Rattus norvegicus

53 known processes

Pde10a

phosphodiesterase 10A

(Aliases: Pde10a3)

Pde10a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.163
cellular response to endogenous stimulus GO:0071495 377 0.159
response to oxygen levels GO:0070482 265 0.153
Rat
cell projection organization GO:0030030 302 0.131
behavior GO:0007610 205 0.125
Rat
apoptotic process GO:0006915 381 0.114
Rat
regulation of signal transduction GO:0009966 318 0.107
Mouse
cell cell signaling GO:0007267 335 0.097
protein phosphorylation GO:0006468 345 0.096
regulation of phosphate metabolic process GO:0019220 349 0.092
Rat
regulation of multicellular organismal development GO:2000026 376 0.091
neuron projection morphogenesis GO:0048812 122 0.082
anatomical structure morphogenesis GO:0009653 298 0.082
response to inorganic substance GO:0010035 377 0.080
positive regulation of cell proliferation GO:0008284 249 0.079
regulation of rna metabolic process GO:0051252 391 0.079
cation transport GO:0006812 382 0.077
neuron differentiation GO:0030182 368 0.071
rna biosynthetic process GO:0032774 380 0.070
neuron development GO:0048666 286 0.067
metal ion transport GO:0030001 289 0.066
cellular component movement GO:0006928 248 0.065
regulation of catalytic activity GO:0050790 304 0.064
neuron projection development GO:0031175 273 0.064
protein complex subunit organization GO:0071822 302 0.063
regulation of transcription dna templated GO:0006355 374 0.061
oxoacid metabolic process GO:0043436 290 0.061
response to hypoxia GO:0001666 231 0.061
Rat
transcription dna templated GO:0006351 377 0.058
cell motility GO:0048870 202 0.058
growth GO:0040007 165 0.056
regulation of programmed cell death GO:0043067 341 0.056
Rat
monovalent inorganic cation transport GO:0015672 172 0.056
regulation of rna biosynthetic process GO:2001141 381 0.055
regulation of phosphorylation GO:0042325 248 0.055
synaptic transmission GO:0007268 235 0.053
purine nucleoside metabolic process GO:0042278 169 0.052
positive regulation of nervous system development GO:0051962 178 0.051
regulation of nervous system development GO:0051960 264 0.051
nucleic acid templated transcription GO:0097659 379 0.051
positive regulation of multicellular organismal process GO:0051240 387 0.051
Rat
neurological system process GO:0050877 219 0.050
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.050
regulation of cell development GO:0060284 263 0.049
positive regulation of phosphorus metabolic process GO:0010562 262 0.049
cellular component biogenesis GO:0044085 368 0.049
response to bacterium GO:0009617 200 0.048
Rat
synapse organization GO:0050808 46 0.048
positive regulation of cell development GO:0010720 176 0.047
purine ribonucleotide metabolic process GO:0009150 227 0.047
organophosphate metabolic process GO:0019637 370 0.047
nucleoside phosphate metabolic process GO:0006753 283 0.046
regulation of protein metabolic process GO:0051246 289 0.046
cellular amino acid metabolic process GO:0006520 107 0.046
positive regulation of cell differentiation GO:0045597 217 0.045
catabolic process GO:0009056 351 0.045
regulation of protein modification process GO:0031399 194 0.045
cellular component morphogenesis GO:0032989 155 0.045
negative regulation of cell death GO:0060548 229 0.044
reproduction GO:0000003 245 0.043
macromolecular complex subunit organization GO:0043933 339 0.043
regulation of neurogenesis GO:0050767 247 0.043
response to peptide GO:1901652 292 0.043
positive regulation of neurogenesis GO:0050769 165 0.042
eye morphogenesis GO:0048592 4 0.042
organic acid metabolic process GO:0006082 292 0.041
protein complex biogenesis GO:0070271 263 0.041
negative regulation of signaling GO:0023057 157 0.041
tissue development GO:0009888 252 0.041
Rat
multi organism reproductive process GO:0044703 262 0.040
regulation of anatomical structure morphogenesis GO:0022603 141 0.039
purine ribonucleoside metabolic process GO:0046128 168 0.039
protein complex assembly GO:0006461 263 0.039
regulation of cellular protein metabolic process GO:0032268 267 0.038
single organism catabolic process GO:0044712 283 0.038
organic substance catabolic process GO:1901575 316 0.038
organonitrogen compound biosynthetic process GO:1901566 167 0.038
Rat
brain development GO:0007420 247 0.038
transmembrane transport GO:0055085 412 0.038
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.038
cellular catabolic process GO:0044248 295 0.038
heterocycle catabolic process GO:0046700 167 0.037
carbohydrate derivative catabolic process GO:1901136 147 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
Rat
regulation of protein phosphorylation GO:0001932 183 0.036
carboxylic acid metabolic process GO:0019752 289 0.036
ribonucleoside catabolic process GO:0042454 126 0.035
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.035
regulation of neuron differentiation GO:0045664 208 0.034
cardiac conduction GO:0061337 2 0.034
positive regulation of developmental process GO:0051094 283 0.034
cellular ketone metabolic process GO:0042180 51 0.033
purine containing compound catabolic process GO:0072523 138 0.033
negative regulation of multicellular organismal process GO:0051241 203 0.033
intracellular signal transduction GO:0035556 314 0.033
Mouse Rat
regulation of cell proliferation GO:0042127 359 0.032
nucleobase containing small molecule metabolic process GO:0055086 316 0.032
rna metabolic process GO:0016070 406 0.032
nucleoside metabolic process GO:0009116 179 0.032
response to extracellular stimulus GO:0009991 380 0.032
macromolecular complex assembly GO:0065003 273 0.032
cell communication involved in cardiac conduction GO:0086065 2 0.032
response to peptide hormone GO:0043434 278 0.032
glycosyl compound metabolic process GO:1901657 182 0.031
ribonucleotide metabolic process GO:0009259 231 0.031
sodium ion transport GO:0006814 82 0.031
regulation of angiogenesis GO:0045765 39 0.031
cellular response to peptide hormone stimulus GO:0071375 120 0.031
regulation of cell differentiation GO:0045595 320 0.031
gtp metabolic process GO:0046039 72 0.031
nucleotide metabolic process GO:0009117 279 0.031
positive regulation of rna metabolic process GO:0051254 203 0.031
ribonucleotide catabolic process GO:0009261 136 0.030
localization of cell GO:0051674 202 0.030
cellular component assembly GO:0022607 360 0.030
positive regulation of signaling GO:0023056 270 0.030
cell morphogenesis involved in differentiation GO:0000904 119 0.030
regulation of dendrite development GO:0050773 59 0.030
cellular response to oxygen containing compound GO:1901701 386 0.030
regulation of apoptotic process GO:0042981 335 0.030
Rat
regulation of neuron projection development GO:0010975 161 0.030
ion transmembrane transport GO:0034220 365 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
regulation of system process GO:0044057 208 0.029
Rat
regulation of transferase activity GO:0051338 123 0.029
purine nucleoside triphosphate metabolic process GO:0009144 141 0.029
chemical homeostasis GO:0048878 292 0.029
purine nucleoside triphosphate catabolic process GO:0009146 122 0.029
regulation of cellular amino acid metabolic process GO:0006521 2 0.029
biological adhesion GO:0022610 110 0.029
inorganic ion transmembrane transport GO:0098660 229 0.029
negative regulation of apoptotic process GO:0043066 181 0.028
nucleoside triphosphate metabolic process GO:0009141 144 0.028
negative regulation of programmed cell death GO:0043069 183 0.028
nucleoside triphosphate catabolic process GO:0009143 123 0.028
negative regulation of cell communication GO:0010648 158 0.028
organonitrogen compound catabolic process GO:1901565 179 0.028
positive regulation of cellular biosynthetic process GO:0031328 295 0.028
purine ribonucleoside catabolic process GO:0046130 124 0.028
purine nucleotide catabolic process GO:0006195 136 0.028
heart contraction GO:0060047 57 0.028
Rat
ribose phosphate metabolic process GO:0019693 235 0.027
ribonucleoside metabolic process GO:0009119 174 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
guanosine containing compound metabolic process GO:1901068 74 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
response to camp GO:0051591 91 0.027
cell growth GO:0016049 104 0.027
ribonucleoside triphosphate metabolic process GO:0009199 141 0.027
divalent metal ion transport GO:0070838 132 0.027
purine nucleoside catabolic process GO:0006152 124 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.026
cellular response to growth factor stimulus GO:0071363 162 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
response to nutrient GO:0007584 248 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.026
response to estrogen GO:0043627 232 0.026
central nervous system development GO:0007417 311 0.025
dendrite development GO:0016358 72 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
positive regulation of gene expression GO:0010628 244 0.025
angiogenesis GO:0001525 53 0.025
programmed cell death GO:0012501 392 0.024
Rat
cellular nitrogen compound catabolic process GO:0044270 163 0.024
response to growth factor GO:0070848 189 0.024
positive regulation of cell communication GO:0010647 271 0.024
response to decreased oxygen levels GO:0036293 237 0.024
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
regulation of kinase activity GO:0043549 117 0.024
regulation of locomotion GO:0040012 148 0.024
multicellular organismal signaling GO:0035637 44 0.023
response to molecule of bacterial origin GO:0002237 194 0.023
Rat
response to metal ion GO:0010038 253 0.023
positive regulation of neuron differentiation GO:0045666 126 0.023
cellular amine metabolic process GO:0044106 38 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
gtp catabolic process GO:0006184 71 0.023
olfactory learning GO:0008355 1 0.023
cellular homeostasis GO:0019725 252 0.023
response to other organism GO:0051707 220 0.023
Rat
sensory perception GO:0007600 101 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
head development GO:0060322 247 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
circulatory system development GO:0072359 134 0.021
regulation of growth GO:0040008 105 0.021
regulation of ion transport GO:0043269 245 0.021
response to cytokine GO:0034097 215 0.021
regulation of smooth muscle cell proliferation GO:0048660 75 0.021
regulation of cellular component movement GO:0051270 150 0.021
cellular response to drug GO:0035690 30 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
calcium ion transport GO:0006816 131 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
locomotion GO:0040011 237 0.020
response to glucocorticoid GO:0051384 223 0.020
aromatic compound catabolic process GO:0019439 168 0.020
positive regulation of ion transport GO:0043270 94 0.020
ribonucleoside triphosphate catabolic process GO:0009203 122 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
negative regulation of molecular function GO:0044092 133 0.020
glycosyl compound catabolic process GO:1901658 126 0.020
developmental growth GO:0048589 100 0.020
guanosine containing compound catabolic process GO:1901069 71 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
secretion GO:0046903 307 0.020
learning or memory GO:0007611 90 0.020
Rat
response to monosaccharide GO:0034284 159 0.020
negative regulation of developmental process GO:0051093 125 0.020
amine metabolic process GO:0009308 38 0.019
regulation of transmembrane transport GO:0034762 122 0.019
protein oligomerization GO:0051259 191 0.019
single organism biosynthetic process GO:0044711 342 0.019
Rat
regulation of protein kinase activity GO:0045859 105 0.019
response to estradiol GO:0032355 164 0.019
regulation of blood circulation GO:1903522 110 0.019
Rat
blood vessel morphogenesis GO:0048514 58 0.019
regulation of ion transmembrane transport GO:0034765 121 0.018
memory GO:0007613 54 0.018
Rat
reproductive process GO:0022414 372 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
single organism reproductive process GO:0044702 297 0.018
cellular response to peptide GO:1901653 133 0.018
positive regulation of cellular component movement GO:0051272 102 0.018
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
embryonic appendage morphogenesis GO:0035113 4 0.018
retina morphogenesis in camera type eye GO:0060042 1 0.018
cell projection morphogenesis GO:0048858 123 0.018
regeneration GO:0031099 163 0.018
regulation of secretion GO:0051046 224 0.018
regulation of vasculature development GO:1901342 44 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.017
regulation of calcium ion transport GO:0051924 77 0.017
inorganic cation transmembrane transport GO:0098662 202 0.017
synaptic growth at neuromuscular junction GO:0051124 1 0.017
rhythmic process GO:0048511 156 0.017
vasculature development GO:0001944 70 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
multicellular organism reproduction GO:0032504 233 0.017
regulation of hydrolase activity GO:0051336 143 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
amide transport GO:0042886 105 0.017
organophosphate catabolic process GO:0046434 148 0.017
wound healing GO:0042060 122 0.017
response to nutrient levels GO:0031667 370 0.017
nucleotide catabolic process GO:0009166 139 0.017
cation transmembrane transport GO:0098655 263 0.017
response to oxidative stress GO:0006979 186 0.017
cellular lipid metabolic process GO:0044255 208 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
cellular chemical homeostasis GO:0055082 247 0.016
cognition GO:0050890 92 0.016
Rat
nucleoside catabolic process GO:0009164 126 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.016
ion homeostasis GO:0050801 212 0.016
glutamate receptor signaling pathway GO:0007215 43 0.016
camera type eye morphogenesis GO:0048593 2 0.016
response to purine containing compound GO:0014074 126 0.016
regulation of cellular component organization GO:0051128 368 0.016
cell morphogenesis GO:0000902 142 0.016
chemosensory behavior GO:0007635 2 0.016
response to external biotic stimulus GO:0043207 221 0.016
Rat
response to hydrogen peroxide GO:0042542 89 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
homeostatic process GO:0042592 331 0.016
transmission of nerve impulse GO:0019226 42 0.016
response to lipopolysaccharide GO:0032496 191 0.016
Rat
cellular response to stress GO:0033554 269 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
ras protein signal transduction GO:0007265 29 0.015
negative regulation of metabolic process GO:0009892 331 0.015
Rat
positive regulation of cell projection organization GO:0031346 111 0.015
gliogenesis GO:0042063 93 0.015
muscle structure development GO:0061061 87 0.015
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
regulation of body fluid levels GO:0050878 90 0.015
action potential GO:0001508 54 0.015
divalent inorganic cation transport GO:0072511 134 0.015
response to activity GO:0014823 73 0.015
macromolecule localization GO:0033036 252 0.015
Rat
glucose homeostasis GO:0042593 75 0.014
cell adhesion GO:0007155 110 0.014
central nervous system neuron axonogenesis GO:0021955 1 0.014
cell cycle GO:0007049 101 0.014
regulation of cell migration GO:0030334 128 0.014
cell migration GO:0016477 197 0.014
sensory organ development GO:0007423 74 0.014
positive regulation of molecular function GO:0044093 230 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
cardiovascular system development GO:0072358 134 0.014
response to amine GO:0014075 46 0.014
sodium ion transmembrane transport GO:0035725 67 0.014
nitrogen compound transport GO:0071705 229 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
Mouse
axon development GO:0061564 96 0.014
regulation of hormone levels GO:0010817 187 0.014
regulation of cell projection organization GO:0031344 175 0.014
positive regulation of transport GO:0051050 245 0.013
muscle cell proliferation GO:0033002 84 0.013
regulation of cell motility GO:2000145 131 0.013
regulation of hormone secretion GO:0046883 106 0.013
neuron death GO:0070997 127 0.013
neuronal action potential GO:0019228 35 0.013
cellular macromolecule localization GO:0070727 122 0.013
Rat
regulation of cellular component biogenesis GO:0044087 86 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
developmental process involved in reproduction GO:0003006 159 0.013
limb morphogenesis GO:0035108 4 0.013
response to corticosteroid GO:0031960 235 0.013
single organism intracellular transport GO:1902582 166 0.013
Rat
regulation of cellular localization GO:0060341 263 0.013
organic acid biosynthetic process GO:0016053 83 0.013
cell part morphogenesis GO:0032990 123 0.013
cytoskeleton organization GO:0007010 111 0.013
negative regulation of protein phosphorylation GO:0001933 44 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
carbohydrate metabolic process GO:0005975 130 0.013
rho protein signal transduction GO:0007266 11 0.013
negative regulation of nervous system development GO:0051961 79 0.013
single organism behavior GO:0044708 130 0.013
Rat
regulation of homeostatic process GO:0032844 101 0.013
membrane depolarization during cardiac muscle cell action potential GO:0086012 1 0.013
aging GO:0007568 241 0.013
calcium ion homeostasis GO:0055074 162 0.013
embryonic limb morphogenesis GO:0030326 4 0.013
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.013
purine nucleotide biosynthetic process GO:0006164 83 0.013
Rat
axis specification GO:0009798 4 0.013
cellular amino acid biosynthetic process GO:0008652 32 0.013
cellular response to external stimulus GO:0071496 118 0.013
gamete generation GO:0007276 124 0.013
organelle organization GO:0006996 266 0.013
Rat
negative regulation of catalytic activity GO:0043086 103 0.013
negative regulation of biosynthetic process GO:0009890 168 0.012
Rat
positive regulation of intracellular signal transduction GO:1902533 138 0.012
regulation of peptide transport GO:0090087 87 0.012
adult locomotory behavior GO:0008344 4 0.012
spermatogenesis GO:0007283 99 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
positive regulation of locomotion GO:0040017 102 0.012
regulation of synapse assembly GO:0051963 15 0.012
positive regulation of gtpase activity GO:0043547 47 0.012
positive regulation of signal transduction GO:0009967 175 0.012
organ regeneration GO:0031100 101 0.012
response to ethanol GO:0045471 162 0.012
multicellular organism growth GO:0035264 1 0.012
response to glucose GO:0009749 136 0.012
regulation of gtpase activity GO:0043087 57 0.012
regulation of purine nucleotide catabolic process GO:0033121 65 0.012
positive regulation of protein modification process GO:0031401 142 0.012
regulation of establishment of planar polarity GO:0090175 2 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
establishment of tissue polarity GO:0007164 2 0.012
regulation of neuron death GO:1901214 115 0.012
smooth muscle cell proliferation GO:0048659 77 0.012
appendage morphogenesis GO:0035107 4 0.012
regulation of synaptic plasticity GO:0048167 70 0.012
negative regulation of protein kinase activity GO:0006469 23 0.011
regulation of insulin secretion GO:0050796 65 0.011
regulation of cell cycle GO:0051726 73 0.011
gastrulation GO:0007369 2 0.011
salivary gland morphogenesis GO:0007435 1 0.011
respiratory gaseous exchange GO:0007585 4 0.011
response to toxic substance GO:0009636 133 0.011
adult behavior GO:0030534 16 0.011
lipid metabolic process GO:0006629 283 0.011
response to wounding GO:0009611 254 0.011
Rat
regulation of catabolic process GO:0009894 113 0.011
cation homeostasis GO:0055080 195 0.011
anion transmembrane transport GO:0098656 77 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
positive regulation of growth GO:0045927 55 0.011
secretion by cell GO:0032940 248 0.011
regulation of synaptic transmission GO:0050804 141 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
embryonic pattern specification GO:0009880 1 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
tube development GO:0035295 89 0.011
actin filament based movement GO:0030048 16 0.011
cytoplasmic transport GO:0016482 115 0.011
Rat
negative regulation of phosphate metabolic process GO:0045936 80 0.011
Rat
negative regulation of gene expression GO:0010629 199 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
regulation of small gtpase mediated signal transduction GO:0051056 48 0.011
sexual reproduction GO:0019953 148 0.011
feeding behavior GO:0007631 53 0.011
protein transport GO:0015031 132 0.011
Rat
insulin like growth factor receptor signaling pathway GO:0048009 3 0.011
reproductive system development GO:0061458 128 0.010
male gamete generation GO:0048232 99 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.010
Rat
cellular response to oxygen levels GO:0071453 60 0.010
response to light stimulus GO:0009416 52 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
proteolysis GO:0006508 175 0.010
regulation of nucleoside metabolic process GO:0009118 66 0.010
blood circulation GO:0008015 183 0.010
Rat
blood vessel development GO:0001568 69 0.010
dendrite morphogenesis GO:0048813 43 0.010
muscle tissue development GO:0060537 58 0.010
response to organophosphorus GO:0046683 102 0.010
axonogenesis GO:0007409 71 0.010
positive regulation of kinase activity GO:0033674 77 0.010
response to acid chemical GO:0001101 222 0.010

Pde10a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
myopathy DOID:423 0 0.010
muscular disease DOID:0080000 0 0.010
musculoskeletal system disease DOID:17 0 0.010
muscle tissue disease DOID:66 0 0.010