Mus musculus

12 known processes

Wfdc12

WAP four-disulfide core domain 12

(Aliases: MGC32134,WAP2,Swam2)

Wfdc12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of programmed cell death GO:0043068 218 0.254
negative regulation of cell proliferation GO:0008285 296 0.251
immune effector process GO:0002252 321 0.171
inflammatory response GO:0006954 244 0.164
cellular lipid metabolic process GO:0044255 323 0.125
negative regulation of molecular function GO:0044092 258 0.112
positive regulation of apoptotic process GO:0043065 217 0.101
protein maturation GO:0051604 176 0.088
defense response to bacterium GO:0042742 119 0.088
myeloid leukocyte differentiation GO:0002573 119 0.087
cytokine mediated signaling pathway GO:0019221 115 0.084
response to organonitrogen compound GO:0010243 246 0.077
regulation of lipid metabolic process GO:0019216 118 0.069
epithelial cell proliferation GO:0050673 174 0.064
gland development GO:0048732 330 0.064
regulation of hormone levels GO:0010817 211 0.060
skeletal muscle fiber development GO:0048741 58 0.060
positive regulation of cell death GO:0010942 224 0.059
regulation of endopeptidase activity GO:0052548 89 0.057
lipid biosynthetic process GO:0008610 179 0.057
cellular ketone metabolic process GO:0042180 84 0.057
steroid metabolic process GO:0008202 119 0.056
cell type specific apoptotic process GO:0097285 268 0.054
striated muscle cell development GO:0055002 125 0.052
regulation of cellular ketone metabolic process GO:0010565 66 0.051
positive regulation of secretion by cell GO:1903532 114 0.049
myeloid cell differentiation GO:0030099 233 0.049
protein processing GO:0016485 163 0.048
cellular amino acid metabolic process GO:0006520 103 0.048
carbohydrate derivative biosynthetic process GO:1901137 183 0.047
carbohydrate metabolic process GO:0005975 230 0.047
negative regulation of cell activation GO:0050866 111 0.047
cation transport GO:0006812 399 0.046
monosaccharide metabolic process GO:0005996 106 0.043
regulation of epithelial cell proliferation GO:0050678 141 0.042
regulation of peptidase activity GO:0052547 96 0.042
regulation of proteolysis GO:0030162 164 0.041
negative regulation of hydrolase activity GO:0051346 71 0.040
negative regulation of phosphate metabolic process GO:0045936 184 0.039
hormone metabolic process GO:0042445 86 0.039
regulation of transferase activity GO:0051338 263 0.039
interspecies interaction between organisms GO:0044419 83 0.039
regulation of cellular amino acid metabolic process GO:0006521 5 0.039
regulation of protein processing GO:0070613 96 0.039
multicellular organismal homeostasis GO:0048871 164 0.038
regulation of lymphocyte activation GO:0051249 240 0.038
cation homeostasis GO:0055080 212 0.038
production of molecular mediator of immune response GO:0002440 103 0.038
cell division GO:0051301 120 0.038
negative regulation of protein processing GO:0010955 79 0.038
metal ion homeostasis GO:0055065 189 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
morphogenesis of a branching epithelium GO:0061138 193 0.037
regulation of ion homeostasis GO:2000021 64 0.036
response to acid chemical GO:0001101 111 0.036
muscle cell development GO:0055001 133 0.036
positive regulation of secretion GO:0051047 130 0.035
response to insulin GO:0032868 100 0.034
amide transport GO:0042886 138 0.034
organic hydroxy compound metabolic process GO:1901615 203 0.033
glycoprotein biosynthetic process GO:0009101 89 0.033
striated muscle tissue development GO:0014706 293 0.033
regulation of secretion by cell GO:1903530 249 0.033
placenta development GO:0001890 140 0.033
myotube differentiation GO:0014902 105 0.033
transmembrane transport GO:0055085 412 0.032
cellular chemical homeostasis GO:0055082 215 0.032
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
cellular response to organonitrogen compound GO:0071417 145 0.032
cell adhesion GO:0007155 329 0.031
neuron apoptotic process GO:0051402 142 0.031
extrinsic apoptotic signaling pathway GO:0097191 126 0.031
regulation of membrane potential GO:0042391 192 0.031
muscle cell differentiation GO:0042692 261 0.031
small gtpase mediated signal transduction GO:0007264 97 0.031
amine metabolic process GO:0009308 45 0.031
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.031
cellular response to cytokine stimulus GO:0071345 189 0.031
morphogenesis of a branching structure GO:0001763 203 0.030
calcium ion homeostasis GO:0055074 127 0.030
regulation of feeding behavior GO:0060259 3 0.030
hematopoietic progenitor cell differentiation GO:0002244 143 0.030
nitrogen compound transport GO:0071705 271 0.030
peptide transport GO:0015833 133 0.030
defense response to other organism GO:0098542 197 0.029
leukocyte proliferation GO:0070661 172 0.029
cell activation involved in immune response GO:0002263 126 0.029
negative regulation of immune system process GO:0002683 209 0.029
respiratory tube development GO:0030323 167 0.028
negative regulation of endopeptidase activity GO:0010951 44 0.027
cellular ion homeostasis GO:0006873 165 0.027
response to peptide GO:1901652 136 0.027
response to peptide hormone GO:0043434 127 0.027
regulation of hemostasis GO:1900046 28 0.027
reactive oxygen species metabolic process GO:0072593 84 0.026
leukocyte activation involved in immune response GO:0002366 126 0.026
adaptive immune response GO:0002250 155 0.026
epithelial tube morphogenesis GO:0060562 303 0.026
b cell activation GO:0042113 161 0.025
apoptotic signaling pathway GO:0097190 306 0.025
muscle fiber development GO:0048747 76 0.025
anatomical structure homeostasis GO:0060249 145 0.025
lymphocyte activation involved in immune response GO:0002285 93 0.025
hair follicle development GO:0001942 85 0.025
regulation of skeletal muscle fiber development GO:0048742 36 0.025
skeletal system morphogenesis GO:0048705 203 0.025
regulation of cellular response to stress GO:0080135 159 0.025
blood coagulation GO:0007596 76 0.025
mature natural killer cell chemotaxis GO:0035782 1 0.025
regulation of secretion GO:0051046 274 0.024
positive regulation of leukocyte differentiation GO:1902107 86 0.024
cellular response to dna damage stimulus GO:0006974 207 0.024
cellular homeostasis GO:0019725 240 0.024
negative regulation of protein metabolic process GO:0051248 282 0.024
fatty acid metabolic process GO:0006631 121 0.024
organelle fission GO:0048285 170 0.024
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.024
blood circulation GO:0008015 195 0.024
homeostasis of number of cells GO:0048872 210 0.024
divalent inorganic cation homeostasis GO:0072507 138 0.024
regulation of homeostatic process GO:0032844 182 0.023
glycerolipid metabolic process GO:0046486 122 0.023
regulation of keratinocyte differentiation GO:0045616 11 0.023
steroid biosynthetic process GO:0006694 47 0.023
branching morphogenesis of an epithelial tube GO:0048754 159 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.023
respiratory system development GO:0060541 190 0.022
epithelial cell development GO:0002064 159 0.022
multicellular organism growth GO:0035264 161 0.022
intrinsic apoptotic signaling pathway GO:0097193 132 0.022
extracellular matrix organization GO:0030198 147 0.021
male gamete generation GO:0048232 285 0.021
negative regulation of proteolysis GO:0045861 74 0.021
regulation of cytokine production GO:0001817 266 0.021
positive regulation of cell motility GO:2000147 116 0.020
regulation of protein maturation GO:1903317 96 0.020
regulation of angiogenesis GO:0045765 81 0.020
response to organic cyclic compound GO:0014070 198 0.020
regulation of organelle organization GO:0033043 289 0.020
regulation of response to wounding GO:1903034 189 0.020
wound healing GO:0042060 157 0.020
cytokine production GO:0001816 319 0.020
cellular response to hormone stimulus GO:0032870 150 0.020
cellular response to acid chemical GO:0071229 68 0.020
lipid localization GO:0010876 126 0.019
lipid catabolic process GO:0016042 69 0.019
triglyceride metabolic process GO:0006641 51 0.019
vascular process in circulatory system GO:0003018 62 0.019
positive regulation of protein kinase activity GO:0045860 144 0.019
regulation of defense response GO:0031347 233 0.019
cellular amine metabolic process GO:0044106 44 0.019
defense response to gram positive bacterium GO:0050830 50 0.019
regulation of protein catabolic process GO:0042176 108 0.019
regulation of cell migration GO:0030334 219 0.018
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.018
fatty acid biosynthetic process GO:0006633 41 0.018
regulation of leukocyte differentiation GO:1902105 159 0.018
circulatory system process GO:0003013 197 0.018
anion transport GO:0006820 177 0.018
positive regulation of cytokine secretion GO:0050715 41 0.018
heterocycle catabolic process GO:0046700 280 0.018
response to oxygen levels GO:0070482 62 0.018
negative regulation of lymphocyte activation GO:0051250 91 0.017
spermatid development GO:0007286 108 0.017
regulation of blood coagulation GO:0030193 28 0.017
regulation of hydrolase activity GO:0051336 246 0.017
regulation of renal sodium excretion GO:0035813 3 0.017
ossification GO:0001503 216 0.017
leukocyte differentiation GO:0002521 342 0.017
negative regulation of multi organism process GO:0043901 68 0.017
embryonic skeletal system development GO:0048706 120 0.017
cell maturation GO:0048469 127 0.017
lymphocyte proliferation GO:0046651 164 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
monocarboxylic acid metabolic process GO:0032787 191 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
digestive tract development GO:0048565 190 0.017
peptidyl amino acid modification GO:0018193 336 0.017
cellularization GO:0007349 1 0.017
embryonic skeletal system morphogenesis GO:0048704 91 0.017
regulation of cell motility GO:2000145 236 0.017
regulation of establishment of protein localization GO:0070201 181 0.017
regulation of body fluid levels GO:0050878 162 0.016
keratinocyte differentiation GO:0030216 48 0.016
odontogenesis GO:0042476 78 0.016
skeletal system development GO:0001501 356 0.016
leukocyte migration GO:0050900 124 0.016
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.016
regulation of cell cycle process GO:0010564 160 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.016
cellular response to inorganic substance GO:0071241 37 0.016
cytokine production involved in immune response GO:0002367 34 0.016
tissue homeostasis GO:0001894 115 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
innate immune response GO:0045087 157 0.016
viral process GO:0016032 41 0.016
cellular response to peptide hormone stimulus GO:0071375 92 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
negative regulation of protein maturation GO:1903318 79 0.016
membrane lipid biosynthetic process GO:0046467 32 0.016
positive regulation of cell development GO:0010720 237 0.016
spermatogenesis GO:0007283 284 0.016
positive regulation of cellular ph reduction GO:0032849 2 0.016
purine nucleotide metabolic process GO:0006163 302 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.015
negative regulation of epithelial cell proliferation GO:0050680 64 0.015
myotube cell development GO:0014904 60 0.015
adult behavior GO:0030534 135 0.015
macromolecule catabolic process GO:0009057 281 0.015
monocarboxylic acid biosynthetic process GO:0072330 61 0.015
stem cell proliferation GO:0072089 117 0.015
extracellular structure organization GO:0043062 148 0.015
b cell differentiation GO:0030183 78 0.015
regulation of systemic arterial blood pressure GO:0003073 61 0.015
lymphocyte apoptotic process GO:0070227 54 0.015
cellular response to insulin stimulus GO:0032869 78 0.015
endocrine system development GO:0035270 98 0.015
regulation of epidermal cell differentiation GO:0045604 21 0.014
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
sensory perception GO:0007600 245 0.014
rhythmic process GO:0048511 174 0.014
regulation of inflammatory response GO:0050727 147 0.014
translation GO:0006412 93 0.014
alpha beta t cell differentiation GO:0046632 69 0.014
cellular response to tumor necrosis factor GO:0071356 21 0.014
cellular modified amino acid metabolic process GO:0006575 63 0.014
glycosylation GO:0070085 62 0.014
cellular response to amino acid stimulus GO:0071230 29 0.014
sterol metabolic process GO:0016125 58 0.014
cd4 positive alpha beta t cell activation GO:0035710 45 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.014
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.014
muscle tissue development GO:0060537 308 0.014
sodium ion transport GO:0006814 73 0.014
glycoprotein metabolic process GO:0009100 116 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
epidermis development GO:0008544 187 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
protein catabolic process GO:0030163 221 0.013
lung development GO:0030324 164 0.013
nucleotide metabolic process GO:0009117 332 0.013
oxidation reduction process GO:0055114 342 0.013
positive regulation of angiogenesis GO:0045766 46 0.013
regulation of lipid biosynthetic process GO:0046890 54 0.013
myeloid cell homeostasis GO:0002262 114 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
positive regulation of lipid metabolic process GO:0045834 40 0.013
negative regulation of growth GO:0045926 99 0.013
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.013
leukocyte homeostasis GO:0001776 79 0.013
negative regulation of transferase activity GO:0051348 85 0.013
positive regulation of cell cycle process GO:0090068 61 0.013
leukocyte apoptotic process GO:0071887 71 0.013
response to inorganic substance GO:0010035 96 0.013
positive regulation of t cell activation GO:0050870 101 0.013
regulation of hormone secretion GO:0046883 88 0.013
regulation of epidermis development GO:0045682 33 0.013
epidermis morphogenesis GO:0048730 33 0.013
digestive system development GO:0055123 200 0.013
positive regulation of cell cycle GO:0045787 92 0.013
positive regulation of defense response GO:0031349 124 0.013
regulation of ion transport GO:0043269 215 0.013
fat cell differentiation GO:0045444 160 0.013
cellular response to organic cyclic compound GO:0071407 87 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
lymphocyte differentiation GO:0030098 242 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
peptide secretion GO:0002790 114 0.012
regulation of production of molecular mediator of immune response GO:0002700 65 0.012
sperm egg recognition GO:0035036 37 0.012
regulation of fat cell differentiation GO:0045598 81 0.012
carbohydrate biosynthetic process GO:0016051 74 0.012
renal sodium excretion GO:0035812 3 0.012
response to oxidative stress GO:0006979 123 0.012
skeletal muscle organ development GO:0060538 163 0.012
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.012
glucocorticoid metabolic process GO:0008211 9 0.012
phospholipid metabolic process GO:0006644 87 0.012
purine nucleotide catabolic process GO:0006195 211 0.012
hair follicle morphogenesis GO:0031069 29 0.012
negative regulation of peptidase activity GO:0010466 46 0.012
t cell differentiation GO:0030217 174 0.012
phosphatidylinositol mediated signaling GO:0048015 41 0.012
blood vessel morphogenesis GO:0048514 285 0.012
regulation of peptide transport GO:0090087 91 0.012
protein localization to organelle GO:0033365 185 0.012
protein glycosylation GO:0006486 55 0.012
neutral lipid metabolic process GO:0006638 57 0.012
mature dendritic cell differentiation GO:0097029 3 0.012
positive regulation of vasoconstriction GO:0045907 4 0.012
activation of adenylate cyclase activity GO:0007190 4 0.012
cholesterol metabolic process GO:0008203 56 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
peptide hormone secretion GO:0030072 109 0.012
coagulation GO:0050817 78 0.012
positive regulation of cytokine production GO:0001819 174 0.012
t cell activation involved in immune response GO:0002286 43 0.012
intracellular protein transport GO:0006886 204 0.012
bone morphogenesis GO:0060349 78 0.012
hormone secretion GO:0046879 128 0.012
ribonucleoside metabolic process GO:0009119 245 0.011
action potential GO:0001508 78 0.011
positive regulation of leukocyte mediated immunity GO:0002705 70 0.011
fertilization GO:0009566 127 0.011
response to amino acid GO:0043200 37 0.011
syncytium formation GO:0006949 43 0.011
negative regulation of lymphocyte differentiation GO:0045620 32 0.011
protein activation cascade GO:0072376 19 0.011
cellular response to peptide GO:1901653 92 0.011
positive regulation of neural precursor cell proliferation GO:2000179 42 0.011
chromatin organization GO:0006325 206 0.011
regulation of cellular amine metabolic process GO:0033238 20 0.011
appendage morphogenesis GO:0035107 149 0.011
angiogenesis GO:0001525 201 0.011
nucleobase containing small molecule metabolic process GO:0055086 352 0.011
nucleoside metabolic process GO:0009116 246 0.011
regulation of system process GO:0044057 200 0.011
mammary gland morphogenesis GO:0060443 54 0.011
wnt signaling pathway GO:0016055 188 0.011
binding of sperm to zona pellucida GO:0007339 34 0.011
multi multicellular organism process GO:0044706 109 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
gliogenesis GO:0042063 141 0.011
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.011
single organism cell adhesion GO:0098602 156 0.011
sequestering of calcium ion GO:0051208 18 0.011
regulation of translation GO:0006417 71 0.011
regulation of protein localization GO:0032880 231 0.011
protein secretion GO:0009306 111 0.011
compound eye development GO:0048749 1 0.011
cellular response to lipid GO:0071396 145 0.011
locomotory behavior GO:0007626 195 0.011
regulation of binding GO:0051098 111 0.011
regulation of kidney development GO:0090183 40 0.010
regulation of steroid metabolic process GO:0019218 39 0.010
lymphocyte homeostasis GO:0002260 64 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.010
intestinal epithelial cell differentiation GO:0060575 14 0.010
purine nucleotide biosynthetic process GO:0006164 65 0.010
mapk cascade GO:0000165 281 0.010
peptidyl tyrosine phosphorylation GO:0018108 143 0.010
germ cell development GO:0007281 185 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
membrane lipid metabolic process GO:0006643 53 0.010
axon ensheathment GO:0008366 76 0.010
production of molecular mediator involved in inflammatory response GO:0002532 21 0.010
regulation of metal ion transport GO:0010959 106 0.010
monovalent inorganic cation homeostasis GO:0055067 33 0.010
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.010
positive regulation of hydrolase activity GO:0051345 148 0.010
inorganic ion transmembrane transport GO:0098660 234 0.010
nucleoside phosphate catabolic process GO:1901292 222 0.010
ribonucleotide catabolic process GO:0009261 208 0.010
aromatic compound catabolic process GO:0019439 286 0.010
ribose phosphate metabolic process GO:0019693 291 0.010
regulation of blood pressure GO:0008217 93 0.010

Wfdc12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
musculoskeletal system disease DOID:17 0 0.022
connective tissue disease DOID:65 0 0.022
disease of metabolism DOID:0014667 0 0.014