Rattus norvegicus

52 known processes

Pi4k2a

phosphatidylinositol 4-kinase type 2 alpha

(Aliases: Pi4KII)

Pi4k2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of transcription dna templated GO:0006355 374 0.185
neuron differentiation GO:0030182 368 0.166
anatomical structure morphogenesis GO:0009653 298 0.148
cellular response to oxygen containing compound GO:1901701 386 0.124
transcription dna templated GO:0006351 377 0.111
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.109
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.102
negative regulation of metabolic process GO:0009892 331 0.094
negative regulation of macromolecule metabolic process GO:0010605 260 0.093
regulation of molecular function GO:0065009 398 0.090
response to metal ion GO:0010038 253 0.090
rna metabolic process GO:0016070 406 0.089
response to inorganic substance GO:0010035 377 0.081
positive regulation of nucleic acid templated transcription GO:1903508 197 0.080
regulation of nucleic acid templated transcription GO:1903506 380 0.078
regulation of protein metabolic process GO:0051246 289 0.074
transcription from rna polymerase ii promoter GO:0006366 252 0.074
regulation of rna biosynthetic process GO:2001141 381 0.072
negative regulation of gene expression GO:0010629 199 0.072
cellular response to nitrogen compound GO:1901699 210 0.069
response to lipopolysaccharide GO:0032496 191 0.067
cellular response to oxidative stress GO:0034599 76 0.066
response to purine containing compound GO:0014074 126 0.065
rna biosynthetic process GO:0032774 380 0.065
regulation of cellular component organization GO:0051128 368 0.064
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.063
regulation of cell development GO:0060284 263 0.063
response to cytokine GO:0034097 215 0.061
negative regulation of transcription dna templated GO:0045892 116 0.061
response to extracellular stimulus GO:0009991 380 0.060
cellular response to endogenous stimulus GO:0071495 377 0.060
cellular response to stress GO:0033554 269 0.059
nucleic acid templated transcription GO:0097659 379 0.059
intracellular signal transduction GO:0035556 314 0.058
macromolecular complex assembly GO:0065003 273 0.058
regulation of phosphate metabolic process GO:0019220 349 0.057
regulation of rna metabolic process GO:0051252 391 0.055
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.054
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.054
regulation of phosphorus metabolic process GO:0051174 349 0.053
regulation of signal transduction GO:0009966 318 0.052
negative regulation of cell death GO:0060548 229 0.051
response to biotic stimulus GO:0009607 226 0.051
positive regulation of catalytic activity GO:0043085 184 0.050
regulation of neuron death GO:1901214 115 0.050
cellular chemical homeostasis GO:0055082 247 0.049
cellular response to cytokine stimulus GO:0071345 127 0.049
response to molecule of bacterial origin GO:0002237 194 0.049
cellular response to biotic stimulus GO:0071216 59 0.048
neuron projection development GO:0031175 273 0.048
regulation of nervous system development GO:0051960 264 0.047
negative regulation of rna metabolic process GO:0051253 123 0.047
neurological system process GO:0050877 219 0.047
cell projection organization GO:0030030 302 0.046
reproduction GO:0000003 245 0.046
negative regulation of cellular metabolic process GO:0031324 281 0.046
negative regulation of cellular biosynthetic process GO:0031327 161 0.045
multi organism reproductive process GO:0044703 262 0.044
neuron development GO:0048666 286 0.044
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.043
muscle system process GO:0003012 115 0.043
macromolecular complex subunit organization GO:0043933 339 0.043
regulation of cellular protein metabolic process GO:0032268 267 0.042
organelle organization GO:0006996 266 0.042
positive regulation of transcription dna templated GO:0045893 197 0.042
positive regulation of biosynthetic process GO:0009891 319 0.042
single organism reproductive process GO:0044702 297 0.042
neuron apoptotic process GO:0051402 88 0.041
response to other organism GO:0051707 220 0.041
positive regulation of phosphorus metabolic process GO:0010562 262 0.041
cellular homeostasis GO:0019725 252 0.040
positive regulation of gene expression GO:0010628 244 0.040
single organism intracellular transport GO:1902582 166 0.040
cellular cation homeostasis GO:0030003 180 0.040
regulation of membrane potential GO:0042391 110 0.039
cellular response to organic cyclic compound GO:0071407 202 0.039
response to peptide GO:1901652 292 0.039
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.038
chemical homeostasis GO:0048878 292 0.038
regulation of catalytic activity GO:0050790 304 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.038
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.037
negative regulation of neuron death GO:1901215 69 0.037
negative regulation of rna biosynthetic process GO:1902679 118 0.036
neuron death GO:0070997 127 0.036
positive regulation of transport GO:0051050 245 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
macromolecule localization GO:0033036 252 0.036
cell part morphogenesis GO:0032990 123 0.035
ion homeostasis GO:0050801 212 0.035
response to decreased oxygen levels GO:0036293 237 0.035
cellular component movement GO:0006928 248 0.034
negative regulation of apoptotic process GO:0043066 181 0.034
cellular response to reactive oxygen species GO:0034614 55 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.034
cellular response to peptide hormone stimulus GO:0071375 120 0.034
negative regulation of biosynthetic process GO:0009890 168 0.034
cell morphogenesis GO:0000902 142 0.034
response to external biotic stimulus GO:0043207 221 0.034
response to radiation GO:0009314 137 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
cellular ion homeostasis GO:0006873 184 0.033
response to camp GO:0051591 91 0.033
response to bacterium GO:0009617 200 0.033
positive regulation of nervous system development GO:0051962 178 0.033
regulation of cell differentiation GO:0045595 320 0.033
regulation of lipid metabolic process GO:0019216 68 0.033
positive regulation of phosphate metabolic process GO:0045937 262 0.033
reproductive process GO:0022414 372 0.032
cation homeostasis GO:0055080 195 0.032
cellular response to organonitrogen compound GO:0071417 197 0.032
cellular response to external stimulus GO:0071496 118 0.032
negative regulation of programmed cell death GO:0043069 183 0.031
behavior GO:0007610 205 0.031
cellular component biogenesis GO:0044085 368 0.030
cellular response to lipid GO:0071396 201 0.030
response to nutrient levels GO:0031667 370 0.030
negative regulation of signaling GO:0023057 157 0.029
response to insulin GO:0032868 133 0.029
response to oxidative stress GO:0006979 186 0.029
protein complex subunit organization GO:0071822 302 0.029
cell morphogenesis involved in differentiation GO:0000904 119 0.029
inorganic ion transmembrane transport GO:0098660 229 0.029
regulation of intracellular signal transduction GO:1902531 218 0.029
protein complex biogenesis GO:0070271 263 0.028
potassium ion transport GO:0006813 97 0.028
single organism cellular localization GO:1902580 102 0.028
positive regulation of nucleoside metabolic process GO:0045979 55 0.028
aging GO:0007568 241 0.027
response to acid chemical GO:0001101 222 0.027
multicellular organismal reproductive process GO:0048609 233 0.027
regulation of programmed cell death GO:0043067 341 0.026
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
metal ion homeostasis GO:0055065 186 0.026
regulation of system process GO:0044057 208 0.026
regulation of catabolic process GO:0009894 113 0.026
positive regulation of rna biosynthetic process GO:1902680 197 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
cellular component morphogenesis GO:0032989 155 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
locomotion GO:0040011 237 0.026
tube development GO:0035295 89 0.025
cellular response to peptide GO:1901653 133 0.025
negative regulation of nucleic acid templated transcription GO:1903507 117 0.025
regulation of apoptotic process GO:0042981 335 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
regulation of neuron differentiation GO:0045664 208 0.024
circadian rhythm GO:0007623 88 0.024
oxoacid metabolic process GO:0043436 290 0.024
cell projection morphogenesis GO:0048858 123 0.024
protein complex assembly GO:0006461 263 0.024
anion transport GO:0006820 178 0.024
transmembrane transport GO:0055085 412 0.024
response to peptide hormone GO:0043434 278 0.023
positive regulation of neurogenesis GO:0050769 165 0.023
reproductive structure development GO:0048608 128 0.023
positive regulation of molecular function GO:0044093 230 0.023
muscle contraction GO:0006936 88 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.023
purine nucleotide metabolic process GO:0006163 229 0.022
ion transmembrane transport GO:0034220 365 0.022
negative regulation of signal transduction GO:0009968 83 0.022
cellular ketone metabolic process GO:0042180 51 0.021
organ morphogenesis GO:0009887 75 0.021
cellular response to molecule of bacterial origin GO:0071219 56 0.021
lipid metabolic process GO:0006629 283 0.021
vesicle mediated transport GO:0016192 181 0.021
response to estrogen GO:0043627 232 0.021
synaptic transmission GO:0007268 235 0.020
positive regulation of developmental process GO:0051094 283 0.020
organophosphate metabolic process GO:0019637 370 0.020
regulation of neuron projection development GO:0010975 161 0.020
negative regulation of cell communication GO:0010648 158 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
catabolic process GO:0009056 351 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
regulation of homeostatic process GO:0032844 101 0.019
regulation of hydrolase activity GO:0051336 143 0.019
sexual reproduction GO:0019953 148 0.019
response to estradiol GO:0032355 164 0.019
cell type specific apoptotic process GO:0097285 134 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
rhythmic process GO:0048511 156 0.019
learning or memory GO:0007611 90 0.019
cellular component assembly GO:0022607 360 0.019
multi multicellular organism process GO:0044706 138 0.019
response to mechanical stimulus GO:0009612 134 0.019
response to growth factor GO:0070848 189 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
metal ion transport GO:0030001 289 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
positive regulation of hydrolase activity GO:0051345 86 0.018
positive regulation of catabolic process GO:0009896 78 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
regulation of cell proliferation GO:0042127 359 0.018
cellular protein localization GO:0034613 122 0.018
cellular response to nitrite GO:0071250 2 0.018
response to hypoxia GO:0001666 231 0.018
multicellular organism reproduction GO:0032504 233 0.018
cellular response to lipopolysaccharide GO:0071222 55 0.017
membrane organization GO:0061024 94 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
regulation of hormone levels GO:0010817 187 0.017
regulation of secretion by cell GO:1903530 208 0.017
cardiovascular system development GO:0072358 134 0.017
organelle localization GO:0051640 55 0.017
regulation of phosphorylation GO:0042325 248 0.017
single organism biosynthetic process GO:0044711 342 0.017
dna metabolic process GO:0006259 96 0.017
sensory perception GO:0007600 101 0.017
cell cell signaling GO:0007267 335 0.017
vascular process in circulatory system GO:0003018 96 0.017
cellular amine metabolic process GO:0044106 38 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
positive regulation of protein modification process GO:0031401 142 0.017
tissue development GO:0009888 252 0.016
single organism organelle organization GO:1902589 180 0.016
response to carbohydrate GO:0009743 183 0.016
response to toxic substance GO:0009636 133 0.016
proteolysis GO:0006508 175 0.016
regulation of transmembrane transport GO:0034762 122 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
response to alkaloid GO:0043279 132 0.016
single organism catabolic process GO:0044712 283 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
neuron projection morphogenesis GO:0048812 122 0.016
steroid metabolic process GO:0008202 73 0.016
response to oxygen levels GO:0070482 265 0.016
regulation of cell projection organization GO:0031344 175 0.015
cellular response to insulin stimulus GO:0032869 81 0.015
cell migration GO:0016477 197 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
regulation of mapk cascade GO:0043408 116 0.015
organic substance catabolic process GO:1901575 316 0.015
intracellular transport GO:0046907 185 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
response to starvation GO:0042594 59 0.015
hexose metabolic process GO:0019318 58 0.015
neuromuscular synaptic transmission GO:0007274 2 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
gastrulation GO:0007369 2 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
regulation of secretion GO:0051046 224 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
single organism behavior GO:0044708 130 0.015
vasculature development GO:0001944 70 0.015
cell cycle GO:0007049 101 0.015
response to electrical stimulus GO:0051602 56 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.014
regulation of cell migration GO:0030334 128 0.014
organic acid metabolic process GO:0006082 292 0.014
dephosphorylation GO:0016311 98 0.014
olfactory learning GO:0008355 1 0.014
purine containing compound metabolic process GO:0072521 253 0.014
inorganic cation transmembrane transport GO:0098662 202 0.014
cellular potassium ion transport GO:0071804 72 0.014
circadian regulation of gene expression GO:0032922 3 0.014
circulatory system development GO:0072359 134 0.014
regulation of rab protein signal transduction GO:0032483 3 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
energy derivation by oxidation of organic compounds GO:0015980 46 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
regulation of cellular localization GO:0060341 263 0.014
calcium ion homeostasis GO:0055074 162 0.014
amine metabolic process GO:0009308 38 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
maintenance of location GO:0051235 17 0.014
cellular response to interleukin 1 GO:0071347 37 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
secretion GO:0046903 307 0.013
protein localization GO:0008104 191 0.013
response to activity GO:0014823 73 0.013
sensory organ development GO:0007423 74 0.013
aromatic compound catabolic process GO:0019439 168 0.013
response to glucose GO:0009749 136 0.013
heart contraction GO:0060047 57 0.013
cellular catabolic process GO:0044248 295 0.013
cation transmembrane transport GO:0098655 263 0.013
negative regulation of molecular function GO:0044092 133 0.013
regulation of metal ion transport GO:0010959 118 0.013
nucleotide catabolic process GO:0009166 139 0.013
positive regulation of multicellular organismal process GO:0051240 387 0.013
growth GO:0040007 165 0.013
regulation of muscle system process GO:0090257 79 0.013
regulation of neurogenesis GO:0050767 247 0.013
response to hydrogen peroxide GO:0042542 89 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
organophosphate catabolic process GO:0046434 148 0.013
ncrna processing GO:0034470 3 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.013
central nervous system development GO:0007417 311 0.012
gamete generation GO:0007276 124 0.012
regulation of cellular component movement GO:0051270 150 0.012
regulation of growth GO:0040008 105 0.012
dendrite morphogenesis GO:0048813 43 0.012
chemosensory behavior GO:0007635 2 0.012
dendrite development GO:0016358 72 0.012
response to nutrient GO:0007584 248 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
norepinephrine metabolic process GO:0042415 3 0.012
phototransduction visible light GO:0007603 2 0.012
nucleotide metabolic process GO:0009117 279 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
chromosome segregation GO:0007059 2 0.012
ras protein signal transduction GO:0007265 29 0.012
response to monosaccharide GO:0034284 159 0.012
defense response GO:0006952 194 0.012
intracellular receptor signaling pathway GO:0030522 35 0.012
homeostatic process GO:0042592 331 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
protein phosphorylation GO:0006468 345 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
positive regulation of rab gtpase activity GO:0032851 3 0.012
regulation of cell cycle GO:0051726 73 0.012
positive regulation of gtp catabolic process GO:0033126 48 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
peptidyl amino acid modification GO:0018193 126 0.012
blood circulation GO:0008015 183 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
cation transport GO:0006812 382 0.012
negative regulation of neuron apoptotic process GO:0043524 45 0.012
epithelium development GO:0060429 96 0.011
cellular protein complex assembly GO:0043623 44 0.011
programmed cell death GO:0012501 392 0.011
response to ethanol GO:0045471 162 0.011
circulatory system process GO:0003013 183 0.011
regulation of calcium ion transport GO:0051924 77 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
generation of precursor metabolites and energy GO:0006091 62 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
cytoplasmic transport GO:0016482 115 0.011
positive regulation of transferase activity GO:0051347 81 0.011
response to organophosphorus GO:0046683 102 0.011
secretion by cell GO:0032940 248 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
lipid biosynthetic process GO:0008610 128 0.011
regulation of protein kinase activity GO:0045859 105 0.011
rna localization GO:0006403 4 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
multicellular organism growth GO:0035264 1 0.011
regulation of response to stress GO:0080134 126 0.011
nitrogen compound transport GO:0071705 229 0.011
anterior posterior pattern specification GO:0009952 1 0.011
response to ionizing radiation GO:0010212 59 0.011
regulation of transporter activity GO:0032409 50 0.011
axis specification GO:0009798 4 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
cellular response to acid chemical GO:0071229 75 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
head development GO:0060322 247 0.011
divalent inorganic cation transport GO:0072511 134 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
response to ammonium ion GO:0060359 71 0.011
macroautophagy GO:0016236 4 0.010
female pregnancy GO:0007565 122 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
hormone secretion GO:0046879 115 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
memory GO:0007613 54 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.010
olfactory behavior GO:0042048 2 0.010
nucleoside metabolic process GO:0009116 179 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
regulation of kinase activity GO:0043549 117 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
sensory perception of light stimulus GO:0050953 3 0.010
regulation of protein modification process GO:0031399 194 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 4 0.010
gonad development GO:0008406 104 0.010

Pi4k2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.025
inherited metabolic disorder DOID:655 0 0.022
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
musculoskeletal system disease DOID:17 0 0.017
muscular disease DOID:0080000 0 0.016
muscle tissue disease DOID:66 0 0.016
myopathy DOID:423 0 0.012
central nervous system disease DOID:331 0 0.012