Mus musculus

265 known processes

Tsc2

tuberous sclerosis 2

(Aliases: Tcs2)

Tsc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of tor signaling GO:0032006 17 0.902
negative regulation of cell size GO:0045792 3 0.832
Rat Fly
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.819
Fly
neural tube closure GO:0001843 90 0.816
regulation of insulin receptor signaling pathway GO:0046626 21 0.786
forebrain development GO:0030900 302 0.754
embryonic epithelial tube formation GO:0001838 130 0.751
epithelial tube morphogenesis GO:0060562 303 0.732
hippocampus development GO:0021766 52 0.717
cilium morphogenesis GO:0060271 102 0.698
oocyte axis specification GO:0007309 2 0.685
telencephalon development GO:0021537 186 0.673
morphogenesis of embryonic epithelium GO:0016331 159 0.673
positive regulation of autophagy GO:0010508 9 0.664
Fly
regulation of cell size GO:0008361 72 0.663
Rat Fly
homeostasis of number of cells GO:0048872 210 0.625
cell growth GO:0016049 130 0.613
Fly
negative regulation of cell growth GO:0030308 44 0.605
Fly
tube formation GO:0035148 140 0.595
neuronal action potential GO:0019228 54 0.587
negative regulation of growth GO:0045926 99 0.585
Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.564
primary neural tube formation GO:0014020 95 0.558
neural tube formation GO:0001841 108 0.549
meiotic cell cycle GO:0051321 122 0.544
negative regulation of cellular protein metabolic process GO:0032269 247 0.536
epithelial tube formation GO:0072175 130 0.533
intracellular mrna localization GO:0008298 4 0.533
ubiquitin dependent protein catabolic process GO:0006511 129 0.526
tube closure GO:0060606 91 0.518
actomyosin structure organization GO:0031032 56 0.507
limbic system development GO:0021761 72 0.491
regulation of autophagy GO:0010506 30 0.485
Fly
dephosphorylation GO:0016311 129 0.454
regulation of cell growth GO:0001558 91 0.451
Fly
regulation of organelle organization GO:0033043 289 0.423
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.404
regulation of cellular catabolic process GO:0031329 242 0.403
Human Rat Fly
autophagy GO:0006914 45 0.400
Fly
pallium development GO:0021543 120 0.398
protein ubiquitination GO:0016567 171 0.394
urogenital system development GO:0001655 261 0.381
multicellular organismal signaling GO:0035637 91 0.375
cellular protein catabolic process GO:0044257 155 0.371
dna metabolic process GO:0006259 303 0.367
cell maturation GO:0048469 127 0.362
neural tube development GO:0021915 160 0.362
axon ensheathment GO:0008366 76 0.362
regulation of stress fiber assembly GO:0051492 15 0.355
organelle fission GO:0048285 170 0.353
modification dependent protein catabolic process GO:0019941 133 0.352
male gamete generation GO:0048232 285 0.349
negative regulation of glial cell proliferation GO:0060253 4 0.341
negative regulation of tor signaling GO:0032007 13 0.340
cerebral cortex development GO:0021987 86 0.337
regulation of anatomical structure size GO:0090066 178 0.332
Rat Fly
cellular response to dna damage stimulus GO:0006974 207 0.326
Fly
organ growth GO:0035265 117 0.326
Fly
kidney development GO:0001822 213 0.321
oocyte construction GO:0007308 2 0.319
muscle tissue development GO:0060537 308 0.310
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.309
Human Rat Fly
skin development GO:0043588 220 0.305
transmission of nerve impulse GO:0019226 76 0.302
negative regulation of dna replication GO:0008156 4 0.299
regulation of neuron differentiation GO:0045664 281 0.295
protein localization to organelle GO:0033365 185 0.295
nucleoside triphosphate metabolic process GO:0009141 230 0.295
Human Rat Fly
meiotic cell cycle process GO:1903046 77 0.290
negative regulation of protein metabolic process GO:0051248 282 0.283
camera type eye development GO:0043010 266 0.276
regulation of neural precursor cell proliferation GO:2000177 70 0.275
tor signaling GO:0031929 21 0.271
cell adhesion GO:0007155 329 0.271
muscle cell differentiation GO:0042692 261 0.269
regulation of ras protein signal transduction GO:0046578 114 0.269
Fly
pole plasm assembly GO:0007315 2 0.265
regulation of cell cycle GO:0051726 281 0.262
Rat Fly
regulation of transferase activity GO:0051338 263 0.258
regulation of reactive oxygen species metabolic process GO:2000377 40 0.255
renal system development GO:0072001 225 0.252
negative regulation of organ growth GO:0046621 17 0.251
Fly
regionalization GO:0003002 337 0.249
translation GO:0006412 93 0.240
skeletal system development GO:0001501 356 0.239
posttranscriptional regulation of gene expression GO:0010608 155 0.237
response to oxygen levels GO:0070482 62 0.236
aggresome assembly GO:0070842 2 0.235
positive regulation of organelle organization GO:0010638 128 0.229
intracellular protein transport GO:0006886 204 0.228
ensheathment of neurons GO:0007272 76 0.226
positive regulation of ras gtpase activity GO:0032320 65 0.225
Fly
spermatid differentiation GO:0048515 115 0.224
striated muscle tissue development GO:0014706 293 0.222
germ cell development GO:0007281 185 0.222
Fly
macroautophagy GO:0016236 21 0.215
negative regulation of molecular function GO:0044092 258 0.215
nucleoside triphosphate catabolic process GO:0009143 205 0.213
Human Rat Fly
myelination GO:0042552 74 0.211
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.211
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.210
rho protein signal transduction GO:0007266 32 0.209
sperm individualization GO:0007291 1 0.209
positive regulation of nucleotide catabolic process GO:0030813 88 0.208
Human Rat Fly
dna replication GO:0006260 52 0.207
regulation of mapk cascade GO:0043408 248 0.203
Rat
nucleocytoplasmic transport GO:0006913 139 0.202
regulation of protein localization GO:0032880 231 0.201
developmental maturation GO:0021700 193 0.201
regulation of nucleotide metabolic process GO:0006140 169 0.199
Human Rat Fly
guanosine containing compound metabolic process GO:1901068 144 0.199
Human Rat Fly
positive regulation of cellular catabolic process GO:0031331 148 0.198
Human Rat Fly
negative regulation of cell cycle GO:0045786 123 0.195
nuclear export GO:0051168 34 0.194
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.193
regulation of timing of cell differentiation GO:0048505 11 0.193
oxidation reduction process GO:0055114 342 0.192
regulation of cell adhesion GO:0030155 154 0.189
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.189
action potential GO:0001508 78 0.187
actin cytoskeleton organization GO:0030036 220 0.186
epithelial cell proliferation GO:0050673 174 0.186
Rat
actin filament bundle assembly GO:0051017 40 0.185
nucleobase containing small molecule metabolic process GO:0055086 352 0.185
Human Rat Fly
regulation of cytoskeleton organization GO:0051493 122 0.183
regulation of cellular component size GO:0032535 121 0.183
Rat Fly
ribonucleoside triphosphate catabolic process GO:0009203 199 0.182
Human Rat Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.182
regulation of actin filament based process GO:0032970 99 0.176
regulation of hippo signaling GO:0035330 1 0.176
spermatogenesis GO:0007283 284 0.175
negative regulation of gliogenesis GO:0014014 23 0.174
insulin receptor signaling pathway GO:0008286 49 0.173
negative regulation of tyrosine phosphorylation of stat5 protein GO:0042524 2 0.173
meiotic nuclear division GO:0007126 115 0.171
carbohydrate transport GO:0008643 62 0.170
protein modification by small protein conjugation GO:0032446 187 0.167
response to extracellular stimulus GO:0009991 127 0.166
Fly
oocyte anterior posterior axis specification GO:0007314 2 0.165
cellular response to decreased oxygen levels GO:0036294 18 0.164
Fly
positive regulation of cellular component biogenesis GO:0044089 94 0.158
regulation of cellular amino acid metabolic process GO:0006521 5 0.157
cellular amino acid metabolic process GO:0006520 103 0.157
mapk cascade GO:0000165 281 0.157
Rat
regulation of nucleoside metabolic process GO:0009118 130 0.153
Human Rat Fly
positive regulation of cell substrate adhesion GO:0010811 47 0.149
cell junction organization GO:0034330 77 0.147
covalent chromatin modification GO:0016569 163 0.146
protein stabilization GO:0050821 25 0.146
embryonic skeletal system development GO:0048706 120 0.145
regulation of protein kinase activity GO:0045859 232 0.145
regulation of cell substrate adhesion GO:0010810 73 0.143
female gamete generation GO:0007292 74 0.142
Fly
potassium ion transport GO:0006813 52 0.142
negative regulation of protein modification process GO:0031400 163 0.141
reactive oxygen species metabolic process GO:0072593 84 0.138
negative regulation of cell proliferation GO:0008285 296 0.135
proteasomal protein catabolic process GO:0010498 98 0.134
plasma membrane organization GO:0007009 90 0.133
regulation of protein stability GO:0031647 52 0.131
cellular response to hypoxia GO:0071456 17 0.128
Fly
cognition GO:0050890 149 0.127
protein processing GO:0016485 163 0.124
respiratory system development GO:0060541 190 0.122
regulation of rho gtpase activity GO:0032319 58 0.122
regulation of cellular ketone metabolic process GO:0010565 66 0.121
response to decreased oxygen levels GO:0036293 59 0.121
maternal determination of anterior posterior axis embryo GO:0008358 2 0.120
chromosome segregation GO:0007059 48 0.119
positive regulation of programmed cell death GO:0043068 218 0.118
cation transport GO:0006812 399 0.117
endocytosis GO:0006897 168 0.115
cell cell junction organization GO:0045216 72 0.114
muscle cell development GO:0055001 133 0.114
purine ribonucleotide metabolic process GO:0009150 290 0.114
Human Rat Fly
cellular macromolecule catabolic process GO:0044265 206 0.113
regulation of actin cytoskeleton organization GO:0032956 84 0.113
regulation of cellular response to insulin stimulus GO:1900076 30 0.113
negative regulation of nervous system development GO:0051961 156 0.113
Fly
rna localization GO:0006403 23 0.112
regulation of proteolysis GO:0030162 164 0.112
protein maturation GO:0051604 176 0.111
negative regulation of phosphorus metabolic process GO:0010563 184 0.110
gtp metabolic process GO:0046039 144 0.110
Human Rat Fly
nucleotide metabolic process GO:0009117 332 0.109
Human Rat Fly
regulation of neuron projection development GO:0010975 169 0.108
gtp catabolic process GO:0006184 143 0.108
Human Rat Fly
purine ribonucleoside catabolic process GO:0046130 205 0.108
Human Rat Fly
glucose transport GO:0015758 56 0.107
cellular response to peptide GO:1901653 92 0.107
regulation of cellular protein catabolic process GO:1903362 61 0.107
regulation of membrane potential GO:0042391 192 0.106
connective tissue development GO:0061448 179 0.106
oocyte development GO:0048599 33 0.105
cellular response to peptide hormone stimulus GO:0071375 92 0.104
synapsis GO:0007129 34 0.103
positive regulation of gtpase activity GO:0043547 85 0.103
Human Rat Fly
negative regulation of cellular amine metabolic process GO:0033239 1 0.103
cardiac muscle tissue development GO:0048738 130 0.102
regulation of cellular component biogenesis GO:0044087 181 0.102
Fly
glucose import GO:0046323 32 0.101
central nervous system neuron differentiation GO:0021953 162 0.100
anatomical structure homeostasis GO:0060249 145 0.100
mitotic cell cycle GO:0000278 195 0.099
oogenesis GO:0048477 56 0.098
Fly
synaptic transmission GO:0007268 329 0.098
Fly
guanosine containing compound catabolic process GO:1901069 144 0.097
Human Rat Fly
peptidyl tyrosine phosphorylation GO:0018108 143 0.097
positive regulation of nucleotide metabolic process GO:0045981 114 0.096
Human Rat Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.095
Human Rat Fly
regulation of rho protein signal transduction GO:0035023 71 0.094
purine nucleoside catabolic process GO:0006152 205 0.094
Human Rat Fly
positive regulation of hydrolase activity GO:0051345 148 0.093
Human Rat Fly
cell substrate adhesion GO:0031589 130 0.091
nucleoside catabolic process GO:0009164 206 0.090
Human Rat Fly
purine ribonucleoside metabolic process GO:0046128 241 0.089
Human Rat Fly
nucleic acid transport GO:0050657 18 0.089
respiratory tube development GO:0030323 167 0.086
actin filament organization GO:0007015 113 0.086
reproductive behavior GO:0019098 32 0.085
oocyte differentiation GO:0009994 35 0.085
nitrogen compound transport GO:0071705 271 0.084
photoreceptor cell differentiation GO:0046530 52 0.082
purine nucleoside triphosphate metabolic process GO:0009144 226 0.081
Human Rat Fly
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 1 0.080
cellular amine metabolic process GO:0044106 44 0.080
nuclear division GO:0000280 158 0.079
response to radiation GO:0009314 165 0.079
learning or memory GO:0007611 148 0.078
chromatin modification GO:0016568 187 0.078
regulation of kinase activity GO:0043549 249 0.078
amine metabolic process GO:0009308 45 0.078
citrate metabolic process GO:0006101 3 0.078
ribonucleotide metabolic process GO:0009259 291 0.078
Human Rat Fly
bone development GO:0060348 120 0.078
cell division GO:0051301 120 0.077
gliogenesis GO:0042063 141 0.077
activation of rho gtpase activity GO:0032862 7 0.076
protein localization to nucleus GO:0034504 121 0.075
apical protein localization GO:0045176 7 0.075
negative regulation of cell development GO:0010721 169 0.074
myeloid leukocyte differentiation GO:0002573 119 0.074
negative regulation of protein phosphorylation GO:0001933 126 0.073
axonogenesis GO:0007409 274 0.073
regulation of cell projection organization GO:0031344 206 0.072
angiogenesis GO:0001525 201 0.070
pigmentation GO:0043473 71 0.070
regulation of epithelial cell proliferation GO:0050678 141 0.070
Rat
positive regulation of macroautophagy GO:0016239 3 0.069
rna transport GO:0050658 18 0.069
positive regulation of rho gtpase activity GO:0032321 41 0.068
cellular response to insulin stimulus GO:0032869 78 0.068
membrane organization GO:0061024 245 0.067
aromatic compound catabolic process GO:0019439 286 0.067
Human Rat Fly
cellular response to growth factor stimulus GO:0071363 197 0.067
cellularization GO:0007349 1 0.067
regulation of cell cycle process GO:0010564 160 0.067
cellular lipid metabolic process GO:0044255 323 0.066
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.066
regulation of nucleotide catabolic process GO:0030811 122 0.066
Human Rat Fly
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.065
positive regulation of neuron differentiation GO:0045666 141 0.065
ribosome biogenesis GO:0042254 20 0.065
cellular glucan metabolic process GO:0006073 32 0.064
white fat cell proliferation GO:0070343 2 0.064
regulation of dephosphorylation GO:0035303 18 0.063
metencephalon development GO:0022037 89 0.062
branching morphogenesis of an epithelial tube GO:0048754 159 0.062
organonitrogen compound catabolic process GO:1901565 264 0.062
Human Rat Fly
single organismal cell cell adhesion GO:0016337 131 0.061
digestive system development GO:0055123 200 0.061
chromatin organization GO:0006325 206 0.061
regulation of adherens junction organization GO:1903391 12 0.061
purine containing compound metabolic process GO:0072521 311 0.061
Human Rat Fly
vacuole organization GO:0007033 38 0.060
nucleobase containing compound transport GO:0015931 27 0.060
myeloid cell homeostasis GO:0002262 114 0.059
activation of ras gtpase activity GO:0032856 11 0.059
regulation of cell motility GO:2000145 236 0.059
asymmetric protein localization GO:0008105 11 0.059
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.058
meiotic cytokinesis GO:0033206 5 0.058
regulation of exit from mitosis GO:0007096 1 0.058
regulation of purine nucleotide metabolic process GO:1900542 169 0.058
Human Rat Fly
cellular response to oxygen levels GO:0071453 20 0.057
Fly
negative regulation of phosphorylation GO:0042326 166 0.057
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.057
ribonucleotide catabolic process GO:0009261 208 0.057
Human Rat Fly
lymphocyte differentiation GO:0030098 242 0.057
schwann cell differentiation GO:0014037 26 0.057
regulation of gtp catabolic process GO:0033124 113 0.057
Human Rat Fly
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.056
cellular response to starvation GO:0009267 57 0.056
nucleoside phosphate metabolic process GO:0006753 338 0.056
Human Rat Fly
protein catabolic process GO:0030163 221 0.056
synapse organization GO:0050808 125 0.055
Fly
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.055
glycosyl compound metabolic process GO:1901657 246 0.055
Human Rat Fly
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.055
positive regulation of neuron projection development GO:0010976 79 0.054
myeloid cell differentiation GO:0030099 233 0.054
gland development GO:0048732 330 0.054
response to nutrient levels GO:0031667 109 0.054
Fly
carbohydrate derivative catabolic process GO:1901136 231 0.054
Human Rat Fly
regulation of protein maturation GO:1903317 96 0.053
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.053
glycosyl compound catabolic process GO:1901658 206 0.053
Human Rat Fly
ribonucleoside metabolic process GO:0009119 245 0.053
Human Rat Fly
molting cycle GO:0042303 90 0.052
regulation of body fluid levels GO:0050878 162 0.052
positive regulation of nucleoside metabolic process GO:0045979 91 0.052
Human Rat Fly
positive regulation of proteolysis GO:0045862 85 0.051
cerebellum development GO:0021549 77 0.051
microtubule cytoskeleton organization GO:0000226 157 0.051
negative regulation of translation GO:0017148 22 0.050
negative regulation of nuclear division GO:0051784 19 0.049
organelle assembly GO:0070925 177 0.049
synaptonemal complex assembly GO:0007130 13 0.049
positive regulation of cytoskeleton organization GO:0051495 49 0.049
regulation of cellular amine metabolic process GO:0033238 20 0.049
negative regulation of cell adhesion GO:0007162 45 0.049
negative regulation of kinase activity GO:0033673 81 0.049
neural precursor cell proliferation GO:0061351 121 0.049
regulation of nucleocytoplasmic transport GO:0046822 73 0.048
stem cell development GO:0048864 219 0.048
spermatid development GO:0007286 108 0.048
multicellular organismal reproductive behavior GO:0033057 23 0.048
response to peptide GO:1901652 136 0.048
vesicle localization GO:0051648 86 0.047
rhythmic process GO:0048511 174 0.047
sensory perception of umami taste GO:0050917 4 0.047
positive regulation of cell development GO:0010720 237 0.047
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.046
positive regulation of protein phosphorylation GO:0001934 242 0.046
Fly
regulation of actin filament bundle assembly GO:0032231 18 0.046
purine nucleoside metabolic process GO:0042278 241 0.045
Human Rat Fly
negative regulation of organelle organization GO:0010639 90 0.045
modification dependent macromolecule catabolic process GO:0043632 133 0.045
carbohydrate derivative biosynthetic process GO:1901137 183 0.045
cellular ketone metabolic process GO:0042180 84 0.045
jak stat cascade GO:0007259 42 0.045
epidermis development GO:0008544 187 0.044
regulation of protein catabolic process GO:0042176 108 0.044
meiosis i GO:0007127 60 0.044
organic cyclic compound catabolic process GO:1901361 295 0.044
Human Rat Fly
regulation of translation GO:0006417 71 0.044
chromosome organization involved in meiosis GO:0070192 39 0.044
eye photoreceptor cell differentiation GO:0001754 41 0.044
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.043
multicellular organismal aging GO:0010259 24 0.043
Fly
peptidyl tyrosine modification GO:0018212 145 0.043
small gtpase mediated signal transduction GO:0007264 97 0.043
cellular nitrogen compound catabolic process GO:0044270 280 0.042
Human Rat Fly
segmentation GO:0035282 93 0.042
response to organonitrogen compound GO:0010243 246 0.042
cell cycle arrest GO:0007050 37 0.042
regulation of gliogenesis GO:0014013 50 0.042
cellular response to hormone stimulus GO:0032870 150 0.041
regulation of hydrolase activity GO:0051336 246 0.041
Human Rat Fly
regulation of multi organism process GO:0043900 111 0.041
methylation GO:0032259 134 0.040
mesoderm formation GO:0001707 62 0.040
regulation of erk1 and erk2 cascade GO:0070372 71 0.040
establishment of rna localization GO:0051236 18 0.040
purine nucleotide metabolic process GO:0006163 302 0.040
Human Rat Fly
monocarboxylic acid metabolic process GO:0032787 191 0.040
purine containing compound catabolic process GO:0072523 213 0.040
Human Rat Fly
epithelial cell development GO:0002064 159 0.040
neuron projection extension GO:1990138 64 0.039
multi multicellular organism process GO:0044706 109 0.039
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.039
circulatory system process GO:0003013 197 0.039
adherens junction assembly GO:0034333 22 0.039
hindbrain development GO:0030902 128 0.038
positive regulation of cell cycle process GO:0090068 61 0.038
regulation of dna replication GO:0006275 17 0.038
sensory organ morphogenesis GO:0090596 242 0.038
positive regulation of adherens junction organization GO:1903393 5 0.038
cellular response to external stimulus GO:0071496 88 0.037
lipid biosynthetic process GO:0008610 179 0.037
response to starvation GO:0042594 65 0.036
cellular polysaccharide metabolic process GO:0044264 38 0.036
multicellular organismal homeostasis GO:0048871 164 0.036
cyclic nucleotide metabolic process GO:0009187 59 0.036
microtubule organizing center organization GO:0031023 28 0.036
regulation of jak stat cascade GO:0046425 34 0.036
fertilization GO:0009566 127 0.035
muscle fiber development GO:0048747 76 0.035
negative regulation of protein depolymerization GO:1901880 21 0.035
odontogenesis of dentin containing tooth GO:0042475 66 0.035
synaptonemal complex organization GO:0070193 15 0.035
single fertilization GO:0007338 82 0.035
negative regulation of cellular catabolic process GO:0031330 47 0.034
macromolecule methylation GO:0043414 120 0.034
negative regulation of cellular component organization GO:0051129 194 0.034
Fly
focal adhesion assembly GO:0048041 19 0.034
lung development GO:0030324 164 0.034
glandular epithelial cell differentiation GO:0002067 38 0.034
positive regulation of cell projection organization GO:0031346 95 0.034
axon guidance GO:0007411 141 0.034
skeletal system morphogenesis GO:0048705 203 0.034
cellular response to nutrient levels GO:0031669 64 0.033
regulation of nuclear division GO:0051783 56 0.033
establishment of skin barrier GO:0061436 14 0.033
myotube cell development GO:0014904 60 0.033
regulation of feeding behavior GO:0060259 3 0.033
histone modification GO:0016570 159 0.033
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.032
regulation of white fat cell proliferation GO:0070350 2 0.032
negative regulation of ligase activity GO:0051352 3 0.032
chemotaxis GO:0006935 247 0.032
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.032
regulation of proteasomal protein catabolic process GO:0061136 46 0.032
response to growth factor GO:0070848 198 0.032
ossification GO:0001503 216 0.032
positive regulation of stress fiber assembly GO:0051496 9 0.032
positive regulation of cell death GO:0010942 224 0.031
regulation of protein localization to nucleus GO:1900180 60 0.031
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.031
lens development in camera type eye GO:0002088 62 0.031
glial cell differentiation GO:0010001 131 0.031
regulation of blood pressure GO:0008217 93 0.031
negative regulation of mapk cascade GO:0043409 65 0.031
Rat
response to insulin GO:0032868 100 0.031
dendrite development GO:0016358 115 0.031
cardiac muscle cell differentiation GO:0055007 69 0.031
heart process GO:0003015 94 0.030
glycoprotein metabolic process GO:0009100 116 0.030
apoptotic signaling pathway GO:0097190 306 0.030
spindle localization GO:0051653 22 0.030
positive regulation of cell adhesion GO:0045785 80 0.030
nucleotide catabolic process GO:0009166 217 0.030
Human Rat Fly
formation of primary germ layer GO:0001704 77 0.029
engulfment of apoptotic cell GO:0043652 3 0.029
organonitrogen compound biosynthetic process GO:1901566 192 0.029
cellular homeostasis GO:0019725 240 0.029
oocyte maturation GO:0001556 18 0.029
hindbrain morphogenesis GO:0021575 46 0.029
maintenance of location GO:0051235 89 0.029
developmental pigmentation GO:0048066 40 0.028
multi organism reproductive behavior GO:0044705 29 0.028
regulation of mitotic cell cycle GO:0007346 126 0.028
nadh metabolic process GO:0006734 1 0.028
ribonucleoside catabolic process GO:0042454 206 0.028
Human Rat Fly
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.027
positive regulation of apoptotic process GO:0043065 217 0.027
tissue homeostasis GO:0001894 115 0.027
retina development in camera type eye GO:0060041 119 0.027
energy derivation by oxidation of organic compounds GO:0015980 77 0.027
peptidyl lysine modification GO:0018205 77 0.027
regulation of establishment of protein localization GO:0070201 181 0.027
regulation of axon extension GO:0030516 43 0.027
establishment of spindle orientation GO:0051294 15 0.027
purine nucleotide catabolic process GO:0006195 211 0.026
Human Rat Fly
cerebellum morphogenesis GO:0021587 42 0.026
regulation of mitosis GO:0007088 29 0.026
regulation of system process GO:0044057 200 0.026
dna modification GO:0006304 50 0.026
negative regulation of endothelial cell migration GO:0010596 4 0.026
regulation of skeletal muscle fiber development GO:0048742 36 0.026
regulation of cellular response to growth factor stimulus GO:0090287 82 0.026
muscle system process GO:0003012 141 0.026
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.026
regulation of apoptotic signaling pathway GO:2001233 197 0.026
hippo signaling GO:0035329 11 0.026
skeletal muscle organ development GO:0060538 163 0.026
endothelial cell migration GO:0043542 44 0.026
erythrocyte differentiation GO:0030218 88 0.025
cardiocyte differentiation GO:0035051 87 0.025
mitotic nuclear division GO:0007067 48 0.025
heparin biosynthetic process GO:0030210 2 0.025
innate immune response GO:0045087 157 0.025
generation of precursor metabolites and energy GO:0006091 103 0.025
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.025
response to temperature stimulus GO:0009266 55 0.024
photoreceptor cell development GO:0042461 40 0.024
response to inactivity GO:0014854 4 0.024
establishment of mitotic spindle orientation GO:0000132 12 0.024

Tsc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.309
cancer DOID:162 0 0.201
disease of anatomical entity DOID:7 0 0.049
nervous system disease DOID:863 0 0.049
organ system cancer DOID:0050686 0 0.041
benign neoplasm DOID:0060072 0 0.038
disease of metabolism DOID:0014667 0 0.032
large intestine cancer DOID:5672 0 0.030
colon cancer DOID:219 0 0.030
gastrointestinal system cancer DOID:3119 0 0.030
intestinal cancer DOID:10155 0 0.030
colorectal cancer DOID:9256 0 0.030
sensory system disease DOID:0050155 0 0.028
eye and adnexa disease DOID:1492 0 0.028
eye disease DOID:5614 0 0.028
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024