocyte homeostasis GO:0001776 79 0.017
positive regulation of transferase activity GO:0051347 167 0.017
forebrain development GO:0030900 302 0.017
Mouse
response to oxygen levels GO:0070482 62 0.017
protein localization to chromosome centromeric region GO:0071459 1 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.017
response to organic cyclic compound GO:0014070 198 0.017
positive regulation of nucleoside metabolic process GO:0045979 91 0.016
regulation of secretion GO:0051046 274 0.016
stem cell differentiation GO:0048863 268 0.016
regulation of protein catabolic process GO:0042176 108 0.016
embryonic placenta development GO:0001892 98 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.016
neural precursor cell proliferation GO:0061351 121 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
blastocyst development GO:0001824 80 0.016
regulation of cell activation GO:0050865 289 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.015
positive regulation of kinase activity GO:0033674 155 0.015
organ growth GO:0035265 117 0.015
regulation of dna dependent dna replication GO:0090329 8 0.015
Yeast
mrna metabolic process GO:0016071 84 0.015
response to oxidative stress GO:0006979 123 0.015
positive regulation of mitotic cell cycle GO:0045931 41 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
positive regulation of chromatin modification GO:1903310 28 0.015
cardiac muscle cell differentiation GO:0055007 69 0.015
mapk cascade GO:0000165 281 0.015
membrane organization GO:0061024 245 0.015
positive regulation of gtp catabolic process GO:0033126 85 0.015
meiosis ii GO:0007135 7 0.015
regulation of protein stability GO:0031647 52 0.015
transcription factor import into nucleus GO:0042991 26 0.015
regulation of secretion by cell GO:1903530 249 0.015
regulation of mapk cascade GO:0043408 248 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
positive regulation of chromosome segregation GO:0051984 4 0.015
striated muscle cell development GO:0055002 125 0.014
stem cell development GO:0048864 219 0.014
negative regulation of transferase activity GO:0051348 85 0.014
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
blood vessel morphogenesis GO:0048514 285 0.014
mitotic sister chromatid separation GO:0051306 9 0.014
positive regulation of cell cycle process GO:0090068 61 0.014
cyclin catabolic process GO:0008054 1 0.014
nfat protein import into nucleus GO:0051531 6 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
cardiocyte differentiation GO:0035051 87 0.014
oocyte development GO:0048599 33 0.014
cerebral cortex development GO:0021987 86 0.014
cell cycle g2 m phase transition GO:0044839 20 0.014
digestive tract development GO:0048565 190 0.014
chromatin silencing GO:0006342 15 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
nucleus localization GO:0051647 20 0.013
negative regulation of molecular function GO:0044092 258 0.013
regulation of mitosis GO:0007088 29 0.013
acylglycerol metabolic process GO:0006639 55 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
regulation of multi organism process GO:0043900 111 0.013
Human
carbohydrate derivative catabolic process GO:1901136 231 0.013
g2 m transition of mitotic cell cycle GO:0000086 20 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
telencephalon development GO:0021537 186 0.013
neuron apoptotic process GO:0051402 142 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
muscle cell development GO:0055001 133 0.013
smoothened signaling pathway GO:0007224 105 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
multicellular organism growth GO:0035264 161 0.013
cell fate commitment GO:0045165 210 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
regulation of cell migration GO:0030334 219 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
canonical wnt signaling pathway GO:0060070 130 0.013
carbohydrate homeostasis GO:0033500 128 0.012
dna catabolic process GO:0006308 19 0.012
heart growth GO:0060419 45 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
negative regulation of gene expression epigenetic GO:0045814 15 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
angiogenesis GO:0001525 201 0.012
regulation of dephosphorylation GO:0035303 18 0.012
epithelial cell proliferation GO:0050673 174 0.012
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.012
double strand break repair via homologous recombination GO:0000724 21 0.012
placenta development GO:0001890 140 0.012
atp metabolic process GO:0046034 75 0.012
regulation of transcription factor import into nucleus GO:0042990 24 0.012
glycerolipid metabolic process GO:0046486 122 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
response to inorganic substance GO:0010035 96 0.012
positive regulation of nucleotide catabolic process GO:0030813 88 0.012
mrna 3 end processing GO:0031124 16 0.012
regulation of neuron death GO:1901214 134 0.012
cellular glucose homeostasis GO:0001678 52 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
atp catabolic process GO:0006200 55 0.012
protein secretion GO:0009306 111 0.012
guanosine containing compound metabolic process GO:1901068 144 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of chromatin organization GO:1902275 57 0.012
male meiosis chromosome segregation GO:0007060 3 0.012
actin cytoskeleton organization GO:0030036 220 0.012
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051439 1 0.012
regulation of homeostatic process GO:0032844 182 0.012
positive regulation of nuclear cell cycle dna replication GO:0010571 1 0.011
cellular lipid metabolic process GO:0044255 323 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
mitotic cell cycle embryonic GO:0045448 5 0.011
spermatid differentiation GO:0048515 115 0.011
chemotaxis GO:0006935 247 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
tube closure GO:0060606 91 0.011
negative regulation of kinase activity GO:0033673 81 0.011
cell adhesion GO:0007155 329 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
regulation of hormone levels GO:0010817 211 0.011
positive regulation of nuclear division GO:0051785 27 0.011
regulation of nuclear division GO:0051783 56 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
mitotic g2 dna damage checkpoint GO:0007095 8 0.011
cardiac cell development GO:0055006 41 0.011
glucose homeostasis GO:0042593 128 0.011
dna damage checkpoint GO:0000077 26 0.011
regulation of double strand break repair via nonhomologous end joining GO:2001032 2 0.011
gland development GO:0048732 330 0.011
pallium development GO:0021543 120 0.010
homeostasis of number of cells GO:0048872 210 0.010
ameboidal type cell migration GO:0001667 128 0.010
organelle disassembly GO:1903008 2 0.010
rna interference GO:0016246 2 0.010
Worm
positive regulation of cell division GO:0051781 31 0.010
dna methylation GO:0006306 43 0.010
leukocyte differentiation GO:0002521 342 0.010
urogenital system development GO:0001655 261 0.010
tube formation GO:0035148 140 0.010
dna dependent dna replication GO:0006261 24 0.010
Yeast
regulation of asymmetric cell division GO:0009786 4 0.010
regulation of muscle tissue development GO:1901861 97 0.010

Top2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
physical disorder DOID:0080015 0 0.011
disease of cellular proliferation DOID:14566 0 0.010
cancer DOID:162 0 0.010