Rattus norvegicus

19 known processes

Lum

lumican

Lum biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to mechanical stimulus GO:0009612 134 0.809
Rat
growth plate cartilage development GO:0003417 2 0.598
extracellular matrix organization GO:0030198 13 0.591
Zebrafish
odontogenesis GO:0042476 32 0.554
Rat
cartilage development GO:0051216 22 0.510
cellular response to vitamin e GO:0071306 3 0.469
renal system development GO:0072001 67 0.388
Rat
skeletal system development GO:0001501 41 0.370
extracellular structure organization GO:0043062 13 0.337
Zebrafish
tissue development GO:0009888 252 0.316
response to transforming growth factor beta GO:0071559 46 0.310
anatomical structure morphogenesis GO:0009653 298 0.306
Zebrafish Rat
response to camp GO:0051591 91 0.289
response to corticosteroid GO:0031960 235 0.257
peptide cross linking GO:0018149 1 0.255
cellular response to endogenous stimulus GO:0071495 377 0.237
developmental growth GO:0048589 100 0.215
response to nutrient GO:0007584 248 0.215
cellular response to peptide GO:1901653 133 0.207
response to growth factor GO:0070848 189 0.206
response to fluoride GO:1902617 3 0.202
protein heterooligomerization GO:0051291 89 0.197
response to lipopolysaccharide GO:0032496 191 0.185
Rat
endochondral bone growth GO:0003416 3 0.181
response to external biotic stimulus GO:0043207 221 0.179
Rat
cellular response to organonitrogen compound GO:0071417 197 0.178
cellular response to fluoride GO:1902618 1 0.172
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.171
response to biotic stimulus GO:0009607 226 0.165
Rat
response to molecule of bacterial origin GO:0002237 194 0.162
Rat
muscle tissue development GO:0060537 58 0.159
Rat
response to purine containing compound GO:0014074 126 0.158
response to inorganic substance GO:0010035 377 0.153
single organism reproductive process GO:0044702 297 0.140
Rat
macromolecular complex subunit organization GO:0043933 339 0.138
Zebrafish
response to tumor necrosis factor GO:0034612 56 0.136
response to nutrient levels GO:0031667 370 0.131
aorta development GO:0035904 2 0.126
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.126
response to vitamin e GO:0033197 24 0.124
regulation of canonical wnt signaling pathway GO:0060828 4 0.120
intracellular signal transduction GO:0035556 314 0.119
response to other organism GO:0051707 220 0.119
Rat
cellular response to hormone stimulus GO:0032870 247 0.115
developmental growth involved in morphogenesis GO:0060560 33 0.110
protein complex biogenesis GO:0070271 263 0.109
reproductive structure development GO:0048608 128 0.109
Rat
extracellular fibril organization GO:0043206 1 0.108
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.107
cellular response to peptide hormone stimulus GO:0071375 120 0.106
organ morphogenesis GO:0009887 75 0.105
Zebrafish Rat
cellular response to organic cyclic compound GO:0071407 202 0.103
ossification GO:0001503 70 0.098
response to bacterium GO:0009617 200 0.097
Rat
endochondral bone morphogenesis GO:0060350 7 0.097
cellular component biogenesis GO:0044085 368 0.096
placenta development GO:0001890 22 0.095
Rat
cellular response to external stimulus GO:0071496 118 0.094
cellular component assembly GO:0022607 360 0.090
protein complex subunit organization GO:0071822 302 0.090
Zebrafish
cellular response to nitrogen compound GO:1901699 210 0.089
organ growth GO:0035265 24 0.088
macromolecular complex assembly GO:0065003 273 0.088
negative regulation of biomineral tissue development GO:0070168 2 0.085
aging GO:0007568 241 0.084
Rat
response to peptide GO:1901652 292 0.079
cellular response to alkaloid GO:0071312 25 0.078
enzyme linked receptor protein signaling pathway GO:0007167 116 0.077
response to extracellular stimulus GO:0009991 380 0.077
cellular response to growth factor stimulus GO:0071363 162 0.076
skin morphogenesis GO:0043589 2 0.073
regulation of rna biosynthetic process GO:2001141 381 0.072
Mouse
cellular response to oxygen containing compound GO:1901701 386 0.072
connective tissue development GO:0061448 33 0.071
tooth eruption GO:0044691 1 0.070
muscle organ development GO:0007517 50 0.070
Rat
urogenital system development GO:0001655 78 0.069
Rat
response to ionizing radiation GO:0010212 59 0.068
response to peptide hormone GO:0043434 278 0.067
response to epidermal growth factor GO:0070849 18 0.066
response to estrogen GO:0043627 232 0.064
response to norepinephrine GO:0071873 5 0.063
sulfur compound metabolic process GO:0006790 70 0.062
response to glucocorticoid GO:0051384 223 0.061
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.058
response to catecholamine GO:0071869 16 0.058
kidney development GO:0001822 67 0.058
Rat
cellular response to nicotine GO:0071316 7 0.058
development of primary sexual characteristics GO:0045137 107 0.058
embryonic skeletal system development GO:0048706 3 0.057
response to wounding GO:0009611 254 0.056
Rat
response to oxygen levels GO:0070482 265 0.056
response to organophosphorus GO:0046683 102 0.053
developmental process involved in reproduction GO:0003006 159 0.053
Rat
cellular response to lipid GO:0071396 201 0.052
protein phosphorylation GO:0006468 345 0.052
response to hyperoxia GO:0055093 45 0.051
growth GO:0040007 165 0.051
response to cytokine GO:0034097 215 0.050
wound healing GO:0042060 122 0.050
Rat
brain development GO:0007420 247 0.049
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 5 0.047
response to radiation GO:0009314 137 0.046
cellular ion homeostasis GO:0006873 184 0.045
response to estradiol GO:0032355 164 0.045
response to nicotine GO:0035094 51 0.045
response to metal ion GO:0010038 253 0.045
cellular cation homeostasis GO:0030003 180 0.044
regulation of nervous system development GO:0051960 264 0.044
endochondral ossification GO:0001958 2 0.044
cellular response to tumor necrosis factor GO:0071356 46 0.044
response to decreased oxygen levels GO:0036293 237 0.044
bone development GO:0060348 25 0.044
response to x ray GO:0010165 15 0.043
protein complex assembly GO:0006461 263 0.042
cellular response to mechanical stimulus GO:0071260 48 0.042
response to monoamine GO:0071867 17 0.041
response to vitamin GO:0033273 131 0.041
cellular component movement GO:0006928 248 0.041
response to oxidative stress GO:0006979 186 0.040
cellular response to abiotic stimulus GO:0071214 85 0.040
protein heterotrimerization GO:0070208 2 0.040
collagen fibril organization GO:0030199 1 0.039
Zebrafish
regulation of multicellular organismal development GO:2000026 376 0.039
oxoacid metabolic process GO:0043436 290 0.039
response to acid chemical GO:0001101 222 0.038
rho protein signal transduction GO:0007266 11 0.037
striated muscle tissue development GO:0014706 58 0.037
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
Mouse
chemical homeostasis GO:0048878 292 0.036
cellular response to epidermal growth factor stimulus GO:0071364 12 0.035
organic acid metabolic process GO:0006082 292 0.035
cation homeostasis GO:0055080 195 0.035
peptidyl amino acid modification GO:0018193 126 0.035
cellular response to extracellular stimulus GO:0031668 73 0.034
negative regulation of cell development GO:0010721 82 0.034
non canonical wnt signaling pathway GO:0035567 3 0.034
response to increased oxygen levels GO:0036296 45 0.033
ion homeostasis GO:0050801 212 0.033
action potential GO:0001508 54 0.033
cellular metal ion homeostasis GO:0006875 172 0.032
response to fibroblast growth factor GO:0071774 29 0.032
response to ethanol GO:0045471 162 0.031
reproduction GO:0000003 245 0.031
response to thyroid hormone GO:0097066 17 0.031
positive regulation of response to stimulus GO:0048584 285 0.031
positive regulation of cellular component organization GO:0051130 200 0.031
g protein coupled receptor signaling pathway GO:0007186 242 0.031
cellular homeostasis GO:0019725 252 0.031
cellular response to cytokine stimulus GO:0071345 127 0.029
cellular response to acid chemical GO:0071229 75 0.029
response to glucose GO:0009749 136 0.029
muscle structure development GO:0061061 87 0.029
Rat
response to hypoxia GO:0001666 231 0.028
macromolecule localization GO:0033036 252 0.028
regulation of cell differentiation GO:0045595 320 0.027
cellular chemical homeostasis GO:0055082 247 0.026
response to zinc ion GO:0010043 39 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
Mouse
negative regulation of odontogenesis GO:0042483 1 0.026
cytolysis GO:0019835 4 0.026
regulation of transcription dna templated GO:0006355 374 0.026
Mouse
cellular response to stress GO:0033554 269 0.026
response to alkaloid GO:0043279 132 0.026
cellular response to thyroid hormone stimulus GO:0097067 5 0.025
regulation of signal transduction GO:0009966 318 0.025
reproductive process GO:0022414 372 0.025
Rat
positive regulation of gene expression GO:0010628 244 0.025
Mouse
small gtpase mediated signal transduction GO:0007264 36 0.024
reproductive system development GO:0061458 128 0.024
Rat
cellular response to nutrient GO:0031670 30 0.024
rna biosynthetic process GO:0032774 380 0.024
Mouse
regulation of hormone levels GO:0010817 187 0.024
vesicle mediated transport GO:0016192 181 0.023
cellular response to vitamin GO:0071295 21 0.023
immune system process GO:0002376 204 0.023
apoptotic process GO:0006915 381 0.023
metal ion homeostasis GO:0055065 186 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.022
muscle organ morphogenesis GO:0048644 1 0.022
gonad development GO:0008406 104 0.022
cellular response to nutrient levels GO:0031669 60 0.022
blood vessel development GO:0001568 69 0.022
head development GO:0060322 247 0.022
response to hydrogen peroxide GO:0042542 89 0.022
positive regulation of cell differentiation GO:0045597 217 0.021
cell motility GO:0048870 202 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
positive regulation of locomotion GO:0040017 102 0.021
chondrocyte differentiation GO:0002062 10 0.020
acrosome assembly GO:0001675 3 0.020
tissue regeneration GO:0042246 36 0.020
neuron projection development GO:0031175 273 0.020
transcription dna templated GO:0006351 377 0.020
Mouse
cell projection organization GO:0030030 302 0.019
regulation of neurogenesis GO:0050767 247 0.019
skeletal muscle tissue development GO:0007519 31 0.019
Rat
regulation of cell development GO:0060284 263 0.018
homeostatic process GO:0042592 331 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
female pregnancy GO:0007565 122 0.018
central nervous system development GO:0007417 311 0.018
positive regulation of non canonical wnt signaling pathway GO:2000052 1 0.018
negative regulation of signaling GO:0023057 157 0.018
peptidyl serine modification GO:0018209 34 0.018
single organism biosynthetic process GO:0044711 342 0.018
myeloid leukocyte activation GO:0002274 36 0.018
positive regulation of developmental process GO:0051094 283 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
biological adhesion GO:0022610 110 0.017
ras protein signal transduction GO:0007265 29 0.017
endoplasmic reticulum to cytosol transport GO:1903513 4 0.017
axis elongation GO:0003401 2 0.017
protein oligomerization GO:0051259 191 0.017
proteoglycan metabolic process GO:0006029 3 0.017
skeletal muscle organ development GO:0060538 33 0.016
Rat
rna metabolic process GO:0016070 406 0.016
Mouse
neuron differentiation GO:0030182 368 0.016
eye morphogenesis GO:0048592 4 0.016
Zebrafish
formation of primary germ layer GO:0001704 1 0.016
positive regulation of protein modification process GO:0031401 142 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.015
positive regulation of cellular component biogenesis GO:0044089 55 0.015
elastic fiber assembly GO:0048251 1 0.015
response to retinoic acid GO:0032526 63 0.015
regulation of odontogenesis GO:0042481 4 0.015
multicellular organism reproduction GO:0032504 233 0.015
response to reactive oxygen species GO:0000302 120 0.015
digestive tract development GO:0048565 39 0.015
erbb signaling pathway GO:0038127 23 0.014
regeneration GO:0031099 163 0.014
neuron development GO:0048666 286 0.014
response to amino acid GO:0043200 75 0.014
positive regulation of immune response GO:0050778 42 0.014
regulation of cell proliferation GO:0042127 359 0.014
cellular amine metabolic process GO:0044106 38 0.014
regulation of protein metabolic process GO:0051246 289 0.014
response to carbohydrate GO:0009743 183 0.014
regulation of molecular function GO:0065009 398 0.014
visual perception GO:0007601 3 0.013
response to hexose GO:0009746 144 0.013
rhythmic process GO:0048511 156 0.013
cellular hormone metabolic process GO:0034754 49 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
lipid biosynthetic process GO:0008610 128 0.013
bone morphogenesis GO:0060349 11 0.013
cell adhesion GO:0007155 110 0.013
cellular response to retinoic acid GO:0071300 27 0.013
regulation of rna metabolic process GO:0051252 391 0.013
Mouse
cellular component morphogenesis GO:0032989 155 0.013
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.013
eye development GO:0001654 50 0.013
Zebrafish
locomotion GO:0040011 237 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
Mouse
response to monosaccharide GO:0034284 159 0.013
skin development GO:0043588 17 0.013
immune response GO:0006955 104 0.013
circadian rhythm GO:0007623 88 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
Mouse
blood vessel morphogenesis GO:0048514 58 0.013
multicellular organismal signaling GO:0035637 44 0.013
organic substance catabolic process GO:1901575 316 0.012
artery development GO:0060840 3 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
hormone metabolic process GO:0042445 69 0.012
regulation of growth GO:0040008 105 0.012
regulation of apoptotic process GO:0042981 335 0.012
negative regulation of developmental process GO:0051093 125 0.012
regulation of immune response GO:0050776 55 0.012
catabolic process GO:0009056 351 0.012
sex differentiation GO:0007548 113 0.012
establishment of planar polarity GO:0001736 1 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
protein localization to organelle GO:0033365 57 0.012
response to indole 3 methanol GO:0071680 2 0.012
epithelium development GO:0060429 96 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
Mouse
organ regeneration GO:0031100 101 0.011
nucleic acid templated transcription GO:0097659 379 0.011
Mouse
regulation of cellular component organization GO:0051128 368 0.011
development of primary female sexual characteristics GO:0046545 56 0.011
replacement ossification GO:0036075 2 0.011
negative regulation of cell communication GO:0010648 158 0.011
regulation of response to stress GO:0080134 126 0.011
neurological system process GO:0050877 219 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
cellular macromolecule localization GO:0070727 122 0.010
positive regulation of multicellular organismal process GO:0051240 387 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
Mouse
regulation of cellular localization GO:0060341 263 0.010
neuronal action potential GO:0019228 35 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010
Mouse
cellular sodium ion homeostasis GO:0006883 4 0.010

Lum disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
collagen disease DOID:854 0 0.132
ehlers danlos syndrome DOID:13359 0 0.132
disease of anatomical entity DOID:7 0 0.132
musculoskeletal system disease DOID:17 0 0.132
connective tissue disease DOID:65 0 0.132
osteochondrodysplasia DOID:2256 0 0.061
bone development disease DOID:0080006 0 0.061
bone disease DOID:0080001 0 0.061
osteogenesis imperfecta DOID:12347 0 0.024
nervous system disease DOID:863 0 0.012