|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.914
|
Fly |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.862
|
Human Fly |
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.858
|
|
|
|
negative regulation of insulin receptor signaling pathway
|
GO:0046627 |
14 |
0.845
|
Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.813
|
|
|
|
negative regulation of organ growth
|
GO:0046621 |
17 |
0.779
|
Fly |
|
|
protein transport into membrane raft
|
GO:0032596 |
4 |
0.764
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.709
|
|
|
|
pole plasm assembly
|
GO:0007315 |
2 |
0.709
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
78 |
0.698
|
Fly |
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.680
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.676
|
|
|
|
negative regulation of cell size
|
GO:0045792 |
3 |
0.673
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.664
|
|
|
|
regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0000083 |
3 |
0.655
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.638
|
Human |
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.635
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.633
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.633
|
|
|
|
regulation of autophagy
|
GO:0010506 |
30 |
0.633
|
Fly |
|
|
negative regulation of tor signaling
|
GO:0032007 |
13 |
0.632
|
Human Fly |
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.631
|
Human Fly |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.590
|
Human Fly |
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.588
|
Human Fly |
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.571
|
Human Fly |
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.565
|
|
|
|
autophagy
|
GO:0006914 |
45 |
0.565
|
Fly |
|
|
oocyte axis specification
|
GO:0007309 |
2 |
0.563
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.556
|
Human Fly |
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.552
|
Fly |
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.548
|
Human Fly |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.538
|
Human Fly |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.537
|
Human Fly |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.534
|
Human Fly |
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.533
|
Human Fly |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.523
|
Human Fly |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.508
|
Human Fly |
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.507
|
Fly |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.506
|
Human Fly |
|
|
positive regulation of autophagy
|
GO:0010508 |
9 |
0.505
|
Fly |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.501
|
Human Fly |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.494
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.479
|
Human Fly |
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.478
|
Fly |
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.473
|
Fly |
|
|
carbohydrate transport
|
GO:0008643 |
62 |
0.467
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.466
|
Human Fly |
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.463
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.463
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.456
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.453
|
Human Fly |
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.453
|
Fly |
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.441
|
Human |
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.441
|
Human Fly |
|
|
regulation of cell size
|
GO:0008361 |
72 |
0.436
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.436
|
Human Fly |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.428
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.427
|
Fly |
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.423
|
Human Fly |
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.420
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.418
|
Human Fly |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.418
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.408
|
Human Fly |
|
|
neural tube closure
|
GO:0001843 |
90 |
0.407
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.397
|
Human Fly |
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.396
|
Fly |
|
|
pallium development
|
GO:0021543 |
120 |
0.395
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.393
|
Fly |
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.392
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.389
|
Human Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.387
|
Human Fly |
|
|
synapse organization
|
GO:0050808 |
125 |
0.386
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.383
|
Human Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.382
|
Human Fly |
|
|
mapk cascade
|
GO:0000165 |
281 |
0.379
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.376
|
Human Fly |
|
|
synaptic growth at neuromuscular junction
|
GO:0051124 |
6 |
0.371
|
|
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.368
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.367
|
Human Fly |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.365
|
Fly |
|
|
negative regulation of synapse assembly
|
GO:0051964 |
3 |
0.364
|
|
|
|
limbic system development
|
GO:0021761 |
72 |
0.349
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.349
|
Human Fly |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.348
|
Human Fly |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.342
|
Human Fly |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.338
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.332
|
Human Fly |
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.330
|
Human Fly |
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.324
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.315
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.310
|
Human Fly |
|
|
glucose import
|
GO:0046323 |
32 |
0.309
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.309
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.307
|
Human Fly |
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.305
|
Human Fly |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.302
|
|
|
|
negative regulation of glial cell proliferation
|
GO:0060253 |
4 |
0.301
|
|
|
|
endomembrane system organization
|
GO:0010256 |
147 |
0.300
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
17 |
0.297
|
Human Zebrafish Fly |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.292
|
Human Fly |
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.290
|
Human Fly |
|
|
developmental maturation
|
GO:0021700 |
193 |
0.284
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.280
|
Fly |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.277
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.277
|
|
|
|
plasma membrane organization
|
GO:0007009 |
90 |
0.275
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.274
|
|
|
|
glucose transport
|
GO:0015758 |
56 |
0.268
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.263
|
Human Fly |
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.263
|
|
|
|
oocyte anterior posterior axis specification
|
GO:0007314 |
2 |
0.263
|
|
|
|
regulation of cell growth
|
GO:0001558 |
91 |
0.263
|
Fly |
|
|
chromosome separation
|
GO:0051304 |
14 |
0.263
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.258
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
64 |
0.258
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.257
|
Human Fly |
|
|
oocyte construction
|
GO:0007308 |
2 |
0.257
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.255
|
Human Fly |
|
|
spermatid development
|
GO:0007286 |
108 |
0.253
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.250
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.249
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.248
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.247
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.246
|
|
|
|
regulation of hippo signaling
|
GO:0035330 |
1 |
0.243
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.242
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.242
|
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.241
|
Fly |
|
|
oocyte differentiation
|
GO:0009994 |
35 |
0.239
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.238
|
Human Fly |
|
|
organ growth
|
GO:0035265 |
117 |
0.236
|
Fly |
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.236
|
|
|
|
oogenesis
|
GO:0048477 |
56 |
0.234
|
Fly |
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.234
|
Fly |
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.230
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.230
|
Human Fly |
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.228
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.224
|
|
|
|
tor signaling
|
GO:0031929 |
21 |
0.223
|
Human Zebrafish Fly |
|
|
organelle fission
|
GO:0048285 |
170 |
0.222
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.221
|
Human Fly |
|
|
response to radiation
|
GO:0009314 |
165 |
0.221
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.217
|
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.216
|
Fly |
|
|
cell growth
|
GO:0016049 |
130 |
0.211
|
Fly |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.211
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
44 |
0.210
|
Fly |
|
|
male gamete generation
|
GO:0048232 |
285 |
0.210
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.209
|
Human |
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.199
|
Human Fly |
|
|
acute inflammatory response
|
GO:0002526 |
41 |
0.198
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.197
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.191
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.189
|
|
|
|
negative regulation of dna replication
|
GO:0008156 |
4 |
0.188
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.186
|
Human Fly |
|
|
response to decreased oxygen levels
|
GO:0036293 |
59 |
0.186
|
Fly |
|
|
neural tube formation
|
GO:0001841 |
108 |
0.184
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.181
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.179
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.177
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.176
|
Human |
|
|
regulation of protein stability
|
GO:0031647 |
52 |
0.174
|
Human |
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.172
|
Human Fly |
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.171
|
Human Fly |
|
|
protein localization to plasma membrane
|
GO:0072659 |
57 |
0.170
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.169
|
|
|
|
tube closure
|
GO:0060606 |
91 |
0.169
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.166
|
Human |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.165
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.163
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.160
|
Human Fly |
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.158
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.157
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.156
|
Human Fly |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.154
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
73 |
0.150
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.149
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.148
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
115 |
0.148
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.147
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.144
|
Human Fly |
|
|
protein localization to membrane raft
|
GO:1903044 |
4 |
0.143
|
|
|
|
negative regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042524 |
2 |
0.143
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.143
|
Human Fly |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.142
|
|
|
|
sperm individualization
|
GO:0007291 |
1 |
0.141
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.140
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.140
|
|
|
|
cellularization
|
GO:0007349 |
1 |
0.139
|
|
|
|
response to nutrient
|
GO:0007584 |
12 |
0.139
|
Fly |
|
|
dna damage checkpoint
|
GO:0000077 |
26 |
0.139
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
11 |
0.137
|
Fly |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.137
|
Human |
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.137
|
|
|
|
cell maturation
|
GO:0048469 |
127 |
0.135
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.135
|
Human Fly |
|
|
phagocytosis
|
GO:0006909 |
66 |
0.133
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
56 |
0.132
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.131
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.131
|
Human Fly |
|
|
protein import
|
GO:0017038 |
101 |
0.130
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.128
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.127
|
|
|
|
hippo signaling
|
GO:0035329 |
11 |
0.125
|
|
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.124
|
|
|
|
cell cell signaling involved in cell fate commitment
|
GO:0045168 |
35 |
0.117
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.117
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.116
|
|
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
51 |
0.115
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
9 |
0.115
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
18 |
0.115
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.115
|
|
|
|
protein localization to membrane
|
GO:0072657 |
108 |
0.113
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.112
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.108
|
|
|
|
regulation of microtubule polymerization
|
GO:0031113 |
7 |
0.106
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.106
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
24 |
0.105
|
Fly |
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.105
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.104
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.104
|
|
|
|
chromosome segregation
|
GO:0007059 |
48 |
0.102
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.102
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.100
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
57 |
0.099
|
|
|
|
tube formation
|
GO:0035148 |
140 |
0.098
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.098
|
Human Fly |
|
|
rna localization
|
GO:0006403 |
23 |
0.097
|
Human |
|
|
synapse assembly
|
GO:0007416 |
56 |
0.095
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.093
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.093
|
Human |
|
|
skeletal system development
|
GO:0001501 |
356 |
0.093
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
40 |
0.092
|
Human |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.090
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.090
|
|
|
|
negative regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045736 |
9 |
0.090
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
16 |
0.089
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.089
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.089
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.087
|
|
|
|
odontogenesis of dentin containing tooth
|
GO:0042475 |
66 |
0.087
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.085
|
|
|
|
intra s dna damage checkpoint
|
GO:0031573 |
4 |
0.083
|
|
|
|
protein transport within lipid bilayer
|
GO:0032594 |
5 |
0.082
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
62 |
0.082
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.082
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
17 |
0.081
|
Fly |
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
49 |
0.081
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
41 |
0.081
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.080
|
|
|
|
schwann cell proliferation
|
GO:0014010 |
2 |
0.079
|
|
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
34 |
0.079
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
30 |
0.079
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.078
|
|
|
|
insulin like growth factor receptor signaling pathway
|
GO:0048009 |
21 |
0.078
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.078
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.078
|
Human |
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
1 |
0.078
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.078
|
|
|
|
macromolecule methylation
|
GO:0043414 |
120 |
0.078
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
70 |
0.077
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.077
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
58 |
0.076
|
|
|
|
oocyte development
|
GO:0048599 |
33 |
0.076
|
|
|
|
mesoderm development
|
GO:0007498 |
100 |
0.076
|
|
|
|
intracellular mrna localization
|
GO:0008298 |
4 |
0.075
|
|
|
|
methylation
|
GO:0032259 |
134 |
0.075
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.074
|
|
|
|
negative regulation of tyrosine phosphorylation of stat protein
|
GO:0042532 |
3 |
0.074
|
|
|
|
regulation of stress fiber assembly
|
GO:0051492 |
15 |
0.074
|
Human |
|
|
inositol lipid mediated signaling
|
GO:0048017 |
41 |
0.073
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.073
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.073
|
Human Fly |
|
|
positive regulation of macroautophagy
|
GO:0016239 |
3 |
0.071
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
36 |
0.071
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.071
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.070
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.070
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.070
|
|
|
|
positive regulation of microtubule polymerization
|
GO:0031116 |
3 |
0.069
|
|
|
|
maternal determination of anterior posterior axis embryo
|
GO:0008358 |
2 |
0.069
|
|
|
|
oxidation reduction process
|
GO:0055114 |
342 |
0.069
|
|
|
|
cell aging
|
GO:0007569 |
35 |
0.069
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.069
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.069
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.069
|
|
|
|
meiotic cytokinesis
|
GO:0033206 |
5 |
0.066
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.066
|
|
|
|
regulation of synapse assembly
|
GO:0051963 |
29 |
0.066
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.065
|
Human |
|
|
cell junction organization
|
GO:0034330 |
77 |
0.065
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.064
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
2 |
0.064
|
|
|
|
regulation of cellular response to insulin stimulus
|
GO:1900076 |
30 |
0.064
|
Fly |
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
3 |
0.063
|
|
|
|
mesoderm morphogenesis
|
GO:0048332 |
64 |
0.063
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.063
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.063
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.062
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.062
|
Human |
|
|
camera type eye development
|
GO:0043010 |
266 |
0.061
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.061
|
|
|
|
embryonic skeletal system development
|
GO:0048706 |
120 |
0.061
|
|
|
|
regulation of response to drug
|
GO:2001023 |
2 |
0.060
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.060
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.060
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.058
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.057
|
|
|
|
cytokinesis
|
GO:0000910 |
17 |
0.056
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.056
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.056
|
Human Fly |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.055
|
|
|
|
establishment or maintenance of microtubule cytoskeleton polarity
|
GO:0030951 |
1 |
0.054
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.054
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.054
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.054
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.053
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
169 |
0.053
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.053
|
|
|
|
negative regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0071930 |
1 |
0.052
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.052
|
|
|
|
cell cell junction organization
|
GO:0045216 |
72 |
0.052
|
Human |
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.052
|
Human |
|
|
cation transport
|
GO:0006812 |
399 |
0.052
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.052
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.051
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.051
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.050
|
|
|
|
generation of precursor metabolites and energy
|
GO:0006091 |
103 |
0.050
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.049
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.049
|
|
|
|
hippocampus development
|
GO:0021766 |
52 |
0.049
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
82 |
0.048
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.048
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.048
|
Human |
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.047
|
|
|
|
negative regulation of nuclear division
|
GO:0051784 |
19 |
0.047
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.047
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
69 |
0.047
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.047
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.046
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
122 |
0.046
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
18 |
0.046
|
Fly |
|
|
jak stat cascade
|
GO:0007259 |
42 |
0.045
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.045
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.045
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.045
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.044
|
|
|
|
negative regulation of cell division
|
GO:0051782 |
24 |
0.044
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
56 |
0.044
|
|
|
|
cellular response to starvation
|
GO:0009267 |
57 |
0.044
|
|
|
|
protein polymerization
|
GO:0051258 |
57 |
0.044
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
77 |
0.044
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.044
|
|
|
|
sensory perception of sound
|
GO:0007605 |
97 |
0.043
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.043
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.043
|
|
|
|
canonical wnt signaling pathway involved in negative regulation of apoptotic process
|
GO:0044336 |
4 |
0.043
|
|
|
|
organelle assembly
|
GO:0070925 |
177 |
0.042
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.042
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.042
|
|
|
|
lung development
|
GO:0030324 |
164 |
0.042
|
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
34 |
0.042
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
35 |
0.041
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
48 |
0.041
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
94 |
0.041
|
Human |
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.041
|
|
|
|
positive chemotaxis
|
GO:0050918 |
18 |
0.041
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.041
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.041
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.040
|
|
|
|
regulation of actin filament bundle assembly
|
GO:0032231 |
18 |
0.040
|
Human |
|
|
microtubule based process
|
GO:0007017 |
236 |
0.040
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.039
|
|
|
|
protein methylation
|
GO:0006479 |
81 |
0.039
|
|
|
|
somitogenesis
|
GO:0001756 |
69 |
0.039
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
86 |
0.039
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.039
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
28 |
0.038
|
|
|
|
ectoderm development
|
GO:0007398 |
15 |
0.038
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.038
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
86 |
0.038
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
88 |
0.038
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.038
|
|
|
|
nucleotide excision repair
|
GO:0006289 |
13 |
0.037
|
|
|
|
regulation of gliogenesis
|
GO:0014013 |
50 |
0.037
|
|
|
|
gene silencing
|
GO:0016458 |
38 |
0.037
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
90 |
0.037
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.037
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.037
|
|
|
|
histone lysine methylation
|
GO:0034968 |
50 |
0.037
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
91 |
0.037
|
|
|
|
muscle cell development
|
GO:0055001 |
133 |
0.037
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.036
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
79 |
0.036
|
|
|
|
dna modification
|
GO:0006304 |
50 |
0.036
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.036
|
|
|
|
apical protein localization
|
GO:0045176 |
7 |
0.036
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.036
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
42 |
0.036
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.036
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.036
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.036
|
|
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
3 |
0.036
|
|
|
|
mesenchyme development
|
GO:0060485 |
152 |
0.035
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.035
|
|
|
|
macroautophagy
|
GO:0016236 |
21 |
0.035
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.035
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.035
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.035
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.035
|
|
|
|
histone methylation
|
GO:0016571 |
71 |
0.035
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.034
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
21 |
0.034
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.034
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.034
|
|
|
|
regulation of dna replication
|
GO:0006275 |
17 |
0.034
|
|
|
|
negative regulation of mammary gland epithelial cell proliferation
|
GO:0033600 |
3 |
0.034
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.033
|
Human |
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.033
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.033
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.033
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
19 |
0.033
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.033
|
|
|
|
activation of adenylate cyclase activity
|
GO:0007190 |
4 |
0.033
|
|
|
|
cell cycle arrest
|
GO:0007050 |
37 |
0.033
|
|
|
|
energy derivation by oxidation of organic compounds
|
GO:0015980 |
77 |
0.033
|
|
|
|
fatty acid biosynthetic process
|
GO:0006633 |
41 |
0.032
|
|
|
|
negative regulation of ligase activity
|
GO:0051352 |
3 |
0.032
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.032
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
51 |
0.032
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
4 |
0.032
|
|
|
|
regulation of blood pressure
|
GO:0008217 |
93 |
0.032
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.032
|
|
|
|
positive regulation of smooth muscle cell migration
|
GO:0014911 |
4 |
0.032
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.032
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.032
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.031
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.031
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
9 |
0.031
|
|
|
|
cohesin localization to chromatin
|
GO:0071921 |
1 |
0.031
|
|
|
|
dna replication
|
GO:0006260 |
52 |
0.031
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.031
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.030
|
|
|
|
positive regulation of microtubule polymerization or depolymerization
|
GO:0031112 |
3 |
0.030
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
20 |
0.030
|
Fly |
|
|
somatic stem cell maintenance
|
GO:0035019 |
47 |
0.030
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.030
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.030
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.030
|
Human Fly |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
45 |
0.030
|
|
|
|
negative regulation of fibroblast migration
|
GO:0010764 |
2 |
0.030
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
191 |
0.030
|
|
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
41 |
0.030
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.030
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
3 |
0.030
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.030
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.029
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
43 |
0.029
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.029
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.029
|
|
|
|
regulation of macroautophagy
|
GO:0016241 |
12 |
0.029
|
|
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.029
|
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.029
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
59 |
0.029
|
|
|
|
negative regulation of lymphocyte differentiation
|
GO:0045620 |
32 |
0.029
|
|
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
3 |
0.029
|
|
|
|
negative regulation of rac protein signal transduction
|
GO:0035021 |
4 |
0.029
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.028
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.028
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
70 |
0.028
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
77 |
0.028
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
54 |
0.028
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.028
|
|
|
|
embryonic axis specification
|
GO:0000578 |
30 |
0.028
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.028
|
|
|
|
regulation of cohesin localization to chromatin
|
GO:0071922 |
1 |
0.028
|
|
|
|
positive regulation of protein export from nucleus
|
GO:0046827 |
4 |
0.028
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
31 |
0.027
|
|
|
|
heart morphogenesis
|
GO:0003007 |
178 |
0.027
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.027
|
|
