Rattus norvegicus

19 known processes

Sp4

Sp4 transcription factor

(Aliases: HF-1b)

Sp4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron projection development GO:0031175 273 0.570
cell projection organization GO:0030030 302 0.408
tissue development GO:0009888 252 0.364
transcription dna templated GO:0006351 377 0.244
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.241
cellular component morphogenesis GO:0032989 155 0.239
rna biosynthetic process GO:0032774 380 0.217
regulation of transcription dna templated GO:0006355 374 0.216
regulation of nucleic acid templated transcription GO:1903506 380 0.169
circulatory system development GO:0072359 134 0.168
neuron development GO:0048666 286 0.164
reproduction GO:0000003 245 0.159
positive regulation of synaptic vesicle exocytosis GO:2000302 3 0.156
anatomical structure morphogenesis GO:0009653 298 0.156
positive regulation of transcription dna templated GO:0045893 197 0.151
regulation of rna metabolic process GO:0051252 391 0.140
axon development GO:0061564 96 0.139
transcription from rna polymerase ii promoter GO:0006366 252 0.136
cell part morphogenesis GO:0032990 123 0.128
neuron differentiation GO:0030182 368 0.126
transmembrane transport GO:0055085 412 0.123
single organism reproductive process GO:0044702 297 0.123
multicellular organismal reproductive process GO:0048609 233 0.122
apoptotic process GO:0006915 381 0.121
cardiovascular system development GO:0072358 134 0.118
synaptic transmission GO:0007268 235 0.116
positive regulation of developmental process GO:0051094 283 0.116
cellular component assembly GO:0022607 360 0.109
rna metabolic process GO:0016070 406 0.106
multi organism reproductive process GO:0044703 262 0.105
cell projection morphogenesis GO:0048858 123 0.103
regulation of cell development GO:0060284 263 0.097
protein localization GO:0008104 191 0.096
regulation of protein metabolic process GO:0051246 289 0.095
multicellular organism reproduction GO:0032504 233 0.094
nucleic acid templated transcription GO:0097659 379 0.092
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.088
positive regulation of gene expression GO:0010628 244 0.084
cell motility GO:0048870 202 0.084
neuron projection morphogenesis GO:0048812 122 0.081
macromolecular complex subunit organization GO:0043933 339 0.080
positive regulation of secretion GO:0051047 140 0.073
regulation of rna biosynthetic process GO:2001141 381 0.072
inorganic ion transmembrane transport GO:0098660 229 0.072
regulation of nervous system development GO:0051960 264 0.071
regulation of multicellular organismal development GO:2000026 376 0.071
positive regulation of multicellular organismal process GO:0051240 387 0.070
behavior GO:0007610 205 0.070
male mating behavior GO:0060179 3 0.070
locomotion GO:0040011 237 0.069
dendrite morphogenesis GO:0048813 43 0.068
regulation of cell projection organization GO:0031344 175 0.068
epithelial cell differentiation GO:0030855 71 0.067
cellular component biogenesis GO:0044085 368 0.067
cell morphogenesis GO:0000902 142 0.067
negative regulation of metabolic process GO:0009892 331 0.065
positive regulation of cellular component organization GO:0051130 200 0.065
negative regulation of gene expression GO:0010629 199 0.065
regulation of cellular component organization GO:0051128 368 0.064
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.062
cell adhesion GO:0007155 110 0.062
positive regulation of cell projection organization GO:0031346 111 0.061
establishment of vesicle localization GO:0051650 31 0.060
protein complex assembly GO:0006461 263 0.060
epithelium development GO:0060429 96 0.060
positive regulation of nervous system development GO:0051962 178 0.059
regulation of cellular localization GO:0060341 263 0.059
wound healing GO:0042060 122 0.059
regulation of system process GO:0044057 208 0.056
regulation of cellular protein metabolic process GO:0032268 267 0.056
cellular component movement GO:0006928 248 0.056
programmed cell death GO:0012501 392 0.055
protein complex biogenesis GO:0070271 263 0.055
gamete generation GO:0007276 124 0.055
cell morphogenesis involved in differentiation GO:0000904 119 0.054
reproductive process GO:0022414 372 0.054
organelle localization GO:0051640 55 0.053
regulation of ion transport GO:0043269 245 0.053
positive regulation of synaptic vesicle transport GO:1902805 3 0.052
macromolecular complex assembly GO:0065003 273 0.052
localization of cell GO:0051674 202 0.051
response to nutrient GO:0007584 248 0.051
establishment of organelle localization GO:0051656 37 0.051
cellular macromolecule localization GO:0070727 122 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
positive regulation of neuron projection development GO:0010976 99 0.049
macromolecule localization GO:0033036 252 0.049
cation transmembrane transport GO:0098655 263 0.049
positive regulation of cell differentiation GO:0045597 217 0.049
intracellular transport GO:0046907 185 0.049
inorganic cation transmembrane transport GO:0098662 202 0.049
regulation of response to stress GO:0080134 126 0.049
organ morphogenesis GO:0009887 75 0.048
protein complex subunit organization GO:0071822 302 0.048
cellular response to peptide GO:1901653 133 0.048
central nervous system development GO:0007417 311 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
response to extracellular stimulus GO:0009991 380 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
cell cell signaling GO:0007267 335 0.044
monovalent inorganic cation transport GO:0015672 172 0.044
organelle organization GO:0006996 266 0.044
positive regulation of neurogenesis GO:0050769 165 0.043
axonogenesis GO:0007409 71 0.043
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.042
positive regulation of rna metabolic process GO:0051254 203 0.041
dendrite development GO:0016358 72 0.041
positive regulation of neuron differentiation GO:0045666 126 0.041
actin filament based process GO:0030029 86 0.041
positive regulation of molecular function GO:0044093 230 0.041
alternative mrna splicing via spliceosome GO:0000380 4 0.041
negative regulation of biosynthetic process GO:0009890 168 0.041
regulation of locomotion GO:0040012 148 0.040
regulation of cell differentiation GO:0045595 320 0.039
cell migration GO:0016477 197 0.039
regulation of neuron projection development GO:0010975 161 0.039
developmental process involved in reproduction GO:0003006 159 0.039
regulation of apoptotic process GO:0042981 335 0.039
taxis GO:0042330 67 0.038
secretion by cell GO:0032940 248 0.038
developmental growth GO:0048589 100 0.037
regulation of neurogenesis GO:0050767 247 0.037
neuromuscular synaptic transmission GO:0007274 2 0.037
heart development GO:0007507 72 0.037
cellular response to stress GO:0033554 269 0.037
brain development GO:0007420 247 0.036
ion transmembrane transport GO:0034220 365 0.036
positive regulation of transport GO:0051050 245 0.035
receptor localization to synapse GO:0097120 2 0.035
biological adhesion GO:0022610 110 0.035
response to growth factor GO:0070848 189 0.035
positive regulation of cell death GO:0010942 184 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
negative regulation of cellular protein metabolic process GO:0032269 106 0.034
response to peptide hormone GO:0043434 278 0.034
rhythmic process GO:0048511 156 0.033
axis specification GO:0009798 4 0.032
regulation of signal transduction GO:0009966 318 0.032
regulation of programmed cell death GO:0043067 341 0.032
sexual reproduction GO:0019953 148 0.032
response to ketone GO:1901654 182 0.032
intracellular signal transduction GO:0035556 314 0.032
muscle system process GO:0003012 115 0.031
ras protein signal transduction GO:0007265 29 0.031
positive regulation of cell development GO:0010720 176 0.031
negative regulation of nucleic acid templated transcription GO:1903507 117 0.031
head development GO:0060322 247 0.031
response to hypoxia GO:0001666 231 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.031
response to wounding GO:0009611 254 0.030
neurological system process GO:0050877 219 0.030
embryonic pattern specification GO:0009880 1 0.030
multicellular organism growth GO:0035264 1 0.030
circadian rhythm GO:0007623 88 0.030
regulation of cellular component biogenesis GO:0044087 86 0.029
anterior posterior pattern specification GO:0009952 1 0.029
synaptic growth at neuromuscular junction GO:0051124 1 0.028
cation transport GO:0006812 382 0.028
aging GO:0007568 241 0.028
response to metal ion GO:0010038 253 0.028
response to nutrient levels GO:0031667 370 0.027
positive regulation of cell communication GO:0010647 271 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
lipid metabolic process GO:0006629 283 0.026
carboxylic acid metabolic process GO:0019752 289 0.026
ovulation cycle GO:0042698 67 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.026
positive regulation of biosynthetic process GO:0009891 319 0.026
regulation of synaptic transmission GO:0050804 141 0.026
single organism organelle organization GO:1902589 180 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
cellular response to endogenous stimulus GO:0071495 377 0.025
potassium ion transmembrane transport GO:0071805 71 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
deoxyribonucleoside monophosphate metabolic process GO:0009162 6 0.024
melanocyte differentiation GO:0030318 2 0.023
response to estrogen GO:0043627 232 0.023
cellular protein localization GO:0034613 122 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
response to ethanol GO:0045471 162 0.022
cellular catabolic process GO:0044248 295 0.022
positive regulation of nucleic acid templated transcription GO:1903508 197 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
regulation of mrna splicing via spliceosome GO:0048024 3 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
dna metabolic process GO:0006259 96 0.022
positive regulation of ion transport GO:0043270 94 0.022
deoxyribonucleoside monophosphate biosynthetic process GO:0009157 4 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
negative regulation of transcription dna templated GO:0045892 116 0.022
defecation GO:0030421 1 0.021
response to peptide GO:1901652 292 0.021
regulation of cell proliferation GO:0042127 359 0.021
regulation of molecular function GO:0065009 398 0.021
positive regulation of secretion by cell GO:1903532 128 0.021
membrane organization GO:0061024 94 0.021
organic substance catabolic process GO:1901575 316 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
regulation of body fluid levels GO:0050878 90 0.021
secretion GO:0046903 307 0.021
metal ion transport GO:0030001 289 0.020
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.020
response to decreased oxygen levels GO:0036293 237 0.020
cytoskeleton organization GO:0007010 111 0.020
vesicle mediated transport GO:0016192 181 0.020
negative regulation of protein metabolic process GO:0051248 114 0.020
ovulation cycle process GO:0022602 50 0.020
single organism catabolic process GO:0044712 283 0.020
cellular response to insulin stimulus GO:0032869 81 0.019
cation homeostasis GO:0055080 195 0.019
cellular amine metabolic process GO:0044106 38 0.019
synaptic vesicle priming GO:0016082 4 0.019
regulation of dendrite development GO:0050773 59 0.019
protein transport GO:0015031 132 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
establishment of synaptic vesicle localization GO:0097480 23 0.019
vasculature development GO:0001944 70 0.019
response to insulin GO:0032868 133 0.019
organophosphate metabolic process GO:0019637 370 0.019
spermatogenesis GO:0007283 99 0.019
catabolic process GO:0009056 351 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
regulation of hormone levels GO:0010817 187 0.018
signal release GO:0023061 145 0.018
male gamete generation GO:0048232 99 0.018
regulation of cell migration GO:0030334 128 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
regulation of axonogenesis GO:0050770 37 0.018
muscle structure development GO:0061061 87 0.018
positive regulation of synaptic vesicle recycling GO:1903423 1 0.018
cell type specific apoptotic process GO:0097285 134 0.018
homeostatic process GO:0042592 331 0.018
tube development GO:0035295 89 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
negative regulation of rna biosynthetic process GO:1902679 118 0.018
regulation of membrane potential GO:0042391 110 0.018
transmission of nerve impulse GO:0019226 42 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
proteolysis GO:0006508 175 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.018
protein heterooligomerization GO:0051291 89 0.017
cellular response to peptide hormone stimulus GO:0071375 120 0.017
cellular ketone metabolic process GO:0042180 51 0.017
salivary gland development GO:0007431 3 0.017
ensheathment of neurons GO:0007272 40 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
pteridine containing compound metabolic process GO:0042558 14 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
negative regulation of cell communication GO:0010648 158 0.017
chemical homeostasis GO:0048878 292 0.017
response to vitamin GO:0033273 131 0.017
regulation of secretion by cell GO:1903530 208 0.017
locomotor rhythm GO:0045475 1 0.017
organ regeneration GO:0031100 101 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
neuron apoptotic process GO:0051402 88 0.016
negative regulation of transport GO:0051051 136 0.016
embryonic axis specification GO:0000578 1 0.016
regulation of phosphorylation GO:0042325 248 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
anion transport GO:0006820 178 0.016
embryo development GO:0009790 49 0.016
chromosome segregation GO:0007059 2 0.016
forebrain development GO:0030900 98 0.016
neuronal action potential GO:0019228 35 0.016
protein phosphorylation GO:0006468 345 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.016
sensory perception GO:0007600 101 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
single organism biosynthetic process GO:0044711 342 0.016
response to inorganic substance GO:0010035 377 0.016
positive regulation of cell migration GO:0030335 96 0.015
regulation of transferase activity GO:0051338 123 0.015
regulation of catalytic activity GO:0050790 304 0.015
regulation of cellular component movement GO:0051270 150 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
muscle cell proliferation GO:0033002 84 0.015
response to glucose GO:0009749 136 0.015
regulation of developmental growth GO:0048638 45 0.015
cellular lipid metabolic process GO:0044255 208 0.015
morphogenesis of an epithelium GO:0002009 20 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
organic acid metabolic process GO:0006082 292 0.014
cellular response to oxygen containing compound GO:1901701 386 0.014
regulation of catabolic process GO:0009894 113 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
regulation of hormone secretion GO:0046883 106 0.014
regulation of cell motility GO:2000145 131 0.014
reproductive structure development GO:0048608 128 0.014
oxoacid metabolic process GO:0043436 290 0.014
negative regulation of molecular function GO:0044092 133 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
cognition GO:0050890 92 0.014
regulation of neuron differentiation GO:0045664 208 0.014
organic hydroxy compound transport GO:0015850 77 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
regulation of metal ion transport GO:0010959 118 0.014
neuronal ion channel clustering GO:0045161 3 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
purine containing compound catabolic process GO:0072523 138 0.014
positive regulation of apoptotic process GO:0043065 154 0.013
single organism cellular localization GO:1902580 102 0.013
regulation of blood circulation GO:1903522 110 0.013
positive regulation of hormone secretion GO:0046887 65 0.013
actin cytoskeleton organization GO:0030036 73 0.013
behavioral response to ethanol GO:0048149 1 0.013
amide biosynthetic process GO:0043604 10 0.013
hormone secretion GO:0046879 115 0.013
vesicle localization GO:0051648 33 0.013
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.013
amine metabolic process GO:0009308 38 0.013
regulation of homeostatic process GO:0032844 101 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
muscle organ development GO:0007517 50 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
protein oligomerization GO:0051259 191 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
hair cell differentiation GO:0035315 2 0.013
dna replication GO:0006260 37 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.013
developmental maturation GO:0021700 25 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 8 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
heart morphogenesis GO:0003007 3 0.013
maintenance of location GO:0051235 17 0.013
cell cycle checkpoint GO:0000075 2 0.013
cytoplasmic transport GO:0016482 115 0.013
lipid modification GO:0030258 52 0.012
cellular response to oxidative stress GO:0034599 76 0.012
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of signaling GO:0023056 270 0.012
sodium ion transport GO:0006814 82 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
cellular homeostasis GO:0019725 252 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
amide transport GO:0042886 105 0.012
intracellular protein transport GO:0006886 79 0.012
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.012
response to temperature stimulus GO:0009266 94 0.012
sex differentiation GO:0007548 113 0.012
response to electrical stimulus GO:0051602 56 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
cellular protein complex assembly GO:0043623 44 0.012
rho protein signal transduction GO:0007266 11 0.012
regulation of respiratory system process GO:0044065 1 0.012
negative regulation of muscle cell apoptotic process GO:0010656 21 0.012
response to fatty acid GO:0070542 65 0.012
ion homeostasis GO:0050801 212 0.011
peptide hormone secretion GO:0030072 84 0.011
single organism membrane organization GO:0044802 74 0.011
response to interleukin 15 GO:0070672 4 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.011
regulation of dna metabolic process GO:0051052 60 0.011
dendritic spine development GO:0060996 20 0.011
blood circulation GO:0008015 183 0.011
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.011
response to nicotine GO:0035094 51 0.011
response to hexose GO:0009746 144 0.011
insulin secretion GO:0030073 69 0.011
cellular response to oxygen levels GO:0071453 60 0.011
cell growth GO:0016049 104 0.011
signal transduction involved in regulation of gene expression GO:0023019 4 0.011
response to corticosteroid GO:0031960 235 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
cell cycle GO:0007049 101 0.011
gliogenesis GO:0042063 93 0.011
regulation of anatomical structure size GO:0090066 135 0.011
gastrulation GO:0007369 2 0.011
metal ion homeostasis GO:0055065 186 0.011
nitrogen compound transport GO:0071705 229 0.011
positive regulation of homeostatic process GO:0032846 49 0.011
rna localization GO:0006403 4 0.011
development of primary female sexual characteristics GO:0046545 56 0.011
muscle cell differentiation GO:0042692 52 0.011
cellular chemical homeostasis GO:0055082 247 0.011
steroid metabolic process GO:0008202 73 0.011
lung development GO:0030324 43 0.011
regulation of immune system process GO:0002682 123 0.011
regulation of secretion GO:0051046 224 0.011
heart process GO:0003015 57 0.011
developmental growth involved in morphogenesis GO:0060560 33 0.011
regulation of transporter activity GO:0032409 50 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
circadian regulation of gene expression GO:0032922 3 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
regulation of ion transmembrane transporter activity GO:0032412 48 0.011
response to estradiol GO:0032355 164 0.011
peptidyl amino acid modification GO:0018193 126 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
positive regulation of locomotion GO:0040017 102 0.011
regulation of bmp signaling pathway GO:0030510 2 0.011
response to carbohydrate GO:0009743 183 0.011
negative regulation of cell death GO:0060548 229 0.011
sensory organ development GO:0007423 74 0.010
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
asymmetric protein localization GO:0008105 2 0.010
negative regulation of cellular component organization GO:0051129 83 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
platelet aggregation GO:0070527 4 0.010
carbohydrate homeostasis GO:0033500 75 0.010
salivary gland morphogenesis GO:0007435 1 0.010
negative regulation of signaling GO:0023057 157 0.010
growth GO:0040007 165 0.010
membrane depolarization GO:0051899 32 0.010

Sp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
gastrointestinal system cancer DOID:3119 0 0.015
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
central nervous system disease DOID:331 0 0.011