Rattus norvegicus

33 known processes

Spr

sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

Spr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.077
single organism biosynthetic process GO:0044711 342 0.067
organic substance catabolic process GO:1901575 316 0.067
response to inorganic substance GO:0010035 377 0.066
organic acid metabolic process GO:0006082 292 0.065
neuron differentiation GO:0030182 368 0.060
cellular component assembly GO:0022607 360 0.054
carboxylic acid metabolic process GO:0019752 289 0.053
catabolic process GO:0009056 351 0.040
response to extracellular stimulus GO:0009991 380 0.039
cellular component biogenesis GO:0044085 368 0.038
response to decreased oxygen levels GO:0036293 237 0.038
protein phosphorylation GO:0006468 345 0.037
carboxylic acid biosynthetic process GO:0046394 83 0.036
single organism catabolic process GO:0044712 283 0.036
protein complex subunit organization GO:0071822 302 0.036
neuron development GO:0048666 286 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
response to nutrient levels GO:0031667 370 0.034
organophosphate metabolic process GO:0019637 370 0.034
cellular amino acid metabolic process GO:0006520 107 0.033
ribose phosphate metabolic process GO:0019693 235 0.032
response to metal ion GO:0010038 253 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
regulation of phosphorus metabolic process GO:0051174 349 0.031
cell projection organization GO:0030030 302 0.031
response to peptide hormone GO:0043434 278 0.031
nucleotide metabolic process GO:0009117 279 0.030
cellular ketone metabolic process GO:0042180 51 0.030
macromolecular complex assembly GO:0065003 273 0.030
cellular catabolic process GO:0044248 295 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
regulation of cell differentiation GO:0045595 320 0.028
purine containing compound metabolic process GO:0072521 253 0.028
programmed cell death GO:0012501 392 0.028
regulation of cellular component organization GO:0051128 368 0.028
neuron projection development GO:0031175 273 0.027
monocarboxylic acid metabolic process GO:0032787 152 0.027
response to hypoxia GO:0001666 231 0.027
regulation of molecular function GO:0065009 398 0.027
regulation of cell development GO:0060284 263 0.027
positive regulation of response to stimulus GO:0048584 285 0.026
lipid metabolic process GO:0006629 283 0.026
response to glucocorticoid GO:0051384 223 0.026
positive regulation of cellular component organization GO:0051130 200 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
organic acid biosynthetic process GO:0016053 83 0.025
response to nutrient GO:0007584 248 0.025
response to corticosteroid GO:0031960 235 0.025
chemical homeostasis GO:0048878 292 0.025
response to carbohydrate GO:0009743 183 0.025
carbohydrate derivative metabolic process GO:1901135 346 0.024
protein complex assembly GO:0006461 263 0.024
homeostatic process GO:0042592 331 0.024
cellular amine metabolic process GO:0044106 38 0.024
regulation of protein metabolic process GO:0051246 289 0.024
reproductive process GO:0022414 372 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
transmembrane transport GO:0055085 412 0.023
response to peptide GO:1901652 292 0.023
ion homeostasis GO:0050801 212 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
response to wounding GO:0009611 254 0.022
small molecule biosynthetic process GO:0044283 124 0.022
regulation of neurogenesis GO:0050767 247 0.022
ion transmembrane transport GO:0034220 365 0.022
head development GO:0060322 247 0.021
amine metabolic process GO:0009308 38 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
protein oligomerization GO:0051259 191 0.021
negative regulation of metabolic process GO:0009892 331 0.021
protein complex biogenesis GO:0070271 263 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
regulation of neuron differentiation GO:0045664 208 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
ribonucleotide metabolic process GO:0009259 231 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
nucleoside metabolic process GO:0009116 179 0.020
lipid biosynthetic process GO:0008610 128 0.020
response to oxygen levels GO:0070482 265 0.020
oxidation reduction process GO:0055114 304 0.020
cellular chemical homeostasis GO:0055082 247 0.020
multi organism reproductive process GO:0044703 262 0.020
regulation of neuron projection development GO:0010975 161 0.020
cellular response to stress GO:0033554 269 0.020
intracellular signal transduction GO:0035556 314 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
localization of cell GO:0051674 202 0.019
negative regulation of cell proliferation GO:0008285 119 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
response to monosaccharide GO:0034284 159 0.019
cation transport GO:0006812 382 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
cellular component movement GO:0006928 248 0.019
cellular homeostasis GO:0019725 252 0.019
response to transition metal nanoparticle GO:1990267 122 0.018
regulation of catalytic activity GO:0050790 304 0.018
regulation of cell proliferation GO:0042127 359 0.018
positive regulation of developmental process GO:0051094 283 0.018
central nervous system development GO:0007417 311 0.018
metal ion transport GO:0030001 289 0.018
inflammatory response GO:0006954 150 0.018
cation transmembrane transport GO:0098655 263 0.018
reproduction GO:0000003 245 0.018
blood circulation GO:0008015 183 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
regulation of nervous system development GO:0051960 264 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
wound healing GO:0042060 122 0.017
regulation of phosphorylation GO:0042325 248 0.017
cellular component morphogenesis GO:0032989 155 0.017
carbohydrate metabolic process GO:0005975 130 0.017
response to estrogen GO:0043627 232 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
multicellular organism reproduction GO:0032504 233 0.016
response to toxic substance GO:0009636 133 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
response to growth factor GO:0070848 189 0.016
circulatory system process GO:0003013 183 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.016
single organism reproductive process GO:0044702 297 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
chromosome segregation GO:0007059 2 0.016
negative regulation of molecular function GO:0044092 133 0.016
organophosphate catabolic process GO:0046434 148 0.016
macromolecule localization GO:0033036 252 0.016
brain development GO:0007420 247 0.016
single organism organelle organization GO:1902589 180 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
small gtpase mediated signal transduction GO:0007264 36 0.015
regulation of cell projection organization GO:0031344 175 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
cardiac chamber development GO:0003205 1 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
alpha amino acid metabolic process GO:1901605 71 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
cation homeostasis GO:0055080 195 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
regulation of hormone levels GO:0010817 187 0.015
cellular cation homeostasis GO:0030003 180 0.015
locomotion GO:0040011 237 0.014
nitrogen compound transport GO:0071705 229 0.014
response to cytokine GO:0034097 215 0.014
organelle organization GO:0006996 266 0.014
heterocycle catabolic process GO:0046700 167 0.014
heart morphogenesis GO:0003007 3 0.014
cellular modified amino acid metabolic process GO:0006575 61 0.014
fatty acid metabolic process GO:0006631 99 0.014
negative regulation of cellular metabolic process GO:0031324 281 0.014
regulation of body fluid levels GO:0050878 90 0.014
response to glucose GO:0009749 136 0.014
response to oxidative stress GO:0006979 186 0.014
hexose metabolic process GO:0019318 58 0.014
developmental process involved in reproduction GO:0003006 159 0.014
sex differentiation GO:0007548 113 0.014
small molecule catabolic process GO:0044282 59 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
neuron projection morphogenesis GO:0048812 122 0.014
metal ion homeostasis GO:0055065 186 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
regulation of signal transduction GO:0009966 318 0.014
reproductive system development GO:0061458 128 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
cell growth GO:0016049 104 0.013
cofactor metabolic process GO:0051186 95 0.013
cellular response to external stimulus GO:0071496 118 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
regulation of system process GO:0044057 208 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
reproductive structure development GO:0048608 128 0.013
response to hexose GO:0009746 144 0.013
positive regulation of cell development GO:0010720 176 0.013
response to acid chemical GO:0001101 222 0.013
proteolysis GO:0006508 175 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
neurological system process GO:0050877 219 0.013
anterior posterior pattern specification GO:0009952 1 0.013
response to insulin GO:0032868 133 0.013
cellular lipid metabolic process GO:0044255 208 0.013
negative regulation of innate immune response GO:0045824 4 0.013
aromatic compound catabolic process GO:0019439 168 0.013
gonad development GO:0008406 104 0.013
multicellular organismal signaling GO:0035637 44 0.013
development of primary sexual characteristics GO:0045137 107 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
rna biosynthetic process GO:0032774 380 0.013
anion transport GO:0006820 178 0.013
positive regulation of signaling GO:0023056 270 0.013
dephosphorylation GO:0016311 98 0.012
transmission of nerve impulse GO:0019226 42 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
carboxylic acid catabolic process GO:0046395 49 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
positive regulation of molecular function GO:0044093 230 0.012
response to ketone GO:1901654 182 0.012
synaptic transmission GO:0007268 235 0.012
sexual reproduction GO:0019953 148 0.012
aging GO:0007568 241 0.012
regulation of apoptotic process GO:0042981 335 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
gamete generation GO:0007276 124 0.012
neuronal action potential GO:0019228 35 0.012
regulation of protein modification process GO:0031399 194 0.012
cardiac ventricle development GO:0003231 1 0.012
organic acid transport GO:0015849 116 0.012
response to alkaloid GO:0043279 132 0.012
response to organophosphorus GO:0046683 102 0.012
response to biotic stimulus GO:0009607 226 0.012
carboxylic acid transport GO:0046942 115 0.012
regulation of ion transport GO:0043269 245 0.012
immune system process GO:0002376 204 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
ras protein signal transduction GO:0007265 29 0.012
centrosome organization GO:0051297 1 0.012
axis specification GO:0009798 4 0.011
positive regulation of cell communication GO:0010647 271 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
cell part morphogenesis GO:0032990 123 0.011
regulation of cellular localization GO:0060341 263 0.011
cellular ion homeostasis GO:0006873 184 0.011
monosaccharide metabolic process GO:0005996 61 0.011
apoptotic process GO:0006915 381 0.011
cell motility GO:0048870 202 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
cardiovascular system development GO:0072358 134 0.011
response to bacterium GO:0009617 200 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
regulation of membrane potential GO:0042391 110 0.011
response to vitamin GO:0033273 131 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
action potential GO:0001508 54 0.011
response to external biotic stimulus GO:0043207 221 0.011
regulation of muscle system process GO:0090257 79 0.011
defense response GO:0006952 194 0.011
intracellular transport GO:0046907 185 0.011
response to purine containing compound GO:0014074 126 0.011
secretion GO:0046903 307 0.011
actin filament based process GO:0030029 86 0.011
regulation of response to stress GO:0080134 126 0.011
regulation of rna metabolic process GO:0051252 391 0.011
response to estradiol GO:0032355 164 0.010
single organism carbohydrate metabolic process GO:0044723 118 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
purine containing compound catabolic process GO:0072523 138 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
positive regulation of nervous system development GO:0051962 178 0.010
embryonic pattern specification GO:0009880 1 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
growth GO:0040007 165 0.010
positive regulation of gene expression GO:0010628 244 0.010
anion transmembrane transport GO:0098656 77 0.010
male gamete generation GO:0048232 99 0.010
response to molecule of bacterial origin GO:0002237 194 0.010

Spr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.012
musculoskeletal system disease DOID:17 0 0.012