Mus musculus

295 known processes

Trp63

transformation related protein 63

(Aliases: MGC115972,P63,P51/P63,Tp63,AI462811,P73l,Ket,Trp53rp1)

Trp63 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female genitalia morphogenesis GO:0048807 3 1.000
gland development GO:0048732 330 0.999
negative regulation of epithelial cell proliferation GO:0050680 64 0.998
keratinocyte differentiation GO:0030216 48 0.995
epithelial cell proliferation GO:0050673 174 0.990
regulation of epithelial cell proliferation GO:0050678 141 0.990
renal system development GO:0072001 225 0.988
hair follicle morphogenesis GO:0031069 29 0.987
camera type eye development GO:0043010 266 0.985
negative regulation of cell proliferation GO:0008285 296 0.985
Mouse
branching involved in salivary gland morphogenesis GO:0060445 26 0.976
regulation of branching involved in salivary gland morphogenesis GO:0060693 11 0.974
neuron projection guidance GO:0097485 141 0.973
keratinocyte proliferation GO:0043616 21 0.970
salivary gland cavitation GO:0060662 5 0.966
embryonic organ morphogenesis GO:0048562 276 0.966
regulation of cardiac muscle cell proliferation GO:0060043 23 0.966
skin morphogenesis GO:0043589 38 0.965
embryonic skeletal system development GO:0048706 120 0.964
urogenital system development GO:0001655 261 0.962
genitalia morphogenesis GO:0035112 11 0.962
morphogenesis of a branching epithelium GO:0061138 193 0.960
regulation of epidermal cell differentiation GO:0045604 21 0.959
striated muscle tissue development GO:0014706 293 0.956
formation of radial glial scaffolds GO:0021943 4 0.954
regulation of cell size GO:0008361 72 0.952
Mouse
pallium development GO:0021543 120 0.952
Mouse
glial cell differentiation GO:0010001 131 0.951
negative regulation of keratinocyte differentiation GO:0045617 4 0.950
epithelial cell development GO:0002064 159 0.946
regulation of muscle tissue development GO:1901861 97 0.943
salivary gland development GO:0007431 37 0.942
chemotaxis GO:0006935 247 0.941
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.940
Mouse
negative regulation of epidermis development GO:0045683 9 0.940
tube lumen cavitation GO:0060605 5 0.939
stem cell development GO:0048864 219 0.938
hindbrain development GO:0030902 128 0.936
Mouse
salivary gland morphogenesis GO:0007435 33 0.936
kidney development GO:0001822 213 0.934
axonogenesis GO:0007409 274 0.934
ear development GO:0043583 200 0.933
epithelial cell morphogenesis GO:0003382 41 0.931
embryonic appendage morphogenesis GO:0035113 126 0.928
single organism nuclear import GO:1902593 95 0.926
Mouse Fly
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.919
Mouse
stem cell maintenance GO:0019827 130 0.919
male sex differentiation GO:0046661 109 0.919
axon guidance GO:0007411 141 0.918
regulation of water loss via skin GO:0033561 16 0.913
t cell activation GO:0042110 289 0.913
Mouse
cellular response to extracellular stimulus GO:0031668 81 0.911
Mouse Fly
regulation of heart growth GO:0060420 31 0.909
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.906
embryonic limb morphogenesis GO:0030326 126 0.905
nuclear transport GO:0051169 139 0.904
Mouse Fly
limb development GO:0060173 166 0.904
t cell activation involved in immune response GO:0002286 43 0.903
Mouse
regulation of protein processing GO:0070613 96 0.896
Mouse
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.896
Mouse
smooth muscle tissue development GO:0048745 22 0.893
morphogenesis of an epithelial fold GO:0060571 28 0.890
regulation of cardiac muscle tissue development GO:0055024 31 0.889
mitotic g1 dna damage checkpoint GO:0031571 4 0.888
Mouse
odontogenesis GO:0042476 78 0.883
digestive system development GO:0055123 200 0.883
ear morphogenesis GO:0042471 118 0.879
appendage morphogenesis GO:0035107 149 0.870
appendage development GO:0048736 166 0.868
response to growth factor GO:0070848 198 0.866
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.866
regulation of cell division GO:0051302 76 0.862
neuron projection extension GO:1990138 64 0.862
negative regulation of proteolysis GO:0045861 74 0.859
Mouse
digestive tract morphogenesis GO:0048546 147 0.859
epidermis development GO:0008544 187 0.848
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.847
Mouse
sensory organ morphogenesis GO:0090596 242 0.846
regulation of axon extension GO:0030516 43 0.845
multicellular organismal water homeostasis GO:0050891 23 0.844
bmp signaling pathway GO:0030509 93 0.841
neuroblast differentiation GO:0014016 2 0.841
Fly
gastrulation GO:0007369 116 0.837
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.835
hippocampus development GO:0021766 52 0.835
Mouse
regulation of protein kinase activity GO:0045859 232 0.833
Mouse
autonomic nervous system development GO:0048483 43 0.829
regionalization GO:0003002 337 0.827
gliogenesis GO:0042063 141 0.827
muscle cell differentiation GO:0042692 261 0.826
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.826
Mouse
lung induction GO:0060492 3 0.821
cellular response to growth factor stimulus GO:0071363 197 0.821
Mouse
prostate gland morphogenesis GO:0060512 32 0.820
cellular response to external stimulus GO:0071496 88 0.820
Mouse Fly
organ growth GO:0035265 117 0.806
Fly
nuclear import GO:0051170 95 0.805
Mouse Fly
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.801
cell cell signaling involved in lung development GO:0060495 1 0.801
somatic stem cell maintenance GO:0035019 47 0.796
embryonic skeletal system morphogenesis GO:0048704 91 0.793
positive regulation of neuron apoptotic process GO:0043525 25 0.792
Mouse
limb morphogenesis GO:0035108 149 0.791
regulation of cardiac muscle tissue growth GO:0055021 26 0.786
apoptotic signaling pathway GO:0097190 306 0.786
prostatic bud formation GO:0060513 10 0.781
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.780
small gtpase mediated signal transduction GO:0007264 97 0.779
covalent chromatin modification GO:0016569 163 0.778
Mouse
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.778
Mouse
embryonic genitalia morphogenesis GO:0030538 4 0.771
leukocyte proliferation GO:0070661 172 0.770
Mouse
positive regulation of fat cell proliferation GO:0070346 1 0.767
embryonic placenta development GO:0001892 98 0.765
regulation of mesenchymal cell proliferation GO:0010464 37 0.761
exocrine system development GO:0035272 45 0.758
renal vesicle induction GO:0072034 3 0.754
lung cell differentiation GO:0060479 30 0.749
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.749
Fly
branching morphogenesis of an epithelial tube GO:0048754 159 0.748
regulation of mapk cascade GO:0043408 248 0.746
Mouse
water homeostasis GO:0030104 27 0.745
response to extracellular stimulus GO:0009991 127 0.743
Mouse Worm Fly
odontogenesis of dentin containing tooth GO:0042475 66 0.741
skin development GO:0043588 220 0.739
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.739
cerebral cortex neuron differentiation GO:0021895 19 0.729
epidermis morphogenesis GO:0048730 33 0.728
skeletal muscle organ development GO:0060538 163 0.726
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.718
Fly
lymphocyte proliferation GO:0046651 164 0.715
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.710
positive regulation of cell cycle GO:0045787 92 0.710
Human Mouse Fly
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 8 0.708
Fly
rrna transcription GO:0009303 9 0.704
Mouse
molting cycle GO:0042303 90 0.701
regulation of epidermis development GO:0045682 33 0.699
negative regulation of jun kinase activity GO:0043508 9 0.698
Mouse
forebrain neuron fate commitment GO:0021877 13 0.696
nucleocytoplasmic transport GO:0006913 139 0.694
Mouse Fly
chromatin organization GO:0006325 206 0.692
lateral sprouting from an epithelium GO:0060601 13 0.688
palate development GO:0060021 76 0.687
mammary gland bud formation GO:0060615 2 0.687
sensory perception GO:0007600 245 0.687
cardiac muscle tissue development GO:0048738 130 0.685
cellular response to cytokine stimulus GO:0071345 189 0.684
axis elongation involved in somitogenesis GO:0090245 4 0.681
prostate gland development GO:0030850 48 0.680
regulation of nucleocytoplasmic transport GO:0046822 73 0.679
Fly
cell growth GO:0016049 130 0.679
forebrain development GO:0030900 302 0.678
Mouse
positive regulation of growth GO:0045927 104 0.675
Fly
cell aging GO:0007569 35 0.675
fat cell differentiation GO:0045444 160 0.675
cerebrospinal fluid secretion GO:0033326 4 0.674
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.670
Mouse
t cell differentiation in thymus GO:0033077 77 0.662
Mouse
cell proliferation in hindbrain GO:0021534 10 0.661
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.660
tissue regeneration GO:0042246 22 0.658
Fly
placenta development GO:0001890 140 0.654
female genitalia development GO:0030540 14 0.650
regulation of protein targeting GO:1903533 61 0.648
Fly
cloacal septation GO:0060197 2 0.648
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.647
positive regulation of lymphocyte activation GO:0051251 140 0.644
regulation of protein import into nucleus GO:0042306 52 0.642
Fly
stem cell differentiation GO:0048863 268 0.639
Fly
cellular response to dna damage stimulus GO:0006974 207 0.637
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.634
chromatin modification GO:0016568 187 0.633
regulation of lymphocyte activation GO:0051249 240 0.629
inner ear morphogenesis GO:0042472 101 0.624
sensory perception of sound GO:0007605 97 0.623
endodermal cell fate specification GO:0001714 4 0.620
prostate gland epithelium morphogenesis GO:0060740 31 0.617
prostate glandular acinus development GO:0060525 12 0.614
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.613
regulation of organ growth GO:0046620 61 0.612
Fly
digestive tract development GO:0048565 190 0.607
mammary gland epithelium development GO:0061180 65 0.605
muscle system process GO:0003012 141 0.602
extrinsic apoptotic signaling pathway GO:0097191 126 0.601
cell adhesion GO:0007155 329 0.600
protein localization to plasma membrane GO:0072659 57 0.598
negative regulation of protein modification process GO:0031400 163 0.591
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.588
dna metabolic process GO:0006259 303 0.577
Mouse Fly
positive regulation of protein modification process GO:0031401 299 0.577
Mouse
regulation of transcription factor import into nucleus GO:0042990 24 0.575
Fly
canonical wnt signaling pathway GO:0060070 130 0.573
angiogenesis GO:0001525 201 0.573
positive regulation of cell aging GO:0090343 1 0.572
Mouse
t cell differentiation GO:0030217 174 0.571
Mouse
regeneration GO:0031099 38 0.569
Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.563
negative regulation of reactive oxygen species metabolic process GO:2000378 10 0.560
Mouse
protein acylation GO:0043543 64 0.558
semicircular canal fusion GO:0060879 1 0.557
male gonad development GO:0008584 88 0.556
histone h3 acetylation GO:0043966 14 0.553
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.552
protein localization to organelle GO:0033365 185 0.551
Mouse Fly
negative regulation of cytokine production GO:0001818 84 0.547
negative regulation of protein maturation GO:1903318 79 0.545
Mouse
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.540
positive regulation of axon extension GO:0045773 20 0.539
regulation of organ morphogenesis GO:2000027 144 0.536
lung proximal distal axis specification GO:0061115 1 0.535
cellular amine metabolic process GO:0044106 44 0.535
cellular response to radiation GO:0071478 28 0.535
Mouse Fly
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.531
blood vessel morphogenesis GO:0048514 285 0.529
regulation of intracellular protein transport GO:0033157 82 0.527
Fly
keratinocyte development GO:0003334 10 0.525
cell fate commitment GO:0045165 210 0.520
Mouse
regulation of kinase activity GO:0043549 249 0.515
Mouse Fly
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.513
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.511
regulation of neuron differentiation GO:0045664 281 0.510
Fly
leukocyte differentiation GO:0002521 342 0.507
Mouse
tongue development GO:0043586 18 0.506
mapk cascade GO:0000165 281 0.498
Mouse
pericardium development GO:0060039 16 0.497
cardiac muscle cell proliferation GO:0060038 31 0.494
branch elongation involved in salivary gland morphogenesis GO:0060667 2 0.491
central nervous system neuron differentiation GO:0021953 162 0.491
regulation of keratinocyte differentiation GO:0045616 11 0.490
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.489
establishment or maintenance of neuroblast polarity GO:0045196 1 0.489
programmed necrotic cell death GO:0097300 28 0.488
Mouse
regulation of cell growth GO:0001558 91 0.488
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.488
establishment of skin barrier GO:0061436 14 0.488
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.483
Mouse
columnar cuboidal epithelial cell development GO:0002066 29 0.481
regulation of cell activation GO:0050865 289 0.481
heart growth GO:0060419 45 0.479
histone modification GO:0016570 159 0.477
Mouse
negative regulation of protein processing GO:0010955 79 0.472
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.469
Mouse
hepatocyte apoptotic process GO:0097284 11 0.468
positive regulation of protein phosphorylation GO:0001934 242 0.466
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.465
Mouse
morphogenesis of a polarized epithelium GO:0001738 37 0.465
regulation of body fluid levels GO:0050878 162 0.463
muscle tissue development GO:0060537 308 0.462
determination of heart left right asymmetry GO:0061371 48 0.461
submandibular salivary gland formation GO:0060661 1 0.459
regulation of proteolysis GO:0030162 164 0.457
metanephric nephron tubule formation GO:0072289 4 0.456
regulation of cell cycle GO:0051726 281 0.454
Human Mouse Fly
forebrain neuron differentiation GO:0021879 52 0.453
multicellular organismal homeostasis GO:0048871 164 0.449
male genitalia development GO:0030539 20 0.448
leukocyte activation involved in immune response GO:0002366 126 0.445
Mouse
nephron development GO:0072006 109 0.445
protein import into nucleus GO:0006606 95 0.444
Mouse Fly
asymmetric neuroblast division GO:0055059 1 0.438
protein modification by small protein conjugation GO:0032446 187 0.431
otic placode formation GO:0043049 1 0.431
forebrain generation of neurons GO:0021872 63 0.430
t cell lineage commitment GO:0002360 13 0.426
Mouse
regulation of tissue remodeling GO:0034103 38 0.423
Mouse
positive regulation of white fat cell proliferation GO:0070352 1 0.422
hematopoietic progenitor cell differentiation GO:0002244 143 0.420
cell cycle arrest GO:0007050 37 0.420
Mouse
mitochondrial dna repair GO:0043504 3 0.419
Mouse
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.419
midgut development GO:0007494 4 0.418
hair follicle development GO:0001942 85 0.415
primary prostatic bud elongation GO:0060516 2 0.414
establishment of protein localization to organelle GO:0072594 118 0.412
Mouse Fly
cell fate specification GO:0001708 72 0.411
development of primary sexual characteristics GO:0045137 143 0.411
developmental cell growth GO:0048588 84 0.409
morphogenesis of embryonic epithelium GO:0016331 159 0.406
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.405
wnt signaling pathway GO:0016055 188 0.402
respiratory system development GO:0060541 190 0.401
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.401
brown fat cell differentiation GO:0050873 36 0.401
cardiac right atrium morphogenesis GO:0003213 3 0.400
regulation of neuron apoptotic process GO:0043523 122 0.398
Mouse
protein localization to nucleus GO:0034504 121 0.398
Mouse Fly
regulation of neural precursor cell proliferation GO:2000177 70 0.398
Mouse
trophectodermal cell differentiation GO:0001829 21 0.396
regulation of histone modification GO:0031056 56 0.393
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.391
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.385
central nervous system vasculogenesis GO:0022009 3 0.385
regulation of protein maturation GO:1903317 96 0.385
Mouse
microtubule polymerization or depolymerization GO:0031109 26 0.384
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.383
Fly
regulation of t cell differentiation GO:0045580 83 0.383
negative regulation of protein import into nucleus GO:0042308 21 0.381
Fly
negative regulation of endopeptidase activity GO:0010951 44 0.378
regulation of stem cell differentiation GO:2000736 50 0.377
carboxylic acid biosynthetic process GO:0046394 86 0.373
b cell proliferation GO:0042100 53 0.373
g1 s transition of mitotic cell cycle GO:0000082 57 0.369
Mouse
forebrain radial glial cell differentiation GO:0021861 4 0.368
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.367
Mouse
morphogenesis of an epithelial sheet GO:0002011 27 0.367
bone morphogenesis GO:0060349 78 0.367
positive regulation of apoptotic signaling pathway GO:2001235 95 0.361
regulation of protein serine threonine kinase activity GO:0071900 157 0.359
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.356
Mouse
neuron migration GO:0001764 122 0.356
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.355
Mouse
establishment of tissue polarity GO:0007164 28 0.354
cardiac chamber development GO:0003205 108 0.354
regulation of reproductive process GO:2000241 66 0.354
negative regulation of cell cycle GO:0045786 123 0.352
Mouse
male genitalia morphogenesis GO:0048808 4 0.350
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.348
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.346
female sex differentiation GO:0046660 84 0.346
heart morphogenesis GO:0003007 178 0.345
negative regulation of protein metabolic process GO:0051248 282 0.345
Mouse
protein processing GO:0016485 163 0.345
Mouse Fly
neuroblast division GO:0055057 10 0.345
cell type specific apoptotic process GO:0097285 268 0.344
establishment of planar polarity GO:0001736 28 0.341
embryonic epithelial tube formation GO:0001838 130 0.340
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.339
establishment of neuroblast polarity GO:0045200 1 0.338
male anatomical structure morphogenesis GO:0090598 4 0.338
meiotic cell cycle GO:0051321 122 0.336
Worm Fly
fibroblast proliferation GO:0048144 35 0.336
Mouse
stem cell proliferation GO:0072089 117 0.334
morphogenesis of an epithelial bud GO:0060572 18 0.333
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.332
anatomical structure homeostasis GO:0060249 145 0.329
negative regulation of histone h3 k9 methylation GO:0051573 4 0.328
cellular response to starvation GO:0009267 57 0.327
Mouse Fly
mesenchymal epithelial cell signaling involved in lung development GO:0060496 1 0.326
positive regulation of organ growth GO:0046622 29 0.326
neuronal action potential GO:0019228 54 0.322
lung development GO:0030324 164 0.321
cell division GO:0051301 120 0.321
positive regulation of t cell apoptotic process GO:0070234 8 0.321
Mouse
midbrain hindbrain boundary maturation GO:0021732 1 0.320
regulation of white fat cell proliferation GO:0070350 2 0.319
white fat cell proliferation GO:0070343 2 0.316
cardiac muscle tissue growth GO:0055017 37 0.315
negative regulation of intracellular protein transport GO:0090317 27 0.314
Fly
face morphogenesis GO:0060325 29 0.314
negative regulation of cardiac muscle tissue development GO:0055026 8 0.314
kidney morphogenesis GO:0060993 83 0.312
microtubule cytoskeleton organization GO:0000226 157 0.311
metanephric nephron epithelium development GO:0072243 19 0.310
regulation of morphogenesis of a branching structure GO:0060688 53 0.309
nephric duct formation GO:0072179 4 0.309
positive regulation of thymocyte apoptotic process GO:0070245 5 0.308
Mouse
chondrocyte differentiation GO:0002062 72 0.308
cell differentiation involved in embryonic placenta development GO:0060706 26 0.308
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 2 0.305
regulation of cysteine type endopeptidase activity GO:2000116 65 0.304
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.303
harderian gland development GO:0070384 2 0.302
outflow tract morphogenesis GO:0003151 53 0.302
mesenchymal cell differentiation involved in lung development GO:0060915 2 0.301
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.300
oxidation reduction process GO:0055114 342 0.300
mammary placode formation GO:0060596 4 0.299
cardiac muscle cell differentiation GO:0055007 69 0.298
intrinsic apoptotic signaling pathway GO:0097193 132 0.297
response to radiation GO:0009314 165 0.297
Mouse Fly
regulation of anatomical structure size GO:0090066 178 0.295
Mouse
bronchiole development GO:0060435 3 0.295
dendrite development GO:0016358 115 0.295
diencephalon development GO:0021536 63 0.293
positive regulation of notch signaling pathway GO:0045747 18 0.293
microtubule based process GO:0007017 236 0.291
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.291
response to ionizing radiation GO:0010212 42 0.290
Mouse Fly
cellular ketone metabolic process GO:0042180 84 0.289
endocytosis GO:0006897 168 0.286
skeletal muscle cell differentiation GO:0035914 66 0.283
epithelial tube formation GO:0072175 130 0.282
lymphocyte differentiation GO:0030098 242 0.281
Mouse
regulation of neuron projection development GO:0010975 169 0.280
neural crest cell development GO:0014032 48 0.279
skeletal system development GO:0001501 356 0.276
protein catabolic process GO:0030163 221 0.275
cellular response to acid chemical GO:0071229 68 0.274
intracellular protein transport GO:0006886 204 0.274
Mouse Fly
regulation of fibroblast proliferation GO:0048145 34 0.272
Mouse
single fertilization GO:0007338 82 0.272
nail development GO:0035878 5 0.272
sympathetic nervous system development GO:0048485 22 0.271
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.269
Mouse
peptidyl amino acid modification GO:0018193 336 0.269
Mouse
regulation of bmp signaling pathway GO:0030510 60 0.268
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.266
cell cycle checkpoint GO:0000075 47 0.266
Mouse
intestinal epithelial cell development GO:0060576 12 0.266
cellular lipid metabolic process GO:0044255 323 0.265
Fly
regulation of epidermal cell division GO:0010482 3 0.263
memory GO:0007613 58 0.261
signal transduction involved in dna damage checkpoint GO:0072422 3 0.258
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.258
limbic system development GO:0021761 72 0.257
Mouse
positive regulation of transferase activity GO:0051347 167 0.257
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.257
Mouse
negative regulation of nervous system development GO:0051961 156 0.255
Mouse Fly
urinary bladder development GO:0060157 5 0.254
forelimb morphogenesis GO:0035136 40 0.253
epithelial to mesenchymal transition GO:0001837 47 0.253
negative regulation of t cell differentiation GO:0045581 23 0.252
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.252
regulation of cell cycle process GO:0010564 160 0.251
Human Mouse
apoptotic process involved in patterning of blood vessels GO:1902262 6 0.250
keratinization GO:0031424 9 0.249
endothelial cell morphogenesis GO:0001886 9 0.248
protein methylation GO:0006479 81 0.247
somitogenesis GO:0001756 69 0.247
Mouse
cardiac epithelial to mesenchymal transition GO:0060317 18 0.246
schwann cell differentiation GO:0014037 26 0.245
negative regulation of immature t cell proliferation GO:0033087 3 0.244
regulation of cellular component biogenesis GO:0044087 181 0.243
negative regulation of nucleocytoplasmic transport GO:0046823 23 0.242
Fly
mesenchyme development GO:0060485 152 0.241
negative regulation of protein localization to nucleus GO:1900181 23 0.240
Fly
muscle contraction GO:0006936 101 0.239
learning or memory GO:0007611 148 0.239
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.238
intermediate filament based process GO:0045103 27 0.237
negative regulation of cardiac muscle cell proliferation GO:0060044 5 0.235
development of primary male sexual characteristics GO:0046546 88 0.235
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.235
Mouse
cell proliferation involved in kidney development GO:0072111 14 0.235
cellular protein complex assembly GO:0043623 116 0.234
granulocyte differentiation GO:0030851 17 0.233
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.233
chondrocyte hypertrophy GO:0003415 4 0.228
tube formation GO:0035148 140 0.227
mesonephric duct morphogenesis GO:0072180 4 0.227
sertoli cell differentiation GO:0060008 18 0.226
oocyte development GO:0048599 33 0.225
single organism cell adhesion GO:0098602 156 0.219
mammary gland bud morphogenesis GO:0060648 4 0.219
regulation of cardiac chamber formation GO:1901210 1 0.219
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.219
pigment metabolic process GO:0042440 32 0.219
negative regulation of dna replication GO:0008156 4 0.218
Mouse
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.217
transcription factor import into nucleus GO:0042991 26 0.217
Fly
positive regulation of cell development GO:0010720 237 0.215
regulation of hydrolase activity GO:0051336 246 0.215
post anal tail morphogenesis GO:0036342 23 0.215
respiratory tube development GO:0030323 167 0.214
immune effector process GO:0002252 321 0.214
Mouse
positive regulation of mapk cascade GO:0043410 170 0.212
inflammatory response GO:0006954 244 0.211
Mouse
positive regulation of heart growth GO:0060421 18 0.209
ventral spinal cord interneuron differentiation GO:0021514 16 0.209
optic nerve morphogenesis GO:0021631 6 0.209
mitotic cell cycle GO:0000278 195 0.209
Mouse
response to light stimulus GO:0009416 135 0.208
Mouse Fly
positive regulation of translation GO:0045727 19 0.208
apoptotic mitochondrial changes GO:0008637 48 0.207
Mouse
nuclear division GO:0000280 158 0.207
Worm Fly
blastocyst formation GO:0001825 33 0.207
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 20 0.206
metanephros development GO:0001656 79 0.204
radial glial cell differentiation GO:0060019 6 0.204
cardiac endothelial cell differentiation GO:0003348 4 0.203
intermediate filament cytoskeleton organization GO:0045104 26 0.203
cardiac ventricle morphogenesis GO:0003208 50 0.202
cd8 positive alpha beta t cell differentiation GO:0043374 9 0.202
developmental growth involved in morphogenesis GO:0060560 138 0.201
monocarboxylic acid metabolic process GO:0032787 191 0.200
mitochondrial membrane organization GO:0007006 26 0.200
Mouse
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 7 0.200
negative regulation of wnt signaling pathway GO:0030178 73 0.198
striated muscle cell proliferation GO:0014855 39 0.196
transmembrane transport GO:0055085 412 0.194
regulation of apoptotic signaling pathway GO:2001233 197 0.193
blood vessel remodeling GO:0001974 33 0.192
regulation of chromosome organization GO:0033044 83 0.191
Mouse
mesenchymal cell differentiation GO:0048762 107 0.191
cell differentiation involved in kidney development GO:0061005 33 0.191
neural crest cell migration GO:0001755 32 0.190

Trp63 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.485
bone disease DOID:0080001 0 0.485
disease of anatomical entity DOID:7 0 0.485
dysostosis DOID:1934 0 0.485
musculoskeletal system disease DOID:17 0 0.485
connective tissue disease DOID:65 0 0.485
cancer DOID:162 0 0.355
disease of cellular proliferation DOID:14566 0 0.355
organ system cancer DOID:0050686 0 0.355