Mus musculus

518 known processes

Trp53

transformation related protein 53

(Aliases: bbl,Tp53,bhy,bfy,p44,p53)

Trp53 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 1.000
signal transduction involved in dna damage checkpoint GO:0072422 3 1.000
signal transduction involved in dna integrity checkpoint GO:0072401 3 1.000
cellular response to gamma radiation GO:0071480 4 1.000
Fly
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 1.000
mitotic g1 dna damage checkpoint GO:0031571 4 1.000
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 1.000
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 1.000
release of cytochrome c from mitochondria GO:0001836 23 1.000
cell cycle checkpoint GO:0000075 47 1.000
positive regulation of apoptotic process GO:0043065 217 1.000
dna metabolic process GO:0006259 303 1.000
cell aging GO:0007569 35 1.000
cellular response to radiation GO:0071478 28 1.000
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 1.000
response to ionizing radiation GO:0010212 42 1.000
negative regulation of mitotic cell cycle GO:0045930 58 1.000
dna integrity checkpoint GO:0031570 28 1.000
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 1.000
signal transduction by p53 class mediator GO:0072331 51 1.000
signal transduction involved in cell cycle checkpoint GO:0072395 3 1.000
g1 s transition of mitotic cell cycle GO:0000082 57 1.000
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 1.000
regulation of protein stability GO:0031647 52 1.000
regulation of cell cycle process GO:0010564 160 1.000
cell cycle arrest GO:0007050 37 1.000
regulation of mitotic cell cycle GO:0007346 126 1.000
negative regulation of fibroblast proliferation GO:0048147 14 1.000
apoptotic process involved in mammary gland involution GO:0060057 4 1.000
negative regulation of protein serine threonine kinase activity GO:0071901 49 1.000
Mouse
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 1.000
regulation of cell cycle GO:0051726 281 1.000
regulation of mitotic cell cycle phase transition GO:1901990 73 1.000
negative regulation of cell cycle GO:0045786 123 1.000
positive regulation of lymphocyte apoptotic process GO:0070230 13 1.000
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 1.000
fibroblast proliferation GO:0048144 35 1.000
covalent chromatin modification GO:0016569 163 1.000
intrinsic apoptotic signaling pathway GO:0097193 132 1.000
b cell lineage commitment GO:0002326 4 1.000
cellular senescence GO:0090398 11 1.000
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 45 1.000
negative regulation of cell cycle phase transition GO:1901988 48 1.000
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 1.000
glial cell apoptotic process GO:0034349 3 1.000
Human
dna damage checkpoint GO:0000077 26 1.000
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 1.000
regulation of fibroblast proliferation GO:0048145 34 1.000
regulation of dna replication GO:0006275 17 1.000
response to x ray GO:0010165 11 1.000
positive regulation of leukocyte apoptotic process GO:2000108 21 1.000
dna replication GO:0006260 52 1.000
regulation of cell cycle g1 s phase transition GO:1902806 35 1.000
negative regulation of protein metabolic process GO:0051248 282 1.000
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 3 1.000
negative regulation of dna replication GO:0008156 4 1.000
modification dependent macromolecule catabolic process GO:0043632 133 1.000
response to oxygen levels GO:0070482 62 1.000
Human Zebrafish Worm
positive regulation of peptidase activity GO:0010952 49 1.000
Zebrafish Fly
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 1.000
Mouse
cell cycle g1 s phase transition GO:0044843 57 1.000
negative regulation of growth GO:0045926 99 1.000
Human
positive regulation of proteolysis GO:0045862 85 1.000
Zebrafish Fly
positive regulation of apoptotic signaling pathway GO:2001235 95 1.000
Human Mouse
negative regulation of cell proliferation GO:0008285 296 1.000
positive regulation of mitotic sister chromatid separation GO:1901970 2 1.000
mitochondrial dna repair GO:0043504 3 1.000
mitotic cell cycle arrest GO:0071850 4 1.000
t cell proliferation GO:0042098 120 1.000
regulation of melanocyte differentiation GO:0045634 7 1.000
chromatin modification GO:0016568 187 1.000
negative regulation of cell cycle arrest GO:0071157 1 1.000
positive regulation of cell cycle GO:0045787 92 1.000
regulation of cellular protein catabolic process GO:1903362 61 1.000
negative regulation of cell size GO:0045792 3 1.000
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 1.000
lymphocyte proliferation GO:0046651 164 1.000
mitotic cell cycle checkpoint GO:0007093 31 1.000
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 1.000
response to ischemia GO:0002931 14 1.000
regulation of cell cycle phase transition GO:1901987 77 1.000
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 1.000
negative regulation of cellular protein metabolic process GO:0032269 247 1.000
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 1.000
Fly
regulation of cell cycle arrest GO:0071156 12 1.000
cellular response to ionizing radiation GO:0071479 11 1.000
negative regulation of protein modification process GO:0031400 163 1.000
Mouse
positive regulation of mammary gland involution GO:1903521 4 1.000
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 1.000
proteolysis involved in cellular protein catabolic process GO:0051603 147 1.000
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 1.000
positive regulation of cell cycle phase transition GO:1901989 17 1.000
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 1.000
response to endoplasmic reticulum stress GO:0034976 53 1.000
Human
dna damage response signal transduction by p53 class mediator GO:0030330 19 1.000
regulation of reactive oxygen species metabolic process GO:2000377 40 1.000
negative regulation of cell cycle process GO:0010948 69 1.000
regulation of proteasomal protein catabolic process GO:0061136 46 1.000
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 1.000
regulation of cellular response to stress GO:0080135 159 1.000
negative regulation of epithelial cell proliferation GO:0050680 64 1.000
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 1.000
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 1.000
mitotic cell cycle GO:0000278 195 1.000
regulation of protein maturation GO:1903317 96 1.000
regulation of protein deacetylation GO:0090311 17 1.000
ubiquitin dependent protein catabolic process GO:0006511 129 1.000
cellular protein catabolic process GO:0044257 155 0.999
cellular macromolecule catabolic process GO:0044265 206 0.999
apoptotic signaling pathway GO:0097190 306 0.999
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.999
skeletal system development GO:0001501 356 0.999
Mouse
regulation of transferase activity GO:0051338 263 0.999
Mouse Fly
negative regulation of protein phosphorylation GO:0001933 126 0.999
Mouse
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.999
positive regulation of chromosome organization GO:2001252 33 0.999
activation of cysteine type endopeptidase activity GO:0097202 27 0.999
Fly
dna biosynthetic process GO:0071897 22 0.999
regionalization GO:0003002 337 0.999
regulation of kinase activity GO:0043549 249 0.999
Mouse Fly
regulation of ubiquitin protein transferase activity GO:0051438 7 0.999
regulation of proteolysis GO:0030162 164 0.999
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.999
negative regulation of proteolysis GO:0045861 74 0.999
negative regulation of phosphorylation GO:0042326 166 0.999
Mouse Fly
leukocyte proliferation GO:0070661 172 0.999
protein catabolic process GO:0030163 221 0.999
striated muscle tissue development GO:0014706 293 0.999
modification dependent protein catabolic process GO:0019941 133 0.999
positive regulation of cell aging GO:0090343 1 0.999
regulation of chromosome organization GO:0033044 83 0.999
telomere capping GO:0016233 4 0.999
regulation of epithelial cell proliferation GO:0050678 141 0.999
Mouse
proteasomal protein catabolic process GO:0010498 98 0.999
regulation of response to dna damage stimulus GO:2001020 34 0.999
Mouse Fly
cellular response to light stimulus GO:0071482 19 0.999
extrinsic apoptotic signaling pathway GO:0097191 126 0.999
protein modification by small protein conjugation or removal GO:0070647 207 0.999
cellular response to oxidative stress GO:0034599 76 0.999
Human
posttranscriptional regulation of gene expression GO:0010608 155 0.999
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.998
immature b cell differentiation GO:0002327 10 0.998
response to radiation GO:0009314 165 0.998
positive regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902231 6 0.998
Mouse
epithelial cell proliferation GO:0050673 174 0.998
Mouse
double strand break repair GO:0006302 48 0.998
pigment cell differentiation GO:0050931 27 0.998
mitotic cell cycle process GO:1903047 159 0.998
regulation of protein kinase activity GO:0045859 232 0.998
Mouse
peptidyl amino acid modification GO:0018193 336 0.998
melanocyte differentiation GO:0030318 25 0.998
t cell activation GO:0042110 289 0.998
positive regulation of glial cell proliferation GO:0060252 4 0.998
mammary gland epithelial cell proliferation GO:0033598 24 0.998
mammary gland epithelium development GO:0061180 65 0.998
response to light stimulus GO:0009416 135 0.998
regulation of b cell apoptotic process GO:0002902 13 0.998
positive regulation of hydrolase activity GO:0051345 148 0.998
Zebrafish Fly
regulation of mammary gland involution GO:1903519 4 0.998
regulation of binding GO:0051098 111 0.998
regulation of cellular ketone metabolic process GO:0010565 66 0.998
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.998
Zebrafish Fly
positive regulation of ubiquitin protein transferase activity GO:0051443 4 0.998
negative regulation of molecular function GO:0044092 258 0.998
Mouse Fly
response to drug GO:0042493 75 0.997
b cell activation GO:0042113 161 0.997
protein processing GO:0016485 163 0.997
stem cell maintenance GO:0019827 130 0.997
apoptotic mitochondrial changes GO:0008637 48 0.997
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.997
negative regulation of map kinase activity GO:0043407 34 0.997
Mouse
mammary gland involution GO:0060056 9 0.997
chromatin organization GO:0006325 206 0.997
telomere maintenance GO:0000723 19 0.997
negative regulation of intracellular protein transport GO:0090317 27 0.997
Fly
negative regulation of cellular protein catabolic process GO:1903363 22 0.997
leukocyte differentiation GO:0002521 342 0.997
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.997
reactive oxygen species metabolic process GO:0072593 84 0.997
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.996
Zebrafish Fly
positive regulation of mitotic cell cycle GO:0045931 41 0.996
negative regulation of reactive oxygen species metabolic process GO:2000378 10 0.996
mitotic sister chromatid separation GO:0051306 9 0.996
b cell apoptotic process GO:0001783 19 0.996
positive regulation of chromosome segregation GO:0051984 4 0.996
regulation of chromatin modification GO:1903308 57 0.996
pigmentation GO:0043473 71 0.996
positive regulation of melanocyte differentiation GO:0045636 5 0.996
negative regulation of protein catabolic process GO:0042177 36 0.996
positive regulation of dna biosynthetic process GO:2000573 4 0.996
cerebrospinal fluid secretion GO:0033326 4 0.996
Mouse
positive regulation of neuron apoptotic process GO:0043525 25 0.995
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.995
cellular response to abiotic stimulus GO:0071214 56 0.995
response to oxidative stress GO:0006979 123 0.995
dendrite regeneration GO:0031104 1 0.995
regulation of cellular amino acid metabolic process GO:0006521 5 0.995
regulation of protein catabolic process GO:0042176 108 0.995
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.995
response to decreased oxygen levels GO:0036293 59 0.995
Human Zebrafish Worm
negative regulation of phosphorus metabolic process GO:0010563 184 0.995
Mouse Fly
negative regulation of apoptotic signaling pathway GO:2001234 104 0.995
positive regulation of cell cycle process GO:0090068 61 0.995
negative regulation of lipid kinase activity GO:0090219 1 0.995
Fly
lymphocyte homeostasis GO:0002260 64 0.995
lymphocyte differentiation GO:0030098 242 0.995
gland development GO:0048732 330 0.995
Mouse
ovarian follicle development GO:0001541 40 0.995
negative regulation of cellular amine metabolic process GO:0033239 1 0.995
protein ubiquitination GO:0016567 171 0.995
negative regulation of leukocyte differentiation GO:1902106 51 0.995
cell fate commitment GO:0045165 210 0.995
regulation of apoptotic signaling pathway GO:2001233 197 0.995
protein localization to organelle GO:0033365 185 0.995
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.994
protein autophosphorylation GO:0046777 61 0.994
cellular response to x ray GO:0071481 2 0.994
Fly
protein localization to nucleus GO:0034504 121 0.994
regulation of wnt signaling pathway GO:0030111 123 0.994
appendage morphogenesis GO:0035107 149 0.994
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.994
Mouse
regulation of mitosis GO:0007088 29 0.994
stem cell differentiation GO:0048863 268 0.994
Fly
cellular response to nutrient levels GO:0031669 64 0.993
metencephalon development GO:0022037 89 0.993
regulation of myeloid leukocyte differentiation GO:0002761 58 0.993
morphogenesis of a branching epithelium GO:0061138 193 0.993
Mouse
t cell lineage commitment GO:0002360 13 0.993
positive regulation of endopeptidase activity GO:0010950 43 0.993
Zebrafish Fly
negative regulation of organelle organization GO:0010639 90 0.993
negative regulation of organ growth GO:0046621 17 0.993
regulation of cytoplasmic transport GO:1903649 112 0.993
Fly
regulation of cell division GO:0051302 76 0.992
Zebrafish Mouse
signal transduction in absence of ligand GO:0038034 55 0.992
regulation of epidermal cell division GO:0010482 3 0.992
Mouse
regulation of cellular catabolic process GO:0031329 242 0.992
regulation of microtubule polymerization GO:0031113 7 0.992
regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902229 14 0.992
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.992
Mouse Fly
histone deacetylation GO:0016575 26 0.992
positive regulation of cell development GO:0010720 237 0.991
regulation of intracellular transport GO:0032386 159 0.991
Fly
activation of anaphase promoting complex activity GO:0051488 1 0.991
response to hypoxia GO:0001666 58 0.991
Human Zebrafish Worm
mesonephric tubule development GO:0072164 94 0.991
negative regulation of cell aging GO:0090344 5 0.991
axon guidance GO:0007411 141 0.991
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.990
negative regulation of jun kinase activity GO:0043508 9 0.990
Mouse
organ growth GO:0035265 117 0.990
Fly
regulation of autophagy GO:0010506 30 0.990
t cell differentiation in thymus GO:0033077 77 0.990
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.990
Human Mouse
response to purine containing compound GO:0014074 28 0.990
regulation of protein localization GO:0032880 231 0.989
Fly
negative regulation of stem cell proliferation GO:2000647 12 0.989
protein modification by small protein conjugation GO:0032446 187 0.989
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.989
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.989
regulation of transcription factor import into nucleus GO:0042990 24 0.989
Fly
axonogenesis GO:0007409 274 0.989
positive regulation of programmed cell death GO:0043068 218 0.989
hematopoietic progenitor cell differentiation GO:0002244 143 0.989
positive regulation of fibroblast proliferation GO:0048146 20 0.988
hair follicle morphogenesis GO:0031069 29 0.988
Mouse
protein maturation GO:0051604 176 0.988
negative regulation of kinase activity GO:0033673 81 0.988
Mouse Fly
nuclear transport GO:0051169 139 0.988
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.988
wnt signaling pathway GO:0016055 188 0.988
positive regulation of protein modification process GO:0031401 299 0.988
ectopic germ cell programmed cell death GO:0035234 9 0.988
Fly
negative regulation of mapk cascade GO:0043409 65 0.988
Mouse
regulation of endopeptidase activity GO:0052548 89 0.987
Zebrafish Mouse Fly
epithelial tube morphogenesis GO:0060562 303 0.986
lymphocyte apoptotic process GO:0070227 54 0.986
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.986
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.986
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.986
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.986
protein import into nucleus GO:0006606 95 0.985
negative regulation of cell growth GO:0030308 44 0.985
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.985
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.985
pallium development GO:0021543 120 0.985
Mouse
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.984
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.984
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.984
appendage development GO:0048736 166 0.984
Mouse
cellular response to starvation GO:0009267 57 0.984
response to amino acid GO:0043200 37 0.983
neuroepithelial cell differentiation GO:0060563 37 0.983
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.983
t cell apoptotic process GO:0070231 39 0.983
negative regulation of cellular catabolic process GO:0031330 47 0.983
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.983
regeneration GO:0031099 38 0.983
Fly
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 3 0.982
ossification GO:0001503 216 0.982
cellular response to external stimulus GO:0071496 88 0.982
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.982
negative regulation of nuclear division GO:0051784 19 0.982
germ cell development GO:0007281 185 0.981
Fly
response to organic cyclic compound GO:0014070 198 0.981
regulation of histone modification GO:0031056 56 0.981
negative regulation of protein maturation GO:1903318 79 0.981
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.981
Fly
cellular response to peptide GO:1901653 92 0.980
positive regulation of neuron death GO:1901216 28 0.980
positive regulation of organelle organization GO:0010638 128 0.980
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.980
Human
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.980
t cell homeostasis GO:0043029 35 0.980
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.980
regulation of b cell differentiation GO:0045577 23 0.979
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.979
regulation of organelle organization GO:0033043 289 0.979
regulation of lymphocyte proliferation GO:0050670 117 0.979
cell division GO:0051301 120 0.979
Zebrafish Mouse
negative regulation of leukocyte proliferation GO:0070664 46 0.979
b cell differentiation GO:0030183 78 0.979
response to uv GO:0009411 44 0.979
regulation of protein targeting GO:1903533 61 0.978
Fly
negative regulation of t cell proliferation GO:0042130 38 0.978
positive regulation of wnt signaling pathway GO:0030177 45 0.978
regulation of pigment cell differentiation GO:0050932 7 0.978
response to alkaloid GO:0043279 34 0.978
protein deacetylation GO:0006476 32 0.977
macromolecule catabolic process GO:0009057 281 0.977
positive regulation of mitosis GO:0045840 14 0.976
sphingolipid metabolic process GO:0006665 45 0.976
muscle cell differentiation GO:0042692 261 0.976
negative regulation of glial cell proliferation GO:0060253 4 0.976
negative regulation of transferase activity GO:0051348 85 0.976
Mouse Fly
erythrocyte differentiation GO:0030218 88 0.976
positive regulation of cellular protein catabolic process GO:1903364 34 0.976
camera type eye development GO:0043010 266 0.975
response to organonitrogen compound GO:0010243 246 0.975
regulation of myeloid cell apoptotic process GO:0033032 19 0.974
regulation of lymphocyte apoptotic process GO:0070228 41 0.974
regulation of neural precursor cell proliferation GO:2000177 70 0.974
osteoblast development GO:0002076 17 0.973
negative regulation of immature t cell proliferation GO:0033087 3 0.973
zymogen activation GO:0031638 41 0.973
Fly
response to uv b GO:0010224 5 0.973
regulation of smad protein import into nucleus GO:0060390 3 0.973
regulation of histone deacetylation GO:0031063 12 0.972
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.972
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.972
response to reactive oxygen species GO:0000302 56 0.972
regulation of mitotic sister chromatid segregation GO:0033047 12 0.972
positive regulation of cellular component biogenesis GO:0044089 94 0.971
Human
negative regulation of osteoblast proliferation GO:0033689 4 0.971
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.971
embryonic organ morphogenesis GO:0048562 276 0.971
homeostasis of number of cells GO:0048872 210 0.971
regulation of developmental pigmentation GO:0048070 14 0.971
protection from non homologous end joining at telomere GO:0031848 4 0.970
chromosome separation GO:0051304 14 0.969
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.968
regulation of hippo signaling GO:0035330 1 0.968
negative regulation of intracellular transport GO:0032387 38 0.968
Fly
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.968
regulation of lipid kinase activity GO:0043550 14 0.968
Fly
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.967
phospholipid dephosphorylation GO:0046839 6 0.967
anatomical structure homeostasis GO:0060249 145 0.967
Zebrafish
regulation of dna templated transcription in response to stress GO:0043620 9 0.967
Fly
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.967
development of primary sexual characteristics GO:0045137 143 0.966
negative regulation of chromosome organization GO:2001251 30 0.966
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.966
histone h3 acetylation GO:0043966 14 0.966
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903378 3 0.965
positive regulation of cell death GO:0010942 224 0.965
mammary gland morphogenesis GO:0060443 54 0.965
regulation of osteoblast differentiation GO:0045667 67 0.965
regulation of nuclear cell cycle dna replication GO:0033262 2 0.964
neuron projection guidance GO:0097485 141 0.964
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 14 0.963
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051439 1 0.963
histone modification GO:0016570 159 0.963
cell growth GO:0016049 130 0.962
Human
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 4 0.962
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.962
protein deacylation GO:0035601 36 0.962
response to corticosteroid GO:0031960 20 0.960
protein stabilization GO:0050821 25 0.960
mitochondrial membrane organization GO:0007006 26 0.960
positive regulation of smooth muscle cell migration GO:0014911 4 0.959
positive regulation of response to dna damage stimulus GO:2001022 14 0.959
Mouse
nuclear division GO:0000280 158 0.959
Worm Fly
mitochondrion degradation GO:0000422 3 0.959
liposaccharide metabolic process GO:1903509 27 0.958
negative regulation of homeostatic process GO:0032845 71 0.958
positive t cell selection GO:0043368 23 0.957
intra s dna damage checkpoint GO:0031573 4 0.957
oocyte differentiation GO:0009994 35 0.957
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.957
cellular response to amino acid stimulus GO:0071230 29 0.957
regulation of sister chromatid segregation GO:0033045 13 0.956
meiotic cell cycle GO:0051321 122 0.955
Worm Fly
photoreceptor cell morphogenesis GO:0008594 3 0.955
cellular response to lipid GO:0071396 145 0.955
bone development GO:0060348 120 0.955
programmed necrotic cell death GO:0097300 28 0.954
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.954
negative regulation of protein import into nucleus GO:0042308 21 0.953
Fly
regulation of protein localization to nucleus GO:1900180 60 0.953
Fly
regulation of protein import into nucleus GO:0042306 52 0.952
Fly
negative regulation of neuron death GO:1901215 98 0.952
Mouse
stem cell development GO:0048864 219 0.952
positive regulation of cell cycle arrest GO:0071158 10 0.951
rhythmic process GO:0048511 174 0.951
response to hyperoxia GO:0055093 2 0.951
cellular lipid metabolic process GO:0044255 323 0.951
Fly
modulation by virus of host morphology or physiology GO:0019048 3 0.951
regulation of chromosome segregation GO:0051983 21 0.950
positive regulation of transcription by galactose GO:0000411 1 0.950
microtubule polymerization GO:0046785 12 0.950
female genitalia morphogenesis GO:0048807 3 0.949
Mouse
negative regulation of transcription factor import into nucleus GO:0042992 13 0.949
Fly
positive regulation of growth GO:0045927 104 0.948
Fly
positive regulation of b cell apoptotic process GO:0002904 4 0.948
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.947
Mouse
dna repair GO:0006281 107 0.947
embryonic skeletal system development GO:0048706 120 0.947
positive regulation of notch signaling pathway GO:0045747 18 0.947
Mouse
thymocyte apoptotic process GO:0070242 19 0.946
regulation of cell aging GO:0090342 9 0.946
developmental programmed cell death GO:0010623 41 0.946
Fly
inositol phosphate catabolic process GO:0071545 4 0.946
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 4 0.945
cellular amino acid metabolic process GO:0006520 103 0.945
negative regulation of cell substrate adhesion GO:0010812 16 0.945
regulation of nuclear division GO:0051783 56 0.945
digestive tract development GO:0048565 190 0.944
spermatogenesis GO:0007283 284 0.944
Zebrafish
positive regulation of microtubule polymerization GO:0031116 3 0.944
regulation of smooth muscle cell migration GO:0014910 6 0.944
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.944
Fly
jak stat cascade GO:0007259 42 0.942
oogenesis GO:0048477 56 0.941
Fly
t cell homeostatic proliferation GO:0001777 4 0.941
female gamete generation GO:0007292 74 0.941
Fly
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.941
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.940
t cell differentiation GO:0030217 174 0.939
developmental pigmentation GO:0048066 40 0.939
positive regulation of kinase activity GO:0033674 155 0.938
response to increased oxygen levels GO:0036296 2 0.938
positive regulation of ossification GO:0045778 47 0.937
double strand break repair via nonhomologous end joining GO:0006303 10 0.937
cellular amide metabolic process GO:0043603 58 0.937
activation of mapkk activity GO:0000186 15 0.937
chromatin mediated maintenance of transcription GO:0048096 2 0.936
canonical wnt signaling pathway involved in positive regulation of apoptotic process GO:0044337 3 0.936
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.936
telomere maintenance via telomerase GO:0007004 1 0.936
response to hydrogen peroxide GO:0042542 32 0.935
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.935
cellular response to peptide hormone stimulus GO:0071375 92 0.934
mitotic spindle assembly checkpoint GO:0007094 7 0.933
regulation of myeloid cell differentiation GO:0045637 96 0.933
negative regulation of cellular component organization GO:0051129 194 0.932
microtubule polymerization or depolymerization GO:0031109 26 0.932
tissue regeneration GO:0042246 22 0.931
Fly
cellular ketone metabolic process GO:0042180 84 0.931
regulation of cytoskeleton organization GO:0051493 122 0.930
cardiac endothelial cell differentiation GO:0003348 4 0.930
regulation of protein serine threonine kinase activity GO:0071900 157 0.930
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.930
positive regulation of pigment cell differentiation GO:0050942 5 0.929
mitochondrion organization GO:0007005 134 0.929
mitochondrial transport GO:0006839 36 0.928
regulation of cellular senescence GO:2000772 6 0.927
connective tissue development GO:0061448 179 0.925

Trp53 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 1.000
Human
cancer DOID:162 0 1.000
Human
organ system cancer DOID:0050686 0 1.000
Human
endocrine gland cancer DOID:170 0 1.000
Human
large intestine cancer DOID:5672 0 0.998
Human
colon cancer DOID:219 0 0.998
Human
gastrointestinal system cancer DOID:3119 0 0.998
Human
intestinal cancer DOID:10155 0 0.998
Human
colorectal cancer DOID:9256 0 0.998
Human
immune system cancer DOID:0060083 0 0.995
hematologic cancer DOID:2531 0 0.995
thyroid cancer DOID:1781 0 0.992
nervous system cancer DOID:3093 0 0.986
central nervous system cancer DOID:3620 0 0.986
pancreatic cancer DOID:1793 0 0.974
Human
prostate cancer DOID:10283 0 0.931
male reproductive organ cancer DOID:3856 0 0.931
reproductive organ cancer DOID:193 0 0.931