Rattus norvegicus

139 known processes

Pten

phosphatase and tensin homolog

(Aliases: Mmac,TEP1,MMAC1)

Pten biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein phosphorylation GO:0006468 345 0.161
Human
regulation of protein metabolic process GO:0051246 289 0.138
Human
regulation of molecular function GO:0065009 398 0.127
Human
catabolic process GO:0009056 351 0.117
Human
negative regulation of cellular metabolic process GO:0031324 281 0.114
Human
programmed cell death GO:0012501 392 0.105
transcription dna templated GO:0006351 377 0.101
Human
rna metabolic process GO:0016070 406 0.099
Human
response to nutrient GO:0007584 248 0.093
regulation of apoptotic process GO:0042981 335 0.092
cellular catabolic process GO:0044248 295 0.080
Human
regulation of transcription dna templated GO:0006355 374 0.074
Human
regulation of cellular component organization GO:0051128 368 0.071
transmembrane transport GO:0055085 412 0.065
regulation of catalytic activity GO:0050790 304 0.064
Human
regulation of phosphorus metabolic process GO:0051174 349 0.063
Human
organic substance catabolic process GO:1901575 316 0.062
Human
regulation of rna biosynthetic process GO:2001141 381 0.062
Human
negative regulation of macromolecule metabolic process GO:0010605 260 0.060
Human
regulation of rna metabolic process GO:0051252 391 0.060
Human
positive regulation of transport GO:0051050 245 0.058
reproduction GO:0000003 245 0.057
regulation of cellular protein metabolic process GO:0032268 267 0.057
Human
nucleic acid templated transcription GO:0097659 379 0.056
Human
negative regulation of metabolic process GO:0009892 331 0.055
Human
reproductive process GO:0022414 372 0.055
response to biotic stimulus GO:0009607 226 0.054
response to estrogen GO:0043627 232 0.053
regulation of response to stress GO:0080134 126 0.050
multi organism reproductive process GO:0044703 262 0.048
regulation of signal transduction GO:0009966 318 0.048
Human
negative regulation of cell communication GO:0010648 158 0.048
regulation of phosphate metabolic process GO:0019220 349 0.046
Human
positive regulation of molecular function GO:0044093 230 0.045
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.045
protein catabolic process GO:0030163 30 0.045
Human
cellular response to endogenous stimulus GO:0071495 377 0.044
negative regulation of programmed cell death GO:0043069 183 0.044
cellular response to hormone stimulus GO:0032870 247 0.044
regulation of secretion by cell GO:1903530 208 0.043
intracellular signal transduction GO:0035556 314 0.042
Human
regulation of nucleic acid templated transcription GO:1903506 380 0.041
Human
proteolysis GO:0006508 175 0.041
Human
regulation of ion transport GO:0043269 245 0.041
positive regulation of biosynthetic process GO:0009891 319 0.040
cellular component biogenesis GO:0044085 368 0.039
Human
cellular ketone metabolic process GO:0042180 51 0.039
protein autophosphorylation GO:0046777 66 0.038
enzyme linked receptor protein signaling pathway GO:0007167 116 0.038
negative regulation of gene expression GO:0010629 199 0.037
multicellular organism reproduction GO:0032504 233 0.037
ion transmembrane transport GO:0034220 365 0.037
apoptotic process GO:0006915 381 0.037
tissue development GO:0009888 252 0.036
regulation of secretion GO:0051046 224 0.036
defense response GO:0006952 194 0.036
macromolecule localization GO:0033036 252 0.036
cellular component assembly GO:0022607 360 0.036
Human
cellular response to stress GO:0033554 269 0.036
single organism reproductive process GO:0044702 297 0.036
brain development GO:0007420 247 0.035
response to extracellular stimulus GO:0009991 380 0.034
macromolecular complex assembly GO:0065003 273 0.034
lipid metabolic process GO:0006629 283 0.034
response to external biotic stimulus GO:0043207 221 0.033
cellular response to peptide hormone stimulus GO:0071375 120 0.033
cellular response to oxygen containing compound GO:1901701 386 0.033
response to ethanol GO:0045471 162 0.033
behavior GO:0007610 205 0.033
transcription from rna polymerase ii promoter GO:0006366 252 0.032
central nervous system development GO:0007417 311 0.032
response to inorganic substance GO:0010035 377 0.032
bmp signaling pathway GO:0030509 4 0.032
secretion GO:0046903 307 0.032
regulation of cellular localization GO:0060341 263 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
negative regulation of molecular function GO:0044092 133 0.031
Human
regulation of kinase activity GO:0043549 117 0.030
Human
actin filament based process GO:0030029 86 0.030
carboxylic acid metabolic process GO:0019752 289 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.030
regulation of cellular catabolic process GO:0031329 101 0.030
Human
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
rna biosynthetic process GO:0032774 380 0.030
Human
negative regulation of apoptotic process GO:0043066 181 0.029
cation transport GO:0006812 382 0.029
positive regulation of cellular protein metabolic process GO:0032270 167 0.029
Human
multicellular organismal reproductive process GO:0048609 233 0.029
positive regulation of cellular component organization GO:0051130 200 0.029
Human
regulation of mapk cascade GO:0043408 116 0.029
oxoacid metabolic process GO:0043436 290 0.028
positive regulation of cell communication GO:0010647 271 0.028
positive regulation of cellular biosynthetic process GO:0031328 295 0.028
negative regulation of signaling GO:0023057 157 0.028
developmental process involved in reproduction GO:0003006 159 0.028
regulation of multicellular organismal development GO:2000026 376 0.028
nitrogen compound transport GO:0071705 229 0.028
regulation of cytokine production GO:0001817 56 0.028
signal transduction by phosphorylation GO:0023014 144 0.027
response to radiation GO:0009314 137 0.027
negative regulation of signal transduction GO:0009968 83 0.027
Human
organic acid metabolic process GO:0006082 292 0.027
anatomical structure morphogenesis GO:0009653 298 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
response to other organism GO:0051707 220 0.026
homeostatic process GO:0042592 331 0.026
regulation of cell proliferation GO:0042127 359 0.026
response to glucocorticoid GO:0051384 223 0.025
secretion by cell GO:0032940 248 0.025
neuron development GO:0048666 286 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
response to toxic substance GO:0009636 133 0.025
positive regulation of signaling GO:0023056 270 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
regulation of phosphorylation GO:0042325 248 0.024
Human
locomotion GO:0040011 237 0.024
Human
positive regulation of protein metabolic process GO:0051247 178 0.024
Human
regulation of protein localization GO:0032880 81 0.024
regulation of protein transport GO:0051223 68 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.023
response to cytokine GO:0034097 215 0.023
metal ion transport GO:0030001 289 0.023
response to growth factor GO:0070848 189 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
response to nutrient levels GO:0031667 370 0.023
muscle cell proliferation GO:0033002 84 0.023
response to peptide GO:1901652 292 0.023
cell motility GO:0048870 202 0.022
Human
negative regulation of biosynthetic process GO:0009890 168 0.022
cell cell signaling GO:0007267 335 0.022
cellular chemical homeostasis GO:0055082 247 0.022
nucleobase containing compound catabolic process GO:0034655 152 0.022
regulation of programmed cell death GO:0043067 341 0.022
ion homeostasis GO:0050801 212 0.021
head development GO:0060322 247 0.021
neurological system process GO:0050877 219 0.021
regulation of response to external stimulus GO:0032101 106 0.021
cellular homeostasis GO:0019725 252 0.021
cellular response to organonitrogen compound GO:0071417 197 0.021
dephosphorylation GO:0016311 98 0.021
cation transmembrane transport GO:0098655 263 0.021
response to wounding GO:0009611 254 0.021
response to bacterium GO:0009617 200 0.021
inorganic cation transmembrane transport GO:0098662 202 0.021
response to corticosteroid GO:0031960 235 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
regulation of endocytosis GO:0030100 42 0.020
wound healing GO:0042060 122 0.020
peptidyl amino acid modification GO:0018193 126 0.020
positive regulation of phosphate metabolic process GO:0045937 262 0.020
purine containing compound metabolic process GO:0072521 253 0.020
regulation of transferase activity GO:0051338 123 0.020
Human
neuron differentiation GO:0030182 368 0.020
heterocycle catabolic process GO:0046700 167 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
amine metabolic process GO:0009308 38 0.019
heart development GO:0007507 72 0.019
positive regulation of developmental process GO:0051094 283 0.019
anion transport GO:0006820 178 0.019
response to peptide hormone GO:0043434 278 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
immune system process GO:0002376 204 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
actin cytoskeleton organization GO:0030036 73 0.019
positive regulation of signal transduction GO:0009967 175 0.019
smooth muscle cell proliferation GO:0048659 77 0.019
positive regulation of cell death GO:0010942 184 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
negative regulation of rna metabolic process GO:0051253 123 0.019
regulation of protein modification process GO:0031399 194 0.019
Human
response to light stimulus GO:0009416 52 0.019
regulation of hormone levels GO:0010817 187 0.019
response to alkaloid GO:0043279 132 0.018
positive regulation of gene expression GO:0010628 244 0.018
nucleotide metabolic process GO:0009117 279 0.018
intracellular transport GO:0046907 185 0.018
multi multicellular organism process GO:0044706 138 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
regulation of body fluid levels GO:0050878 90 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
Human
regulation of cell cycle GO:0051726 73 0.018
Human
sexual reproduction GO:0019953 148 0.018
metal ion homeostasis GO:0055065 186 0.018
chemical homeostasis GO:0048878 292 0.018
hormone transport GO:0009914 121 0.018
aging GO:0007568 241 0.018
regulation of catabolic process GO:0009894 113 0.018
Human
immune response GO:0006955 104 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.018
response to vitamin GO:0033273 131 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.017
sex differentiation GO:0007548 113 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
regulation of nervous system development GO:0051960 264 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
Human
positive regulation of apoptotic process GO:0043065 154 0.017
carboxylic acid transport GO:0046942 115 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
regulation of cell differentiation GO:0045595 320 0.017
regulation of nucleotide metabolic process GO:0006140 117 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
circulatory system process GO:0003013 183 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
circulatory system development GO:0072359 134 0.017
blood circulation GO:0008015 183 0.017
vesicle mediated transport GO:0016192 181 0.017
cellular ion homeostasis GO:0006873 184 0.017
muscle structure development GO:0061061 87 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
cellular macromolecule localization GO:0070727 122 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
growth GO:0040007 165 0.016
protein complex assembly GO:0006461 263 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
Human
developmental growth GO:0048589 100 0.016
gland development GO:0048732 155 0.016
cell growth GO:0016049 104 0.016
negative regulation of catalytic activity GO:0043086 103 0.016
Human
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
Human
negative regulation of transport GO:0051051 136 0.016
macromolecule catabolic process GO:0009057 58 0.016
Human
positive regulation of transferase activity GO:0051347 81 0.016
Human
glycerolipid metabolic process GO:0046486 67 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
organelle organization GO:0006996 266 0.015
Human
cellular cation homeostasis GO:0030003 180 0.015
mapk cascade GO:0000165 140 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
hepaticobiliary system development GO:0061008 90 0.015
protein oligomerization GO:0051259 191 0.015
organophosphate metabolic process GO:0019637 370 0.015
positive regulation of nucleotide catabolic process GO:0030813 53 0.015
response to ketone GO:1901654 182 0.015
aromatic compound catabolic process GO:0019439 168 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
regulation of metal ion transport GO:0010959 118 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
cation homeostasis GO:0055080 195 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
single organism biosynthetic process GO:0044711 342 0.015
regulation of hydrolase activity GO:0051336 143 0.014
cellular amine metabolic process GO:0044106 38 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
cellular response to lipid GO:0071396 201 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.014
protein modification by small protein conjugation or removal GO:0070647 35 0.014
Human
cytoplasmic transport GO:0016482 115 0.014
response to oxygen levels GO:0070482 265 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cellular response to peptide GO:1901653 133 0.014
positive regulation of secretion GO:0051047 140 0.014
gamete generation GO:0007276 124 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
Human
purine nucleotide catabolic process GO:0006195 136 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
Human
ras protein signal transduction GO:0007265 29 0.014
cell projection organization GO:0030030 302 0.014
protein complex subunit organization GO:0071822 302 0.014
response to acid chemical GO:0001101 222 0.014
response to estradiol GO:0032355 164 0.013
regulation of cell growth GO:0001558 85 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
development of primary sexual characteristics GO:0045137 107 0.013
regulation of nucleotide catabolic process GO:0030811 65 0.013
nucleoside metabolic process GO:0009116 179 0.013
positive regulation of catabolic process GO:0009896 78 0.013
Human
regulation of amine transport GO:0051952 54 0.013
protein transport GO:0015031 132 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
response to carbohydrate GO:0009743 183 0.013
muscle system process GO:0003012 115 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
cytokine production GO:0001816 61 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
amide transport GO:0042886 105 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
cellular component movement GO:0006928 248 0.013
Human
membrane organization GO:0061024 94 0.013
protein localization GO:0008104 191 0.013
response to hypoxia GO:0001666 231 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
response to mechanical stimulus GO:0009612 134 0.013
response to metal ion GO:0010038 253 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
response to decreased oxygen levels GO:0036293 237 0.013
syncytium formation by plasma membrane fusion GO:0000768 3 0.012
organic anion transport GO:0015711 132 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
Human
regulation of ion transmembrane transport GO:0034765 121 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
neuron projection morphogenesis GO:0048812 122 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
organic acid transport GO:0015849 116 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of cell development GO:0060284 263 0.012
protein modification by small protein conjugation GO:0032446 31 0.012
Human
nucleoside triphosphate catabolic process GO:0009143 123 0.012
stress activated mapk cascade GO:0051403 35 0.012
hormone secretion GO:0046879 115 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
regulation of purine nucleotide catabolic process GO:0033121 65 0.012
regulation of anion transport GO:0044070 43 0.012
calcium ion homeostasis GO:0055074 162 0.012
neuron projection development GO:0031175 273 0.012
regulation of hormone secretion GO:0046883 106 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
male gamete generation GO:0048232 99 0.012
response to ammonium ion GO:0060359 71 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.012
regulation of transmembrane transport GO:0034762 122 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
inflammatory response GO:0006954 150 0.012
asymmetric protein localization GO:0008105 2 0.012
rho protein signal transduction GO:0007266 11 0.012
negative regulation of organ growth GO:0046621 3 0.012
regulation of neurogenesis GO:0050767 247 0.012
lipid transport GO:0006869 61 0.012
regulation of neuron projection development GO:0010975 161 0.012
carbohydrate metabolic process GO:0005975 130 0.012
Human
localization of cell GO:0051674 202 0.012
Human
regulation of establishment of protein localization GO:0070201 69 0.011
negative regulation of cell death GO:0060548 229 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
Human
female pregnancy GO:0007565 122 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
regeneration GO:0031099 163 0.011
regulation of cellular response to stress GO:0080135 49 0.011
signal release GO:0023061 145 0.011
protein ubiquitination GO:0016567 28 0.011
Human
regulation of nucleoside metabolic process GO:0009118 66 0.011
negative regulation of intracellular signal transduction GO:1902532 38 0.011
Human
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
negative regulation of developmental process GO:0051093 125 0.011
response to glucose GO:0009749 136 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
b cell differentiation GO:0030183 2 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
purine containing compound catabolic process GO:0072523 138 0.011
cytoskeleton organization GO:0007010 111 0.011
single organism intracellular transport GO:1902582 166 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
peptide hormone secretion GO:0030072 84 0.011
multicellular organism growth GO:0035264 1 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
Human
cell morphogenesis involved in differentiation GO:0000904 119 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
biological adhesion GO:0022610 110 0.011
Human
positive regulation of growth GO:0045927 55 0.011
cofactor metabolic process GO:0051186 95 0.011
liver development GO:0001889 90 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
reproductive system development GO:0061458 128 0.011
peptide secretion GO:0002790 86 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
locomotor rhythm GO:0045475 1 0.011
cardiovascular system development GO:0072358 134 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
negative regulation of secretion by cell GO:1903531 72 0.010
spermatogenesis GO:0007283 99 0.010
regulation of system process GO:0044057 208 0.010
response to oxidative stress GO:0006979 186 0.010
positive regulation of cell development GO:0010720 176 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
regulation of ion transmembrane transporter activity GO:0032412 48 0.010
regulation of mrna splicing via spliceosome GO:0048024 3 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
nuclear transport GO:0051169 49 0.010
regulation of actin cytoskeleton organization GO:0032956 30 0.010
cellular macromolecule catabolic process GO:0044265 29 0.010
Human
regulation of cellular component movement GO:0051270 150 0.010
Human
negative regulation of secretion GO:0051048 82 0.010
jnk cascade GO:0007254 28 0.010
regulation of cytoskeleton organization GO:0051493 49 0.010

Pten disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org