Rattus norvegicus

0 known processes

Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

(Aliases: MGC72653,Fn14)

Tnfrsf12a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tissue development GO:0009888 252 0.288
regulation of nucleic acid templated transcription GO:1903506 380 0.219
programmed cell death GO:0012501 392 0.216
negative regulation of cell death GO:0060548 229 0.216
regulation of apoptotic process GO:0042981 335 0.210
nucleic acid templated transcription GO:0097659 379 0.199
cellular response to stress GO:0033554 269 0.193
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.150
positive regulation of cell proliferation GO:0008284 249 0.145
neuron differentiation GO:0030182 368 0.142
response to inorganic substance GO:0010035 377 0.139
response to oxidative stress GO:0006979 186 0.138
response to decreased oxygen levels GO:0036293 237 0.136
apoptotic process GO:0006915 381 0.135
response to hypoxia GO:0001666 231 0.128
head development GO:0060322 247 0.126
transcription from rna polymerase ii promoter GO:0006366 252 0.126
central nervous system development GO:0007417 311 0.121
negative regulation of programmed cell death GO:0043069 183 0.112
transmembrane transport GO:0055085 412 0.112
regulation of programmed cell death GO:0043067 341 0.103
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.101
response to hydrogen peroxide GO:0042542 89 0.101
regulation of rna metabolic process GO:0051252 391 0.097
response to oxygen levels GO:0070482 265 0.096
positive regulation of biosynthetic process GO:0009891 319 0.095
regulation of transcription dna templated GO:0006355 374 0.094
response to corticosteroid GO:0031960 235 0.093
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.090
cellular response to endogenous stimulus GO:0071495 377 0.087
negative regulation of apoptotic process GO:0043066 181 0.085
epithelium development GO:0060429 96 0.084
positive regulation of rna biosynthetic process GO:1902680 197 0.083
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.081
regulation of neuron apoptotic process GO:0043523 83 0.078
ion transmembrane transport GO:0034220 365 0.076
regulation of catalytic activity GO:0050790 304 0.074
cell matrix adhesion GO:0007160 19 0.074
cellular response to nitrogen compound GO:1901699 210 0.071
cellular response to oxygen containing compound GO:1901701 386 0.070
cell type specific apoptotic process GO:0097285 134 0.068
regulation of rna biosynthetic process GO:2001141 381 0.068
regulation of cell proliferation GO:0042127 359 0.067
positive regulation of signaling GO:0023056 270 0.065
response to wounding GO:0009611 254 0.065
cellular response to oxidative stress GO:0034599 76 0.065
response to estrogen GO:0043627 232 0.064
response to extracellular stimulus GO:0009991 380 0.064
positive regulation of cellular biosynthetic process GO:0031328 295 0.063
response to other organism GO:0051707 220 0.063
response to nutrient GO:0007584 248 0.063
regulation of cell differentiation GO:0045595 320 0.061
positive regulation of rna metabolic process GO:0051254 203 0.061
response to reactive oxygen species GO:0000302 120 0.060
positive regulation of nucleic acid templated transcription GO:1903508 197 0.060
response to growth factor GO:0070848 189 0.058
regulation of signal transduction GO:0009966 318 0.057
neuron development GO:0048666 286 0.057
intracellular signal transduction GO:0035556 314 0.057
reproductive process GO:0022414 372 0.056
gland development GO:0048732 155 0.056
response to peptide GO:1901652 292 0.054
single organism reproductive process GO:0044702 297 0.053
regeneration GO:0031099 163 0.053
response to tumor cell GO:0002347 4 0.052
response to nutrient levels GO:0031667 370 0.052
multicellular organism reproduction GO:0032504 233 0.051
response to mechanical stimulus GO:0009612 134 0.050
positive regulation of intracellular signal transduction GO:1902533 138 0.049
protein phosphorylation GO:0006468 345 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.046
signal transduction by phosphorylation GO:0023014 144 0.046
negative regulation of cell proliferation GO:0008285 119 0.046
rna metabolic process GO:0016070 406 0.046
positive regulation of cell communication GO:0010647 271 0.045
cellular response to steroid hormone stimulus GO:0071383 93 0.045
rna biosynthetic process GO:0032774 380 0.045
anatomical structure morphogenesis GO:0009653 298 0.044
single organism organelle organization GO:1902589 180 0.043
response to metal ion GO:0010038 253 0.041
positive regulation of molecular function GO:0044093 230 0.041
immune response to tumor cell GO:0002418 3 0.041
positive regulation of phosphate metabolic process GO:0045937 262 0.041
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.040
negative regulation of response to stimulus GO:0048585 155 0.040
cellular response to organic cyclic compound GO:0071407 202 0.039
positive regulation of phosphorylation GO:0042327 177 0.039
positive regulation of response to stimulus GO:0048584 285 0.039
carboxylic acid transport GO:0046942 115 0.039
brain development GO:0007420 247 0.038
macromolecular complex subunit organization GO:0043933 339 0.038
negative regulation of molecular function GO:0044092 133 0.037
negative regulation of biosynthetic process GO:0009890 168 0.037
neuron death GO:0070997 127 0.037
positive regulation of developmental process GO:0051094 283 0.037
response to glucocorticoid GO:0051384 223 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.035
cellular response to organonitrogen compound GO:0071417 197 0.035
cellular catabolic process GO:0044248 295 0.035
circulatory system process GO:0003013 183 0.034
cation transport GO:0006812 382 0.034
positive regulation of transcription dna templated GO:0045893 197 0.034
single organism catabolic process GO:0044712 283 0.034
protein complex assembly GO:0006461 263 0.034
cell migration GO:0016477 197 0.034
cellular response to peptide GO:1901653 133 0.034
defense response GO:0006952 194 0.033
single organism carbohydrate metabolic process GO:0044723 118 0.033
cell cycle GO:0007049 101 0.033
positive regulation of gene expression GO:0010628 244 0.033
regulation of molecular function GO:0065009 398 0.033
reproductive structure development GO:0048608 128 0.032
transcription dna templated GO:0006351 377 0.032
wound healing GO:0042060 122 0.032
organic acid metabolic process GO:0006082 292 0.032
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.031
biological adhesion GO:0022610 110 0.031
positive regulation of protein modification process GO:0031401 142 0.031
cellular ketone metabolic process GO:0042180 51 0.031
regulation of smooth muscle cell proliferation GO:0048660 75 0.031
heart contraction GO:0060047 57 0.031
regulation of defense response GO:0031347 68 0.031
negative regulation of cellular metabolic process GO:0031324 281 0.031
regulation of response to stress GO:0080134 126 0.031
cellular response to external stimulus GO:0071496 118 0.030
cellular response to oxygen levels GO:0071453 60 0.030
growth GO:0040007 165 0.030
negative regulation of gene expression GO:0010629 199 0.029
positive regulation of apoptotic process GO:0043065 154 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.029
immune system process GO:0002376 204 0.029
negative regulation of metabolic process GO:0009892 331 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
actin cytoskeleton organization GO:0030036 73 0.028
response to acid chemical GO:0001101 222 0.028
gliogenesis GO:0042063 93 0.027
muscle cell proliferation GO:0033002 84 0.027
response to external biotic stimulus GO:0043207 221 0.027
cellular response to growth factor stimulus GO:0071363 162 0.027
positive regulation of fibroblast proliferation GO:0048146 15 0.026
protein heterooligomerization GO:0051291 89 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.026
response to interleukin 1 GO:0070555 55 0.026
regulation of protein metabolic process GO:0051246 289 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
positive regulation of cell death GO:0010942 184 0.025
regulation of ion transport GO:0043269 245 0.025
reproduction GO:0000003 245 0.025
oxoacid metabolic process GO:0043436 290 0.025
negative regulation of macromolecule metabolic process GO:0010605 260 0.025
multi multicellular organism process GO:0044706 138 0.025
nucleotide metabolic process GO:0009117 279 0.025
nitrogen compound transport GO:0071705 229 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
maternal process involved in female pregnancy GO:0060135 38 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
positive regulation of signal transduction GO:0009967 175 0.025
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.024
gastrulation GO:0007369 2 0.024
reproductive system development GO:0061458 128 0.024
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.024
single organism biosynthetic process GO:0044711 342 0.024
response to transition metal nanoparticle GO:1990267 122 0.024
organelle organization GO:0006996 266 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
muscle tissue development GO:0060537 58 0.023
aging GO:0007568 241 0.023
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.023
cellular component assembly GO:0022607 360 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
positive regulation of catalytic activity GO:0043085 184 0.023
cellular amine metabolic process GO:0044106 38 0.023
actin filament based process GO:0030029 86 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
organic anion transport GO:0015711 132 0.022
neuron apoptotic process GO:0051402 88 0.022
response to ketone GO:1901654 182 0.022
positive regulation of immune system process GO:0002684 90 0.022
cellular response to reactive oxygen species GO:0034614 55 0.022
smooth muscle cell proliferation GO:0048659 77 0.022
striated muscle tissue development GO:0014706 58 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.021
regulation of protein modification process GO:0031399 194 0.021
macromolecular complex assembly GO:0065003 273 0.021
chemical homeostasis GO:0048878 292 0.021
response to peptide hormone GO:0043434 278 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
neuron projection development GO:0031175 273 0.021
regulation of cellular component organization GO:0051128 368 0.021
cardiovascular system development GO:0072358 134 0.021
cation transmembrane transport GO:0098655 263 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
amine metabolic process GO:0009308 38 0.020
cell cell signaling GO:0007267 335 0.020
anion transport GO:0006820 178 0.020
blood circulation GO:0008015 183 0.020
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
catabolic process GO:0009056 351 0.019
multi organism reproductive process GO:0044703 262 0.019
developmental growth GO:0048589 100 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
regulation of cell cycle GO:0051726 73 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
response to vitamin GO:0033273 131 0.019
response to hexose GO:0009746 144 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
cell cycle process GO:0022402 57 0.019
protein oligomerization GO:0051259 191 0.019
mesoderm development GO:0007498 2 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
cellular response to corticosteroid stimulus GO:0071384 69 0.019
protein complex biogenesis GO:0070271 263 0.018
response to purine containing compound GO:0014074 126 0.018
protein complex subunit organization GO:0071822 302 0.018
response to organophosphorus GO:0046683 102 0.018
positive regulation of nervous system development GO:0051962 178 0.018
response to toxic substance GO:0009636 133 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
circulatory system development GO:0072359 134 0.018
cold acclimation GO:0009631 1 0.018
positive regulation of cell development GO:0010720 176 0.018
forebrain development GO:0030900 98 0.018
organ regeneration GO:0031100 101 0.018
regulation of nervous system development GO:0051960 264 0.018
single organism cellular localization GO:1902580 102 0.018
positive regulation of neuron death GO:1901216 43 0.018
ribose phosphate metabolic process GO:0019693 235 0.017
carbohydrate metabolic process GO:0005975 130 0.017
cell adhesion GO:0007155 110 0.017
regulation of carbohydrate catabolic process GO:0043470 14 0.017
regulation of metal ion transport GO:0010959 118 0.017
regulation of neurogenesis GO:0050767 247 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
regulation of ion transmembrane transport GO:0034765 121 0.017
negative regulation of cell communication GO:0010648 158 0.017
gonad development GO:0008406 104 0.017
cellular response to extracellular stimulus GO:0031668 73 0.017
hepaticobiliary system development GO:0061008 90 0.017
cellular component biogenesis GO:0044085 368 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
regulation of cellular localization GO:0060341 263 0.017
reactive oxygen species metabolic process GO:0072593 37 0.017
regulation of cell development GO:0060284 263 0.017
divalent metal ion transport GO:0070838 132 0.017
negative regulation of transport GO:0051051 136 0.017
intracellular transport GO:0046907 185 0.017
developmental process involved in reproduction GO:0003006 159 0.016
liver development GO:0001889 90 0.016
homeostatic process GO:0042592 331 0.016
muscle system process GO:0003012 115 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
heart process GO:0003015 57 0.016
plasminogen activation GO:0031639 2 0.016
dna metabolic process GO:0006259 96 0.016
glucose homeostasis GO:0042593 75 0.016
cofactor metabolic process GO:0051186 95 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of transport GO:0051050 245 0.016
regulation of neuron death GO:1901214 115 0.016
regulation of kinase activity GO:0043549 117 0.016
development of primary sexual characteristics GO:0045137 107 0.016
lipid metabolic process GO:0006629 283 0.016
hemostasis GO:0007599 26 0.016
cell substrate adhesion GO:0031589 29 0.016
keratinocyte migration GO:0051546 2 0.016
regulation of endothelial cell apoptotic process GO:2000351 3 0.016
heart morphogenesis GO:0003007 3 0.016
small molecule biosynthetic process GO:0044283 124 0.015
cellular homeostasis GO:0019725 252 0.015
cellular response to hypoxia GO:0071456 51 0.015
ras protein signal transduction GO:0007265 29 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
female gonad development GO:0008585 53 0.015
muscle structure development GO:0061061 87 0.015
regulation of immune system process GO:0002682 123 0.015
localization of cell GO:0051674 202 0.015
monosaccharide metabolic process GO:0005996 61 0.015
coagulation GO:0050817 28 0.015
response to high density lipoprotein particle GO:0055099 2 0.015
cellular response to lipid GO:0071396 201 0.015
organophosphate metabolic process GO:0019637 370 0.015
response to starvation GO:0042594 59 0.015
regulation of cell projection organization GO:0031344 175 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
regulation of phosphorylation GO:0042325 248 0.015
muscle organ development GO:0007517 50 0.015
ossification GO:0001503 70 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
locomotion GO:0040011 237 0.015
cytoskeleton organization GO:0007010 111 0.014
response to amino acid GO:0043200 75 0.014
female pregnancy GO:0007565 122 0.014
response to cycloheximide GO:0046898 6 0.014
synapse assembly GO:0007416 29 0.014
positive regulation of neuron apoptotic process GO:0043525 33 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
leukocyte mediated immunity GO:0002443 28 0.014
oxidation reduction process GO:0055114 304 0.014
organic substance catabolic process GO:1901575 316 0.014
skeletal muscle organ development GO:0060538 33 0.014
dendrite development GO:0016358 72 0.014
programmed necrotic cell death GO:0097300 2 0.014
response to bacterium GO:0009617 200 0.014
angiogenesis GO:0001525 53 0.014
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.014
cytoplasmic transport GO:0016482 115 0.013
epithelial cell differentiation GO:0030855 71 0.013
single organism intracellular transport GO:1902582 166 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
response to estradiol GO:0032355 164 0.013
cellular response to hydrogen peroxide GO:0070301 42 0.013
hexose metabolic process GO:0019318 58 0.013
anterior posterior pattern specification GO:0009952 1 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
positive regulation of cell migration GO:0030335 96 0.013
positive regulation of response to wounding GO:1903036 34 0.013
positive regulation of transferase activity GO:0051347 81 0.013
response to monosaccharide GO:0034284 159 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
positive regulation of natural killer cell mediated immunity GO:0002717 2 0.013
regulation of cell motility GO:2000145 131 0.013
mapk cascade GO:0000165 140 0.013
response to ethanol GO:0045471 162 0.013
dephosphorylation GO:0016311 98 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
formation of primary germ layer GO:0001704 1 0.012
skeletal muscle tissue development GO:0007519 31 0.012
muscle cell differentiation GO:0042692 52 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
multicellular organismal signaling GO:0035637 44 0.012
cellular component morphogenesis GO:0032989 155 0.012
gamete generation GO:0007276 124 0.012
purine containing compound metabolic process GO:0072521 253 0.012
cellular response to alcohol GO:0097306 87 0.012
dendrite morphogenesis GO:0048813 43 0.012
secretion by cell GO:0032940 248 0.012
female sex differentiation GO:0046660 59 0.012
negative regulation of signaling GO:0023057 157 0.012
cell growth GO:0016049 104 0.012
development of primary female sexual characteristics GO:0046545 56 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
autophagic cell death GO:0048102 4 0.012
regulation of system process GO:0044057 208 0.012
metal ion transport GO:0030001 289 0.012
response to cgmp GO:0070305 3 0.012
male gamete generation GO:0048232 99 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
cellular response to glucocorticoid stimulus GO:0071385 68 0.012
immune response GO:0006955 104 0.012
regulation of response to external stimulus GO:0032101 106 0.012
regulation of cell adhesion GO:0030155 52 0.012
axis specification GO:0009798 4 0.012
urogenital system development GO:0001655 78 0.012
nucleocytoplasmic transport GO:0006913 48 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
regulation of transmembrane transport GO:0034762 122 0.012
proteolysis GO:0006508 175 0.012
response to biotic stimulus GO:0009607 226 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
regulation of response to wounding GO:1903034 69 0.012
muscle contraction GO:0006936 88 0.012
blood vessel development GO:0001568 69 0.011
sex differentiation GO:0007548 113 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
apoptotic signaling pathway GO:0097190 27 0.011
regulation of intracellular transport GO:0032386 65 0.011
cell part morphogenesis GO:0032990 123 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
cellular response to metal ion GO:0071248 55 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
amino acid transport GO:0006865 70 0.011
cytokine production GO:0001816 61 0.011
negative regulation of developmental process GO:0051093 125 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
regulation of synaptic transmission GO:0050804 141 0.011
wound healing spreading of cells GO:0044319 2 0.011
regulation of hydrolase activity GO:0051336 143 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
regulation of neuron differentiation GO:0045664 208 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
regulation of protein localization GO:0032880 81 0.011
collecting duct development GO:0072044 1 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
endothelial cell apoptotic process GO:0072577 3 0.010
cellular response to inorganic substance GO:0071241 65 0.010
glial cell differentiation GO:0010001 65 0.010
cell projection organization GO:0030030 302 0.010
positive regulation of ion transport GO:0043270 94 0.010
regulation of body fluid levels GO:0050878 90 0.010
positive regulation of t cell mediated immunity GO:0002711 4 0.010
regulation of blood circulation GO:1903522 110 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
negative regulation of osteoblast differentiation GO:0045668 2 0.010
lipid storage GO:0019915 1 0.010
positive regulation of mapk cascade GO:0043410 92 0.010

Tnfrsf12a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038
neuromuscular disease DOID:440 0 0.038
charcot marie tooth disease DOID:10595 0 0.038
neuropathy DOID:870 0 0.038
musculoskeletal system disease DOID:17 0 0.020
myopathy DOID:423 0 0.020
muscular disease DOID:0080000 0 0.020
muscle tissue disease DOID:66 0 0.020
heart disease DOID:114 0 0.019
cardiomyopathy DOID:0050700 0 0.019
dilated cardiomyopathy DOID:12930 0 0.019
intrinsic cardiomyopathy DOID:0060036 0 0.019
cardiovascular system disease DOID:1287 0 0.019
central nervous system disease DOID:331 0 0.018
lipodystrophy DOID:811 0 0.014
skin disease DOID:37 0 0.014
integumentary system disease DOID:16 0 0.014
charcot marie tooth disease type 2 DOID:0050539 0 0.013