Mus musculus

126 known processes

Wdr5

WD repeat domain 5

(Aliases: AA408785,AA960360,Big-3,2410008O07Rik,Big)

Wdr5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 187 0.998
histone modification GO:0016570 159 0.996
histone methylation GO:0016571 71 0.996
macromolecule methylation GO:0043414 120 0.996
covalent chromatin modification GO:0016569 163 0.995
protein methylation GO:0006479 81 0.986
internal protein amino acid acetylation GO:0006475 42 0.984
Human Fly
chromatin organization GO:0006325 206 0.983
protein alkylation GO:0008213 81 0.980
histone acetylation GO:0016573 41 0.978
Human Fly
methylation GO:0032259 134 0.966
transdifferentiation GO:0060290 1 0.961
Worm
histone h3 k4 methylation GO:0051568 23 0.926
histone lysine methylation GO:0034968 50 0.850
peptidyl lysine modification GO:0018205 77 0.812
Human Fly
chromatin silencing GO:0006342 15 0.747
histone deubiquitination GO:0016578 2 0.677
dna metabolic process GO:0006259 303 0.659
peptidyl amino acid modification GO:0018193 336 0.629
Human Fly
mitotic cell cycle GO:0000278 195 0.589
Fly
gene silencing GO:0016458 38 0.534
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.534
internal peptidyl lysine acetylation GO:0018393 42 0.534
Human Fly
peptidyl lysine acetylation GO:0018394 45 0.521
Human Fly
chromatin mediated maintenance of transcription GO:0048096 2 0.476
cellular response to dna damage stimulus GO:0006974 207 0.421
Fly
histone h3 acetylation GO:0043966 14 0.402
Human
protein acylation GO:0043543 64 0.376
Human Fly
negative regulation of gene expression epigenetic GO:0045814 15 0.369
response to organic cyclic compound GO:0014070 198 0.339
positive regulation of gluconeogenesis by positive regulation of transcription from rna polymerase ii promoter GO:0035948 5 0.296
chromatin remodeling GO:0006338 32 0.261
Fly
segmentation GO:0035282 93 0.169
neural tube development GO:0021915 160 0.168
regionalization GO:0003002 337 0.167
intracellular receptor signaling pathway GO:0030522 74 0.160
histone h4 acetylation GO:0043967 10 0.146
Human
negative regulation of phosphorus metabolic process GO:0010563 184 0.131
leukocyte differentiation GO:0002521 342 0.130
protein deacetylation GO:0006476 32 0.126
embryonic organ morphogenesis GO:0048562 276 0.121
embryonic skeletal system morphogenesis GO:0048704 91 0.119
stem cell development GO:0048864 219 0.115
dendrite development GO:0016358 115 0.115
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.107
positive regulation of dna templated transcription elongation GO:0032786 2 0.103
blastocyst development GO:0001824 80 0.100
regulation of protein stability GO:0031647 52 0.099
signal transduction by p53 class mediator GO:0072331 51 0.095
cellular macromolecule catabolic process GO:0044265 206 0.094
transcription from rna polymerase i promoter GO:0006360 13 0.086
epithelial tube morphogenesis GO:0060562 303 0.084
cytoplasmic transport GO:0016482 234 0.084
regulation of transcription by chromatin organization GO:0034401 0 0.082
histone h3 k14 acetylation GO:0044154 3 0.081
histone h3 k9 acetylation GO:0043970 5 0.081
dna alkylation GO:0006305 43 0.079
dna methylation GO:0006306 43 0.079
response to estrogen GO:0043627 24 0.078
multi multicellular organism process GO:0044706 109 0.078
regulation of histone methylation GO:0031060 30 0.074
amine metabolic process GO:0009308 45 0.074
gland development GO:0048732 330 0.074
embryonic epithelial tube formation GO:0001838 130 0.074
response to steroid hormone GO:0048545 56 0.073
regulation of mitotic cell cycle GO:0007346 126 0.073
Fly
positive regulation of immature t cell proliferation GO:0033091 4 0.070
cellular ketone metabolic process GO:0042180 84 0.069
nuclear division GO:0000280 158 0.069
posttranscriptional regulation of gene expression GO:0010608 155 0.068
maturation of 5 8s rrna GO:0000460 1 0.068
anatomical structure homeostasis GO:0060249 145 0.065
blastocyst growth GO:0001832 23 0.064
protein targeting GO:0006605 143 0.063
negative regulation of molecular function GO:0044092 258 0.063
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.062
regulation of chromosome organization GO:0033044 83 0.061
histone h4 k12 acetylation GO:0043983 2 0.060
telomere maintenance GO:0000723 19 0.060
forebrain development GO:0030900 302 0.059
somitogenesis GO:0001756 69 0.057
germ cell development GO:0007281 185 0.057
mitotic cell cycle process GO:1903047 159 0.057
Fly
embryonic skeletal system development GO:0048706 120 0.056
ribonucleoside metabolic process GO:0009119 245 0.056
purine containing compound metabolic process GO:0072521 311 0.055
cellular amino acid metabolic process GO:0006520 103 0.055
response to oxidative stress GO:0006979 123 0.054
carbohydrate biosynthetic process GO:0016051 74 0.053
axon target recognition GO:0007412 4 0.053
morphogenesis of embryonic epithelium GO:0016331 159 0.052
establishment of protein localization to organelle GO:0072594 118 0.052
oogenesis GO:0048477 56 0.051
regulation of organelle organization GO:0033043 289 0.051
regulation of chromatin modification GO:1903308 57 0.050
neural tube closure GO:0001843 90 0.050
ribose phosphate metabolic process GO:0019693 291 0.050
gonad development GO:0008406 141 0.048
Worm
macromolecule catabolic process GO:0009057 281 0.048
regulation of cellular amino acid metabolic process GO:0006521 5 0.048
digestive tract development GO:0048565 190 0.047
hexose metabolic process GO:0019318 98 0.047
determination of adult lifespan GO:0008340 11 0.046
Worm
tube closure GO:0060606 91 0.045
regulation of carbohydrate biosynthetic process GO:0043255 40 0.045
purine nucleoside metabolic process GO:0042278 241 0.044
cellular carbohydrate metabolic process GO:0044262 119 0.044
ribonucleoside triphosphate catabolic process GO:0009203 199 0.042
regulation of histone modification GO:0031056 56 0.042
genitalia development GO:0048806 37 0.042
positive regulation of chromatin modification GO:1903310 28 0.041
positive regulation of gluconeogenesis GO:0045722 11 0.040
apoptotic signaling pathway GO:0097190 306 0.040
nucleoside phosphate metabolic process GO:0006753 338 0.040
regulation of nucleoside metabolic process GO:0009118 130 0.040
camera type eye development GO:0043010 266 0.039
nucleoside triphosphate catabolic process GO:0009143 205 0.039
skeletal system morphogenesis GO:0048705 203 0.039
neural tube formation GO:0001841 108 0.038
ribonucleotide metabolic process GO:0009259 291 0.038
regulation of cellular amine metabolic process GO:0033238 20 0.038
mitochondrion organization GO:0007005 134 0.037
lymphocyte differentiation GO:0030098 242 0.037
nucleocytoplasmic transport GO:0006913 139 0.036
nuclear transport GO:0051169 139 0.036
negative regulation of phosphorylation GO:0042326 166 0.036
cellular response to lipid GO:0071396 145 0.035
regulation of chromatin organization GO:1902275 57 0.035
regulation of intracellular transport GO:0032386 159 0.035
protein modification by small protein conjugation or removal GO:0070647 207 0.035
regulation of cellular ketone metabolic process GO:0010565 66 0.035
tube formation GO:0035148 140 0.035
response to organonitrogen compound GO:0010243 246 0.034
regulation of kinase activity GO:0043549 249 0.034
rna processing GO:0006396 105 0.034
male gamete generation GO:0048232 285 0.033
mesoderm development GO:0007498 100 0.033
nucleoside metabolic process GO:0009116 246 0.032
tubulin deacetylation GO:0090042 4 0.031
glycosyl compound metabolic process GO:1901657 246 0.030
negative regulation of cell proliferation GO:0008285 296 0.030
multicellular organism growth GO:0035264 161 0.030
organelle fission GO:0048285 170 0.030
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.030
stem cell maintenance GO:0019827 130 0.030
wnt signaling pathway GO:0016055 188 0.030
negative regulation of cell cycle GO:0045786 123 0.030
Fly
female gamete generation GO:0007292 74 0.030
monosaccharide biosynthetic process GO:0046364 44 0.029
positive regulation of transcription from rna polymerase i promoter GO:0045943 3 0.029
negative regulation of protein modification process GO:0031400 163 0.029
protein catabolic process GO:0030163 221 0.028
ribosomal small subunit biogenesis GO:0042274 4 0.028
histone h2a monoubiquitination GO:0035518 1 0.028
axonogenesis GO:0007409 274 0.028
male sex differentiation GO:0046661 109 0.028
developmental maturation GO:0021700 193 0.028
negative regulation of cellular component organization GO:0051129 194 0.027
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.027
small gtpase mediated signal transduction GO:0007264 97 0.026
cellular amine metabolic process GO:0044106 44 0.026
response to peptide GO:1901652 136 0.025
mrna splicing via spliceosome GO:0000398 43 0.025
homeostasis of number of cells GO:0048872 210 0.025
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.025
organonitrogen compound catabolic process GO:1901565 264 0.024
cell fate commitment GO:0045165 210 0.024
inner cell mass cell proliferation GO:0001833 15 0.024
sensory perception GO:0007600 245 0.023
regulation of cytoplasmic transport GO:1903649 112 0.023
regulation of cell cycle g1 s phase transition GO:1902806 35 0.023
regulation of mitotic cell cycle phase transition GO:1901990 73 0.023
Fly
nucleotide metabolic process GO:0009117 332 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
t cell activation GO:0042110 289 0.022
telencephalon development GO:0021537 186 0.021
negative regulation of phosphate metabolic process GO:0045936 184 0.021
urogenital system development GO:0001655 261 0.021
nucleoside monophosphate metabolic process GO:0009123 85 0.021
protein import into nucleus GO:0006606 95 0.021
regulation of intracellular protein transport GO:0033157 82 0.021
g1 s transition of mitotic cell cycle GO:0000082 57 0.021
nucleoside catabolic process GO:0009164 206 0.021
purine ribonucleoside metabolic process GO:0046128 241 0.021
histone h2a ubiquitination GO:0033522 3 0.021
regulation of leukocyte differentiation GO:1902105 159 0.021
meiosis i GO:0007127 60 0.021
skeletal system development GO:0001501 356 0.021
hindbrain development GO:0030902 128 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.020
spermatogenesis GO:0007283 284 0.020
response to light stimulus GO:0009416 135 0.020
regulation of glucose metabolic process GO:0010906 60 0.020
somite development GO:0061053 81 0.020
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
circadian regulation of gene expression GO:0032922 48 0.019
regulation of cell activation GO:0050865 289 0.019
purine nucleoside triphosphate catabolic process GO:0009146 203 0.019
positive regulation of b cell activation GO:0050871 49 0.019
response to acid chemical GO:0001101 111 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.019
protein localization to nucleus GO:0034504 121 0.018
positive regulation of cell activation GO:0050867 158 0.018
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.018
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.018
development of primary male sexual characteristics GO:0046546 88 0.018
primary neural tube formation GO:0014020 95 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
canonical wnt signaling pathway GO:0060070 130 0.017
mitotic nuclear division GO:0007067 48 0.017
nucleus organization GO:0006997 45 0.017
purine ribonucleotide metabolic process GO:0009150 290 0.017
gastrulation GO:0007369 116 0.017
monosaccharide metabolic process GO:0005996 106 0.017
cell adhesion GO:0007155 329 0.017
rna interference GO:0016246 2 0.017
ras protein signal transduction GO:0007265 77 0.017
stem cell differentiation GO:0048863 268 0.016
protein import GO:0017038 101 0.016
production of molecular mediator of immune response GO:0002440 103 0.016
purine nucleotide metabolic process GO:0006163 302 0.016
single organism nuclear import GO:1902593 95 0.016
regulation of purine nucleotide metabolic process GO:1900542 169 0.016
rrna processing GO:0006364 10 0.016
intracellular protein transport GO:0006886 204 0.016
rna 5 end processing GO:0000966 1 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
positive regulation of intracellular protein transport GO:0090316 42 0.016
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.016
leukocyte mediated immunity GO:0002443 174 0.016
regulation of t cell activation GO:0050863 170 0.016
regulation of cell cycle process GO:0010564 160 0.016
Fly
maintenance of location GO:0051235 89 0.015
connective tissue development GO:0061448 179 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
cell cycle g1 s phase transition GO:0044843 57 0.015
ossification GO:0001503 216 0.015
regulation of hydrolase activity GO:0051336 246 0.015
adaptive immune response GO:0002250 155 0.015
digestive system development GO:0055123 200 0.015
central nervous system neuron differentiation GO:0021953 162 0.015
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.015
nucleotide catabolic process GO:0009166 217 0.015
developmental growth involved in morphogenesis GO:0060560 138 0.015
negative regulation of protein metabolic process GO:0051248 282 0.015
cell maturation GO:0048469 127 0.015
purine nucleoside catabolic process GO:0006152 205 0.015
intracellular mrna localization GO:0008298 4 0.015
pharynx development GO:0060465 1 0.015
cell cycle arrest GO:0007050 37 0.015
cellular protein complex assembly GO:0043623 116 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
histone deacetylation GO:0016575 26 0.015
myeloid cell differentiation GO:0030099 233 0.015
response to peptide hormone GO:0043434 127 0.014
single organism cell adhesion GO:0098602 156 0.014
purine containing compound catabolic process GO:0072523 213 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
positive regulation of leukocyte mediated immunity GO:0002705 70 0.014
regulation of cellular catabolic process GO:0031329 242 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
branching morphogenesis of an epithelial tube GO:0048754 159 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
regulation of proteolysis GO:0030162 164 0.014
positive regulation of leukocyte differentiation GO:1902107 86 0.014
regulation of epithelial cell proliferation GO:0050678 141 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
rna catabolic process GO:0006401 29 0.014
cellular protein catabolic process GO:0044257 155 0.014
proteasomal protein catabolic process GO:0010498 98 0.014
chromatin silencing at rdna GO:0000183 3 0.014
blood vessel morphogenesis GO:0048514 285 0.014
striated muscle tissue development GO:0014706 293 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
demethylation GO:0070988 23 0.013
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 2 0.013
positive regulation of growth GO:0045927 104 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.013
digestive tract morphogenesis GO:0048546 147 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
hexose biosynthetic process GO:0019319 39 0.013
cell type specific apoptotic process GO:0097285 268 0.013
dna templated transcription elongation GO:0006354 13 0.013
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.013
regulation of mrna metabolic process GO:1903311 43 0.013
microtubule based process GO:0007017 236 0.013
atp metabolic process GO:0046034 75 0.013
histone h4 k16 acetylation GO:0043984 3 0.012
Human
muscle tissue development GO:0060537 308 0.012
cation transport GO:0006812 399 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.012
retina development in camera type eye GO:0060041 119 0.012
cellular response to acid chemical GO:0071229 68 0.012
protein ubiquitination GO:0016567 171 0.012
regulation of peptidyl lysine acetylation GO:2000756 22 0.012
positive regulation of lymphocyte differentiation GO:0045621 61 0.012
circulatory system process GO:0003013 197 0.012
locomotory behavior GO:0007626 195 0.012
cell activation involved in immune response GO:0002263 126 0.012
dna modification GO:0006304 50 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
heterocycle catabolic process GO:0046700 280 0.012
humoral immune response GO:0006959 57 0.012
positive regulation of protein modification process GO:0031401 299 0.012
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.012
meiotic cell cycle GO:0051321 122 0.012
snorna metabolic process GO:0016074 1 0.012
response to radiation GO:0009314 165 0.012
aromatic compound catabolic process GO:0019439 286 0.012
positive regulation of cell death GO:0010942 224 0.012
leukocyte proliferation GO:0070661 172 0.012
neuron death GO:0070997 154 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
negative regulation of cellular protein metabolic process GO:0032269 247 0.012
negative regulation of cell cycle process GO:0010948 69 0.012
Fly
positive regulation of carbohydrate metabolic process GO:0045913 30 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
negative regulation of ossification GO:0030279 49 0.012
double strand break repair GO:0006302 48 0.012
cellular response to organonitrogen compound GO:0071417 145 0.011
response to osmotic stress GO:0006970 21 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.011
positive regulation of lymphocyte activation GO:0051251 140 0.011
tissue remodeling GO:0048771 102 0.011
histone h3 k36 methylation GO:0010452 6 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
steroid metabolic process GO:0008202 119 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
epithelial cell proliferation GO:0050673 174 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
Fly
regulation of protein catabolic process GO:0042176 108 0.011
mammary gland epithelium development GO:0061180 65 0.011
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
regulation of histone h3 k36 methylation GO:0000414 1 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
maternal process involved in female pregnancy GO:0060135 32 0.011
wound healing GO:0042060 157 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
learning or memory GO:0007611 148 0.011
regulation of protein targeting GO:1903533 61 0.011
regulation of leukocyte proliferation GO:0070663 121 0.011
protein deubiquitination GO:0016579 19 0.011
regulation of antimicrobial humoral response GO:0002759 3 0.011
organic cyclic compound catabolic process GO:1901361 295 0.010
tricuspid valve development GO:0003175 3 0.010
mrna transcription GO:0009299 4 0.010
cleavage involved in rrna processing GO:0000469 1 0.010
respiratory system development GO:0060541 190 0.010
regulation of protein processing GO:0070613 96 0.010
positive regulation of hydrolase activity GO:0051345 148 0.010
regulation of cell migration GO:0030334 219 0.010
mapk cascade GO:0000165 281 0.010
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.010
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.010
protein localization to organelle GO:0033365 185 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010
t cell differentiation GO:0030217 174 0.010
regulation of lymphocyte mediated immunity GO:0002706 84 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.010
metaphase plate congression GO:0051310 2 0.010
protein modification by small protein conjugation GO:0032446 187 0.010

Wdr5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.052
sensory system disease DOID:0050155 0 0.030
eye and adnexa disease DOID:1492 0 0.030
eye disease DOID:5614 0 0.028
central nervous system disease DOID:331 0 0.021
retinal disease DOID:5679 0 0.014
retinal degeneration DOID:8466 0 0.014
disease of mental health DOID:150 0 0.012
neurodegenerative disease DOID:1289 0 0.011