Mus musculus

250 known processes

Trp73

transformation related protein 73

(Aliases: p73,Tp73)

Trp73 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to gamma radiation GO:0071480 4 0.996
Fly
negative regulation of dna replication GO:0008156 4 0.898
Mouse
urinary bladder development GO:0060157 5 0.889
Mouse
microtubule cytoskeleton organization GO:0000226 157 0.820
regulation of cellular catabolic process GO:0031329 242 0.809
Mouse Fly
dna metabolic process GO:0006259 303 0.795
Mouse Fly
cell fate commitment GO:0045165 210 0.742
Mouse
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.740
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.738
positive regulation of cellular catabolic process GO:0031331 148 0.718
Fly
leukocyte proliferation GO:0070661 172 0.701
Mouse
regulation of protein kinase activity GO:0045859 232 0.687
cerebrospinal fluid secretion GO:0033326 4 0.654
leukocyte differentiation GO:0002521 342 0.637
Mouse
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.618
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.617
female genitalia morphogenesis GO:0048807 3 0.587
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 73 0.575
Mouse
cellular response to dna damage stimulus GO:0006974 207 0.572
gland development GO:0048732 330 0.568
Mouse
positive regulation of programmed cell death GO:0043068 218 0.565
signal transduction involved in dna damage checkpoint GO:0072422 3 0.559
Mouse
divalent metal ion transport GO:0070838 172 0.546
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.546
response to hypoxia GO:0001666 58 0.536
Worm
cellular response to radiation GO:0071478 28 0.535
Mouse Fly
positive regulation of cell death GO:0010942 224 0.531
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.531
positive regulation of thymocyte apoptotic process GO:0070245 5 0.528
Mouse
positive regulation of endopeptidase activity GO:0010950 43 0.518
Fly
limb development GO:0060173 166 0.515
Mouse
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 8 0.508
Fly
protein processing GO:0016485 163 0.494
Mouse Fly
stem cell maintenance GO:0019827 130 0.492
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.479
Mouse
protein modification by small protein conjugation GO:0032446 187 0.477
microtubule based process GO:0007017 236 0.476
regulation of multi organism process GO:0043900 111 0.475
regulation of body fluid levels GO:0050878 162 0.472
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.472
forebrain development GO:0030900 302 0.471
axonogenesis GO:0007409 274 0.465
cellular amine metabolic process GO:0044106 44 0.464
regulation of peptidase activity GO:0052547 96 0.463
Mouse Fly
mitochondrial dna repair GO:0043504 3 0.461
Mouse
signal transduction by p53 class mediator GO:0072331 51 0.455
negative regulation of cellular catabolic process GO:0031330 47 0.453
Mouse
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.452
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.451
negative regulation of protein maturation GO:1903318 79 0.448
Mouse
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.443
Mouse
negative regulation of macroautophagy GO:0016242 5 0.442
Mouse
lymphocyte apoptotic process GO:0070227 54 0.436
Mouse
t cell proliferation involved in immune response GO:0002309 4 0.435
Mouse
positive regulation of leukocyte apoptotic process GO:2000108 21 0.424
Mouse
cell aging GO:0007569 35 0.423
Mouse
negative regulation of cellular protein catabolic process GO:1903363 22 0.423
transmembrane transport GO:0055085 412 0.415
b cell differentiation GO:0030183 78 0.412
Mouse
positive regulation of peptidase activity GO:0010952 49 0.397
Fly
apoptotic signaling pathway GO:0097190 306 0.394
response to radiation GO:0009314 165 0.392
Mouse Fly
positive regulation of hydrolase activity GO:0051345 148 0.385
Fly
t cell differentiation GO:0030217 174 0.381
Mouse
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.381
Mouse
positive regulation of proteolysis GO:0045862 85 0.372
Fly
positive regulation of interleukin 8 secretion GO:2000484 1 0.366
morphogenesis of a polarized epithelium GO:0001738 37 0.364
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.362
thymocyte apoptotic process GO:0070242 19 0.362
Mouse
dendrite development GO:0016358 115 0.360
regulation of chromosome organization GO:0033044 83 0.354
Mouse
regulation of endopeptidase activity GO:0052548 89 0.352
Mouse Fly
anion transport GO:0006820 177 0.349
regulation of hydrolase activity GO:0051336 246 0.346
Mouse Fly
regulation of protein localization GO:0032880 231 0.344
Fly
negative regulation of growth GO:0045926 99 0.341
Human
cell cycle arrest GO:0007050 37 0.339
rrna transcription GO:0009303 9 0.339
Mouse
regulation of stress activated mapk cascade GO:0032872 69 0.331
response to ionizing radiation GO:0010212 42 0.327
Mouse Fly
hippocampus development GO:0021766 52 0.322
stem cell differentiation GO:0048863 268 0.319
Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.313
lymphocyte proliferation GO:0046651 164 0.312
Mouse
protein maturation GO:0051604 176 0.310
Mouse Fly
regulation of epidermal cell division GO:0010482 3 0.309
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.308
embryonic organ morphogenesis GO:0048562 276 0.307
Zebrafish
positive regulation of cell cycle phase transition GO:1901989 17 0.306
gliogenesis GO:0042063 141 0.306
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.305
meiotic cell cycle GO:0051321 122 0.303
Worm Fly
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.295
Mouse
sensory perception GO:0007600 245 0.295
positive regulation of apoptotic process GO:0043065 217 0.294
oxygen homeostasis GO:0032364 2 0.291
negative regulation of leukocyte differentiation GO:1902106 51 0.291
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.290
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.289
negative regulation of fat cell differentiation GO:0045599 36 0.288
axis elongation involved in somitogenesis GO:0090245 4 0.287
ubiquitin dependent protein catabolic process GO:0006511 129 0.286
photoreceptor cell differentiation GO:0046530 52 0.284
Fly
peptide metabolic process GO:0006518 46 0.282
cell cycle checkpoint GO:0000075 47 0.281
Mouse
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.278
glial cell differentiation GO:0010001 131 0.274
peptidyl tyrosine modification GO:0018212 145 0.274
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.272
Mouse Fly
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.272
Fly
mitochondrion degradation GO:0000422 3 0.268
Mouse
response to oxygen levels GO:0070482 62 0.264
Worm
nuclear division GO:0000280 158 0.260
Worm Fly
negative regulation of phosphorus metabolic process GO:0010563 184 0.258
glial cell apoptotic process GO:0034349 3 0.257
positive regulation of cellular amine metabolic process GO:0033240 5 0.256
regulation of kinase activity GO:0043549 249 0.256
regulation of asymmetric cell division GO:0009786 4 0.255
t cell differentiation in thymus GO:0033077 77 0.254
Mouse
protein ubiquitination GO:0016567 171 0.254
negative regulation of kinase activity GO:0033673 81 0.249
stem cell development GO:0048864 219 0.248
regulation of protein processing GO:0070613 96 0.246
Mouse
pallium development GO:0021543 120 0.243
regulation of stem cell proliferation GO:0072091 78 0.235
Mouse
metencephalon development GO:0022037 89 0.232
Mouse
regionalization GO:0003002 337 0.231
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.229
maintenance of cell number GO:0098727 3 0.228
midgut development GO:0007494 4 0.227
hindbrain development GO:0030902 128 0.226
Mouse
regulation of protein maturation GO:1903317 96 0.226
Mouse
negative regulation of keratinocyte differentiation GO:0045617 4 0.224
Mouse
regulation of transferase activity GO:0051338 263 0.221
small gtpase mediated signal transduction GO:0007264 97 0.221
kidney development GO:0001822 213 0.221
regulation of neuron differentiation GO:0045664 281 0.220
Fly
ion transmembrane transport GO:0034220 361 0.220
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.219
Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.218
negative regulation of jun kinase activity GO:0043508 9 0.218
multicellular organism growth GO:0035264 161 0.217
Mouse Fly
cell fate specification GO:0001708 72 0.217
proteasomal protein catabolic process GO:0010498 98 0.217
embryonic skeletal system morphogenesis GO:0048704 91 0.217
Zebrafish
skeletal system morphogenesis GO:0048705 203 0.216
Zebrafish
regulation of cellular amino acid metabolic process GO:0006521 5 0.216
regulation of binding GO:0051098 111 0.213
segmentation GO:0035282 93 0.213
Mouse
regulation of proteolysis GO:0030162 164 0.212
Mouse Fly
divalent inorganic cation transport GO:0072511 178 0.212
regulation of cell cell adhesion mediated by cadherin GO:2000047 2 0.210
cellular ketone metabolic process GO:0042180 84 0.209
lung induction GO:0060492 3 0.208
cellular macromolecule catabolic process GO:0044265 206 0.206
inner medullary collecting duct development GO:0072061 2 0.204
modification dependent protein catabolic process GO:0019941 133 0.204
reciprocal dna recombination GO:0035825 16 0.204
Fly
regulation of leukocyte proliferation GO:0070663 121 0.200
t cell apoptotic process GO:0070231 39 0.199
Mouse
response to oxidative stress GO:0006979 123 0.198
Mouse Worm
meiotic nuclear division GO:0007126 115 0.198
Worm Fly
multicellular organismal homeostasis GO:0048871 164 0.195
regulation of cytoplasmic transport GO:1903649 112 0.195
Fly
central nervous system neuron development GO:0021954 67 0.194
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.193
positive regulation of myeloid cell differentiation GO:0045639 43 0.192
intrinsic apoptotic signaling pathway GO:0097193 132 0.191
salivary gland development GO:0007431 37 0.191
mesonephric duct formation GO:0072181 2 0.188
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.188
appendage development GO:0048736 166 0.188
Mouse
regulation of organ growth GO:0046620 61 0.187
Human Fly
cellular response to acid chemical GO:0071229 68 0.186
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 6 0.186
chromatin organization GO:0006325 206 0.185
Mouse
regulation of interleukin 8 secretion GO:2000482 2 0.185
positive regulation of antimicrobial peptide production GO:0002225 1 0.185
negative regulation of lipid kinase activity GO:0090219 1 0.183
Fly
protein catabolic process GO:0030163 221 0.182
appendage morphogenesis GO:0035107 149 0.180
Mouse
regulation of leukocyte apoptotic process GO:2000106 56 0.178
Mouse
multicellular organismal response to stress GO:0033555 62 0.176
renal outer medulla development GO:0072054 2 0.176
regulation of mapk cascade GO:0043408 248 0.173
regulation of lymphocyte activation GO:0051249 240 0.173
gas homeostasis GO:0033483 3 0.172
hindbrain morphogenesis GO:0021575 46 0.172
negative regulation of proteolysis GO:0045861 74 0.171
Mouse
cellular response to starvation GO:0009267 57 0.170
Mouse Fly
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 0.170
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.169
Mouse
positive regulation of cell aging GO:0090343 1 0.168
Mouse
neuron death GO:0070997 154 0.168
regulation of protein targeting GO:1903533 61 0.167
Fly
stem cell proliferation GO:0072089 117 0.166
Mouse Fly
regulation of cell activation GO:0050865 289 0.166
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.166
protein localization to membrane GO:0072657 108 0.165
foregut regionalization GO:0060423 3 0.165
negative regulation of protein modification process GO:0031400 163 0.164
regulation of chromatin modification GO:1903308 57 0.164
Mouse
heart morphogenesis GO:0003007 178 0.163
regulation of protein import into nucleus GO:0042306 52 0.163
Fly
establishment of tissue polarity GO:0007164 28 0.163
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.162
regulation of cell cycle GO:0051726 281 0.162
regulation of epidermal cell differentiation GO:0045604 21 0.162
Mouse
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.160
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.160
cerebellum development GO:0021549 77 0.159
Mouse
neurotransmitter secretion GO:0007269 62 0.158
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.157
regulation of testosterone biosynthetic process GO:2000224 2 0.156
cellular protein catabolic process GO:0044257 155 0.155
cell growth GO:0016049 130 0.155
leukocyte apoptotic process GO:0071887 71 0.155
Mouse
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.154
positive regulation of cell development GO:0010720 237 0.154
regulation of receptor activity GO:0010469 41 0.154
bmp signaling pathway GO:0030509 93 0.153
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.153
lymphocyte differentiation GO:0030098 242 0.152
Mouse
regulation of response to dna damage stimulus GO:2001020 34 0.152
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.151
Mouse
histone modification GO:0016570 159 0.150
Mouse
renal system development GO:0072001 225 0.149
Mouse
nucleocytoplasmic transport GO:0006913 139 0.149
Mouse Fly
renal vesicle induction GO:0072034 3 0.149
regulation of cytokine production GO:0001817 266 0.149
embryonic limb morphogenesis GO:0030326 126 0.149
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.149
negative regulation of molecular function GO:0044092 258 0.148
negative regulation of fibroblast proliferation GO:0048147 14 0.148
Mouse
dna replication GO:0006260 52 0.147
Mouse
activation of cysteine type endopeptidase activity GO:0097202 27 0.147
Fly
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.147
somite development GO:0061053 81 0.146
Mouse
regulation of neuron apoptotic process GO:0043523 122 0.145
detection of external stimulus GO:0009581 61 0.145
autophagy GO:0006914 45 0.145
Mouse Fly
regulation of axon extension GO:0030516 43 0.144
ras protein signal transduction GO:0007265 77 0.144
regulation of anagen GO:0051884 1 0.144
cellular response to x ray GO:0071481 2 0.143
Fly
inflammatory response GO:0006954 244 0.143
negative regulation of phosphorylation GO:0042326 166 0.143
reactive oxygen species metabolic process GO:0072593 84 0.142
Mouse
regulation of lipid metabolic process GO:0019216 118 0.141
Fly
positive regulation of mesoderm development GO:2000382 2 0.141
regulation of proteasomal protein catabolic process GO:0061136 46 0.139
positive regulation of cell motility GO:2000147 116 0.137
establishment of organ orientation GO:0048561 1 0.137
positive regulation of actin filament bundle assembly GO:0032233 11 0.136
palate development GO:0060021 76 0.135
lateral inhibition GO:0046331 1 0.134
positive regulation of neuron projection development GO:0010976 79 0.134
somatic stem cell maintenance GO:0035019 47 0.133
digestive tract development GO:0048565 190 0.132
positive regulation of protein modification process GO:0031401 299 0.132
Mouse
positive regulation of mapk cascade GO:0043410 170 0.132
regulation of map kinase activity GO:0043405 120 0.132
mapk cascade GO:0000165 281 0.132
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.131
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.131
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.131
Mouse
response to organonitrogen compound GO:0010243 246 0.131
cellular amide metabolic process GO:0043603 58 0.131
cellular amino acid metabolic process GO:0006520 103 0.131
b cell activation GO:0042113 161 0.129
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.129
Human Mouse
cellular response to parathyroid hormone stimulus GO:0071374 2 0.129
camera type eye development GO:0043010 266 0.128
regulation of leukocyte differentiation GO:1902105 159 0.127
regulation of b cell activation GO:0050864 81 0.127
multi multicellular organism process GO:0044706 109 0.127
positive regulation of macroautophagy GO:0016239 3 0.126
Fly
regulation of fibroblast growth factor production GO:0090270 4 0.126
negative regulation of epidermal cell differentiation GO:0045605 7 0.125
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.125
mitotic cell cycle GO:0000278 195 0.125
Human Mouse
negative regulation of cellular senescence GO:2000773 3 0.125
water homeostasis GO:0030104 27 0.124
Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.124
Mouse
cellular senescence GO:0090398 11 0.123
antimicrobial peptide biosynthetic process GO:0002777 2 0.123
amine metabolic process GO:0009308 45 0.123
regulation of cell projection organization GO:0031344 206 0.123
positive regulation of neuron apoptotic process GO:0043525 25 0.123
Mouse
ribonucleoside catabolic process GO:0042454 206 0.122
organelle fission GO:0048285 170 0.121
Worm Fly
multicellular organismal water homeostasis GO:0050891 23 0.120
Mouse
mammary gland epithelium development GO:0061180 65 0.119
carboxylic acid transport GO:0046942 100 0.119
jnk cascade GO:0007254 72 0.118
positive regulation of leukocyte differentiation GO:1902107 86 0.118
myeloid cell homeostasis GO:0002262 114 0.118
regulation of synaptic plasticity GO:0048167 87 0.118
cellular response to ionizing radiation GO:0071479 11 0.117
Mouse Fly
nucleoside triphosphate metabolic process GO:0009141 230 0.116
regulation of neuron projection development GO:0010975 169 0.116
defense response to other organism GO:0098542 197 0.115
regulation of antimicrobial humoral response GO:0002759 3 0.115
ameboidal type cell migration GO:0001667 128 0.115
regulation of protein serine threonine kinase activity GO:0071900 157 0.115
neuron projection extension GO:1990138 64 0.114
cellular response to growth factor stimulus GO:0071363 197 0.114
Mouse
neuroblast differentiation GO:0014016 2 0.114
Fly
spermatogenesis GO:0007283 284 0.114
midbrain hindbrain boundary maturation GO:0021732 1 0.113
response to extracellular stimulus GO:0009991 127 0.112
Mouse Worm Fly
regulation of microtubule based process GO:0032886 52 0.111
organic cyclic compound catabolic process GO:1901361 295 0.111
synaptic transmission GO:0007268 329 0.111
epithelial cell proliferation GO:0050673 174 0.111
Mouse
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.111
nuclear transport GO:0051169 139 0.110
Mouse Fly
positive regulation of nervous system development GO:0051962 221 0.110
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.110
Mouse
cellular ion homeostasis GO:0006873 165 0.110
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.109
Mouse
interleukin 8 production GO:0032637 4 0.109
homeostasis of number of cells GO:0048872 210 0.109
regulation of cellular response to growth factor stimulus GO:0090287 82 0.108
Mouse
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.108
skin development GO:0043588 220 0.107
Mouse
negative regulation of protein processing GO:0010955 79 0.107
Mouse
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.107
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.106
Mouse
formation of radial glial scaffolds GO:0021943 4 0.105
chromatin modification GO:0016568 187 0.105
Mouse
regulation of thymocyte apoptotic process GO:0070243 14 0.105
Mouse
regulation of epidermis development GO:0045682 33 0.105
Mouse
wnt signaling pathway GO:0016055 188 0.105
immune response activating signal transduction GO:0002757 116 0.104
mitotic g1 dna damage checkpoint GO:0031571 4 0.104
Mouse
peptidyl tyrosine phosphorylation GO:0018108 143 0.104
Mouse
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.104
regulation of reactive oxygen species metabolic process GO:2000377 40 0.103
Mouse
regulation of b cell proliferation GO:0030888 39 0.102
negative regulation of transferase activity GO:0051348 85 0.102
central nervous system morphogenesis GO:0021551 2 0.102
negative regulation of bmp signaling pathway GO:0030514 35 0.102
outer medullary collecting duct development GO:0072060 1 0.101
cellular response to external stimulus GO:0071496 88 0.101
Mouse Fly
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.101
Fly
regulation of protein catabolic process GO:0042176 108 0.101
response to pain GO:0048265 26 0.100
morphogenesis of embryonic epithelium GO:0016331 159 0.100
Mouse
fertilization GO:0009566 127 0.100
hypophysis morphogenesis GO:0048850 3 0.100
negative regulation of cell proliferation GO:0008285 296 0.100
Human Mouse
muscle fiber development GO:0048747 76 0.100
organic acid transport GO:0015849 101 0.099
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.099
Mouse
cell division GO:0051301 120 0.099
Mouse
methylation GO:0032259 134 0.099
regulation of cell cycle process GO:0010564 160 0.099
Mouse
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.099
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000081 1 0.098
mitochondrial membrane organization GO:0007006 26 0.097
Mouse
mitotic nuclear division GO:0007067 48 0.097
positive regulation of transforming growth factor beta2 production GO:0032915 2 0.096
b cell proliferation GO:0042100 53 0.095
positive regulation of organelle organization GO:0010638 128 0.095
Mouse
regulation of cell growth GO:0001558 91 0.094
regulation of protein transport GO:0051223 163 0.094
Fly
neuroblast proliferation GO:0007405 49 0.094
Mouse Fly
fibroblast proliferation GO:0048144 35 0.093
Mouse
regulation of cardioblast differentiation GO:0051890 3 0.093
positive regulation of protein phosphorylation GO:0001934 242 0.093
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.093
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.093
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.092
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.092
cytokine production GO:0001816 319 0.091
response to drug GO:0042493 75 0.091
Mouse
regulation of reproductive process GO:2000241 66 0.091
fibroblast growth factor production GO:0090269 4 0.091
single fertilization GO:0007338 82 0.090
regulation of ras protein signal transduction GO:0046578 114 0.089
regulation of jnk cascade GO:0046328 62 0.089
inorganic ion transmembrane transport GO:0098660 234 0.089
necrotic cell death GO:0070265 30 0.088
Mouse
positive regulation of transferase activity GO:0051347 167 0.088
dna damage checkpoint GO:0000077 26 0.088
Mouse
negative regulation of cell cycle GO:0045786 123 0.087
androgen biosynthetic process GO:0006702 4 0.086
positive regulation of cell cycle GO:0045787 92 0.086
Mouse Fly
oxidation reduction process GO:0055114 342 0.085
male gamete generation GO:0048232 285 0.085
sensory organ morphogenesis GO:0090596 242 0.085
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.085
morphogenesis of an epithelial sheet GO:0002011 27 0.085
regulation of protein tyrosine kinase activity GO:0061097 17 0.085
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.084
myeloid cell differentiation GO:0030099 233 0.084
negative regulation of stem cell proliferation GO:2000647 12 0.084
Mouse
skeletal muscle organ development GO:0060538 163 0.084
organic anion transport GO:0015711 137 0.084
regulation of lymphocyte proliferation GO:0050670 117 0.084
nephron epithelium development GO:0072009 92 0.084
positive regulation of protein kinase activity GO:0045860 144 0.084
cytoplasmic transport GO:0016482 234 0.084
Mouse Fly
developmental cell growth GO:0048588 84 0.084
macromolecule catabolic process GO:0009057 281 0.083
establishment of endothelial blood brain barrier GO:0014045 3 0.083
epithelial tube formation GO:0072175 130 0.083
neural precursor cell proliferation GO:0061351 121 0.083
Mouse Fly
mitotic cell cycle checkpoint GO:0007093 31 0.083
Mouse
positive regulation of t cell apoptotic process GO:0070234 8 0.083
Mouse
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.082
cardiac right atrium morphogenesis GO:0003213 3 0.082
g1 s transition of mitotic cell cycle GO:0000082 57 0.082
Mouse
testosterone biosynthetic process GO:0061370 2 0.082
somitogenesis GO:0001756 69 0.082
Mouse
negative regulation of endopeptidase activity GO:0010951 44 0.082
peptidyl amino acid modification GO:0018193 336 0.081
Mouse
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.081
lung field specification GO:0060424 3 0.081
muscle cell differentiation GO:0042692 261 0.080
spemann organizer formation GO:0060061 2 0.080
regulation of cell division GO:0051302 76 0.080
Mouse
response to gamma radiation GO:0010332 22 0.080
Mouse Fly
placenta development GO:0001890 140 0.079
macroautophagy GO:0016236 21 0.079
Mouse Fly
cervix development GO:0060067 2 0.079
gtp catabolic process GO:0006184 143 0.079
ossification GO:0001503 216 0.079
organ growth GO:0035265 117 0.078
Human Fly
regulation of protein deacetylation GO:0090311 17 0.078
Mouse
cardiac cell fate specification GO:0060912 2 0.078
regulation of cardiac cell fate specification GO:2000043 1 0.078
t cell activation GO:0042110 289 0.078
Mouse
establishment or maintenance of cell polarity GO:0007163 86 0.077
digestive system development GO:0055123 200 0.077
neuronal stem cell division GO:0036445 10 0.077
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.077
t cell proliferation GO:0042098 120 0.077
Mouse
membrane organization GO:0061024 245 0.076
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.076
positive regulation of anagen GO:0051885 1 0.076
protein localization to organelle GO:0033365 185 0.076
Mouse Fly
negative regulation of neuron death GO:1901215 98 0.075
motor neuron migration GO:0097475 4 0.075
regulation of gliogenesis GO:0014013 50 0.075
uterus morphogenesis GO:0061038 2 0.075
negative regulation of neuron differentiation GO:0045665 101 0.075
Fly
negative regulation of mapk cascade GO:0043409 65 0.075
positive regulation of cell cell adhesion mediated by cadherin GO:2000049 2 0.075
organonitrogen compound catabolic process GO:1901565 264 0.074
calcium ion transmembrane transport GO:0070588 85 0.074
purine nucleoside catabolic process GO:0006152 205 0.074
cellular response to nutrient levels GO:0031669 64 0.074
Mouse Fly
glycosyl compound catabolic process GO:1901658 206 0.074
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.074
positive regulation of jnk cascade GO:0046330 46 0.073
purine ribonucleotide metabolic process GO:0009150 290 0.073
keratinocyte differentiation GO:0030216 48 0.073
Mouse
cerebellar cortex development GO:0021695 48 0.073
metanephros development GO:0001656 79 0.073
purine containing compound metabolic process GO:0072521 311 0.072
cellular response to lipid GO:0071396 145 0.072
ribonucleotide metabolic process GO:0009259 291 0.072
positive regulation of cell cycle process GO:0090068 61 0.072
Mouse
central nervous system neuron differentiation GO:0021953 162 0.072
response to organic cyclic compound GO:0014070 198 0.072
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.072
positive regulation of rho gtpase activity GO:0032321 41 0.072
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 14 0.072
Mouse
positive regulation of nucleoside metabolic process GO:0045979 91 0.072
developmental growth involved in morphogenesis GO:0060560 138 0.071
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.070
Fly
positive regulation of osteoblast differentiation GO:0045669 34 0.070
cation homeostasis GO:0055080 212 0.070
urogenital system development GO:0001655 261 0.070
Mouse
response to acid chemical GO:0001101 111 0.070
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.070
cation transmembrane transport GO:0098655 266 0.069
response to starvation GO:0042594 65 0.069
Mouse Worm Fly
positive regulation of nucleotide metabolic process GO:0045981 114 0.069
negative regulation of map kinase activity GO:0043407 34 0.069
cerebellar cortex morphogenesis GO:0021696 32 0.069
mitotic cell cycle process GO:1903047 159 0.068
Mouse
positive regulation of cell migration GO:0030335 109 0.068
regulation of transforming growth factor beta2 production GO:0032909 2 0.068
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.068
response to uv GO:0009411 44 0.068
Mouse Fly
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.068
Fly

Trp73 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.353
cancer DOID:162 0 0.229
organ system cancer DOID:0050686 0 0.142
disease of anatomical entity DOID:7 0 0.133
integumentary system disease DOID:16 0 0.133