Rattus norvegicus

127 known processes

Sirt4

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)

Sirt4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.065
Mouse
cellular amino acid metabolic process GO:0006520 107 0.049
Mouse
oxoacid metabolic process GO:0043436 290 0.044
Mouse
carboxylic acid metabolic process GO:0019752 289 0.044
Mouse
negative regulation of metabolic process GO:0009892 331 0.040
regulation of cellular ketone metabolic process GO:0010565 27 0.039
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
catabolic process GO:0009056 351 0.037
response to inorganic substance GO:0010035 377 0.034
cellular catabolic process GO:0044248 295 0.034
single organism catabolic process GO:0044712 283 0.033
cellular response to oxygen containing compound GO:1901701 386 0.033
regulation of phosphate metabolic process GO:0019220 349 0.032
rna metabolic process GO:0016070 406 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.031
nucleic acid templated transcription GO:0097659 379 0.030
regulation of programmed cell death GO:0043067 341 0.029
transcription dna templated GO:0006351 377 0.029
apoptotic process GO:0006915 381 0.029
rna biosynthetic process GO:0032774 380 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
neuron projection development GO:0031175 273 0.028
cellular amine metabolic process GO:0044106 38 0.028
amine metabolic process GO:0009308 38 0.027
reproductive process GO:0022414 372 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
response to oxidative stress GO:0006979 186 0.027
protein phosphorylation GO:0006468 345 0.026
regulation of apoptotic process GO:0042981 335 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
response to hypoxia GO:0001666 231 0.026
regulation of molecular function GO:0065009 398 0.026
response to acid chemical GO:0001101 222 0.026
response to extracellular stimulus GO:0009991 380 0.026
cellular response to stress GO:0033554 269 0.025
neuron differentiation GO:0030182 368 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
response to peptide GO:1901652 292 0.025
cellular ketone metabolic process GO:0042180 51 0.024
Mouse
anion transport GO:0006820 178 0.024
response to oxygen levels GO:0070482 265 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
cell projection organization GO:0030030 302 0.024
intracellular signal transduction GO:0035556 314 0.024
protein complex biogenesis GO:0070271 263 0.024
regulation of rna metabolic process GO:0051252 391 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
regulation of rna biosynthetic process GO:2001141 381 0.023
regulation of signal transduction GO:0009966 318 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
lipid metabolic process GO:0006629 283 0.023
Mouse
neuron development GO:0048666 286 0.023
organophosphate metabolic process GO:0019637 370 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
cellular component assembly GO:0022607 360 0.023
programmed cell death GO:0012501 392 0.023
positive regulation of signaling GO:0023056 270 0.022
cellular response to endogenous stimulus GO:0071495 377 0.022
response to growth factor GO:0070848 189 0.022
response to nutrient levels GO:0031667 370 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
Mouse
ribose phosphate metabolic process GO:0019693 235 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
response to insulin GO:0032868 133 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
response to nutrient GO:0007584 248 0.021
protein complex assembly GO:0006461 263 0.021
regulation of protein metabolic process GO:0051246 289 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
Mouse
response to decreased oxygen levels GO:0036293 237 0.021
regulation of catalytic activity GO:0050790 304 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
organic substance catabolic process GO:1901575 316 0.020
response to reactive oxygen species GO:0000302 120 0.020
cellular component biogenesis GO:0044085 368 0.020
regulation of cellular component organization GO:0051128 368 0.020
regulation of cell proliferation GO:0042127 359 0.020
secretion by cell GO:0032940 248 0.019
Human Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
positive regulation of cell death GO:0010942 184 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
negative regulation of cell death GO:0060548 229 0.019
transcription from rna polymerase ii promoter GO:0006366 252 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
purine containing compound metabolic process GO:0072521 253 0.019
regulation of cell development GO:0060284 263 0.019
oxidation reduction process GO:0055114 304 0.018
Mouse
negative regulation of programmed cell death GO:0043069 183 0.018
multi organism reproductive process GO:0044703 262 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
regulation of transcription dna templated GO:0006355 374 0.018
protein complex subunit organization GO:0071822 302 0.018
negative regulation of signaling GO:0023057 157 0.018
Human Mouse
positive regulation of rna metabolic process GO:0051254 203 0.018
regulation of neuron projection development GO:0010975 161 0.018
response to radiation GO:0009314 137 0.018
regulation of neuron differentiation GO:0045664 208 0.018
nucleoside phosphate catabolic process GO:1901292 140 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
regulation of hormone levels GO:0010817 187 0.017
Human Mouse
regulation of multicellular organismal development GO:2000026 376 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
single organism biosynthetic process GO:0044711 342 0.017
Mouse
regulation of hydrolase activity GO:0051336 143 0.017
positive regulation of molecular function GO:0044093 230 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
secretion GO:0046903 307 0.016
Human Mouse
regulation of cell projection organization GO:0031344 175 0.016
positive regulation of gene expression GO:0010628 244 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
central nervous system development GO:0007417 311 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
response to wounding GO:0009611 254 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
homeostatic process GO:0042592 331 0.016
single organism reproductive process GO:0044702 297 0.016
regulation of cell differentiation GO:0045595 320 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
macromolecular complex assembly GO:0065003 273 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
negative regulation of cell communication GO:0010648 158 0.016
Human Mouse
axis specification GO:0009798 4 0.016
intracellular transport GO:0046907 185 0.016
negative regulation of gene expression GO:0010629 199 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
nucleotide metabolic process GO:0009117 279 0.016
establishment of protein localization GO:0045184 141 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
response to glucocorticoid GO:0051384 223 0.015
response to vitamin GO:0033273 131 0.015
cell cell signaling GO:0007267 335 0.015
Human Mouse
positive regulation of nervous system development GO:0051962 178 0.015
response to hydrogen peroxide GO:0042542 89 0.015
heterocycle catabolic process GO:0046700 167 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
cellular response to peptide GO:1901653 133 0.015
response to peptide hormone GO:0043434 278 0.015
positive regulation of cell communication GO:0010647 271 0.015
positive regulation of developmental process GO:0051094 283 0.015
macromolecule localization GO:0033036 252 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
regulation of system process GO:0044057 208 0.015
cellular homeostasis GO:0019725 252 0.015
regulation of nervous system development GO:0051960 264 0.015
regulation of neurogenesis GO:0050767 247 0.014
cellular lipid metabolic process GO:0044255 208 0.014
Mouse
organophosphate biosynthetic process GO:0090407 143 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
single organism organelle organization GO:1902589 180 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
response to cytokine GO:0034097 215 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
reproduction GO:0000003 245 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
nucleoside metabolic process GO:0009116 179 0.014
antigen receptor mediated signaling pathway GO:0050851 1 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
mapk cascade GO:0000165 140 0.014
brain development GO:0007420 247 0.014
circulatory system process GO:0003013 183 0.014
ras protein signal transduction GO:0007265 29 0.014
regeneration GO:0031099 163 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
growth GO:0040007 165 0.013
cell type specific apoptotic process GO:0097285 134 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
response to metal ion GO:0010038 253 0.013
protein transport GO:0015031 132 0.013
neurological system process GO:0050877 219 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
aromatic compound catabolic process GO:0019439 168 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
multi multicellular organism process GO:0044706 138 0.013
organophosphate catabolic process GO:0046434 148 0.013
response to external biotic stimulus GO:0043207 221 0.013
response to ketone GO:1901654 182 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
response to toxic substance GO:0009636 133 0.013
transmembrane transport GO:0055085 412 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
regulation of cell motility GO:2000145 131 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
response to ethanol GO:0045471 162 0.013
regulation of cell migration GO:0030334 128 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
cation transport GO:0006812 382 0.013
chemical homeostasis GO:0048878 292 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
peptidyl amino acid modification GO:0018193 126 0.013
Mouse
positive regulation of neuron projection development GO:0010976 99 0.013
organelle organization GO:0006996 266 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
Mouse
neuron death GO:0070997 127 0.012
regulation of kinase activity GO:0043549 117 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
positive regulation of cell development GO:0010720 176 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
cellular response to oxidative stress GO:0034599 76 0.012
protein oligomerization GO:0051259 191 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
lipid storage GO:0019915 1 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
behavior GO:0007610 205 0.012
positive regulation of signal transduction GO:0009967 175 0.012
regulation of phosphorylation GO:0042325 248 0.012
regulation of transferase activity GO:0051338 123 0.012
head development GO:0060322 247 0.012
cardiovascular system development GO:0072358 134 0.012
response to estrogen GO:0043627 232 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
aging GO:0007568 241 0.012
proteolysis GO:0006508 175 0.012
regulation of anatomical structure size GO:0090066 135 0.012
metal ion transport GO:0030001 289 0.012
multicellular organism reproduction GO:0032504 233 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
response to amino acid GO:0043200 75 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
response to carbohydrate GO:0009743 183 0.012
positive regulation of protein modification process GO:0031401 142 0.011
nucleotide catabolic process GO:0009166 139 0.011
anterior posterior pattern specification GO:0009952 1 0.011
gastrulation GO:0007369 2 0.011
developmental process involved in reproduction GO:0003006 159 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
carbohydrate metabolic process GO:0005975 130 0.011
Mouse
neuron projection morphogenesis GO:0048812 122 0.011
cation homeostasis GO:0055080 195 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
monosaccharide metabolic process GO:0005996 61 0.011
cell migration GO:0016477 197 0.011
regulation of cellular localization GO:0060341 263 0.011
ion homeostasis GO:0050801 212 0.011
protein localization GO:0008104 191 0.011
female pregnancy GO:0007565 122 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
regulation of locomotion GO:0040012 148 0.011
cellular chemical homeostasis GO:0055082 247 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
nitrogen compound transport GO:0071705 229 0.011
Human Mouse
synaptic growth at neuromuscular junction GO:0051124 1 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
signal release GO:0023061 145 0.011
Human Mouse
negative regulation of rna biosynthetic process GO:1902679 118 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
meiotic cell cycle process GO:1903046 3 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
response to corticosteroid GO:0031960 235 0.011
embryonic pattern specification GO:0009880 1 0.011
blood circulation GO:0008015 183 0.011
regulation of protein modification process GO:0031399 194 0.010
spindle organization GO:0007051 2 0.010
dna metabolic process GO:0006259 96 0.010
negative regulation of molecular function GO:0044092 133 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
Mouse
response to axon injury GO:0048678 59 0.010
cellular response to external stimulus GO:0071496 118 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
regulation of secretion by cell GO:1903530 208 0.010
Human Mouse
defense response to gram negative bacterium GO:0050829 3 0.010
hormone secretion GO:0046879 115 0.010
Human Mouse
ion transmembrane transport GO:0034220 365 0.010
gland development GO:0048732 155 0.010
purine nucleoside catabolic process GO:0006152 124 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
synaptic transmission GO:0007268 235 0.010
sex differentiation GO:0007548 113 0.010
cell morphogenesis GO:0000902 142 0.010
membrane organization GO:0061024 94 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
dendrite development GO:0016358 72 0.010
localization of cell GO:0051674 202 0.010

Sirt4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
central nervous system disease DOID:331 0 0.014
musculoskeletal system disease DOID:17 0 0.014
disease of metabolism DOID:0014667 0 0.012