Rattus norvegicus

0 known processes

C4bpa

complement component 4 binding protein, alpha

(Aliases: MGC108761,C4BP)

C4bpa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to inorganic substance GO:0010035 377 0.375
response to extracellular stimulus GO:0009991 380 0.309
response to peptide hormone GO:0043434 278 0.250
Rat
response to metal ion GO:0010038 253 0.236
regulation of molecular function GO:0065009 398 0.223
Rat
defense response GO:0006952 194 0.220
Human Rat
regulation of phosphorylation GO:0042325 248 0.208
intracellular signal transduction GO:0035556 314 0.189
positive regulation of heterotypic cell cell adhesion GO:0034116 1 0.187
apoptotic process GO:0006915 381 0.186
reproductive process GO:0022414 372 0.178
Rat
response to bacterium GO:0009617 200 0.171
protein maturation GO:0051604 68 0.171
Human Rat
regulation of endothelial cell apoptotic process GO:2000351 3 0.167
regulation of protein metabolic process GO:0051246 289 0.165
Human Rat
positive regulation of response to stimulus GO:0048584 285 0.162
Human Rat
gland development GO:0048732 155 0.154
response to glucocorticoid GO:0051384 223 0.150
negative regulation of metabolic process GO:0009892 331 0.144
Human Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.138
Human Rat
response to nutrient levels GO:0031667 370 0.131
regulation of signal transduction GO:0009966 318 0.127
inflammatory response GO:0006954 150 0.112
Human Rat
response to corticosteroid GO:0031960 235 0.109
regulation of catalytic activity GO:0050790 304 0.104
Rat
programmed cell death GO:0012501 392 0.100
negative regulation of gene expression GO:0010629 199 0.098
Human Rat
multicellular organism reproduction GO:0032504 233 0.098
Rat
regulation of phosphate metabolic process GO:0019220 349 0.094
immune response GO:0006955 104 0.093
Human Rat
response to hexose GO:0009746 144 0.092
multi organism reproductive process GO:0044703 262 0.092
Rat
response to lipopolysaccharide GO:0032496 191 0.091
macromolecule localization GO:0033036 252 0.085
Rat
regulation of protein maturation GO:1903317 50 0.083
Human Rat
signal transduction by phosphorylation GO:0023014 144 0.083
response to external biotic stimulus GO:0043207 221 0.081
regulation of apoptotic process GO:0042981 335 0.080
protein complex assembly GO:0006461 263 0.077
proteolysis GO:0006508 175 0.076
Rat
macromolecular complex assembly GO:0065003 273 0.076
negative regulation of response to stimulus GO:0048585 155 0.073
Human Rat
cellular response to hormone stimulus GO:0032870 247 0.073
regulation of phosphorus metabolic process GO:0051174 349 0.070
mapk cascade GO:0000165 140 0.070
negative regulation of cell death GO:0060548 229 0.070
negative regulation of protein metabolic process GO:0051248 114 0.070
Human Rat
regulation of hydrolase activity GO:0051336 143 0.069
oxoacid metabolic process GO:0043436 290 0.067
protein localization GO:0008104 191 0.067
heterotypic cell cell adhesion GO:0034113 2 0.067
wound healing GO:0042060 122 0.066
Rat
negative regulation of epithelial cell proliferation GO:0050680 16 0.065
response to peptide GO:1901652 292 0.065
Rat
response to other organism GO:0051707 220 0.064
regulation of mapk cascade GO:0043408 116 0.064
biological adhesion GO:0022610 110 0.063
complement activation GO:0006956 11 0.061
Human Rat
regulation of intracellular signal transduction GO:1902531 218 0.060
negative regulation of molecular function GO:0044092 133 0.058
Rat
cellular response to organonitrogen compound GO:0071417 197 0.058
response to biotic stimulus GO:0009607 226 0.058
regulation of cellular protein metabolic process GO:0032268 267 0.057
response to radiation GO:0009314 137 0.057
single organism reproductive process GO:0044702 297 0.055
Rat
protein oligomerization GO:0051259 191 0.053
coagulation GO:0050817 28 0.053
Rat
positive regulation of biosynthetic process GO:0009891 319 0.053
cell adhesion GO:0007155 110 0.052
cellular component assembly GO:0022607 360 0.052
response to monosaccharide GO:0034284 159 0.051
negative regulation of programmed cell death GO:0043069 183 0.051
cellular chemical homeostasis GO:0055082 247 0.050
cellular response to oxygen containing compound GO:1901701 386 0.050
blood circulation GO:0008015 183 0.049
positive regulation of phosphorus metabolic process GO:0010562 262 0.048
negative regulation of signal transduction GO:0009968 83 0.048
reproduction GO:0000003 245 0.047
Rat
immune system process GO:0002376 204 0.047
Human Rat
nitrogen compound transport GO:0071705 229 0.046
positive regulation of signal transduction GO:0009967 175 0.046
cellular response to stress GO:0033554 269 0.046
regulation of proteolysis GO:0030162 66 0.046
positive regulation of cellular biosynthetic process GO:0031328 295 0.045
response to nutrient GO:0007584 248 0.045
regulation of programmed cell death GO:0043067 341 0.045
reactive oxygen species metabolic process GO:0072593 37 0.045
protein processing GO:0016485 68 0.044
Human Rat
regulation of anatomical structure morphogenesis GO:0022603 141 0.043
response to glucose GO:0009749 136 0.043
endothelial cell apoptotic process GO:0072577 3 0.043
positive regulation of phosphorylation GO:0042327 177 0.043
response to decreased oxygen levels GO:0036293 237 0.042
macromolecular complex subunit organization GO:0043933 339 0.042
response to carbohydrate GO:0009743 183 0.041
regulation of secretion by cell GO:1903530 208 0.041
cellular response to nitrogen compound GO:1901699 210 0.041
negative regulation of cellular metabolic process GO:0031324 281 0.040
response to oxygen levels GO:0070482 265 0.040
negative regulation of apoptotic process GO:0043066 181 0.040
cellular response to lipid GO:0071396 201 0.039
locomotion GO:0040011 237 0.039
protein transport GO:0015031 132 0.038
regeneration GO:0031099 163 0.037
Rat
negative regulation of protein maturation GO:1903318 47 0.037
Human Rat
response to hypoxia GO:0001666 231 0.037
positive regulation of phosphate metabolic process GO:0045937 262 0.037
spermatogenesis GO:0007283 99 0.037
Rat
response to ionizing radiation GO:0010212 59 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
protein complex subunit organization GO:0071822 302 0.035
organ regeneration GO:0031100 101 0.035
Rat
negative regulation of cell communication GO:0010648 158 0.035
cellular response to peptide hormone stimulus GO:0071375 120 0.035
single organism cellular localization GO:1902580 102 0.035
cellular ketone metabolic process GO:0042180 51 0.034
reactive nitrogen species metabolic process GO:2001057 1 0.034
regulation of cell adhesion GO:0030155 52 0.034
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.034
carbohydrate metabolic process GO:0005975 130 0.033
catabolic process GO:0009056 351 0.033
Human
cellular response to endogenous stimulus GO:0071495 377 0.033
regulation of cellular localization GO:0060341 263 0.033
regulation of multicellular organismal development GO:2000026 376 0.033
negative regulation of cellular protein metabolic process GO:0032269 106 0.033
cellular response to oxidative stress GO:0034599 76 0.033
blood coagulation GO:0007596 26 0.033
Rat
negative regulation of proteolysis GO:0045861 41 0.032
hormone metabolic process GO:0042445 69 0.032
regulation of hormone levels GO:0010817 187 0.032
response to wounding GO:0009611 254 0.032
Human Rat
innate immune response GO:0045087 35 0.032
urea cycle GO:0000050 5 0.031
regulation of protein modification process GO:0031399 194 0.030
organic acid metabolic process GO:0006082 292 0.030
tissue development GO:0009888 252 0.030
response to ketone GO:1901654 182 0.030
response to purine containing compound GO:0014074 126 0.030
regulation of immune system process GO:0002682 123 0.030
Human Rat
response to acid chemical GO:0001101 222 0.029
protein homotrimerization GO:0070207 15 0.029
regulation of system process GO:0044057 208 0.029
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.029
response to platinum ion GO:0070541 4 0.029
glycerolipid metabolic process GO:0046486 67 0.029
positive regulation of intracellular signal transduction GO:1902533 138 0.029
negative regulation of endopeptidase activity GO:0010951 36 0.029
regulation of protein processing GO:0070613 50 0.028
Human Rat
cation homeostasis GO:0055080 195 0.028
response to estradiol GO:0032355 164 0.028
response to molecule of bacterial origin GO:0002237 194 0.028
positive regulation of catalytic activity GO:0043085 184 0.028
regulation of response to stress GO:0080134 126 0.028
Human Rat
protein complex biogenesis GO:0070271 263 0.028
regulation of reactive oxygen species metabolic process GO:2000377 26 0.028
negative regulation of developmental process GO:0051093 125 0.028
cellular response to insulin stimulus GO:0032869 81 0.028
protein phosphorylation GO:0006468 345 0.028
hepaticobiliary system development GO:0061008 90 0.028
cellular response to reactive oxygen species GO:0034614 55 0.027
response to vitamin GO:0033273 131 0.027
response to growth factor GO:0070848 189 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
negative regulation of catalytic activity GO:0043086 103 0.026
Rat
cellular response to steroid hormone stimulus GO:0071383 93 0.026
regulation of cellular response to stress GO:0080135 49 0.026
regulation of immunoglobulin mediated immune response GO:0002889 2 0.026
Human
regulation of cellular component organization GO:0051128 368 0.026
regulation of rna biosynthetic process GO:2001141 381 0.025
hepatocyte proliferation GO:0072574 3 0.025
acylglycerol metabolic process GO:0006639 21 0.025
b cell mediated immunity GO:0019724 4 0.025
Human
response to transition metal nanoparticle GO:1990267 122 0.025
humoral immune response GO:0006959 12 0.025
Human Rat
positive regulation of fibroblast proliferation GO:0048146 15 0.025
positive regulation of secretion by cell GO:1903532 128 0.025
response to dexamethasone GO:0071548 49 0.024
regulation of heterotypic cell cell adhesion GO:0034114 2 0.024
response to calcium ion GO:0051592 59 0.024
hormone secretion GO:0046879 115 0.024
gamete generation GO:0007276 124 0.024
Rat
cellular response to cytokine stimulus GO:0071345 127 0.024
peptidyl amino acid modification GO:0018193 126 0.024
response to activity GO:0014823 73 0.024
cellular homeostasis GO:0019725 252 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
response to camp GO:0051591 91 0.024
response to mechanical stimulus GO:0009612 134 0.023
female pregnancy GO:0007565 122 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
negative regulation of protein processing GO:0010955 47 0.023
Human Rat
circulatory system development GO:0072359 134 0.023
cellular component biogenesis GO:0044085 368 0.023
cellular response to interferon gamma GO:0071346 14 0.023
cellular response to corticosteroid stimulus GO:0071384 69 0.022
liver development GO:0001889 90 0.022
positive regulation of blood coagulation GO:0030194 4 0.022
single organism cell adhesion GO:0098602 46 0.022
negative regulation of phosphorus metabolic process GO:0010563 80 0.022
single organism intracellular transport GO:1902582 166 0.022
growth GO:0040007 165 0.022
cellular amine metabolic process GO:0044106 38 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
cellular amide metabolic process GO:0043603 44 0.022
cellular component movement GO:0006928 248 0.021
organic substance catabolic process GO:1901575 316 0.021
Human
vesicle mediated transport GO:0016192 181 0.021
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.021
positive regulation of immunoglobulin production GO:0002639 4 0.021
protein homooligomerization GO:0051260 91 0.021
carboxylic acid metabolic process GO:0019752 289 0.021
extracellular matrix constituent secretion GO:0070278 4 0.021
positive regulation of signaling GO:0023056 270 0.021
regulation of peptidase activity GO:0052547 55 0.021
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.021
rhythmic process GO:0048511 156 0.021
response to reactive oxygen species GO:0000302 120 0.020
response to oxidative stress GO:0006979 186 0.020
regulation of cell development GO:0060284 263 0.020
intracellular transport GO:0046907 185 0.020
positive regulation of cell communication GO:0010647 271 0.020
secretion by cell GO:0032940 248 0.020
organ morphogenesis GO:0009887 75 0.020
positive regulation of mapk cascade GO:0043410 92 0.020
response to cytokine GO:0034097 215 0.020
developmental growth GO:0048589 100 0.020
rna metabolic process GO:0016070 406 0.020
organic hydroxy compound metabolic process GO:1901615 115 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
Human
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.019
positive regulation of nitric oxide biosynthetic process GO:0045429 14 0.019
cellular protein complex assembly GO:0043623 44 0.019
aging GO:0007568 241 0.019
regulation of vesicle mediated transport GO:0060627 81 0.019
immune effector process GO:0002252 53 0.019
Human Rat
homeostatic process GO:0042592 331 0.019
reactive oxygen species biosynthetic process GO:1903409 8 0.018
nucleic acid templated transcription GO:0097659 379 0.018
regulation of cell proliferation GO:0042127 359 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
secretion GO:0046903 307 0.018
cellular response to external stimulus GO:0071496 118 0.018
neuron projection development GO:0031175 273 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
establishment of protein localization GO:0045184 141 0.018
immunoglobulin mediated immune response GO:0016064 4 0.017
Human
cellular response to organic cyclic compound GO:0071407 202 0.017
transmission of nerve impulse GO:0019226 42 0.017
cellular response to glucocorticoid stimulus GO:0071385 68 0.017
cellular sodium ion homeostasis GO:0006883 4 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
regulation of plasminogen activation GO:0010755 2 0.017
circadian rhythm GO:0007623 88 0.017
negative regulation of cell development GO:0010721 82 0.017
response to fatty acid GO:0070542 65 0.016
regulation of transcription dna templated GO:0006355 374 0.016
amide transport GO:0042886 105 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
regulation of serine type peptidase activity GO:1902571 1 0.016
alkaloid metabolic process GO:0009820 3 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.016
positive regulation of catabolic process GO:0009896 78 0.016
Human
extrinsic apoptotic signaling pathway GO:0097191 10 0.016
regulation of angiogenesis GO:0045765 39 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
regulation of rna metabolic process GO:0051252 391 0.016
cell type specific apoptotic process GO:0097285 134 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
positive regulation of triglyceride biosynthetic process GO:0010867 4 0.016
steroid metabolic process GO:0008202 73 0.016
exocytosis GO:0006887 60 0.016
developmental process involved in reproduction GO:0003006 159 0.016
regulation of neurogenesis GO:0050767 247 0.016
regulation of epithelial cell proliferation GO:0050678 49 0.016
peptide transport GO:0015833 97 0.016
epithelium development GO:0060429 96 0.015
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.015
chemical homeostasis GO:0048878 292 0.015
negative regulation of peptidase activity GO:0010466 38 0.015
regulation of secretion GO:0051046 224 0.015
regulation of exocytosis GO:0017157 37 0.015
response to insulin GO:0032868 133 0.015
fibrinolysis GO:0042730 2 0.015
response to organophosphorus GO:0046683 102 0.015
negative regulation of biomineral tissue development GO:0070168 2 0.015
epithelial cell differentiation GO:0030855 71 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
amine metabolic process GO:0009308 38 0.015
macromolecule catabolic process GO:0009057 58 0.015
Human
vasculature development GO:0001944 70 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
neutral lipid metabolic process GO:0006638 21 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
regulation of hormone secretion GO:0046883 106 0.015
cellular response to hydroperoxide GO:0071447 2 0.015
cellular response to alkaloid GO:0071312 25 0.014
regulation of cell differentiation GO:0045595 320 0.014
cellular ion homeostasis GO:0006873 184 0.014
eye morphogenesis GO:0048592 4 0.014
negative regulation of neurogenesis GO:0050768 78 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
Rat
regulation of neuron projection development GO:0010975 161 0.014
protein polymerization GO:0051258 22 0.014
positive regulation of cell adhesion GO:0045785 30 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
regulation of protein transport GO:0051223 68 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
lipid metabolic process GO:0006629 283 0.014
cell matrix adhesion GO:0007160 19 0.014
positive regulation of developmental process GO:0051094 283 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
cellular response to hexose stimulus GO:0071331 65 0.014
dendrite development GO:0016358 72 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
rna biosynthetic process GO:0032774 380 0.013
single organism biosynthetic process GO:0044711 342 0.013
multicellular organismal signaling GO:0035637 44 0.013
gonad development GO:0008406 104 0.013
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.013
negative regulation of signaling GO:0023057 157 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
response to retinoic acid GO:0032526 63 0.013
positive regulation of blood circulation GO:1903524 65 0.013
leukocyte mediated immunity GO:0002443 28 0.013
Human
regulation of cell cell adhesion GO:0022407 14 0.013
positive regulation of molecular function GO:0044093 230 0.013
heart morphogenesis GO:0003007 3 0.013
behavior GO:0007610 205 0.013
defense response to gram negative bacterium GO:0050829 3 0.013
stress activated mapk cascade GO:0051403 35 0.013
single organism catabolic process GO:0044712 283 0.013
cardiovascular system development GO:0072358 134 0.013
nucleocytoplasmic transport GO:0006913 48 0.013
peptide metabolic process GO:0006518 32 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
carbohydrate homeostasis GO:0033500 75 0.013
cellular macromolecule localization GO:0070727 122 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
renin angiotensin regulation of aldosterone production GO:0002018 3 0.013
regulation of nitric oxide biosynthetic process GO:0045428 20 0.013
defense response to gram positive bacterium GO:0050830 2 0.013
regulation of erk1 and erk2 cascade GO:0070372 41 0.013
lipid localization GO:0010876 62 0.013
Rat
peptide secretion GO:0002790 86 0.013
male gamete generation GO:0048232 99 0.012
Rat
epithelial cell proliferation GO:0050673 54 0.012
positive regulation of secretion GO:0051047 140 0.012
cellular response to mechanical stimulus GO:0071260 48 0.012
platelet aggregation GO:0070527 4 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
stress activated protein kinase signaling cascade GO:0031098 37 0.012
single organismal cell cell adhesion GO:0016337 42 0.012
regulation of peptide secretion GO:0002791 82 0.012
response to estrogen GO:0043627 232 0.012
neurological system process GO:0050877 219 0.012
sulfur compound metabolic process GO:0006790 70 0.012
organelle organization GO:0006996 266 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
protein secretion GO:0009306 34 0.012
divalent metal ion transport GO:0070838 132 0.012
coenzyme metabolic process GO:0006732 86 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
positive regulation of oxidoreductase activity GO:0051353 7 0.012
transcription dna templated GO:0006351 377 0.012
peptide hormone secretion GO:0030072 84 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
neuron differentiation GO:0030182 368 0.012
cytoplasmic transport GO:0016482 115 0.012
cation transport GO:0006812 382 0.012
protein targeting GO:0006605 61 0.012
regulation of vasculature development GO:1901342 44 0.012
negative regulation of hydrolase activity GO:0051346 52 0.011
nuclear transport GO:0051169 49 0.011
cell projection organization GO:0030030 302 0.011
divalent inorganic cation transport GO:0072511 134 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
cell activation GO:0001775 97 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
positive regulation of immune response GO:0050778 42 0.011
Human Rat
response to amino acid GO:0043200 75 0.011
metal ion transport GO:0030001 289 0.011
regulation of endopeptidase activity GO:0052548 51 0.011
positive regulation of exocytosis GO:0045921 19 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
central nervous system development GO:0007417 311 0.011
response to triglyceride GO:0034014 3 0.011
cell communication involved in cardiac conduction GO:0086065 2 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
negative regulation of humoral immune response GO:0002921 4 0.011
Human Rat
cell cell signaling GO:0007267 335 0.011
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.011
hormone transport GO:0009914 121 0.011
calcium ion transport GO:0006816 131 0.011
circulatory system process GO:0003013 183 0.010
positive regulation of protein secretion GO:0050714 19 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
negative regulation of fibrinolysis GO:0051918 2 0.010
cardiac conduction GO:0061337 2 0.010
regulation of fibrinolysis GO:0051917 2 0.010
cellular response to carbohydrate stimulus GO:0071322 72 0.010
regulation of immune response GO:0050776 55 0.010
Human Rat
maintenance of location GO:0051235 17 0.010
regulation of neuron differentiation GO:0045664 208 0.010
cellular protein localization GO:0034613 122 0.010
negative regulation of cellular amide metabolic process GO:0034249 1 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010
cell motility GO:0048870 202 0.010

C4bpa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.389
disease of anatomical entity DOID:7 0 0.389
blood coagulation disease DOID:1247 0 0.389
inherited blood coagulation disease DOID:2214 0 0.389
hematopoietic system disease DOID:74 0 0.389
disease of metabolism DOID:0014667 0 0.093
inherited metabolic disorder DOID:655 0 0.026
vascular disease DOID:178 0 0.015
cardiovascular system disease DOID:1287 0 0.015
artery disease DOID:0050828 0 0.014
nervous system disease DOID:863 0 0.014
acquired metabolic disease DOID:0060158 0 0.013
musculoskeletal system disease DOID:17 0 0.013
sensory system disease DOID:0050155 0 0.012